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https://www.readbyqxmd.com/read/29407244/who-is-more-flexible-awareness-of-changing-context-but-not-working-memory-capacity-modulates-inhibitory-control
#1
Shan-Chuan Teng, Hsuan-Fu Chao, Yunn-Wen Lien
The present study examines how a person's working memory capacity (WMC) and awareness of change in context influences modulating inhibitory control. Context was manipulated by changing the predictive validity of a prime to a following target (i.e., the proportion of prime repetition) across three phases in a single-prime negative priming task. The prime was a distractor for the following target when the proportion was 25% (in the first and third phases) and a useful cue when the proportion rose to 75% (in the second phase)...
February 1, 2018: Acta Psychologica
https://www.readbyqxmd.com/read/29404945/electronic-health-records-a-quadruple-win-a-quadruple-failure-or-simply-time-for-a-reboot
#2
EDITORIAL
Michael Hochman
No abstract text is available yet for this article.
February 5, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29374436/rebooting-the-generally-recognized-as-safe-gras-approach-for-food-additive-safety-in-the-us
#3
Thomas Hartung
The US Food and Drug Administration (FDA) has premarket review authority over food additives, but a food manufacturer may, according to the legislation, intentionally add a substance to human food or animal food without their premarket review or approval if the substance is generally recognized, among qualified experts, to be safe under the conditions of its intended use. Generally recognized as safe (GRAS) implies that the current scientific community agrees on the adequacy of how data is generated. This system has come under public pressure because of doubts as to its efficiency and the FDA's recent GRAS rule is part of the response...
2018: ALTEX
https://www.readbyqxmd.com/read/29356627/rebooting-bioresilience-a-multi-omics-approach-to-tackle-global-catastrophic-biological-risks-and-next-generation-biothreats
#4
Manousos E Kambouris, Yiannis Manoussopoulos, Maria Kantzanou, Aristea Velegraki, Georgios Gaitanis, Michalis Arabatzis, George P Patrinos
Global Catastrophic Biological Risks (GCBRs) refer to biological events-natural, deliberate, and accidental-of a global and lasting impact. This challenges the life scientists to raise their game on two hitherto neglected innovation frontiers: a veritable "futures" thinking to "think the unthinkable," and "systems thinking" so as to see both the trees and the forest when it comes to GCBRs. This innovation analysis article outlines the promise of Omics systems science biotechnologies, for example, to deploy rapid fire diagnostics for health security crises at GCBR level, possibly involving neopathogens and/or incurring epidemics (e...
January 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29317774/pancreatic-cancer-in-2017-rebooting-pancreatic-cancer-knowledge-and-treatment-options
#5
Alexander Semaan, Anirban Maitra
No abstract text is available yet for this article.
January 10, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29300036/a-reboot-for-chronic-fatigue-syndrome-research
#6
Amy Maxmen
No abstract text is available yet for this article.
January 4, 2018: Nature
https://www.readbyqxmd.com/read/29298913/cross-genus-rebooting-of-custom-made-synthetic-bacteriophage-genomes-in-l-form-bacteria
#7
Samuel Kilcher, Patrick Studer, Christina Muessner, Jochen Klumpp, Martin J Loessner
Engineered bacteriophages provide powerful tools for biotechnology, diagnostics, pathogen control, and therapy. However, current techniques for phage editing are experimentally challenging and limited to few phages and host organisms. Viruses that target Gram-positive bacteria are particularly difficult to modify. Here, we present a platform technology that enables rapid, accurate, and selection-free construction of synthetic, tailor-made phages that infect Gram-positive bacteria. To this end, custom-designed, synthetic phage genomes were assembled in vitro from smaller DNA fragments...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29178820/nucleases-acting-at-stalled-forks-how-to-reboot-the-replication-program-with-a-few-shortcuts
#8
Philippe Pasero, Alessandro Vindigni
In a lifetime, a human being synthesizes approximately 2×1016 meters of DNA, a distance that corresponds to 130,000 times the distance between the Earth and the Sun. This daunting task is executed by thousands of replication forks, which progress along the chromosomes and frequently stall when they encounter DNA lesions, unusual DNA structures, RNA polymerases, or tightly-bound protein complexes. To complete DNA synthesis before the onset of mitosis, eukaryotic cells have evolved complex mechanisms to process and restart arrested forks through the coordinated action of multiple nucleases, topoisomerases, and helicases...
November 27, 2017: Annual Review of Genetics
https://www.readbyqxmd.com/read/29052637/reboot-for-the-ai-revolution
#9
Yuval Noah Harari
No abstract text is available yet for this article.
October 17, 2017: Nature
https://www.readbyqxmd.com/read/29049282/behavioral-intervention-to-reduce-opioid-overdose-among-high-risk-persons-with-opioid-use-disorder-a-pilot-randomized-controlled-trial
#10
RANDOMIZED CONTROLLED TRIAL
Phillip Oliver Coffin, Glenn-Milo Santos, Tim Matheson, Emily Behar, Chris Rowe, Talia Rubin, Janelle Silvis, Eric Vittinghoff
OBJECTIVE: The United States is amidst an opioid epidemic, including synthetic opioids that may result in rapid death, leaving minimal opportunity for bystander rescue. We pilot tested a behavioral intervention to reduce the occurrence of opioid overdose among opioid dependent persons at high-risk for subsequent overdose. MATERIALS AND METHODS: We conducted a single-blinded randomized-controlled trial of a repeated dose motivational interviewing intervention (REBOOT) to reduce overdose versus treatment as usual, defined as information and referrals, over 16 months at the San Francisco Department of Public Health from 2014-2016...
2017: PloS One
https://www.readbyqxmd.com/read/28903813/rebooting-healthcare-information-technology-downtime-management
#11
Julie Bulson, Mark Van Dyke, Nicole Skibinski
Healthcare, like many other industries, has become reliant on technology to manage daily operations. Often, technology downtimes are managed within the information technology departments to ensure the technical staff can return the hardware or software to the end users as quickly as possible. However, if managed strictly through IT departments, such incidents lack critical communication components and an understanding of the impact on end users. This paper argues that such technological incidents need to be managed not just rapidly but also in conjunction with the emergency preparedness department...
January 1, 2017: Journal of Business Continuity & Emergency Planning
https://www.readbyqxmd.com/read/28811584/nanopriming-technology-for-enhancing-germination-and-starch-metabolism-of-aged-rice-seeds-using-phytosynthesized-silver-nanoparticles
#12
Wuttipong Mahakham, Ajit K Sarmah, Santi Maensiri, Piyada Theerakulpisut
Application of nanomaterials for agriculture is relatively new as compared to their use in biomedical and industrial sectors. In order to promote sustainable nanoagriculture, biocompatible silver nanoparticles (AgNPs) have been synthesized through green route using kaffir lime leaf extract for use as nanopriming agent for enhancing seed germination of rice aged seeds. Results of various characterization techniques showed the successful formation of AgNPs which were capped with phytochemicals present in the plant extract...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28708357/-mentalizing-in-liaison-psychiatry
#13
Paco Prada, Pierre Cole, Guido Bondolfi, Nader Perroud, Martin Debbané
In the past few years, there has been an increased and widespread interest for Mentalization-Based Therapies (MBTs). Although originally developed by Anthony Bateman and Peter Fonagy for the treatment of Borderline Personality Disorder (BPD), the scope of MBTs has now been broadened and is relevant in liaison psychiatry, not only to cope with personality disorders or phenomena such as emotional dysregulation and suicidal behaviours, but also because being ill and expericencieng a dependency-laden relationship with health workers tend to reduce mentalization capacities, thereby increasing the probability of misunderstandings, conflicts, treatment drop-outs or medical errors...
February 8, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28571636/the-swing-of-%C3%AE-blockers-time-for-a-system-reboot
#14
EDITORIAL
Borja Ibáñez, Sergio Raposeiras-Roubin, José M García-Ruiz
No abstract text is available yet for this article.
June 6, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28562503/rebooting-kirkpatrick-integrating-information-system-theory-into-the-evaluation-of-web-based-continuing-professional-development-interventions-for-interprofessional-education
#15
Nelson Shen, Shira Yufe, Omid Saadatfard, Sanjeev Sockalingam, David Wiljer
INTRODUCTION: Information system research has stressed the importance of theory in understanding how user perceptions can motivate the use and adoption of technology such as web-based continuing professional development programs for interprofessional education (WCPD-IPE). A systematic review was conducted to provide an information system perspective on the current state of WCPD-IPE program evaluation and how current evaluations capture essential theoretical constructs in promoting technology adoption...
April 2017: Journal of Continuing Education in the Health Professions
https://www.readbyqxmd.com/read/28533435/enzymatic-inactivation-of-endogenous-igg-by-ides-enhances%C3%A2-therapeutic-antibody-efficacy
#16
Sofia Järnum, Anna Runström, Robert Bockermann, Lena Winstedt, Max Crispin, Christian Kjellman
Endogenous plasma IgG sets an immunological threshold that dictates the activity of tumor-directed therapeutic antibodies. Saturation of cellular antibody receptors by endogenous antibody limits antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody dependent cellular phagocytosis (ADCP). Here we show how enzymatic cleavage of IgG using the bacterial enzyme IdeS can be utilized to empty both high and low affinity Fcγ-receptors and clear the entire endogenous antibody pool. Using in vitro models, tumor animal models as well as ex vivo analysis of sera collected during a previous clinical trial with IdeS, we show how clearing of competing plasma antibody levels with IdeS unblocks cellular antibody receptors...
May 22, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28522330/e-health-in-2017-rebooting-cardiovascular-care
#17
EDITORIAL
Costas Tsioufis
No abstract text is available yet for this article.
March 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/28324079/value-based-purchasing-time-for-reboot-or-time-to-move-on
#18
Ashish K Jha
No abstract text is available yet for this article.
March 21, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28252381/vancouver-coastal-health-s-second-generation-health-strategy-a-need-for-a-reboot
#19
Jeffrey R Masuda, Sophy Chan
In this commentary, we consider the motivations and implications of Vancouver Coastal Health's place-based population health strategy called the Downtown Eastside Second Generation Health Strategy (2GHS) in light of a broader historical view of shifting values in population and public health and structural health reforms in Canada over the past three decades. We argue that the tone and content of the 2GHS signals a shift towards a neoliberal clientelist model of health that treats people as patients and the DTES as a site of clinical encounter rather than as a community in its own right...
March 1, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28167937/antiviral-defenses-in-plants-through-genome-editing
#20
REVIEW
Gustavo Romay, Claude Bragard
Plant-virus interactions based-studies have contributed to increase our understanding on plant resistance mechanisms, providing new tools for crop improvement. In the last two decades, RNA interference, a post-transcriptional gene silencing approach, has been used to induce antiviral defenses in plants with the help of genetic engineering technologies. More recently, the new genome editing systems (GES) are revolutionizing the scope of tools available to confer virus resistance in plants. The most explored GES are zinc finger nucleases, transcription activator-like effector nucleases, and clustered regularly interspaced short palindromic repeats/Cas9 endonuclease...
2017: Frontiers in Microbiology
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