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Ashish K Jha
No abstract text is available yet for this article.
March 21, 2017: JAMA: the Journal of the American Medical Association
Jeffrey R Masuda, Sophy Chan
In this commentary, we consider the motivations and implications of Vancouver Coastal Health's place-based population health strategy called the Downtown Eastside Second Generation Health Strategy (2GHS) in light of a broader historical view of shifting values in population and public health and structural health reforms in Canada over the past three decades. We argue that the tone and content of the 2GHS signals a shift towards a neoliberal clientelist model of health that treats people as patients and the DTES as a site of clinical encounter rather than as a community in its own right...
March 1, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
Gustavo Romay, Claude Bragard
Plant-virus interactions based-studies have contributed to increase our understanding on plant resistance mechanisms, providing new tools for crop improvement. In the last two decades, RNA interference, a post-transcriptional gene silencing approach, has been used to induce antiviral defenses in plants with the help of genetic engineering technologies. More recently, the new genome editing systems (GES) are revolutionizing the scope of tools available to confer virus resistance in plants. The most explored GES are zinc finger nucleases, transcription activator-like effector nucleases, and clustered regularly interspaced short palindromic repeats/Cas9 endonuclease...
2017: Frontiers in Microbiology
Mark Peplow
No abstract text is available yet for this article.
December 28, 2016: ACS Central Science
André M Striegel
No abstract text is available yet for this article.
August 2016: Chromatographia
Dennis Normile
No abstract text is available yet for this article.
November 18, 2016: Science
Steven R Steinhubl, Evan D Muse, Paddy M Barrett, Eric J Topol
No abstract text is available yet for this article.
August 20, 2016: Lancet
Meghan K Eberhardt, Ashlesha Deshpande, Joseph Fike, Rebecca Short, Kimberli A Schmidt, Shelley A Blozis, Mark R Walter, Peter A Barry
There is accumulating evidence that the viral interleukin-10 (vIL-10) ortholog of both human and rhesus cytomegalovirus (HCMV and RhCMV, respectively) suppresses the functionality of cell types that are critical to contain virus dissemination and help shape long-term immunity during the earliest virus-host interactions. In particular, exposure of macrophages, peripheral blood mononuclear cells, monocyte-derived dendritic cells, and plasmacytoid dendritic cells to vIL-10 suppresses multiple effector functions including, notably, those that link innate and adaptive immune responses...
November 1, 2016: Journal of Virology
Kana Inoue, Yumi Yamamoto, Genji Sugamura
We tested possible intrapersonal effects of a sigh as a psychological "resetter/rebooter." Fifty-eight undergraduates were randomly assigned to a sigh or a normal exhalation (control) group. We asked participants on each task to model the experimenter demonstrating how to exhale air into a small plastic bag for breathing manipulation under the pretext that we were interested in the exhaled gas in stressful situations. Results revealed that the sigh group did not experience more relief (as shown by prolonged reaction time) after exposure to threat stimuli, but showed more persistence on a highly-difficult puzzle task (p = ...
June 2016: Shinrigaku Kenkyu: the Japanese Journal of Psychology
Peng Wu, Yuandai Luo, Lifang Zhen, Xianda Hu, Ying Shang, Yinuo Liao, Huiyuan Xue, Fukai Huang, Wei Xiao
Rannasangpei (RSNP) is used as a therapeutic agent in the treatment of cardiovascular diseases, neurological disorders, and neurodegeneration in China; however, its potential use in the treatment of vascular dementia (VD) was unclear. In this study, our aim was to examine the neuroprotective effect of RSNP in a VD rat model, which was induced by permanent bilateral common carotid artery occlusion (2VO). Four-week administration with two doses of RSNP was investigated in our study. Severe cognitive deficit in the VD model, which was confirmed in Morris water maze (MWM) test, was significantly restored by the administration of RSNP...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
Sean Munoz, Mabel Guzman-Rodriguez, Jun Sun, Yong-Guo Zhang, Curtis Noordhof, Shu-Mei He, Emma Allen-Vercoe, Erika C Claud, Elaine O Petrof
Using a murine Salmonella model of colitis, we recently reported that mice receiving a community of defined gut microbiota (MET-1) lost less weight, had reduced systemic inflammation and splenic S. typhimurium infection, and decreased neutrophil infiltration in the cecum, compared to vehicle controls. In addition, animals receiving MET-1 exhibited preserved tight junction protein expression (Zonula occludens-1, claudin-1), suggesting important effects on barrier function. In this addendum, we describe additional in vitro experiments examining effects of MET-1, as well as in vivo experiments demonstrating that MET-1 is protective in a DSS model of colitis after administration of antibiotics...
July 3, 2016: Gut Microbes
Erik Stokstad
No abstract text is available yet for this article.
May 6, 2016: Science
Joe Roman, James Kraska
No abstract text is available yet for this article.
March 18, 2016: Science
Jennifer Kuzma
No abstract text is available yet for this article.
March 10, 2016: Nature
Nan Li, C Yan Cheng
mTOR (mammalian target of rapamycin) is one of the most important signaling molecules in mammalian cells which regulates an array of cellular events, ranging from cell metabolism to cell proliferation. Based on the association of mTOR with the core component proteins, such as Raptor or Rictor, mTOR can become the mTORC1 (mammalian target of rapamycin complex 1) or mTORC2, respectively. Studies have shown that during the epithelial cycle of spermatogenesis, mTORC1 promotes remodeling and restructuring of the blood-testis barrier (BTB) in vitro and in vivo, making the Sertoli cell tight junction (TJ)-permeability barrier "leaky"; whereas mTORC2 promotes BTB integrity, making the Sertoli cell TJ-barrier "tighter"...
September 2016: Histology and Histopathology
Matteo Vatta
No abstract text is available yet for this article.
July 2016: Trends in Cardiovascular Medicine
Yi Seul Lee, Ji Young Bae, Hye Young Koo, Young Boo Lee, Won San Choi
We present the synthesis of polydopamine particle-gold composites (PdopP-Au) and unique release of Au@Pdop core@shell nanoparticles (NPs) from the PdopP-Au upon external stimuli. The PdopP-Au was prepared by controlled synthesis of AuNPs on the Pdop particles. Upon near infrared (NIR) irradiation or NaBH4 treatment on the PdopP-Au, the synthesized AuNPs within the PdopPs could be burst-released as a form of Au@Pdop NPs. The PdopP-Au composite showed outstanding photothermal conversion ability under NIR irradiation due to the ultrahigh loading of the AuNPs within the PdopPs, leading to a remote-controlled explosion of the PdopP-Au and rapid formation of numerous Au@Pdop NPs...
2016: Scientific Reports
Alexandra Witze
No abstract text is available yet for this article.
January 14, 2016: Nature
A Collin de l'Hortet, K Takeishi, J Guzman-Lepe, K Handa, K Matsubara, K Fukumitsu, K Dorko, S C Presnell, H Yagi, A Soto-Gutierrez
Liver transplantation, either a partial liver from a living or deceased donor or a whole liver from a deceased donor, is the only curative therapy for severe end-stage liver disease. Only one-third of those on the liver transplant waiting list will be transplanted, and the demand for livers is projected to increase 23% in the next 20 years. Consequently, organ availability is an absolute constraint on the number of liver transplants that can be performed. Regenerative therapies aim to enhance liver tissue repair and regeneration by any means available (cell repopulation, tissue engineering, biomaterials, proteins, small molecules, and genes)...
June 2016: American Journal of Transplantation
Nan Li, Dolores D Mruk, Ka-Wai Mok, Michelle W M Li, Chris K C Wong, Will M Lee, Daishu Han, Bruno Silvestrini, C Yan Cheng
Earlier studies have shown that rats treated with an acute dose of 1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide (adjudin, a male contraceptive under development) causes permanent infertility due to irreversible blood-testis barrier (BTB) disruption even though the population of undifferentiated spermatogonia remains similar to normal rat testes, because spermatogonia fail to differentiate into spermatocytes to enter meiosis. Since other studies have illustrated the significance of connexin 43 (Cx43)-based gap junction in maintaining the homeostasis of BTB in the rat testis and the phenotypes of Sertoli cell-conditional Cx43 knockout mice share many of the similarities of the adjudin-treated rats, we sought to examine if overexpression of Cx43 in these adjudin-treated rats would reseal the disrupted BTB and reinitiate spermatogenesis...
April 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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