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https://www.readbyqxmd.com/read/29769170/design-and-rationale-for-a-parent-led-intervention-to-increase-fruit-and-vegetable-intake-in-young-childhood-cancer-survivors-reboot-protocol-for-a-pilot-study
#1
Lauren Touyz, Jennifer Cohen, Claire Wakefield, Allison Grech, Sarah Garnett, Paayal Gohil, Richard Cohn
BACKGROUND: Poor dietary habits are common among childhood cancer survivors, despite increasing their risk of cardio metabolic complications after cancer treatment. Here, we describe the design and rationale for a pilot telephone-based, parent-led intervention aimed at increasing fruit and vegetable intake in young cancer survivors (Reboot). OBJECTIVE: This pilot study aims to assess the feasibility and acceptability of delivering evidence-based telephone support to parents of childhood cancer survivors...
May 16, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29731100/endotype-driven-care-pathways-in-patients-with-chronic-rhinosinusitis
#2
REVIEW
Claus Bachert, Nan Zhang, Peter W Hellings, Jean Bousquet
Chronic rhinosinusitis (CRS) has been differentiated clinically into CRS without nasal polyps and CRS with nasal polyps, with both forms subjected to glucocorticosteroid and antibiotic treatments and, if not successful, to nasal and sinus surgery tailored to endoscopic and computed tomographic scan findings. The elaboration of endotypes based on pathomechanisms involving different immune responses offers new possibilities in terms of prediction of prognosis and risks and sophisticated guidance in personalized pharmacotherapy, surgical approaches, and innovative treatment approaches in the CRS field with various biologics...
May 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29674576/risk-based-reboot-for-global-lab-biosafety
#3
Kazunobu Kojima, Catherine Makison Booth, Kathrin Summermatter, Allan Bennett, Marianne Heisz, Stuart D Blacksell, Michelle McKinney
No abstract text is available yet for this article.
April 20, 2018: Science
https://www.readbyqxmd.com/read/29669852/cholesterol-cancer-and-rebooting-a-treatment-for-athlete-s-foot
#4
REVIEW
Ngee Kiat Chua, Hudson W Coates, Andrew J Brown
A key enzyme in cholesterol synthesis is placed firmly on the oncogenic map and demonstrated to be a potential therapeutic target in liver cancer by repurposing a common antifungal agent (Liu et al , this issue).
April 18, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29593711/regenerating-immunotolerance-in-multiple-sclerosis-with-autologous-hematopoietic-stem-cell-transplant
#5
REVIEW
Jennifer C Massey, Ian J Sutton, David D F Ma, John J Moore
Multiple sclerosis (MS) is an inflammatory disorder of the central nervous system where evidence implicates an aberrant adaptive immune response in the accrual of neurological disability. The inflammatory phase of the disease responds to immunomodulation to varying degrees of efficacy; however, no therapy has been proven to arrest progression of disability. Recently, more intensive therapies, including immunoablation with autologous hematopoietic stem cell transplantation (AHSCT), have been offered as a treatment option to retard inflammatory disease, prior to patients becoming irreversibly disabled...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29565329/time-for-a-reboot-in-congress
#6
Andrew A Rosenberg
No abstract text is available yet for this article.
February 20, 2018: Scientific American
https://www.readbyqxmd.com/read/29490162/rebooting-human-immunology
#7
Mark M Davis, Petter Brodin
Recent progress in both conceptual and technological approaches to human immunology have rejuvenated a field that has long been in the shadow of the inbred mouse model. This is a healthy development both for the clinical relevance of immunology and for the fact that it is a way to gain access to the wealth of phenomenology in the many human diseases that involve the immune system. This is where we are likely to discover new immunological mechanisms and principals, especially those involving genetic heterogeneity or environmental influences that are difficult to model effectively in inbred mice...
April 26, 2018: Annual Review of Immunology
https://www.readbyqxmd.com/read/29407244/who-is-more-flexible-awareness-of-changing-context-but-not-working-memory-capacity-modulates-inhibitory-control
#8
Shan-Chuan Teng, Hsuan-Fu Chao, Yunn-Wen Lien
The present study examines how a person's working memory capacity (WMC) and awareness of change in context influences modulating inhibitory control. Context was manipulated by changing the predictive validity of a prime to a following target (i.e., the proportion of prime repetition) across three phases in a single-prime negative priming task. The prime was a distractor for the following target when the proportion was 25% (in the first and third phases) and a useful cue when the proportion rose to 75% (in the second phase)...
April 2018: Acta Psychologica
https://www.readbyqxmd.com/read/29404945/electronic-health-records-a-quadruple-win-a-quadruple-failure-or-simply-time-for-a-reboot
#9
EDITORIAL
Michael Hochman
No abstract text is available yet for this article.
April 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29374436/rebooting-the-generally-recognized-as-safe-gras-approach-for-food-additive-safety-in-the-us
#10
Thomas Hartung
The US Food and Drug Administration (FDA) has premarket review authority over food additives, but a food manufacturer may, according to the legislation, intentionally add a substance to human food or animal food without their premarket review or approval if the substance is generally recognized, among qualified experts, to be safe under the conditions of its intended use. Generally recognized as safe (GRAS) implies that the current scientific community agrees on the adequacy of how data is generated. This system has come under public pressure because of doubts as to its efficiency and the FDA's recent GRAS rule is part of the response...
2018: ALTEX
https://www.readbyqxmd.com/read/29356627/rebooting-bioresilience-a-multi-omics-approach-to-tackle-global-catastrophic-biological-risks-and-next-generation-biothreats
#11
Manousos E Kambouris, Yiannis Manoussopoulos, Maria Kantzanou, Aristea Velegraki, Georgios Gaitanis, Michalis Arabatzis, George P Patrinos
Global Catastrophic Biological Risks (GCBRs) refer to biological events-natural, deliberate, and accidental-of a global and lasting impact. This challenges the life scientists to raise their game on two hitherto neglected innovation frontiers: a veritable "futures" thinking to "think the unthinkable," and "systems thinking" so as to see both the trees and the forest when it comes to GCBRs. This innovation analysis article outlines the promise of Omics systems science biotechnologies, for example, to deploy rapid fire diagnostics for health security crises at GCBR level, possibly involving neopathogens and/or incurring epidemics (e...
January 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29317774/pancreatic-cancer-in-2017-rebooting-pancreatic-cancer-knowledge-and-treatment-options
#12
Alexander Semaan, Anirban Maitra
No abstract text is available yet for this article.
February 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29300036/a-reboot-for-chronic-fatigue-syndrome-research
#13
Amy Maxmen
No abstract text is available yet for this article.
January 4, 2018: Nature
https://www.readbyqxmd.com/read/29298913/cross-genus-rebooting-of-custom-made-synthetic-bacteriophage-genomes-in-l-form-bacteria
#14
Samuel Kilcher, Patrick Studer, Christina Muessner, Jochen Klumpp, Martin J Loessner
Engineered bacteriophages provide powerful tools for biotechnology, diagnostics, pathogen control, and therapy. However, current techniques for phage editing are experimentally challenging and limited to few phages and host organisms. Viruses that target Gram-positive bacteria are particularly difficult to modify. Here, we present a platform technology that enables rapid, accurate, and selection-free construction of synthetic, tailor-made phages that infect Gram-positive bacteria. To this end, custom-designed, synthetic phage genomes were assembled in vitro from smaller DNA fragments...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29178820/nucleases-acting-at-stalled-forks-how-to-reboot-the-replication-program-with-a-few-shortcuts
#15
Philippe Pasero, Alessandro Vindigni
In a lifetime, a human being synthesizes approximately 2×1016 meters of DNA, a distance that corresponds to 130,000 times the distance between the Earth and the Sun. This daunting task is executed by thousands of replication forks, which progress along the chromosomes and frequently stall when they encounter DNA lesions, unusual DNA structures, RNA polymerases, or tightly-bound protein complexes. To complete DNA synthesis before the onset of mitosis, eukaryotic cells have evolved complex mechanisms to process and restart arrested forks through the coordinated action of multiple nucleases, topoisomerases, and helicases...
November 27, 2017: Annual Review of Genetics
https://www.readbyqxmd.com/read/29052637/reboot-for-the-ai-revolution
#16
Yuval Noah Harari
No abstract text is available yet for this article.
October 17, 2017: Nature
https://www.readbyqxmd.com/read/29049282/behavioral-intervention-to-reduce-opioid-overdose-among-high-risk-persons-with-opioid-use-disorder-a-pilot-randomized-controlled-trial
#17
RANDOMIZED CONTROLLED TRIAL
Phillip Oliver Coffin, Glenn-Milo Santos, Tim Matheson, Emily Behar, Chris Rowe, Talia Rubin, Janelle Silvis, Eric Vittinghoff
OBJECTIVE: The United States is amidst an opioid epidemic, including synthetic opioids that may result in rapid death, leaving minimal opportunity for bystander rescue. We pilot tested a behavioral intervention to reduce the occurrence of opioid overdose among opioid dependent persons at high-risk for subsequent overdose. MATERIALS AND METHODS: We conducted a single-blinded randomized-controlled trial of a repeated dose motivational interviewing intervention (REBOOT) to reduce overdose versus treatment as usual, defined as information and referrals, over 16 months at the San Francisco Department of Public Health from 2014-2016...
2017: PloS One
https://www.readbyqxmd.com/read/28903813/rebooting-healthcare-information-technology-downtime-management
#18
Julie Bulson, Mark Van Dyke, Nicole Skibinski
Healthcare, like many other industries, has become reliant on technology to manage daily operations. Often, technology downtimes are managed within the information technology departments to ensure the technical staff can return the hardware or software to the end users as quickly as possible. However, if managed strictly through IT departments, such incidents lack critical communication components and an understanding of the impact on end users. This paper argues that such technological incidents need to be managed not just rapidly but also in conjunction with the emergency preparedness department...
January 1, 2017: Journal of Business Continuity & Emergency Planning
https://www.readbyqxmd.com/read/28811584/nanopriming-technology-for-enhancing-germination-and-starch-metabolism-of-aged-rice-seeds-using-phytosynthesized-silver-nanoparticles
#19
Wuttipong Mahakham, Ajit K Sarmah, Santi Maensiri, Piyada Theerakulpisut
Application of nanomaterials for agriculture is relatively new as compared to their use in biomedical and industrial sectors. In order to promote sustainable nanoagriculture, biocompatible silver nanoparticles (AgNPs) have been synthesized through green route using kaffir lime leaf extract for use as nanopriming agent for enhancing seed germination of rice aged seeds. Results of various characterization techniques showed the successful formation of AgNPs which were capped with phytochemicals present in the plant extract...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28708357/-mentalizing-in-liaison-psychiatry
#20
Paco Prada, Pierre Cole, Guido Bondolfi, Nader Perroud, Martin Debbané
In the past few years, there has been an increased and widespread interest for Mentalization-Based Therapies (MBTs). Although originally developed by Anthony Bateman and Peter Fonagy for the treatment of Borderline Personality Disorder (BPD), the scope of MBTs has now been broadened and is relevant in liaison psychiatry, not only to cope with personality disorders or phenomena such as emotional dysregulation and suicidal behaviours, but also because being ill and expericencieng a dependency-laden relationship with health workers tend to reduce mentalization capacities, thereby increasing the probability of misunderstandings, conflicts, treatment drop-outs or medical errors...
February 8, 2017: Revue Médicale Suisse
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