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https://www.readbyqxmd.com/read/28523921/combination-of-h120-and-1-96-avian-infectious-bronchitis-virus-vaccine-strains-protect-chickens-against-challenge-with-is-1494-06-variant-2-like-infectious-bronchitis-virus
#1
M Habibi, V Karimi, A G Langeroudi, S A Ghafouri, M Hashemzadeh, R K Farahani, H Maghsoudloo, H Abdollahi, P Seifouri
Avian infectious bronchitis (IB) is a worldwide chicken disease, caused by avian infectious bronchitis virus (IBV) which infects all commercial poultry lines. The present study was done to evaluate protection caused by two different serotype vaccines (Massachusetts and 793/B) in order to evaluate protection against challenge with IS/1494/06-like virus (variant 2-like virus), which is prevalent in the Middle East. SPF chickens were divided into four groups (n = 20). First and second group as negative control group and non-vaccinated-challenged group received no vaccine...
2017: Acta Virologica
https://www.readbyqxmd.com/read/28518040/highly-pathogenic-avian-influenza-virus-h5n8-clade-2-3-4-4-infection-in-migratory-birds-egypt
#2
Abdullah A Selim, Ahmed M Erfan, Naglaa Hagag, Ali Zanaty, Abdel-Hafez Samir, Mohamed Samy, Ahmed Abdelhalim, Abdel-Satar A Arafa, Mohamed A Soliman, Momtaz Shaheen, Essam M Ibraheem, Ibrahim Mahrous, Mohamed K Hassan, Mahmoud M Naguib
We isolated highly pathogenic avian influenza virus (H5N8) of clade 2.3.4.4 from the common coot (Fulica atra) in Egypt, documenting its introduction into Africa through migratory birds. This virus has a close genetic relationship with subtype H5N8 viruses circulating in Europe. Enhanced surveillance to detect newly emerging viruses is warranted.
June 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28515301/the-influenza-a-virus-ns1-protein-promotes-efficient-nuclear-export-of-unspliced-viral-m1-mrna
#3
Carina F Pereira, Eliot K C Read, Helen M Wise, Maria J Amorim, Paul Digard
Influenza A virus mRNAs are transcribed by the viral RNA-dependent RNA polymerase in the cell nucleus before being exported to the cytoplasm for translation. Segment 7 produces two major transcripts: an unspliced mRNA that encodes the M1 matrix protein and a spliced transcript that encodes the M2 ion channel. Export of both mRNAs is dependent on the cellular NXF1/TAP pathway but it is unclear how they are recruited to the export machinery or how the intron-containing but unspliced M1 mRNA bypasses the normal quality control checkpoints...
May 17, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28515300/a-novel-a-h7n2-influenza-virus-isolated-from-a-veterinarian-caring-for-cats-in-a-new-york-city-animal-shelter-causes-mild-disease-and-transmits-poorly-in-the-ferret-model
#4
Jessica A Belser, Joanna A Pulit-Penaloza, Xiangjie Sun, Nicole Brock, Claudia Pappas, Hannah M Creager, Hui Zeng, Terrence M Tumpey, Taronna R Maines
In December 2016, a low pathogenic avian influenza (LPAI) A(H7N2) virus was identified as the causative source of an outbreak in a cat shelter in New York City, which subsequently spread to multiple shelters in New York and Pennsylvania. One person with occupational exposure to infected cats became infected with the virus, representing the first LPAI H7N2 human infection in North America since 2003. Considering the close contact that frequently occurs between companion animals and humans, it was critical to assess the relative risk of this novel virus to public health...
May 17, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28514082/universal-label-free-in-process-quantification-of-influenza-virus-like-particles
#5
Sofia B Carvalho, Mafalda G Moleirinho, David Wheatley, John Welsh, René Gantier, Paula M Alves, Cristina Peixoto, Manuel J T Carrondo
Virus-like particles (VLPs) are becoming established as vaccines, in particular for influenza pandemics, increasing the interest in the development of VLPs manufacturing bioprocess. However, for complex VLPs, the analytical tools used for quantification are not yet able to keep up with the bioprocess progress. Currently, quantification for Influenza relies on traditional methods: hemagglutination assay or Single Radial Immunodiffusion. These analytical technologies are time-consuming, cumbersome, and not supportive of efficient downstream process development and monitoring...
May 17, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28513330/the-pathogenesis-of-clade-2-3-4-4-h5-highly-pathogenic-avian-influenza-viruses-in-ruddy-duck-oxyura-jamaicensis-and-lesser-scaup-aythya-affinis
#6
Erica Spackman, Diann J Prosser, Mary J Pantin-Jackwood, Alicia M Berlin, Christopher B Stephens
Waterfowl are the natural hosts of avian influenza virus (AIV) and disseminate the virus worldwide through migration. Historically, surveillance and research efforts for AIV in waterfowl have focused on dabbling ducks. The role of diving ducks in AIV ecology has not been well characterized. In this study, we examined the relative susceptibility and pathogenicity of clade 2.3.4.4 H5 highly pathogenic (HP) AIV (HPAIV) in two species of diving ducks. Juvenile and adult Ruddy Duck (Oxyura jamaicensis) and juvenile Lesser Scaup (Aythya affinis) were intranasally inoculated with A/Northern Pintail/WA/40964/2014 H5N2 HPAIV...
May 17, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28513329/serologic-detection-of-subtype-specific-antibodies-to-influenza-a-viruses-in-southern-sea-otters-enhydra-lutris-nereis
#7
Alyssa M Capuano, Melissa Miller, David E Stallknecht, Megan Moriarty, Magdalena Plancarte, Erin Dodd, Francesca Batac, Walter M Boyce
There are approximately 3,000 southern sea otters (Enhydra lutris nereis) in the nearshore environment along the California coast, and the species is classified as Threatened under the Endangered Species Act. We tested sera from 661 necropsied southern sea otters sampled from 1997 to 2015 to determine overall exposure to influenza A viruses (IAVs) and to identify subtype-specific antibody responses. Using an enzyme-linked immunosorbent assay (ELISA), antibodies to IAV nucleoproteins were detected in 160 (24...
May 17, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28511853/immunologic-evaluation-of-10-different-adjuvants-for-use-in-vaccines-for-chickens-against-highly-pathogenic-avian-influenza-virus
#8
Nazir Ahmed Lone, Erica Spackman, Darrell Kapczynski
Avian influenza viruses (AIV) are a threat to poultry production worldwide. Vaccination is utilized as a component of control programs for both high pathogenicity (HP) and low pathogenicity (LP) AIV. Over 95% of all AIV vaccine used in poultry are inactivated, adjuvanted products. To identify the best formulations for chickens, vaccines were prepared with beta-propiolactone (BPL) inactivated A/British Columbia/314514-1/2004 H7N3 LP AIV using ten commercially available or experimental adjuvants. Each vaccine formulation was evaluated for immunogenicity in chickens...
May 13, 2017: Vaccine
https://www.readbyqxmd.com/read/28511269/the-role-of-birds-in-arboviral-disease-surveillance-in-harris-county-and-the-city-of-houston-texas
#9
Lauren Wilkerson, Martin Reyna Nava, Cheryl Battle-Freeman, Amelia Travassos da Rosa, Hilda Guzman, Robert Tesh, Mustapha Debboun
Avian arboviral surveillance is an integral part of any disease-based integrated mosquito control program. The Harris County Public Health Mosquito and Vector Control Division has performed arboviral surveillance in the wild birds of Harris County and the City of Houston since 1965. Blood samples from live trapped birds were tested for arboviral antibodies to West Nile virus (WNV), St. Louis encephalitis, Eastern equine encephalitis, and Western equine encephalitis. A dead bird surveillance program was created in 2002 with the arrival of WNV in Harris County...
January 2017: U.S. Army Medical Department Journal
https://www.readbyqxmd.com/read/28509437/detection-of-avian-influenza-virus-from-cloacal-swabs-using-a-disposable-well-gate-fet-sensor
#10
Sungwook Park, Jaebin Choi, Minhong Jeun, Yongdeok Kim, Seong-Su Yuk, Sang Kyung Kim, Chang-Seon Song, Seok Lee, Kwan Hyi Lee
Current methods to detect avian influenza viruses (AIV) are time consuming and lo inw sensitivity, necessitating a faster and more sensitive sensor for on-site epidemic detection in poultry farms and urban population centers. This study reports a field effect transistor (FET) based AIV sensor that detects nucleoproteins (NP) within 30 minutes, down to an LOD of 10(3) EID50 mL(-1) from a live animal cloacal swab. Previously reported FET sensors for AIV detection have not targeted NPs, an internal protein shared across multiple strains, due to the difficulty of field-effect sensing in a highly ionic lysis buffer...
May 16, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28508225/plasmid-based-reverse-genetics-of-influenza-a-virus
#11
Daniel R Perez, Matthew Angel, Ana Silvia Gonzalez-Reiche, Jefferson Santos, Adebimpe Obadan, Luis Martinez-Sobrido
Influenza A viruses have broad host range with a recognized natural reservoir in wild aquatic birds. From this reservoir, novel strains occasionally emerge with the potential to establish stable lineages in other avian and mammalian species, including humans. Understanding the molecular changes that allow influenza A viruses to change host range is essential to better assess their animal and public health risks. Reverse genetics systems have transformed the ability to manipulate and study negative strand RNA viruses...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28508215/reverse-genetics-system-for-the-avian-coronavirus-infectious-bronchitis-virus
#12
Erica Bickerton, Sarah M Keep, Paul Britton
We have developed a reverse genetics system for the avian coronavirus infectious bronchitis virus (IBV) in which a full-length cDNA corresponding to the IBV genome is inserted into the vaccinia virus genome under the control of a T7 promoter sequence. Vaccinia virus as a vector for the full-length IBV cDNA has the advantage that modifications can be introduced into the IBV cDNA using homologous recombination, a method frequently used to insert and delete sequences from the vaccinia virus genome. Here, we describe the use of transient dominant selection as a method for introducing modifications into the IBV cDNA that has been successfully used for the substitution of specific nucleotides, deletion of genomic regions, and exchange of complete genes...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28503168/generation-and-comprehensive-analysis-of-host-cell-interactome-of-the-pa-protein-of-the-highly-pathogenic-h5n1-avian-influenza-virus-in-mammalian-cells
#13
Zhao Gao, Jiao Hu, Yanyan Liang, Qian Yang, Kun Yan, Dong Liu, Xiaoquan Wang, Min Gu, Xiaowen Liu, Shunlin Hu, Zenglei Hu, Huimou Liu, Wenbo Liu, Sujuan Chen, Daxin Peng, Xin-An Jiao, Xiufan Liu
Accumulating data have identified the important roles of PA protein in replication and pathogenicity of influenza A virus (IAV). Identification of host factors that interact with the PA protein may accelerate our understanding of IAV pathogenesis. In this study, using immunoprecipitation assay combined with liquid chromatography-tandem mass spectrometry, we identified 278 human cellular proteins that might interact with PA of H5N1 IAV. Gene Ontology annotation revealed that the identified proteins are highly associated with viral translation and replication...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28499553/nasal-delivery-of-protollin-adjuvanted-h5n1-vaccine-induces-enhanced-systemic-as-well-as-mucosal-immunity-in-mice
#14
Weiping Cao, Jin Hyang Kim, Adrian J Reber, Mary Hoelscher, Jessica A Belser, Xiuhua Lu, Jacqueline M Katz, Shivaprakash Gangappa, Martin Plante, David S Burt, Suryaprakash Sambhara
Sporadic, yet frequent human infections with avian H5N1 influenza A viruses continue to pose a potential pandemic threat. Poor immunogenicity of unadjuvanted H5N1 vaccines warrants developing novel adjuvants and formulations as well as alternate delivery systems to improve their immunogenicity and efficacy. Here, we show that Protollin, a nasal adjuvant composed of Neisseria meningitides outer membrane proteins non-covalently linked to Shigella flexneri 2a lipopolysaccharide, is a potent nasal adjuvant for an inactivated split virion H5N1 clade 1 A/Viet Nam1203/2004 (A/VN/1203/04) vaccine in a mouse model...
June 5, 2017: Vaccine
https://www.readbyqxmd.com/read/28495648/complete-genome-sequences-of-two-avian-infectious-bronchitis-viruses-isolated-in-egypt-evidence-for-genetic-drift-and-genetic-recombination-in-the-circulating-viruses
#15
Hassanein H Abozeid, Anandan Paldurai, Sunil K Khattar, Manal A Afifi, Magdy F El-Kady, Ayman H El-Deeb, Siba K Samal
Avian infectious bronchitis virus (IBV) is highly prevalent in chicken populations and is responsible for severe economic losses to poultry industry worldwide. In this study, we report the complete genome sequences of two IBV field strains, CU/1/2014 and CU/4/2014, isolated from vaccinated chickens in Egypt in 2014. The genome lengths of the strains CU/1/2014 and CU/4/2014 were 27,615 and 27,637 nucleotides, respectively. Both strains have a common genome organization in the order of 5'-UTR-1a-1b-S-3a-3b-E-M-4b-4c-5a-5b-N-6b-UTR-poly(A) tail-3'...
May 8, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28494344/pa-x-protein-contributes-to-virulence-of-triple-reassortant-h1n2-influenza-virus-by-suppressing-early-immune-responses-in-swine
#16
Guanlong Xu, Xuxiao Zhang, Qinfang Liu, Guoxia Bing, Zhe Hu, Honglei Sun, Xin Xiong, Ming Jiang, Qiming He, Yu Wang, Juan Pu, Xin Guo, Hanchun Yang, Jinhua Liu, Yipeng Sun
Previous studies have identified a functional role of PA-X for influenza viruses in mice and avian species; however, its role in swine remains unknown. Toward this, we constructed PA-X deficient virus (Sw-FS) in the background of a Triple-reassortment (TR) H1N2 swine influenza virus (SIV) to assess the impact of PA-X in viral virulence in pigs. Expression of PA-X in TR H1N2 SIV enhanced viral replication and host protein synthesis shutoff, and inhibited the mRNA levels of type I IFNs and proinflammatory cytokines in porcine cells...
May 8, 2017: Virology
https://www.readbyqxmd.com/read/28494003/p2y6-receptors-are-involved-in-mediating-the-effect-of-inactivated-avian-influenza-virus-h5n1-on-il-6-cxcl8-mrna-expression-in-respiratory-epithelium
#17
Nawiya Huipao, Suparerk Borwornpinyo, Suwimon Wiboon-Ut, Craig R Campbell, Il-Ha Lee, Siriphun Hiranyachattada, Chonlaphat Sukasem, Arunee Thitithanyanont, Chumpol Pholpramool, David I Cook, Anuwat Dinudom
One of the key pathophysiologies of H5N1 infection is excessive proinflammatory cytokine response (cytokine storm) characterized by increases in IFN-β, TNF-α, IL-6, CXCL10, CCL4, CCL2 and CCL5 in the respiratory tract. H5N1-induced cytokine release can occur via an infection-independent mechanism, however, detail of the cellular signaling involved is poorly understood. To elucidate this mechanism, the effect of inactivated (β-propiolactone-treated) H5N1 on the cytokine and chemokine mRNA expression in 16HBE14o- human respiratory epithelial cells was investigated...
2017: PloS One
https://www.readbyqxmd.com/read/28493975/molecular-characterization-expression-of-chicken-tbk1-gene-and-its-effect-on-irf3-signaling-pathway
#18
Yan Wang, Yue Yin, Xi Lan, Fei Ye, Kai Tian, Xiaoling Zhao, Huadong Yin, Diyan Li, Hengyong Xu, Yiping Liu, Qing Zhu
TRAF family member-associated NF-κB activator (TANK)-binding kinase1 (TBK1) is a serine-threonine kinase at the crossroads of multiple interferon (IFN)-inducing signaling pathways in innate immunity. The importance of TBK1 in antiviral immunity is well established in mammal models, but in chicken, the molecular characterization and potential function of TBK1 remain unclear. In the present study, the open-reading frame (ORF) of chicken TBK1 (chTBK1) was cloned and characterized. The sequencing results revealed that the chTBK1 ORF consists of 2190 base pairs (bp) encoding a deduced protein of 729 amino acid residues...
2017: PloS One
https://www.readbyqxmd.com/read/28493054/the-dynamics-of-a-seir-sirc-antigenic-drift-influenza-model
#19
Fajar Adi-Kusumo
We consider the dynamics of an influenza model with antigenic drift mechanism. Antigenic drift is an antigen mutation on the skin surface of the influenza virus that do not produce a new virus strain. The mutation produces the same virus but with slightly different antigens that cannot be recognized by the immune receptors formed by the previous infection. There are some type of influenza that involve the interaction between two populations such as human and animal. In this paper, we construct an influenza model with antigenic drift mechanism on the human population that has interaction with the animal population...
May 10, 2017: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/28490598/development-of-clade-specific-and-broadly-reactive-live-attenuated-influenza-virus-vaccines-against-rapidly-evolving-h5-subtype-viruses
#20
Kobporn Boonnak, Yumiko Matsuoka, Weijia Wang, Amorsolo L Suguitan, Zhongying Chen, Myeisha Paskel, Mariana Baz, Ian Moore, Hong Jin, Kanta Subbarao
We have developed pandemic live attenuated influenza vaccines (pLAIV) against clade 1 H5N1 viruses on an Ann Arbor cold-adapted (ca) backbone that induced long-term immune memory. In 2015, many human infections caused by a new clade (2.2.1.1) of goose/Guangdong (gs/GD) lineage H5N1 viruses were reported in Egypt that prompted updating of the H5N1 pLAIV. We explored two strategies to generate suitable pLAIVs: first to modify the hemagglutinin gene of a highly pathogenic wild-type (wt) clade 2.2.1.1 virus A/Egypt/N03434/2009 (Egy/09) (H5N1) with its unmodified neuraminidase (NA) gene; this virus was designated Egy/09 ca The second approach was to select a low pathogenicity avian influenza H5 virus that elicited antibodies that cross-reacted with a broad range of H5 viruses, including the Egypt H5N1 viruses and contained a novel NA subtype for humans...
May 10, 2017: Journal of Virology
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