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https://www.readbyqxmd.com/read/28724791/mitochondrial-dna-enriched-microparticles-promote-acute-on-chronic-alcoholic-neutrophilia-and-hepatotoxicity
#1
Yan Cai, Ming-Jiang Xu, Erik H Koritzinsky, Zhou Zhou, Wei Wang, Haixia Cao, Peter St Yuen, Ruth A Ross, Robert A Star, Suthat Liangpunsakul, Bin Gao
Over the last several years, one of the major advances in the field of alcoholic liver disease research was the discovery that binge alcohol consumption induced neutrophilia and hepatic neutrophil infiltration in chronically ethanol-fed mice and human subjects with excessive alcohol use (EAU); however, the underlying mechanisms remain obscure. Here, we demonstrated that chronic EAU patients with a history of recent excessive drinking (EAU + RD) had higher serum levels of mitochondrial DNA (mtDNA)-enriched microparticles (MPs) than EAU without recent drinking (EAU - RD) and healthy controls, which correlated positively with circulating neutrophils...
July 20, 2017: JCI Insight
https://www.readbyqxmd.com/read/28723385/grey-zone-urinary-incontinence
#2
Andrea Tubaro, Arjun K Nambiar
Providing high-quality evidence in the field of urinary incontinence is difficult because the value of diagnostic tests must be evaluated through the filter of treatment outcome, and surgical treatments include an unavoidable amount of intrinsic variability. The scientific community should be commended for the gigantic effort made over the years to provide evidence upon which proper patient management can be based.
August 2016: European Urology Focus
https://www.readbyqxmd.com/read/28720143/mhc-class-ii-expression-and-potential-antigen-presenting-cells-in-the-retina-during-experimental-autoimmune-uveitis
#3
Deborah A Lipski, Rémi Dewispelaere, Vincent Foucart, Laure E Caspers, Matthieu Defrance, Catherine Bruyns, François Willermain
BACKGROUND: Controversy exists regarding which cell types are responsible for autoantigen presentation in the retina during experimental autoimmune uveitis (EAU) development. In this study, we aimed to identify and characterize the retinal resident and infiltrating cells susceptible to express major histocompatibility complex (MHC) class II during EAU. METHODS: EAU was induced in C57BL/6 mice by adoptive transfer of autoreactive lymphocytes from IRBP1-20-immunized animals...
July 18, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28716318/surveillance-strategies-for-neurogenic-lower-urinary-tract-dysfunction
#4
REVIEW
Randy A Vince, Adam P Klausner
Patients with neurogenic lower urinary tract dysfunction (NLUTD) experience significant morbidity and mortality due to urological complications including upper tract damage and bladder malignancy. This has led to increased surveillance in patients NLUTD. This article discusses the methods available for surveillance of patients with NLUTD and pulls information from the largest and most established organizations that have produced evidence-based surveillance guidelines for NLUTD. These organizations include the Paralyzed Veterans of America (PVA), US Department of Veterans Affairs, European Association of Urology (EAU), The NICE organization from the UK, and cites additional literature not been included in these documents...
August 2017: Urologic Clinics of North America
https://www.readbyqxmd.com/read/28712790/prognostic-factors-for-tumor-recurrence-in-patients-with-clinical-stage-i-seminoma-undergoing-surveillance-a-systematic-review
#5
REVIEW
Friedemann Zengerling, Frank Kunath, Katrin Jensen, Christian Ruf, Stefanie Schmidt, Annabel Spek
OBJECTIVE: To systematically evaluate evidence on prognostic factors for tumor recurrence in patients with clinical stage I seminoma undergoing surveillance. METHODS: Systematic literature search conducted of Medline, Web of Science, Cochrane Library, and the conference proceedings of the ASCO, AUA, and EAU meetings (last search: October 2016), according to our prospectively registered protocol (PROSPERO registration number CRD42014009434). Identified records were reviewed according to the Cochrane Method Group of Prognosis Reviews recommendations and the PRISMA reporting guideline...
July 13, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28693386/development-methodology-of-the-novel-endoscopic-stone-treatment-step-1-est-s1-training-assessment-curriculum
#6
Domenico Veneziano, Kamran Ahmed, Ben S E P Van Cleynenbreugel, Ali Serdar Gözen, Joan Palou, Kemal Sarica, Evangelos N Liatsikos, Francesco Sanguedolce, Patrick Honeck, Mario Alvarez-Maestro, Athanasios Papatsoris, Panagiotis Kallidonis, Francesco Greco, Alberto Breda, Bhaskar Somani
Background Simulation based technical-skill assessment is a core topic of debate, especially in high-risk environments. After the introduction of the E-BLUS exam for basic laparoscopy, no more technical training/assessment urological protocols have been developed in Europe. Objective We describe the methodology used in the development of the novel Endoscopic Stone Treatment step 1 (EST s1) assessment curriculum. Materials and Methods The "full life cycle curriculum development" template was followed for curriculum development...
July 10, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28684304/sodium-butyrate-regulates-th17-treg-cell-balance-to-ameliorate-uveitis-via-the-nrf2-ho-1-pathway
#7
Xiaoqing Chen, Wenru Su, Taoshang Wan, Jianfeng Yu, Wenjie Zhu, Fen Tang, Guangming Liu, Nancy Olsen, Dan Liang, Song Guo Zheng
Autoimmune uveitis, a group of potentially blinding intraocular inflammatory diseases, remains a therapeutic challenge for ophthalmologists. Butyrates, which belong to the short-chain fatty acid family, possess immunomodulatory properties and therapeutic potential in several inflammatory disorders. However, the roles of butyrates in uveitis and their underlying immunomodulatory mechanisms remain elusive. Here, we report that treatment with sodium butyrate (NaB) significantly attenuated the ocular inflammatory response in mice with experimental autoimmune uveitis (EAU) at 14days after immunization, with significant decreases in inflammatory cell infiltration and inflammatory cytokine production in the retinas...
July 3, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28659587/effects-of-mesenchymal-stem-cell-derived-exosomes-on-experimental-autoimmune-uveitis
#8
Lingling Bai, Hui Shao, Hongxing Wang, Zhihui Zhang, Chang Su, Lijie Dong, Bo Yu, Xiteng Chen, Xiaorong Li, Xiaomin Zhang
We previously demonstrated that mesenchymal stem cells (MSCs) ameliorated experimental autoimmune uveoretinitis (EAU) in rats. Recently, MSC-derived exosomes (MSC-Exo) were thought to carry functions of MSCs. In this study, we tested the effect of local administration of human MSC-Exo on established EAU in the same species. Rats with EAU induced by immunization with interphotoreceptor retinol-binding protein 1177-1191 peptide were treated by periocular injections of increasing doses of MSC-Exo starting at the disease onset for 7 consecutive days...
June 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28651790/re-multicenter-investigation-of-the-micro-organisms-involved-in-penile-prosthesis-infection-an-analysis-of-the-efficacy-of-the-aua-and-eau-guidelines-for-penile-prosthesis-prophylaxis
#9
https://www.readbyqxmd.com/read/28631121/-prudent-use-of-antimicrobial-prophylaxis-prevention-of-increasing-antibiotic-resistance
#10
REVIEW
C Hein, A Pilatz, F M E Wagenlehner
BACKGROUND: The use of peri-operative antimicrobial prophylaxis during urological procedures to prevent postoperative complications is very common. OBJECTIVES: What kind of recommendations for reasonable use of peri-operative antimicrobial prophylaxis during urological procedures to prevent increasing antibiotic resistance and postoperative complications exist? METHODS: Review of evidence-based recommendations from literature and current Guidelines of the EAU...
June 19, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28618690/re-summary-of-european-association-of-urology-eau-guidelines-on-neuro-urology
#11
Alan J Wein
No abstract text is available yet for this article.
July 2017: Journal of Urology
https://www.readbyqxmd.com/read/28606275/-study-on-the-choice-of-medication-time-and-with-drawal-time-of-intermittent-endocrine-therapy-for-prostate-cancer
#12
D Chen, M Xia
Objective: To determine the best timing of discontinuance of intermittent endocrine therapy for prostate cancer (PCa). Methods: From February 2012 to September 2014, 120 PCa patients confirmed by biopsy at the Department of Urology Surgery, Beijing Shijitan Hospital Affiliated to Capital Medical University, were included. They were divided into high-, moderate- and low-risk groups according to EAU Guidelines in 2015. All patients received intermittent endocrine therapy. When the serum level of prostate-specific antigen (PSA) dropped to 0...
June 13, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28589400/radical-prostatectomy-for-high-risk-localized-or-node-positive-prostate-cancer-removing-the-primary
#13
REVIEW
Justin T Matulay, G Joel DeCastro
PURPOSE OF REVIEW: We reviewed the literature to determine what role, if any, radical prostatectomy should play in the treatment of high-risk and/or node-positive prostate cancer. RECENT FINDINGS: The AUA, NCCN, and EAU all include radical prostatectomy as a treatment option for high-risk prostate cancer based on evidence that has shown improvements in biochemical-free and disease-specific survival. Lymph node-positive patients may also derive benefit from radical prostatectomy with lymph node dissection, however, only retrospective studies with high risk of selection bias have been published to date...
July 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28588651/testosterone-suppression-with-a-unique-form-of-leuprorelin-acetate-as-a-solid-biodegradable-implant-in-patients-with-advanced-prostate-cancer-results-from-four-trials-and-comparison-with-the-traditional-leuprorelin-acetate-microspheres-formulation
#14
Mladen Solarić, Anders Bjartell, Ursula Thyroff-Friesinger, Davide Meani
BACKGROUND: There are two slow-release ready-to-use forms of leuprorelin acetate (1-month and 3-month) that are available as solid, biodegradable implants for the treatment of advanced, hormone-sensitive prostate cancer. These implants have been shown to be as effective as traditional leuprorelin acetate microspheres for achieving successful testosterone suppression (⩽0.5 ng/ml) and lowering prostate-specific antigen (PSA) levels. Here we further evaluate testosterone suppression levels from four clinical trials evaluating the 3-month leuprorelin implant, including analysis below the European Association of Urology (EAU) castration level (<0...
December 2017: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/28537409/-ureterointestinal-anastomosis-in-urinary-diversion-current-opinion
#15
J Doležel
Uretero-intestinal anastomosis (UIA) is one of the most critical points for the occurrence of severe complications of intestinal urinary diversion. Perfection of the current techniques and development of new UIA methods are motivated by the effort to reduce both early and late post-surgical complications. The necessity of using antireflux UIA, especially with an orthotopic neobladder, is controversial: according to some authors, antireflux UIA of any type generally increases, in comparison with reflux UIA, the risk of obstruction that endangers renal function more than the urine reflux itself...
2017: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/28505892/re-oncologic-outcomes-of-kidney-sparing-surgery-versus-radical-nephroureterectomy-for-upper-tract-urothelial-carcinoma-a-systematic-review-by-the-eau-non-muscle-invasive-bladder-cancer-guidelines-panel
#16
https://www.readbyqxmd.com/read/28501709/calcium-ion-coordinated-dexamethasone-supramolecular-hydrogel-as-therapeutic-alternative-for-control-of-non-infectious-uveitis
#17
Wei Wu, Zhaoliang Zhang, Taotao Xiong, Wenguang Zhao, Rou Jiang, Hao Chen, Xingyi Li
Supramolecular hydrogel formed by the self-assembly of therapeutic agents have received considerable attention due to its high drug payload and carrier-free features. Herein, we constructed a dexamethasone sodium phosphate (Dex) supramolecular hydrogel in combination of Dex and calcium ion (Ca(2+)) and further demonstrated its therapeutic efficacy in the control of ocular inflammation. The developed supramolecular hydrogel was thoroughly characterized by rheology, TEM, FTIR and XRD. Calcium ions and Dex concentration had markedly influence on the sol-gel transition behaviour of hydrogel and the proposed Dex supramolecular hydrogel displayed thixotropic property...
May 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28494937/msc-derived-extracellular-vesicles-attenuate-immune-responses-in-two-autoimmune-murine-models-type-1-diabetes-and-uveoretinitis
#18
Taeko Shigemoto-Kuroda, Joo Youn Oh, Dong-Ki Kim, Hyun Jeong Jeong, Se Yeon Park, Hyun Ju Lee, Jong Woo Park, Tae Wan Kim, Su Yeon An, Darwin J Prockop, Ryang Hwa Lee
Accumulating evidence shows that extracellular vesicles (EVs) produced by mesenchymal stem/stromal cells (MSCs) exert their therapeutic effects in several disease models. We previously demonstrated that MSCs suppress autoimmunity in models of type 1 diabetes (T1D) and experimental autoimmune uveoretinitis (EAU). Therefore, here, we investigated the therapeutic potential of MSC-derived EVs using our established mouse models for autoimmune diseases affecting the pancreas and the eye: T1D and EAU. The data demonstrate that MSC-derived EVs effectively prevent the onset of disease in both T1D and EAU...
May 9, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28492293/european-association-of-urology-32nd-annual-congress-march-24-28-2017-london-uk
#19
R Sharman
The European Association of Urology (EAU) Congress is Europe's biggest urological event and this year's meeting, in London, UK, brought together more than 13,000 participants from over 100 countries to discuss the latest research in this field. With 5 days' worth of lectures, debates, learning courses, presentations and live surgeries the congress provided plenty of opportunity to learn from the 1,400 experts presenting, as well as to network with international peers.
April 2017: Drugs of Today
https://www.readbyqxmd.com/read/28457662/corrigendum-re-early-recurrence-patterns-following-totally-intracorporeal-robot-assisted-radical-cystectomy-results-from-the-eau-robotic-urology-section-erus-scientific-working-group-eur-urol-2017-71-723-6
#20
Justin W Collins, Abolfazl Hosseini, Christofer Adding, Tommy Nyberg, Anthony Koupparis, Edward Rowe, Matthew Perry, Rami Issa, Martin C Schumacher, Carl Wijburg, Abdullah E Canda, Mevlana Balbay, Karel Decaestecker, Christian Schwentner, Arnulf Stenzl, Sebastian Edeling, Saša Pokupić, Fredrik D'Hondt, Alexander Mottrie, Peter N Wiklund
No abstract text is available yet for this article.
April 27, 2017: European Urology
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