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https://www.readbyqxmd.com/read/28413126/consensus-statement-of-the-european-urology-association-and-the-european-urogynaecological-association-on-the-use-of-implanted-materials-for-treating-pelvic-organ-prolapse-and-stress-urinary-incontinence
#1
REVIEW
Christopher R Chapple, Francisco Cruz, Xavier Deffieux, Alfredo L Milani, Salvador Arlandis, Walter Artibani, Ricarda M Bauer, Fiona Burkhard, Linda Cardozo, David Castro-Diaz, Jean Nicolas Cornu, Jan Deprest, Alfons Gunnemann, Maria Gyhagen, John Heesakkers, Heinz Koelbl, Sheila MacNeil, Gert Naumann, Jan-Paul W R Roovers, Stefano Salvatore, Karl-Dietrich Sievert, Tufan Tarcan, Frank Van der Aa, Francesco Montorsi, Manfred Wirth, Mohamed Abdel-Fattah
CONTEXT: Surgical nonautologous meshes have been used for several decades to repair abdominal wall herniae. Implantable materials have been adopted for the treatment of female and male stress urinary incontinence (SUI) and female pelvic organ prolapse (POP). OBJECTIVE: A consensus review of existing data based on published meta-analyses and reviews. EVIDENCE ACQUISITION: This document summarises the deliberations of a consensus group meeting convened by the European Association of Urology (EAU) and the European Urogynecological Association, to explore the current evidence relating to the use of polypropylene (PP) materials used for the treatment of SUI and POP, with reference to the 2016 EAU guidelines (European Association of Urology 2016), the European Commission's SCENIHR report on the use of surgical meshes (SCENIHR 2015), other available high-quality evidence, guidelines, and national recommendations...
April 13, 2017: European Urology
https://www.readbyqxmd.com/read/28403595/factors-affecting-surgical-margin-positivity-in-robotic-assisted-radical-prostatectomy
#2
Mustafa Yuksel, Kaan Karamık, Hakan Anıl, Ekrem Islamoglu, Mutlu Ates, Murat Savas
OBJECTIVES: After radical prostatectomy, surgical margin positivity is an important indicator of biochemical recurrence and progression. In our study we want to compare the surgical margin positivity rates for retropubic radical prostatectomy (RRP) and robotic assisted radical prostatectomy (RALP) and investigate the factors affecting surgical margin positivity in RALP. MATERIALS AND METHODS: Data from 78 RRP and 62 RALP patients operated from 2011 May to 2016 March were retrospectively screened...
March 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28399699/prognostic-and-discriminative-power-of-the-7th-tnm-classification-for-patients-with-surgically-treated-papillary-renal-cell-carcinoma-results-of-a-multi-institutional-validation-study-corona-subtype-project
#3
Matthias May, Cristian Surcel, Umberto Capitanio, Paolo Dell'Oglio, Tobias Klatte, Shahrokh Shariat, Thorsten Ecke, Ingmar Wolff, Daniel Vergho, Nina Wagener, Nina Huck, Sascha Pahernik, Stefan Zastrow, Manfred Wirth, Hendrik Borgmann, Axel Haferkamp, Mireia Musquera, Laura M Krabbe, Edwin Herrmann, Anna Scavuzzo, Cristian Mirvald, Georg Hutterer, Richard Zigeuner, Christian G Stief, Raphaela Waidelich, Luca Cindolo, Krystina Kalusova, Sabine D Brookman-May
OBJECTIVE: Studies on the prognostic reliability of the Union for International Cancer Control tumor, node, metastasis (TNM) staging system for renal cell carcinoma (RCC) predominantly focus on clear-cell RCC. Therefore, the aim of this study was to investigate whether the oncological prognosis of surgically treated papillary RCC (papRCC) patients is reliably given by the current TNM system, by analyzing the largest database reported to date. MATERIALS AND METHODS: Data on 2325 papRCC patients who underwent surgical treatment in 1984- 2015 were collated from 17 international centers (median follow-up 47 months)...
April 12, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28385455/prostate-cancer-and-the-john-west-effect
#4
EDITORIAL
(no author information available yet)
The first results of the UK ProtecT study have been published. A total of 1643 men with localised prostate cancer were randomised between active monitoring, radical prostatectomy, and external-beam radiotherapy. Comparisons between treatments showed no differences between surgery and radiotherapy in terms of cancer-specific survival and overall survival. Moreover, the patient-reported outcomes indicate that although the patterns of treatment-related side effects differ markedly according to the modality, neither surgery nor radiotherapy appears to be "kinder" overall...
April 3, 2017: European Urology
https://www.readbyqxmd.com/read/28380224/utilization-of-corn-cob-and-tio2-photocatalyst-thin-films-for-dyes-removal
#5
Hui-Yee Gan, Li-Eau Leow, Siew-Teng Ong
The effectiveness of using TiO2 and corn cob films to remove Malachite Green oxalate (MG) and Acid Yellow 17 (AY 17) from binary dye solution was studied. The immobilization method in this study can avoid the filtration step which is not suited for practical applications. Batch studies were performed under different experimental conditions and the parameters studied involved initial pH of dye solution, initial dye concentration and contact time and reusability. The equilibrium data of MG and AY 17 conform to Freundlich and Langmuir isotherm model, respectively...
2017: Acta Chimica Slovenica
https://www.readbyqxmd.com/read/28366700/eau-and-aua-suo-guidelines-on-risk-categories-for-non-muscle-invasive-bladder-cancer-may-lead-to-overtreatment-for-low-grade-ta-bladder-tumors
#6
Zachary Klaassen, Mark S Soloway
No abstract text is available yet for this article.
March 30, 2017: Urology
https://www.readbyqxmd.com/read/28332318/a-novel-bispecific-molecule-delivered-by-recombinant-aav2-suppresses-ocular-inflammation-and-choroidal-neovascularization
#7
Yiming Li, Ping Zhu, Amrisha Verma, Tuhina Prasad, Hongxin Deng, Dechao Yu, Qiuhong Li
Elevated vascular endothelial growth factor (VEGF) and complement activation are implicated in the pathogenesis of different ocular diseases. The objective of this study was to investigate the hypothesis that dual inhibition of both VEGF and complement activation would confer better protection against ocular inflammation and neovascularization. In this study, we engineered a secreted chimeric VEGF inhibitor domain (VID), a complement inhibitor domain (CID) and a dual inhibitor (ACVP1). Vectors expressing these three inhibitors were constructed and packaged into AAV2 (sextY-F) particles...
March 22, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28322234/propsa-and-the-prostate-health-index-as-predictive-markers-for-aggressiveness-in-low-risk-prostate-cancer-results-from-an-international-multicenter-study
#8
I Heidegger, H Klocker, R Pichler, A Pircher, W Prokop, E Steiner, C Ladurner, E Comploj, A Lunacek, D Djordjevic, A Pycha, E Plas, W Horninger, J Bektic
BACKGROUND: One of the major challenges in prostate cancer (PCa) treatment is distinguishing insignificant PCa from those forms that need active treatment. We evaluated the impact of PSA isoforms on risk stratification in patients with low-risk PCa as well as in active surveillance (AS) candidates who underwent radical prostatectomy. METHODS: A total of 112 patients with biopsy confirmed Gleason score (GS) 6 PCa of four different international institutions were prospectively enrolled in the study...
March 21, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28319477/emerging-techniques-in-truly-minimal-invasive-treatment-options-of-benign-prostatic-obstruction
#9
Karl-Dietrich Sievert, Thomas Kunit
PURPOSE OF REVIEW: Benign prostatic enlargement is a common age-related condition, affecting over 50% of men aged more than 60 years. Side effects of medical therapy and significant morbidity of transurethral resection of the prostate and open surgery led to the development of so-called minimally invasive procedures, with the aim to be efficient but with less morbidity and shorter or no hospitalization. For this review, a systematic literature was performed. We report recent results in different treatment options for benign prostate hypoplasia (BPH) and recommend the best minimal-invasive treatment for BPH...
May 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28317247/establishing-the-pathways-and-indications-for-performing-isotope-bone-scans-in-newly-diagnosed-intermediate-risk-localised-prostate-cancer-results-from-a-large-contemporaneous-cohort
#10
Gokul Vignesh KandaSwamy, Adam Bennett, Krishna Narahari, Owen Hughes, John Rees, Howard Kynaston
OBJECTIVE: To establish the pattern of isotope bone scan (BS) positivity in a large contemporaneous cohort of newly diagnosed localised prostate cancer (PCa) patients and compare with the European Association of Urology (EAU) guidelines. BACKGROUND: Imaging guidelines and clinical practice of using BS to stage newly diagnosed patients with intermediate risk (IR) localised PCa are not uniform in the literature. PATIENTS AND METHODS: All newly diagnosed PCa patients were discussed in a specialist multidisciplinary team (sMDT) meeting and were prospectively entered in a database...
March 20, 2017: BJU International
https://www.readbyqxmd.com/read/28292388/tailored-metabolic-workup-for-urolithiasis-the-debate-continues
#11
M. Hammad Ather, M. Nasir Sulaiman, Imran Siddiqui, Tahmeena Siddiqui
Urolithiasis is one of the commonest afflictions of the urinary tract. Stones are of various chemical compositions, some share some common etiology; but most are specific to the structure and composition of stone. In view of highly recurrent nature of this condition, it is logical to have strategies for prevention. However, due to multiple factors most patients receive no or fragmented information on prevention. The current controversy is to the extent of metabolic workup in adult first time stone former. This requires longitudinal studies to show benefit in prevention strategies...
February 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28287852/cyclosporine-a-historical-perspective-on-its-role-in-the-treatment-of-noninfectious-uveitis
#12
Wendy M Smith
The history of cyclosporine and uveitis is intertwined with the development of experimental autoimmune uveitis (EAU) animal models and the understanding that T lymphocytes play a major role in the pathogenesis of uveitis. The early studies of CsA in uveitis also demonstrated the power of collaborative efforts in translational research. Dr. Robert Nussenblatt and his colleagues were the first to show that CsA can inhibit EAU. Over many years after the initial CsA experiments, Dr. Nussenblatt's group as well as others continued to study CsA under experimental conditions as well as in clinical trials with human patients...
March 13, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28285790/diagnosis-and-treatment-for-clinically-localized-prostate-cancer-adherence-to-the-european-association-of-urology-clinical-guidelines-in-a-nationwide-population-based-study-gescap-group
#13
F Gómez-Veiga, A Rodríguez-Antolín, B Miñana, C Hernández, J F Suárez, J M Fernández-Gómez, M Unda, J Burgos, A Alcaraz, P Rodríguez, R Medina, J Castiñeiras, C Moreno, E Pedrosa, J M Cózar
OBJECTIVE: To assess the adherence to European Association of Urology (EAU) guidelines in the management of prostate cancer (PCa) in Spain. PATIENTS AND METHODS: Epidemiological, population-based, study including a national representative sample of 3,918 incident patients with histopathological confirmation during 2010; 95% of the patient's sample was followed up for at least one year. Diagnosis along with treatment related variables (for localized PCa -low, intermediate, high and locally-advanced by D'Amico risk stratification) was recorded...
March 9, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28278321/in-vivo-bioluminescence-imaging-for-longitudinal-monitoring-of-inflammation-in-animal-models-of-uveitis
#14
Michal B Gutowski, Leslie Wilson, Russell N Van Gelder, Kathryn L Pepple
Purpose: We develop a quantitative bioluminescence assay for in vivo longitudinal monitoring of inflammation in animal models of uveitis. Methods: Three models of experimental uveitis were induced in C57BL/6 albino mice: primed mycobacterial uveitis (PMU), endotoxin-induced uveitis (EIU), and experimental autoimmune uveitis (EAU). Intraperitoneal injection of luminol sodium salt, which emits light when oxidized, provided the bioluminescence substrate. Bioluminescence images were captured by a PerkinElmer In Vivo Imaging System (IVIS) Spectrum and total bioluminescence was analyzed using Living Image software...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28267649/intravitreal-injection-of-anti-interleukin-il-6-antibody-attenuates-experimental-autoimmune-uveitis-in-mice
#15
Jan Tode, Elisabeth Richert, Stefan Koinzer, Alexa Klettner, Ute Pickhinke, Christoph Garbers, Stefan Rose-John, Bernhard Nölle, Johann Roider
PURPOSE: To evaluate the effect of an intravitreally applied anti-IL-6 antibody for the treatment of experimental autoimmune uveitis (EAU). METHODS: EAU was induced in female B10.RIII mice by Inter-Photoreceptor-Binding-Protein (IRBP) in complete Freund's adjuvant, boosted by Pertussis toxin. Single blinded intravitreal injections of anti-IL-6 antibody were applied 5-7days as well as 8-10days (3day interval) after EAU induction into the randomized treatment eye and phosphate buffered saline (PBS) into the fellow control eye...
March 3, 2017: Cytokine
https://www.readbyqxmd.com/read/28261206/the-hmgb1-cxcl12-complex-promotes-inflammatory-cell-infiltration-in-uveitogenic-t-cell-induced-chronic-experimental-autoimmune-uveitis
#16
Juan Yun, Guomin Jiang, Yunsong Wang, Tong Xiao, Yuan Zhao, Deming Sun, Henry J Kaplan, Hui Shao
It is largely unknown how invading autoreactive T cells initiate the pathogenic process inside the diseased organ in organ-specific autoimmune diseases. In experimental autoimmune uveitis (EAU) induced by uveitogenic, interphotoreceptor retinoid-binding protein (IRBP)-specific T cells (tEAU) in mice, we have previously reported that high mobility group box 1 (HMGB1) released as a consequence of the direct interaction between IRBP-specific T cells and retinal parenchymal cells is an early and critical mediator in induction of intraocular inflammation...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28248972/novel-cd28-antagonist-mpeg-pv1-fab-mitigates-experimental-autoimmune-uveitis-by-suppressing-cd4-t-lymphocyte-activation-and-ifn-%C3%AE-production
#17
Pedro Henrique Papotto, Eliana Blini Marengo, Luiz Roberto Sardinha, Karina Inácio Carvalho, Ana Eduarda Zulim de Carvalho, Sheyla Castillo-Mendez, Carina Calixto Jank, Bernard Vanhove, Anna Carla Goldberg, Luiz Vicente Rizzo
Autoimmune Uveitis is an important chronic inflammatory disease and a leading cause of impaired vision and blindness. This ocular autoimmune disorder is mainly mediated by T CD4+ lymphocytes poising a TH1 phenotype. Costimulatory molecules are known to play an important role on T cell activation and therefore represent interesting therapeutical targets for autoimmune disorders. CD28 is the prototypical costimulatory molecule for T lymphocytes, and plays a crucial role in the initiation, and maintenance of immune responses...
2017: PloS One
https://www.readbyqxmd.com/read/28248059/-extracorporeal-and-contact-lithotripsy-for-large-ureteral-stones
#18
M I Kogan, I I Belousov, Akef Maarouf Yassine Akef Maarouf Yassine
Expert panels of AUA and EAU defined highly effective approaches to surgical treatment of ureterolithiasis and recommended extracorporeal and contact lithotripsy as the main options. Therapeutic strategy for ureteral stones measuring less than 10 mm is clearly defined and supported by the Russian Society of Urology. At the same time, the views of researchers on the management of large ureteral stones vary. This literature review provides information on the results of extracorporeal shock-wave lithotripsy and contact ureterolithotripsy of large stones located in various parts of the ureter...
December 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28243965/parent-compliance-a-bad-predictor-of-resolution-and-a-problem-in-the-application-of-eau-guidelines-on-vesicoureteral-reflux-in-children
#19
Radu Alexandru Prisca, Horea Gozar, Ana Maria Prisca, Cosmin Moldovan, Angela Borda
Primary vesicoureteral reflux (VUR) is a controversial pathology. Current management of VUR is ruled by EAU guidelines elaborated in 2012. They defined and analyzed the risk factors and enunciated three risk groups, developing the initial treatment indications. Continuous antibiotic prophylaxis (CAP) is recommended as the initial treatment option in patients classified in moderate-risk group without low urinary tract disorder. The compliance with medication use is a concern for using CAP. The aim of the present study is to quantify the compliance of the parents of VUR patients, to analyze its impact on treatment and the applicability of EAU guidelines in our patients...
February 27, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28241314/retinal-pigment-epithelial-cells-suppress-phagolysosome-activation-in-macrophages
#20
Eric Wang, Yoona Choe, Tat Fong Ng, Andrew W Taylor
Purpose: The eye is an immune-privileged microenvironment that has adapted several mechanisms of immune regulation to prevent inflammation. One of these potential mechanisms is retinal pigment epithelial cells (RPE) altering phagocytosis in macrophages. Methods: The conditioned media of RPE eyecups from eyes of healthy mice and mice with experimental autoimmune uveitis (EAU) were used to treat primary macrophage phagocytizing pHrodo bacterial bioparticles. In addition, the neuropeptides were depleted from the conditioned media of healthy RPE eyecups and used to treat phagocytizing macrophages...
February 1, 2017: Investigative Ophthalmology & Visual Science
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