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https://www.readbyqxmd.com/read/28058776/guideline-of-guidelines-non-muscle-invasive-bladder-cancer
#1
REVIEW
Solomon L Woldu, Aditya Bagrodia, Yair Lotan
Non-muscle invasive bladder cancer (NMIBC) represents the vast majority of bladder cancer diagnoses, however this definition represents a spectrum of disease with a variable clinical course notable for significant risk of recurrence and potential for progression. Management involves risk-adapted strategies of cystoscopic surveillance and intravesical therapy with a goal of bladder preservation when safe to do so. Multiple organizational guidelines exist to help practitioners manage this complicated disease process, however adherence to management principles amongt practicing urologists is reportedly low...
January 6, 2017: BJU International
https://www.readbyqxmd.com/read/28054134/ultrasonographic-evidence-of-gatekeeper%C3%A2-prosthesis-migration-in-patients-treated-for-faecal-incontinence-a-case-series
#2
F de la Portilla, M L Reyes-Díaz, M V Maestre, R M Jiménez-Rodríguez, A M García-Cabrera, J M Vázquez-Monchul, J M Díaz-Pavón, F C Padillo-Ruiz
BACKGROUND: Faecal incontinence (FI) is both a medical and social problem, with an underestimated incidence. For patients with internal anal sphincter damage, implantation of biomaterial in the anal canal is a recognised treatment option. One such material, Gatekeeper™, has previously shown promising short- and medium-term results without any major complications, including displacement. The main aim of the present study is to assess the degree to which displacement of Gatekeeper prostheses may occur and to determine whether this is associated with patient outcomes...
January 4, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28039300/pharmacological-inhibition-of-bromodomain-proteins-suppresses-retinal-inflammatory-disease-and-downregulates-retinal-th17-cells
#3
Malihe Eskandarpour, Robert Alexander, Peter Adamson, Virginia L Calder
Experimental autoimmune uveitis (EAU), in which CD4(+) Th1 and/or Th17 cells are immunopathogenic, mimics various clinical features of noninfectious uveitis in humans. The impact of bromodomain extraterminal (BET) inhibitors on Th17 cell function was studied in a mouse model of EAU in vivo and in mouse and human Th17 cells in vitro. Two BET inhibitors (GSK151 and JQ1) were able to ameliorate the progression of inflammation in EAU and in mouse CD4(+) T cells in vitro, downregulating levels of Th17 cells. Additionally, the uveitogenic capacity of Th17 cells to transfer EAU was abrogated by BET inhibitors in an adoptive transfer model...
December 30, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27964825/carbon-dioxide-laser-treatment-of-penile-intraepithelial-neoplasia
#4
Abdullah Zreik, Matthew Rewhorn, Ross Vint, Rehan Khan, David Hendry
INTRODUCTION & OBJECTIVE: The non-invasive nature of penile intraepithelial neoplasia (PeIN) allows for curative penile sparing therapy and is recommended, in their guidelines, by the European Association of Urology (EAU). Treatment options include topical chemotherapy, immunotherapy, laser treatment, photodynamic therapy and surgical excision. Our primary aim was to evaluate the outcome of carbon dioxide (CO2) laser treatment of penile intraepithelial neoplasia. METHODS: A retrospective review of 47 patients who underwent CO2 laser ablation of PeIN, from May 2008 to June 2015, in our tertiary referral centre was performed...
December 7, 2016: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/27905699/green-light-vaporization-of-the-prostate-pvp-is-it-an-adult-technique
#5
Aldo Brassetti, Cosimo De Nunzio, Nicolas Barry Delongchamps, Cristian Fiori, Francesco Porpiglia, Andrea Tubaro
INTRODUCTION: Intending to overcome Transurethral resection of the prostate (TURP) in terms of safety maintaining its efficacy profile, have led to the introduction of minimally invasive laser therapies to treat men with lower urinary tract symptoms (LUTS) secondary to Benign prostatic obstruction (BPO), each one with its unique properties. Aim of this review was to analyse and summarize all the existing data regarding the 180 W Xcelerated Performance System (XPS) Potoselective Vaporization of the Prostate (PVP)...
December 1, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27894974/ccp-score-might-improve-the-current-risk-assessment-in-newly-diagnosed-prostate-cancer-patients
#6
Marco Oderda, Gabriele Cozzi, Lorenzo Daniele, Anna Sapino, Stefania Munegato, Giuseppe Renne, Ottavio De Cobelli, Paolo Gontero
OBJECTIVE: To assess whether cell-cycle progression (CCP)-score (Prolaris) can improve the current risk assessment in newly diagnosed PCa patients. CCP-score is a well validated prognostic assay predictive of PCa death, biochemical recurrence (BCR) and progression. METHODS: We evaluated CCP-score at biopsy in 52 patients newly diagnosed with PCa who underwent radical prostatectomy. CCP-score was calculated as average RNA expression of 31 CCP genes, normalized to 15 housekeeping genes...
November 25, 2016: Urology
https://www.readbyqxmd.com/read/27886238/mc5r-and-a2ar-deficiencies-during-experimental-autoimmune-uveitis-identifies-distinct-t-cell-polarization-programs-and-a-biphasic-regulatory-response
#7
Darren J Lee, Janine Preble, Stacey Lee, C Stephen Foster, Andrew W Taylor
Autoantigen-specific regulatory immunity emerges in the spleen of mice recovering from experimental autoimmune uveitis (EAU), a murine model for human autoimmune uveoretinitis. This regulatory immunity provides induced tolerance to ocular autoantigen, and requires melanocortin 5 receptor (MC5r) expression on antigen presenting cells with adenosine 2 A receptor (A2Ar) expression on T cells. During EAU it is not well understood what roles MC5r and A2Ar have on promoting regulatory immunity. Cytokine profile analysis during EAU revealed MC5r and A2Ar each mediate distinct T cell responses, and are responsible for a functional regulatory immune response in the spleen...
November 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27874029/an-anti-tnf-%C3%AE-antibody-mimetic-to-treat-ocular-inflammation
#8
Hanieh Khalili, Richard W Lee, Peng T Khaw, Steve Brocchini, Andrew D Dick, David A Copland
Infliximab is an antibody that neutralizes TNF-α and is used principally by systemic administration to treat many inflammatory disorders. We prepared the antibody mimetic Fab-PEG-Fab (FpFinfliximab) for direct intravitreal injection to assess whether such formulations have biological activity and potential utility for ocular use. FpFinfliximab was designed to address side effects caused by antibody degradation and the presence of the Fc region. Surface plasmon resonance analysis indicated that infliximab and FpFinfliximab maintained binding affinity for both human and murine recombinant TNF-α...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27862825/competency-based-training-in-robotic-surgery-benchmark-scores-for-virtual-reality-robotic-simulation
#9
Nicholas Raison, Kamran Ahmed, Nicola Fossati, Nicolò Buffi, Alexandre Mottrie, Prokar Dasgupta, Henk Van Der Poel
OBJECTIVES: To develop benchmark scores of competency for use within a competency based virtual reality (VR) robotic training curriculum. SUBJECTS AND METHODS: This longitudinal, observational study analysed results from nine European Association of Urology hands-on-training courses in VR simulation. In all, 223 participants ranging from novice to expert robotic surgeons completed 1565 exercises. Competency was set at 75% of the mean expert score. Benchmark scores for all general performance metrics generated by the simulator were calculated...
November 10, 2016: BJU International
https://www.readbyqxmd.com/read/27860090/guideline-of-guidelines-priapism
#10
REVIEW
Asif Muneer, David Ralph
No abstract text is available yet for this article.
November 14, 2016: BJU International
https://www.readbyqxmd.com/read/27859049/lipopolysaccharide-primed-heterotolerant-dendritic-cells-suppress-experimental-autoimmune-uveoretinitis-by-multiple-mechanisms
#11
Izabela P Klaska, Elizabeth Muckersie, Cristina Martin-Granados, Maria Christofi, John V Forrester
Exposure of bone-marrow-derived dendritic cells (BMDC) to high-dose ultrapure lipopolysaccharide for 24 hr (LPS-primed BMDC) enhances their potency in preventing inter-photoreceptor retinoid binding protein: complete Freund's adjuvant-induced experimental autoimmune uveoretinitis (EAU). LPS-primed BMDC are refractory to further exposure to LPS (= endotoxin tolerance), evidenced here by decreased phosphorylation of TANK-binding kinase 1, interferon regulatory factor 3 (IRF3), c-Jun N-terminal kinase and p38 mitogen-activated protein kinase as well as impaired nuclear translocation of nuclear factor κB (NF-κB) and IRF3, resulting in reduced tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6), IL-12 and interferon-β secretion...
November 15, 2016: Immunology
https://www.readbyqxmd.com/read/27845123/re-eau-guidelines-on-the-assessment-of-non-neurogenic-male-lower-urinary-tract-symptoms-including-benign-prostatic-obstruction
#12
Steven A Kaplan
No abstract text is available yet for this article.
December 2016: Journal of Urology
https://www.readbyqxmd.com/read/27816299/early-recurrence-patterns-following-totally-intracorporeal-robot-assisted-radical-cystectomy-results-from-the-eau-robotic-urology-section-erus-scientific-working-group
#13
Justin W Collins, Abolfazl Hosseini, Christofer Adding, Tommy Nyberg, Anthony Koupparis, Edward Rowe, Matthew Perry, Rami Issa, Martin C Schumacher, Carl Wijburg, Abdullah E Canda, Melvin D Balbay, Karel Decaestecker, Christian Schwentner, Arnulf Stenzl, Sebastian Edeling, Saša Pokupić, Fredrik D'Hondt, Alexander Mottrie, Peter N Wiklund
: Recurrence following radical cystectomy often occurs early, with >80% of recurrences occurring within the first 2 yr. Debate remains as to whether robot-assisted radical cystectomy (RARC) negatively impacts early recurrence patterns because of inadequate resection or pneumoperitoneum. We report early recurrence patterns among 717 patients who underwent RARC with intracorporeal urinary diversion at nine different institutions with a minimum follow-up of 12 mo. Clinical, pathologic, radiologic, and survival data at the latest follow-up were collected...
November 2, 2016: European Urology
https://www.readbyqxmd.com/read/27784164/re-abbreviation-of-percutaneous-nephrolithotomy-pcnl-or-pnl-from-haluk-s%C3%A3-ylemez-j-endourol-30-7-830
#14
Christian Türk
No abstract text is available yet for this article.
November 29, 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27773650/is-preoperative-assessment-and-treatment-of-asymptomatic-bacteriuria-necessary-for-reducing-the-risk-of-postoperative-symptomatic-urinary-tract-infections-after-urologic-surgical-procedures
#15
Tommaso Cai, Paolo Verze, Alessandro Palmieri, Mauro Gacci, Paolo Lanzafame, Gianni Malossini, Gabriella Nesi, Gernot Bonkat, Florian M E Wagenlehner, Vincenzo Mirone, Riccardo Bartoletti, Truls E Bjerklund Johansen
OBJECTIVE: To evaluate whether it is always necessary to test for the presence of asymptomatic bacteriuria (AB) in patients undergoing urologic surgical procedures, and if present, whether to treat AB with antimicrobial prophylaxis. MATERIALS AND METHODS: All patients who underwent urologic surgical procedures from December 2008 to October 2013 in a tertiary referral urologic center were considered for this study. All patients received antimicrobial prophylaxis in line with European Association of Urology guidelines on urologic infections...
January 2017: Urology
https://www.readbyqxmd.com/read/27750248/clinical-usage-of-different-guidelines-in-routine-management-therapy-and-follow-up-of-patients-with-renal-cell-cancer-in-germany
#16
A Spek, B Szabados, B Ziegelmüller, C Stief, M D'Anastasi, M Staehler
OBJECTIVES: To evaluate the usage of different guidelines and to estimate the impact of changed recommendation in routine management, therapy and follow-up of patients with renal cell cancer (RCC). METHODS: An anonymous questionnaire was sent to 600 urologists in Germany. Twenty-seven percent of them were included in the analysis. The questions were about the practice setting, surgical and medical treatment of RCC, follow-up modalities, knowledge and usage of RCC guidelines...
October 18, 2016: Urologia Internationalis
https://www.readbyqxmd.com/read/27746283/the-role-of-the-24-hour-urine-collection-in-the-prevention-of%C3%A2-kidney-stone-recurrence
#17
Ryan S Hsi, Thomas Sanford, David S Goldfarb, Marshall L Stoller
PURPOSE: Kidney stone prevention relies on the 24-hour urine collection to diagnose metabolic abnormalities and direct dietary and pharmacological therapy. While its use is guideline supported for high risk and interested patients, evidence that the test can accurately predict recurrence or treatment response is limited. We sought to critically reassess the role of the 24-hour urine collection in stone prevention. MATERIALS AND METHODS: In addition to a MEDLINE® search to identify controlled studies of dietary and pharmacological interventions, evidence supporting the AUA (American Urological Association) and EAU (European Association of Urology) guidelines for metabolic stone prevention were evaluated...
October 13, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27734426/the-rate-of-neoadjuvant-chemotherapy-use-in-muscle-invasive-bladder-cancer-and-the-approach-of-urologists-in-turkey
#18
Oktay Üçer, Ali Can Albaz, Elif Atag, Aziz Karaoglu, Talha Muezzinoglu
PURPOSE: To investigate the proportion of neoadjuvant chemotherapy (NAC) use in patients with muscle invasive bladder cancer before radical cystectomy and the approach of urologists to this subject. MATERIALS AND METHODS: We invited 242 urologists during the 12th International Urooncology Congress in Turkey to answer a self-administered questionnaire. The questionnaire included questions related to radical cystectomy, lymph node dissection and neoadjuvant chemotherapy that had been performed in patients with muscle invasive bladder cancer by the urologist...
October 10, 2016: Urology Journal
https://www.readbyqxmd.com/read/27732978/prevalence-of-late-onset-hypogonadism-in-men-with-localized-and-metastatic-renal-cell-carcinoma
#19
Bernhard Ralla, Ahmed Magheli, Ingmar Wolff, Barbara Erber, Irena Goranova, Frank Friedersdorff, Stefan Hinz, Carsten Kempkensteffen, Kurt Miller, Jonas Busch
BACKGROUND: Cancer-related fatigue is a common symptom in patients with renal cell carcinoma (RCC) and can be similar to the fatigue found in late-onset hypogonadism (LOH). The aim of this study was to investigate the prevalence of LOH in patients with localized RCC (loRCC) and metastatic RCC (mRCC) disease under targeted therapy (TT) and compare the results to findings of epidemiologic studies. METHODS: A total of 51 mRCC patients under TT and 33 patients with loRCC undergoing nephrectomy were included...
October 13, 2016: Urologia Internationalis
https://www.readbyqxmd.com/read/27725323/-impact-in-the-quality-of-life-of-the-patients-with-double-j-catheter
#20
G Ordaz-Jurado, A Budía-Alba, P Bahilo-Mateu, J D López-Acón, M Trassierra-Villa, F Boronat-Tormo
OBJECTIVE: Double J ureteral stents are frequently used to allow free diuresis from the kidney to the bladder, but their presence has a major impact on patient's quality of life (QoL). Our aim is to describe such impact, and to describe possible solutions that can alleviate the symptoms associated with their use. METHODS: Systematic search in bibliographic sources including Cochrane library, UpToDate, Pubmed, Tripdatabase, selecting publications between 2000- 2015, and also the EAU European guidelines (2016)...
October 2016: Archivos Españoles de Urología
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