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https://www.readbyqxmd.com/read/29339653/adherence-to-the-european-association-of-urology-guidelines-a-national-survey-among-italian-urologists
#1
Giovanni Cacciamani, Walter Artibani, Alberto Briganti, James N'Dow
OBJECTIVE: The study aimed to explore adherence to the European Urological Association (EAU) Guidelines (GLs) grade A recommendation among Italian urologists. MATERIALS AND METHODS: A 13-item multiple-choice questionnaire covering oncological and non-oncological urological diseases was e-mailed to all Italian Urologist Society (Società Italiana di Urologia or SIU) members. We asked members to provide an explanation for their answer choice where needed. The quantitative data were tested using the Pearson's chi-square test...
January 16, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29336327/current-status-of-urological-training-in-europe
#2
Diego M Carrion, Juan Gómez Rivas, Francesco Esperto, Giulio Patruno, Juan L Vasquez
Modern urological training has changed drastically in the past years, due to the global surgical training trends, advances in technology, subspecialization of the field and, working hour regulations for doctors. The lack of a standardized curriculum across Europe, puts in evidence the great difference in the requirements in every country, from the start of the residency, to obtaining the accreditation. We sought to identify problems related to medical, scientific and surgical activity during urological training, and summarize data obtained from surveys realized during the European Urology Residents Education Programme (EUREP) in 2013, and from countries such as Germany, Italy and Spain...
January 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29326066/novel-everolimus-loaded-nanocarriers-for-topical-treatment-of-murine-experimental-autoimmune-uveoretinitis-eau
#3
Maren Kasper, Doris Gabriel, Michael Möller, Dirk Bauer, Lena Wildschütz, Herve Courthion, Michael R R Böhm, Martin Busch, Karin Loser, Solon Thanos, Robert Gurny, Arnd Heiligenhaus
In the present study, therapeutic effect of topically applied everolimus (EV)-loaded methoxy-poly(ethylene-glycol)-hexyl substituted poly (lactic acid) (mPEGhexPLA) nanocarriers on experimental autoimmune uveitis (EAU) were investigated. EAU was induced in B10.RIII mice via immunization with human interphotoreceptor retinoid-binding protein peptide 161-180 (hIRBPp161-180) in complete Freund's adjuvant. Everolimus-loaded mPEGhexPLA (EV/mPEGhexPLA) nanocarriers were prepared by using a solvent evaporation method...
January 8, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29313299/websites-on-bladder-cancer-an-appropriate-source-of-patient-information
#4
Johannes Salem, Pia Paffenholz, Christian Bolenz, Melanie von Brandenstein, Angelika Cebulla, Axel Haferkamp, Timur Kuru, Cheryl T Lee, David Pfister, Igor Tsaur, Hendrik Borgmann, Axel Heidenreich
A growing number of patients search for health information online. An early investigation of websites about bladder cancer (BCa) revealed mostly incomplete and particularly inaccurate information. We analyzed the quality, readability, and popularity of the most frequented websites on BCa. An Internet search on www.google.com was performed for the term "bladder cancer." After selecting the most frequented websites for patient information, HONcode quality certification, Alexa popularity rank, and readability scores (according to US grade levels) were investigated...
January 8, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29221932/evaluation-of-guidelines-for-surgical-management-of-urolithiasis
#5
Benjamin Pradère, Steeve Doizi, Silvia Proietti, Jan Brachlow, Olivier Traxer
PURPOSE: Many urological societies have provided evidence-based guidelines to help the urologist in making therapeutic choices. However, the recommendations given by these guidelines may be heterogeneous because they have been developed using a variety of methods. The objective of this study was to review key guidelines on the surgical management of urinary stones to provide practical guidance for clinical application. MATERIALS AND METHODS: Guidelines on urolithiasis from all international urological societies were searched through the society websites...
December 5, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29221587/histoire-du-thermal%C3%A3-sme-%C3%A3-av%C3%A3-ne-les-bains-et-gen%C3%A3-se-de-l%C3%A2-eau-thermale-d%C3%A2-av%C3%A3-ne-history-of-thermalism-at-av%C3%A3-ne-les-bains-and-genesis-of-the-av%C3%A3-ne-thermal-spring-water
#6
B Selas
Avene thermal spring water is recognized for more than two centuries for its benefits on skin diseases. Since 1975, the Pierre Fabre Group has modernized the facilities, and developed the brand « Eau Thermal Avène », allowing more than 2,500 patients/year to be treated by this therapeutic water. The regulation requires high standards on origin, bacteriological purity and physico-chemical stability. Many works have allowed us to understand its origin, its underground path and identify its specific physico-chemical profile...
January 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29198325/ercc1-as-a-prognostic-factor-for-survival-in-patients-with-advanced-urothelial-cancer-treated-with-platinum-based-chemotherapy-a-systematic-review-and-meta-analysis
#7
REVIEW
Yuksel Urun, Jeffrey J Leow, Andre P Fay, Laurence Albiges, Toni K Choueiri, Joaquim Bellmunt
BACKGROUND: The predictive role of excision repair cross-complementing group 1 (ERCC1) as a predictive factor in patients with advanced urothelial cancer (AUC) treated with platinum-based treatment is not well defined. Here, we evaluate the role of ERCC1 in patients with AUC treated with platinum-based treatment. METHODS: We performed comprehensive, systematic computerized search to identify relevant studies through Medline, Embase, Cochrane Controlled Trials Register (CCTR) databases and abstracts from American Society of Clinical Oncology (ASCO) and ASCO Genitourinary Cancers Symposium, European Society For Medical Oncology (ESMO) and European Association of Urology (EAU) meeting up to July 2015...
December 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29184855/dealing-with-complex-overactive-bladder-syndrome-patient-profiles-with-focus-on-fesoterodine-in-or-out-of-the-eau-guidelines
#8
REVIEW
John Heesakkers, Montserrat Espuña Pons, Philip Toozs Hobson, Emmanuel Chartier-Kastler
Overactive bladder (OAB) syndrome is a common, complex, and challenging condition. To assist the management of these patients, the European Association of Urology (EAU) updates its guidelines annually. This review reports the presentations from the symposium titled "Dealing with complex OAB patient profiles: in or out of the EAU guidelines?" held at the 32nd EAU Annual Congress in March 2017 in London. The symposium focused on three groups of OAB patients: women who may also suffer pelvic organ prolapse, stress urinary incontinence, the genitourinary syndrome of menopause (GSM); patients at risk of cognitive impairment; and elderly patients...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/29170696/speed-and-circuit-based-high-intensity-interval-training-on-recovery-oxygen-consumption
#9
Lindsay N Schleppenbach, Andreas B Ezer, Sarah A Gronemus, Katelyn R Widenski, Saori I Braun, Jeffrey M Janot
Due to the current obesity epidemic in the United States, there is growing interest in efficient, effective ways to increase energy expenditure and weight loss. Research has shown that high-intensity exercise elicits a higher Excess Post-Exercise Oxygen Consumption (EPOC) throughout the day compared to steady-state exercise. Currently, there is no single research study that examines the differences in Recovery Oxygen Consumption (ROC) resulting from high-intensity interval training (HIIT) modalities. The purpose of this study is to review the impact of circuit training (CT) and speed interval training (SIT), on ROC in both regular exercising and sedentary populations...
2017: International Journal of Exercise Science
https://www.readbyqxmd.com/read/29151111/readability-assessment-of-patient-education-material-published-by-german-speaking-associations-of-urology
#10
Patrick Betschart, Valentin Zumstein, Omar Hasan Ali, Hans-Peter Schmid, Dominik Abt
OBJECTIVE: To assess the readability and comprehensibility of web-based German-language patient education material (PEM) issued by urological associations. MATERIALS AND METHODS: German PEM available in June 2017 was obtained from the European Association of Urology (EAU), German (DGU), Swiss (SGU) and Austrian (ÖGU) Association of Urology websites. Each educational text was analyzed separately using 4 well-established readability assessment tools: the Amstad Test (AT), G-SMOG (SMOG), Wiener Sachtextformel (WS) and the Lesbarkeitsindex (LIX)...
November 18, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/29074050/discrepancy-between-european-association-of-urology-guidelines-and-daily-practice-in-the-management-of-non-muscle-invasive-bladder-cancer-results-of-a-european-survey
#11
Kees Hendricksen, Atiqullah Aziz, Perrine Bes, Felix K-H Chun, Jakub Dobruch, Luis A Kluth, Paolo Gontero, Andrea Necchi, Aidan P Noon, Bas W G van Rhijn, Michael Rink, Florian Roghmann, Morgan Rouprêt, Roland Seiler, Shahrokh F Shariat, Brian Qvick, Marek Babjuk, Evanguelos Xylinas
BACKGROUND: The European Association of Urology (EAU) non-muscle-invasive bladder cancer (NMIBC) guidelines are meant to help minimise morbidity and improve the care of patients with NMIBC. However, there may be underuse of guideline-recommended care in this potentially curable cohort. OBJECTIVE: To assess European physicians' current practice in the management of NMIBC and evaluate its concordance with the EAU 2013 guidelines. DESIGN, SETTING, AND PARTICIPANTS: Initial 45-min telephone interviews were conducted with 20 urologists to develop a 26-item questionnaire for a 30-min online quantitative interview...
October 23, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29056505/ly6c-hi-monocytes-are-required-for-mesenchymal-stem-stromal-cell-induced-immune-tolerance-in-mice-with-experimental-autoimmune-uveitis
#12
Jung Hwa Ko, Hyun Ju Lee, Hyun Jeong Jeong, Joo Youn Oh
The cells of the innate immune system, in addition to their capacity to elicit immunity, play a substantial role in immune tolerance induction. Our group has recently shown that a distinct subset of MHC II(hi)B220(hi)CD11b(mid) suppressive macrophages is increased in the lung by intravenous (IV) administration of mesenchymal stem/stromal cells (MSC) and induces immune tolerance. Herein, we demonstrate that circulating CD11b(hi)Ly6C(hi) monocytes are precursors to MHC II(hi)B220(hi)CD11b(mid) macrophages in the lung and required for MSC-induced tolerance in a mouse model of experimental autoimmune uveitis (EAU)...
December 9, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29038541/nk-cells-are-negatively-regulated-by-scd83-in-experimental-autoimmune-uveitis
#13
Wei Lin, Xuejing Man, Peng Li, Nannan Song, Yingying Yue, Bingqing Li, Yuanbin Li, Yufei Sun, Qiang Fu
Natural killer (NK) cells represent a subset of lymphocytes that contribute to innate immunity and have been reported to play a role in autoimmune uveitis. However, the mechanisms regulating NK cellular function in this condition remain unclear. Herein, we investigated the status of NK cells in experimental autoimmune uveitis (EAU). We found that the number of CD83(+)CD3(-)NK1.1(+) cells was increased in the inflamed eyes and spleens of the EAU mouse model. At the recovery stage of EAU, serum concentrations of soluble CD83 (sCD83) were increased...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28986343/treatment-of-experimental-autoimmune-uveoretinitis-with-intravitreal-injection-of-infliximab-encapsulated-in-liposomes
#14
Rui Zhang, Jiang Qian, Xiaofeng Li, Yifei Yuan
AIMS: To evaluate the safety and efficacy of intravitreal injection of liposomes encapsulating infliximab in experimental autoimmune uveoretinitis (EAU) rats. METHODS: Liposomes containing infliximab were prepared and characterised for mean particle size, entrapment efficiency, polydispersity index (PDI) and zeta potential. In vitro release profile and the stability of infliximab-lip were evaluated. EAU rats were intravitreally injected with saline, infliximab, infliximab-lip or unloaded liposomes...
October 6, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28986090/urinary-tract-infection-in-children-diagnosis-treatment-imaging-comparison-of-current-guidelines
#15
REVIEW
M Okarska-Napierała, A Wasilewska, E Kuchar
BACKGROUND AND OBJECTIVE: Urinary tract infection (UTI) is a frequent disorder of childhood, yet the proper approach for a child with UTI is still a matter of controversy. The objective of this study was to critically compare current guidelines for the diagnosis and management of UTI in children, in light of new scientific data. METHODS: An analysis was performed of the guidelines from: American Academy of Pediatrics (AAP), National Institute for Health and Care Excellence (NICE), Italian Society of Pediatric Nephrology, Canadian Paediatric Society (CPS), Polish Society of Pediatric Nephrology, and European Association of Urology (EAU)/European Society for Pediatric Urology (ESPU)...
September 19, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28958771/-ablative-therapy-in-urology-good-practice-and-perspective
#16
A Gangi, X Cathelineau, T Tricard, H Lang
INTRODUCTION: To expose the main point of discussion from present ablative therapies' guidelines and propose global perspectives. MATERIALS AND METHODS: A review of the scientific literature was performed in Medline database (http://www.ncbi.nlm.nih.gov) and Embase (http://www.embase.com/) using different associations of keywords "ablative therapy" ; "prostate cancer"; "kidney cancer"; "guidelines"; "hybrid operating room". Publications obtained were selected based on methodology, language and relevance...
September 27, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28955337/complement-component-c4-regulates-the-development-of-experimental-autoimmune-uveitis-through-a-t-cell-intrinsic-mechanism
#17
Lingjun Zhang, Brent A Bell, Yan Li, Rachel R Caspi, Feng Lin
In addition to its conventional roles in the innate immune system, complement has been found to directly regulate T cells in the adaptive immune system. Complement components, including C3, C5, and factor D, are important in regulating T cell responses. However, whether complement component C4 is involved in regulating T cell responses remains unclear. In this study, we used a T cell-dependent model of autoimmunity, experimental autoimmune uveitis (EAU) to address this issue. We compared disease severity in wild-type (WT) and C4 knockout (KO) mice using indirect ophthalmoscopy, scanning laser ophthalmoscopy, spectral-domain optical coherence tomography, and histopathological analysis...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28952703/-complications-of-contact-ureteral-lithotripsy
#18
REVIEW
E A Mamedov, V V Dutov, V V Bazaev
Shows the current real time terminology and variants of systematization and grading of complications of contact ureteral lithotripsy (CULT). Research papers related to complications of CULT published over the last three decades were analyzed. Currently there is no clear terminology, classification, systematization and grading of CULT complications. The terms used are deficient because they do not adequately characterize specific complications of CULT. For example, some researchers define a complete ureteral avulsion as a defect at two levels, but others interpret it as a defect of the ureter at only one level...
September 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28947304/comparison-of-the-eortc-tables-and-the-eau-categories-for-risk-stratification-of-patients-with-nonmuscle-invasive-bladder-cancer
#19
Malte Rieken, Shahrokh F Shariat, Luis Kluth, Joseph J Crivelli, Mohammad Abufaraj, Beat Foerster, Andrea Mari, Dafina Ilijazi, Pierre I Karakiewicz, Marek Babjuk, Mithat Gönen, Evanguelos Xylinas
PURPOSE: To characterize outcomes of patients with TaT1 urothelial carcinoma of the bladder stratified by the European Association of Urology (EAU) categories and to compare them with European Organization for Research and Treatment of Cancer (EORTC) risk groups to assess the rate and effect of reclassification. PATIENTS AND METHODS: A multi-institutional database of 5,122 patients with TaT1 urothelial carcinoma of the bladder who underwent transurethral resection of the bladder with or without adjuvant therapy at 8 institutions between 1996 and 2007...
September 22, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28940605/adjuvant-chemotherapy-after-radical-nephroureterectomy-does-not-improve-survival-in-patients-with-upper-tract-urothelial-carcinoma-a-joint-study-by-the-european-association-of-urology-young-academic-urologists-and-the%C3%A2-upper-tract-urothelial-carcinoma-collaboration
#20
Andrea Necchi, Salvatore Lo Vullo, Luigi Mariani, Marco Moschini, Kees Hendricksen, Michael Rink, Roman Sosnowski, Jakub Dobruch, Jay D Raman, Christopher G Wood, Vitaly Margulis, Morgan Roupret, Alberto Briganti, Francesco Montorsi, Evanguelos Xylinas, Shahrokh F Shariat
OBJECTIVE: To analyse the outcomes of adjuvant chemotherapy vs observation in a multicentre cohort of patients with upper tract urothelial carcinoma (UTUC) in order to clarify whether such patients benefit from adjuvant chemotherapy after radical nephroureterectomy (RNU). PATIENTS AND METHODS: Data from 15 centres were collected for a total of 1544 patients, treated between 2000 and 2015. Criteria for patient selection included pT2-4N0/x stage, or lymph node-positive disease, and prior RNU...
September 20, 2017: BJU International
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