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https://www.readbyqxmd.com/read/29151111/readability-assessment-of-patient-education-material-published-by-german-speaking-associations-of-urology
#1
Patrick Betschart, Valentin Zumstein, Omar Hasan Ali, Hans-Peter Schmid, Dominik Abt
OBJECTIVE: To assess the readability and comprehensibility of web-based German-language patient education material (PEM) issued by urological associations. MATERIALS AND METHODS: German PEM available in June 2017 was obtained from the European Association of Urology (EAU), German (DGU), Swiss (SGU) and Austrian (ÖGU) Association of Urology websites. Each educational text was analyzed separately using 4 well-established readability assessment tools: the Amstad Test (AT), G-SMOG (SMOG), Wiener Sachtextformel (WS) and the Lesbarkeitsindex (LIX)...
November 18, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/29074050/discrepancy-between-european-association-of-urology-guidelines-and-daily-practice-in-the-management-of-non-muscle-invasive-bladder-cancer-results-of-a-european-survey
#2
Kees Hendricksen, Atiqullah Aziz, Perrine Bes, Felix K-H Chun, Jakub Dobruch, Luis A Kluth, Paolo Gontero, Andrea Necchi, Aidan P Noon, Bas W G van Rhijn, Michael Rink, Florian Roghmann, Morgan Rouprêt, Roland Seiler, Shahrokh F Shariat, Brian Qvick, Marek Babjuk, Evanguelos Xylinas
BACKGROUND: The European Association of Urology (EAU) non-muscle-invasive bladder cancer (NMIBC) guidelines are meant to help minimise morbidity and improve the care of patients with NMIBC. However, there may be underuse of guideline-recommended care in this potentially curable cohort. OBJECTIVE: To assess European physicians' current practice in the management of NMIBC and evaluate its concordance with the EAU 2013 guidelines. DESIGN, SETTING, AND PARTICIPANTS: Initial 45-min telephone interviews were conducted with 20 urologists to develop a 26-item questionnaire for a 30-min online quantitative interview...
October 23, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29056505/ly6c-hi-monocytes-are-required-for-mesenchymal-stem-stromal-cell-induced-immune-tolerance-in-mice-with-experimental-autoimmune-uveitis
#3
Jung Hwa Ko, Hyun Ju Lee, Hyun Jeong Jeong, Joo Youn Oh
The cells of the innate immune system, in addition to their capacity to elicit immunity, play a substantial role in immune tolerance induction. Our group has recently shown that a distinct subset of MHC II(hi)B220(hi)CD11b(mid) suppressive macrophages is increased in the lung by intravenous (IV) administration of mesenchymal stem/stromal cells (MSC) and induces immune tolerance. Herein, we demonstrate that circulating CD11b(hi)Ly6C(hi) monocytes are precursors to MHC II(hi)B220(hi)CD11b(mid) macrophages in the lung and required for MSC-induced tolerance in a mouse model of experimental autoimmune uveitis (EAU)...
December 9, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29038541/nk-cells-are-negatively-regulated-by-scd83-in-experimental-autoimmune-uveitis
#4
Wei Lin, Xuejing Man, Peng Li, Nannan Song, Yingying Yue, Bingqing Li, Yuanbin Li, Yufei Sun, Qiang Fu
Natural killer (NK) cells represent a subset of lymphocytes that contribute to innate immunity and have been reported to play a role in autoimmune uveitis. However, the mechanisms regulating NK cellular function in this condition remain unclear. Herein, we investigated the status of NK cells in experimental autoimmune uveitis (EAU). We found that the number of CD83(+)CD3(-)NK1.1(+) cells was increased in the inflamed eyes and spleens of the EAU mouse model. At the recovery stage of EAU, serum concentrations of soluble CD83 (sCD83) were increased...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28986343/treatment-of-experimental-autoimmune-uveoretinitis-with-intravitreal-injection-of-infliximab-encapsulated-in-liposomes
#5
Rui Zhang, Jiang Qian, Xiaofeng Li, Yifei Yuan
AIMS: To evaluate the safety and efficacy of intravitreal injection of liposomes encapsulating infliximab in experimental autoimmune uveoretinitis (EAU) rats. METHODS: Liposomes containing infliximab were prepared and characterised for mean particle size, entrapment efficiency, polydispersity index (PDI) and zeta potential. In vitro release profile and the stability of infliximab-lip were evaluated. EAU rats were intravitreally injected with saline, infliximab, infliximab-lip or unloaded liposomes...
October 6, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28986090/urinary-tract-infection-in-children-diagnosis-treatment-imaging-comparison-of-current-guidelines
#6
REVIEW
M Okarska-Napierała, A Wasilewska, E Kuchar
BACKGROUND AND OBJECTIVE: Urinary tract infection (UTI) is a frequent disorder of childhood, yet the proper approach for a child with UTI is still a matter of controversy. The objective of this study was to critically compare current guidelines for the diagnosis and management of UTI in children, in light of new scientific data. METHODS: An analysis was performed of the guidelines from: American Academy of Pediatrics (AAP), National Institute for Health and Care Excellence (NICE), Italian Society of Pediatric Nephrology, Canadian Paediatric Society (CPS), Polish Society of Pediatric Nephrology, and European Association of Urology (EAU)/European Society for Pediatric Urology (ESPU)...
September 19, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28958771/-ablative-therapy-in-urology-good-practice-and-perspective
#7
A Gangi, X Cathelineau, T Tricard, H Lang
INTRODUCTION: To expose the main point of discussion from present ablative therapies' guidelines and propose global perspectives. MATERIALS AND METHODS: A review of the scientific literature was performed in Medline database (http://www.ncbi.nlm.nih.gov) and Embase (http://www.embase.com/) using different associations of keywords "ablative therapy" ; "prostate cancer"; "kidney cancer"; "guidelines"; "hybrid operating room". Publications obtained were selected based on methodology, language and relevance...
September 27, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28955337/complement-component-c4-regulates-the-development-of-experimental-autoimmune-uveitis-through-a-t-cell-intrinsic-mechanism
#8
Lingjun Zhang, Brent A Bell, Yan Li, Rachel R Caspi, Feng Lin
In addition to its conventional roles in the innate immune system, complement has been found to directly regulate T cells in the adaptive immune system. Complement components, including C3, C5, and factor D, are important in regulating T cell responses. However, whether complement component C4 is involved in regulating T cell responses remains unclear. In this study, we used a T cell-dependent model of autoimmunity, experimental autoimmune uveitis (EAU) to address this issue. We compared disease severity in wild-type (WT) and C4 knockout (KO) mice using indirect ophthalmoscopy, scanning laser ophthalmoscopy, spectral-domain optical coherence tomography, and histopathological analysis...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28952703/-complications-of-contact-ureteral-lithotripsy
#9
REVIEW
E A Mamedov, V V Dutov, V V Bazaev
Shows the current real time terminology and variants of systematization and grading of complications of contact ureteral lithotripsy (CULT). Research papers related to complications of CULT published over the last three decades were analyzed. Currently there is no clear terminology, classification, systematization and grading of CULT complications. The terms used are deficient because they do not adequately characterize specific complications of CULT. For example, some researchers define a complete ureteral avulsion as a defect at two levels, but others interpret it as a defect of the ureter at only one level...
September 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28947304/comparison-of-the-eortc-tables-and-the-eau-categories-for-risk-stratification-of-patients-with-nonmuscle-invasive-bladder-cancer
#10
Malte Rieken, Shahrokh F Shariat, Luis Kluth, Joseph J Crivelli, Mohammad Abufaraj, Beat Foerster, Andrea Mari, Dafina Ilijazi, Pierre I Karakiewicz, Marek Babjuk, Mithat Gönen, Evanguelos Xylinas
PURPOSE: To characterize outcomes of patients with TaT1 urothelial carcinoma of the bladder stratified by the European Association of Urology (EAU) categories and to compare them with European Organization for Research and Treatment of Cancer (EORTC) risk groups to assess the rate and effect of reclassification. PATIENTS AND METHODS: A multi-institutional database of 5,122 patients with TaT1 urothelial carcinoma of the bladder who underwent transurethral resection of the bladder with or without adjuvant therapy at 8 institutions between 1996 and 2007...
September 22, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28940605/adjuvant-chemotherapy-after-radical-nephroureterectomy-does-not-improve-survival-in-patients-with-upper-tract-urothelial-carcinoma-a-joint-study-by-the-european-association-of-urology-young-academic-urologists-and-the%C3%A2-upper-tract-urothelial-carcinoma-collaboration
#11
Andrea Necchi, Salvatore Lo Vullo, Luigi Mariani, Marco Moschini, Kees Hendricksen, Michael Rink, Roman Sosnowski, Jakub Dobruch, Jay D Raman, Christopher G Wood, Vitaly Margulis, Morgan Roupret, Alberto Briganti, Francesco Montorsi, Evanguelos Xylinas, Shahrokh F Shariat
OBJECTIVE: To analyse the outcomes of adjuvant chemotherapy vs observation in a multicentre cohort of patients with upper tract urothelial carcinoma (UTUC) in order to clarify whether such patients benefit from adjuvant chemotherapy after radical nephroureterectomy (RNU). PATIENTS AND METHODS: Data from 15 centres were collected for a total of 1544 patients, treated between 2000 and 2015. Criteria for patient selection included pT2-4N0/x stage, or lymph node-positive disease, and prior RNU...
September 20, 2017: BJU International
https://www.readbyqxmd.com/read/28934212/outcome-of-papillary-versus-clear-cell-renal-cell-carcinoma-varies-significantly-in-non-metastatic-disease
#12
MULTICENTER STUDY
Nina Wagener, Dominic Edelmann, Axel Benner, Richard Zigeuner, Hendrik Borgmann, Ingmar Wolff, Laura M Krabbe, Mireia Musquera, Paolo Dell'Oglio, Umberto Capitanio, Tobias Klatte, Luca Cindolo, Matthias May, Sabine D Brookman-May
Renal cell carcinoma (RCC) comprises a heterogenous group of tumors. Traditionally, papillary RCC (pRCC) is associated with a favorable outcome compared to clear cell RCC (ccRCC), while other series report equivalent or worse prognosis. In this paper we comparatively evaluate outcome of pRCC versus ccRCC in two large multi-institutional databases (cohort study), including distribution of pRCC subtypes 1 and 2. Retrospective data of 1,943 surgically treated pRCC patients from 17 European/ North American centers between 1984-2015 were compared to 5,600 ccRCC patients from a database comprising 11 European/ North American centers (1984-2011)...
2017: PloS One
https://www.readbyqxmd.com/read/28927062/anticancer-activity-and-antioxidant-potential-of-aponogeton-undulatus-against-ehrlich-ascites-carcinoma-cells-in-swiss-albino-mice
#13
Mohammad Saifur Rahman, Mohammad Badrul Alam, Yun Hee Choi, Jin Cheol Yoo
The in vivo anticancer and in vitro antioxidant effects of the crude methanol extract of Aponogeton undulatus, in addition to its various organic fractions, were investigated. Various assay methods, including the total antioxidant capacity assay, lipid peroxidation inhibition assay, 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay and ferrous reducing power assessment were used to evaluate the antioxidant potential of the crude extract and its organic fractions. The ethyl acetate fraction (EAU) demonstrated the highest antioxidant capacity (175...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28924192/short-chain-fatty-acids-ameliorate-immune-mediated-uveitis-partially-by-altering-migration-of-lymphocytes-from-the-intestine
#14
Yukiko K Nakamura, Cathleen Janowitz, Christina Metea, Mark Asquith, Lisa Karstens, James T Rosenbaum, Phoebe Lin
Short chain fatty acids (SCFA) are metabolites of intestinal bacteria resulting from fermentation of dietary fiber. SCFA are protective in various animal models of inflammatory disease. We investigated the effects of exogenous administration of SFCAs, particularly propionate, on uveitis using an inducible model of experimental autoimmune uveitis (EAU). Oral SCFA administration attenuated uveitis severity in a mouse strain-dependent manner through regulatory T cell induction among lymphocytes in the intestinal lamina propria (LPL) and cervical lymph nodes (CLN)...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28922100/frequency-and-antibiotic-resistance-of-bacteria-implicated-in-community-urinary-tract-infections-in-north-aveiro-between-2011-and-2014
#15
Tânia Costa, Inês Linhares, Ricardo Ferreira, Jasmin Neves, Adelaide Almeida
AIMS: The present study aims to evaluate the predominance of uropathogens responsible for urinary tract infection (UTI) and determine their resistance patterns, to assess if the recommended empirical treatment is appropriate for the studied population. Samples were collected in Aveiro (Portugal) from an ambulatory service between June 2011 and June 2014. RESULTS: From the 4,270 positive urine samples for UTI, 3,561 (83%) were from women and only 709 (17%) were from men...
September 18, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28917594/key-steps-in-conducting-systematic-reviews-for-underpinning-clinical-practice-guidelines-methodology-of-the-european-association-of-urology
#16
Thomas Knoll, Muhammad Imran Omar, Steven Maclennan, Virginia Hernández, Steven Canfield, Yuhong Yuan, Max Bruins, Lorenzo Marconi, Hein Van Poppel, James N'Dow, Richard Sylvester
CONTEXT: The findings of systematic reviews (SRs) and meta-analyses (MAs) are used for clinical decision making. The European Association of Urology has committed increasing resources into the development of high quality clinical guidelines based on such SRs and MAs. OBJECTIVE: In this paper, we have summarised the process of conducting SRs for underpinning clinical practice guidelines under the auspices of the European Association of Urology Guidelines Office. EVIDENCE ACQUISITION: The process involves explicit methods and the findings should be reproducible...
September 13, 2017: European Urology
https://www.readbyqxmd.com/read/28914568/human-embryonic-stem-cell-derived-mesenchymal-stromal-cells-decrease-the-development-of-severe-experimental-autoimmune-uveitis-in-b10-riii-mice
#17
Yu Qin, Ann M Chan, Yu-Ling Chang, Anna Matynia, Nicholas A Kouris, Erin A Kimbrel, Negin Ashki, Sachin Parikh, Michael B Gorin, Robert Lanza, Ralph D Levinson, Lynn K Gordon
PURPOSE: We investigated the effect of exogenously administered human embryonic stem cell-derived mesenchymal stromal cells (hESC-MSCs) in experimental autoimmune uveitis (EAU) in B10.RIII mice, a murine model of severe uveitis. METHODS: B10.RIII mice were immunized with an uveitogenic peptide, and intraperitoneal injections of 5 million hESC-MSCs per animal were given on the same day. Behavioral light sensitivity assays, histological evaluation, cytokine production, and regulatory T cells were analyzed at the peak of the disease...
September 15, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28905177/readability-assessment-of-online-patient-education-materials-provided-by-the-european-association-of-urology
#18
Patrick Betschart, Valentin Zumstein, Maico Bentivoglio, Daniel Engeler, Hans-Peter Schmid, Dominik Abt
PURPOSE: To assess the readability of the web-based patient education material provided by the European Association of Urology. MATERIALS AND METHODS: English patient education materials (PEM) as available in May 2017 were obtained from the EAU website. Each topic was analyzed separately using six well-established readability assessment tools, including Flesch-Kincaid Grade Level (FKGL), SMOG Grade Level (SMOG), Coleman-Liau Index (CLI), Gunning Fog Index (GFI), Flesch Reading Ease Formula (FRE) and Fry Readability Graph (FRG)...
December 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28882031/a-multiregional-italian-cohort-of-24-hour-urine-metabolic-evaluation-in-renal-stone-formers
#19
Francesco Esperto, Martino Marangella, Alberto Trinchieri, Michele Petrarulo, Roberto Miano
BACKGROUND: Nephrolithiasis is a common condition with several studies documenting an increased prevalence over the past four decades. EAU and AUA guidelines recommend 24-hour urine metabolic evaluation in high-risk stone formers. Aim of this study is to retrospectively evaluate the first three years of experience with Lithotest® (Biohealth Italia Srl, Turin, Italy) through the analysis of demographic, clinical and biochemical data collected from a large cohort of patients with kidney stones...
September 7, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28867446/european-association-of-urology-guidelines-on-upper-urinary-tract-urothelial-carcinoma-2017-update
#20
Morgan Rouprêt, Marko Babjuk, Eva Compérat, Richard Zigeuner, Richard J Sylvester, Maximilian Burger, Nigel C Cowan, Paolo Gontero, Bas W G Van Rhijn, A Hugh Mostafid, Joan Palou, Shahrokh F Shariat
CONTEXT: The European Association of Urology (EAU) Guidelines Panel on Upper Urinary Tract Urothelial Carcinoma (UTUC) has prepared updated guidelines to aid clinicians in the current evidence-based management of UTUC and to incorporate recommendations into clinical practice. OBJECTIVE: To provide an overview of the EAU guidelines on UTUC as an aid to clinicians. EVIDENCE ACQUISITION: The recommendations provided in the current guidelines are based on a thorough review of available UTUC guidelines and articles identified following a systematic search of Medline...
September 1, 2017: European Urology
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