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https://www.readbyqxmd.com/read/28454147/layout-of-nalm-fiber-laser-with-adjustable-peak-power-of-generated-pulses
#1
Sergey Smirnov, Sergey Kobtsev, Alexey Ivanenko, Alexey Kokhanovskiy, Anna Kemmer, Mikhail Gervaziev
The Letter proposes a new layout of a passively mode-locked fiber laser based on a nonlinear amplifying loop mirror (NALM) with two stretches of active fiber and two independently controlled pump modules. In contrast with conventional NALM configurations using a single piece of active fiber that yields virtually constant peak power, the proposed novel laser features larger than a factor of 2 adjustment range of peak power of generated pulses. The proposed layout also provides independent adjustment of duration and peak power of generated pulses as well as power-independent control of generated pulse spectral width impossible in NALM lasers with a single piece of active fiber...
May 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28454134/self-stabilization-of-an-optical-frequency-comb-using-a-short-path-length-interferometer
#2
James P Cahill, Weimin Zhou, Curtis R Menyuk
We stabilized the repetition rate of an optical frequency comb using a self-referenced phase-locked loop. The phase-locked loop generated its error signal with a fiber-optic delay-line interferometer that had a path-length difference of 8 m. We used the stabilized repetition rate to generate a 10 GHz signal with a single-sideband phase noise that was limited by environmental noise to -120  dBc/Hz at an offset frequency of 1 kHz. Modeling results indicate that thermoconductive noise sets a fundamental phase noise limit for an 8 m interferometer of -152  dBc/Hz at a 1 kHz offset frequency...
May 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28454119/anti-proliferative-and-anti-secretory-effects-of-everolimus-on-human-pancreatic-neuroendocrine-tumors-primary-cultures-is-there-any-benefit-from-combination-with-somatostatin-analogs
#3
Amira Mohamed, David Romano, Alexandru Saveanu, Catherine Roche, Manuela Albertelli, Federica Barbieri, Thierry Brue, Patricia Niccoli, Jean-Robert Delpero, Stephane Garcia, Diego Ferone, Tullio Florio, Vincent Moutardier, Flora Poizat, Anne Barlier, Corinne Gerard
Therapeutic management of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) is challenging. The mammalian target of rapamycin (mTOR) inhibitor everolimus recently obtained approval from the Food and Drug Administration for the treatment of patients with advanced pancreatic neuroendocrine tumors (pNETs). Despite its promising antitumor efficacy observed in cell lines, clinical benefit for patients is unsatisfactory. The limited therapeutic potential of everolimus in cancer cells has been attributed to Akt activation due to feedback loops relief following mTOR inhibition...
April 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454068/biochar-based-water-treatment-systems-as-a-potential-low-cost-and-sustainable-technology-for-clean-water-provision
#4
REVIEW
Willis Gwenzi, Nhamo Chaukura, Chicgoua Noubactep, Fungai N D Mukome
Approximately 600 million people lack access to safe drinking water, hence achieving Sustainable Development Goal 6 (Ensure availability and sustainable management of water and sanitation for all by 2030) calls for rapid translation of recent research into practical and frugal solutions within the remaining 13 years. Biochars, with excellent capacity to remove several contaminants from aqueous solutions, constitute an untapped technology for drinking water treatment. Biochar water treatment has several potential merits compared to existing low-cost methods (i...
April 25, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28454042/cortical-plasticity-and-levodopa-induced-dyskinesias-in-parkinson-s-disease-connecting-the-dots-in-a-multicomponent-network
#5
REVIEW
Roopa Rajan, Traian Popa, Angelo Quartarone, Maria Felice Ghilardi, Asha Kishore
Levodopa-induced dyskinesias are motor complications following long term dopaminergic therapy in Parkinson's disease (PD). Impaired brain plasticity resulting in the creation of aberrant motor maps intended to encode normal voluntary movement is proposed to result in the development of dyskinesias. Traditionally, the various nodes in the motor network like the striato-cortical and the cerebello-thalamic loops were thought to function independent of each other with little communication among them. Anatomical evidence from primates revealed the existence of reciprocal loops between the basal ganglia and the cerebellum providing an anatomical basis for communication between the motor network loops...
April 10, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28453855/newly-characterized-interaction-stabilizes-dna-structure-oligoethylene-glycols-stabilize-g-quadruplexes-ch-%C3%AF-interactions
#6
Hisae Tateishi-Karimata, Tatsuya Ohyama, Takahiro Muraoka, Peter Podbevsek, Adam M Wawro, Shigenori Tanaka, Shu-Ichi Nakano, Kazushi Kinbara, Janez Plavec, Naoki Sugimoto
Oligoethylene glycols are used as crowding agents in experiments that aim to understand the effects of intracellular environments on DNAs. Moreover, DNAs with covalently attached oligoethylene glycols are used as cargo carriers for drug delivery systems. To investigate how oligoethylene glycols interact with DNAs, we incorporated deoxythymidine modified with oligoethylene glycols of different lengths, such as tetraethylene glycol (TEG), into DNAs that form antiparallel G-quadruplex or hairpin structures such that the modified residues were incorporated into loop regions...
April 27, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28453681/sphinx-merging-knowledge-based-and-ab-initio-approaches-to-improve-protein-loop-prediction
#7
Claire Marks, Jaroslaw Nowak, Stefan Klostermann, Guy Georges, James Dunbar, Jiye Shi, Sebastian Kelm, Charlotte M Deane
Motivation: Loops are often vital for protein function, however, their irregular structures make them difficult to model accurately. Current loop modelling algorithms can mostly be divided into two categories: knowledge-based, where databases of fragments are searched to find suitable conformations and ab initio, where conformations are generated computationally. Existing knowledge-based methods only use fragments that are the same length as the target, even though loops of slightly different lengths may adopt similar conformations...
May 1, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28453552/specific-blockade-of-rictor-mtor-association-inhibits-mtorc2-activity-and-is-cytotoxic-in-glioblastoma
#8
Angelica Benavides-Serrato, Jihye Lee, Brent Holmes, Kenna A Landon, Tariq Bashir, Michael E Jung, Alan Lichtenstein, Joseph Gera
A small molecule which specifically blocks the interaction of Rictor and mTOR was identified utilizing a high-throughput yeast two-hybrid screen and evaluated as a potential inhibitor of mTORC2 activity in glioblastoma multiforme (GBM). In vitro, CID613034 inhibited mTORC2 kinase activity at submicromolar concentrations and in cellular assays specifically inhibited phosphorylation of mTORC2 substrates, including AKT (Ser-473), NDRG1 (Thr-346) and PKCα (Ser-657), while having no appreciable effects on the phosphorylation status of the mTORC1 substrate S6K (Thr-389) or mTORC1-dependent negative feedback loops...
2017: PloS One
https://www.readbyqxmd.com/read/28453549/idiosyncratic-recognition-of-uug-uua-codons-by-modified-nucleoside-5-taurinomethyluridine-%C3%AF-m5u-present-at-wobble-position-in-anticodon-loop-of-trnaleu-a-molecular-modeling-approach
#9
Asmita S Kamble, Prayagraj M Fandilolu, Susmit B Sambhare, Kailas D Sonawane
Lack of naturally occurring modified nucleoside 5-taurinomethyluridine (τm5U) at the 'wobble' 34th position in tRNALeu causes mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). The τm5U34 specifically recognizes UUG and UUA codons. Structural consequences of τm5U34 to read cognate codons have not been studied so far in detail at the atomic level. Hence, 50ns multiple molecular dynamics (MD) simulations of various anticodon stem loop (ASL) models of tRNALeu in presence and absence of τm5U34 along with UUG and UUA codons were performed to explore the dynamic behaviour of τm5U34 during codon recognition process...
2017: PloS One
https://www.readbyqxmd.com/read/28453548/self-feedbacks-determine-the-sustainability-of-human-interventions-in-eco-social-complex-systems-impacts-on-biodiversity-and-ecosystem-health
#10
Marco Ortiz, Richard Levins
Several administrative polices have been implemented in order to reduce the negative impacts of fishing on natural ecosystems. Four eco-social models with different levels of complexity were constructed, which represent the seaweed harvest in central-northern Chile under two different regimes, Management and Exploitation Areas for Benthic Resources (MAEBRs) and Open Access Areas (OAAs). The dynamics of both regimes were analyzed using the following theoretical frameworks: (1) Loop Analysis, which allows the local stability or sustainability of the models and scenarios to be assessed; and (2) Hessian´s optimization procedure of a global fishery function (GFF) that represents each dynamics of each harvest...
2017: PloS One
https://www.readbyqxmd.com/read/28453390/the-torments-of-the-cohesin-ring
#11
Alap P Chavda, Keven Ang, Dmitri Ivanov
Cohesin is a ring-shaped protein complex which comprises the Smc1, Smc3 and Scc1 subunits. It topologically embraces chromosomal DNA to connect sister chromatids and stabilize chromatin loops. It is required for proper chromosomal segregation, DNA repair and transcriptional regulation. We have recently reported that cohesin rings can adopt a "collapsed" rod-like conformation which is driven by the interaction between the Smc1 and Smc3 coiled coil arms and is regulated by post-translational modifications. The "collapsed" conformation plays a role in cohesin ring assembly and its loading on the DNA...
February 27, 2017: Nucleus
https://www.readbyqxmd.com/read/28449310/rational-design-of-nanobody80-loop-peptidomimetics-towards-biased-%C3%AE-2-adrenergic-receptor-ligands
#12
Charlotte Martin, Samuel Moors, Mia Danielsen, Cecilia Betti, Cecilia Fabris, Daniel Sejer Pedersen, Els Pardon, Marion Peyressatre, Krisztina Fehér, Jose C Martins, Jesper Mosolff Mathiesen, May Morris, Nick Devoogdt, Vicky Caveliers, Frank De Proft, Jan Steyaert, Steven Ballet
G protein-coupled receptors (GPCRs) play an important role for many cellular responses, and as such their mechanism of action is of utmost interest. To gain insight into the active conformation of GPCRs, the X-ray crystal structures of Nanobody(Nb)-stabilized β2-adrenergic receptor (β2AR) have been reported. Nb80 in particular is able to bind the intracellular G protein binding site of β2AR and stabilize the receptors in an active conformation. Within Nb80, the complementarity-determining region 3 (CDR3) is responsible for most of the binding interactions...
April 27, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28449044/vernakalant-does-not-alter-early-repolarization-or-contractility-in-normal-and-electrically-remodelled-atria
#13
Arne van Hunnik, Hussein Nasrallah, Dennis H Lau, Marion Kuiper, Sander Verheule, Ulrich Schotten
Aims: Besides the inhibition of the sodium inward current, vernakalant also inhibits the ultra rapid rectifier (IKur) and transient outward current (Ito). Inhibition of these currents increases contractility in canine atrial myocytes and goat atria. We investigated the effect of vernakalant on early repolarization and contractility in normal and electrically remodelled atria. Methods and results: Goats were implanted a pressure catheter, piezoelectric crystals, and electrodes to obtain atrial contractility and effective refractory period (ERP)...
April 25, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28448853/a-cluster-of-aspartic-residues-in-the-extracellular-loop-ii-of-par-4-is-important-for-thrombin-interaction-and-activation-of-platelets
#14
Daniel Sánchez Centellas, Sushanth Gudlur, Alejandro Vicente-Carrillo, Sofia Ramström, Tomas L Lindahl
Thrombin activates platelets via proteolytic cleavage of protease-activated receptors (PARs) 1 and 4. The two PARs have distinct but complementary roles. The mechanisms responsible for PAR1 activation by thrombin have been extensively studied. However, much less is known regarding thrombin activation of PAR4, especially the potential involvement of regions of PAR4 other than the N-terminal, which is bound to the catalytic site of thrombin. We have studied PAR4 in S. cerevisiae strain MMY12, an expression system in which the GPCR receptors are connected to a Lac Z reporter gene resulting in increased β-galactosidase activity...
April 13, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28448579/il-33-receptor-st2-regulates-the-cognitive-impairments-associated-with-experimental-cerebral-malaria
#15
Flora Reverchon, Stéphane Mortaud, Maëliss Sivoyon, Isabelle Maillet, Anthony Laugeray, Jennifer Palomo, Céline Montécot, Améziane Herzine, Sandra Meme, William Meme, François Erard, Bernhard Ryffel, Arnaud Menuet, Valérie F J Quesniaux
Cerebral malaria (CM) is associated with a high mortality rate and long-term neurocognitive impairment in survivors. The murine model of experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA (PbA)-infection reproduces several of these features. We reported recently increased levels of IL-33 protein in brain undergoing ECM and the involvement of IL-33/ST2 pathway in ECM development. Here we show that PbA-infection induced early short term and spatial memory defects, prior to blood brain barrier (BBB) disruption, in wild-type mice, while ST2-deficient mice did not develop cognitive defects...
April 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28448574/fusion-expression-of-occludin-extracellular-loops-and-an-%C3%AE-helical-bundle-a-new-research-model-for-tight-junction
#16
Xiaojing Chi, Xia Zhao, Wei Wang, Yuqiang Niu, Min Cheng, Xiuying Liu, Sheng Cui, Wei Yang
Tight junctions (TJs) are the outermost structures of intercellular junctions and are highly specialized membrane domains involved in many important cellular processes. However, most TJ proteins are four-time transmembrane proteins and are difficult to express in their correct soluble form, which limits their functional study and therapeutic application. Human occludin (OCLN) is a major component of TJs and an essential co-receptor for hepatitis C virus (HCV) cell entry. To explore expression strategy for recombinant TJ proteins possessing integrated and functional extracellular loops, OCLN was here used as a model molecule, and several prokaryotic fusion constructs were designed by docking OCLN extracellular loops (ECLs) to HIV-1 gp41 NHR and CHR six-helical bundle (6HV1); then their biophysical features and anti-HCV activity were evaluated...
2017: PloS One
https://www.readbyqxmd.com/read/28448138/idp-specific-force-field-ff14idpsff-improves-the-conformer-sampling-of-intrinsically-disordered-proteins
#17
Dong Song, Ray Luo, Hai-Feng Chen
Intrinsically disordered proteins (IDPs) or intrinsically disordered regions have not fixed tertiary structure, but play key roles in signal regulation, molecule recognition, and drug target. However it is difficult to study the structure and function of IDPs by traditional experimental methods because of their diverse conformations. Limitations of current generic protein force fields and solvent models were reported in the previous simulations of IDPs. We have also explored to overcome these limitations by developing ff99IDPs and ff14IDPs force fields to correct the dihedral distribution for eight disordered promoting residues often observed in IDPs and found encouraging improvements...
April 27, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28448029/gain-compensation-methodology-for-a-sinusoidal-scan-of-a-galvanometer-mirror-in-proportional-integral-differential-control-using-pre-emphasis-techniques
#18
Tomohiko Hayakawa, Takanoshin Watanabe, Taku Senoo, Masatoshi Ishikawa
Galvanometer mirrors are used for optical applications such as target tracking, drawing, and scanning control because of their high speed and accuracy. However, the responsiveness of a galvanometer mirror is limited by its inertia; hence, the gain of a galvanometer mirror is reduced when the control path is steep. In this research, we propose a method to extend the corresponding frequency using a pre-emphasis technique to compensate for the gain reduction of galvanometer mirrors in sine-wave path tracking using proportional-integral-differential (PID) control...
April 4, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28447851/-understanding-the-role-of-speech-production-in-reading-evidence-for-a-print-to-speech-neural-network-using-graphical-analysis-correction-to-cummine-et-al-2016
#19
(no author information available yet)
Reports an error in "Understanding the role of speech production in reading: Evidence for a print-to-speech neural network using graphical analysis" by Jacqueline Cummine, Ivor Cribben, Connie Luu, Esther Kim, Reyhaneh Bahktiari, George Georgiou and Carol A. Boliek (Neuropsychology, 2016[May], Vol 30[4], 385-397). In the article, the fifth author's name [Bakhtiari] was misspelled. The online version of this article has been corrected. (The following abstract of the original article appeared in record 2015-49069-001...
May 2017: Neuropsychology
https://www.readbyqxmd.com/read/28447844/frontal-theta-band-oscillations-predict-error-correction-and-posterror-slowing-in-typing
#20
Çığır Kalfaoğlu, Tom Stafford, Elizabeth Milne
Performance errors are associated with robust behavioral and electroencephalography (EEG) effects. However, there is a debate about the nature of the relationship between these effects and implicit versus explicit error awareness. Our aim was to study the relationship between error related electrophysiological effects, such as spectral perturbations in fronto-medial theta band oscillations (FMT), and error awareness in typing. Typing has an advantage as an experimental paradigm in that detected errors are quickly and habitually signaled by the participant using backspace, allowing separation of detected from undetected errors without interruption in behavior...
April 27, 2017: Journal of Experimental Psychology. Human Perception and Performance
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