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https://www.readbyqxmd.com/read/28738523/a-natriuretic-peptides-clearance-receptor-s-agonist-reduces-pulmonary-artery-pressures-and-enhances-cardiac-performance-in-preclinical-models-new-hope-for-patients-with-pulmonary-hypertension-due-to-left-ventricular-heart-failure
#1
Emmanuel Eroume Egom, Tiam Feridooni, Rebabonye B Pharithi, Barkat Khan, Haaris A Shiwani, Vincent Maher, Yassine El Hiani, Kishore B S Pasumarthi, Hilaire A Ribama
BACKGROUND: In patients with left ventricular heart failure (HF), the development of pulmonary hypertension (PH) is common and represents a strong predictor of death. Despite recent advances in the pathophysiological understanding there is as yet no prospect of cure of this deadly clinical entity and the majority of patients continue to progress to right ventricular failure and die. Furthermore, there is no single medical treatment currently approved for PH related to HF. There is, therefore an urgent unmet need to identify novel pharmacological agents that will prevent the progressive increased or reverse the elevated pulmonary arterial pressures while enhancing cardiac performance in HF...
July 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28738446/single-stage-versus-two-stage-arteriovenous-loop-microsurgical-reconstruction-a-meta-analysis-of-the-literature
#2
REVIEW
Rebecca Knackstedt, Rachel Aliotta, James Gatherwright, Risal Djohan, Brian Gastman, Graham Schwarz, Mark Hendrickson, Raffi Gurunluoglu
BACKGROUND: Arteriovenous (AV) loops can be utilized in a single- or two-stage approach in free flap reconstruction when proper vessels are not available. However, there exists no consensus on which method leads to superior microsurgical and patient outcomes. The purpose of this article was to review single- versus two-stage AV loops utilized in free flap reconstruction with a focus on complications and overall outcomes. METHODS: A systematic review of AV loops for autologous free tissue transfer was conducted...
July 24, 2017: Microsurgery
https://www.readbyqxmd.com/read/28738239/delayed-graft-duodenal-perforation-due-to-impacted-food-five-years-after-simultaneous-pancreas-kidney-transplantation-a-case-report
#3
Taizo Sakata, Hideki Katagiri, Tadao Kubota, Takashi Sakamoto, Kentaro Yoshikawa, Alan Kawarai Lefor, Cheol Woong Jung, Toru Kojima
INTRODUCTION: Pancreas transplantation is the best treatment option in selected patients with type 1 diabetes mellitus. Here we report a patient with a nonmarginal duodenal perforation five years after a simultaneous pancreas-living donor kidney transplantation (SPLKT). PRESENTATION OF CASE: A 31-year old male who underwent SPLKT five years previously presented with severe abdominal pain. He had a marginal duodenal perforation four years later, treated by primary closure and drainage...
July 14, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28738146/high-throughput-structural-and-functional-characterization-of-the-thin-film-materials-system-ni-co-al
#4
Peer Decker, Dennis Naujoks, Dennis Langenkaemper, Christoph Somsen, Alfred Ludwig
High-throughput methods were used to investigate a Ni-Co-Al thin film materials library. This material system is of interest for superalloys and shape memory alloys. High resolution grazing incidence x-ray diffraction (XRD) measurements were carried out to identify the library's phase regions; d-spacing maps, based on peak fitting, were used to determine more precisely the compositional existence regions of phases. Thin film texture, which was observed in XRD, was also addressed. Finally, magneto-optical measurements were performed to confirm the results of the XRD measurements...
July 24, 2017: ACS Combinatorial Science
https://www.readbyqxmd.com/read/28737967/integral-membrane-proteins-bottom-up-top-down-and-structural-proteomics
#5
Upendra Karr, Margaret Simonian, Julian P Whitelegge
Integral membrane proteins and lipids constitute the bilayer membranes that surround cells and sub-cellular compartments, and modulate movements of molecules and information between them. Since membrane protein drug targets represent a disproportionately large segment of the proteome, technical developments need timely review. Areas covered and literature search strategy: Publically available resources such as Pubmed were surveyed. Bottom-up proteomics analyses now allow efficient extraction and digestion such that membrane protein coverage is essentially complete, making up around one third of the proteome...
July 24, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28737923/co-silencing-intestinal-transglutaminase-2-and-interleukin-15-using-gelatin-based-nanoparticles-in-an-in-vitro-model-of-celiac-disease
#6
Husain Attarwala, Valerie Clausen, Prasoon Chaturvedi, Mansoor M Amiji
In this study, we have developed type B gelatin-based nanoparticle based siRNA delivery system for silencing of intestinal transglutaminase-2 (TG2) and interleukin-15 (IL-15) genes in cultured human intestinal epithelial cells (Caco-2) and murine alveolar macrophage cells (J774A.1). Small interfering RNA (siRNA) targeting the TG2 or IL-15 gene was encapsulated within gelatin nanoparticles using ethanol-water solvent displacement method. Size, charge and morphology of gelatin nanoparticles were evaluated using Zetasizer instrument and transmission electron microscopy...
July 24, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28737906/role-of-the-protein-dimeric-interface-in-allosteric-inhibition-of-n-acetyl-aspartate-hydrolysis-by-human-aspartoacylase
#7
Ekaterina D Kots, Sofya V Lushchekina, Sergey D Varfolomeev, Alexander V Nemukhin
The results of molecular modeling suggest a mechanism of allosteric inhibition upon hydrolysis of N-acetyl-aspartate (NAA), one of the most abundant amino acid derivatives in brain, by human aspartoacylase (hAsp). Details of this reaction are important to suggest the practical ways to control the enzyme activity. Search for allosteric sites using the Allosite web server and SiteMap analysis allowed us to identify substrate binding pockets located at the interface between the subunits of the hAsp dimer molecule...
July 24, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28737816/protein-stability-and-dynamics-influenced-by-ligands-in-extremophilic-complexes-a-molecular-dynamics-investigation
#8
Sara Khan, Umar Farooq, Maria Kurnikova
In this study, we explore the structural and dynamic adaptations of the Tryptophan synthase α-subunit in a ligand bound state in psychrophilic, mesophilic and hyperthermophilic organisms at different temperatures by MD simulations. We quantify the global and local fluctuations in the 40 ns time scale by analyzing the root mean square deviation/fluctuations. The distinct behavior of the active site and loop 6 is observed with the elevation of temperature. Protein stability relies more on electrostatic interactions, and these interactions might be responsible for the stability of varying temperature evolved proteins...
July 24, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28737760/channel-opening-and-gating-mechanism-in-ampa-subtype-glutamate-receptors
#9
Edward C Twomey, Maria V Yelshanskaya, Robert A Grassucci, Joachim Frank, Alexander I Sobolevsky
AMPA-subtype ionotropic glutamate receptors mediate fast excitatory neurotransmission throughout the central nervous system. Gated by the neurotransmitter glutamate, AMPA receptors are critical for synaptic strength and dysregulation of AMPA receptor-mediated signalling is linked to numerous neurological diseases. Here, we use cryo-electron microscopy to solve the structures of AMPA receptor-auxiliary subunit complexes in the apo, antagonist and agonist-bound states and elucidate the iris-like mechanism of ion channel opening...
July 24, 2017: Nature
https://www.readbyqxmd.com/read/28737714/parametric-loop-division-for-3d-localization-in-wireless-sensor-networks
#10
Tanveer Ahmad, Xue Jun Li, Boon-Chong Seet
Localization in Wireless Sensor Networks (WSNs) has been an active topic for more than two decades. A variety of algorithms were proposed to improve the localization accuracy. However, they are either limited to two-dimensional (2D) space, or require specific sensor deployment for proper operations. In this paper, we proposed a three-dimensional (3D) localization scheme for WSNs based on the well-known parametric Loop division (PLD) algorithm. The proposed scheme localizes a sensor node in a region bounded by a network of anchor nodes...
July 24, 2017: Sensors
https://www.readbyqxmd.com/read/28737397/conformational-nonequilibrium-enzyme-kinetics-generalized-michaelis-menten-equation
#11
D Evan Piephoff, Jianlan Wu, Jianshu Cao
In a conformational nonequilibrium steady state (cNESS), enzyme turnover is modulated by the underlying conformational dynamics. On the basis of a discrete kinetic network model, we use an integrated probability flux balance method to derive the cNESS turnover rate for a conformation-modulated enzymatic reaction. The traditional Michaelis-Menten (MM) rate equation is extended to a generalized form, which includes non-MM corrections induced by conformational population currents within combined cyclic kinetic loops...
July 24, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28737306/the-use-of-cold-coagulation-for-the-treatment-of-cervical-intraepithelial-neoplasia
#12
A Wyse, W A Seah, J O'Neill, P Byrne
In 2015, Cold Coagulation was introduced as a treatment for cervical intraepithelial neoplasia (CIN) at our colposcopy clinic. We reviewed the 6-month follow up data of the first 200 women who underwent Cold Coagulation using cytology and HPV status as tests of cure (TOC). A random sample of 200 patients treated by Large Loop Excision of the Transformation Zone (LLETZ) during the same period was used to compare treatment outcome. Six months following treatment,173 (86.5%) of the women treated by CC and 167 (83...
May 10, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/28737268/comparison-of-two-minimally-invasive-techniques-for-liver-biopsy-collection-in-dogs
#13
N Fernandez, J Del-Pozo, D Shaw, A I C Marques
OBJECTIVES: High-quality biopsy is an essential factor for the successful diagnosis of canine liver disease. The aim of this study was to compare various aspects of biopsies obtained by two different techniques: pretied ligating loop and cup biopsy forceps. MATERIALS AND METHODS: Fifteen client-owned dogs underwent laparoscopic liver biopsies for diagnosis of liver disease. Biopsies were obtained from the same liver lobe using a pre-tied ligating loop and cup biopsy forceps...
July 24, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28736835/peptide-mimetics-of-immunoglobulin-a-iga-and-fc%C3%AE-ri-block-iga-induced-human-neutrophil-activation-and-migration
#14
Marieke H Heineke, Lydia P E van der Steen, Rianne M Korthouwer, J Joris Hage, Johannes P M Langedijk, Joris J Benschop, Jantine E Bakema, Jerry W Slootstra, Marjolein van Egmond
The cross-linking of the IgA Fc receptor (FcαRI) by IgA induces release of the chemoattractant LTB4, thereby recruiting neutrophils in a positive feedback loop. IgA autoantibodies of patients with autoimmune blistering skin diseases therefore induce massive recruitment of neutrophils, resulting in severe tissue damage. To interfere with neutrophil mobilization and reduce disease morbidity, we developed a panel of specific peptides mimicking either IgA or FcαRI sequences. CLIPS technology was used to stabilize three-dimensional structures and to increase peptides' half-life...
July 24, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28736791/control-of-standing-balance-at-leaning-postures-with-functional-neuromuscular-stimulation-following-spinal-cord-injury
#15
Musa L Audu, Brooke M Odle, Ronald J Triolo
This study systematically explored the potential of applying feedback control of functional neuromuscular stimulation (FNS) for stabilizing various erect and leaning standing postures after spinal cord injury (SCI). Perturbations ranging from 2 to 6% body weight were applied to two subjects with motor complete thoracic level SCI who were proficient at standing with implanted multichannel neural stimulators to activate the ankle, knee, hip and trunk muscles. The subjects stood with four different postures: erect, forward, forward-right and forward-left...
July 24, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28736748/troubleshooting-for-ureteroscopy-complicated-by-unexpected-guidewire-looping-and-entrapment
#16
Ioannis Efthimiou, Zacharias Chousianitis, Kostadinos Skrepetis
This report presents a bizarre and unusual case of looping and entrapment of a hydrophilic guidewire in the ureter of a 65-year-old woman with a stone in the lower ureter at the time of ureteroscopy and laser lithotripsy. We describe endourology maneuvers to remove the retained guidewire. Looping and entrapment of guidewire is a rare complication that urologists may face when they do not follow the basic principles of guidewire insertion. In that case, successful resolution is based both on surgeon's inspiration to apply the appropriate endourology maneuvers and availability of a variety of endourology tools in the theater...
2017: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/28736657/high-temporal-resolution-aberrometry-in-a-50-eye-population-and-implications-for-adaptive-optics-error-budget
#17
Jessica Jarosz, Pedro Mecê, Jean-Marc Conan, Cyril Petit, Michel Paques, Serge Meimon
We formed a database gathering the wavefront aberrations of 50 healthy eyes measured with an original custom-built Shack-Hartmann aberrometer at a temporal frequency of 236 Hz, with 22 lenslets across a 7-mm diameter pupil, for a duration of 20 s. With this database, we draw statistics on the spatial and temporal behavior of the dynamic aberrations of the eye. Dynamic aberrations were studied on a 5-mm diameter pupil and on a 3.4 s sequence between blinks. We noted that, on average, temporal wavefront variance exhibits a n(-2) power-law with radial order n and temporal spectra follow a f(-1...
April 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28736459/final-report-on-the-key-comparison-ccm-p-k15-in-the-pressure-range-from-1-0-%C3%A3-10-4-pa-to-1-0-pa
#18
Christian Wuethrich, Kenta Arai, Mercede Bergoglio, James A Fedchak, Karl Jousten, Seung Soo Hong, Jorge Torres Guzman
The comparison CCM.P-K15 is a key comparison in pressure involving six laboratories in three regional metrological organizations (RMO). The measurand of the comparison is the accommodation coefficient of two spinning rotating gauge characterized in nitrogen from 0.1 mPa up to 1.0 Pa. The two transfer standards were circulated from November 2009 until March 2011. The circulation consisted of three loops, one for each RMO, and a new calibration by the pilot between each loop. The stability of one of the transfer standards was poor and was worse than expected based on the previous history of the transfer standard while the other transfer standard demonstrated good stability while circulated in Europe and America and a fair stability while circulated in Asia...
2017: Metrologia
https://www.readbyqxmd.com/read/28736307/local-striatal-reward-signals-can-be-predicted-from-corticostriatal-connectivity
#19
Peter Smittenaar, Zeb Kurth-Nelson, Siawoosh Mohammadi, Nikolaus Weiskopf, Raymond J Dolan
A defining feature of the basal ganglia is their anatomical organization into multiple cortico-striatal loops. A central tenet of this architecture is the idea that local striatal function is determined by its precise connectivity with cortex, creating a functional topography that is mirrored within cortex and striatum. Here we formally test this idea using both human anatomical and functional imaging, specifically asking whether within striatal subregions one can predict between-voxel differences in functional signals based on between-voxel differences in corticostriatal connectivity...
July 20, 2017: NeuroImage
https://www.readbyqxmd.com/read/28736303/the-good-and-the-bad-collagens-of-fibrosis-their-role-in-signaling-and-organ-function
#20
M A Karsdal, S H Nielsen, D J Leeming, L L Langholm, M J Nielsen, T Manon-Jensen, A Siebuhr, N S Gudmann, S Rønnow, J M Sand, S J Daniels, J H Mortensen, D Schuppan
Usually the dense extracellular structure in fibrotic tissues is described as extracellular matrix (ECM) or simply as collagen. However, fibrosis is not just fibrosis, which is already exemplified by the variant morphological characteristics of fibrosis due to viral versus cholestatic, autoimmune or toxic liver injury, with reticular, chicken wire and bridging fibrosis. Importantly, the overall composition of the ECM, especially the relative amounts of the many types of collagens, which represent the most abundant ECM molecules and which centrally modulate cellular functions and physiological processes, changes dramatically during fibrosis progression...
July 20, 2017: Advanced Drug Delivery Reviews
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