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https://www.readbyqxmd.com/read/29677037/small-left-ventricular-size-is-an-independent-risk-factor-for-ventricular-assist-device-thrombosis
#1
Venkat Keshav Chivukula, Jennifer A Beckman, Anthony R Prisco, Shin Lin, Todd F Dardas, Richard K Cheng, Stephen D Farris, Jason W Smith, Nahush A Mokadam, Claudius Mahr, Alberto Aliseda
The prevalence of ventricular assist device (VAD) therapy has continued to increase due to a stagnant donor supply and growing advanced heart failure (HF) population. We hypothesize that left ventricular (LV) size strongly influences biocompatibility and risk of thrombosis. Unsteady computational fluid dynamics (CFD) was used in conjunction with patient-derived computational modeling and virtual surgery with a standard, apically implanted inflow cannula. A dual-focus approach of evaluating thrombogenicity was employed: platelet-based metrics to characterize the platelet environment and flow-based metrics to investigate hemodynamics...
April 18, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29677033/characterization-of-the-glucocorticoid-receptor-in-children-undergoing-cardiac-surgery
#2
Saul Flores, David S Cooper, Amy M Opoka, Ilias Iliopoulos, Sarah Pluckebaum, Matthew N Alder, Kelli A Krallman, Rashmi D Sahay, Lin Fei, Hector R Wong
OBJECTIVES: Postoperative administration of corticosteroids is common practice for managing catecholamine refractory low cardiac output syndrome. Since corticosteroid activity is dependent on the glucocorticoid receptor, we sought to characterize glucocorticoid receptor levels in children undergoing cardiac surgery and examined the association between glucocorticoid receptor levels and cardiovascular dysfunction. DESIGN: Prospective observational cohort study. SETTING: Large, tertiary pediatric cardiac center...
April 19, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29677032/landiolol-hydrochloride-rapidly-controls-junctional-ectopic-tachycardia-after-pediatric-heart-surgery
#3
Fumiya Yoneyama, Chiho Tokunaga, Hideyuki Kato, Tomomi Nakajima, Bryan J Mathis, Hiroaki Sakamoto, Yuji Hiramatsu
OBJECTIVES: Junctional ectopic tachycardia is a supraventricular tachyarrhythmia with atrioventricular dissociation that causes life-threatening postsurgical conditions in pediatric heart patients. This study evaluates the efficacy of landiolol hydrochloride for managing junctional ectopic tachycardia. DESIGN: A single-center retrospective study. SETTING: PICU at the university hospital. PATIENTS: Of 561 pediatric patients who underwent open-heart surgery between 2006 and 2017, 10 patients developed sustained junctional ectopic tachycardia and were selected for landiolol treatment...
April 19, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29675905/transient-left-anterior-and-septal-fascicular-blocks-after-self-expandable-percutaneous-transcatheter-aortic-valve-implantation
#4
Andrés R Pérez-Riera, Raimundo Barbosa-Barros, Mariana F Cabral de Oliveira, Rodrigo Daminello-Raimundo, Luiz C de Abreu, Kjell Nikus
Transcatheter aortic valve implantation (TAVI) is indicated in severe symptomatic aortic stenosis, when there is intermediate-high surgical risk, or a condition considered inoperable, as in the case of "porcelain aorta" that could turn clamping or cannulation of the ascending aorta hazardous in open-heart surgery. Among the complications of this less invasive procedure, intraventricular conduction disorders subsequent to the procedure stand out. TAVI causes worsening of intraventricular dromotropic disorders in more than 75% of the cases, with the presence of preexisting right bundle branch block and first-degree atrioventricular block, deep prosthesis implant, male gender, size of the aortic annulus smaller than the prosthesis, and porcelain aorta being predictive of requirement for permanent pacemaker implant...
April 19, 2018: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/29675416/free-floating-mesothelial-cells-in-pleural-fluid-after-lung-surgery
#5
Arne Kienzle, Andrew B Servais, Alexandra B Ysasi, Barry C Gibney, Cristian D Valenzuela, Willi L Wagner, Maximilian Ackermann, Steven J Mentzer
Objectives: The mesothelium, the surface layer of the heart, lung, bowel, liver, and tunica vaginalis, is a complex tissue implicated in organ-specific diseases and regenerative biology; however, the mechanism of mesothelial repair after surgical injury is unknown. Previous observations indicated seeding of denuded mesothelium by free-floating mesothelial cells may contribute to mesothelial healing. In this study, we investigated the prevalence of mesothelial cells in pleural fluid during the 7 days following pulmonary surgery...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29675070/frequency-and-outcome-of-acute-neurologic-complications-after-congenital-heart-disease-surgery
#6
Sidra Kaleem Jafri, Lubaina Ehsan, Qalab Abbas, Fatima Ali, Prem Chand, Anwar Ul Haque
Objectives: To determine the frequency and immediate outcome of acute neurologic complications (ANCs) in children undergoing congenital heart surgery (CHS). Materials and Methods: In this retrospective study, all patients undergoing CHS at our hospital from January 2007 to June 2016 were included. Patients were followed up for the development of seizures, altered level of consciousness (ALOC), abnormal movements, and stroke. Results are presented as mean with standard deviation and frequency with percentages...
October 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29674770/incidence-of-pulmonary-complications-with-the-prophylactic-use-of-high-flow-nasal-cannula-after-pediatric-cardiac-surgery-prophylactic-hfnc-study-protocol
#7
Naohiro Shioji, Tomoyuki Kanazawa, Tatsuo Iwasaki, Kazuyoshi Shimizu, Tomohiko Suemori, Hirokazu Kawase, Satoshi Kimura, Yasutoshi Kuroe, Hiroshi Morimatsu
We will investigate the incidence of postoperative pulmonary complications (PPCs) with the prophylactic use of a high-flow nasal cannula (HFNC) after pediatric cardiac surgery. Children < 48 months old with congenital heart disease for whom cardiac surgery is planned will be included. The HFNC procedure will be commenced just after extubation, at a flow rate of 2 L/kg/min with adequate oxygen concentration to achieve target oxygen saturation ≥ 94%. This study will reveal the prevalence of PPCs after pediatric cardiac surgery with the prophylactic use of HFNC...
April 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29674478/quadruple-valve-replacement-in-a-patient-with-severe-rheumatic-heart-disease
#8
Isaac Adembesa, Adriaan Myburgh, Justiaan Swanevelder
INTRODUCTION: RHD is the leading cause of cardiovascular morbidity and mortality among young people. TOE is valuable in confirming valvular heart pathology. DISCUSSION: We present a patient with severe rheumatic heart disease involving all the heart valves. TOE confirmed severe mitral stenosis, severe aortic regurgitation, severe tricuspid regurgitation and stenosis and severe pulmonary stenosis. This was consistent with TTE findings preoperatively. The patient underwent successful quadruple valve replacement in a single operation...
April 19, 2018: Echo Research and Practice
https://www.readbyqxmd.com/read/29673908/mechanism-underlying-the-contractile-activity-of-utp-in-the-mammalian-heart
#9
Ulrich Gergs, Daniel Rothkirch, Britt Hofmann, Hendrik Treede, Bernard Robaye, Andreas Simm, Christa E Müller, Joachim Neumann
We previously reported that uridine 5'-triphosphate (UTP), a pyrimidine nucleoside triphosphate produced a concentration- and time-dependent increase in the contraction force in isolated right atrial preparations from patients undergoing cardiac bypass surgery due to angina pectoris. The stimulation of the force of contraction was sustained rather than transient. In the present study, we tried to elucidate the underlying receptor and signal transduction for this effect of UTP. Therefore, we measured the effect of UTP on force of contraction, phosphorylation of p38 and ERK1/2, in human atrial preparations, atrial preparations from genetically modified mice, cardiomyocytes from adult mice and cardiomyocytes from neonatal rats...
April 16, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29673690/the-role-of-postoperative-radiation-therapy-for-completely-resected-stage-iii-thymoma-and-effect-of-higher-heart-radiation-dose-on-risk-of-cardiovascular-disease-a-retrospective-cohort-study
#10
Jiehao Liao, Tingting Liu, Hongwei Zhang, Feng Cai, Jun Chen, Jun Dang
OBJECTIVES: This study aimed to assess the efficacy of radiation therapy (RT) in patients with completely resected stage III thymoma and evaluate the relationship between higher heart dose and risk of cardiovascular disease (CVD). PATIENTS AND METHODS: A total of 130 consecutive patients with Masaoka stage III thymoma were retrospectively reviewed from January 2003 to December 2013. Of these, 99 underwent complete tumor resection [74 received postoperative radiation therapy (S + R) and 25 received surgery alone (S alone)] and 31 patients underwent RT alone (16 due to inoperable tumors and 15 due to high surgical risk or patient refusal; R alone)...
April 16, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29673639/left-ventricular-diastolic-function-after-aortic-valve-replacement-for-chronic-aortic-regurgitation
#11
Wenrui Ma, Wei Zhang, Wei Shi, Ye Kong, Xinyu Ma
BACKGROUND: The aim of the present study was to investigate the evolution of left ventricular diastolic function after aortic valve replacement (AVR) for chronic severe aortic regurgitation. METHODS: Patients (n=183) who underwent isolated AVR for severe aortic regurgitation were included in this study. Degrees of left ventricular diastolic function were designated, according to the integration of two echocardiographic parameters: left atrial volume index and average E/e' ratio...
April 16, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29673326/surgical-factors-affecting-oculocardiac-reflex-during-strabismus-surgery
#12
Suk-Gyu Ha, Jungah Huh, Bo-Ram Lee, Seung-Hyun Kim
BACKGROUND: To investigate surgical factors associated with the occurrence of oculocardiac reflex (OCR) and changes in heart rate (HR) during strabismus surgery. METHODS: Patients who underwent strabismus surgery under general anesthesia were enrolled in this study. The HR during surgery was measured at baseline, and at the following points during surgery: traction of the muscle, maximal increase after traction (adrenergic phase), and the cutting of the muscle. OCR was defined as an HR reduction of more than 20% at traction of the muscle, when compared to baseline HR...
April 19, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29672815/minimally-invasive-isolated-tricuspid-valve-redo-surgery-a-safety-and-outcome-analysis
#13
Gloria Färber, Sophie Tkebuchava, Rodolfo Siordia Dawson, Hristo Kirov, Mahmoud Diab, Peter Schlattmann, Torsten Doenst
BACKGROUND:  Isolated tricuspid valve (TV) surgery is considered a high risk-procedure. The optimal surgical approach is controversial. We analyzed our experience with isolated TV redo surgery performed either minimally invasively (redo-MITS) or through sternotomy. METHODS:  We retrospectively analyzed all patients with previous cardiac surgery who underwent redo-MITS ( n  = 26) and compared them to redo-Sternotomy ( n  = 17). A group of primary-MITS ( n  = 61) served as control...
April 19, 2018: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29672731/amaze-a-randomized-controlled-trial-of-adjunct-surgery-for-atrial-fibrillation
#14
Samer A M Nashef, Simon Fynn, Yasir Abu-Omar, Tomasz J Spyt, Christine Mills, Colin C Everett, Julia Fox-Rushby, Jeshika Singh, Malcolm Dalrymple-Hay, Catherine Sudarshan, Massimiliano Codispoti, Peter Braidley, Francis C Wells, Linda D Sharples
OBJECTIVES: Atrial fibrillation (AF) reduces survival and quality of life (QoL). It can be treated at the time of major cardiac surgery using ablation procedures ranging from simple pulmonary vein isolation to a full maze procedure. The aim of this study is to evaluate the impact of adjunct AF surgery as currently performed on sinus rhythm (SR) restoration, survival, QoL and cost-effectiveness. METHODS: In a multicentre, Phase III, pragmatic, double-blinded, parallel-armed randomized controlled trial, 352 cardiac surgery patients with >3 months of documented AF were randomized to surgery with or without adjunct maze or similar AF ablation between 2009 and 2014...
April 17, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29670747/percutaneous-management-of-ostial-stenosis-of-the-left-internal-mammary-artery-graft
#15
Tanuka Datta, Mohammed Gibreal, Ramesh Mazhari, Allen J Solomon
A 61-year-old man, who had undergone coronary artery bypass surgery 10 years earlier, presented with a non-ST segment elevation myocardial infarction. He was treated with medical therapy and taken to the Cardiac Catheterization Laboratory. A left heart catheterization demonstrated an ostial stenosis in the left internal mammary artery graft, which was felt to be the culprit lesion. This was successfully repaired with a drug eluting stent. This case is presented as an unusual location for a de novo coronary stenosis...
January 2018: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/29670358/multidisciplinary-approach-to-the-management-of-pulmonary-embolism-patients-the-pulmonary-embolism-response-team-pert
#16
REVIEW
Christopher W Root, David M Dudzinski, Bishoy Zakhary, Oren A Friedman, Akhilesh K Sista, James M Horowitz
Pulmonary embolism (PE) is a potentially fatal disease with a broad range of treatment options that spans multiple specialties. The rapid evolution and expansion of novel therapies to treat PE make it a disease process that is well suited to a multidisciplinary approach. In order to facilitate a rapid, robust response to the diagnosis of PE, some hospitals have established multidisciplinary pulmonary embolism response teams (PERTs). The PERT model is based on existing multidisciplinary teams such as heart teams and rapid response teams...
2018: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/29669701/crizotinib-in-patients-with-advanced-inoperable-inflammatory-myofibroblastic-tumours-with-and-without-anaplastic-lymphoma-kinase-gene-alterations-european-organisation-for-research-and-treatment-of-cancer-90101-create-a-multicentre-single-drug-prospective-non
#17
Patrick Schöffski, Jozef Sufliarsky, Hans Gelderblom, Jean-Yves Blay, Sandra J Strauss, Silvia Stacchiotti, Piotr Rutkowski, Lars H Lindner, Michael G Leahy, Antoine Italiano, Nicolas Isambert, Maria Debiec-Rychter, Raf Sciot, Thomas Van Cann, Sandrine Marréaud, Axelle Nzokirantevye, Sandra Collette, Agnieszka Wozniak
BACKGROUND: An inflammatory myofibroblastic tumour (IMFT) is a rare mesenchymal neoplasm characterised by anaplastic lymphoma kinase (ALK) gene rearrangements. We assessed the activity and safety of crizotinib, a tyrosine kinase inhibitor, targeting ALK in patients with advanced IMFT either with or without ALK alterations. METHODS: We did a multicentre, biomarker-driven, single-drug, non-randomised, open-label, two-stage phase 2 trial (European Organisation for Research and Treatment of Cancer 90101 CREATE) at 13 study sites (five university hospitals and eight specialty clinics) in eight European countries (Belgium, France, Germany, Italy, Netherlands, Poland, Slovakia, and the UK)...
April 12, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29668847/adiponectin-determines-farnesoid-x-receptor-agonism-mediated-cardioprotection-against-post-infarction-remodeling-and-dysfunction
#18
Yunlong Xia, Fuyang Zhang, Shihao Zhao, Yueyang Li, Xiyao Chen, Erhe Gao, Xinyue Xu, Zhenyu Xiong, Xiaomeng Zhang, Jinglong Zhang, Huishou Zhao, Wei Wang, Helin Wang, Yanjie Guo, Yi Liu, Congye Li, Shan Wang, Ling Zhang, Wenjun Yan, Ling Tao
Aims: The farnesoid X receptor (FXR) is a member of the metabolic nuclear receptor superfamily that plays a critical regulatory role in cardiovascular physiology/pathology. However, the role of systemic FXR activation in the chronic phase in myocardial infarction (MI)-induced cardiac remodeling and dysfunction remains unclear. In this study, we aimed to elucidate the role of long-term FXR activation on post-MI cardiac remodeling and dysfunction. Methods and Results: Mice underwent either MI surgery or sham operation...
April 14, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29667902/myocardial-protection-following-del-nido-cardioplegia-in-pediatric-cardiac-surgery
#19
Debasish Panigrahi, Saibal Roychowdhury, Rahul Guhabiswas, Emmanuel Rupert, Mrinalendu Das, Pradeep Narayan
Background This study was designed to compare myocardial protection with del Nido cardioplegia and conventional blood cardioplegia in children undergoing cardiac surgery in Risk Adjustment for Congenital Heart Surgery categories 1 and 2. Methods Sixty patients were randomized into 2 groups receiving del Nido cardioplegia solution or conventional blood cardioplegia. Myocardial injury was assessed using biochemical markers (troponin I and creatine kinase-MB). Vasoactive-inotropic scores were calculated to compare inotropic requirements...
January 1, 2018: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/29667173/efficacy-of-corticosteroids-in-prevention-of-acute-kidney-injury-in-neonates-undergoing-cardiac-surgery-a-randomized-controlled-trial
#20
T Jahnukainen, J Keski-Nisula, J Tainio, H Valkonen, T Pätilä, H Jalanko, P Suominen
BACKGROUND: Heart surgery requiring cardiopulmonary bypass (CPB) causes an inflammatory response which may further induce acute kidney injury (AKI). In the present randomized controlled study we evaluated whether corticosteroids can prevent CPB related AKI in neonates undergoing heart surgery. METHODS: Forty neonates were randomized to receive 2 mg/kg methylprednisolone followed by hydrocortisone infusion 0.2 mg/kg/h perioperatively with tapering doses for 5 days, or placebo administered in a similar fashion...
April 17, 2018: Acta Anaesthesiologica Scandinavica
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