keyword
MENU ▼
Read by QxMD icon Read
search

system change

keyword
https://www.readbyqxmd.com/read/29929207/heart-protective-effects-of-echinodorus-grandiflorus-in-rabbits-that-are-fed-a-high-cholesterol-diet
#1
Francielly Mourão Gasparotto, Francislaine Aparecida Dos Reis Lívero, Rhanany Allan Caloi Palozi, Maria Leticia Ames, Bruna Nunes, Guilherme Donadel, Rita de Cassia Lima Ribeiro, Emerson Luiz Botelho Lourenço, Cândida Aparecida Leite Kassuya, Arquimedes Gasparotto Junior
Excess weight and dyslipidemia are among the most serious health problems in Western societies. These conditions enhance the risk of cardiac disease and have been linked with a higher prevalence of cardiac arrhythmias and sudden death. The present study investigated the cardioprotective effects of Echinodorus grandiflorus on ventricular remodeling in rabbits that were fed a 1% cholesterol-rich diet. We first obtained an ethanol-soluble fraction of E. grandiflorus and performed a detailed phytochemical study by liquid chromatography-DAD/ESI-MS...
June 21, 2018: Planta Medica
https://www.readbyqxmd.com/read/29929161/do-spatiotemporal-parameters-and-gait-variability-differ-across-the-lifespan-of-healthy-adults-a-systematic-review
#2
REVIEW
Nolan Herssens, Evi Verbecque, Ann Hallemans, Luc Vereeck, Vincent Van Rompaey, Wim Saeys
BACKGROUND: Aging is often associated with changes in the musculoskeletal system, peripheral and central nervous system. These age-related changes often result in mobility problems influencing gait performance. Compensatory strategies are used as a way to adapt to these physiological changes. RESEARCH QUESTION: The aim of this review is to investigate the differences in spatiotemporal and gait variability measures throughout the healthy adult life. METHODS: This systematic review was conducted according to the PRISMA guidelines and registered in the PROSPERO database (no...
June 12, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29929144/spatial-and-temporal-variation-of-papyrus-root-mat-thickness-and-water-storage-in-a-tropical-wetland-system
#3
Ellen Jessica Kayendeke, Frank Kansiime, Helen K French, Yazidhi Bamutaze
Papyrus wetlands are predominant in permanently inundated areas of tropical Sub Saharan Africa (SSA) and offer both provisioning and regulatory services. Although a wealth of literature exists on wetland functions, the seasonal behaviour of the papyrus mat and function in water storage has received less attention. The objective of this study was to assess the response of the papyrus root mat to changing water levels in a tropical wetland system in Eastern Uganda. We delineated seven transects through a section of a wetland system and mapped wetland bathymetry along these transects...
June 18, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29929076/updating-energy-security-and-environmental-policy-energy-security-theories-revisited
#4
L Proskuryakova
The energy security theories are based on the premises of sufficient and reliable supply of fossil fuels at affordable prices in centralized supply systems. Policy-makers and company chief executives develop energy security strategies based on the energy security theories and definitions that dominate in the research and policy discourse. It is therefore of utmost importance that scientists revisit these theories in line with the latest changes in the energy industry: the rapid advancement of renewables and smart grid, decentralization of energy systems, new environmental and climate challenges...
June 18, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29929019/the-rehabilitation-of-advanced-heart-failure-patients-after-left-ventricular-assist-device-a-narrative-review
#5
REVIEW
Sarah M Eickmeyer, Kim D Barker, Anjum Sayyad, Leslie Rydberg
As an increasing number of patients with advanced heart failure are receiving a Left Ventricular Assist Device (LVAD) as either destination therapy or bridge to transplantation, there is increasing attention on functional outcomes and quality of life after LVAD implantation. Rehabilitation providers in the acute inpatient rehabilitation setting increasingly will treat patients with LVAD and should understand the exercise physiology, medical management, rehabilitation considerations, and outcomes after rehabilitation for patients with LVAD...
June 18, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29928998/interleukin-1-in-monocyte-activation-phenotypes-in-systemic-juvenile-idiopathic-arthritis-observations-from-a-clinical-trial-of-rilonacept-an-interleukin-1-inhibitor
#6
Yujuan Zhang, Saloni Gupta, Alexandra Ilstad-Minnihan, Sashi Ayyangar, Arielle D Hay, Virginia Pascual, Norman T Ilowite, Claudia Macaubas, Elizabeth D Mellins
Systemic juvenile idiopathic arthritis (sJIA) is a childhood rheumatic disease of unknown origin. Dysregulated innate immunity is implicated in disease pathology. We investigated if IL-1 inhibition affects circulating cytokines and monocyte gene expression. CD14+ monocytes from patients in the RAPPORT trial were analyzed by RT-PCR for expression of IL1B and transcription factors associated with monocyte activation. Serum IL-1ra decreased with treatment, and IL-18BP transiently increased. Serum levels of IL-1β, IL-6, IL-10 and IL-18 were unchanged...
June 18, 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29928995/engineering-folate-targeting-diselenide-containing-triblock-copolymer-as-a-redox-responsive-shell-sheddable-micelle-for-antitumor-therapy-in-vivo
#7
Farnaz Behroozi, Mohammad-Jafar Abdkhodaie, Hamid Sadeghi Abandansari, Leila Satarian, Mohammad Molazem, Khuloud T Al-Jamal, Hossein Baharvand
The oxidation-reduction (redox)-responsive micelle system is based on a diselenide-containing triblock copolymer, poly(ε-caprolactone)-bis(diselenide-methoxy poly(ethylene glycol)/poly(ethylene glycol)-folate) [PCL-(SeSe-mPEG/PEG-FA)2 ]. This has helped in the development of tumor-targeted delivery for hydrophobic anticancer drugs. The diselenide bond, as a redox-sensitive linkage, was designed in such a manner that it is located at the hydrophilic-hydrophobic hinge to allow complete collapse of the micelle and thus efficient drug release in redox environments...
June 18, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29928976/characterization-of-quorum-sensing-system-in-clostridium-chauvoei
#8
Sujeet Kumar, Mohmad Mashooq, Ravi Kumar Gandham, S V Alavandi, Viswas Konasagara Nagaleekar
Clostridium chauvoei causes fatal black quarter infection in cattle and buffaloes. The quorum sensing (QS) system, a bacterial cell to cell communication process, of the pathogen was characterized in the current study. The results indicated that C. chauvoei lacked luxS (autoinducer-2) based quorum sensing as detected by the sensor strain Vibrio harveyi BB170. This was supported by absence of luxS gene in C. chauvoei genome. However, the genomic analysis indicated the presence of agrBD system in all three genomes of C...
June 18, 2018: Anaerobe
https://www.readbyqxmd.com/read/29928924/navigate-ii-randomized-double-blind-trial-of-the-exhalation-delivery-system-with-fluticasone-eds-flu-for-nasal-polyposis
#9
Donald A Leopold, David Elkayam, John C Messina, Colette Kosik-Gonzalez, Per G Djupesland, Ramy A Mahmoud
BACKGROUND: Chronic rhinosinusitis (CRS) is common and sometimes complicated by nasal polyps (NP). Corticosteroid nasal sprays are often unsatisfactory because they are ineffective at delivering medication to high/deep sites of inflammation. OBJECTIVE: Assess whether an exhalation delivery system with fluticasone (EDS-FLU), capable of high/deep drug deposition, improves outcomes. METHODS: Patients (N=323) ≥18 years with moderate-to-severe congestion and NP were randomized to twice-daily EDS-FLU (93, 186, or 372μg) or EDS-placebo for 24 weeks (16 double-blind [DB] plus 8 open-label [OL] when all received 372μg)...
June 18, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29928918/combined-exposure-to-carbon-disulfide-and-low-frequency-noise-reversibly-affects-vestibular-function
#10
Monique Chalansonnet, Maria Carreres-Pons, Thomas Venet, Aurélie Thomas, Lise Merlen, Carole Seidel, Frédéric Cosnier, Hervé Nunge, Benoît Pouyatos, Jordi Llorens, Pierre Campo
Chronic occupational exposure to carbon disulfide (CS2) has debilitating motor and sensory effects in humans, which can increase the risk of falls. Although no mention of vestibulotoxic effects is contained in the literature, epidemiological and experimental data suggest that CS2 could cause low-frequency hearing loss when associated with noise exposure. Low-frequency noise might also perturb the peripheral balance receptor through an as-yet unclear mechanism. Here, we studied how exposure to a low-frequency noise combined with 250-ppm CS2 affected balance in rats...
June 18, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29928801/understanding-the-interplay-between-self-assembling-peptides-and-solution-ions-for-tunable-protein-nanoparticle-formation
#11
Bhuvana Kamath Shanbhag, Chang Liu, Victoria S Haritos, Lizhong He
Protein based nanomaterials are gaining importance in biomedical and biosensor applications where tunability of the protein particle size is highly desirable. Rationally-designed proteins and peptides offer control over molecular interactions between monomeric protein units to modulate their self-assembly and thus particle formation. Here, using an example enzyme-peptide system produced as a single construct by bacterial expression, we explore how solution conditions affect the formation and size of protein nanoparticles...
June 21, 2018: ACS Nano
https://www.readbyqxmd.com/read/29928794/evolution-of-the-us-energy-system-and-related-emissions-under-varying-social-and-technological-development-paradigms-plausible-scenarios-for-use-in-robust-decision-making
#12
Kristen E Brown, Troy Alan Hottle, Rubenka Bandyopadhyay, Samaneh Babaee, Rebecca Susanne Dodder, Pervin Ozge Kaplan, Carol Lenox, Dan Loughlin
The energy system is the primary source of air pollution. Thus, evolution of the energy system into the future will affect society's ability to maintain air quality. Anticipating this evolution is difficult because of inherent uncertainty in predicting future energy demand, fuel use, and technology adoption. We apply Scenario Planning to address this uncertainty, developing four very different visions of the future. Stakeholder engagement suggested technological progress and social attitudes toward the environment are critical and uncertain factors for determining future emissions...
June 21, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29928769/motor-cortical-and-corticospinal-function-differ-during-an-isometric-squat-compared-to-isometric-knee-extension
#13
Callum G Brownstein, Paul Ansdell, Jakob Škarabot, Ash Frazer, Dawson Kidgell, Glyn Howatson, Stuart Goodall, Kevin Thomas
NEW FINDINGS: What is the central question of this study? In order to discern information about testing modalities when assessing neuroplastic responses to squat resistance training, the present study investigated whether corticospinal and intracortical function was different between a joint-angle matched isometric squat, and isometric knee extension. What is the main finding and its importance? The present data shows poor agreement of corticospinal and intracortical function between the isometric squat and isometric knee extension...
June 21, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29928745/modeling-the-role-of-public-health-education-in-ebola-virus-disease-outbreaks-in-sudan
#14
Benjamin Levy, Christina Edholm, Orou Gaoue, Roselyn Kaondera-Shava, Moatlhodi Kgosimore, Suzanne Lenhart, Benjamin Lephodisa, Edward Lungu, Theresia Marijani, Farai Nyabadza
Public involvement in Ebola Virus Disease (EVD) prevention efforts is key to reducing disease outbreaks. Targeted education through practical health information to particular groups and sub-populations is crucial to controlling the disease. In this paper, we study the dynamics of Ebola virus disease in the presence of public health education with the aim of assessing the role of behavior change induced by health education to the dynamics of an outbreak. The power of behavior change is evident in two outbreaks of EVD that took place in Sudan only 3 years apart...
August 2017: Infectious Disease Modelling
https://www.readbyqxmd.com/read/29928696/viscoelastic-properties-of-vimentin-originate-from-nonequilibrium-conformational-changes
#15
Johanna Block, Hannes Witt, Andrea Candelli, Jordi Cabanas Danes, Erwin J G Peterman, Gijs J L Wuite, Andreas Janshoff, Sarah Köster
Structure and dynamics of living matter rely on design principles fundamentally different from concepts of traditional material science. Specialized intracellular filaments in the cytoskeleton permit living systems to divide, migrate, and grow with a high degree of variability and durability. Among the three filament systems, microfilaments, microtubules, and intermediate filaments (IFs), the physical properties of IFs and their role in cellular mechanics are the least well understood. We use optical trapping of individual vimentin filaments to investigate energy dissipation, strain history dependence, and creep behavior of stretched filaments...
June 2018: Science Advances
https://www.readbyqxmd.com/read/29928682/integration-of-sensors-in-gastrointestinal-organoid-culture-for-biological-analysis
#16
REVIEW
Ge-Ah Kim, Nicholas J Ginga, Shuichi Takayama
The gastrointestinal (GI) tract regulates physiologic responses in complex ways beyond facilitating nutrient entry into the circulatory system. Because of the anatomic location of the GI tract, studying in vivo physiology of the human gut, including host cell interaction with the microbiota, is limited. GI organoids derived from human stem cells are gaining interest as they recapitulate in vivo cellular phenotypes and functions. An underdeveloped capability that would further enhance the utility of these miniature models of the GI tract is to use sensors to quantitatively characterize the organoid systems with high spatiotemporal resolution...
2018: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29928658/impact-of-zika-virus-on-adult-human-brain-structure-and-functional-organization
#17
Richard Bido-Medina, Jonathan Wirsich, Minelly Rodríguez, Jairo Oviedo, Isidro Miches, Pamela Bido, Luis Tusen, Peter Stoeter, Sepideh Sadaghiani
Objective: To determine the impact of Zika virus (ZIKV) infection on brain structure and functional organization of severely affected adult patients with neurological complications that extend beyond Guillain-Barré Syndrome (GBS)-like manifestations and include symptoms of the central nervous system (CNS). Methods: In this first case-control neuroimaging study, we obtained structural and functional magnetic resonance images in nine rare adult patients in the subacute phase, and healthy age- and sex-matched controls...
June 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29928643/circulating-protein-biomarkers-in-systemic-sclerosis-related-pulmonary-arterial-hypertension-a-review-of-published-data
#18
REVIEW
Peter M Hickey, Allan Lawrie, Robin Condliffe
Pulmonary arterial hypertension (PAH) develops in 7-12% of patients with systemic sclerosis (SSc) and is associated with a 3 year survival of 52%. Early detection by screening is therefore recommended for all patients with SSc. Historically, screening has been performed using echocardiography and measurement of gas transfer. More recently the DETECT protocol, using a combination of biomarkers (including N-terminal pro-brain natriuretic peptide) and clinical parameters, has been developed. The optimal method of screening for PAH with high sensitivity and specificity is, however, not clear...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29928562/imaging-of-sodium-mri-for-therapy-evaluation-of-brain-metastase-with-cyberknife-at-7t-a-case-report
#19
Lichao Huang, Zihao Zhang, Baolin Qu, Zhiqiang Cui, Yao Wang, Jiwei Li, Jinyuan Wang, Zhentao Zuo, Yan Zhuo, Xinguang Yu, Zhipei Lin, Longsheng Pan
Herein we describe the case of an elderly patient who presented with a recent history of impaired vision of the right eye around three months due to brain lesions. He was diagnosed with liver cancer and underwent surgery three months prior. The pathological result is hepatocellular carcinoma. Magnetic resonance imaging (MRI) revealed the diagnosis of brain to be metastatic. The patient selected CyberKnife (Accuray Incorporated, Sunnyvale, USA) radiosurgery for the brain lesion since his physical conditions are not suitable for craniotomy...
April 18, 2018: Curēus
https://www.readbyqxmd.com/read/29928519/can-muscle-protein-metabolism-be-specifically-targeted-by-exercise-training-in-copd
#20
REVIEW
Davina C M Simoes, Ioannis Vogiatzis
Patients with stable chronic obstructive pulmonary disease (COPD) frequently exhibit unintentional accentuated peripheral muscle loss and dysfunction. Skeletal muscle mass in these patients is a strong independent predictor of morbidity and mortality. Factors including protein anabolism/catabolism imbalance, hypoxia, physical inactivity, inflammation, and oxidative stress are involved in the initiation and progression of muscle wasting in these patients. Exercise training remains the most powerful intervention for reversing, in part, muscle wasting in COPD...
May 2018: Journal of Thoracic Disease
keyword
keyword
76790
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"