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JOURNAL ARTICLE
Hongshen Wan, Yunfei Meng, Zehua Wang, Zhenhui Du
Ultra-low noise is a critical component in the design of high-precision sensor front-ends. We introduced differential phase-sensitive detection (d-PSD) to mitigate both multiplicative and additive noise in optical sensors, aiming for an enhanced performance and cost-effectiveness. The d-PSD combines a capacitive transimpedance amplifier (C-TIA), a delta-sigma analog-to-digital converter (ΔΣ-ADC), and a software-based lock-in amplifier (s-LIA). The first two components utilize the DDC112 (a dual current input 20-bit ADC) for a minimal analog channel length, thus reducing noise efficiently, while the latter employs a cost-effective 32-bit microcontroller unit (MCU), the HC32F460...
March 1, 2024: Review of Scientific Instruments
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JOURNAL ARTICLE
Sebastian Lindblom, Maria Flink, Lena von Koch, Malin Tistad, Una Stenberg, Marie Elf, Axel C Carlsson, Ann Charlotte Laska, Charlotte Ytterberg
INTRODUCTION: Care transitions following a stroke call for integrated care approaches to reduce death and disability. The proposed research described in this study protocol aims to evaluate the effectiveness of a person-centred multicomponent care transition support and the process in terms of contextual moderators, implementation aspects and mechanisms of impact. METHODS: A non-randomized controlled trial design will be used. The intervention includes person-centred dialogue intended to permeate all patient-provider communication, various pedagogical modes of information, a person-centred care and rehabilitation plan, and a bridging e-meeting to prepare patients for homecoming...
2024: PloS One
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JOURNAL ARTICLE
Goo-Han Ko, Seung-Jin Moon, Seong-Hoon Kim, Jeong-Geun Kim, Donghyun Baek
A fully integrated 24-GHz radar transceiver with one transmitter (TX) and two receivers (RXs) for compact frequency modulated continuous wave (FMCW) radar applications is here presented. The FMCW synthesizer was realized using a fractional-N phase-locked loop (PLL) and programmable chirp generator, which are completely integrated in the proposed transceiver. The measured output phase noise of the synthesizer is -80 dBc/Hz at 100 kHz offset. The TX consists of a three-bit bridged t-type attenuator for gain control, a two-stage drive amplifier (DA) and a one-stage power amplifier (PA)...
February 23, 2024: Sensors
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JOURNAL ARTICLE
Zhomart Orman, Muideen T Olaiya, Amanda G Thrift, Dominique A Cadilhac, Thanh Phan, Mark R Nelson, David Ung, Velandai K Srikanth, Christopher F Bladin, Richard P Gerraty, Joseph Phillipos, Joosup Kim
INTRODUCTION: Evidence on the cost-effectiveness of comprehensive post-stroke programs is limited. We assessed the cost-effectiveness of an individualised management program (IMP) for stroke or transient ischaemic attack (TIA). METHODS: A cost-utility analysis alongside a randomised controlled trial with a 2-year follow-up, from both societal and health system perspectives, was conducted. Adults with stroke/TIA discharged from hospitals were randomised by primary care practice to receive either usual care (UC) or an IMP in addition to UC...
February 15, 2024: Neuroepidemiology
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Tia A Tummino, Christos Iliopoulos-Tsoutsouvas, Joao M Braz, Evan S O'Brien, Reed M Stein, Veronica Craik, Ngan K Tran, Suthakar Ganapathy, Fangyu Liu, Yuki Shiimura, Fei Tong, Thanh C Ho, Dmytro S Radchenko, Yurii S Moroz, Sian Rodriguez Rosado, Karnika Bhardwaj, Jorge Benitez, Yongfeng Liu, Herthana Kandasamy, Claire Normand, Meriem Semache, Laurent Sabbagh, Isabella Glenn, John J Irwin, Kaavya Krishna Kumar, Alexandros Makriyannis, Allan I Basbaum, Brian K Shoichet
Large library docking can reveal unexpected chemotypes that complement the structures of biological targets. Seeking new agonists for the cannabinoid-1 receptor (CB1R), we docked 74 million tangible molecules, prioritizing 46 high ranking ones for de novo synthesis and testing. Nine were active by radioligand competition, a 20% hit-rate. Structure-based optimization of one of the most potent of these (K i = 0.7 µM) led to '4042 , a 1.9 nM ligand and a full CB1R agonist. A cryo-EM structure of the purified enantiomer of '4042 ( '1350 ) in complex with CB1R-G i1 confirmed its docked pose...
January 23, 2024: bioRxiv
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JOURNAL ARTICLE
Fabrizio Monaco, Margherita Licheri, Rosa Labanca, Federica Russetti, Alessandro Oriani, Germano Melissano, Roberto Chiesa, Gaia Barucco
OBJECTIVES: The aim of the current study was to assess the relationship among thrombin receptor activator peptide 6 (TRAP test), adenosine-5'-diphosphate (ADP test), arachidonic acid (ASPI test), and stroke/transient ischemic attack (TIA), using the multiple electrode aggregometry (Multiplate) in patients undergoing carotid thromboendarterectomy (CEA). DESIGN: A retrospective study. SETTING: Vascular surgery operating rooms of a university hospital...
December 5, 2023: Journal of Cardiothoracic and Vascular Anesthesia
#7
Jiankun Lyu, Nicholas Kapolka, Ryan Gumpper, Assaf Alon, Liang Wang, Manish K Jain, Ximena Barros-Álvarez, Kensuke Sakamoto, Yoojoong Kim, Jeffrey DiBerto, Kuglae Kim, Tia A Tummino, Sijie Huang, John J Irwin, Olga O Tarkhanova, Yurii Moroz, Georgios Skiniotis, Andrew C Kruse, Brian K Shoichet, Bryan L Roth
AlphaFold2 (AF2) and RosettaFold have greatly expanded the number of structures available for structure-based ligand discovery, even though retrospective studies have cast doubt on their direct usefulness for that goal. Here, we tested unrefined AF2 models prospectively , comparing experimental hit-rates and affinities from large library docking against AF2 models vs the same screens targeting experimental structures of the same receptors. In retrospective docking screens against the σ 2 and the 5-HT2A receptors, the AF2 structures struggled to recapitulate ligands that we had previously found docking against the receptors' experimental structures, consistent with published results...
December 21, 2023: bioRxiv
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JOURNAL ARTICLE
Xiao An, Yan Zhang, Zhirui Li, Yuxiang Song, Jiying Chen
OBJECTIVE: Blood pressure (BP) fluctuation has been demonstrated to be closely associated with stroke. However, at present, no attention is paid to the BP fluctuation following total knee arthroplasty (TKA). The aim of this study is to investigate what is BP fluctuation patterns in stroke and transient ischemic attack (TIA) patients after primary TKA, compare clinical characteristics among different BP fluctuation patterns and determine whether it could predict the occurrence of a 90-day stroke...
December 19, 2023: Orthopaedic Surgery
#9
JOURNAL ARTICLE
Mahziar Serri Mazandarani, Gabriel Gagnon-Turcotte, Reza Papi, Benoit Gosselin
This paper presents ultra-low power photoplethysmography (PPG) readout circuits. The proposed system architecture uses a current buffer between the photodiode (PD) and the transimpedance amplifier (TIA) to isolate the large parasitic capacitance of the PD leading to improves the power consumption of the TIA. A class AB topology is exploited at the output of the amplifier, which allows for increased drive capability without the use of auxiliary circuits. The maximum input current range of the TIA is 160 µA, so the large DC current of the input signal does not saturate the circuit...
July 2023: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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JOURNAL ARTICLE
Sarah Cargnin, Federica Ferrari, Salvatore Terrazzino
PURPOSE: Inconclusive and limited results have been reported on the clinical utility of CYP2C19 genotyping in stroke/TIA patients of non-East Asian ancestries. We herein performed an updated systematic review and meta-analysis to quantitatively estimate the association of CYP2C19 loss-of function (LOF) status with efficacy and safety of clopidogrel-based antiplatelet therapy in non-East Asian patients affected by stroke or TIA. METHODS: A comprehensive search was performed up to July 2023 using PubMed, Web of Knowledge, and Cochrane Library databases...
December 1, 2023: Cardiovascular Drugs and Therapy
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REVIEW
Iman Chehregani Rad, Amir Azimi
INTRODUCTION: A range of screening tools has been developed to assist emergency healthcare providers in rapidly and accurately diagnosing strokes. In this study, we investigated the diagnostic value of the Recognition of Stroke in the Emergency Room (ROSIER) scale in identifying individuals with stroke and transient ischemic attack (TIA). METHODS: We conducted a systematic search across online databases of PubMed, Embase, Scopus, and Web of Science until June 12th, 2023, aiming to identify studies that assessed the diagnostic performance of the ROSIER scale in detecting strokes and TIAs among individuals with suspected stroke symptoms...
2023: Archives of Academic Emergency Medicine
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JOURNAL ARTICLE
Kelsey M Haas, Michael J McGregor, Mehdi Bouhaddou, Benjamin J Polacco, Eun-Young Kim, Thong T Nguyen, Billy W Newton, Matthew Urbanowski, Heejin Kim, Michael A P Williams, Veronica V Rezelj, Alexandra Hardy, Andrea Fossati, Erica J Stevenson, Ellie Sukerman, Tiffany Kim, Sudhir Penugonda, Elena Moreno, Hannes Braberg, Yuan Zhou, Giorgi Metreveli, Bhavya Harjai, Tia A Tummino, James E Melnyk, Margaret Soucheray, Jyoti Batra, Lars Pache, Laura Martin-Sancho, Jared Carlson-Stevermer, Alexander S Jureka, Christopher F Basler, Kevan M Shokat, Brian K Shoichet, Leah P Shriver, Jeffrey R Johnson, Megan L Shaw, Sumit K Chanda, Dan M Roden, Tonia C Carter, Leah C Kottyan, Rex L Chisholm, Jennifer A Pacheco, Maureen E Smith, Steven J Schrodi, Randy A Albrecht, Marco Vignuzzi, Lorena Zuliani-Alvarez, Danielle L Swaney, Manon Eckhardt, Steven M Wolinsky, Kris M White, Judd F Hultquist, Robyn M Kaake, Adolfo García-Sastre, Nevan J Krogan
Influenza A Virus (IAV) is a recurring respiratory virus with limited availability of antiviral therapies. Understanding host proteins essential for IAV infection can identify targets for alternative host-directed therapies (HDTs). Using affinity purification-mass spectrometry and global phosphoproteomic and protein abundance analyses using three IAV strains (pH1N1, H3N2, H5N1) in three human cell types (A549, NHBE, THP-1), we map 332 IAV-human protein-protein interactions and identify 13 IAV-modulated kinases...
September 27, 2023: Nature Communications
#13
JOURNAL ARTICLE
Shushu Liu, Ting Chen, Wei Wu
OBJECTIVE: To investigate the predictive value of Whole Brain CT Perfusion (WB-CTP) combined with the ABCD3 score in patients with transient ischemic attack (TIA). METHODS: A total of 336 TIA patients with TIA underwent WB-CTP and ABCD3 score assessment within 48 h of admission. Spearman correlation test was performed to analyze the relationship between the degree of vascular stenosis, relative perfusion values, and ABCD3 score. Logistic regression analysis was used to identify independent risk factors for secondary cerebral infarction...
2023: Frontiers in Neurology
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JOURNAL ARTICLE
Chang Wang, Avery B Peterson, Ka Kit Wong, Molly E Roseland, Matthew J Schipper, Yuni K Dewaraja
Estimation of the time-integrated activity (TIA) for dosimetry from imaging at a single time point (STP) facilitates the clinical translation of dosimetry-guided radiopharmaceutical therapy. However, the accuracy of the STP methods for TIA estimation varies on the basis of time-point selection. We constructed patient data-driven regression models to reduce the sensitivity to time-point selection and to compare these new models with commonly used STP methods. Methods: SPECT/CT performed at time period (TP) 1 (3-5 h), TP2 (days 1-2), TP3 (days 3-5), and TP4 (days 6-8) after cycle 1 of [177 Lu]Lu-DOTATATE therapy involved 27 patients with 100 segmented tumors and 54 kidneys...
July 27, 2023: Journal of Nuclear Medicine
#15
REVIEW
Shima Shahjouei, Homa Seyedmirzaei, Vida Abedi, Ramin Zand
A transient ischemic attack (TIA), a constellation of temporary neurological symptoms, precedes stroke in one-fifth of patients. Thus far, many clinical models have been introduced to optimize the quality, time to treatment, and cost of acute TIA care, either in an inpatient or outpatient setting. In this article, we aim to review the characteristics and outcomes of outpatient TIA clinics across the globe. In addition, we discussed the main challenges for outpatient management of TIA, including triage and diagnosis, and the system dynamics of the clinics...
July 5, 2023: Journal of Clinical Medicine
#16
JOURNAL ARTICLE
Christos Salis, Rawand Jarrar, Laura L Murray
PURPOSE: The dual-task paradigm has been frequently used to examine stroke-related deficits because it samples behavioral performance under conditions of distraction similar to functioning in real-life environments. This original systematic review synthesizes studies that examined dual-task effects involving spoken language production in adults affected by stroke, including transient ischemic attack (TIA) and poststroke aphasia. METHOD: Five databases were searched (inception to March 2022) for eligible peer-reviewed articles...
August 3, 2023: Journal of Speech, Language, and Hearing Research: JSLHR
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JOURNAL ARTICLE
Hongyu Zhou, Weiqi Chen, Yue Suo, Xia Meng, Xingquan Zhao, Mengxing Wang, Liping Liu, Hao Li, Yuesong Pan, Yongjun Wang
BACKGROUND: There is a close brain-kidney interaction following ischemic cerebrovascular disease. The new-onset kidney injury after stroke leads to severe neurological deficits and poor functional outcomes. We aimed to validate the Nelson equation for predicting the new-onset and long-term kidney function decline in patients with acute ischemic stroke (AIS) or transient ischemic attack (TIA). METHODS: A total of 3169 patients were enrolled in the Third China National Stroke Registry, whose baseline estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1...
2023: Clinical Interventions in Aging
#18
JOURNAL ARTICLE
Antony P McNamee, Tia A Griffith, Amanda G Smith, Lennart Kuck, Michael J Simmonds
Ex vivo hemocompatibility testing is a vital element of preclinical assessment for blood-contacting medical devices. Current approaches are resource intensive; thus, we investigated the feasibility of accelerating hemocompatibility testing by standardizing the number of pump exposures in loops of various sizes. Three identical blood loops were constructed, each with a custom-molded reservoir able to facilitate large-volume expansion. Using the HVAD rotary blood pump operating at 5 L·min-1 and 100 mmHg, three test volumes (80, 160, and 320 ml) were circulated for 4000 pump exposures...
June 1, 2023: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
#19
JOURNAL ARTICLE
Ya-Fang Liao, Hui-Jun Pan, Nuerziba Abudurezeke, Chun-Lu Yuan, Yan-Li Yuan, Shu-Da Zhao, Dan-Dan Zhang, Shuang Huang
Glioblastoma (GBM) is the most aggressive brain tumor, with high mortality. Timosaponin AIII (TIA), a steroidal saponin isolated from the medicinal plant Anemarrhena asphodeloides Bge., has been shown to possess anticancer properties in various cancer types. However, the effect of TIA on GBM is unknown. In this study, we reveal that TIA not only inhibited U87MG in vitro cell growth but also in vivo tumor development. Moreover, we found that the cause of TIA-induced cell growth suppression was apoptosis. When seeking to uncover antitumor mechanisms of TIA, we found that TIA diminished the expression of cGMP-specific phosphodiesterase 5(PDE5) while elevating the levels of guanylate cyclases (sGCβ), cellular cGMP, and phosphorylation of VASPser239 ...
April 28, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#20
JOURNAL ARTICLE
Kirsty Ward, Andy Vail, Alan Cameron, Mira Katan, Gregory Yh Lip, Jesse Dawson, Craig J Smith, Amit K Kishore
BACKGROUND: Several molecular biomarkers are available that predict newly detected atrial fibrillation (NDAF). We aimed to identify such biomarkers that predict NDAF after an Ischaemic stroke (IS)/Transient Ischaemic Attack (TIA) and evaluate their performance. METHODS: A systematic review was undertaken in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Studies of patients with IS, TIA, or both, who underwent ECG monitoring for ⩾24 h, which reported molecular biomarkers and frequency of NDAF after electronic searches of multiple databases were included...
March 2023: European Stroke Journal
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