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https://www.readbyqxmd.com/read/29792064/the-effect-and-importance-of-physical-activity-on-behavioural-and-psychological-symptoms-in-people-with-dementia-a-systematic-mixed-studies-review
#1
Tina Junge, Jonas Ahler, Hans K Knudsen, Hanne K Kristensen
Background People with dementia may benefit from the effect of physical activity on behavioural and psychological symptoms of dementia. Qualitative synthesis of the importance of physical activity might complement and help clarify quantitative findings on this topic. The purpose of this systematic mixed studies review was to evaluate findings from both quantitative and qualitative methods about the effect and importance of physical activity on behavioural and psychological symptoms of dementia in people with dementia...
January 1, 2018: Dementia
https://www.readbyqxmd.com/read/29791513/vaccine-induced-antibodies-to-herpes-simplex-virus-glycoprotein-d-epitopes-involved-in-virus-entry-and-cell-to-cell-spread-correlate-with-protection-against-genital-disease-in-guinea-pigs
#2
Lauren M Hook, Tina M Cairns, Sita Awasthi, Benjamin D Brooks, Noah T Ditto, Roselyn J Eisenberg, Gary H Cohen, Harvey M Friedman
Herpes simplex virus type 2 (HSV-2) glycoprotein D (gD2) subunit antigen is included in many preclinical candidate vaccines. The rationale for including gD2 is to produce antibodies that block crucial gD2 epitopes involved in virus entry and cell-to-cell spread. HSV-2 gD2 was the only antigen in the Herpevac Trial for Women that protected against HSV-1 genital infection but not HSV-2. In that trial, a correlation was detected between gD2 ELISA titers and protection against HSV-1, supporting the importance of antibodies...
May 23, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29790953/identifying-and-avoiding-off-target-effects-of-rnase-h-dependent-antisense-oligonucleotides-in-mice
#3
Peter H Hagedorn, Malene Pontoppidan, Tina S Bisgaard, Marco Berrera, Andreas Dieckmann, Martin Ebeling, Marianne R Møller, Heidi Hudlebusch, Marianne L Jensen, Henrik F Hansen, Troels Koch, Morten Lindow
Antisense oligonucleotides that are dependent on RNase H for cleavage and subsequent degradation of complementary RNA are being developed as therapeutics. Besides the intended RNA target, such oligonucleotides may also cause degradation of unintended RNA off-targets by binding to partially complementary target sites. Here, we characterized the global effects on the mouse liver transcriptome of four oligonucleotides designed as gapmers, two targeting Apob and two targeting Pcsk9, all in different regions on their respective intended targets...
May 22, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29790436/evaluating-the-role-of-genetic-variation-in-the-epigenome-in-health-and-disease
#4
Tina Roostaei, Philip L De Jager
No abstract text is available yet for this article.
May 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29790165/igg1-b-cell-immunity-predates-ige-responses-in-epicutaneous-sensitization-to-foods
#5
Rodrigo Jiménez-Saiz, Yosef Ellenbogen, Joshua Koenig, Melissa E Gordon, Tina D Walker, Domenico Rosace, Paul Spill, Kelly Bruton, Joshua Kong, Kristin Monteiro, Jianping Wen, Elaine I Tuomanen, Roland Kolbeck, Derek K Chu, Susan Waserman, Manel Jordana
BACKGROUND: The generation of IgE-mediated food allergy in humans is silent, and only diagnosed upon manifestation of clinical symptoms. While experimental models have been used to investigate some mechanisms of allergic sensitization, the generation of humoral immunity and memory remain to be elucidated. Here, we defined the evolution of allergen-specific B cell responses during epicutaneous sensitization to foods. METHODS: Wild-type and genetic knockout animals, and drug or antibody strategies for cell depletion and immunoglobulin signaling blockade were used to investigate epicutaneous sensitization and disease progression; we analyzed allergen-specific germinal centers and IgG1+ memory B cells by flow cytometry, evaluated humoral responses and determined clinical reactivity (anaphylaxis)...
May 22, 2018: Allergy
https://www.readbyqxmd.com/read/29789878/nuts-as-a-replacement-for-carbohydrates-in-the-diabetic-diet-a-reanalysis-of-a-randomised-controlled-trial
#6
David J A Jenkins, Cyril W C Kendall, Benoît Lamarche, Monica S Banach, Korbua Srichaikul, Edward Vidgen, Sandy Mitchell, Tina Parker, Stephanie Nishi, Balachandran Bashyam, Russell J de Souza, Christopher Ireland, Sathish C Pichika, Joseph Beyene, John L Sievenpiper, Robert G Josse
AIMS/HYPOTHESIS: In line with current advice, we assessed the effect of replacing carbohydrate consumption with mixed nut consumption, as a source of unsaturated fat, on cardiovascular risk factors and HbA1c in type 2 diabetes. The data presented here are from a paper that was retracted at the authors' request ( https://doi.org/10.2337/dc16-rt02 ) owing to lack of adjustment for repeated measures in the same individual. Our aim, therefore, was to fix the error and add new complementary data of interest, including information on clotting factors and LDL particle size...
May 23, 2018: Diabetologia
https://www.readbyqxmd.com/read/29789651/analysis-of-the-genomic-landscape-of-multiple-myeloma-highlights-novel-prognostic-markers-and-disease-subgroups
#7
Niccolo Bolli, Giulia Biancon, Matahi Moarii, Silvia Gimondi, Yilong Li, Chiara de Philippis, Francesco Maura, Vijitha Sathiaseelan, Yu-Tzu Tai, Laura Mudie, Sarah O'Meara, Keiran Raine, Jon W Teague, Adam P Butler, Cristiana Carniti, Moritz Gerstung, Tina Bagratuni, Efstathios Kastritis, Meletios Dimopoulos, Paolo Corradini, Kenneth C Anderson, Philippe Moreau, Stephane Minvielle, Peter J Campbell, Elli Papaemmanuil, Herve Avet-Loiseau, Nikhil C Munshi
In multiple myeloma, next-generation sequencing (NGS) has expanded our knowledge of genomic lesions, and highlighted a dynamic and heterogeneous composition of the tumor. Here we used NGS to characterize the genomic landscape of 418 multiple myeloma cases at diagnosis and correlate this with prognosis and classification. Translocations and copy number abnormalities (CNAs) had a preponderant contribution over gene mutations in defining the genotype and prognosis of each case. Known and novel independent prognostic markers were identified in our cohort of proteasome inhibitor and immunomodulatory drug-treated patients with long follow-up, including events with context-specific prognostic value, such as deletions of the PRDM1 gene...
May 22, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29788443/pediatric-infectious-diseases-meets-the-future
#8
Janet R Gilsdorf, Paul Spearman, Janet A Englund, Tina Q Tan, Kristina A Bryant
Pediatric infectious diseases physicians are dedicated to the diagnosis, prevention, and management of infections in children. As such, we play large, and important, roles in the clinical care of children from birth to late adolescence and in infection prevention, antimicrobial stewardship, research pertaining to infections, public health, international and global health, and advocacy for children's health. Furthermore, we are critical to the education of future physicians (in general), pediatricians, and infectious diseases doctors...
May 19, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29787525/lithium-batteries-a-technological-advance-with-unintended-injury-consequences
#9
Tina L Palmieri, Jay Yelon, David Shapiro, Thomas Duncan, Deborah Kuhls
No abstract text is available yet for this article.
May 15, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29787407/identifying-barriers-to-implementation-of-the-national-partnership-for-maternal-safety-obstetric-hemorrhage-bundle-at-a-tertiary-center-utilization-of-the-delphi-method
#10
Annemaria De Tina, Anthony Chau, Daniela A Carusi, Julian N Robinson, Lawrence C Tsen, Michaela K Farber
BACKGROUND: In 2015, the National Partnership for Maternal Safety (NPMS) developed an obstetric hemorrhage consensus bundle to provide birthing facilities in the United States with consistent, validated practice guidelines for postpartum hemorrhage management. The process of implementing each bundle element at a large tertiary labor and delivery unit has not been described; we sought to identify practice deficiencies and perceived barriers to bundle implementation among multidisciplinary providers...
May 21, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29785618/a-quick-and-simple-benchtop-vortex-egg-disruption-approach-for-the-molecular-diagnosis-of-fasciola-hepatica-from-ruminant-faecal-samples
#11
Nichola Eliza Davies Calvani, Tina Cheng, Christine Green, Patrick Hughes, Emily Kwan, Elizabeth Maher, Russell David Bush, Jan Šlapeta
Commonly employed diagnostic methods for Fasciola spp., such as a traditional sedimentation and faecal egg count, or a commercially available coprological ELISA, have limitations in their sensitivity or ability to differentiate species. A reliable DNA isolation method coupled with real-time PCR addresses these issues by providing highly sensitive and quantitative molecular diagnosis from faecal samples. The current study evaluated a standard benchtop vortex for F. hepatica egg disruption in sheep and cattle faecal samples and determined the minimum faecal egg load required for a positive result from un-concentrated (raw) faecal samples...
May 22, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29785091/health-related-quality-of-life-in-type-2-diabetes-mellitus-patients-with-different-risk-for-obstructive-sleep-apnea
#12
Kresimir Gabric, Andrija Matetic, Marino Vilovic, Tina Ticinovic Kurir, Doris Rusic, Tea Galic, Ivana Jonjic, Josko Bozic
Purpose: Our study primarily aimed to investigate health-related quality of life (HRQoL) in type 2 diabetes mellitus (T2DM) patients with different risk for obstructive sleep apnea (OSA). Patients and methods: This cross-sectional, questionnaire-based study included 466 adult patients with T2DM on regular visit to Center for Diabetes of University Hospital of Split from April to September 2017. All subjects underwent detailed anamnestical evaluation and physical examination with anthropometric measurements...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29783633/butyrylation-of-maize-and-potato-starches-and-characterization-of-the-products-by-nuclear-magnetic-resonance-and-in-vitro-fermentation
#13
Tina Skau Nielsen, Nuria Canibe, Flemming Hofmann Larsen
Intake of butyrylated starches may increase colonic butyrate supply, which can be of public health and clinical benefit by maintaining colonic health. The objective was to investigate if an organocatalytic method with tartaric acid as a catalyst could be applied to produce butyrylated products from different starch sources and to characterize their chemical structure and fermentation capability by using solid-state 13 C MAS NMR (magic angle spinning nuclear magnetic resonance) spectroscopy and an in vitro fermentation model, respectively...
May 18, 2018: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/29783002/a-stepwise-approach-to-laparoscopic-enucleation-and-excision-of-retroperitoneal-cysts
#14
Haider Jan, Tina Kapoor, Vishalli Ghai
STUDY OBJECTIVE: Technical video demonstrating a step by step approach to laparoscopic enucleation and excision of retroperitoneal cysts. DESIGN: Technical video (Canadian Task Force classification III). SETTING: Benign Gynecology Department at a University Hospital. INTERVENTION: Laparoscopic enucleation and excision of retroperitoneal cysts. CONCLUSION: Retroperitoneal cysts are rare lesions associated with numerous complications including compression on neighbouring organs, infection, rupture and malignant transformation...
May 18, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29782179/early-intravascular-events-are-associated-with-development-of-ards
#15
Raja-Elie E Abdulnour, Tina Gunderson, Ioanna Barkas, Jack Y Timmons, Cindy Barnig, Michelle Gong, Daryl J Kor, Ognjen Gajic, Daniel Talmor, Rickey E Carter, Bruce D Levy
RATIONALE: The acute respiratory distress syndrome (ARDS) is a devastating illness with limited therapeutic options. A better understanding of early biochemical and immunological events in ARDS could inform the development of new preventive and treatment strategies. OBJECTIVE: To determine select peripheral blood lipid mediator and leukocyte responses in patients at-risk for ARDS. METHODS: Patients at risk for ARDS were randomized as part of a multicenter, double-blind clinical trial of aspirin versus placebo (LIPS-A; NCT01504867)...
May 21, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29781629/finding-peace-of-mind-when-there-still-is-so-much-left-undone-a-diary-study-on-how-job-stress-competence-need-satisfaction-and-proactive-work-behavior-contribute-to-work-related-rumination-during-the-weekend
#16
Oliver Weigelt, Christine J Syrek, Antje Schmitt, Tina Urbach
Unfinished work tasks have been identified as a significant job-related stressor in recent occupational stress research. Extending this research, we examine how and when not finishing one's tasks by the end of the work week affects work-related rumination at the weekend. Drawing on control theory, we examined competence need satisfaction as a mediating mechanism that links unfinished tasks at the end of the work week to work-related rumination at the weekend. Furthermore, we scrutinized whether proactive work behavior within the work week may neutralize the detrimental effects of unfinished tasks on competence need satisfaction and rumination...
May 21, 2018: Journal of Occupational Health Psychology
https://www.readbyqxmd.com/read/29781471/translational-research-unit-development-of-nursing-standards-and-practice-within-a-specialized-unit-for-participants-in-early-phase-clinical-trials
#17
Theresa Rudnitzki, Tina Curtis, Julie Griffie
BACKGROUND: A growing need exists to ensure safe and skilled oncology nursing care for an increasing number of patients enrolled in phases 1 and 1/2 clinical trials and to provide detailed adherence to protocol administration. This can be best accomplished in a dedicated area for patients in early phase clinical trials. OBJECTIVES: Nursing standards and practice within a newly established translational research unit at an academic medical center were developed. METHODS: A portion of an existing outpatient infusion room composed of 13 beds and a sub-waiting room with 2 chairs was designated for placement of patients enrolled in early phase clinical trials...
June 1, 2018: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/29777429/review-of-clinical-trial-settings-of-drugs-commonly-used-in-primary-care-and-approved-between-2005-and-2012
#18
Jason R Crossley, Tina P Tan, Keisha Herbin Smith, Joseph S Ross, Daniel J Merenstein
No abstract text is available yet for this article.
May 18, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29775997/improved-acmg-compliant-in-silico-prediction-of-pathogenicity-for-missense-substitutions-encoded-by-tp53-variants
#19
Cristina Fortuno, Paul A James, Erin L Young, Bing Feng, Magali Olivier, Tina Pesaran, Sean V Tavtigian, Amanda B Spurdle
Clinical interpretation of germline missense variants represents a major challenge, including those in the TP53 Li-Fraumeni syndrome gene. Bioinformatic prediction is a key part of variant classification strategies. We aimed to optimize the performance of the Align-GVGD tool used for p53 missense variant prediction, and compare its performance to other bioinformatic tools (SIFT, PolyPhen-2) and ensemble methods (REVEL, BayesDel). Reference sets of assumed pathogenic and assumed benign variants were defined using functional and/or clinical data...
May 18, 2018: Human Mutation
https://www.readbyqxmd.com/read/29774482/the-effect-of-subclinical-varicocele-on-pregnancy-rates-and-semen-parameters-a-systematic-review-and-meta-analysis
#20
REVIEW
Taylor P Kohn, Samuel J Ohlander, Jake S Jacob, Tina M Griffin, Larry I Lipshultz, Alexander W Pastuszak
PURPOSE OF REVIEW: Current guidelines recommend against surgical repair of subclinical varicoceles (SCVs) for infertility; several studies demonstrate mixed fertility results after SCV correction. To determine whether surgical correction of SCV improves semen parameters and/or reproductive outcomes, we performed a systematic review and meta-analysis. Seven biomedical literature databases were searched through January 2018 for studies that assessed reproductive outcomes and/or change in semen parameters in men with corrected SCV compared to either (1) uncorrected SCV or (2) corrected clinical varicocele...
May 17, 2018: Current Urology Reports
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