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Ashwini patil

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https://www.readbyqxmd.com/read/29762638/timexnet-web-identifying-cellular-response-networks-from-diverse-omics-time-course-data
#1
Phit Ling Tan, Yosvany López, Kenta Nakai, Ashwini Patil
Summary: Condition-specific time-course omics profiles are frequently used to study cellular response to stimuli and identify associated signaling pathways. However, few online tools allow users to analyze multiple types of high-throughput time-course data. TimeXNet Web is a web server that extracts a time-dependent gene/protein response network from time-course transcriptomic, proteomic or phospho-proteomic data, and an input interaction network. It classifies the given genes/proteins into time-dependent groups based on the time of their highest activity and identifies the most probable paths connecting genes/proteins in consecutive groups...
May 14, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29621407/critical-review-on-the-analytical-methods-for-the-estimation-of-clofazimine-in-bulk-biological-fluids-and-pharmaceutical-formulations
#2
Tulshidas S Patil, Ashwini S Deshpande, Shirish Deshpande
Clofazimine (CFZ), a riminophenazine derivative and a crucial drug in the treatment of lepromatous leprosy, has been reintroduced clinically to treat multidrug-resistant tuberculosis. CFZ holds both antimycobacterial and anti-inflammatory properties. But, due to its highly hydrophobic, polar and photosensitive nature, it is challenging to extract and quantify the drug from different biological fluids and its pharmaceutical formulations. This has also hampered the pharmacokinetic evaluation of the CFZ. This article accentuates various analytical methods viz...
April 5, 2018: Critical Reviews in Analytical Chemistry
https://www.readbyqxmd.com/read/29617862/generation-of-tumor-antigen-specific-murine-cd8-t-cells-with-enhanced-anti-tumor-activity-via-highly-efficient-crispr-cas9-genome-editing
#3
Yasuo Ouchi, Ashwini Patil, Yusuke Tamura, Hiroshi Nishimasu, Aina Negishi, Sudip Kumar Paul, Naoki Takemura, Takeshi Satoh, Yasumasa Kimura, Makoto Kurachi, Osamu Nureki, Kenta Nakai, Hiroshi Kiyono, Satoshi Uematsu
Immunotherapies have led to the successful development of novel therapies for cancer. However, there is increasing concern regarding the adverse effects caused by non-tumor-specific immune responses. Here, we report an effective strategy to generate high-avidity tumor-antigen-specific CTLs, using Cas9/single-guide RNA (sgRNA) ribonucleoprotein (RNP) delivery. As a proof-of-principle demonstration, we selected the gp100 melanoma-associated tumor antigen, and cloned the gp100-specific high-avidity TCR from gp100-immunized mice...
April 3, 2018: International Immunology
https://www.readbyqxmd.com/read/29603703/radiographic-assessment-of-anatomy-of-nasopalatine-canal-for-dental-implant-placement-a-cone-beam-computed-tomographic-study
#4
Jaligama B Rao, Pramod Tatuskar, Ashwini Pulla, Naveen Kumar, Swati C Patil, Ila Tiwari
AIM: The aim of this study is to assess the morphology of nasopalatine canal (NPC) with cone beam computed tomography (CBCT). MATERIALS AND METHODS: A total of 460 subjects of both genders were subjected to CBCT with NewTom machine, and sagittal and coronal sections were used for evaluation of the shape of NPC and width of buccal cortical plate. Types of NPC were also assessed. RESULTS: Of 460 subjects, males were 210 and females were 250...
March 1, 2018: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29561179/targeting-pulmonary-tuberculosis-using-nanocarrier-based-dry-powder-inhalation-current-status-and-futuristic-need
#5
Tulshidas S Patil, Ashwini S Deshpande, Shirish Deshpande, Pravin Shende
Tuberculosis (TB) is a disease caused by the pathogen Mycobacterium tuberculosis. Prolonged administration of high dose antibiotics using oral and injectable routes and their associated side effects, show limitations to successful treatment outcome of TB. Nanocarrier-based dry powder inhalers (DPIs) may provide a breakthrough as an alternative therapeutic approach because of their stable, non-invasive nature and ability to target the drug at the site of infection. The current review focuses on the roadmap of the respiratory system, drug deposition and targeting at the site of infection via pulmonary route...
March 21, 2018: Journal of Drug Targeting
https://www.readbyqxmd.com/read/29416247/effect-of-the-addition-of-rocuronium-to-2-lignocaine-in-peribulbar-block-for-cataract-surgery
#6
Vishalakshi Patil, Allauddin Farooqy, Balaraju Thayappa Chaluvadi, Vinayak Rajashekhar, Ashwini Malshetty
Background and Aims: Peribulbar anesthesia is associated with delayed orbital akinesia compared with retrobulbar anesthesia. To test the hypothesis that rocuronium added to a mixture of local anesthetics (LAs) could improve speed of onset of akinesia in peribulbar block (PB), we designed this study. This study examined the effects of adding rocuronium 5 mg to 2% lignocaine with adrenaline to note orbital and eyelid akinesia in patients undergoing cataract surgery. Material and Methods: In a prospective, randomized, double-blind study, 100 patients were equally randomized to receive a mixture of 0...
October 2017: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29360926/opal-prediction-of-morf-regions-in-intrinsically-disordered-protein-sequences
#7
Ronesh Sharma, Gaurav Raicar, Tatsuhiko Tsunoda, Ashwini Patil, Alok Sharma
Motivation: Intrinsically disordered proteins lack stable 3-dimensional structure and play a crucial role in performing various biological functions. Key to their biological function are the molecular recognition features (MoRFs) located within long disordered protein sequences. Computationally identifying these MoRFs is a challenging task. In this study, we present a new MoRF predictor, OPAL, to identify MoRFs in disordered protein sequences. Method: OPAL utilizes two independent sources of information computed using different component predictors whose scores are processed and combined using common averaging method...
January 18, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29348527/the-human-muscarinic-acetylcholine-receptor-antagonist-dicyclomine-targets-signal-transduction-genes-and-inhibits-the-virulence-factors-in-the-human-pathogen-candida-albicans
#8
Awad Ali, Ashwini Jadhav, Priyanka Jangid, Rajendra Patil, Amruta Shelar, Sankunny Mohan Karuppayil
Dicyclomine is a human muscarinic acetylcholine receptor antagonist used for the treatment of abdominal cramps. We are reporting here that dicyclomine can inhibit the in vitro growth and virulence factors of the human pathogen Candida albicans very effectively. Dicyclomine inhibited adhesion, early biofilm, mature biofilm, and planktonic growth. Yeast to hyphal form transition of C. albicans in various inducer media such as serum, proline, glucose, and N-acetylglucosamine was inhibited. Dicyclomine also could kill C...
March 2018: Journal of Antibiotics
https://www.readbyqxmd.com/read/29220295/once-a-week-versus-once-every-3-weeks-cisplatin-chemoradiation-for-locally-advanced-head-and-neck-cancer-a-phase-iii-randomized-noninferiority-trial
#9
Vanita Noronha, Amit Joshi, Vijay Maruti Patil, Jaiprakash Agarwal, Sarbani Ghosh-Laskar, Ashwini Budrukkar, Vedang Murthy, Tejpal Gupta, Anil K D'Cruz, Shripad Banavali, Prathamesh S Pai, Pankaj Chaturvedi, Devendra Chaukar, Nikhil Pande, Arun Chandrasekharan, Vikas Talreja, Dilip Harindran Vallathol, Vijayalakshmi Mathrudev, Aparna Manjrekar, Kamesh Maske, Arati Sanjay Bhelekar, Kavita Nawale, Sadhana Kannan, Vikram Gota, Atanu Bhattacharjee, Shubhada Kane, Shashikant L Juvekar, Kumar Prabhash
Purpose Chemoradiation with cisplatin 100 mg/m2 given once every 3 weeks is the standard of care in locally advanced head and neck squamous cell cancer (LAHNSCC). Increasingly, low-dose once-a-week cisplatin is substituted because of perceived lower toxicity and convenience. However, there is no level 1 evidence of comparable efficacy to cisplatin once every 3 weeks. Patients and Methods In this phase III randomized trial, we assessed the noninferiority of cisplatin 30 mg/m2 given once a week compared with cisplatin 100 mg/m2 given once every 3 weeks, both administered concurrently with curative intent radiotherapy in patients with LAHNSCC...
April 10, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29165024/evaluation-of-separate-role-of-intestine-and-liver-in-first-pass-metabolism-of-budesonide-in-rat
#10
Amol A Raje, Radni D Deshpande, Vishal V Pathade, Vallabh Mahajan, Kaushal Joshi, Ashwini Tambe, Ramana Jinugu, Vamsi L M Madgula, Ashwani Gaur, Vishwottam Kandikere, Chandragouda R Patil, Kasim A Mookhtiar
1. Budesonide, a potent topical corticosteroid, reported to have low oral bioavailability in mice, rat, dog and human due to rapid first pass metabolism. However, there is insufficient information available in literature regarding the role of intestine and or liver responsible for the first pass metabolism of budesonide. 2. Current study in rats investigates the role of intestine and liver in first pass metabolism of budesonide using two in vivo models. Additionally, budesonide was also evaluated in in vitro assays such as thermodynamic solubility, permeability in Caco-2 cells and stability in simulated gastric (SGF), intestinal fluids (SIF) to understand the underlaying cause for low oral bioavailability...
November 28, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29042212/morfpred-plus-computational-identification-of-morfs-in-protein-sequences-using-physicochemical-properties-and-hmm-profiles
#11
Ronesh Sharma, Maitsetseg Bayarjargal, Tatsuhiko Tsunoda, Ashwini Patil, Alok Sharma
MOTIVATION: Intrinsically Disordered Proteins (IDPs) lack stable tertiary structure and they actively participate in performing various biological functions. These IDPs expose short binding regions called Molecular Recognition Features (MoRFs) that permit interaction with structured protein regions. Upon interaction they undergo a disorder-to-order transition as a result of which their functionality arises. Predicting these MoRFs in disordered protein sequences is a challenging task. METHOD: In this study, we present MoRFpred-plus, an improved predictor over our previous proposed predictor to identify MoRFs in disordered protein sequences...
October 16, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28942919/organism-level-analysis-of-vaccination-reveals-networks-of-protection-across-tissues
#12
Motohiko Kadoki, Ashwini Patil, Cornelius C Thaiss, Donald J Brooks, Surya Pandey, Deeksha Deep, David Alvarez, Ulrich H von Andrian, Amy J Wagers, Kenta Nakai, Tarjei S Mikkelsen, Magali Soumillon, Nicolas Chevrier
A fundamental challenge in immunology is to decipher the principles governing immune responses at the whole-organism scale. Here, using a comparative infection model, we observe immune signal propagation within and between organs to obtain a dynamic map of immune processes at the organism level. We uncover two inter-organ mechanisms of protective immunity mediated by soluble and cellular factors. First, analyzing ligand-receptor connectivity across tissues reveals that type I IFNs trigger a whole-body antiviral state, protecting the host within hours after skin vaccination...
October 5, 2017: Cell
https://www.readbyqxmd.com/read/28930279/comparative-evaluation-of-oxidative-stress-modulating-and-dna-protective-activities-of-aqueous-and-methanolic-extracts-of-acacia-catechu
#13
Ashwini Patil, Manisha Modak
Background: Plant-derived bioactive compounds are becoming immensely important as potential drugs. Different solvents are being used for extraction of these phytochemicals. Evaluation of biological activities of aqueous plant extracts is important as water soluble compounds would be more beneficial with respect to certification, safety and commercial issues. Oxidative stress is involved in development of many diseases; therefore, antioxidants are now being looked upon as convincing therapeutics against such diseases...
September 5, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28922057/the-dietary-food-components-capric-acid-and-caprylic-acid-inhibit-virulence-factors-in-candida-albicans-through-multitargeting
#14
Ashwini Jadhav, Supriya Mortale, Shivkrupa Halbandge, Priyanka Jangid, Rajendra Patil, Wasudev Gade, Kiran Kharat, Sankunny Mohan Karuppayil
Capric acid and caprylic acid are the dietary food components. They are found to inhibit the virulence factors like morphogenesis, adhesion, and biofilm formation in the human pathogenic yeast Candida albicans. Our study demonstrated that yeast-to-hyphal signal transduction pathways were affected by capric acid and caprylic acid. The expression profile of genes associated with serum-induced morphogenesis showed reduced expressions of Cdc35, Hwp1, Hst7, and Cph1 by the treatment with both the fatty acids. Cell elongation gene, Ece1, was surprisingly downregulated by 5208-fold by the treatment of caprylic acid...
November 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28898697/chronic-cigarette-smoke-induced-epigenomic-changes-precede-sensitization-of-bronchial-epithelial-cells-to-single-step-transformation-by-kras-mutations
#15
Michelle Vaz, Stephen Y Hwang, Ioannis Kagiampakis, Jillian Phallen, Ashwini Patil, Heather M O'Hagan, Lauren Murphy, Cynthia A Zahnow, Edward Gabrielson, Victor E Velculescu, Hariharan P Easwaran, Stephen B Baylin
We define how chronic cigarette smoke-induced time-dependent epigenetic alterations can sensitize human bronchial epithelial cells for transformation by a single oncogene. The smoke-induced chromatin changes include initial repressive polycomb marking of genes, later manifesting abnormal DNA methylation by 10 months. At this time, cells exhibit epithelial-to-mesenchymal changes, anchorage-independent growth, and upregulated RAS/MAPK signaling with silencing of hypermethylated genes, which normally inhibit these pathways and are associated with smoking-related non-small cell lung cancer...
September 11, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28717613/morphometric-evaluation-of-human-tendocalcaneus-a-cadaveric-study-of-south-indian-male-population
#16
Naveen Kumar, Ashwini P Aithal, Satheesha B Nayak, Jyothsna Patil, Abhinitha Padavinangadi, Biswa Bina Ray
INTRODUCTION: Tendocalcaneus or Achilles tendon is formed by the fusion of the tendons of gastrocnemius and soleus muscles. Normal morphometric measurements of tendo-calcaneus serves an important landmark in its anthropometric evaluation and biomechanical characteristics. Hence the objective of this study was to provide detailed morphometric profile of tendocalcaneus in south indian cadaveric male population. MATERIALS AND METHOD: A total of 64 dissected adult limbs was studied...
January 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28439158/trigemino-cardiac-reflex-a-phenomenon-neglected-in-maxillofacial-surgery
#17
Udupikrishna M Joshi, Ashwini Munnangi, Kundan Shah, Satishkumar G Patil, Nitin Thakur
BACKGROUND: Trigemino-cardiac reflex is a physiologic response of the body to pressure effects in the region of distribution of the trigeminal nerve. Oral and maxillofacial surgical procedures can induce the development of this reflex, which leads to significant changes in the heart rate and sinus rhythms. This study intends to evaluate the effects of this reflex in patients with facial fractures and its subsequent management. PATIENTS AND METHODS: A total of thirty-seven patients with facial fractures who reported to the Department of Oral and Maxillofacial Surgery at Basaveswar Teaching and General Hospital, Gulbarga during a period from July 2015-March 2016 were considered for the study...
June 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28409362/the-antibacterial-agent-moxifloxacin-inhibits-virulence-factors-of-candida-albicans-through-multitargeting
#18
Ashwini Jadhav, Bhagyashree Bansode, Datta Phule, Amruta Shelar, Rajendra Patil, Wasudev Gade, Kiran Kharat, Sankunny Mohan Karuppayil
Fluoroquinolines are broad spectrum fourth generation antibiotics. Some of the Fluoroquinolines exhibit antifungal activity. We are reporting the potential mechanism of action of a fluoroquinoline antibiotic, moxifloxacin on the growth, morphogenesis and biofilm formation of the human pathogen Candida albicans. Moxifloxacin was found to be Candidacidal in nature. Moxifloxacin seems to inhibit the yeast to Hyphal morphogenesis by affecting signaling pathways. It arrested the cell cycle of C. albicans at S phase...
May 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28155710/predicting-morfs-in-protein-sequences-using-hmm-profiles
#19
Ronesh Sharma, Shiu Kumar, Tatsuhiko Tsunoda, Ashwini Patil, Alok Sharma
BACKGROUND: Intrinsically Disordered Proteins (IDPs) lack an ordered three-dimensional structure and are enriched in various biological processes. The Molecular Recognition Features (MoRFs) are functional regions within IDPs that undergo a disorder-to-order transition on binding to a partner protein. Identifying MoRFs in IDPs using computational methods is a challenging task. METHODS: In this study, we introduce hidden Markov model (HMM) profiles to accurately identify the location of MoRFs in disordered protein sequences...
December 22, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27795644/the-facial-skeleton-armor-to-the-brain
#20
Satishkumar G Patil, Bindu S Patil, Udupikrishna Joshi, Soumya Allurkar, Sharanabasappa Japatti, Ashwini Munnangi
BACKGROUND: With the development of urban setting worldwide, the major issue of concern is the increase in the mortality rate in the population due to road traffic accidents. The face, being the most exposed region is susceptible to injuries and maybe associated with injuries to the adjacent neuro-cranium. The literature has conflicting views on the relationship between facial fractures and head injuries with some authors opining that the facial skeleton cushions the brain while some other authors claim that the facial fractures act as indicators for head injuries...
September 2016: Indian Journal of Dentistry
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