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Ashwini patil

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https://www.readbyqxmd.com/read/29165024/evaluation-of-separate-role-of-intestine-and-liver-in-first-pass-metabolism-of-budesonide-in-rat
#1
Amol A Raje, Radni D Deshpande, Vishal V Pathade, Vallabh Mahajan, Kaushal Joshi, Ashwini Tambe, Ramana Jinugu, Vamsi L M Madgula, Ashwani Gaur, Vishwottam Kandikere, Chandragouda R Patil, Kasim A Mookhtiar
1. Budesonide, a potent topical corticosteroid, reported to have low oral bioavailability in mice, rat, dog and human due to rapid first pass metabolism. However, there is insufficient information available in literature regarding the role of intestine and or liver responsible for the first pass metabolism of budesonide. 2. Current study in rats investigates the role of intestine and liver in first pass metabolism of budesonide using two in vivo models. Additionally, budesonide was also evaluated in in vitro assays such as thermodynamic solubility, permeability in Caco-2 cells and stability in simulated gastric (SGF), intestinal fluids (SIF) to understand the underlaying cause for low oral bioavailability...
November 22, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29042212/morfpred-plus-computational-identification-of-morfs-in-protein-sequences-using-physicochemical-properties-and-hmm-profiles
#2
Ronesh Sharma, Maitsetseg Bayarjargal, Tatsuhiko Tsunoda, Ashwini Patil, Alok Sharma
MOTIVATION: Intrinsically Disordered Proteins (IDPs) lack stable tertiary structure and they actively participate in performing various biological functions. These IDPs expose short binding regions called Molecular Recognition Features (MoRFs) that permit interaction with structured protein regions. Upon interaction they undergo a disorder-to-order transition as a result of which their functionality arises. Predicting these MoRFs in disordered protein sequences is a challenging task. METHOD: In this study, we present MoRFpred-plus, an improved predictor over our previous proposed predictor to identify MoRFs in disordered protein sequences...
October 16, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28942919/organism-level-analysis-of-vaccination-reveals-networks-of-protection-across-tissues
#3
Motohiko Kadoki, Ashwini Patil, Cornelius C Thaiss, Donald J Brooks, Surya Pandey, Deeksha Deep, David Alvarez, Ulrich H von Andrian, Amy J Wagers, Kenta Nakai, Tarjei S Mikkelsen, Magali Soumillon, Nicolas Chevrier
A fundamental challenge in immunology is to decipher the principles governing immune responses at the whole-organism scale. Here, using a comparative infection model, we observe immune signal propagation within and between organs to obtain a dynamic map of immune processes at the organism level. We uncover two inter-organ mechanisms of protective immunity mediated by soluble and cellular factors. First, analyzing ligand-receptor connectivity across tissues reveals that type I IFNs trigger a whole-body antiviral state, protecting the host within hours after skin vaccination...
October 5, 2017: Cell
https://www.readbyqxmd.com/read/28930279/comparative-evaluation-of-oxidative-stress-modulating-and-dna-protective-activities-of-aqueous-and-methanolic-extracts-of-acacia-catechu
#4
Ashwini Patil, Manisha Modak
Background: Plant-derived bioactive compounds are becoming immensely important as potential drugs. Different solvents are being used for extraction of these phytochemicals. Evaluation of biological activities of aqueous plant extracts is important as water soluble compounds would be more beneficial with respect to certification, safety and commercial issues. Oxidative stress is involved in development of many diseases; therefore, antioxidants are now being looked upon as convincing therapeutics against such diseases...
September 5, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28922057/the-dietary-food-components-capric-acid-and-caprylic-acid-inhibit-virulence-factors-in-candida-albicans-through-multitargeting
#5
Ashwini Jadhav, Supriya Mortale, Shivkrupa Halbandge, Priyanka Jangid, Rajendra Patil, Wasudev Gade, Kiran Kharat, Sankunny Mohan Karuppayil
Capric acid and caprylic acid are the dietary food components. They are found to inhibit the virulence factors like morphogenesis, adhesion, and biofilm formation in the human pathogenic yeast Candida albicans. Our study demonstrated that yeast-to-hyphal signal transduction pathways were affected by capric acid and caprylic acid. The expression profile of genes associated with serum-induced morphogenesis showed reduced expressions of Cdc35, Hwp1, Hst7, and Cph1 by the treatment with both the fatty acids. Cell elongation gene, Ece1, was surprisingly downregulated by 5208-fold by the treatment of caprylic acid...
September 18, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28898697/chronic-cigarette-smoke-induced-epigenomic-changes-precede-sensitization-of-bronchial-epithelial-cells-to-single-step-transformation-by-kras-mutations
#6
Michelle Vaz, Stephen Y Hwang, Ioannis Kagiampakis, Jillian Phallen, Ashwini Patil, Heather M O'Hagan, Lauren Murphy, Cynthia A Zahnow, Edward Gabrielson, Victor E Velculescu, Hariharan P Easwaran, Stephen B Baylin
We define how chronic cigarette smoke-induced time-dependent epigenetic alterations can sensitize human bronchial epithelial cells for transformation by a single oncogene. The smoke-induced chromatin changes include initial repressive polycomb marking of genes, later manifesting abnormal DNA methylation by 10 months. At this time, cells exhibit epithelial-to-mesenchymal changes, anchorage-independent growth, and upregulated RAS/MAPK signaling with silencing of hypermethylated genes, which normally inhibit these pathways and are associated with smoking-related non-small cell lung cancer...
September 11, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28717613/morphometric-evaluation-of-human-tendocalcaneus-a-cadaveric-study-of-south-indian-male-population
#7
Naveen Kumar, Ashwini P Aithal, Satheesha B Nayak, Jyothsna Patil, Abhinitha Padavinangadi, Biswa Bina Ray
INTRODUCTION: Tendocalcaneus or Achilles tendon is formed by the fusion of the tendons of gastrocnemius and soleus muscles. Normal morphometric measurements of tendo-calcaneus serves an important landmark in its anthropometric evaluation and biomechanical characteristics. Hence the objective of this study was to provide detailed morphometric profile of tendocalcaneus in south indian cadaveric male population. MATERIALS AND METHOD: A total of 64 dissected adult limbs was studied...
January 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28439158/trigemino-cardiac-reflex-a-phenomenon-neglected-in-maxillofacial-surgery
#8
Udupikrishna M Joshi, Ashwini Munnangi, Kundan Shah, Satishkumar G Patil, Nitin Thakur
BACKGROUND: Trigemino-cardiac reflex is a physiologic response of the body to pressure effects in the region of distribution of the trigeminal nerve. Oral and maxillofacial surgical procedures can induce the development of this reflex, which leads to significant changes in the heart rate and sinus rhythms. This study intends to evaluate the effects of this reflex in patients with facial fractures and its subsequent management. PATIENTS AND METHODS: A total of thirty-seven patients with facial fractures who reported to the Department of Oral and Maxillofacial Surgery at Basaveswar Teaching and General Hospital, Gulbarga during a period from July 2015-March 2016 were considered for the study...
June 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28409362/the-antibacterial-agent-moxifloxacin-inhibits-virulence-factors-of-candida-albicans-through-multitargeting
#9
Ashwini Jadhav, Bhagyashree Bansode, Datta Phule, Amruta Shelar, Rajendra Patil, Wasudev Gade, Kiran Kharat, Sankunny Mohan Karuppayil
Fluoroquinolines are broad spectrum fourth generation antibiotics. Some of the Fluoroquinolines exhibit antifungal activity. We are reporting the potential mechanism of action of a fluoroquinoline antibiotic, moxifloxacin on the growth, morphogenesis and biofilm formation of the human pathogen Candida albicans. Moxifloxacin was found to be Candidacidal in nature. Moxifloxacin seems to inhibit the yeast to Hyphal morphogenesis by affecting signaling pathways. It arrested the cell cycle of C. albicans at S phase...
May 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28155710/predicting-morfs-in-protein-sequences-using-hmm-profiles
#10
Ronesh Sharma, Shiu Kumar, Tatsuhiko Tsunoda, Ashwini Patil, Alok Sharma
BACKGROUND: Intrinsically Disordered Proteins (IDPs) lack an ordered three-dimensional structure and are enriched in various biological processes. The Molecular Recognition Features (MoRFs) are functional regions within IDPs that undergo a disorder-to-order transition on binding to a partner protein. Identifying MoRFs in IDPs using computational methods is a challenging task. METHODS: In this study, we introduce hidden Markov model (HMM) profiles to accurately identify the location of MoRFs in disordered protein sequences...
December 22, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27795644/the-facial-skeleton-armor-to-the-brain
#11
Satishkumar G Patil, Bindu S Patil, Udupikrishna Joshi, Soumya Allurkar, Sharanabasappa Japatti, Ashwini Munnangi
BACKGROUND: With the development of urban setting worldwide, the major issue of concern is the increase in the mortality rate in the population due to road traffic accidents. The face, being the most exposed region is susceptible to injuries and maybe associated with injuries to the adjacent neuro-cranium. The literature has conflicting views on the relationship between facial fractures and head injuries with some authors opining that the facial skeleton cushions the brain while some other authors claim that the facial fractures act as indicators for head injuries...
September 2016: Indian Journal of Dentistry
https://www.readbyqxmd.com/read/27751309/paraganglioma-masquerading-as-acute-myocardial-infarction-and-cardiogenic-shock
#12
Tanveer Ahmad, Shankaragouda Patil, Ashwini Kumar Pasarad, Nandakumar Neralakere Maheshwarappa, Kolkebaile Sadanand Kishore
Paragangliomas, extra-adrenal pheochromocytomas, are rare catecholamine-secreting tumor. A 34-year-old lady admitted with diagnosis of ST elevation acute myocardial infarction with cardiogenic shock. Left ventricular function, severely depressed, returned to normal after initial stabilization. Coronary angiogram was normal. A para-aortic paraganglioma was diagnosed during the patient's work-up with biochemical studies, computed tomography of abdomen and functional radioisotopes imaging and was eventually surgically resected...
September 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/27486279/role-of-pet-ct-scan-in-gynaeconcology
#13
Ashwini A Pawar, Digvijay B Patil, Shilpa Patel, Meeta Mankad, Pariseema Dave
THE PURPOSE OF THIS STUDY: This study was undertaken to evaluate the role of positron emission tomography-CT (PET-CT) in diagnosis and management of gynecological malignancies in primary and recurrent settings and also to investigate its role in inappropriately treated patients, for pretreatment evaluation (staging) to help in proper therapeutic management. METHOD: This is a retrospective study of 56 patients of gynecological malignancy registered in Gujarat Cancer Research Institute from June 2011 to December 2013...
October 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27366267/supratentorial-endodermal-cysts-report-of-two-cases
#14
Vithal Rangarajan, Amit Mahore, Manoj Kashinath Patil, Ashwini Dnyandaevrao Shendarkar
We describe two rare cases of frontal cystic lesions presenting with symptoms and signs of raised intracranial pressure. Both had a preoperative diagnosis of an arachnoid cyst and were subjected to a craniotomy with marsupialization of the cyst. However, the histology confirmed them to be an endodermal cyst (EC) on both occasions. Both the patients have been closely followed with no recurrence of symptoms. ECs of the central nervous system are usually reported in the spinal canal, mid-line posterior fossa, and the suprasellar regions...
July 2016: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/27242691/molecular-characterization-and-meta-analysis-of-gut-microbial-communities-illustrate-enrichment-of-prevotella-and-megasphaera-in-indian-subjects
#15
Shrikant Bhute, Pranav Pande, Sudarshan A Shetty, Rahul Shelar, Sachin Mane, Shreyas V Kumbhare, Ashwini Gawali, Hemal Makhani, Mohit Navandar, Dhiraj Dhotre, Himangi Lubree, Dhiraj Agarwal, Rutuja Patil, Shantanu Ozarkar, Saroj Ghaskadbi, Chittaranjan Yajnik, Sanjay Juvekar, Govind K Makharia, Yogesh S Shouche
The gut microbiome has varied impact on the wellbeing of humans. It is influenced by different factors such as age, dietary habits, socio-economic status, geographic location, and genetic makeup of individuals. For devising microbiome-based therapies, it is crucial to identify population specific features of the gut microbiome. Indian population is one of the most ethnically, culturally, and geographically diverse, but the gut microbiome features remain largely unknown. The present study describes gut microbial communities of healthy Indian subjects and compares it with the microbiota from other populations...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27190783/unusual-and-unique-variant-branches-of-lateral-cord-of-brachial-plexus-and-its-clinical-implications-a-cadaveric-study
#16
Ashwini Aithal Padur, Naveen Kumar, Swamy Ravindra Shanthakumar, Surekha Devadas Shetty, Gayathri Sharath Prabhu, Jyothsna Patil
INTRODUCTION: Adequate knowledge on variant morphology of brachial plexus and its branches are important in clinical applications pertaining to trauma and surgical procedures of the upper extremity. AIM: Current study was aimed to report variations of the branches of the lateral cord of brachial plexus in the axilla and their possible clinical complications. MATERIALS AND METHODS: Total number of 82 upper limbs from 41 formalin embalmed cadavers was dissected...
April 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27076454/impact-of-squamous-differentiation-in-breast-carcinoma
#17
Trupti Pai, Tanuja Shet, Sangeeta Desai, Asawari Patil, Nita Nair, Vani Parmar, Sudeep Gupta, Ashwini Budrukkar, Rajiv Sarin, Rajendra Badwe
This study attempted to review the impact of extent of squamous differentiation in 56 infiltrating duct carcinomas (IDC) with squamous differentiation (metaplastic squamous carcinomas [MSC]). Tumors showing 100% squamous elements were labeled as primary squamous carcinomas (PSC; n = 28) and compared with 28 MSC showing lesser squamous components. A clinicopathological comparison revealed that lymphovascular emboli were never seen in any PSC but were noted in 7/28 of other MSC, while perineural invasion was seen only in PSC and not in MSC...
September 2016: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27006857/safety-and-effectiveness-of-total-thyroidectomy-and-its-comparison-with-subtotal-thyroidectomy-and-other-thyroid-surgeries-a-systematic-review
#18
REVIEW
Ashwini Aithal Padur, Naveen Kumar, Anitha Guru, Satheesha Nayak Badagabettu, Swamy Ravindra Shanthakumar, Murlimanju Bukkambudhi Virupakshamurthy, Jyothsna Patil
Diseases associated with the thyroid gland are one of the most frequently seen endocrine disorders across the globe. Total thyroidectomy is currently the preferred treatment for many thyroid diseases. Controversies exist among surgeons regarding safety of total thyroidectomy due to the risk associated with it like postoperative hypoparathyroidism or recurrent laryngeal nerve damage. Since, in the recent years, the incidence of thyroidectomy is in increasing trend in south Indian population, this review aims to study the available data regarding the appropriateness and safety of total thyroidectomy and compares it with subtotal thyroidectomy and other thyroid surgeries...
2016: Journal of Thyroid Research
https://www.readbyqxmd.com/read/26813938/bilateral-multiple-variations-in-carotid-arteries-a-case-report
#19
Sulabha Hanumant Deshpande, Ashwini Balasaheb Nuchhi, Balappa Murigeppa Bannur, Babasaheb Gurusiddappagouda Patil
The common carotid arteries are the largest bilateral arteries of the head and neck. The common carotid arteries may bifurcate higher or lower than the usual levels. A higher bifurcation is more common. Tortuous arteries if present may be asymptomatic if it is mild but may lead to ischaemia of the organs if severe. The cause could be genetic, or may be thickening of the arteries. During routine dissection of an adult male cadaver in the department of Anatomy, BLDEU's Shri BM Patil Medical college, Vijaypur, we found the bilateral multiple variations in the carotid arteries regarding the bifurcation level of common carotid arteries, tortuous external and internal carotid arteries and the number of branches arising from external carotid arteries...
December 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26708988/hitpredict-version-4-comprehensive-reliability-scoring-of-physical-protein-protein-interactions-from-more-than-100-species
#20
Yosvany López, Kenta Nakai, Ashwini Patil
HitPredict is a consolidated resource of experimentally identified, physical protein-protein interactions with confidence scores to indicate their reliability. The study of genes and their inter-relationships using methods such as network and pathway analysis requires high quality protein-protein interaction information. Extracting reliable interactions from most of the existing databases is challenging because they either contain only a subset of the available interactions, or a mixture of physical, genetic and predicted interactions...
2015: Database: the Journal of Biological Databases and Curation
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