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Magnesium AND diabetes

Casey M Rebholz, Adrienne Tin, Yang Liu, Marie Fanelli Kuczmarski, Michele K Evans, Alan B Zonderman, Deidra C Crews
BACKGROUND: Prior studies suggest that certain aspects of the diet related to magnesium intake, such as dietary acid load, protein intake and dietary patterns rich in fruits and vegetables, may impact kidney disease risk. We hypothesized that lower dietary magnesium intake would be prospectively associated with more rapid kidney function decline. METHODS: Among participants in the Healthy Aging in Neighborhoods of Diversity across the Life Span study with estimated glomerular filtration rate (eGFR) ≥60 ml/min/1...
October 22, 2016: American Journal of Nephrology
Jie Wei, Chao Zeng, Xiao-Xiao Li, Qian-Yi Gong, Guang-Hua Lei, Tu-Bao Yang
BACKGROUND: A number of studies have reported the association between magnesium (Mg) and diabetes. However, the various conclusions were inconsistent and the data on the Chinese population was limited. The objective of this study was to evaluate the association among dietary Mg, serum Mg, and diabetes in Chinese adults. METHODS: A cross-sectional study that contained 2904 subjects was conducted. Biochemical test results and dietary intakes of subjects were collected for analysis...
October 18, 2016: Journal of Health, Population, and Nutrition
Zheping Yuan, Chengguo Liu, Yiping Tian, Xuhui Zhang, Huaizhuang Ye, Lifeng Jin, Liansheng Ruan, Zhanhang Sun, Yimin Zhu
Magnesium (Mg) and calcium (Ca) are essential for numerous kinds of metabolisms in human body. To investigate the associations between Mg and Ca and the ratio of Ca to Mg (Ca/Mg) in whole blood with metabolic syndrome (MetS) in a Chinese population, a matched case-control study including 204 MetS patients and 204 healthy controls (aged 48-89) was carried out in 2011. MetS were diagnosed according to the criteria of Chinese Diabetes Society. Controls had no abnormal metabolic components and were matched with cases by age, gender and region...
October 18, 2016: Annals of Nutrition & Metabolism
Marion G Priebe, Jolene R McMonagle
BACKGROUND: In many countries breakfast cereals are an important component of breakfast. This systematic review assesses the contribution of consumption of ready-to eat cereal (RTEC) to the recommended nutrient intake. Furthermore, the effects of RTEC consumption on key health parameters are investigated as well as health promoting properties of RTEC. METHOD: The Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE and CINAHL have been searched up till 16th of June 2015...
2016: PloS One
S Gibiino, A Trappoli, B Balzarro, A R Atti, D De Ronchi
A 71-year-old man developed coma with severe respiratory failure, hypotension, and tachycardia induced by the intentional ingestion of quetiapine fumarate extended release (XR) 20 g. At the time, he had been treated for bipolar depression with venlafaxine 75 mg/day, lamotrigine 100 mg/day, pregabalin 75 mg/day, and quetiapine XR 400 mg/day for approximately 1 year. Comorbidities were hypertension treated with metoprolol, diabetes mellitus type 2 treated with metformin, and benign prostatic hyperplasia treated with silodosin...
December 2015: Drug Saf Case Rep
Nerusu Hari Babu
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Martin George, Mohammed Ghouse Shariff, Pramod Rao
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Maulee Hiromi Arambewela, Noel P Somasundaram, Chaminda Garusinghe
BACKGROUND: Hypernatremia is a frequent occurrence among hospitalized patients. Severe hypernatremia is associated with mortality rates of over 60 %. Extreme hypernatremia, defined as sodium levels >190 mmol/l, is a rare occurrence. The literature on electrocardiographic changes occurring with this degree of hypernatremia is extremely scarce. We report the case of an 11-year-old Sri Lankan girl who presented with sodium levels of 226 mmol/l following infusion with 3 % hypertonic saline who developed diffuse QT prolongation leading to fatal ventricular tachycardia...
October 1, 2016: Journal of Medical Case Reports
Steef Kurstjens, Jeroen De Baaij, Hacene Bouras, René Bindels, Cees J Tack, Joost Hoenderop
Background Hypomagnesemia (plasma magnesium (Mg2+) concentration <0.7 mmol/L) has been described in patients with type 2 diabetes. Polypharmacy is inevitable when treating a complex disease such as type 2 diabetes and could explain disturbances in the plasma Mg2+ concentration. In this study, we aimed to establish the extent of hypomagnesemia in a cohort of type 2 diabetes patients and to identify determinants of plasma Mg2+ levels. Methods Patient data and samples of 395 type 2 diabetes patients were investigated...
October 5, 2016: European Journal of Endocrinology
Nurul Afifah Mohd Salleh, Sabariah Ismail, Mohd Rohaimi Ab Halim
BACKGROUND: Curcuma xanthorrhiza is a native Indonesian plant and traditionally utilized for a range of illness including liver damage, hypertension, diabetes, and cancer. OBJECTIVE: The study determined the effects of C. xanthorrhiza extracts (ethanol and aqueous) and their constituents (curcumene and xanthorrhizol) on UDP-glucuronosyltransferase (UGT) and glutathione transferase (GST) activities. MATERIALS AND METHODS: The inhibition studies were evaluated both in rat liver microsomes and in human recombinant UGT1A1 and UGT2B7 enzymes...
October 2016: Pharmacognosy Research
Yusuke Sakaguchi, Takayuki Hamano, Chikako Nakano, Yoshitsugu Obi, Isao Matsui, Yasuo Kusunoki, Daisuke Mori, Tatsufumi Oka, Nobuhiro Hashimoto, Yoshitsugu Takabatake, Atsushi Takahashi, Jun-Ya Kaimori, Toshiki Moriyama, Ryohei Yamamoto, Masaru Horio, Ken Sugimoto, Koichi Yamamoto, Hiromi Rakugi, Yoshitaka Isaka
BACKGROUND: The Agatston score, commonly used to quantify coronary artery calcification (CAC), is determined by the plaque area and density. Despite an excellent predictability of the Agatston score for cardiovascular events, the density of CAC has never been studied in patients with pre-dialysis chronic kidney disease (CKD). This study aimed to analyze the CAC density and its association with serum mineral levels in CKD. METHODS: We enrolled patients with pre-dialysis CKD who had diabetes mellitus, prior cardiovascular disease history, elevated low-density lipoprotein cholesterol levels, or smoking history...
2016: PloS One
Michael A Ulm, Catherine H Watson, Prethi Vaddadi, Jim Y Wan, Joseph T Santoso
OBJECTIVE: The aim of this study was to assess the incidence of and risk factors for hypomagnesemia in patients undergoing gynecologic surgery by a gynecologic oncologist. METHODS: A retrospective chart review was performed on all patients undergoing surgery for gynecologic pathology from July 2011 to July 2015 by a single surgeon. Demographic data, surgical indication, surgery performed, preoperative laboratory values, postoperative laboratory values, and medical history were examined...
September 2016: International Journal of Gynecological Cancer
Huilin Tang, Xi Zhang, Jingjing Zhang, Yufeng Li, Liana C Del Gobbo, Suodi Zhai, Yiqing Song
AIMS/HYPOTHESIS: By analysing available evidence from randomised controlled trials (RCTs), we aimed to examine whether and to what extent sodium-glucose cotransporter 2 (SGLT2) inhibitors affect serum electrolyte levels in type 2 diabetes patients. METHODS: We searched PubMed, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL) and up to 24 May 2016 for published RCTs of SGLT2 inhibitors that reported changes in serum electrolyte levels...
September 15, 2016: Diabetologia
Agnieszka Ścibior
Vanadium (V) and magnesium (Mg) arouse interest of many research centres worldwide. Many aspects of their action have already been recognized but some of them have not been fully elucidated yet. Relatively little is known about the mechanisms of absorption, transport, and excretion of V. There is also a lack of sufficient data about the most sensitive biomarkers of V toxicity and the mechanisms of its toxic action, which have not been fully explained yet. There is also a lack of comprehensive research on the consequences, character, and mechanisms of mutual interactions of V (which has strong pro-oxidant properties) with elements with an antioxidant potential such as Mg, the recognition of which, besides the cognitive value, may have great practical importance...
October 25, 2016: Chemico-biological Interactions
Abdulbari Bener, Abdulla O A A Al-Hamaq, Khalid Abdulhadi, Ahmed H Salahaldin, Loida Gansan
AIM: The aim of this study was to determine the prevalence of hearing loss and its association with type 2 diabetes mellitus (T2DM) in a highly endogamous population. DESIGN: This is a cross-sectional study. SETTING: The present study is carried out in Ear Nose Throat (ENT) and Endocrinology outpatient clinics of the Hamad General and Rumeilah Hospitals, Hamad Medical Corporation. SUBJECTS: All subjects aged between 20 and 59 years who visited the Endocrinology and ENT outpatient clinics of the Hamad Medical Corporation with hearing difficulty were included in this study during the period from January 2013 to July 2014...
September 5, 2016: Diabetes & Metabolic Syndrome
Chen Chu, Weijing Zhao, Yinan Zhang, Lu Li, Jingyi Lu, Lan Jiang, Congrong Wang, Weiping Jia
The aim of this study was to explore the relationship between serum magnesium and peripheral nerve function in patients with type 2 diabetes (T2DM). A total of 978 T2DM patients were included in the study. Patients were divided into tertiles according to serum magnesium concentration (low tertile: ≤0.85 mmol/L; medium tertile: 0.85 to 0.92 mmol/L; and high tertile: >0.92 mmol/L). All participants underwent nerve conduction (NC) studies. Composite z scores of conduction velocity, latency, and amplitude were constructed, respectively...
2016: Scientific Reports
Adriana González-Villalva, Laura Colín-Barenque, Patricia Bizarro-Nevares, Marcela Rojas-Lemus, Vianey Rodríguez-Lara, Isabel García-Pelaez, Martha Ustarroz-Cano, Nelly López-Valdez, Juan Carlos Albarrán-Alonso, Teresa I Fortoul
There are evidences of environmental pollution and health effects. Metals are pollutants implicated in systemic toxicity. One of the least studied effects, but which is currently becoming more important, is the effect of metals on glycemic control. Metals have been implicated as causes of chronic inflammation and oxidative stress and are associated to obesity, hyperglycemia and even diabetes. Arsenic, iron, mercury, lead, cadmium and nickel have been studied as a risk factor for hyperglycemia and diabetes. There is another group of metals that causes hypoglycemia such as vanadium, chromium, zinc and magnesium by different mechanisms...
September 2016: Environmental Toxicology and Pharmacology
Jun Lu, Yuying Gu, Meixiang Guo, Peihong Chen, Hongtao Wang, Xuemei Yu
Aim. To investigate the association between serum magnesium levels and microvascular complications among patients with diabetes. Methods. Patients with diabetes were recruited between April 2012 and January 2015. All patients received an assay of serum magnesium concentration, were screened for 24 h albumin excretion rate, and underwent nonmydriatic fundus photography. Albuminuria and retinopathy were defined accordingly. A total of 3,100 patients with normal serum magnesium levels were included in this study...
2016: Journal of Diabetes Research
Li Hao Richie Xu, Naim M Maalouf
BACKGROUND: Insulin may influence magnesium homeostasis through multiple mechanisms. Acutely, it stimulates the shift of magnesium from plasma into red blood cells and platelets, and in vitro, it stimulates the activity of the TRPM6 channel, a key regulator of renal magnesium reabsorption. We investigated the impact of hyperinsulinemia on magnesium handling in participants with a wide range of insulin sensitivity. METHOD: Forty-seven participants were recruited, including 34 nondiabetic controls and 13 with type 2 diabetes mellitus...
August 22, 2016: Diabetes/metabolism Research and Reviews
I M Talaat, A Nasr, A A Alsulaimani, H Alghamdi, K A Alswat, D M Almalki, A Abushouk, A M Saleh, G Allam
PURPOSE: Vitamin D may play a role in the pathogenesis of type 1 diabetes (T1D). The aim of the current study was to determine the possible association between 25-hydroxyvitamin D [25(OH)D] levels and circulating levels of type 1 and type 2 cytokines, as well as the pathophysiology of T1D in children. METHODS: A total of 250 T1D patients and 250 sex- and age-matched T1D-free controls were screened for 25(OH)D, hemoglobin A1c (HbA1c), type 1 and type 2 cytokines, C-reactive protein (CRP) and bone mineral metabolism, as well as antibodies against insulin, glutamic acid decarboxylase (anti-GAD 65) and islet cells...
August 19, 2016: Journal of Endocrinological Investigation
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