Ellinor Wisén, Andreas Kvarnström, Lena Sand-Bown, Magnus Rizell, Aldina Pivodic, Sven-Erik Ricksten, Kristina Svennerholm
INTRODUCTION: Liver resection carries a high risk for extensive bleeding and need for blood transfusions, which is associated with significant negative impact on outcome. In malignant disease, the most common indication for surgery, it also includes increased risk for recurrence of cancer. Argipressin decreases liver and portal blood flow and may have the potential to reduce bleeding during liver surgery, although this has not been explored. METHOD AND ANALYSIS: ARG-01 is a prospective, randomised, placebo-controlled, double-blinded study on 248 patients undergoing liver resection at Sahlgrenska University Hospital, Sweden...
August 24, 2023: BMJ Open