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https://www.readbyqxmd.com/read/27933290/validation-of-a-cochlear-implant-patient-specific-model-of-the-voltage-distribution-in-a-clinical-setting
#1
Waldo Nogueira, Daniel Schurzig, Andreas Büchner, Richard T Penninger, Waldemar Würfel
Cochlear Implants (CIs) are medical implantable devices that can restore the sense of hearing in people with profound hearing loss. Clinical trials assessing speech intelligibility in CI users have found large intersubject variability. One possibility to explain the variability is the individual differences in the interface created between electrodes of the CI and the auditory nerve. In order to understand the variability, models of the voltage distribution of the electrically stimulated cochlea may be useful...
2016: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/27929596/primary-solitary-intralabyrinthine-schwannoma-a-report-of-7-cases-and-a-review-of-the-literature
#2
Avi Shupak, Yehuda Holdstein, Margalit Kaminer, Itzhak Braverman
Intralabyrinthine schwannomas (ILSs) are uncommon benign tumors that originate in the Schwann cell sheath of the intralabyrinthine distal branches of the vestibulocochlear nerve. They have no initial involvement in the internal auditory canal, although that might develop later. These lesions can arise inside the cochlea, originate in the vestibule or, in rare cases, develop in the semicircular canals. From these sites, spread might take place via the anatomic connections between the perilymphatic spaces in the scala vestibuli and the anterior vestibule...
December 2016: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/27925583/modeling-electrode-place-discrimination-in-cochlear-implant-stimulation
#3
Xiao Gao, David Bruce Grayden, Mark D McDonnell
OBJECTIVE: By modeling the cochlear implant (CI) electrode-to-nerve interface and quantifying electrode discriminability in the model, we address the questions of how many individual channels can be distinguished by CI recipients and the extent to which performance might be improved by inserting electrodes deeper into the cochlea. METHOD: We adapt an artificial neural network to model electrode discrimination, as well as a commonly used psychophysical measure (four-interval forcedchoice) in CI stimulation and predict how well the locations of the stimulating electrodes can be inferred from simulated auditory nerve spiking patterns...
December 1, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/27923565/sound-generator-associated-with-the-counseling-in-the-treatment-of-tinnitus-evaluation-of-the-effectiveness
#4
Andressa Vital Rocha, Maria Fernanda Capoani Garcia Mondelli
INTRODUCTION: The relations between the tinnitus and the hearing loss are due to the sensory deprivation caused by hearing loss, since this is followed by the functional and structural alteration of the auditory system as a whole. The cochlear lesions are accompanied by a reduction in the activity of the cochlear nerve, and the neural activity keeps increased in mainly all the central auditory nervous system to compensate this deficit. OBJECTIVE: This study aimed to verify the effectiveness of the sound generator (SG) associated with the counseling in the treatment of the tinnitus in individuals with and without hearing loss regarding the improvement of the nuisance through Tinnitus Handicap Inventory (THI) and Visual Analogue Scale (VAS)...
November 11, 2016: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/27916698/cellular-mechanisms-of-noise-induced-hearing-loss
#5
Arwa Kurabi, Elizabeth M Keithley, Gary D Housley, Allen F Ryan, Ann C-Y Wong
Exposure to intense sound or noise can result in purely temporary threshold shift (TTS), or leave a residual permanent threshold shift (PTS) along with alterations in growth functions of auditory nerve output. Recent research has revealed a number of mechanisms that contribute to noise-induced hearing loss (NIHL). The principle cause of NIHL is damage to cochlear hair cells and associated synaptopathy. Contributions to TTS include reversible damage to hair cell (HC) stereocilia or synapses, while moderate TTS reflects protective purinergic hearing adaptation...
December 1, 2016: Hearing Research
https://www.readbyqxmd.com/read/27909101/changes-in-properties-of-auditory-nerve-synapses-following-conductive-hearing-loss
#6
Xiaowen Zhuang, Wei Sun, Matthew A Xu-Friedman
: Auditory activity plays an important role in the development of the auditory system. Decreased activity can result from conductive hearing loss (CHL) associated with otitis media, which may lead to long-term perceptual deficits. The effects of CHL have been mainly studied at later stages of the auditory pathway, but early stages remain less examined. However, changes in early stages could be important, because they would affect how information about sounds is conveyed to higher order areas for further processing and localization...
December 1, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27904821/auditory-brainstem-response-and-late-latency-response-in-individuals-with-tinnitus-having-normal-hearing
#7
Sreeraj Konadath, Puttabasappa Manjula
Tinnitus is a commonly encountered complaint in routine audiology practice. The pathophysiology and exact generation site of tinnitus is not precisely established. Auditory brainstem response (ABR) and late latency response (LLR) findings in individuals with tinnitus show mixed results in the literature. Majority of studies have focused on individuals having tinnitus with peripheral hearing loss. The present study explores ABR and LLR characteristics among tinnitus patients with normal audiometric presentation; with no direct indication of any cochlear lesion...
November 2016: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/27900916/electrically-evoked-compound-action-potentials-are-different-depending-on-the-site-of-cochlear-stimulation
#8
Paul van de Heyning, Santiago L Arauz, Marcus Atlas, Wolf-Dieter Baumgartner, Marco Caversaccio, Ronel Chester-Browne, Patricia Estienne, Javier Gavilan, Benoit Godey, Wolfgang Gstöttner, Demin Han, Rudolph Hagen, Martin Kompis, Vlad Kuzovkov, Luis Lassaletta, Franc Lefevre, Yongxin Li, Joachim Müller, Lorne Parnes, Andrea Kleine Punte, Christopher Raine, Gunesh Rajan, Adriana Rivas, José Antonio Rivas, Nicola Royle, Georg Sprinzl, Kurt Stephan, Adam Walkowiak, Yuri Yanov, Kim Zimmermann, Patrick Zorowka, Henryk Skarzynski
One of the many parameters that can affect cochlear implant (CI) users' performance is the site of presentation of electrical stimulation, from the CI, to the auditory nerve. Evoked compound action potential (ECAP) measurements are commonly used to verify nerve function by stimulating one electrode contact in the cochlea and recording the resulting action potentials on the other contacts of the electrode array. The present study aimed to determine if the ECAP amplitude differs between the apical, middle, and basal region of the cochlea, if double peak potentials were more likely in the apex than the basal region of the cochlea, and if there were differences in the ECAP threshold and recovery function across the cochlea...
November 30, 2016: Cochlear Implants International
https://www.readbyqxmd.com/read/27898606/facial-nerve-meningioma-a-cause-of-pediatric-facial-weakness
#9
Nicholas L Deep, Sharon H Gnagi, David F Carpentieri, P David Adelson, Peter A Weisskopf
OBJECTIVE: To present an unusual case of a temporal bone meningioma with intrafascicular spread throughout the temporal facial nerve from cerebellopontine angle (CPA) to stylomastoid foramen. PATIENT: Four-year-old female with progressive facial weakness and normal hearing. MAIN OUTCOME MEASURE: Clinical, radiological, and histopathological findings of temporal bone meningiomas. RESULTS: A patient presented with progressive facial weakness and normal hearing...
November 24, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27898605/initial-results-of-a-safety-and-feasibility-study-of-auditory-brainstem-implantation-in-congenitally-deaf-children
#10
Eric P Wilkinson, Laurie S Eisenberg, Mark D Krieger, Marc S Schwartz, Margaret Winter, Jamie L Glater, Amy S Martinez, Laurel M Fisher, Robert V Shannon
OBJECTIVE: To determine the safety and feasibility of the auditory brainstem implant (ABI) in congenitally deaf children with cochlear aplasia and/or cochlear nerve deficiency. STUDY DESIGN: Phase I feasibility clinical trial of surgery in 10 children, ages 2 to 5 years, over a 3-year period. SETTING: Tertiary children's hospital and university-based pediatric speech/language/hearing center. INTERVENTION(S): ABI implantation and postsurgical programming...
November 24, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27898033/towards-clinical-application-of-neurotrophic-factors-to-the-auditory-nerve-assessment-of-safety-and-efficacy-by-a-systematic-review-of-neurotrophic-treatments-in-humans
#11
REVIEW
Aren Bezdjian, Véronique J C Kraaijenga, Dyan Ramekers, Huib Versnel, Hans G X M Thomeer, Sjaak F L Klis, Wilko Grolman
Animal studies have evidenced protection of the auditory nerve by exogenous neurotrophic factors. In order to assess clinical applicability of neurotrophic treatment of the auditory nerve, the safety and efficacy of neurotrophic therapies in various human disorders were systematically reviewed. Outcomes of our literature search included disorder, neurotrophic factor, administration route, therapeutic outcome, and adverse event. From 2103 articles retrieved, 20 randomized controlled trials including 3974 patients were selected...
November 26, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27897128/defining-the-limits-of-endoscopic-access-to-internal-auditory-canal
#12
Adam Master, Mickie Hamiter, Maura Cosetti
OBJECTIVE: To quantify surgical access to the internal auditory canal (IAC) using an exclusively endoscopic transcanal approach (EETA) and investigate surgically relevant relationships with neurovascular and osseous landmarks of the temporal bone. MATERIALS AND METHODS: Anatomical dissection of two paired temporal bones and 15 unpaired temporal bones was performed using an exclusively endoscopic approach to IAC. The dissection proceeded until the cerebellopontine angle (CPA) could be accessed...
November 28, 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27895575/can-animal-models-contribute-to-understanding-tinnitus-heterogeneity-in-humans
#13
REVIEW
Jos J Eggermont
The brain activity of humans with tinnitus of various etiologies is typically studied with electro- and magneto-encephalography and functional magnetic resonance imaging-based imaging techniques. Consequently, they measure population responses and mostly from the neocortex. The latter also underlies changes in neural networks that may be attributed to tinnitus. However, factors not strictly related to tinnitus such as hearing loss and hyperacusis, as well as other co-occurring disorders play a prominent role in these changes...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27891421/imaging-modality-of-choice-for-pre-operative-cochlear-imaging-hrct-vs-mri-temporal-bone
#14
Poornima Digge, Rajendra N Solanki, Dipali C Shah, Rajesh Vishwakarma, Sandeep Kumar
INTRODUCTION: Congenital inner ear malformations occur as a result of the arrest or aberrance of inner ear development due to the heredity, gene mutation or other factors. Ever since the availability of cochlear implants, pre-operative evaluation by imaging of temporal bone has gained much attention. Precise selection of the candidate for cochlear implant dependent on preoperative radiological investigations. Only CT (Computed Tomography) and MRI (Magnetic Resonance Imaging) can provide a better picture of anatomy and pathology...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27890767/implications-of-vestibular-schwannoma-consistency-analysis-of-140-cases-regarding-radiological-and-clinical-features
#15
Ahmed R Rizk, Abbas Adam, Isabel Gugel, Jens Schittenhelm, Marcos Tatagiba, Florian H Ebner
OBJECTIVE: To evaluate the effects of vestibular schwannoma (VS) consistency on internal auditory canal (IAC) widening, MRI-appearance, presenting symptoms and facial nerve outcome. MATERIAL AND METHODS: We performed a retrospective analysis of 140 consecutive patients presenting with unilateral VS who underwent surgical treatment in our Department. Operative videos were analyzed, and the tumors were classified into soft and firm according to the resectability with the ultrasonic aspirator at 40% power...
November 24, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27888040/evidence-that-hidden-hearing-loss-underlies-amplitude-modulation-encoding-deficits-in-individuals-with-and-without-tinnitus
#16
Brandon T Paul, Ian C Bruce, Larry E Roberts
Damage to auditory nerve fibers that expresses with suprathreshold sounds but is hidden from the audiogram has been proposed to underlie deficits in temporal coding ability observed among individuals with otherwise normal hearing, and to be present in individuals experiencing chronic tinnitus with clinically normal audiograms. We tested whether these individuals may have hidden synaptic losses on auditory nerve fibers with low spontaneous rates of firing (low-SR fibers) that are important for coding suprathreshold sounds in noise while high-SR fibers determining threshold responses in quiet remain relatively unaffected...
November 23, 2016: Hearing Research
https://www.readbyqxmd.com/read/27881784/low-somatic-sodium-conductance-enhances-action-potential-precision-in-time-coding-auditory-neurons
#17
Yang Yang, Bina Ramamurthy, Andreas Neef, Matthew A Xu-Friedman
: Auditory nerve fibers encode sounds in the precise timing of action potentials (APs), which is used for such computations as sound localization. Timing information is relayed through several cell types in the auditory brainstem that share an unusual property: their APs are not overshooting, suggesting that the cells have very low somatic sodium conductance (gNa). However, it is not clear how gNa influences temporal precision. We addressed this by comparing bushy cells (BCs) in the mouse cochlear nucleus with T-stellate cells (SCs), which do have normal overshooting APs...
November 23, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27879487/electrocochleography-in-cochlear-implant-recipients-with-residual-hearing-comparison-with-audiometric-thresholds
#18
Kanthaiah Koka, Aniket A Saoji, Leonid M Litvak
OBJECTIVES: To determine whether electrocochleography (ECoG) thresholds, especially cochlear microphonic and auditory nerve neurophonic thresholds, measured using an intracochlear electrode, can be used to predict pure-tone audiometric thresholds following cochlear implantation in ears with residual hearing. DESIGN: Pure-tone audiometric thresholds and ECoG waveforms were measured at test frequencies from 125 to 4000 Hz in 21 Advanced Bionics cochlear implant recipients with residual hearing in the implanted ear...
November 22, 2016: Ear and Hearing
https://www.readbyqxmd.com/read/27867121/effect-of-direct-stimulation-of-the-cochleovestibular-nerve-on-tinnitus-a-long-term-follow-up-study
#19
Minke J C van den Berge, J Marc C van Dijk, Rolien H Free, Janke Stienstra, Pim van Dijk, Bernard F A M van der Laan
OBJECTIVE: Tinnitus is a common entity that may lead to severe impairment in quality of life. An adequate treatment modality for severe tinnitus is currently lacking. Neurostimulation of the auditory tract may serve as a promising adjunct in tinnitus treatment. The aim is to investigate the effect of direct stimulation on the cochleovestibular nerve for intractable tinnitus. METHODS: This study was conducted at the University Medical Center Groningen, The Netherlands...
November 17, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27864104/pharmacological-response-sensitization-in-nerve-cell-networks-exposed-to-the-antibiotic-gentamicin
#20
Kevin S Hamilton, Kamakshi V Gopal, Ernest J Moore, Guenter W Gross
Gentamicin is an aminoglycoside antibiotic that is used in clinical, organismic, and agricultural applications to combat gram-negative, aerobic bacteria. The clinical use of gentamicin is widely linked to various toxicities, but there is a void in our knowledge about the neuromodulatory or neurotoxicity effects of gentamicin. This investigation explored the electrophysiologic effects of gentamicin on GABAergic pharmacological profiles in spontaneously active neuronal networks in vitro derived from auditory cortices of E16 mouse embryos and grown on microelectrode arrays...
November 15, 2016: European Journal of Pharmacology
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