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MM Babu

Sanjay Khadgi, Babu Shrestha, Hamdy Ibrahim, Sunil Shrestha, Mohammed S ElSheemy, Ahmed M Al-Kandari
To evaluate safety and efficacy of minipercutaneous nephrolithotomy (Mini-PNL) in management of stones in different types of renal anomalies. Patients with stones ≥2 cm or SWL-resistant stones in anomalous-kidneys treated by Mini-PNL between March 2010 and September 2012 were included prospectively. Mini-PNL was done under regional anesthesia in prone position with fluoroscopic guidance through 18 Fr sheath using semirigid ureteroscope (8.5/11.5 Fr) and pneumatic lithotripter. All patients were followed-up for 2-3 years...
October 4, 2016: Urolithiasis
Eric M Sugihara, Seilesh C Babu, Dennis J Kitsko, Michael S Haupert, Prasad J Thottam
OBJECTIVE: To determine the pediatric incidence and association of superior semicircular canal dehiscence (SSCD) with inner ear (IE) anomalies. STUDY DESIGN: Retrospective chart review. SETTING: Two tertiary referral centers. PATIENTS: Children less than 18 years who received a 0.5 mm or less collimated computed tomography study including the temporal bones between 2010 and 2013 for reasons including, but not limited to, hearing loss, trauma, and infection...
October 2016: Otology & Neurotology
K Prakashini, Satish Babu, K V Rajgopal, K Raja Kokila
AIMS AND OBJECTIVES: To determine the overall performance of an existing CAD algorithm with thin-section computed tomography (CT) in the detection of pulmonary nodules and to evaluate detection sensitivity at a varying range of nodule density, size, and location. MATERIALS AND METHODS: A cross-sectional prospective study was conducted on 20 patients with 322 suspected nodules who underwent diagnostic chest imaging using 64-row multi-detector CT. The examinations were evaluated on reconstructed images of 1...
July 2016: Lung India: Official Organ of Indian Chest Society
Youyou Li, Leena P Bharath, Ying Qian, Ting Ruan, Pon Velayutham Anandh Babu, Richard S Bruno, J David Symons, Thunder Jalili
Endothelial dysfunction occurs when there are imbalances between factors that regulate the synthesis and degradation of nitric oxide (NO(•)), and has been reported in patients with hyperglycemia and insulin resistance. We reported that supplementation with γ-tocopherol (γ-T) in humans limits impairments in endothelial function otherwise induced by postprandial hyperglycemia. Given the rapid metabolism of γ-T into γ-carboxyethyl hydroxychroman (γ-CEHC), we hypothesized that the vasoprotective activities of γ-T could be attributed to its metabolite γ-CEHC...
July 27, 2016: Experimental Biology and Medicine
Johnathan R Lex, Babu Naidu
A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was 'In patients with resectable non-small-cell lung cancer, is video-assisted thoracoscopic segmentectomy an appropriate alternative to video-assisted thoracoscopic lobectomy?' Two hundred papers were found using the reported search, of which 8 represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated...
July 11, 2016: Interactive Cardiovascular and Thoracic Surgery
Vin Shen Ban, Jeffrey S Beecher, Christopher S Eddleman, Salah G Aoun, Kristopher Allen Lyon, Tarek Youssef El Ahmadieh, Cameron Michael McDougall, Babu Guai Welch, Joan Reisch, H Hunt Batjer, Duke S Samson, Jonathan A White
INTRODUCTION: Predicting outcome after aneurysmal rupture can be challenging. The Southwestern Aneurysm Severity Index (SASI) was developed to aid aneurysm treatment outcome prediction. In this introduction of SASI, we analyzed patients with ruptured aneurysms treated microsurgically. With the use of this cohort, each SASI element was evaluated to measure its value to the overall index. METHODS: Patients presenting to our institution with ruptured aneurysms from 2000 to 2014 treated with microsurgery were included...
August 2016: Neurosurgery
Sunitha Chandran, Suresh Babu S, Hari Krishnan Vs, H K Varma, Annie John
Excessive demineralization in osteoporotic bones impairs its self-regeneration potential following a defect/fracture and is of great concern among the aged population. In this context, implants with inherent osteogenic ability loaded with therapeutic ions like Strontium (Sr(2+)) may bring forth promising outcomes. Micro-granular Strontium incorporated Hydroxyapatite scaffolds have been synthesized and in vivo osteogenic efficacy was evaluated in a long-term osteoporosis-induced aged (LOA) rat model. Micro-granules with improved surface area are anticipated to resorb faster and together with the inherent bioactive properties of Hydroxyapatite with the leaching of Strontium ions from the scaffold, osteoporotic bone healing may be promoted...
May 9, 2016: Journal of Biomaterials Applications
Amol A Deshpande, P Madhavan, Girish R Deshpande, Ravi Kumar Chandel, Kaviraj M Yarbagi, Alok R Joshi, J Moses Babu, R Murali Krishna, I M Rao
Fondaparinux sodium is a synthetic low-molecular-weight heparin (LMWH). This medication is an anticoagulant or a blood thinner, prescribed for the treatment of pulmonary embolism and prevention and treatment of deep vein thrombosis. Its determination in the presence of related impurities was studied and validated by a novel ion-pair HPLC method. The separation of the drug and its degradation products was achieved with the polymer-based PLRPs column (250 mm × 4.6 mm; 5 μm) in gradient elution mode. The mixture of 100 mM n-hexylamine and 100 mM acetic acid in water was used as buffer solution...
2016: Scientia Pharmaceutica
Daniele Tosi, Paola Saccomandi, Emiliano Schena, Dinesh Babu Duraibabu, Sven Poeggel, Gabriel Leen, Elfed Lewis
We report the first-ever intra-tissue pressure measurement performed during 1064 nm laser ablation (LA) of an ex vivo porcine liver. Pressure detection has been performed with a biocompatible, all-glass, temperature-insensitive Extrinsic Fabry-Perot Interferometry (EFPI) miniature probe; the proposed methodology mimics in-vivo treatment. Four experiments have been performed, positioning the probe at different positions from the laser applicator tip (from 0.5 mm to 5 mm). Pressure levels increase during ablation time, and decrease with distance from applicator tip: the recorded peak parenchymal pressure levels range from 1...
2016: Sensors
Sathish Babu Munaga, Rajani Kumar Valluru, Phani Bhushana Reddy Bonga, V Sumathi Rao, Hemanth Kumar Sharma
A simple, selective, sensitive and high-throughput liquid chromatography-tandem mass spectrometry (LC-MS-MS) method has been developed and validated for the simultaneous quantification of simvastatin (SS), simvastatin acid (SSA, active metabolite of SS) and ezetimibe (EZM) in K2 EDTA containing human plasma, using simvastatin D6, simvastatin acid D3 and ezetimibe D4 as internal standards (ISTDs), respectively. A volume of plasma sample of only 400 µL was processed by the solid phase extraction technique; then 20 µL of processed sample was run on a Phenomenex, Kinetix XB C18, 150 × 4...
July 2016: Journal of Chromatographic Science
Kishore Kumar Katuri, Ankineedu Babu Dasari, Sruthi Kurapati, Narayana Rao Vinnakota, Appaiah Chowdary Bollepalli, Ravindranath Dhulipalla
AIM: Reducing the psychosocial stress by various methods can improve overall health, and yoga is now considered as an easily available alternative method. The present cross-sectional pilot study was conducted mainly to find the association of yoga practice with periodontal disease by measuring serum cortisol levels. MATERIALS AND METHODS: A total of 70 subjects with age range of 35-60 years suffering with chronic periodontitis were divided into group I (with stress), group II (without stress), and group III (practicing yoga)...
January 2016: Journal of International Society of Preventive & Community Dentistry
Ammi Reddy Pulagam, Giri Babu Kande, Venkata Krishna Rao Ede, Ramesh Babu Inampudi
Performing accurate and fully automated lung segmentation of high-resolution computed tomography (HRCT) images affected by dense abnormalities is a challenging problem. This paper presents a novel algorithm for automated segmentation of lungs based on modified convex hull algorithm and mathematical morphology techniques. Sixty randomly selected lung HRCT scans with different abnormalities are used to test the proposed algorithm, and experimental results show that the proposed approach can accurately segment the lungs even in the presence of disease patterns, with some limitations in the apices and bases of lungs...
August 2016: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
Lavanya Kakarla, Suresh Babu Katragadda, Mahendran Botlagunta
BACKGROUND: Cyperus scariosus (CS) R.Br and Cyperus rotundus (CR) L. belongs to Cyperaceae family which is well-reputed in the traditional systems of medicine. Although they grow in different agro-climatic conditions, they are often considered to be synonymous with each other. OBJECTIVE: The present study was aimed to systematically classify both the species CS and CR through their morphological features and chemical profiling using liquid chromatography-mass spectroscopy (LC-MS), gas chromatography-mass spectroscopy (GC-MS) and thin layer chromatography patterns of the rhizome extracts...
October 2015: Pharmacognosy Magazine
Karunakaran Kaviarasu, N Arunai Nambi Raj, K Krishna Murthy, A Ananda Giri Babu, Bhaskar Laxman Durga Prasad
The aim of this study was to examine the impact of dose rate on accuracy of intensity modulated radiation therapy (IMRT) plan delivery by comparing the gamma agreement between the calculated and measured portal doses by pretreatment quality assurance (QA) using electronic portal imaging device dosimetry and creating a workflow for the pretreatment IMRT QA at hospital levels. As the improvement in gamma agreement leads to increase in the quality of IMRT treatment delivery, gamma evaluation was carried out for the calculated and the measured portal images for the criteria of 3% dose difference and 3 mm distance-to-agreement (DTA)...
October 2015: Journal of Medical Physics
Ranjan Gupta, Babu Lal Kumawat, Preeti Paliwal, Radhika Tandon, Namrata Sharma, Seema Sen, Seema Kashyap, Tapas Chandra Nag, Rasik B Vajpayee, Arundhati Sharma
PURPOSE: Fuchs endothelial corneal dystrophy (FECD) results in loss of vision associated with progressive corneal edema and loss of corneal transparency. The aim of the study was to evaluate changes in ZEB1, COL8A2, SLC4A11, and TCF4 rs613872 and correlate them with clinical findings. METHODS: Eighty-two patients with clinically diagnosed FECD and 143 controls were recruited during the period 2007-2012. Clinical details, pedigree information up to three generations, and 5 ml of blood samples were collected...
2015: Molecular Vision
Nishu Sekar, Manju Nair, Glory Francis, Parvathy Raj Kongath, Sandhya Babu, Sudhakaran Raja, Abilash Valsala Gopalakrishnan
BACKGROUND: The polycystic ovary syndrome (PCOS), characterized by hyperandrogenism and chronic anovulation, is a common endocrine disorder in women. PCOS, which is associated with polycystic ovaries, hirsutism, obesity and insulin resistance, is a leading cause of female infertility. In this condition there is an imbalance in female sex hormones. All the sequelae symptoms of PCOS gradually lead to cancer in the course of time. It is heterogeneous disorder of unknown etiology so it is essential to find the exact cause...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
Ragesh Babu Thandassery, Manik Sharma, Anil K John, Khalid Mohsin Al-Ejji, Hamidulla Wani, Khaleel Sultan, Muneera Al-Mohannadi, Rafie Yakoob, Moutaz Derbala, Nazeeh Al-Dweik, Muhammed Tariq Butt, Saad Rashid Al-Kaabi
BACKGROUND/AIMS: To evaluate the ability of the recently proposed albumin, international normalized ratio (INR), mental status, systolic blood pressure, age >65 years (AIMS65) score to predict mortality in patients with acute upper gastrointestinal bleeding (UGIB). METHODS: AIMS65 scores were calculated in 251 consecutive patients presenting with acute UGIB by allotting 1 point each for albumin level <30 g/L, INR >1.5, alteration in mental status, systolic blood pressure ≤90 mm Hg, and age ≥65 years...
September 2015: Clinical Endoscopy
S Ebenezer Suman Babu, I Rabi Raja Singh, C G Poornima, B Paul Ravindran
INTRODUCTION: The principle of Fricke gel dosimeter is the oxidation of ferric ions on exposure to radiation. The major limitation in this dosimeter is the post-irradiation diffusion of ferric ions leading to degradation of spatial dose information. AIMS AND OBJECTIVES: The primary objective of this study is to reduce diffusion of ferric ions post-irradiation and enhance the spatial stability of the dose for an acceptable period, within which it can be read out...
July 2015: Journal of Cancer Research and Therapeutics
Sarath Babu Devarakonda, Boochi Babu Mannuva, Rajasekhar Durgaprasad, Vanajakshamma Velam, Vidya Sagar Akula, Latheef Kasala
INTRODUCTION: Percutaneous transvenous mitral commissurotomy (PTMC) is a safe and effective procedure for relief of severe mitral stenosis. PTMC is being done widely and many transseptal procedures requiring large diameter catheters, sheaths are becoming popular. The knowledge of iatrogenic atrial septal defect (iASD) is vital. This study assessed the use of real-time 3D echocardiography (RT3DE) and incidence of iASD in a cohort of patients undergoing transseptal catheterization during PTMC...
2015: Journal of Cardiovascular and Thoracic Research
Manisha Bhateria, Rachumallu Ramakrishna, Dora Babu Pakala, Rabi Sankar Bhatta
Recently, a fixed dose combination (FDC) of memantine (MM) and donepezil (DPZ) has been approved for the treatment of Alzheimer's disease (AD). In the present work, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous determination of MM and DPZ was developed and validated in rat plasma over the linearity range of 0.2-400ng/mL using amantadine (AM) as an internal standard. Both the analytes and IS were extracted using one step liquid-liquid extraction procedure. The analytes were separated on C18 reversed phase column with mobile phase consisting of a mixture of methanol and 10mM ammonium acetate, pH 5 (92:8 v/v) at a flow rate of 0...
September 15, 2015: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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