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https://www.readbyqxmd.com/read/29681407/circulating-metabolites-of-strawberry-mediate-reductions-in-vascular-inflammation-and-endothelial-dysfunction-in-db-db-mice
#1
Chrissa Petersen, Divya Bharat, Brett Ronald Cutler, Samira Gholami, Christopher Denetso, Jennifer Ellen Mueller, Jae Min Cho, Ji-Seok Kim, J David Symons, Pon Velayutham Anandh Babu
BACKGROUND: Cardiovascular disease is 2-4-fold more prevalent in patients with diabetes. Human studies support the cardiovascular benefits of strawberry consumption but the effects of strawberry on diabetic vasculature are unknown. We tested the hypothesis that dietary strawberry supplementation attenuates vascular inflammation and dysfunction in diabetic mice. METHODS: Seven-week-old diabetic db/db mice that consumed standard diet (db/db) or diet supplemented with 2...
April 12, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29680633/multiplex-tandem-mass-spectrometry-assay-for-newborn-screening-of-x-linked-adrenoleukodystrophy-biotinidase-deficiency-and-galactosemia-with-flexibility-to-assay-other-enzyme-assays-and-biomarkers
#2
Xinying Hong, Arun Babu Kumar, C Ronald Scott, Michael H Gelb
All States screen for biotinidase deficiency and galactosemia, and X-linked adrenoleukodystrophy (X-ALD) has recently been added to the Recommended Uniform Screening Panel (RUSP).We sought to consolidate these tests by combining them into a single multiplex tandem mass spectrometry assay as well as to improve the current protocol for newborn screening of galactosemia.A 3 mm punch of a dried blood spot (DBS) was extracted with organic solvent for analysis of the C26:0-lysophosphatidylcholine biomarker for X-ALD...
March 29, 2018: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29508275/eadsg-guidelines-insulin-therapy-in-diabetes
#3
Bahendeka Silver, Kaushik Ramaiya, Swai Babu Andrew, Otieno Fredrick, Sarita Bajaj, Sanjay Kalra, Bavuma M Charlotte, Karigire Claudine, Anthony Makhoba
A diagnosis of diabetes or hyperglycemia should be confirmed prior to ordering, dispensing, or administering insulin (A). Insulin is the primary treatment in all patients with type 1 diabetes mellitus (T1DM) (A). Typically, patients with T1DM will require initiation with multiple daily injections at the time of diagnosis. This is usually short-acting insulin or rapid-acting insulin analogue given 0 to 15 min before meals together with one or more daily separate injections of intermediate or long-acting insulin...
April 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29503945/atypical-tolosa-hunt-syndrome-with-bilateral-sclerokeratitis-and-optic-atrophy-in-takayasu-s-arteritis
#4
Kalpana Babu, Deepika C Parameswarappa
Purpose: We report an interesting case of atypical Tolosa Hunt syndrome with bilateral Sclerokeratitis and optic atrophy in a patient with Takayasu's arteritis. Observations: A 31-year- old lady presented with severe retroorbital pain in the right eye and right sided headache of 2 weeks duration. She had a history of 6th and 7th nerve palsies which improved with oral corticosteroids. Her BCVA was no perception of light in OD and 6/6 in OS. Slitlamp examination showed bilateral old sclerokeratitis and fundus examination showed bilateral optic atrophy...
April 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29498569/fifty-shades-of-gradients-does-the-pressure-gradient-in-venous-sinus-stenting-for-idiopathic-intracranial-hypertension-matter-a-systematic-review
#5
Cameron M McDougall, Vin Shen Ban, Jeffrey Beecher, Lee Pride, Babu G Welch
OBJECTIVE The role of venous sinus stenting (VSS) for idiopathic intracranial hypertension (IIH) is not well understood. The aim of this systematic review is to attempt to identify subsets of patients with IIH who will benefit from VSS based on the pressure gradients of their venous sinus stenosis. METHODS MEDLINE/PubMed was searched for studies reporting venous pressure gradients across the stenotic segment of the venous sinus, pre- and post-stent pressure gradients, and clinical outcomes after VSS. Findings are reported according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines...
March 2, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29478029/treatment-of-blood-blister-aneurysms-of-the-internal-carotid-artery-with-flow-diversion
#6
Maxim Mokin, Angel Chinea, Christopher T Primiani, Zeguang Ren, Peter Kan, Visish M Srinivasan, Ricardo Hanel, Pedro Aguilar-Salinas, Aquilla S Turk, Raymond D Turner, M Imran Chaudry, Andrew J Ringer, Babu G Welch, Vitor Mendes Pereira, Leonardo Renieri, Mariangela Piano, Lucas Elijovich, Adam S Arthur, Ahmed Cheema, Demetrius Klee Lopes, Ahmed Saied, Blaise W Baxter, Harris Hawk, Ajit S Puri, Ajay K Wakhloo, Hussain Shallwani, Elad I Levy, Adnan H Siddiqui, Guilherme Dabus, Italo Linfante
BACKGROUND: Blood blister aneurysms (BBA) are a rare subset of intracranial aneurysms that represent a therapeutic challenge from both a surgical and endovascular perspective. OBJECTIVE: To report multicenter experience with flow diversion exclusively for BBA, located at non-branching segments along the anteromedial wall of the supraclinoidal internal carotid artery (ICA). METHODS: Consecutive cases of BBA located at non-branching segments along the anteromedial wall of the supraclinoidal ICA treated with flow diversion were included in the final analysis...
February 24, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29442791/fabrication-of-highly-sensitive-nonenzymatic-electrochemical-h%C3%A2-o%C3%A2-sensor-based-on-pt-nanoparticles-anchored-reduced-graphene-oxide
#7
Keerthy Dhara, T Ramachandran, Bipin G Nair, T G Satheesh Babu
A highly sensitive nonenzymatic hydrogen peroxide (H2O2) sensor was fabricated using platinum nanoparticles decorated reduced graphene oxide (Pt/rGO) nanocomposite. The Pt/rGO nanocomposite was prepared by single-step chemical reduction method. Nanocomposite was characterized by various analytical techniques including Raman spectroscopy, X-ray diffraction, field emission scanning electron microscope and high-resolution transmission electron microscopy. Screen printed electrodes (SPEs) were fabricated and the nanocomposite was cast on the working area of the SPE...
June 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29404029/development-and-validation-of-a-stability-indicating-rp-hplc-method-for-estimation-of-atazanavir-sulfate-in-bulk
#8
S Dey, S Subhasis Patro, N Suresh Babu, P N Murthy, S K Panda
A stability-indicating reverse phase-high performance liquid chromatography (RP-HPLC) method was developed and validated for the determination of atazanavir sulfate in tablet dosage forms using C18 column Phenomenix (250 mm×4.6 mm, 5 μm) with a mobile phase consisting of 900 mL of HPLC grade methanol and 100 mL of water of HPLC grade. The pH was adjusted to 3.55 with acetic acid. The mobile phase was sonicated for 10 min and filtered through a 0.45 μm membrane filter at a flow rate of 0.5 mL/min...
April 2017: Journal of Pharmaceutical Analysis
https://www.readbyqxmd.com/read/29209978/bioengineered-silver-nanoparticles-as-potent-anti-corrosive-inhibitor-for-mild-steel-in-cooling-towers
#9
Jayaraman Narenkumar, Punniyakotti Parthipan, Jagannathan Madhavan, Kadarkarai Murugan, Sreekar Babu Marpu, Anil Kumar Suresh, Aruliah Rajasekar
Silver nanoparticle-aided enhancement in the anti-corrosion potential and stability of plant extract as ecologically benign alternative for microbially induced corrosion treatment is demonstrated. Bioengineered silver nanoparticles (AgNPs) surface functionalized with plant extract material (proteinacious) was generated in vitro in a test tube by treating ionic AgNO3 with the leaf extract of Azadirachta indica that acted as dual reducing as well as stabilizing agent. Purity and crystallinity of the AgNPs, along with physical and surface characterizations, were evaluated by performing transmission electron microscopy, Fourier transform infrared spectroscopy, energy dispersive x-ray spectra, single-area electron diffractions, zeta potential, and dynamic light scattering measurements...
February 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29199718/multiple-myeloma-experience-of-an-institute-in-limited-resource-setting
#10
Linu Abraham Jacob, M C Suresh Babu, K C Lakshmaiah, K Govind Babu, D Lokanatha, L K Rajeev, K N Lokesh, A H Rudresha, Ankit Agarwal, Sunny Garg
INTRODUCTION: Multiple myeloma (MM) is a plasma cell dyscrasias and an incurable clonal B-cell malignancy, with an annual incidence of 1% of all malignancies. The mainstay of treatment of myeloma is induction treatment followed by consolidation with autologous stem cell transplant (ASCT). However, still in a developing country like India where affordability is a major hurdle for health care, a number of MM patients are not able to undergo ASCT. AIM: To study the epidemiological features and outcome of MM patients treated in a limited resource setting...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29184010/delayed-massive-haemothorax-10-days-following-percutaneous-nephrolithotomy
#11
Sanjay Sinha, Ramesh G Babu, Mallikarjun S Rao
A 56-year-old man presented with massive right haemothorax 10 days following percutaneous nephrolithotomy (PCNL) for complex, large-bulk, right renal stones. Antiplatelet medication started following coronary stenting 7 months ago was stopped 5 days prior and resumed 2 days following surgery. Stones were cleared through two tracts, one supracostal, with placement of ureteral stent but no nephrostomy. He was discharged the next day with an unremarkable chest X-ray. He developed cough and fever after 1 week...
November 28, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29099441/mastoid-and-inner-ear-measurements-in-patients-with-meni%C3%A3-re-s-disease
#12
Eric M Sugihara, Alexander L Marinica, Nathan D Vandjelovic, Benjamin M Kelley, Said S Sana, Nicholas E Starkey, Seilesh C Babu
OBJECTIVE: To determine the relationship between radiographic temporal bone anatomy of patients with Menière's disease in medically and surgically managed populations versus controls. STUDY DESIGN: Retrospective chart review. SETTING: Two tertiary referral centers. PATIENTS: Adults older than 18 years with Menière's disease treated with endolymphatic sac decompression (ESD) or medical management (non-ESD) versus controls...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28974855/a-hybrid-conformal-planning-technique-with-solitary-dynamic-portal-for-postmastectomy-radiotherapy-with-regional-nodes
#13
K Mohamathu Rafic, B S Timothy Peace, S Ebenezer Suman Babu, I Rabi Raja Singh
PURPOSE: This study focuses on incorporation of a solitary dynamic portal (SDP) in conformal planning for postmastectomy radiotherapy (PMRT) with nodal regions with an intention to overcome the treatment planning limitations imposed by conventional techniques. MATERIALS AND METHODS: Twenty-four patients who underwent surgical mastectomy followed by PMRT were included in this study. Initially, a treatment plan comprising tangential beams fitted to beam's-eye-view (BEV) of chest wall (CW) and a direct anterior field fitted to BEV of nodal region, both sharing a single isocenter was generated using Eclipse treatment planning system...
July 2017: Journal of Medical Physics
https://www.readbyqxmd.com/read/28969273/evaluating-the-correlation-between-anteroposterior-and-mediolateral-compensatory-curves-and-their-influence-on-dentoskeletal-morphology-an-in-vitro-cbct-study
#14
K Suresh Babu, A Nanda Kumar, Pradeep Babu Kommi, P Hari Krishnan, M Senthil Kumar, R Senkutvan Sabapathy, V Vijay Kumar
INTRODUCTION: To date, many orthodontist corrects malocclusion based on patients aesthetic concern and fails to correct the compensatory curves. This scenario is due to less insight on understanding relationship of compensatory curves and its correlation in treatment prognosis. AIM: The purpose of this study was to evaluate the correlation between the curve of Spee, curve of Monson and curve of Wilson, their influence on dentoskeletal morphology and their contribution to occlusal stability...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28892039/metabolites-of-flavonoid-compounds-preserve-indices-of-endothelial-cell-nitric-oxide-bioavailability-under-glucotoxic-conditions
#15
Y Qian, P V A Babu, J D Symons, T Jalili
We hypothesized that metabolites of dietary flavonoids attenuate impairments in nitric oxide (NO) bioavailability evoked by glucotoxic conditions mimicking Type 1 or 2 diabetes. To test this, human aortic endothelial cells were treated with either vehicle control, quercetin-3-O-glucoronide, piceatannol or 3-(3-hydroxyphenyl)propionoic acid for 24 h. These are metabolites of quercetin, resveratrol and proanthocyanidin, respectively. Next, cells were exposed to control (5 mM) or high (25 mM) glucose conditions for 48 h, followed by insulin treatment (100 nM, 10 min) to stimulate NO production...
September 11, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/28844754/the-role-of-preoperative-intra-muscular-testosterone-in-improving-functional-and-cosmetic-outcomes-following-hypospadias-repair-a-prospective-randomized-study
#16
Ramesh Babu, Sibi Chakravarthi
BACKGROUND: There are very few well-designed studies on the role of preoperative testosterone in hypospadias repair. The aims of the current study are to ascertain the efficacy of intramuscular testosterone in increasing the glans width, reducing the complications and improving the functional and cosmetic outcomes. MATERIALS AND METHODS: Between January 2013 and December 2016, a total of 200 patients with distal hypospadias were recruited to this prospective randomized study...
February 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28827974/ex-vivo-antispasmodic-activity-of-aqueous-extract-of-flowers-of-muntingia-calabura-linn-on-excised-rabbit-s-jejunum
#17
Kannan Vadivel, Gollapudi Sandeep Kumar, Sitty Manohar Babu
OBJECTIVE: The present study has been undertaken with the main objective of evaluating the aqueous extract of flowers of Muntingia calabura for antispasmodic activity on isolated rabbit's jejunum. MATERIALS AND METHODS: The study was carried out on isolated rabbit's jejunum preparations. The aqueous extract of flowers of M. calabura was applied in different doses by cumulative manner without washing the tissue. Spontaneous contractions abolished by the extract were recorded...
July 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28822029/gene-structure-and-comparative-and-phylogenetic-analyses-of-catla-catla-cyp1a-full-length-cdna-and-its-responsiveness-to-benzo-a-pyrene-and-copper-sulphate-at-early-developmental-stages
#18
Kavita Kumari, Gireesh-Babu Pathakota, Shivendra Kumar, Gopal Krishna
In the present study, full-length CYP1A cDNA from Catla catla (Catla) has been identified, and its real-time quantitative reverse transcription PCR (qRT-PCR) expression has been evaluated in different tissues, developmental stages (0, 3, 6, 12 and 24 h and 5, 7 and 9 days post-fertilization) and copper sulphate and benzo(a)pyrene (BaP)-treated 5-day post-fertilization (dpf) larvae (6 to 6.5 mm). Various structural, comparative and phylogenetic analyses of the deduced amino acid sequence revealed that the identified gene of Catla belongs to the CYP1A1 subfamily...
February 2018: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28820741/electromagnetic-and-optical-characteristics-of-nb-5-doped-double-crossover-and-salmon-dna-thin-films
#19
Sekhar Babu Mitta, Sreekantha Reddy Dugasani, Soon-Gil Jung, Srivithya Vellampatti, Tuson Park, Sung Ha Park
We report the fabrication and physical characteristics of niobium ion (Nb(5+))-doped double-crossover DNA (DX-DNA) and salmon DNA (SDNA) thin films. Different concentrations of Nb(5+) ([Nb(5+)]) are coordinated into the DNA molecules, and the thin films are fabricated via substrate-assisted growth (DX-DNA) and drop-casting (SDNA) on oxygen plasma treated substrates. We conducted atomic force microscopy to estimate the optimum concentration of Nb(5+) ([Nb(5+)]O = 0.08 mM) in Nb(5+)-doped DX-DNA thin films, up to which the DX-DNA lattices maintain their structures without deformation...
August 18, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28658906/the-effect-of-cavity-design-on-fracture-resistance-and-failure-pattern-in-monolithic-zirconia-partial-coverage-restorations-an-in-vitro-study
#20
Madhavareddy Sri Harsha, Mynampati Praffulla, Mandava Ramesh Babu, Gudugunta Leneena, Tejavath Sai Krishna, G Divya
INTRODUCTION: Cavity preparations of posterior teeth have been frequently associated with decreased fracture strength of the teeth. Choosing the correct indirect restoration and the cavity design when restoring the posterior teeth i.e., premolars was difficult as it involves aesthetic, biomechanical and anatomical considerations. AIM: To evaluate the fracture resistance and failure pattern of three different cavity designs restored with monolithic zirconia. MATERIALS AND METHODS: Human maxillary premolars atraumatically extracted for orthodontic reasons were chosen...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
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