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MM Babu

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https://www.readbyqxmd.com/read/29099441/mastoid-and-inner-ear-measurements-in-patients-with-meni%C3%A3-re-s-disease
#1
Eric M Sugihara, Alexander L Marinica, Nathan D Vandjelovic, Benjamin M Kelley, Said S Sana, Nicholas E Starkey, Seilesh C Babu
OBJECTIVE: To determine the relationship between radiographic temporal bone anatomy of patients with Menière's disease in medically and surgically managed populations versus controls. STUDY DESIGN: Retrospective chart review. SETTING: Two tertiary referral centers. PATIENTS: Adults older than 18 years with Menière's disease treated with endolymphatic sac decompression (ESD) or medical management (non-ESD) versus controls...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28974855/a-hybrid-conformal-planning-technique-with-solitary-dynamic-portal-for-postmastectomy-radiotherapy-with-regional-nodes
#2
K Mohamathu Rafic, B S Timothy Peace, S Ebenezer Suman Babu, I Rabi Raja Singh
PURPOSE: This study focuses on incorporation of a solitary dynamic portal (SDP) in conformal planning for postmastectomy radiotherapy (PMRT) with nodal regions with an intention to overcome the treatment planning limitations imposed by conventional techniques. MATERIALS AND METHODS: Twenty-four patients who underwent surgical mastectomy followed by PMRT were included in this study. Initially, a treatment plan comprising tangential beams fitted to beam's-eye-view (BEV) of chest wall (CW) and a direct anterior field fitted to BEV of nodal region, both sharing a single isocenter was generated using Eclipse treatment planning system...
July 2017: Journal of Medical Physics
https://www.readbyqxmd.com/read/28969273/evaluating-the-correlation-between-anteroposterior-and-mediolateral-compensatory-curves-and-their-influence-on-dentoskeletal-morphology-an-in-vitro-cbct-study
#3
K Suresh Babu, A Nanda Kumar, Pradeep Babu Kommi, P Hari Krishnan, M Senthil Kumar, R Senkutvan Sabapathy, V Vijay Kumar
INTRODUCTION: To date, many orthodontist corrects malocclusion based on patients aesthetic concern and fails to correct the compensatory curves. This scenario is due to less insight on understanding relationship of compensatory curves and its correlation in treatment prognosis. AIM: The purpose of this study was to evaluate the correlation between the curve of Spee, curve of Monson and curve of Wilson, their influence on dentoskeletal morphology and their contribution to occlusal stability...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28892039/metabolites-of-flavonoid-compounds-preserve-indices-of-endothelial-cell-nitric-oxide-bioavailability-under-glucotoxic-conditions
#4
Y Qian, P V A Babu, J D Symons, T Jalili
We hypothesized that metabolites of dietary flavonoids attenuate impairments in nitric oxide (NO) bioavailability evoked by glucotoxic conditions mimicking Type 1 or 2 diabetes. To test this, human aortic endothelial cells were treated with either vehicle control, quercetin-3-O-glucoronide, piceatannol or 3-(3-hydroxyphenyl)propionoic acid for 24 h. These are metabolites of quercetin, resveratrol and proanthocyanidin, respectively. Next, cells were exposed to control (5 mM) or high (25 mM) glucose conditions for 48 h, followed by insulin treatment (100 nM, 10 min) to stimulate NO production...
September 11, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/28844754/the-role-of-preoperative-intra-muscular-testosterone-in-improving-functional-and-cosmetic-outcomes-following-hypospadias-repair-a-prospective-randomized-study
#5
Ramesh Babu, Sibi Chakravarthi
BACKGROUND: There are very few well-designed studies on the role of preoperative testosterone in hypospadias repair. The aims of the current study are to ascertain the efficacy of intramuscular testosterone in increasing the glans width, reducing the complications and improving the functional and cosmetic outcomes. MATERIALS AND METHODS: Between January 2013 and December 2016, a total of 200 patients with distal hypospadias were recruited to this prospective randomized study...
August 12, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28827974/ex-vivo-antispasmodic-activity-of-aqueous-extract-of-flowers-of-muntingia-calabura-linn-on-excised-rabbit-s-jejunum
#6
Kannan Vadivel, Gollapudi Sandeep Kumar, Sitty Manohar Babu
OBJECTIVE: The present study has been undertaken with the main objective of evaluating the aqueous extract of flowers of Muntingia calabura for antispasmodic activity on isolated rabbit's jejunum. MATERIALS AND METHODS: The study was carried out on isolated rabbit's jejunum preparations. The aqueous extract of flowers of M. calabura was applied in different doses by cumulative manner without washing the tissue. Spontaneous contractions abolished by the extract were recorded...
July 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28822029/gene-structure-and-comparative-and-phylogenetic-analyses-of-catla-catla-cyp1a-full-length-cdna-and-its-responsiveness-to-benzo-a-pyrene-and-copper-sulphate-at-early-developmental-stages
#7
Kavita Kumari, Gireesh-Babu Pathakota, Shivendra Kumar, Gopal Krishna
In the present study, full-length CYP1A cDNA from Catla catla (Catla) has been identified, and its real-time quantitative reverse transcription PCR (qRT-PCR) expression has been evaluated in different tissues, developmental stages (0, 3, 6, 12 and 24 h and 5, 7 and 9 days post-fertilization) and copper sulphate and benzo(a)pyrene (BaP)-treated 5-day post-fertilization (dpf) larvae (6 to 6.5 mm). Various structural, comparative and phylogenetic analyses of the deduced amino acid sequence revealed that the identified gene of Catla belongs to the CYP1A1 subfamily...
August 19, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28820741/electromagnetic-and-optical-characteristics-of-nb-5-doped-double-crossover-and-salmon-dna-thin-films
#8
Sekhar Babu Mitta, Sreekantha Reddy Dugasani, Soon-Gil Jung, Srivithya Vellampatti, Tuson Park, Sung Ha Park
We report the fabrication and physical characteristics of niobium ion (Nb(5+))-doped double-crossover DNA (DX-DNA) and salmon DNA (SDNA) thin films. Different concentrations of Nb(5+) ([Nb(5+)]) are coordinated into the DNA molecules, and the thin films are fabricated via substrate-assisted growth (DX-DNA) and drop-casting (SDNA) on oxygen plasma treated substrates. We conducted atomic force microscopy to estimate the optimum concentration of Nb(5+) ([Nb(5+)]O = 0.08 mM) in Nb(5+)-doped DX-DNA thin films, up to which the DX-DNA lattices maintain their structures without deformation...
August 18, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28658906/the-effect-of-cavity-design-on-fracture-resistance-and-failure-pattern-in-monolithic-zirconia-partial-coverage-restorations-an-in-vitro-study
#9
Madhavareddy Sri Harsha, Mynampati Praffulla, Mandava Ramesh Babu, Gudugunta Leneena, Tejavath Sai Krishna, G Divya
INTRODUCTION: Cavity preparations of posterior teeth have been frequently associated with decreased fracture strength of the teeth. Choosing the correct indirect restoration and the cavity design when restoring the posterior teeth i.e., premolars was difficult as it involves aesthetic, biomechanical and anatomical considerations. AIM: To evaluate the fracture resistance and failure pattern of three different cavity designs restored with monolithic zirconia. MATERIALS AND METHODS: Human maxillary premolars atraumatically extracted for orthodontic reasons were chosen...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28634232/the-phosphocarrier-protein-hpr-of-the-bacterial-phosphotransferase-system-globally-regulates-energy-metabolism-by-directly-interacting-with-multiple-enzymes-in-escherichia-coli
#10
Irina A Rodionova, Zhongge Zhang, Jitender Mehla, Norman Goodacre, Mohan Babu, Andrew Emili, Peter Uetz, Milton H Saier
The histidine-phosphorylatable phosphocarrier protein (HPr) is an essential component of the sugar-transporting phosphotransferase system (PTS) in many bacteria. Recent interactome findings suggested that HPr interacts with several carbohydrate-metabolizing enzymes, but whether HPr plays a regulatory role was unclear. Here, we provide evidence that HPr interacts with a large number of proteins in Escherichia coli We demonstrate HPr-dependent allosteric regulation of the activities of pyruvate kinase (PykF, but not PykA), phosphofructokinase (PfkB, but not PfkA), glucosamine-6-phosphate deaminase (NagB), and adenylate kinase (Adk)...
August 25, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28546470/ocular-changes-over-60-minutes-in-supine-and-prone-postures
#11
Allison P Anderson, Gautam Babu, Jacob G Swan, Scott D Phillips, Darin A Knaus, Christine M Toutain-Kidd, Michael E Zegans, Abigail M Fellows, Jiang Gui, Jay C Buckey
Some astronauts are returning from long duration spaceflight with structural ocular and visual changes. We investigated both the transient and sustained effects of changes in the direction of the gravity vector acting on the eye using changes in body posture. Intraocular pressure (IOP-Perkins tonometer), ocular geometry (axial length, corneal thickness, and aqueous depth-noncontact biometer), and the choroidal (volume and subfoveal thickness optical coherence tomography) was measured in 10 subjects (5M, 5F)...
May 25, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28501960/a-modified-minimally-invasive-technique-for-intra-articular-displaced-calcaneal-fractures-fixed-by-transverse-and-axial-screws
#12
K C Kapil Mani, Parimal Acharya, R C Dirgha Raj, Bandhu Ram Pangeni, Arun Sigdel, Suman Babu Marahatta
The management of displaced, intra-articular calcaneal fracture represents a surgical challenge to even an experienced orthopedic surgeon. Plate osteosynthesis using an extended lateral approach is complicated by soft tissue problems, while those treated by closed reduction and percutaneous pinning cannot address all the intra-articular fragments sufficiently. The objective of our study is to evaluate restoration of subtalar joint and long-term functional outcomes in intra-articular displaced calcaneal fractures treated with transverse subcondral screws through a small incision on lateral aspect of calcaneus and percutaneously placed axial screws through the calcaneal tuberosity...
May 13, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28360469/myelomatous-pleural-effusion-a-rare-case-entity-reported-from-a-tertiary-care-cancer-center-in-south-india
#13
Govind K Babu, Smitha C Saldanha, K N Lokesh, M C Suresh Babu, Akkamaha Devi Patil, Pretesh R Kiran, K C Lakshmaiah, D Lokanatha
Multiple myeloma (MM) is a plasma cell neoplasm and constitutes 10% of hematologic malignancies. Malignant myelomatous pleural effusions are very rare and occur in <1% of cases of MM. In this article, we report a rare case of a patient who initially presented with pleural effusion and was subsequently found to be secondary to MM with an underlying raised IgG paraprotein. The patient symptomatically improved and was in partial remission with palliative radiotherapy, VTD chemotherapy, and bisphosphonates.
March 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28351708/biochemical-and-inhibition-studies-of-glutamine-synthetase-from-leishmania-donovani
#14
Vinay Kumar, Shailendra Yadav, Neelagiri Soumya, Rohit Kumar, Neerupudi Kishore Babu, Sushma Singh
Leishmaniasis is a group of tropical diseases caused by protozoan parasites of the genus Leishmania. Leishmania donovani is a protozoan parasite that causes visceral leishmaniasis, a fatal disease if left untreated. Chemotherapy for leishmaniasis is problematic as the available drugs are toxic, costly and shows drug resistance, hence, there is a necessity to look out for the novel drug targets, chemical entities and vaccine. Glutamine synthetase (GS) catalyzes the synthesis of glutamine from glutamate and ammonia...
June 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28299407/design-and-development-of-acetylthiocholine-electrochemical-biosensor-based-on-zinc-oxide-cerium-oxide-nanohybrid-modified-platinum-electrode
#15
Manju Bhargavi Gumpu, Noel Nesakumar, Srinidhi Nagarajan, Sadhana Ramanujam, Uma Maheswari Krishnan, K Jayanth Babu, John Bosco Balaguru Rayappan
Acetylcholinesterase (AChE) enzyme has been predominantly used for the detection of pesticides and metal ions. But, these sensors respond to pesticides as well as metal ions at certain concentration, which results in poor selectivity. Hence in this work, the amount of thiocholine produced during AChE inhibition has been estimated to detect the residual activity of AChE enzyme in-turn to enhance the efficiency of the biosensor. In this context, Pt/ZnO-CeO2/AChE/Chitosan based biosensor has been developed for sensitive voltammetric quantification of thiocholine in AChE...
May 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28270427/contemporary-cardiac-surgery-for-adults-with-congenital-heart-disease
#16
Sylvain Beurtheret, Oktay Tutarel, Gerhard Paul Diller, Cathy West, Evangelia Ntalarizou, Noémie Resseguier, Vasileios Papaioannou, Richard Jabbour, Victoria Simpkin, Anthony J Bastin, Sonya V Babu-Narayan, Beatrice Bonello, Wei Li, Babulal Sethia, Hideki Uemura, Michael A Gatzoulis, Darryl Shore
OBJECTIVE: Advances in early management of congenital heart disease (CHD) have led to an exponential growth in adults with CHD (ACHD). Many of these patients require cardiac surgery. This study sought to examine outcome and its predictors for ACHD cardiac surgery. METHODS: This is an observational cohort study of prospectively collected data on 1090 consecutive adult patients with CHD, undergoing 1130 cardiac operations for CHD at the Royal Brompton Hospital between 2002 and 2011...
August 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28228725/differential-effects-of-corm-2-and-corm-401-in-murine-intestinal-epithelial-mode-k-cells-under-oxidative-stress
#17
Dinesh Babu, Georges Leclercq, Roberto Motterlini, Romain A Lefebvre
Carbon monoxide (CO)-releasing molecules (CO-RMs) are intensively studied to provide cytoprotective and anti-inflammatory effects of CO in inflammatory conditions including intestinal inflammation. The water-soluble CORM-A1 reduced apoptosis and NADPH oxidase (NOX)-derived reactive oxygen species (ROS) induced by tumor necrosis factor (TNF)-α/cycloheximide (CHX) in mouse MODE-K intestinal epithelial cells (IECs), without influencing TNF-α/CHX-induced mitochondrial superoxide anion ([Formula: see text]). The aim of the present study in the same model was to comparatively investigate the influence of lipid-soluble CORM-2 and water-soluble CORM-401, shown in vitro to release more CO under oxidative conditions...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28218604/everolimus-eluting-bioresorbable-vascular-scaffolds-for-treatment-of-complex-chronic-total-occlusions
#18
Jiang Ming Fam, Soledad Ojeda, Roberto Garbo, Azeem Latib, Alessio La Manna, Beatriz Vaquerizo, Marouane Boukhris, Georgios J Vlachojannis, Robert-Jan van Geuns, Babu Ezhumalai, Hiroyoshi Kawamoto, Jors van der Sijde, Cordula Felix, Manuel Pan, Roberta Serdoz, Giacomo Giovanni Boccuzzi, Marcella De Paolis, Gennaro Sardella, Massimo Mancone, Corrado Tamburino, Pieter C Smits, Carlo Di Mario, Ashok Seth, Antonio Serra, Antonio Colombo, Patrick Serruys, Alfredo R Galassi, Felix Zijlstra, Nicolas M Van Mieghem, Roberto Diletti
AIMS: Bioresorbable vascular scaffolds (BVS) represent a novel therapeutic option for the treatment of coronary artery diseases. The objective of this study was to evaluate the feasibility of BVS implantation in complex chronic total occlusions (CTO). METHODS AND RESULTS: The present report is a multicentre registry evaluating results after BVS deployment in challenging CTO lesions, defined as J-CTO score ≥2 (difficult or very difficult). A total of 105 patients were included in the present analysis...
June 20, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28105955/small-rna-profiles-in-soybean-primary-root-tips-under-water-deficit
#19
Yun Zheng, Vandana Hivrale, Xiaotuo Zhang, Babu Valliyodan, Christine Lelandais-Brière, Andrew D Farmer, Gregory D May, Martin Crespi, Henry T Nguyen, Ramanjulu Sunkar
BACKGROUND: Soybean (Glycine max) production is significantly hampered by frequent droughts in many regions of the world including the United States. Identifying microRNA (miRNA)-controlled posttranscriptional gene regulation under drought will enhance our understanding of molecular basis of drought tolerance in this important cash crop. Indeed, miRNA profiles in soybean exposed to drought were studied but not from the primary root tips, which is not only a main zone of water uptake but also critical for water stress sensing and signaling...
December 5, 2016: BMC Systems Biology
https://www.readbyqxmd.com/read/28088018/antibacterial-serine-protease-from-wrightia-tinctoria-purification-and-characterization
#20
Sakthivel Muthu, Venkatesh Babu Gopal, Selvakumar Soundararajan, Karthikeyan Nattarayan, Karthik S Narayan, Mythileeswari Lakshmikanthan, Sathuvan Malairaj, Palani Perumal
A serine protease was purified from the leaves of Wrightia tinctoria by sequential flow through method comprising screening, optimization, ammonium sulfate precipitation, gel filtration and ion exchange column chromatography. The yield and purification fold obtained were 11.58% and 9.56 respectively. A single band of serine protease was visualized on SDS-PAGE and 2-D gel electrophoretic analyses were revealed with the molecular mass of 38.5 kDa. Serine protease had an optimum pH of 8.0 and was stable at 45°C with high relative protease activity...
March 2017: Plant Physiology and Biochemistry: PPB
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