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Carl H June

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https://www.readbyqxmd.com/read/27887864/optimization-of-cgmp-purification-and-expansion-of-umbilical-cord-blood-derived-t-regulatory-cells-in-support-of-first-in-human-clinical-trials
#1
David H McKenna, Darin Sumstad, Diane M Kadidlo, Bjorn Batdorf, Colin J Lord, Sarah C Merkel, Christine M Koellner, Julie M Curtsinger, Carl H June, James L Riley, Bruce L Levine, Jeffrey S Miller, Claudio G Brunstein, John E Wagner, Bruce R Blazar, Keli L Hippen
BACKGROUND AIMS: Thymic-derived regulatory T cells (tTreg) are critical regulators of the immune system. Adoptive tTreg transfer is a curative therapy for murine models of autoimmunity, graft rejection, and graft-versus-host disease (GVHD). We previously completed a "first-in-human" clinical trial using in vitro expanded umbilical cord blood (UCB)-derived tTreg to prevent GVHD in patients undergoing UCB hematopoietic stem cell transplantation (HSCT). tTreg were safe and demonstrated clinical efficacy, but low yield prevented further dose escalation...
November 22, 2016: Cytotherapy
https://www.readbyqxmd.com/read/27855210/potent-and-broad-inhibition-of-hiv-1-by-a-peptide-from-the-gp41-heptad-repeat-2-domain-conjugated-to-the-cxcr4-amino-terminus
#2
George J Leslie, Jianbin Wang, Max W Richardson, Beth S Haggarty, Kevin L Hua, Jennifer Duong, Anthony J Secreto, Andrea P O Jordon, Josephine Romano, Kritika E Kumar, Joshua J DeClercq, Philip D Gregory, Carl H June, Michael J Root, James L Riley, Michael C Holmes, James A Hoxie
HIV-1 entry can be inhibited by soluble peptides from the gp41 heptad repeat-2 (HR2) domain that interfere with formation of the 6-helix bundle during fusion. Inhibition has also been seen when these peptides are conjugated to anchoring molecules and over-expressed on the cell surface. We hypothesized that potent anti-HIV activity could be achieved if a 34 amino acid peptide from HR2 (C34) were brought to the site of virus-cell interactions by conjugation to the amino termini of HIV-1 coreceptors CCR5 or CXCR4...
November 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27852399/-analysis-of-the-influence-factors-of-school-age-children-s-refractive-status
#3
Z G Chen, M C Chen, J Y Zhang, D Q Cai, Q Wang, S S Lin, J W Chen, H L Zhong
Objective: To analyze the influence of the eye biological parameters, height, and weight on the school-age children's refractive status. Methods: Cross-sectional study. A total of 1 656 children (1 656 eyes), aged from 7 to 14 years, were selected from 8 schools in Wenzhou during June 2012 and June 2013. The height and weight of each child were measured, and the body mass index (BMI) was calculated. The eye biological parameters, including axial length (AL), corneal power (C=1/CR), anterior chamber depth (ACD), and white to white (WTW), were measured by IOLMaster (version 5...
November 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27815355/multiplex-genome-editing-to-generate-universal-car-t-cells-resistant-to-pd1-inhibition
#4
Jiangtao Ren, Xiaojun Liu, Chongyun Fang, Shuguang Jiang, Carl H June, Yangbing Zhao
PURPOSE: Using gene-disrupted allogeneic T cells as universal effector cells provides an alternative to and potentially improves current chimeric antigen receptor (CAR) T cell therapy against cancers and infectious diseases. EXPERIMENTAL DESIGN: The CRISPR/Cas9 system has recently emerged as a simple and efficient way for multiplex genome engineering. By combining the lentiviral delivery of CAR and CRISPR RNA electroporation to co-introduce RNA encoding the Cas9 and gRNAs targeting endogenous TCR, beta-2 microglobulin (B2M) and PD1 simultaneously, to generate gene-disrupted allogeneic CAR T cells deficient of TCR, HLA class I molecule and PD1...
November 4, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27745631/evaluating-the-skin-in-patients-undergoing-chimeric-antigen-receptor-modified-t-cell-therapy
#5
Courtney B Rubin, Rosalie Elenitsas, Laura Taylor, Simon F Lacey, Irina Kulikovskaya, Minnal Gupta, Jan J Melenhorst, Alison Loren, Noelle Frey, Carl H June, David Porter, Misha Rosenbach
No abstract text is available yet for this article.
November 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27668293/a-cure-for-hiv-infection-not-in-my-lifetime-or-just-around-the-corner
#6
Michael M Lederman, Paula M Cannon, Judith S Currier, Carl H June, Hans Peter Kiem, Daniel R Kuritzkes, Sharon R Lewin, David M Margolis, Joseph M McCune, John W Mellors, Timothy W Schacker, Rafick P Sekaly, Pablo Tebas, Bruce D Walker, Daniel C Douek
With the advent and stunning success of combination antiretroviral therapy (ART) to prolong and improve quality of life for persons with HIV infection, HIV research has been afforded the opportunity to pivot towards studies aimed at finding "a cure." The mere idea that cure of HIV might be possible has energized researchers and the community towards achieving this goal. Funding agencies, both governmental and private, have targeted HIV cure as a high priority; many in the field have responded to these initiatives and the cure research agenda is robust...
2016: Pathogens & Immunity
https://www.readbyqxmd.com/read/27632680/cytokine-release-syndrome-after-chimeric-antigen-receptor-t-cell-therapy-for-acute-lymphoblastic-leukemia
#7
Julie C Fitzgerald, Scott L Weiss, Shannon L Maude, David M Barrett, Simon F Lacey, J Joseph Melenhorst, Pamela Shaw, Robert A Berg, Carl H June, David L Porter, Noelle V Frey, Stephan A Grupp, David T Teachey
OBJECTIVE: Initial success with chimeric antigen receptor-modified T cell therapy for relapsed/refractory acute lymphoblastic leukemia is leading to expanded use through multicenter trials. Cytokine release syndrome, the most severe toxicity, presents a novel critical illness syndrome with limited data regarding diagnosis, prognosis, and therapy. We sought to characterize the timing, severity, and intensive care management of cytokine release syndrome after chimeric antigen receptor-modified T cell therapy...
September 14, 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27584485/peripheral-qct-sector-analysis-reveals-positive-bone-adaptations-following-osteogenic-index-optimized-exercise-2874-board-6-june-3-1-00-pm-3-00-pm
#8
Joseph R Pierce, Kathleen N Beasley, Amanda J Centi, Dennis E Scofield, Charles H Negus, Rachel K Evans, Carl M Maresh, William J Kraemer, Bradley C Nindl
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27571406/dual-cd19-and-cd123-targeting-prevents-antigen-loss-relapses-after-cd19-directed-immunotherapies
#9
Marco Ruella, David M Barrett, Saad S Kenderian, Olga Shestova, Ted J Hofmann, Jessica Perazzelli, Michael Klichinsky, Vania Aikawa, Farzana Nazimuddin, Miroslaw Kozlowski, John Scholler, Simon F Lacey, Jan J Melenhorst, Jennifer J D Morrissette, David A Christian, Christopher A Hunter, Michael Kalos, David L Porter, Carl H June, Stephan A Grupp, Saar Gill
Potent CD19-directed immunotherapies, such as chimeric antigen receptor T cells (CART) and blinatumomab, have drastically changed the outcome of patients with relapsed/refractory B cell acute lymphoblastic leukemia (B-ALL). However, CD19-negative relapses have emerged as a major problem that is observed in approximately 30% of treated patients. Developing approaches to preventing and treating antigen-loss escapes would therefore represent a vertical advance in the field. Here, we found that in primary patient samples, the IL-3 receptor α chain CD123 was highly expressed on leukemia-initiating cells and CD19-negative blasts in bulk B-ALL at baseline and at relapse after CART19 administration...
October 3, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27550819/engineered-t-cells-the-promise-and-challenges-of-cancer-immunotherapy
#10
Andrew D Fesnak, Carl H June, Bruce L Levine
The immune system evolved to distinguish non-self from self to protect the organism. As cancer is derived from our own cells, immune responses to dysregulated cell growth present a unique challenge. This is compounded by mechanisms of immune evasion and immunosuppression that develop in the tumour microenvironment. The modern genetic toolbox enables the adoptive transfer of engineered T cells to create enhanced anticancer immune functions where natural cancer-specific immune responses have failed. Genetically engineered T cells, so-called 'living drugs', represent a new paradigm in anticancer therapy...
August 23, 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27531112/-analysis-of-myopia-and-axial-length-changes-and-relevant-factors-of-children-aged-7-to-14-years-in-wenzhou
#11
J Y Zhang, Q Wang, S S Lin, J W Chen, H L Zhong, D Q Ca, Z G Chen
OBJECTIVE: To investigate the incidence and features of myopia in children aged 7 to 14 years. METHODS: Cross-sectional study. A total of 2 226 children (2 226 eyes) aged 7 to 14 years were selected from school during June 2012 and January 2015. Refraction was measured by fast cycloplegic retinoscopy. SPSS16.0 was used to analyze the data. Ocular refractive parameters, including axial length (AL), corneal power, anterior chamber depth, and white to white, were measured by IOLMaster (version 5...
July 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27506378/rethinking-the-regulatory-infrastructure-for-human-gene-transfer-clinical-trials
#12
Christopher L Jenkins, Mark L Bagarazzi, Hans-Peter Kiem, Arnold J Levine, Dale Ando, Carl H June, Tony Reid, David W Emery
No abstract text is available yet for this article.
August 2016: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/27485827/mir-146b-antagomir-treated-human-tregs-acquire-increased-gvhd-inhibitory-potency
#13
Yunjie Lu, Keli L Hippen, Amanda L Lemire, Jian Gu, Weizhi Wang, Xuhao Ni, Parvathi Ranganathan, Bruce L Levine, James L Riley, Carl H June, Laurence A Turka, David H Munn, Ramiro Garzon, Ling Lu, Bruce R Blazar
CD4(+)CD25(+)FoxP3(+) thymic-derived regulatory T cells (tTregs) are indispensable for maintaining immune system equilibrium. Adoptive transfer of tTregs is an effective means of suppressing graft-versus-host disease (GVHD) in murine models and in early human clinical trials. Tumor necrosis factor receptor-associated factor 6 (TRAF6), an ubiquitin-conjugating enzyme that mediates nuclear factor κB (NF-κB) activation, plays an essential role in modulating regulatory T cell survival and function. MicroRNAs (miRNAs) are noncoding RNAs, which mediate RNA silencing and posttranscriptional gene repression...
September 8, 2016: Blood
https://www.readbyqxmd.com/read/27475429/chimeric-antigen-receptor-t-cells-for-b-cell-neoplasms-choose-the-right-car-for-you
#14
REVIEW
Marco Ruella, Carl H June
Genetic redirection of T lymphocytes allows us to unleash these potent cellular immune effectors against cancer. Chimeric antigen receptor (CAR) T cells are the best-in-class example that genetic engineering of T cells can lead to deep and durable responses, as has been shown in several clinical trials for CD19+ B cell malignancies. As a consequence, in the last few years, several academic institutions and commercial partners have started developing anti-CD19 CAR T cell products. Although most of these T cell products are highly effective in vivo, basic differences among them can generate different performance characteristics and thereby impact their long-term clinical outcome...
October 2016: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/27467909/ovarian-cancer-chemokines-may-not-be-a-significant-barrier-during-whole-tumor-antigen-dendritic-cell-vaccine-and-adoptive-t-cell-immunotherapy
#15
Emese Zsiros, Denarda Dangaj, Carl H June, Lana E Kandalaft, George Coukos
Tumor barriers preventing T-cell homing and engraftment should be neutralized during cancer immunotherapy. We recently discovered that ovarian cancer expresses quasi-universal chemokines that can support T-cell homing. Furthermore, T cells elicited by whole tumor antigen dendritic-cell vaccines express cognate chemokine receptors which are upregulated by CD3/CD28 costimulation.
May 2016: Oncoimmunology
https://www.readbyqxmd.com/read/27381203/impact-of-an-electronic-medical-record-screening-tool-and-therapist-driven-protocol-on-length-of-stay-and-hospital-readmission-for-copd
#16
EDITORIAL
Karen D LaRoché, Carl R Hinkson, Brett A Thomazin, Paula K Minton-Foltz, David J Carlbom
BACKGROUND: In the United States, care for COPD patients is frequently delivered by respiratory therapists (RTs). After implementing a therapist-driven protocol for COPD treatment, we sought to improve identification of COPD patients. We hypothesized that using an electronic medical record screening tool to identify subjects with COPD combined with a therapist-driven protocol would positively impact length of stay (LOS) and readmission rates. METHODS: Utilizing the electronic medical record to search the provider's admission notes for the terms COPD/Asthma, a report was generated...
September 2016: Respiratory Care
https://www.readbyqxmd.com/read/27362049/pathogenesis-and-symptomology-of-the-exercise-hypogonodal-male-condition-3683-board-122-june-4-9-30-am-11-00-am
#17
David R Hooper, Kevin E Schill, Catherine Saenz, Emily R Martini, Shawn D Flanagan, Tunde K Szivak, William H DuPont, Brian C Focht, Jeff S Volek, Carl M Maresh, William J Kraemer
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27360245/eversion-ankle-injury-football-1326-june-2-8-00-am-8-20-am
#18
Carl H Russell, James B Robinson
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27359759/the-influence-of-different-training-programs-on-the-expression-of-plasma-proenkephalin-peptide-f-in-women-504-board-341-june-1-11-00-am-12-30-pm
#19
William H DuPont, William J Kraemer, Bradley C Nindl, Jakob L Vingren, Barry A Spiering, Shawn D Flanagan, Lydia K Caldwell, Tunde K Szivak, Emily C Barnhart, Emily C Borden, Carl M Maresh
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27359450/medial-tibial-stress-syndrome-reliably-diagnosed-using-history-and-clinical-examination-195-board-32-june-1-11-00-am-12-30-pm
#20
Marinus Winters, Carl C Barten, Rens Teeuwen, Eric W P Bakker, Maarten H Moen, Frank J G Backx, Adam Weir
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
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