keyword
MENU ▼
Read by QxMD icon Read
search

Thalamus and epilepsy

keyword
https://www.readbyqxmd.com/read/28061418/memory-and-mood-outcomes-after-anterior-thalamic-stimulation-for-refractory-partial-epilepsy
#1
Alexander I Tröster, Kimford J Meador, Christopher P Irwin, Robert S Fisher
PURPOSE: Bilateral deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) reduces seizures and is relatively safe but may be accompanied by complaints of memory problems and depression. This study examined incidence of memory and depression adverse events (AE) in the SANTE study blinded phase and their relationship to objective neurobehavioral measures, baseline characteristics, quality of life and long-term neurobehavioral outcome. METHOD: The neurobehavioral AE and neuropsychological data from a previously reported prospective randomized trial (SANTE) were analyzed...
December 23, 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28048162/su-f-r-08-can-normalization-of-brain-mri-texture-features-reduce-scanner-dependent-effects-in-unsupervised-machine-learning
#2
K Ogden, T Bradford, L Cussen, R O'Dwyer
PURPOSE: To reduce differences in features calculated from MRI brain scans acquired at different field strengths with or without Gadolinium contrast. METHODS: Brain scans were processed for 111 epilepsy patients to extract hippocampus and thalamus features. Scans were acquired on 1.5 T scanners with Gadolinium contrast (group A), 1.5T scanners without Gd (group B), and 3.0 T scanners without Gd (group C). A total of 72 features were extracted. Features were extracted from original scans and from scans where the image pixel values were rescaled to the mean of the hippocampi and thalami values...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043066/thalamic-hypoperfusion-and-disrupted-cerebral-blood-flow-networks-in-idiopathic-generalized-epilepsy-arterial-spin-labeling-and-graph-theoretical-analysis
#3
Daichi Sone, Masako Watanabe, Miho Ota, Yukio Kimura, Atsuhiko Sugiyama, Tomoko Maekawa, Mariko Okura, Mikako Enokizono, Etsuko Imabayashi, Noriko Sato, Hiroshi Matsuda
PURPOSE: The aim of this study was to investigate interictal cerebral blood flow (CBF) distributions and graph theoretical networks in idiopathic generalized epilepsy (IGE) using arterial spin labeling (ASL) imaging and anatomical covariance methods of graph theoretical analysis. MATERIAL AND METHODS: We recruited 19 patients with IGE and 19 age-/gender-matched healthy controls. Their CBF images were obtained by pseudo-continuous ASL imaging and compared using statistical parametric mapping 8 software (SPM8) and Graph Analysis Toolbox (GAT)...
December 14, 2016: Epilepsy Research
https://www.readbyqxmd.com/read/28041911/disinhibition-of-the-intergeniculate-leaflet-network-in-the-wag-rij-rat-model-of-absence-epilepsy
#4
Lukasz Chrobok, Katarzyna Palus, Jagoda Stanislawa Jeczmien-Lazur, Anna Chrzanowska, Mariusz Kepczynski, Marian Henryk Lewandowski
The intergeniculate leaflet (IGL) of the thalamus is a retinorecipient structure implicated in orchestrating circadian rhythmicity. The IGL network is highly GABAergic and consists mainly of neuropeptide Y-synthesising and enkephalinergic neurons. A high density of GFAP-immunoreactive astrocytes has been observed in the IGL, with a probable function in guarding neuronal inhibition. Interestingly, putatively enkephalinergic IGL neurons generate action potentials with an infra-slow oscillatory (ISO) pattern in vivo in urethane anesthetised Wistar rats, under light-on conditions only...
December 30, 2016: Experimental Neurology
https://www.readbyqxmd.com/read/28030998/the-role-of-thalamus-versus-cortex-in-epilepsy-evidence-from-human-ictal-centromedian-recordings-in-patients-assessed-for-deep-brain-stimulation
#5
David Martín-López, Diego Jiménez-Jiménez, Lidia Cabañés-Martínez, Richard P Selway, Antonio Valentín, Gonzalo Alarcón
BACKGROUND: The onset of generalized seizures is a long debated subject in epilepsy. The relative roles of cortex and thalamus in initiating and maintaining the different seizure types are unclear. OBJECTIVE: The purpose of the study is to estimate whether the cortex or the centromedian thalamic nucleus is leading in initiating and maintaining seizures in humans. METHODS: We report human ictal recordings with simultaneous thalamic and cortical electrodes from three patients without anesthesia being assessed for deep brain stimulation (DBS)...
October 24, 2016: International Journal of Neural Systems
https://www.readbyqxmd.com/read/27965181/stimulation-of-the-bilateral-anterior-nuclei-of-the-thalamus-in-the-treatment-of-refractory-epilepsy-two-cases-of-subcortical-band-heterotopia
#6
Ana Franco, José Pimentel, Alexandre Rainha Campos, Carlos Morgado, Sara Pinelo, António Gonçalves Ferreira, Carla Bentes
Subcortical band heterotopia is a neuronal migration disorder that may cause refractory epilepsy. In these patients, resective surgery has yielded inadequate results. Deep brain stimulation of the anterior nuclei of the thalamus has been used for the treatment of refractory epilepsy with good results. We describe the first two patients with subcortical band heterotopia who were submitted to deep brain stimulation of the anterior nuclei of the thalamus, with evaluation of seizure outcome after 12 and 18 months of follow-up...
December 1, 2016: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/27942449/resting-state-functional-network-disruptions-in-a-kainic-acid-model-of-temporal-lobe-epilepsy
#7
Ravnoor Singh Gill, Seyed M Mirsattari, L Stan Leung
We studied the graph topological properties of brain networks derived from resting-state functional magnetic resonance imaging in a kainic acid induced model of temporal lobe epilepsy (TLE) in rats. Functional connectivity was determined by temporal correlation of the resting-state Blood Oxygen Level Dependent (BOLD) signals between two brain regions during 1.5% and 2% isoflurane, and analyzed as networks in epileptic and control rats. Graph theoretical analysis revealed a significant increase in functional connectivity between brain areas in epileptic than control rats, and the connected brain areas could be categorized as a limbic network and a default mode network (DMN)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27942447/altered-structural-and-functional-thalamocortical-networks-in-secondarily-generalized-extratemporal-lobe-seizures
#8
Syu-Jyun Peng, Yue-Loong Hsin
Structural and functional abnormalities in the thalamocortical network in primary generalized epilepsies or mesial temporal lobe epilepsy have recently been identified by voxel-wise analyses of neuroimaging. However, evidence is needed regarding the profiles of the thalamocortical network in patients with secondarily generalized seizures from focal neocortical sources. We used high-resolution T1-weighted, diffusion-tensor and resting-state functional MR imaging (rs-fMRI) to examine 16 patients with secondarily generalized extratemporal lobe seizures and 16 healthy controls...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27939427/a-developmental-study-of-glutamatergic-neuron-populations-in-the-ventrobasal-and-the-lateral-geniculate-nucleus-of-the-thalamus-comparing-genetic-absence-rats-from-strasbourg-gaers-and-normal-control-wistar-rats
#9
Özlem Kirazlı, Safiye Çavdar, Sercan Yıldızel, Filiz Onat, Erkan Kaptanoğlu
An imbalance of GABAergic inhibition and glutamatergic excitation is suspected to be the cause of absence epileptic seizures. Absence seizures are known to be generated in thalamocortical circuitry. In the present study we used light microscopy immunohistochemistry to quantify the density of glutamate+ve neurons at two developmental stages (P10 and P60) in two thalamic nuclei, the ventrobasal (VB) and lateral geniculate nucleus (LGN) in Wistar rats and compared the results with similar data obtained from genetic absence epilepsy rats from Strasbourg (GAERS)...
December 6, 2016: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/27923174/generalized-epilepsy-syndromes-and-callosal-thickness-differential-effects-between-patients-with-juvenile-myoclonic-epilepsy-and-those-with-generalized-tonic-clonic-seizures-alone
#10
Stavroula Anastasopoulou, Florian Kurth, Eileen Luders, Ivanka Savic
PURPOSE: The definition of two well-studied genetic generalized epilepsy syndromes (GGE) - juvenile myoclonic epilepsy (JME) and epilepsy with generalized tonic-clonic seizures alone (GTCS) - suggests the absence of structural cerebral abnormalities. Nevertheless, there are various reports of such abnormalities (especially in JME), where effects mainly occur within thalamus and mesial prefrontal regions. This raises the question of whether JME is particularly linked to midline structure abnormalities, which may also involve the corpus callosum...
November 18, 2016: Epilepsy Research
https://www.readbyqxmd.com/read/27897304/-the-role-of-diffusion-tensor-imaging-in-the-pre-surgical-study-of-temporal-lobe-epilepsy
#11
M A Garcia-Pallero, C V Torres, R Manzanares-Soler, E Camara, R G Sola
INTRODUCTION: Diffusion tensor imaging (DTI) is a non-invasive technique that can be used to assess the integrity of the white matter in the brain. AIMS: To investigate the usefulness of DTI in patients with temporal lobe epilepsy (TLE) and to observe its relationship with lateralisation of the epileptogenic focus in these patients. PATIENTS AND METHODS: We analysed 11 patients diagnosed with TLE in accordance with the pre-surgical protocol of our epilepsy unit, and who were seizure-free two years after performing a temporal lobectomy plus amygdalohippocampectomy (Spencer technique)...
December 16, 2016: Revista de Neurologia
https://www.readbyqxmd.com/read/27871881/targeting-brain-and-peripheral-plasticity-of-the-lipidome-in-acute-kainic-acid-induced-epileptic-seizures-in-mice-via-quantitative-mass-spectrometry
#12
Raissa Lerner, Julia Post, Sebastian Loch, Beat Lutz, Laura Bindila
Epilepsy is a highly common chronic neurological disorder, manifested in many different types, affecting ~1% of the worldwide human population. The molecular mechanisms of epileptogenesis have not yet been clarified, and pharmacoresistance exhibited by 30-40% of epilepsy patients remains a major obstacle in medical care. Growing evidence indicates a role of lipid signalling pathways in epileptogenesis, thus lipid signals emerge as potential biomarkers for the onset and evolving course of the epileptic disorder, as well as potential therapeutic agents and targets...
February 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27846633/variations-in-thalamic-anatomy-affect-targeting-in-deep-brain-stimulation-for-epilepsy
#13
Chengyuan Wu, Pierre-François D'Haese, Srivatsan Pallavaram, Benoit M Dawant, Peter Konrad, Ashwini D Sharan
BACKGROUND: Thalamic size and shape vary significantly across patients - with changes specific to the anterior thalamus occurring with age and in the setting of chronic epilepsy. Such ambiguity raises concerns regarding electrode position and potential implications for seizure outcomes. METHODS: MRIs from 6 patients from a single center underwent quantitative analysis. In addition to direct measurements from postimplantation MRIs, the CRAnialVault Explorer suite was used to normalize electrode position to a common reference system...
November 16, 2016: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/27829869/interaction-between-thalamus-and-hippocampus-in-termination-of-amygdala-kindled-seizures-in-mice
#14
Zhen Zhang, Jia-Jia Li, Qin-Chi Lu, Hai-Qing Gong, Pei-Ji Liang, Pu-Ming Zhang
The thalamus and hippocampus have been found both involved in the initiation, propagation, and termination of temporal lobe epilepsy. However, the interaction of these regions during seizures is not clear. The present study is to explore whether some regular patterns exist in their interaction during the termination of seizures. Multichannel in vivo recording techniques were used to record the neural activities from the cornu ammonis 1 (CA1) of hippocampus and mediodorsal thalamus (MDT) in mice. The mice were kindled by electrically stimulating basolateral amygdala neurons, and Racine's rank standard was employed to classify the stage of behavioral responses (stage 1~5)...
2016: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/27818364/might-the-olfactory-bulb-be-an-origin-of-olfactory-auras-in-focal-epilepsy
#15
Harvey B Sarnat, Laura Flores-Sarnat
Olfactory auras (phantosmia) are an infrequent phenomenon in complex focal seizures generated in the mesial temporal lobe. It is generally assumed that all such auras arise from epileptic foci in the entorhinal cortex, amygdala or rostral insula, all of which have major afferent projections from the olfactory bulb or mainly from its relay, the anterior olfactory nucleus. The histological morphology, synaptic circuitry, and foetal development of the olfactory bulb are unique. The olfactory system is the only special sensory system that does not project to the thalamus because its bulb and tract incorporate an intrinsic thalamic equivalent: axonless granular and periglomerular neurons and the anterior olfactory nucleus...
December 1, 2016: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/27797809/timing-and-significance-of-pathological-features-in-c9orf72-expansion-associated-frontotemporal-dementia
#16
Sarat C Vatsavayai, Soo Jin Yoon, Raquel C Gardner, Tania F Gendron, Jose Norberto S Vargas, Andrew Trujillo, Mochtar Pribadi, Joanna J Phillips, Stephanie E Gaus, John D Hixson, Paul A Garcia, Gil D Rabinovici, Giovanni Coppola, Daniel H Geschwind, Leonard Petrucelli, Bruce L Miller, William W Seeley
SEE SCABER AND TALBOT DOI101093/AWW264 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: A GGGGCC repeat expansion in C9orf72 leads to frontotemporal dementia and/or amyotrophic lateral sclerosis. Diverse pathological features have been identified, and their disease relevance remains much debated. Here, we describe two illuminating patients with frontotemporal dementia due to the C9orf72 repeat expansion. Case 1 was a 65-year-old female with behavioural variant frontotemporal dementia accompanied by focal degeneration in subgenual anterior cingulate cortex, amygdala, and medial pulvinar thalamus...
December 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/27792884/altered-basal-ganglia-cortical-functional-connections-in-frontal-lobe-epilepsy-a-resting-state-fmri-study
#17
Li Dong, Pu Wang, Rui Peng, Sisi Jiang, Benjamin Klugah-Brown, Cheng Luo, Dezhong Yao
OBJECTIVES: The purpose of this study was to investigate alterations of basal ganglia-cortical functional connections in patients with frontal lobe epilepsy (FLE). METHOD: Resting-state functional magnetic resonance imaging (fMRI) data were gathered from 19 FLE patients and 19 age- and gender-matched healthy controls. Functional connectivity (FC) analysis was used to assess the functional connections between basal ganglia and cerebral cortex. Regions of interest, including the left/right caudate, putamen, pallidum and thalamus, were selected as the seeds...
December 2016: Epilepsy Research
https://www.readbyqxmd.com/read/27769717/progressive-neuronal-activation-accompanies-epileptogenesis-caused-by-hippocampal-glutamine-synthetase-inhibition
#18
Benjamin Albright, Roni Dhaher, Helen Wang, Roa Harb, Tih-Shih W Lee, Hitten Zaveri, Tore Eid
Loss of glutamine synthetase (GS) in hippocampal astrocytes has been implicated in the causation of human mesial temporal lobe epilepsy (MTLE). However, the mechanism by which the deficiency in GS leads to epilepsy is incompletely understood. Here we ask how hippocampal GS inhibition affects seizure phenotype and neuronal activation during epilepsy development (epileptogenesis). Epileptogenesis was induced by infusing the irreversible GS blocker methionine sulfoximine (MSO) unilaterally into the hippocampal formation of rats...
February 2017: Experimental Neurology
https://www.readbyqxmd.com/read/27765558/juvenile-myoclonic-epilepsy-may-be-a-disorder-of-cortex-rather-than-thalamus-an-effective-connectivity-analysis
#19
Kang Min Park, Byung In Lee, Kyong Jin Shin, Sam Yeol Ha, JinSe Park, Si Eun Kim, Hyung Chan Kim, Tae Hyung Kim, Chi Woong Mun, Sung Eun Kim
Although juvenile myoclonic epilepsy has been considered as a disorder of thalamo-cortical circuit, it is not determined the causality relationship between thalamus and cortex. The aim of this study was to evaluate whether juvenile myoclonic epilepsy is a disorder of thalamus or cortex. Twenty-nine patients with juvenile myoclonic epilepsy and 20 normal controls were enrolled in this study. In addition, we included 10 patients with childhood absence epilepsy as a disease control group. Using whole-brain T1-weighted MRIs, we analyzed the volumes of the structures, including hippocampus, thalamus, and total cortex, with FreeSurfer 5...
January 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27723660/relationship-between-postoperative-eeg-driving-response-and-lead-location-in-deep-brain-stimulation-of-the-anterior-nucleus-of-the-thalamus-for-refractory-epilepsy
#20
Byung-Chul Son, Young Min Shon, Seong-Hoon Kim, Jin-Gyu Choi, Jiyeon Kim
OBJECTIVES: Interpreting the postoperative electroencephalographic (EEG) driving response (DR) as an indicator of electrode placement within the thalamic nucleus in deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) for refractory epilepsy is controversial. MATERIALS AND METHODS: We retrospectively investigated the relationship between postoperative EEG DR and the location of 11 electrodes in 6 patients who underwent ANT DBS for refractory epilepsy...
2016: Stereotactic and Functional Neurosurgery
keyword
keyword
76737
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"