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https://www.readbyqxmd.com/read/28285213/remote-modulation-of-network-excitability-during-deep-brain-stimulation-for-epilepsy
#1
REVIEW
Dong-Hong Li, Xiao-Feng Yang
Deep brain stimulation (DBS) has become a well-accepted medical therapy in the treatment of movement disorders such as Parkinson's disease, and is currently under investigation as a treatment for other disorders, including epilepsy. Although DBS is widely used, its therapeutic mechanisms remain poorly understood. Recent research shows that seizures are network-level phenomena, but the incomplete knowledge of neural circuit function has left a gap in our understanding of how disruption at a molecular or cellular level generates epilepsy...
March 4, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28269577/sinusoidal-stimulation-trains-suppress-epileptiform-spikes-induced-by-4-ap-in-the-rat-hippocampal-ca1-region-in-vivo
#2
Zheshan Guo, Zhouyan Feng, Ying Yu, Wenjie Zhou, Zhaoxiang Wang, Xuefeng Wei
Deep brain stimulation (DBS) shows promises in the treatment of refractory epilepsy. Due to the complex causes of epilepsy, the mechanisms of DBS are still unclear. Depolarization block caused by the persistent excitation of neurons may be one of the possible mechanisms. To test the hypothesis, 4-aminopyridine (4-AP) was injected in rat hippocampal CA1 region in-vivo to induce epileptiform activity. Sinusoidal stimulation trains were applied to the afferent pathway (Schaffer collaterals) of CA1 region to suppress the epileptiform spikes...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269576/detection-of-single-unit-spikes-during-orthodromic-high-frequency-stimulation-in-rat-hippocampus
#3
Zhaoxiang Wang, Zhouyan Feng, Ying Yu, Yufang Zhu, Zheshan Guo
Deep brain stimulation (DBS) has been used as a treatment of brain diseases such as Parkinson's disease and is a promising therapy for epilepsy. But the mechanisms of high frequency stimulation (HFS) used by DBS are still uncertain. In order to investigate the changes of action penitential firings of individual neurons (single unit activity, SUA) during the period of HFS, a new algorithm based on window detection was designed to detect spikes in broadband-frequency recording signals. The results show that orthodromic-HFS (O-HFS) could excite the neurons in CA1 regions, and the firing rate of interneurons and pyramidal neurons increased significantly...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28251589/neurostimulation-devices-used-in-treatment-of-epilepsy
#4
REVIEW
Evren Burakgazi Dalkilic
Epilepsy is a chronic neurological disorder frequently requiring lifelong treatment. In 70% of epilepsy patients, seizures are well controlled by antiepileptic medications. About 30% of epilepsy patients remain refractory to medical treatments and may need surgical interventions for better seizure control. Unfortunately and not infrequently, surgical intervention is not feasible due to various reasons such as multiple seizure foci, not resectable focus because of eloquent cortex location, or inability to tolerate surgery due to ongoing concomitant medical conditions...
February 2017: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/28227832/sinusoidal-stimulation-trains-suppress-epileptiform-spikes-induced-by-4-ap-in-the-rat-hippocampal-ca1-region-in-vivo
#5
Zheshan Guo, Zhouyan Feng, Ying Yu, Wenjie Zhou, Zhaoxiang Wang, Xuefeng Wei, Zheshan Guo, Zhouyan Feng, Ying Yu, Wenjie Zhou, Zhaoxiang Wang, Xuefeng Wei, Ying Yu, Zhouyan Feng, Xuefeng Wei, Zhaoxiang Wang, Zheshan Guo, Wenjie Zhou
Deep brain stimulation (DBS) shows promises in the treatment of refractory epilepsy. Due to the complex causes of epilepsy, the mechanisms of DBS are still unclear. Depolarization block caused by the persistent excitation of neurons may be one of the possible mechanisms. To test the hypothesis, 4-aminopyridine (4-AP) was injected in rat hippocampal CA1 region in-vivo to induce epileptiform activity. Sinusoidal stimulation trains were applied to the afferent pathway (Schaffer collaterals) of CA1 region to suppress the epileptiform spikes...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227831/detection-of-single-unit-spikes-during-orthodromic-high-frequency-stimulation-in-rat-hippocampus
#6
Zhaoxiang Wang, Zhouyan Feng, Ying Yu, Yufang Zhu, Zheshan Guo, Zhaoxiang Wang, Zhouyan Feng, Ying Yu, Yufang Zhu, Zheshan Guo, Yufang Zhu, Ying Yu, Zhouyan Feng, Zhaoxiang Wang, Zheshan Guo
Deep brain stimulation (DBS) has been used as a treatment of brain diseases such as Parkinson's disease and is a promising therapy for epilepsy. But the mechanisms of high frequency stimulation (HFS) used by DBS are still uncertain. In order to investigate the changes of action penitential firings of individual neurons (single unit activity, SUA) during the period of HFS, a new algorithm based on window detection was designed to detect spikes in broadband-frequency recording signals. The results show that orthodromic-HFS (O-HFS) could excite the neurons in CA1 regions, and the firing rate of interneurons and pyramidal neurons increased significantly...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28061418/memory-and-mood-outcomes-after-anterior-thalamic-stimulation-for-refractory-partial-epilepsy
#7
Alexander I Tröster, Kimford J Meador, Christopher P Irwin, Robert S Fisher
PURPOSE: Bilateral deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) reduces seizures and is relatively safe but may be accompanied by complaints of memory problems and depression. This study examined incidence of memory and depression adverse events (AE) in the SANTE study blinded phase and their relationship to objective neurobehavioral measures, baseline characteristics, quality of life and long-term neurobehavioral outcome. METHOD: The neurobehavioral AE and neuropsychological data from a previously reported prospective randomized trial (SANTE) were analyzed...
February 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28030998/the-role-of-thalamus-versus-cortex-in-epilepsy-evidence-from-human-ictal-centromedian-recordings-in-patients-assessed-for-deep-brain-stimulation
#8
David Martín-López, Diego Jiménez-Jiménez, Lidia Cabañés-Martínez, Richard P Selway, Antonio Valentín, Gonzalo Alarcón
BACKGROUND: The onset of generalized seizures is a long debated subject in epilepsy. The relative roles of cortex and thalamus in initiating and maintaining the different seizure types are unclear. OBJECTIVE: The purpose of the study is to estimate whether the cortex or the centromedian thalamic nucleus is leading in initiating and maintaining seizures in humans. METHODS: We report human ictal recordings with simultaneous thalamic and cortical electrodes from three patients without anesthesia being assessed for deep brain stimulation (DBS)...
October 24, 2016: International Journal of Neural Systems
https://www.readbyqxmd.com/read/27992003/neuromodulation-in-refractory-epilepsy-brazilian-specialists-consensus
#9
Vera Cristina Terra, Isabella D'Andrea-Meira, Ricardo Amorim, Francisco Arruda, Andrea Julião de Oliveira, Luciano De Paola, Adélia Maria de Miranda Henriques-Souza
Epilepsy is a potentially devastating brain disorder characterized by a predisposition to spontaneous epileptic seizures. In patients with medically refractory epilepsy, new non-pharmacological therapeutic approaches may be considered. In this scenario, palliative surgery such as vagus nerve stimulation (VNS) or deep brain stimulation (DBS) may be indicated in a subset of patients. In this paper we make recommendations for the use of VNS and DBS in patients in Brazil with refractory epilepsy.
December 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/27723660/relationship-between-postoperative-eeg-driving-response-and-lead-location-in-deep-brain-stimulation-of-the-anterior-nucleus-of-the-thalamus-for-refractory-epilepsy
#10
Byung-Chul Son, Young Min Shon, Seong-Hoon Kim, Jin-Gyu Choi, Jiyeon Kim
OBJECTIVES: Interpreting the postoperative electroencephalographic (EEG) driving response (DR) as an indicator of electrode placement within the thalamic nucleus in deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) for refractory epilepsy is controversial. MATERIALS AND METHODS: We retrospectively investigated the relationship between postoperative EEG DR and the location of 11 electrodes in 6 patients who underwent ANT DBS for refractory epilepsy...
2016: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/27715438/prediction-and-detection-of-seizures-from-simultaneous-thalamic-and-scalp-electroencephalography-recordings
#11
Rosa Q So, Vibhor Krishna, Nicolas Kon Kam King, Huijuan Yang, Zhuo Zhang, Francesco Sammartino, Andres M Lozano, Richard A Wennberg, Cuntai Guan
OBJECTIVE The authors explored the feasibility of seizure detection and prediction using signals recorded from the anterior thalamic nucleus, a major target for deep brain stimulation (DBS) in the treatment of epilepsy. METHODS Using data from 5 patients (13 seizures in total), the authors performed a feasibility study and analyzed the performance of a seizure prediction and detection algorithm applied to simultaneously acquired scalp and thalamic electroencephalography (EEG). The thalamic signal was obtained from DBS electrodes...
October 7, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27645504/an-unexpectedly-high-rate-of-revisions-and-removals-in-deep-brain-stimulation-surgery-analysis-of-multiple-databases
#12
John D Rolston, Dario J Englot, Philip A Starr, Paul S Larson
INTRODUCTION: Deep brain stimulation (DBS) is an established therapy for movement disorders, and is under active investigation for other neurologic and psychiatric indications. While many studies describe outcomes and complications related to stimulation therapies, the majority of these are from large academic centers, and results may differ from those in general neurosurgical practice. METHODS: Using data from both the Centers for Medicare and Medicaid Services (CMS) and the National Surgical Quality Improvement Program (NSQIP), we identified all DBS procedures related to primary placement, revision, or removal of intracranial electrodes...
December 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27642815/effectiveness-and-adverse-effects-of-deep-brain-stimulation-umbrella-review-of-meta-analyses
#13
Panagiotis N Papageorgiou, James Deschner, Spyridon N Papageorgiou
Background This umbrella review summarizes the evidence across meta-analyses regarding the effectiveness and adverse effects of deep brain stimulation (DBS). Methods Databases were searched up to March 2015 for meta-analyses of comparative trials in humans assessing the effectiveness or adverse effects of DBS. Data selection, data extraction, and risk of bias assessment were performed by two independent reviewers. Results Seven eligible systematic reviews were included assessing the use of DBS for epilepsy (n = 1), obsessive-compulsive disorder (n = 1), and Parkinson disease (n = 5)...
March 2017: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/27636181/modification-of-electrophysiological-activity-pattern-after-anterior-thalamic-deep-brain-stimulation-for-intractable-epilepsy-report-of-3-cases
#14
Hae Yu Kim, Yun Jung Hur, Heung-Dong Kim, Kang Min Park, Sung Eun Kim, Tae Gyu Hwang
OBJECTIVE Thalamic stimulation can provoke electroencephalography (EEG) synchronization or desynchronization, which can help to reduce the occurrence of seizures in intractable epilepsy, though the underlying mechanism is not fully understood. Therefore, the authors investigated changes in EEG electrical activity to better understand the seizure-reducing effects of deep brain stimulation (DBS) in patients with intractable epilepsy. METHODS Electrical activation patterns in the epileptogenic brains of 3 patients were analyzed using classical low-resolution electromagnetic tomography analysis recursively applied (CLARA)...
September 16, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27620666/a-new-bio-inspired-stimulator-to-suppress-hyper-synchronized-neural-firing-in-a-cortical-network
#15
Masoud Amiri, Mahmood Amiri, Soheila Nazari, Karim Faez
Hyper-synchronous neural oscillations are the character of several neurological diseases such as epilepsy. On the other hand, glial cells and particularly astrocytes can influence neural synchronization. Therefore, based on the recent researches, a new bio-inspired stimulator is proposed which basically is a dynamical model of the astrocyte biophysical model. The performance of the new stimulator is investigated on a large-scale, cortical network. Both excitatory and inhibitory synapses are also considered in the simulated spiking neural network...
September 13, 2016: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/27516384/comparing-neurostimulation-technologies-in-refractory-focal-onset-epilepsy
#16
REVIEW
Inuka Kishara Gooneratne, Alexander L Green, Patricia Dugan, Arjune Sen, Angelo Franzini, Tipu Aziz, Binith Cheeran
For patients with pharmacoresistant focal epilepsy in whom surgical resection of the epileptogenic focus fails or was not feasible in the first place, there were few therapeutic options. Increasingly, neurostimulation provides an alternative treatment strategy for these patients. Vagal nerve stimulation (VNS) is well established. Deep brain stimulation (DBS) and cortical responsive stimulation (CRS) are newer neurostimulation therapies with recently published long-term efficacy and safety data. In this literature review, we introduce these therapies to a non-specialist audience...
November 2016: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/27485172/thalamic-interictal-epileptiform-discharges-in-deep-brain%C3%A2-stimulated-epilepsy-patients
#17
Catherine M Sweeney-Reed, Harim Lee, Stefan Rampp, Tino Zaehle, Lars Buentjen, Juergen Voges, Martin Holtkamp, Hermann Hinrichs, Hans-Jochen Heinze, Friedhelm C Schmitt
The relationships between interictal epileptiform discharges (IEDs) in the anterior (ANT) and dorsomedial nuclei (DMNT) of the thalamus and electro-clinical parameters in pharmacoresistant focal epilepsy patients receiving intrathalamic electrodes for deep brain stimulation (DBS) were investigated. Thalamus-localized IEDs (LIEDs) and surface EEG (sEEG)-IEDs were evaluated in eight patients who underwent ANT-DBS. Occurrence and frequency of ANT- and DMNT-LIEDs and pre-operative sEEG-IEDs were examined with respect to seizure onset location and seizure outcome following ANT-DBS...
October 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27434073/clinical-outcome-of-patients-with-deep-brain-stimulation-of-the-centromedian-thalamic-nucleus-for-refractory-epilepsy-and-location-of-the-active-contacts
#18
Byung-Chul Son, Young Min Shon, Jin-Gyu Choi, Jiyeon Kim, Sang-Woo Ha, Sung-Hoon Kim, Si-Hoon Lee
OBJECTIVES: To investigate the clinical outcome of patients treated with chronic deep brain stimulation (DBS) of the centromedian nucleus (CM) for refractory epilepsy and to determine the location of active contacts. METHODS: The outcome of CM stimulation was evaluated as percent seizure reduction compared to the baseline 3 months. To establish the location of active contacts, 27 leads were studied in 14 patients with refractory epilepsy. An analysis was conducted to reveal whether any coordinates of the center of the active contacts predicted percent seizure reduction...
2016: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/27398710/imaging-of-anterior-nucleus-of-thalamus-using-1-5t-mri-for-deep-brain-stimulation-targeting-in-refractory-epilepsy
#19
Elena Jiltsova, Timo Möttönen, Markus Fahlström, Joonas Haapasalo, Timo Tähtinen, Jukka Peltola, Juha Öhman, Elna-Marie Larsson, Tommi Kiekara, Kai Lehtimäki
BACKGROUND: Deep brain stimulation (DBS) of the anterior nucleus of thalamus (ANT) is an evolving treatment option in refractory focal epilepsy. Due to poor visualization of ANT in traditional MRI sequences used for movement disorder surgery, targeting of ANT is mainly based on stereotactic atlas information. Sophisticated 3T MRI methods enable visualization of ANT, but 1.5T MRI is still preferred or more readily available in a large number of centers performing DBS. OBJECTIVE: In the present study, we sought to determine whether ANT could be adequately visualized at 1...
December 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27322347/modern-management-of-seizures-and-epilepsy
#20
REVIEW
Markus Gschwind, Margitta Seeck
Complete seizure control is achieved in 40-50% of all epileptic patients with drug treatment, as reported in most epidemiological studies. Many effective antiepileptic drugs with a favourable profile are available in Switzerland, allowing treatment tailored to the patient's needs. Unfortunately, up to 40-50% of all patients will eventually relapse (pharmacoresistant epilepsy). These patients run a high risk of additional morbidity and mortality. Possible pharmacoresistant epilepsy should be considered early in the disease, when there is a lack of response to the first antiepileptic drug, since only 14% of those will respond to a second drug, and only 2% to a third drug if the second fails too...
2016: Swiss Medical Weekly
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