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MUC1 DIABETES

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https://www.readbyqxmd.com/read/26870234/costimulation-with-anti-cluster-of-differentiation-3-and-anti-cluster-of-differentiation-28-reduces-the-activity-of-mucin-1-stimulated-human-mononuclear-cells
#1
Stephen E Wright, Kathleen A Rewers-Felkins, Imelda Quinlin, Fatema Zohra, Jewel Ahmed
Cytotoxic T-lymphocyte activation and extension of the cell life span is necessary in order to enable immunotherapy to perform effectively against cancer. In the present study, mucin 1 (MUC1)-stimulated human mononuclear cells (M1SHMCs) were costimulated with bead-attached monoclonal antibodies specific for cluster of differentiation (CD)3 and CD28 receptors. The study was undertaken to determine whether costimulation was capable of enhancing the killing of cancer cells in vitro and of protecting non-obese diabetic severe combined immunodeficient mice from tumor development...
January 2016: Oncology Letters
https://www.readbyqxmd.com/read/25364765/cardio-mirnas-and-onco-mirnas-circulating-mirna-based-diagnostics-for-non-cancerous-and-cancerous-diseases
#2
REVIEW
Masaru Katoh
Cardiovascular diseases and cancers are the leading causes of morbidity and mortality in the world. MicroRNAs (miRNAs) are short non-coding RNAs that primarily repress target mRNAs. Here, miR-24, miR-125b, miR-195, and miR-214 were selected as representative cardio-miRs that are upregulated in human heart failure. To bridge the gap between miRNA studies in cardiology and oncology, the targets and functions of these miRNAs in cardiovascular diseases and cancers will be reviewed. ACVR1B, BCL2, BIM, eNOS, FGFR3, JPH2, MEN1, MYC, p16, and ST7L are miR-24 targets that have been experimentally validated in human cells...
2014: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/24553122/acquired-resistance-to-metformin-in-breast-cancer-cells-triggers-transcriptome-reprogramming-toward-a-degradome-related-metastatic-stem-like-profile
#3
Cristina Oliveras-Ferraros, Alejandro Vazquez-Martin, Elisabet Cuyàs, Bruna Corominas-Faja, Esther Rodríguez-Gallego, Salvador Fernández-Arroyo, Begoña Martin-Castillo, Jorge Joven, Javier A Menendez
Therapeutic interventions based on metabolic inhibitor-based therapies are expected to be less prone to acquired resistance. However, there has not been any study assessing the possibility that the targeting of the tumor cell metabolism may result in unforeseeable resistance. We recently established a pre-clinical model of estrogen-dependent MCF-7 breast cancer cells that were chronically adapted to grow (> 10 months) in the presence of graded, millimolar concentrations of the anti-diabetic biguanide metformin, an AMPK agonist/mTOR inhibitor that has been evaluated in multiple in vitro and in vivo cancer studies and is now being tested in clinical trials...
2014: Cell Cycle
https://www.readbyqxmd.com/read/24303799/tucaresol-down-modulation-of-muc1-stimulated-human-mononuclear-cells
#4
Stephen E Wright, Kathleen A Rewers-Felkins, Nazrul I Chowdhury, Jewel Ahmed, Sanjay K Srivastava, Pamela R Lockwood-Cooke
Interaction between antigen presenting cells and T lymphocytes, through receptors and co-stimulatory molecules present on the surface of these cells, is one of the key means to modulate the adaptive immune system. Tucaresol, a Schiff-base-forming chemical, can be used as a substitute for the physiological donor of carbonyl groups of antigen presenting cells, which can interact with the amine groups of T lymphocytes to modulate the adaptive immune system. This study was done to determine whether tucaresol can enhance killing of cancer cells in vitro as well as protect non-obese diabetic severe combined immunodeficient mice from tumor development by mucin 1 stimulated human mononuclear cells through the adaptive immune system...
2014: Immunological Investigations
https://www.readbyqxmd.com/read/22539679/endometrial-receptivity-defects-and-impaired-implantation-in-diabetic-nod-mice
#5
Ahmad J H Albaghdadi, Frederick W K Kan
Implantation failure is a major hurdle to a successful pregnancy. The high rate of postimplantation fetal loss in nonobese diabetic (NOD) mice is believed to be related to an abnormal decidual production of interferon (IFN)gamma. To address whether diabetes alters the natural events associated with successful implantation, certain morphological and molecular features of uterine receptivity in diabetic NOD (dNOD) mice were examined in normally mated pregnancy and in concanavalin A (ConA)-induced pseudopregnancy...
August 2012: Biology of Reproduction
https://www.readbyqxmd.com/read/22076171/small-oncocytic-papillary-renal-cell-carcinoma-in-diabetic-glomerulosclerosis
#6
Tadashi Terada
Histologic and immunohistochemical features of oncocytic papillary renal cell carcinoma (RCC) have not been fully elucidated. The author herein report a case of oncocytic papillary RCC (OPRCC). A 71-year-old man with diabetes mellitus and diabetic nephropathy was found to have a small right renal tumor by CT. He had been treated with hemodialysis for chronic renal failure for 10 years. A nephrectomy was performed. Grossly, a small (1.5cm) encapsulated yellow tumor was found in the kidney. Histologically, the tumor was completely encapsulated, and consisted entirely of atypical oncocytes arranged in a diffuse papillary structure with fibrovascular cores...
2011: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/20406885/muc1-regulates-nuclear-localization-and-function-of-the-epidermal-growth-factor-receptor
#7
Benjamin G Bitler, Aarthi Goverdhan, Joyce A Schroeder
Alteration of protein trafficking and localization is associated with several diseases, including cystic fibrosis, breast cancer, colorectal cancer, leukemia and diabetes. Specifically, aberrant nuclear localization of the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase, is a poor prognostic indicator in several epithelial carcinomas. It is now appreciated that in addition to signaling from the plasma membrane, EGFR also trafficks to the nucleus, and can directly bind the promoter regions of genes encoding cyclin D1 (CCND1) and B-Myb (MYBL2)...
May 15, 2010: Journal of Cell Science
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