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TLR4 KIDNEY

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https://www.readbyqxmd.com/read/27916733/sirt1-regulates-lipopolysaccharide-induced-cd40-expression-in-renal-medullary-collecting-duct-cells-by-suppressing-the-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway
#1
Qin-Qin Lin, Yuan-Wen Geng, Zhong-Wei Jiang, Zhen-Jun Tian
AIMS: Recent evidence indicates that sirtuin1 (SIRT1), a NAD(+)-dependent deacetylase, exerts a protective effect against inflammatory kidney injury by suppressing pro-inflammatory cytokines production. The co-stimulatory molecule, CD40, is expressed in a variety of inflammatory diseases in the kidney. Here, we aimed to investigate the potential effect of SIRT1 on CD40 expression induced by lipopolysaccharide (LPS) and to disclose the underlying mechanisms in renal inner medullary collecting duct (IMCD) cells...
December 1, 2016: Life Sciences
https://www.readbyqxmd.com/read/27916228/corrigendum-to-tenuigenin-exhibits-protective-effects-against-lps-induced-acute-kidney-injury-via-inhibiting-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway-eur-j-pharmacol-791-2016-229-234
#2
Fu Haiyan, Hu Zhansheng, Di Xingwei, Zhang Qiuhong, Zhou Rongbin, Du Hongyang
No abstract text is available yet for this article.
December 5, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27897392/toll-like-receptor-4-signalling-mediates-inflammation-in-skeletal-muscle-of-patients-with-chronic-kidney-disease
#3
Daniela Verzola, Alice Bonanni, Antonella Sofia, Fabrizio Montecucco, Elena D'Amato, Valeria Cademartori, Emanuele Luigi Parodi, Francesca Viazzi, Chiara Venturelli, Giuliano Brunori, Giacomo Garibotto
BACKGROUND: Inflammation in skeletal muscle is implicated in the pathogenesis of insulin resistance and cachexia but why uremia up-regulates pro-inflammatory cytokines is unknown. Toll-like receptors (TLRs) regulate locally the innate immune responses, but it is unknown whether in chronic kidney disease (CKD) TLR4 muscle signalling is altered. The aim of the study is to investigate whether in CKD muscle, TLRs had abnormal function and may be involved in transcription of pro-inflammatory cytokine...
October 18, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27877060/anti-inflammatory-and-immunomodulatory-effects-of-aquaphilus-dolomiae-extract-on-in-vitro-models
#4
Marie-Françoise Aries, Hélène Hernandez-Pigeon, Clémence Vaissière, Hélène Delga, Antony Caruana, Marguerite Lévêque, Muriel Bourrain, Katia Ravard Helffer, Bertrand Chol, Thien Nguyen, Sandrine Bessou-Touya, Nathalie Castex-Rizzi
BACKGROUND: Atopic dermatitis (AD) is a common skin disease characterized by recurrent pruritic inflammatory skin lesions resulting from structural and immune defects of the skin barrier. Previous studies have shown the clinical efficacy of Avène thermal spring water in AD, and a new microorganism, Aquaphilus dolomiae was suspected to contribute to these unique properties. The present study evaluated the anti-inflammatory, antipruritic, and immunomodulatory properties of ES0, an original biological extract of A...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27829992/hmgb1-tlr4-signaling-participates-in-renal-ischemia-reperfusion-injury-and-could-be-attenuated-by-dexamethasone-mediated-inhibition-of-the-erk-nf-%C3%AE%C2%BAb-pathway
#5
Jiong Zhang, Jumei Xia, Ying Zhang, Fang Xiao, Jin Wang, Hongyu Gao, Yanyan Liu, Song Rong, Ying Yao, Gang Xu, Junhua Li
Studies have shown that the HMGB1-TLR4 (High-mobility group protein B1, toll-like receptor 4) pathway participates in renal ischemic reperfusion injury (IRI) and that dexamethasone (DEX) could protect the kidney against IRI. This study aims to examine the protective effects of DEX on renal IRI and further explore the possible mechanism of action. During mouse renal IRI, HMGB1-TLR4 signals changed markedly including HMGB1 translocation and TLR4 up-regulation, resulting in histological damage and an increase in MPO expression...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27829421/bovine-lactoferrin-free-of-lipopolysaccharide-can-induce-a-proinflammatory-response-of-macrophages
#6
Nada Zemankova, Katarina Chlebova, Jan Matiasovic, Jana Prodelalova, Jan Gebauer, Martin Faldyna
BACKGROUND: Lactoferrin (LF) is an 80 kDa glycoprotein which is known for its effects against bacteria, viruses and other pathogens. It also has a high potential in nutrition therapy and welfare of people and a variety of animals, including piglets. The ability to bind lipopolysaccharide (LPS) is one of the described anti-inflammatory mechanisms of LF. Previous studies suggested that cells can be stimulated even by LPS-free LF. Therefore, the aim of our study was to bring additional information about this possibility...
November 10, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27813491/hyperin-protects-against-lps-induced-acute-kidney-injury-by-inhibiting-tlr4-and-nlrp3-signaling-pathways
#7
Gong Chunzhi, Li Zunfeng, Qin Chengwei, Bu Xiangmei, Yu Jingui
Hyperin is a flavonoid compound derived from Ericaceae, Guttifera, and Celastraceae that has been shown to have various biological effects, such as anti-inflammatory and anti-oxidant effects. However, there is no evidence to show the protective effects of hyperin on lipopolysaccharide (LPS)-induced acute kidney injury (AKI). Therefore, we investigated the protective effects and mechanism of hyperin on LPS-induced AKI in mice. The levels of TNF-α, IL-6, and IL-1β were tested by ELISA. The effects of hyperin on blood urea nitrogen (BUN) and serum creatinine were also detected...
November 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27690015/gspe-inhibits-hmgb1-release-attenuating-renal-ir-induced-acute-renal-injury-and-chronic-renal-fibrosis
#8
Juan Zhan, Kun Wang, Conghui Zhang, Chunxiu Zhang, Yueqiang Li, Ying Zhang, Xiaoyan Chang, Qiaodan Zhou, Ying Yao, Yanyan Liu, Gang Xu
Grape seed proanthocyanindin extract (GSPE) is a polyphenolic bioflavonoid derived from grape seeds and has been widely studied for its potent antioxidant, anti-inflammatory and antitumor activities. HMGB1 is a newly discovered danger-associated molecular pattern (DAMP) that has potent proinflammatory effects once released by necrotic cells. However, the effect of GSPE on the HMGB1, and the relationship of those two with acute kidney injury and chronic kidney fibrosis are unknown. This study aimed to investigate the impact of GSPE on acute kidney injury and chronic fibrosis...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27648011/genetic-variants-in-toll-like-receptor-4-gene-and-their-association-analysis-with-estimated-glomerular-filtration-rate-in-mexican-american-families
#9
Farook Thameem, Sobha Puppala, Vidya S Farook, Balakuntalam S Kasinath, John Blangero, Ravindranath Duggirala, Hanna E Abboud
BACKGROUND/AIM: Toll-like receptor 4 (TLR4) is one of the regulators of the innate immune response. Genetic variations in TLR4 have been associated with inflammatory diseases, including type 2 diabetes. However, to our knowledge, there are no reports on the role of variations in TLR4 in chronic kidney disease susceptibility. The objective of this study is to determine whether the genetic variants in TLR4 are associated with the estimated glomerular filtration rate (eGFR), a measure of renal function...
August 2016: Cardiorenal Medicine
https://www.readbyqxmd.com/read/27616759/il-1%C3%AE-promotes-tubulointerstitial-injury-in-%C3%A2-mpo-anca-associated-glomerulonephritis%C3%A2
#10
Manabu Tashiro, Yoshie Sasatomi, Renya Watanabe, Maho Watanabe, Katsuhisa Miyake, Yasuhiro Abe, Tetsuhiko Yasuno, Kenji Ito, Naoko Ueki, Aki Hamauchi, Ritsuya Noda, Satoshi Hisano, Hitoshi Nakashima
BACKGROUND: It is widely accepted that tubulointerstitial injury (TII) is caused by glomerular injury (GI) in glomerular diseases. Glomerular endocapillary inflammation may result in crescent formation and exuded protein leakage, which may induce TII in antineutrophil cytoplasmic antibody-associated glomerulonephritis (ANCAGN). However, some reports have indicated a glomerulonephritis-independent mechanism of TII in ANCAGN. The aim of this study was to determine the principle cytokines correlated with TII severity and to elucidate a characteristic mechanism for TII in ANCAGN...
October 2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27614743/clarithromycin-attenuates-the-expression-of-monocyte-chemoattractant-protein-1-by-activating-toll-like-receptor-4-in-human-mesangial-cells
#11
Koji Tsugawa, Tadaatsu Imaizumi, Shojiro Watanabe, Kazushi Tsuruga, Hidemi Yoshida, Hiroshi Tanaka
BACKGROUND: Signaling pathways induced by the activation of renal toll-like receptor 4 (TLR4) play a pivotal role in chronic kidney disease (CKD). Some recent studies suggested that clarithromycin (CAM), a 14-membered ring macrolide, exerts renoprotective effects by suppressing proinflammatory chemokines. However, its beneficial effects on signaling pathways through renal TLR4 activation are unknown. METHODS: Cultured human mesangial cells (MCs) were treated with lipopolysaccharide (LPS)...
September 10, 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/27602552/physiological-aspects-of-toll-like-receptor-4-activation-in-sepsis-induced-acute-kidney-injury
#12
S B Anderberg, T Luther, R Frithiof
Sepsis-induced acute kidney injury (SI-AKI) is common and associated with high mortality. Survivors are at increased risk of chronic kidney disease. The precise mechanism underlying SI-AKI is unknown, and no curative treatment exists. Toll-like receptor 4 (TLR4) activates the innate immune system in response to exogenous microbial products. The result is an inflammatory reaction aimed at clearing a potential infection. However, the consequence may also be organ dysfunction as the immune response can cause collateral damage to host tissue...
September 7, 2016: Acta Physiologica
https://www.readbyqxmd.com/read/27585667/tlr4-mediated-inflammation-is-a-key-pathogenic-event-leading-to-kidney-damage-and-fibrosis-in-cyclosporine-nephrotoxicity
#13
Cristian González-Guerrero, Pablo Cannata-Ortiz, Consuelo Guerri, Jesús Egido, Alberto Ortiz, Adrián M Ramos
Cyclosporine A (CsA) successfully prevents allograft rejection, but nephrotoxicity is still a dose-limiting adverse effect. TLR4 activation promotes kidney damage but whether this innate immunity receptor mediates CsA nephrotoxicity is unknown. The in vivo role of TLR4 during CsA nephrotoxicity was studied in mice co-treated with CsA and the TLR4 inhibitor TAK242 and also in TLR4(-/-) mice. CsA-induced renal TLR4 expression in wild-type mice. Pharmacological or genetic targeting of TLR4 reduced the activation of proinflammatory signaling, including JNK/c-jun, JAK2/STAT3, IRE1α and NF-κB and the expression of Fn14...
September 1, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27578257/aging-increases-the-susceptibility-of-hepatic-inflammation-liver-fibrosis-and-aging-in-response-to-high-fat-diet-in-mice
#14
In Hee Kim, Jun Xu, Xiao Liu, Yukinori Koyama, Hsiao-Yen Ma, Karin Diggle, Young-Hyun You, Jan M Schilling, Dilip Jeste, Kumar Sharma, David A Brenner, Tatiana Kisseleva
We aimed to investigate whether aging increases the susceptibility of hepatic and renal inflammation or fibrosis in response to high-fat diet (HFD) and explore the underlying genetic alterations. Middle (10 months old) and old (20 months old) aged, male C57BL/6N mice were fed either a low-fat diet (4 % fat) or HFD (60 % fat) for 4 months. Young (3 months old) aged mice were included as control group. HFD-induced liver and kidney injuries were analyzed by serum and urine assay, histologic staining, immunohistochemistry, and reverse-transcription real-time quantitative polymerase chain reaction...
August 2016: Age (2005-)
https://www.readbyqxmd.com/read/27578035/vitamin-d-attenuates-kidney-fibrosis-via-reducing-fibroblast-expansion-inflammation-and-epithelial-cell-apoptosis
#15
Nur Arfian, Khusnul Muflikhah, Sri Kadarsih Soeyono, Dwi Cahyani Ratna Sari, Untung Tranggono, Nungki Anggorowati, Muhammad Mansyur Romi
Kidney fibrosis is the common final pathway of chronic kidney diseases (CKD). It is characterized by myofibroblast formation, inflammation, and epithelial architecture damage. Vitamin D is known as a renoprotective agent, although the precise mechanism is not well understood. This study aimed to elucidate the effect of vitamin D in fibroblast expansion, inflammation, and apoptosis in kidney fibrosis. We performed unilateral ureteral obstruction (UUO) in male Swiss-Webster background mice (3 months, 30-40 grams) to induce kidney fibrosis...
2016: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/27546562/tenuigenin-exhibits-protective-effects-against-lps-induced-acute-kidney-injury-via-inhibiting-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway
#16
Haiyan Fu, Zhansheng Hu, Xingwei Di, Qiuhong Zhang, Rongbin Zhou, Hongyang Du
Tenuigenin (TNG) has been reported to have various pharmacological activities, such as anti-oxidative and anti-inflammatory activities. However, the protective effects of TNG on lipopolysaccharides (LPS)-induced acute kidney injury (AKI) are still not clear. The aim of this study was to investigate the protective effects and mechanism of TGN on LPS-induced AKI in mice. The kidney histological change, levels of blood urea nitrogen (BUN), and creatinine were measured to assess the protective effects of TNG on LPS-induced AKI...
August 18, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27510583/toll%C3%A2-like-receptor-4-contributes-to-acute-kidney-injury-after-cardiopulmonary-resuscitation-in-mice
#17
Qingsong Zhang, Gang Li, Li Xu, Qian Li, Qianyan Wang, Yue Zhang, Qing Zhang, Peng Sun
Toll-like receptor 4 (TLR4) activation mediates renal injury in regional ischemia and reperfusion (I/R) models generated by clamping renal pedicles. However, it remains unclear whether TLR4 is causal in the kidney injury following global I/R induced by cardiac arrest (CA) and cardiopulmonary resuscitation (CPR). The present study used wild‑type (C3H/HeN) and TLR4‑mutant (C3H/HeJ) mice to produce the CA/CPR model. CA was induced by injection of cold KCl and left untreated for different time periods. After resuscitation (72 h), the level of blood urea nitrogen (BUN) and serum creatinine (Scr), as well as histological changes in renal tissue were assessed to evaluate the severity of acute kidney injury (AKI)...
October 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27510383/renoprotective-effects-of-a-highly-selective-a3-adenosine-receptor-antagonist-in-a-mouse-model-of-adriamycin-induced-nephropathy
#18
Hye Sook Min, Jin Joo Cha, Kitae Kim, Jung Eun Kim, Jung Yeon Ghee, Hyunwook Kim, Ji Eun Lee, Jee Young Han, Lak Shin Jeong, Dae Ryong Cha, Young Sun Kang
The concentration of adenosine in the normal kidney increases markedly during renal hypoxia, ischemia, and inflammation. A recent study reported that an A3 adenosine receptor (A3AR) antagonist attenuated the progression of renal fibrosis. The adriamycin (ADX)-induced nephropathy model induces podocyte injury, which results in severe proteinuria and progressive glomerulosclerosis. In this study, we investigated the preventive effect of a highly selective A3AR antagonist (LJ1888) in ADX-induced nephropathy. Three groups of six-week-old Balb/c mice were treated with ADX (11 mg/kg) for four weeks and LJ1888 (10 mg/kg) for two weeks as following: 1) control; 2) ADX; and 3) ADX + LJ1888...
September 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27496439/lowering-of-messenger-ribonucleic-acid-toll-like-receptors-2-4-9-in%C3%A2-peripheral-blood-mononuclear-cells-in-kidney-allograft-recipients-relationships-with-immunosuppressive-treatment-and-delayed-graft-function-occurrence
#19
S C Zmonarski, K Kościelska-Kasprzak, M Banasik, M Myszka, M Żabińska, K Madziarska, O Mazanowska, M Krajewska, M Boratyńska, M Klinger
BACKGROUND: Both tacrolimus (Tac) and cyclosporine (CsA) inhibit control peripheral blood mononuclear cells (PBMC) after stimulation of various Toll-like receptors (TLR) at supra-pharmacological concentrations. Earlier studies demonstrated that 24 hours after kidney transplantation (KT), the expression of the TLR4 messenger RNA (mRNA) in PBMC from patients with subsequent delayed graft function (DGF+) was lower than in patients without DGF (DGF-). An assessment was made of the interaction of immunosuppression with TLR mRNA in PBMC and to verify whether the reduced expression of TLR-2,3,4,9 mRNA in PBMC is permanent in DGF+...
June 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27458573/mycobacterium-leprae-activates-toll-like-receptor-4-signaling-and-expression-on-macrophages-depending-on-previous-bacillus-calmette-guerin-vaccination
#20
Anastasia Polycarpou, Martin J Holland, Ioannis Karageorgiou, Ayad Eddaoudi, Stephen L Walker, Sam Willcocks, Diana N J Lockwood
Toll-like receptor (TLR)-1 and TLR2 have been shown to be receptors for Mycobacterium leprae (M. leprae), yet it is unclear whether M. leprae can signal through alternative TLRs. Other mycobacterial species possess ligands for TLR4 and genetic association studies in human populations suggest that people with TLR4 polymorphisms may be protected against leprosy. Using human embryonic kidney (HEK)-293 cells co-transfected with TLR4, we demonstrate that M. leprae activates TLR4. We used human macrophages to show that M...
2016: Frontiers in Cellular and Infection Microbiology
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