Read by QxMD icon Read


Shihua Zhang, Liang Zhang, Yijun Wang, Jian Yang, Mingzhi Liao, Shoudong Bi, Zhongwen Xie, Chi-Tang Ho, Xiaochun Wan
Tea is one of the most popular non-alcoholic beverages consumed worldwide. Numerous bioactive constituents of tea were confirmed to possess healthy benefits via the mechanisms of regulating gene expressions or protein activities. However, a complete interacting profile between tea bioactive compounds (TBCs) and their target genes is lacking, which put an obstacle in the study of healthy function of tea. To fill this gap, we developed a database of target genes of TBCs (TBC2target, based on a pharmacophore mapping approach...
2018: Frontiers in Plant Science
Jun-Hui Chen, Pei-Pei Li, Li-Kun Yang, Lei Chen, Jie Zhu, Xu Hu, Yu-Hai Wang
OBJECTIVE: This study investigated the clinical efficacy of and optimal therapeutic strategy for ventricular intracranial pressure monitoring (V-ICPM) in patients with traumatic bifrontal contusions (TBCs). METHODS: From 8760 patients with a traumatic brain injury treated between January 2010 and January 2016, a retrospective analysis was performed on 105 patients with TBC who underwent V-ICPM and 282 TBC patients who did not. All patients underwent treatment at the 101st Hospital of the Chinese People's Liberation Army (Wuxi, China)...
February 28, 2018: World Neurosurgery
Saed Ramzi, Elaine L Hyett, Abigail S Wheal, Peter J Cant
True invasive tubular breast carcinoma (TBC) is unlikely to metastasize to axillary nodes, yet it is routinely subjected to sentinel lymph node biopsy (SLNB), even if the diagnosis was suspected preoperatively. The positive predictive value (PPV) of core biopsy for TBC and the incidence and predictors of axillary metastasis in invasive breast carcinomas identified as tubular-rich on core biopsy are unknown. Prospective patient and tumor data regarding postoperatively confirmed TBCs, and tubular-rich carcinoma identified on preoperative core biopsy between January 2005 and May 2016 was analyzed retrospectively...
February 24, 2018: Breast Journal
Ye-Jin Park, Hye-Min Lee, MinJung Shin, Mariadhas Valan Arasu, Doug Young Chung, Naif Abdullah Al-Dhabi, Sun-Ju Kim
Kale ( Brassica oleracea L. Acephala Group) is the rich source of medicinal value sulphur compounds, glucosinolates (GLSs). The aim of this study was to investigate the effect of different proportion of sulphur (S) supplementation levels on the accumulation of GLSs in the leaves of the kale cultivar ('TBC'). High performance liquid chromatography (HPLC) separation method guided to identify and quantify six GSLs including three aliphatic (progoitrin, sinigrin and gluconapin) and three indolyl (glucobrassicin, 4-methoxyglucobrassicin and neoglucobrasscin) respectively...
February 2018: Saudi Journal of Biological Sciences
Chuanling Jiang, Yawen Bang, Xinhao Wang, Xuefeng Lu, Zhenglong Lim, Haipeng Wei, Samir El-Hankari, Jishan Wu, Zebing Zeng
Open-shell π-conjugated compounds have recently received intense attention due to their unique properties and promising applications in materials science. However, the experiments on how the substituents affect their chemical bonding and structural motif remain less addressed. In this work, a series of tetrabenzo-Chichibabin's hydrocarbon (TBC) derivatives substituted by different electron-donating or -withdrawing groups at the termini were synthesized. The substituent effect was studied via X-ray crystallographic analysis...
February 19, 2018: Chemical Communications: Chem Comm
Isadora Orlando de Oliveira, Rodrigo Antunes de Vasconcelos, Bruna Pilz, Paulo Eduardo Portes Teixeira, Eduarda de Faria Ferreira, Wilson Mello, Débora Bevilaqua Grossi
Objectives: To observe the distribution of patients who presented with low back pain (LBP) and to determine the between therapists' interrater reliability of assessments in a private outpatient setting using treatment-based classification (TBC) subgroups. Methods: An observational and methodological study was conducted. Four hundred and twenty-nine patients (231 male; 198 female) presenting LBP symptoms and referred to conservative treatment were assessed by 13 physical therapists who conducted a 60-min examination process utilizing TBC subgroups...
February 2018: Journal of Manual & Manipulative Therapy
Novel N Chegou, Jayne S Sutherland, Anna-Ritah Namuganga, Paul Lam Corstjens, Annemieke Geluk, Gebremedhin Gebremichael, Joseph Mendy, Stephanus Malherbe, Kim Stanley, Gian D van der Spuy, Magdalena Kriel, Andre G Loxton, Belinda Kriel, Felanji Simukonda, Yonas Bekele, Jacob A Sheehama, Josefina Nelongo, Marieta van der Vyver, Atsbeha Gebrexabher, Habteyes Hailu, Maria M Esterhuyse, Ida Rosenkrands, Claus Aagard, Martin Kidd, Desta Kassa, Adane Mihret, Rawleigh Howe, Jacqueline M Cliff, Amelia C Crampin, Harriet Mayanja-Kizza, Stefan H E Kaufmann, Hazel M Dockrell, Tom H M Ottenhoff, Gerhard Walzl
We investigated host-derived biomarkers that were previously identified in QuantiFERON supernatants, in a large pan-African study. We recruited individuals presenting with symptoms of pulmonary TB at seven peripheral healthcare facilities in six African countries, prior to assessment for TB disease. We then evaluated the concentrations of 12 biomarkers in stored QuantiFERON supernatants using the Luminex platform. Based on laboratory, clinical and radiological findings and a pre-established algorithm, participants were classified as TB disease or other respiratory diseases(ORD)...
February 8, 2018: Scientific Reports
Marat I Kamalov, Trinh Đặng, Natalia V Petrova, Alexander V Laikov, Duong Luong, Rezeda A Akhmadishina, Andrei N Lukashkin, Timur I Abdullin
A new self-assembled formulation of methylprednisolone succinate (MPS) based on a carboxylated trifunctional block copolymer of ethylene oxide and propylene oxide (TBC-COOH) was developed. TBC-COOH and MPS associated spontaneously at increased concentrations in aqueous solutions to form almost monodisperse mixed micelles (TBC-COOH/MPS) with a hydrodynamic diameter of 19.6 nm, zeta potential of -27.8 mV and optimal weight ratio ∼1:6.3. Conditions for the effective formation of TBC-COOH/MPS were elucidated by comparing copolymers and glucocorticoids with different structure...
January 11, 2018: Colloids and Surfaces. B, Biointerfaces
Meng-Ting Shi, Ying Zhang, Gang-Qiao Zhou
The Tre-2/Bub2/Cdc16 (TBC) domain is a conserved protein motif consisting of approximately 200 amino acids, and is present in many eukaryotic proteins. TBC domain-containing proteins (TBC proteins) function as GTPase activating proteins (GAPs) for the small GTPase Rab, which can promote the hydrolysis of Rab-GTP to Rab-GDP in regulation of specific intracellular trafficking pathways. Several TBC proteins play important roles in cellular functions in mammals, and defects of which are closely associated with numerous disease processes...
January 20, 2018: Yi Chuan, Hereditas
Huiming Cao, Xun Li, Wenjuan Zhang, Ling Wang, Yu Pan, Zhen Zhou, Minjie Chen, Aiqian Zhang, Yong Liang, Maoyong Song
As a potential endocrine disruptor, tris(2,3-dibromopropyl) isocyanurate (TBC) has previously been demonstrated to reduce expression of estrogen-dependent vitellogenin (vtg) mRNA in adult zebrafish. However, the underlying toxicity pathways and molecular mechanisms involved in TBC-induced endocrine disruption remain elusive. In the current study, E-Screen and MVLN assays were employed to explore the potential anti-estrogenic effects of TBC via the estrogen receptor α (ERα)-mediated signaling pathway. Within a dose range between 1 × 10- 9 and 1 × 10- 7 M, TBC significantly inhibited 17β-estradiol (E2)-induced cell proliferation in a breast cancer cell line...
January 22, 2018: Archives of Toxicology
Pyae Phyo Wai, Hemant Deepak Shewade, Nang Thu Thu Kyaw, Khine Wut Yee Kyaw, Saw Thein, Aung Si Thu, Myo Minn Oo, Pyae Sone Htwe, Moe Myint Theingi Tun, Htet Myet Win Maung, Kyaw Thu Soe, Si Thu Aung
BACKGROUND: The community-based MDR-TB care (CBMDR-TBC) project was implemented in 2015 by The Union in collaboration with national TB programme (NTP) in 33 townships of upper Myanmar to improve treatment outcomes among patients with MDR-TB registered under NTP. They received community-based support through the project staff, in addition to the routine domiciliary care provided by NTP staff. Each project township had a project nurse exclusively for MDR-TB and a community volunteer who provided evening directly observed therapy (in addition to morning directly observed therapy by NTP)...
2017: PloS One
Daniel Gräfe, Matthias Gutberlet, Meinhard Mende, Ingo Dähnert, Christian Lücke, Martin Kostelka, Stefan Nitzsche, Janine Hoffmann, Matthias Grothoff
PURPOSE: Dilatation of the thoracic aorta is a well-known finding in corrected Tetralogy of Fallot. Complications are rare but can be life-threatening. Standard 1-dimensional (1D) measurements have several limitations. We sought to establish contrast-enhanced magnetic resonance angiography cross-sectional areas of the aorta that could serve as reference values and to identify parameters that are associated with aortic dilatation. MATERIALS AND METHODS: We enrolled 101 children and adolescents...
March 2018: Journal of Thoracic Imaging
Minjie Chen, Jie Zhang, Shaochen Pang, Chang Wang, Ling Wang, Yonghua Sun, Maoyong Song, Yong Liang
By measuring the vitellogenin 1 (vtg1) expression through quantitative PCR and in situ hybridization, we used the zebrafish embryo as an in vivo model to access the estrogenic or anti-estrogenic effects of several endocrine disrupting chemicals (EDCs), such as natural estrogen 17β-estradiol (E2), estriol (E3), synthetic hormones including diethylstilbestrol (DES), 4-octyl phenol (OP), bisphenol A (BPA), tamoxifen (TMX) and 3-(2,3-dibromopropyl) isocyanurate (TBC). According to our data, the estrogenic effect of the tested chemicals was ranked as: DES>E2 >E3 >OP>BPA, which is consistent with various in vivo and in vitro models...
January 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
Kumar Nilesh, Aaditee V Vande, Shivsagar Tewary, K V Suresh
Traumatic bone cysts (TBCs) are uncommon intraosseous lesions, classified as pseudocysts because they lack an epithelial membrane lining. The etiology of a pseudocyst has not been determined. Various hypotheses have been put forward to explain its pathogenesis, of which the traumatic-hemorrhagic theory is the most commonly accepted. Minor trauma, insufficient to cause fracture or iatrogenic injury, is commonly implicated as the stimulus initiating cyst formation. A TBC presenting after jaw fracture has been rarely reported in the literature...
November 2017: General Dentistry
Mohamed E Abd El-Hack, Samir A Mahgoub, Mohamed M A Hussein, Islam M Saadeldin
Using antibiotics in poultry diets as growth promoters was reported to have harmful effects on consumers, so the current study was done to monitor the impact of dietary supplementation of antimicrobial black cumin oil (BCO) on carcass traits, growth performance, biochemical components, and ileal microbial populations of growing Japanese quails. Three hundred growing Japanese quails were used with three different treatments (0, 0.50, and 1.0 g BCO/g diet). Birds fed diet supplemented with 0.5 g BCO/kg diet showed significant increase in body weight comparing with the control and other treatment group...
October 27, 2017: Environmental Science and Pollution Research International
Hang Liu, Shimin Wang, Weijian Hang, Jinghu Gao, Wenjuan Zhang, Zihang Cheng, Chao Yang, Jun He, Jie Zhou, Juan Chen, Anbing Shi
RAB-10/Rab10 is a master regulator of endocytic recycling in epithelial cells. To better understand the regulation of RAB-10 activity, we sought to identify RAB-10(GDP)-interacting proteins. One novel RAB-10(GDP)-binding partner that we identified, LET-413, is the Caenorhabditis elegans homologue of Scrib/Erbin. Here, we focus on the mechanistic role of LET-413 in the regulation of RAB-10 within the C. elegans intestine. We show that LET-413 is a RAB-5 effector and colocalizes with RAB-10 on endosomes, and the overlap of LET-413 with RAB-10 is RAB-5 dependent...
October 27, 2017: Journal of Cell Biology
Eilam Yalon, Özgür Burak Aslan, Kirby K H Smithe, Connor J McClellan, Saurabh V Suryavanshi, Feng Xiong, Aditya Sood, Christopher M Neumann, Xiaoqing Xu, Kenneth E Goodson, Tony F Heinz, Eric Pop
The electrical and thermal behavior of nanoscale devices based on two-dimensional (2D) materials is often limited by their contacts and interfaces. Here we report the temperature-dependent thermal boundary conductance (TBC) of monolayer MoS2 with AlN and SiO2 , using Raman thermometry with laser-induced heating. The temperature-dependent optical absorption of the 2D material is crucial in such experiments, which we characterize here for the first time above room temperature. We obtain TBC ∼ 15 MW m-2 K-1 near room temperature, increasing as ∼ T0...
December 13, 2017: ACS Applied Materials & Interfaces
Santanu Das
GTP hydrolysis is indispensable to keep a living cell healthy. Nature has evolved so many enzymes to enhance the slow GTP hydrolysis. Rab GTPases are evolved to regulate vesicle trafficking. GTPase activating proteins (GAPs) accelerates their intrinsic slow GTP hydrolysis in order to maintain the sustainability between cellular events. Any malfunction/interference in this hydrolysis disrupts normal cellular events and causes severe diseases. In this study, GTP hydrolysis mechanism of Rab33B catalyzed by TBC-domain GAP protein Gyp1p has been decoded using extensive ab initio QM/MM metadynamics simulations...
October 12, 2017: Molecular Informatics
Hongye Zhang, Huihui Wen, Zhanwei Liu, Qi Zhang, Huimin Xie
Moiré technique is a powerful, important and effective tool for scientific research, from the nano-scale to the macro-scale, which is essentially the interference between two or more periodic structures with a similar frequency. In this study, an inverse transmission electron microscopy (TEM) nano-Moiré method has been proposed, for the first time, to reconstruct an invisible lattice structure near the grain interface, where only one kind of lattice structure and Moiré fringe were visible in a high resolution TEM (HRTEM) image simultaneously...
October 26, 2017: Nanoscale
Nicholas V Karayannis, Gwendolen A Jull, Michael K Nicholas, Paul W Hodges
OBJECTIVE: To determine the distribution of higher psychological risk features within movement-based subgroups for people with Low Back Pain (LBP) DESIGN: Cross-sectional observational study SETTING: Participants were recruited from physiotherapy clinics and community advertisements. Measures were collected at a university outpatient-based physiotherapy clinic. PARTICIPANTS: 102 people seeking treatment for LBP INTERVENTIONS: Participants were subgrouped according to three classification schemes: Mechanical Diagnosis and Treatment (MDT), Treatment Based Classification (TBC) and O'Sullivan Classification (OSC)...
October 5, 2017: Archives of Physical Medicine and Rehabilitation
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"