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Sarah Keller, Ryota Inai, Shuhei Sato, Akihiro Tada, Gerhard Adam, Jin Yamamura, Susumu Kanazawa
OBJECTIVE: The radiologic differential diagnosis of giant cell tumors (GCTs) is challenging because there is a risk of misdiagnosis of GCTs as malignant lesions such as atypically presenting osteosarcomas (OSs). This study aims to assess the feasibility of (201)Tl scintigraphy for the differential diagnosis of GCT and atypical OS. MATERIALS AND METHODS: Thallium-201 scintigraphy scans obtained between January 2006 and October 2015 of patients with histologically proven GCT (23 patients [male-to-female ratio, 15:8]; median age, 33...
October 11, 2016: AJR. American Journal of Roentgenology
Michael Scordo, Valkal Bhatt, Meier Hsu, Antonio M Omuro, Matthew J Matasar, Lisa M DeAngelis, Parastoo B Dahi, Craig H Moskowitz, Sergio A Giralt, Craig S Sauter
High-dose therapy and autologous stem cell transplantation (HDT-ASCT) with thiotepa, busulfan, cyclophosphamide (TBC) conditioning has emerged as an effective post-induction treatment strategy for patients with primary (PCNSL) or secondary central nervous system lymphoma (SCNSL), but it is associated with considerable toxicity and transplant-related mortality (TRM) in the modern era. Forty-three adult patients with chemosensitive PCNSL or SCNSL received TBC conditioned ASCT between 2006 and 2015. Twenty-eight of these patients received pharmacokinetically (PK)-targeted busulfan dosing...
October 3, 2016: Biology of Blood and Marrow Transplantation
Ryo Atsuta, Yasuo To, Susumu Sakamoto, Isao Mukai, Akihiro Kobayashi, Arisa Kinoshita, Kazuhisa Takahashi
BACKGROUND: Maintaining high treatment adherence levels is critical for effective management of chronic diseases. The Adherence Starts with Knowledge 20 (ASK-20) questionnaire is the only linguistically validated patient-reported treatment adherence tool available in Japan. We conducted additional analyses on ASK-20 data from Japanese adults with asthma. METHODS: This was a prospective, non-interventional, single-visit, multi-centre study in Japanese adults (n = 300) with asthma receiving long-term treatment with inhaled corticosteroids (ICS) or ICS/long-acting beta-agonists...
October 3, 2016: Allergology International: Official Journal of the Japanese Society of Allergology
Di Peng, Lixia Yang, Tao Cai, Yingzheng Liu, Xiaofeng Zhao, Zhiqi Yao
Yttria-stabilized zirconia (YSZ)-based thermal barrier coating (TBC) has been integrated with thermographic phosphors through air plasma spray (APS) for in-depth; non-contact temperature sensing. This coating consisted of a thin layer of Dy-doped YSZ (about 40 µm) on the bottom and a regular YSZ layer with a thickness up to 300 µm on top. A measurement system has been established; which included a portable; low-cost diode laser (405 nm); a photo-multiplier tube (PMT) and the related optics. Coating samples with different topcoat thickness were calibrated in a high-temperature furnace from room temperature to around 900 °C...
2016: Sensors
Baptiste Fischer, Kevin Lüthy, Jone Paesmans, Charlotte De Koninck, Ine Maes, Jef Swerts, Sabine Kuenen, Valerie Uytterhoeven, Patrik Verstreken, Wim Versées
Mutations in TBC1D24 cause severe epilepsy and DOORS syndrome, but the molecular mechanisms underlying these pathologies are unresolved. We solved the crystal structure of the TBC domain of the Drosophila ortholog Skywalker, revealing an unanticipated cationic pocket conserved among TBC1D24 homologs. Cocrystallization and biochemistry showed that this pocket binds phosphoinositides phosphorylated at the 4 and 5 positions. The most prevalent patient mutations affect the phosphoinositide-binding pocket and inhibit lipid binding...
September 26, 2016: Nature Structural & Molecular Biology
Kamonpun Ussavarungsi, Ryan M Kern, Anja C Roden, Jay H Ryu, Eric S Edell
BACKGROUND: Diagnostic evaluation of patients with diffuse parenchymal lung disease (DPLD) is best achieved by a multidisciplinary team correlating clinical, radiologic, and pathologic features. Surgical lung biopsies remain the gold standard for histopathologic diagnosis of idiopathic interstitial pneumonias. Emerging data suggest an increasing role for transbronchial cryobiopsy (TBC) in DPLD evaluation. We describe our experience with TBC in patients with DPLD. METHODS: We retrospectively reviewed medical records of patients with radiographic features of DPLD who underwent TBC at Mayo Clinic, Rochester, Minnesota in June 2013-September 2015...
September 19, 2016: Chest
Ling Wang, Mengyuan Zhang, Yinghua Lou, Runhui Ke, Minggang Zheng
The levels and distribution of tris-(2,3-dibromopropyl) isocyanurate (TBC) and hexabromocyclododecanes (HBCDs) of surface sediments in the Yellow River Delta wetland had been investigated. The concentrations of TBC and ∑HBCDs ranged from 0.20 to 29.03ng·g(-1)dw and below limits of detections (LODs) to 20.25ng·g(-1)dw. The average composition profile of three HBCDs isomers were 10.1%, 6.1% and 83.8% for α-, β- and γ-HBCD, respectively. Moreover, correlation analysis indicated there are similar sources among three isomers and positive correlations between total organic carbon (TOC) content and concentrations of TBC and HBCDs...
September 16, 2016: Marine Pollution Bulletin
Ntaote David Shooto, Charity Wokwu Dikio, Donbebe Wankasi, Lucky Mashudu Sikhwivhilu, Fanyana Moses Mtunzi, Ezekiel Dixon Dikio
Plain polyvinyl alcohol (PVA) nanofibres and novel polyvinyl alcohol benzene tetracarboxylate nanofibres incorporated with strontium, lanthanum and antimony ((PVA/Sr-TBC), (PVA/La-TBC) and (PVA/Sb-TBC)), respectively, where TBC is benzene 1,2,4,5-tetracarboxylate adsorbents, were fabricated by electrospinning. The as-prepared electrospun nanofibres were characterized by scanning electron microscope (SEM), Fourier transform infrared (FTIR) and thermogravimetric analysis (TGA). Only plain PVA nanofibres followed the Freundlich isotherm with a correlation coefficient of 0...
December 2016: Nanoscale Research Letters
Ioannis Panagopoulos, Ludmila Gorunova, Trond Viset, Sverre Heim
We present an angiofibroma of soft tissue with the karyotype 46,XY,t(4;5)(q24;q31),t(5;8;17)(p15;q13;q21)[8]/46,XY,t(1;14)(p31;q32)[2]/46,XY[3]. RNA‑sequencing showed that the t(4;5)(q24;q31) resulted in recombination of the genes TBCK on 4q24 and P4HA2 on 5q31.1 with generation of an in‑frame TBCK‑P4HA2 and the reciprocal but out‑of‑frame P4HA2‑TBCK fusion transcripts. The putative TBCK‑P4HA2 protein would contain the kinase, the rhodanese‑like domain, and the Tre‑2/Bub2/Cdc16 (TBC) domains of TBCK together with the P4HA2 protein which is a component of the prolyl 4‑hydroxylase...
September 15, 2016: Oncology Reports
Yusuke Mori, Kohgaku Eguchi, Kiyonori Yoshii, Yoshitaka Ohtubo
Each taste bud cell (TBC) type responds to a different taste. Previously, we showed that an unidentified cell type(s) functionally expresses a muscarinic acetylcholine (ACh) receptor subtype, M3, and we suggested the ACh-dependent modification of its taste responsiveness. In this study, we found that M3 is expressed by type III TBCs, which is the only cell type that possesses synaptic contacts with taste nerve fibers in taste buds. The application of ACh to the basolateral membrane of mouse fungiform TBCs in situ increased the intracellular Ca(2+) concentration in 2...
September 14, 2016: Pflügers Archiv: European Journal of Physiology
Alisdair R MacLeod, Hannah Rose, Harinderjit S Gill
For the first time, an experimentally validated finite element model of a composite femur is presented for use in the three solvers: ABAQUS (Simulia); ANSYS (ANSYS, Inc.) and FEBio (University of Utah). This model is freely available online [web address tbc] along with all supporting validation data. Synthetic biomechanical test specimens are frequently used for pre-clinical evaluation of implant performance, often in combination with numerical modelling such as Finite Element (FE) analysis. The primary aim of the study to conduct a comparison of mesh convergence and strain prediction between three solvers (ABAQUS, ANSYS and FEBio) and to provide validated open-source models of a fourth generation composite femur for use all three FE packages...
September 12, 2016: Journal of Biomechanical Engineering
Hyoung Keun Kim, Jae-Hyung Lim, Kug-Jin Jeon, Jong-Ki Huh
Traumatic bone cyst (TBC) occurs preferentially on the mandibular symphysis and body, but rarely on the mandibular condyle. When TBC occurs in the condylar area, it can usually be related with or misdiagnosed as a temporomandibular joint disorder. A 15-year-old female patient visited the Temporomandibular Joint Clinic with a 5-year history of pain and noise localized in the left temporomandibular joint. On imaging, a well demarked oval-shaped radiolucent lesion was observed on the left condyle head. The patient underwent cyst enucleation and repositioning of the bony window on the lateral cortex of the affected condyle head under the impression of subchondral cyst or TBC; however, no cystic membrane was found...
August 2016: Journal of the Korean Association of Oral and Maxillofacial Surgeons
Yudibeth Sixto-López, Martiniano Bello, Rolando Alberto Rodríguez-Fonseca, Martha Cecilia Rosales-Hernández, Marlet Martínez-Archundia, José Antonio Gómez-Vidal, José Correa-Basurto
HDAC are a family of proteins involved in the deacetylation of histones and other non-histones substrates. HDAC6 belong to class II and share similar biological functions with others of its class. Nevertheless, its three dimensional structure that involves the catalytic site remains unknown for explore the ligand recognition properties. Therefore, in this contribution, homology modeling, 100 ns-long Molecular Dynamics (MD) simulation and docking calculations were combined to explore the conformational complexity and binding properties of the catalytic domain 2 from HDAC6 (DD2-HDAC6), for which activity and affinity towards 5 different ligands has been reported...
September 2, 2016: Journal of Biomolecular Structure & Dynamics
Kuangda Lu, Chunbai He, Nining Guo, Christina Chan, Kaiyuan Ni, Ralph R Weichselbaum, Wenbin Lin
Photodynamic therapy (PDT) can destroy local tumors and minimize normal tissue damage, but is ineffective at eliminating metastases. Checkpoint blockade immunotherapy has enjoyed recent success in the clinic, but only elicits limited rates of systemic antitumor response for most cancers due to insufficient activation of the host immune system. Here we describe a treatment strategy that combines PDT by a new chlorin-based nanoscale metal-organic framework (nMOF), TBC-Hf, and a small-molecule immunotherapy agent that inhibits indoleamine 2,3-dioxygenase (IDO), encapsulated in the nMOF channels to induce systemic antitumor immunity...
September 28, 2016: Journal of the American Chemical Society
Jihen Ben Amar, Haifa Zaibi, Kehna Bouzid, Saloua Azzabi, Mohamed Ali Bacca, Besma Dahari, Hichem Aouina
BACKGROUND: Conventional biomarkers lack sensitivity and specificity for acute pulmonary Community (PAC). Procalcitonin (PCT) has been described in the literature for its usefulness in the PAC. The aim of our work was to study the contribution of the PCT in the positive diagnosis of PAC and in the initial assessment of the severity and the interest of CRP and PCT to distinguish lung infections from tuberculous origin of the PAC. METHODS: Prospective study of 100 middle-aged 45 years [16-82], admitted to our clinic for evaluation of lung opacity some of the reason for consultation...
March 2016: La Tunisie Médicale
Brenda Reiss-Brennan, Kimberly D Brunisholz, Carter Dredge, Pascal Briot, Kyle Grazier, Adam Wilcox, Lucy Savitz, Brent James
IMPORTANCE: The value of integrated team delivery models is not firmly established. OBJECTIVE: To evaluate the association of receiving primary care in integrated team-based care (TBC) practices vs traditional practice management (TPM) practices (usual care) with patient outcomes, health care utilization, and costs. DESIGN: A retrospective, longitudinal, cohort study to assess the association of integrating physical and mental health over time in TBC practices with patient outcomes and costs...
August 23, 2016: JAMA: the Journal of the American Medical Association
Ling Wang, Quansheng Zhao, Yanyan Zhao, Yinghua Lou, Minggang Zheng, Yue Yu, Mengyuan Zhang
The concentration and distribution of tris-(2,3-dibromopropyl) isocyanurate (TBC) and the three isomers of hexabromocyclododecane (HBCDs) were analyzed in the sediment of Jiaozhou Bay wetland in China. The concentrations of TBC and the three isomers of HBCDs (α-HBCD, β-HBCD, γ-HBCD) were in the ranges of 1.20 to 8.76, 1.03 to 5.69, 1.13 to 5.46, and 1.18 to 15.04ng·g(-1) dw (dry weight), respectively. γ-HBCD was the predominant congener with an average proportion of 52.42% of ΣHBCDs, average inventory of HBCDs was about 93...
August 16, 2016: Marine Pollution Bulletin
Nisar Ahmed, Huang Yufei, Ping Yang, Waqas Muhammad Yasir, Qian Zhang, Tengfei Liu, Chen Hong, Hu Lisi, Chu Xiaoya, Qiusheng Chen
Sertoli cells (SCs) play a central role in the development of germ cells within functional testes and exhibit varying morphology during spermatogenesis. This present study investigated the seasonal morphological changes in SCs in the reproductive cycle of Pelodiscus sinensis by light microscopy, transmission electron microscopy (TEM), and immunohistochemistry. During hibernation period with the quiescent of spermatogenesis, several autophagosomes were observed inside the SCs, the processes of which retracted...
June 2016: Ecology and Evolution
Theodore J D Knight-Jones, M Bernard Hang'ombe, Mwansa M Songe, Yona Sinkala, Delia Grace
A field study was performed to assess safety of smallholder fresh cow's milk around Mongu, Western Province, Zambia. This involved observation and sampling of milk along the value chain from milking to point-of-sale and storage. Samples were collected from 86 cows, from 9 farmers, selling through two dairy cooperatives, with additional samples from informal markets. Production was very low; around one litre/day/cow and 10 L/day/herd. The milk was typically transported by bicycle in high ambient temperatures without refrigeration until reaching the point-of-sale (journey times of 30-120 min), where it was sold without pasteurisation despite milk-borne zoonoses being endemic (bovine tuberculosis (bTB) and Brucellosis)...
2016: International Journal of Environmental Research and Public Health
Xiao Zhang, Yu Zhou, Qingfu Zhang, Victor C S Lee, Minming Li
Barrier coverage with wireless sensors aims at detecting intruders who attempt to cross a specific area, where wireless sensors are distributed remotely at random. This paper considers limited-power sensors with adjustable ranges deployed along a linear domain to form a barrier to detect intruding incidents. We introduce three objectives to minimize: 1) total power consumption while satisfying full coverage; 2) the number of active sensors to improve the reliability; and 3) the active sensor nodes' maximum sensing range to maintain fairness...
July 18, 2016: IEEE Transactions on Cybernetics
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