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https://www.readbyqxmd.com/read/28486663/ca2-signaling-machinery-is-present-at-intercellular-junctions-and-structures-associated-with-junction-turnover-in-rat-sertoli-cells
#1
Kevin Lyon, Arlo Adams, Matthew Piva, Parisa Asghari, Edwin D Moore, A Wayne Vogl
The endoplasmic reticulum (ER) is a prominent organelle in Sertoli cells. It is an integral component of unique adhesion junctions (ectoplasmic specializations-ESs) in this cell type, and is closely associated with structures termed tubulobulbar complexes (TBCs) that internalize intercellular junctions during sperm release and during the translocation of spermatocytes through the blood-testis barrier. A role for the ER in Ca2+ regulation at ESs and TBCs has been suspected, but evidence for this function has proved elusive...
May 8, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28486215/phonon-thermal-transport-in-silicene-germanene-superlattice-a-molecular-dynamics-study
#2
Xinyu Wang, Yang Hong, Paddy K L Chan, Jingchao Zhang
Two-dimensional (2D) hybrid materials have drawn enormous attentions in thermoelectric applications. In this work, we apply molecular dynamics (MD) simulation to investigate the phonon thermal transport in silicene-germanene superlattice. A non-monotonic thermal conductivity of silicene-germanene superlattice with period length is revealed, which is due to the coherent-incoherent phonon conversion and phonon confinement mechanisms. We also calculate the thermal conductivity of Si-Ge random mixing monolayer, showing a U-shaped trend...
May 9, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28469824/traction-test-of-temporary-dental-cements
#3
Juan-Luis Román-Rodríguez, Diego Millan-Martínez, Antonio Fons-Font, Rubén Agustín-Panadero, Lucía Fernández-Estevan
BACKGROUND: Classic self-curing temporary cements obstruct the translucence of provisional restorations. New dual-cure esthetic temporary cements need investigation and comparison with classic cements to ensure that they are equally retentive and provide adequate translucence. The objective is to analyze by means of traction testing in a in vitro study the retention of five temporary cements. MATERIAL AND METHODS: Ten molars were prepared and ten provisional resin restorations were fabricated using CAD-CAM technology (n=10)...
April 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28466854/increase-the-elongation-at-break-of-poly-lactic-acid-composites-for-use-in-food-packaging-films
#4
Ahmed M El-Hadi
Poly (3-hydroxy butyrate) (PHB), cellulose nano crystal (CNC) and a plasticizer (TBC) are mixed together with PLLA with the aim to increase the elongation at break for use in the food packing sector. Spherical (CNC) and fibril nano crystal (CNF) were prepared by hydrolysis of microcrystalline cellulose (MCC) in distilled water, and then stirred using a magnetic stirrer for 15 days and ultrasonic treatment without using any acids as green method. The morphology, thermal, and mechanical properties were studied using POM, DSC, WAXD, SEM and tensile testing, respectively...
May 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28455411/the-vps-34-pi3-kinase-negatively-regulates-rab-5-during-endosome-maturation
#5
Fiona Law, Jung Hwa Seo, Ziqing Wang, Jennifer L DeLeon, Yousstina Bolis, Ashley Brown, Wei-Xing Zong, Guangwei Du, Christian E Rocheleau
The Rab5 GTPase and phosphatidylinositol-3 phosphate (PI(3)P) coordinately regulate endosome trafficking. Rab5 recruits Vps34, the class III PI3-kinase (PI3K), to generate PI(3)P and recruit PI(3)P binding proteins. Loss of Rab5 and loss of Vps34 have opposite effects on endosome size suggesting that our understanding of how Rab5 and PI(3)P cooperate is incomplete. Here we report a novel regulatory loop, whereby C. elegans VPS-34 inactivates RAB-5 via recruitment of the TBC-2 Rab GTPase Activating Protein. We found that loss of VPS-34 caused a large late endosome phenotype like that of loss of TBC-2, and that Rab5 activity is increased in Vps34 knockout mouse embryonic fibroblasts...
April 28, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28434737/short-communication-microbiological-quality-of-raw-cow-milk-and-its-association-with-herd-management-practices-in-northern-china
#6
X Y Lan, S G Zhao, N Zheng, S L Li, Y D Zhang, H M Liu, J McKillip, J Q Wang
Contamination of raw milk with bacterial pathogens is potentially hazardous to human health. The aim of this study was to evaluate the total bacteria count (TBC) and presence of pathogens in raw milk in Northern China along with the associated herd management practices. A total of 160 raw milk samples were collected from 80 dairy herds in Northern China. All raw milk samples were analyzed for TBC and pathogens by culturing. The results showed that the number of raw milk samples with TBC <2 × 10(6) cfu/mL and <1 × 10(5) cfu/mL was 146 (91...
April 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28388845/energy-dissipation-in-monolayer-mos2-electronics
#7
Eilam Yalon, Connor J McClellan, Kirby K H Smithe, Miguel Muñoz Rojo, Runjie Lily Xu, Saurabh V Suryavanshi, Alex J Gabourie, Christopher M Neumann, Feng Xiong, Amir Barati Farimani, Eric Pop
The advancement of nanoscale electronics has been limited by energy dissipation challenges for over a decade. Such limitations could be particularly severe for two-dimensional (2D) semiconductors integrated with flexible substrates or multilayered processors, both being critical thermal bottlenecks. To shed light into fundamental aspects of this problem, here we report the first direct measurement of spatially resolved temperature in functioning 2D monolayer MoS2 transistors. Using Raman thermometry, we simultaneously obtain temperature maps of the device channel and its substrate...
May 2, 2017: Nano Letters
https://www.readbyqxmd.com/read/28384198/tbc1d12-is-a-novel-rab11-binding-protein-that-modulates-neurite-outgrowth-of-pc12-cells
#8
Mai E Oguchi, Kenta Noguchi, Mitsunori Fukuda
Recycling endosomes are generally thought to play a central role in endocytic recycling, but recent evidence has indicated that they also participate in other cellular events, including cytokinesis, autophagy, and neurite outgrowth. Rab small GTPases are key regulators in membrane trafficking, and although several Rab isoforms, e.g., Rab11, have been shown to regulate recycling endosomal trafficking, the precise mechanism by which these Rabs regulate recycling endosomes is not fully understood. In this study, we focused on a Rab-GTPase-activating protein (Rab-GAP), one of the key regulators of Rabs, and comprehensively screened 43 mammalian Tre-2/Bub2/Cdc16 (TBC)/Rab-GAP-domain-containing proteins (TBC proteins) for proteins that specifically localize on recycling endosomes in mouse embryonic fibroblasts (MEFs)...
2017: PloS One
https://www.readbyqxmd.com/read/28369839/high-dose-chemotherapy-with-thiotepa-busulfan-and-cyclophosphamide-and-autologous-stem-cell-transplantation-for-patients-with-primary-central-nervous-system-lymphoma-in-first-complete-remission
#9
Zachariah DeFilipp, Shuli Li, Areej El-Jawahri, Philippe Armand, Lakshmi Nayak, Nancy Wang, Tracy T Batchelor, Yi-Bin Chen
BACKGROUND: High-dose chemotherapy and autologous stem cell transplantation (HDC-ASCT) is a therapeutic option for patients with primary central nervous system lymphoma (PCNSL). To the authors' knowledge, data are limited regarding its use among patients in first complete remission (CR1) with the CNS-directed conditioning regimen of thiotepa, busulfan, and cyclophosphamide (TBC). METHODS: A retrospective analysis of patients with PCNSL in CR1 who underwent transplantation using a TBC-based conditioning regimen at 2 academic institutions was performed...
April 3, 2017: Cancer
https://www.readbyqxmd.com/read/28292732/alternating-hemiplegia-and-epilepsia-partialis-continua-a-new-phenotype-for-a-novel-compound-tbc1d24-mutation
#10
Francesca Ragona, Barbara Castellotti, Barbara Salis, Stefania Magri, Jacopo C DiFrancesco, Nardo Nardocci, Silvana Franceschetti, Cinzia Gellera, Tiziana Granata
Mutations in the TBC1D24 gene (MIM 613577) cause familial infantile myoclonic epilepsy (FIME; 605021) and early infantile epileptic encephalopathy-16 (EIEE16; 615338), both inherited with an autosomal recessive trait. The TBC1D24 gene encodes a member of the TBC family domain proteins, involved in cell signaling and oxidative stress resistance. We studied, by a Next Generation Sequencing (NGS) target re-sequencing gene approach, the DNA of a 5 year-old girl, affected by recurrent attacks of Alternating Hemiplegia (AH) and by recurrent episodes of Epilepsia Partialis Continua (EPC)...
April 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28274338/development-and-initial-validation-of-primary-care-provider-mental-illness-management-and-team-based-care-self-efficacy-scales
#11
Danielle F Loeb, Lori A Crane, Erin Leister, Elizabeth A Bayliss, Evette Ludman, Ingrid A Binswanger, Danielle M Kline, Meredith Smith, Frank V deGruy, Donald E Nease, L Miriam Dickinson
OBJECTIVE: Develop and validate self-efficacy scales for primary care provider (PCP) mental illness management and team-based care participation. STUDY DESIGN AND SETTING: We developed three self-efficacy scales: team-based care (TBC), mental illness management (MIM), and chronic medical illness (CMI). We developed the scales using Bandura's Social Cognitive Theory as a guide. The survey instrument included items from previously validated scales on team-based care and mental illness management...
March 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28183165/evaluation-of-microbiological-cellular-and-risk-factors-associated-with-subclinical-mastitis-in-female-buffaloes
#12
Emmanuella Oliveira Moura, Adriano Henrique do Nascimento Rangel, Maria Celeste Nunes de Melo, Luiz Henrique Fernandes Borba, Dorgival Morais de Lima Júnior, Luciano Patto Novaes, Stela Antas Urbano, Júlio César de Andrade Neto
Objective: This study aimed to evaluate the microbiological and cellular milk profile for the diagnosis of subclinical mastitis in female buffaloes and to assess risk factors for predisposition of the disease. Methods: Analyses were carried out by standard plate count (SPC), identification of species and antibiotic resistance, somatic cell count (SCC), electrical conductivity of milk (ECM), and Lactoferrin content in milk (Lfe). Teat cups were swabbed to evaluate risk factors, observing hyperkeratosis, milking vacuum pressure and cleanliness of the site...
February 1, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28176461/high-resolution-localization-of-rab5-eea1-and-nectin-3-to-tubulobulbar-complexes-in-the-rat-testis
#13
Arlo Adams, A Wayne Vogl
Tubulobulbar complexes are clathrin/actin-based structures that internalize intercellular junctions in the testis. They resemble coated pits with extremely long necks that are cuffed by dendritic actin networks. As the structures mature, a swollen region or bulb develops near the end of each complex. The bulbs lack actin cuffs and are closely associated with cisternae of endoplasmic reticulum. The bulbs expand and are internalized and enter endocytic compartments of the Sertoli cell. Previous immunofluorescence studies have demonstrated that markers for early endosomes (Rab5 and EEA1) are associated with tubulobulbar complexes and are localized at or near the ends of the structures...
February 8, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28168758/crystal-structure-of-tbc1d15-gtpase-activating-protein-gap-domain-and-its-activity-on-rab-gtpases
#14
Yan-Na Chen, Xin Gu, X Edward Zhou, Weidong Wang, Dandan Cheng, Yinghua Ge, Fei Ye, H Eric Xu, Zhengbing Lv
TBC1D15 belongs to the TBC (Tre-2/Bub2/Cdc16) domain family and functions as a GTPase-activating protein (GAP) for Rab GTPases. So far, the structure of TBC1D15 or the TBC1D15·Rab complex has not been determined, thus, its catalytic mechanism on Rab GTPases is still unclear. In this study, we solved the crystal structures of the Shark and Sus TBC1D15 GAP domains, to 2.8 Å and 2.5 Å resolution, respectively. Shark-TBC1D15 and Sus-TBC1D15 belong to the same subfamily of TBC domain-containing proteins, and their GAP-domain structures are highly similar...
April 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28163124/efficient-separation-of-mannan-protein-mixtures-by-ionic-liquid-aqueous-two-phase-system-comparison-with-lectin-affinity-purification
#15
COMPARATIVE STUDY
Alžbeta Čížová, Jana Korcová, Pavol Farkaš, Slavomír Bystrický
Analysis of carbohydrates from complex biological samples often requires their isolation from proteins and other contaminants to avoid interference. An effective separation of mannan-protein mixtures by 1-butyl-3-methylimidazolium bromide/K2HPO4 ionic liquid aqueous two-phase system (IL-APTS) is reported. Extraction efficiency of bovine serum albumin (BSA) ranged from 92% to 97% while extraction efficiency of mannan reached values from 95% to about 100% depending on phase and/or model sample composition. On the contrary, lower efficiency of BSA removal (73-84%) was recorded for lectin affinity purification with concanavalin A-triazine bead cellulose (Con A-TBC); the low mannan-binding capacity was limiting factor here...
May 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28145072/effect-of-quality-of-colostrum-on-health-growth-and-immunoglobulin-g-concentration-in-holstein-calves-in-a-hot-environment
#16
Miguel Mellado, Edir Torres, Francisco G Veliz, Angeles de Santiago, Ulises Macias-Cruz, Jose E Garcia
The aim of this study was to determine the effect of ingestion of pasteurized and subsequently frozen-thawed pooled colostrum (≥50 mg Ig/mL) with different bacterial counts and immunoglobulin concentration (IgC) on the occurrence of diarrhea and pneumonia in 306 neonatal Holstein calves in a hot environment. Calves were assigned to be fed colostrum with total bacterial counts (TBC) lower or greater than 100 000 colony-forming units (cfu)/mL, total coliform counts (TCC) greater or lower than 10 000 cfu/mL, and IgC lower or higher than 85 mg Ig/mL...
February 1, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28109266/team-based-care-for-improving-hypertension-management-among-outpatients-tbc-hta-study-protocol-for-a-pragmatic-randomized-controlled-trial
#17
Valérie Santschi, Grégoire Wuerzner, Arnaud Chiolero, Bernard Burnand, Philippe Schaller, Lyne Cloutier, Gilles Paradis, Michel Burnier
BACKGROUND: Blood pressure (BP) is poorly controlled among a large proportion of hypertensive outpatients. Innovative models of care are therefore needed to improve BP control. The Team-Based Care for improving Hypertension management (TBC-HTA) study aims to evaluate the effect of a team-based care (TBC) interprofessional intervention, involving nurses, community pharmacists and physicians, on BP control of hypertensive outpatients compared to usual care in routine clinical practice. METHODS/DESIGN: The TBC-HTA study is a pragmatic randomized controlled study with a 6-month follow-up which tests a TBC interprofessionnal intervention conducted among uncontrolled treated hypertensive outpatients in two ambulatory clinics and among seven nearby community pharmacies in Lausanne and Geneva, Switzerland...
January 21, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28088541/secretory-pathway-optimization-of-cho-producer-cells-by-co-engineering-of-the-mitosrna-1978-target-genes-cers2-and-tbc1d20
#18
Lisa A Pieper, Michaela Strotbek, Till Wenger, Martin Gamer, Monilola A Olayioye, Angelika Hausser
Chinese Hamster Ovary (CHO) cells are the most commonly used host for the production of biopharmaceuticals. Although transcription and translation engineering strategies have been employed to generate high-producer cell clones, the secretory pathway still remains a bottleneck in cellular productivity. In this study we show that ectopic expression of a human mitochondrial genome-encoded small RNA (mitosRNA-1978) in an IgG expressing CHO cell line strongly improved specific productivity by functioning in a microRNA-like fashion...
January 11, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/28067790/rab10-interacts-with-the-male-germ-cell-specific-gtpase-activating-protein-during-mammalian-spermiogenesis
#19
Ying-Hung Lin, Chih-Chun Ke, Ya-Yun Wang, Mei-Feng Chen, Tsung-Ming Chen, Wei-Chi Ku, Han-Sun Chiang, Chung-Hsin Yeh
According to recent estimates, 2%-15% of couples are sterile, and approximately half of the infertility cases are attributed to male reproductive factors. However, the reasons remain undefined in approximately 25% of male infertility cases, and most infertility cases exhibit spermatogenic defects. Numerous genes involved in spermatogenesis still remain unknown. We previously identified Male Germ Cells Rab GTPase-Activating Proteins (MGCRABGAPs) through cDNA microarray analysis of human testicular tissues with spermatogenic defects...
January 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28035613/elucidation-of-the-tidal-influence-on-bacterial-populations-in-a-monsoon-influenced-estuary-through-simultaneous-observations
#20
Lidita Khandeparker, Ranjith Eswaran, Laxman Gardade, Nishanth Kuchi, Kaushal Mapari, Sneha D Naik, Arga Chandrashekar Anil
The influence of tides on bacterial populations in a monsoon influenced tropical estuary was assessed through fine resolution sampling (1 to 3 h) during spring and neap tides from mouth to the freshwater end at four stations during pre-monsoon, monsoon and post-monsoon seasons. Higher abundance of total bacterial count (TBC) in surface water near the river mouth, compared to the upstream, during pre-monsoon was followed by an opposite scenario during the monsoon When seasonally compared, it was during the post-monsoon season when TBC in surface water was highest, with simultaneous decrease in their count in the river sediment...
January 2017: Environmental Monitoring and Assessment
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