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https://www.readbyqxmd.com/read/28631644/evaluation-of-a-new-rapid-kit-bd-mgit-tbc-identification-test-for-confirmation-of-mycobacterium-tuberculosis-complex
#1
Gandhi Kandhakumari, Selvaraj Stephen
At present, three rapid kits are available globally for the confirmation of Mycobacterium tuberculosis complex (MTBC) in cultures by MPT64 antigen (MPT64 Ag) detection. These include Capilia TB, SD Bioline, and BD MGIT TBc Identification (TBcID). The third kit is yet to be validated in India. We have tested this kit and compared with SD Bioline using conventional tests as gold standard. Seventy-one MTBC (70 M. tuberculosis and one Mycobacterium bovis) and four nontuberculous mycobacteria (NTM) were isolated from 649 clinical specimens in MGIT 960 and/or Lowenstein-Jensen slants (LJ)...
April 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28602124/composite-scaffolds-of-mineralized-natural-extracellular-matrix-on-true-bone-ceramic-induce-bone-regeneration-via-smad1-5-8-and-erk1-2-pathways
#2
Tingfang Sun, Sheng Yao, Man Liu, Yushi Yang, Yanhui Ji, Wei Cui, Yanzhen Qu, Xiao-Dong Guo
A stem cell-derived mineralized extracellular matrix (ECM) may be a good strategy to endow scaffolds with a bone microenvironment, thus inducing bone regeneration. However, it also faces some challenges, such as limited cell number, additional wound for autologous cell isolation, and time consumption of cell expansion. In this study, we designed a novel tissue-derived ECM scaffold fabricated by depositing porcine small intestinal submucosa (SIS) ECM on true bone ceramic (TBC), which was followed by mineralization treatment (mSIS/TBC)...
June 10, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28589861/evolution-of-translational-bioinformatics-lessons-learned-from-tbc-2016
#3
Kye Hwa Lee, Ju Han Kim
No abstract text is available yet for this article.
May 24, 2017: BMC Medical Genomics
https://www.readbyqxmd.com/read/28575021/chinook-salmon-and-green-sturgeon-migrate-through-san-francisco-estuary-despite-large-distortions-in-the-local-magnetic-field-produced-by-bridges
#4
A Peter Klimley, Megan T Wyman, Robert Kavet
Empirical evidence exists that some marine animals perceive and orient to local distortions in the earth's main static geomagnetic field. The magnetic fields produced by undersea electric power cables that carry electricity from hydrokinetic energy sources to shore-based power stations may produce similar local distortions in the earth's main field. Concerns exist that animals migrating along the continental shelves might orient to the magnetic field from the cables, and move either inshore or offshore away from their normal path...
2017: PloS One
https://www.readbyqxmd.com/read/28552992/microrna-200b-is-downregulated-in-colon-cancer-budding-cells
#5
Kirsten Nguyen Knudsen, Jan Lindebjerg, Boye Schnack Nielsen, Torben Frøstrup Hansen, Flemming Brandt Sørensen
BACKGROUND: The microRNA-200 (miR-200) family acts as a major suppressor of epithelial-mesenchymal transition (EMT). Impaired miR-200 expression may lead to EMT initiation and eventually cancer dissemination. The presence of tumor budding cells (TBC) is associated with metastasis and poor prognosis, and molecular similarities to EMT indicate that these cells may reflect ongoing EMT. The aim of this study was to investigate the expression of miR-200b in budding cells of colon cancer and the relationship with the EMT-markers E-cadherin, β-catenin and laminin-5γ2...
2017: PloS One
https://www.readbyqxmd.com/read/28486663/ca2-signaling-machinery-is-present-at-intercellular-junctions-and-structures-associated-with-junction-turnover-in-rat-sertoli-cells
#6
Kevin Lyon, Arlo Adams, Matthew Piva, Parisa Asghari, Edwin D Moore, A Wayne Vogl
The endoplasmic reticulum (ER) is a prominent organelle in Sertoli cells. It is an integral component of unique adhesion junctions (ectoplasmic specializations-ESs) in this cell type, and is closely associated with structures termed tubulobulbar complexes (TBCs) that internalize intercellular junctions during sperm release and during the translocation of spermatocytes through the blood-testis barrier. A role for the ER in Ca2+ regulation at ESs and TBCs has been suspected, but evidence for this function has proved elusive...
May 8, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28486215/phonon-thermal-transport-in-silicene-germanene-superlattice-a-molecular-dynamics-study
#7
Xinyu Wang, Yang Hong, Paddy K L Chan, Jingchao Zhang
Two-dimensional (2D) hybrid materials have drawn enormous attentions in thermoelectric applications. In this work, we apply molecular dynamics (MD) simulation to investigate the phonon thermal transport in silicene-germanene superlattice. A non-monotonic thermal conductivity of silicene-germanene superlattice with period length is revealed, which is due to the coherent-incoherent phonon conversion and phonon confinement mechanisms. We also calculate the thermal conductivity of Si-Ge random mixing monolayer, showing a U-shaped trend...
May 9, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28469824/traction-test-of-temporary-dental-cements
#8
Juan-Luis Román-Rodríguez, Diego Millan-Martínez, Antonio Fons-Font, Rubén Agustín-Panadero, Lucía Fernández-Estevan
BACKGROUND: Classic self-curing temporary cements obstruct the translucence of provisional restorations. New dual-cure esthetic temporary cements need investigation and comparison with classic cements to ensure that they are equally retentive and provide adequate translucence. The objective is to analyze by means of traction testing in a in vitro study the retention of five temporary cements. MATERIAL AND METHODS: Ten molars were prepared and ten provisional resin restorations were fabricated using CAD-CAM technology (n=10)...
April 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28466854/increase-the-elongation-at-break-of-poly-lactic-acid-composites-for-use-in-food-packaging-films
#9
Ahmed M El-Hadi
Poly (3-hydroxy butyrate) (PHB), cellulose nano crystal (CNC) and a plasticizer (TBC) are mixed together with PLLA with the aim to increase the elongation at break for use in the food packing sector. Spherical (CNC) and fibril nano crystal (CNF) were prepared by hydrolysis of microcrystalline cellulose (MCC) in distilled water, and then stirred using a magnetic stirrer for 15 days and ultrasonic treatment without using any acids as green method. The morphology, thermal, and mechanical properties were studied using POM, DSC, WAXD, SEM and tensile testing, respectively...
May 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28455411/the-vps34-pi3k-negatively-regulates-rab-5-during-endosome-maturation
#10
Fiona Law, Jung Hwa Seo, Ziqing Wang, Jennifer L DeLeon, Yousstina Bolis, Ashley Brown, Wei-Xing Zong, Guangwei Du, Christian E Rocheleau
The GTPase Rab5 and phosphatidylinositol-3 phosphate [PI(3)P] coordinately regulate endosome trafficking. Rab5 recruits Vps34, the class III phosphoinositide 3-kinase (PI3K), to generate PI(3)P and recruit PI(3)P-binding proteins. Loss of Rab5 and loss of Vps34 have opposite effects on endosome size, suggesting that our understanding of how Rab5 and PI(3)P cooperate is incomplete. Here, we report a novel regulatory loop whereby Caenorhabditis elegans VPS-34 inactivates RAB-5 via recruitment of the TBC-2 Rab GTPase-activating protein...
June 15, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28434737/short-communication-microbiological-quality-of-raw-cow-milk-and-its-association-with-herd-management-practices-in-northern-china
#11
X Y Lan, S G Zhao, N Zheng, S L Li, Y D Zhang, H M Liu, J McKillip, J Q Wang
Contamination of raw milk with bacterial pathogens is potentially hazardous to human health. The aim of this study was to evaluate the total bacteria count (TBC) and presence of pathogens in raw milk in Northern China along with the associated herd management practices. A total of 160 raw milk samples were collected from 80 dairy herds in Northern China. All raw milk samples were analyzed for TBC and pathogens by culturing. The results showed that the number of raw milk samples with TBC <2 × 10(6) cfu/mL and <1 × 10(5) cfu/mL was 146 (91...
April 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28388845/energy-dissipation-in-monolayer-mos2-electronics
#12
Eilam Yalon, Connor J McClellan, Kirby K H Smithe, Miguel Muñoz Rojo, Runjie Lily Xu, Saurabh V Suryavanshi, Alex J Gabourie, Christopher M Neumann, Feng Xiong, Amir Barati Farimani, Eric Pop
The advancement of nanoscale electronics has been limited by energy dissipation challenges for over a decade. Such limitations could be particularly severe for two-dimensional (2D) semiconductors integrated with flexible substrates or multilayered processors, both being critical thermal bottlenecks. To shed light into fundamental aspects of this problem, here we report the first direct measurement of spatially resolved temperature in functioning 2D monolayer MoS2 transistors. Using Raman thermometry, we simultaneously obtain temperature maps of the device channel and its substrate...
June 14, 2017: Nano Letters
https://www.readbyqxmd.com/read/28384198/tbc1d12-is-a-novel-rab11-binding-protein-that-modulates-neurite-outgrowth-of-pc12-cells
#13
Mai E Oguchi, Kenta Noguchi, Mitsunori Fukuda
Recycling endosomes are generally thought to play a central role in endocytic recycling, but recent evidence has indicated that they also participate in other cellular events, including cytokinesis, autophagy, and neurite outgrowth. Rab small GTPases are key regulators in membrane trafficking, and although several Rab isoforms, e.g., Rab11, have been shown to regulate recycling endosomal trafficking, the precise mechanism by which these Rabs regulate recycling endosomes is not fully understood. In this study, we focused on a Rab-GTPase-activating protein (Rab-GAP), one of the key regulators of Rabs, and comprehensively screened 43 mammalian Tre-2/Bub2/Cdc16 (TBC)/Rab-GAP-domain-containing proteins (TBC proteins) for proteins that specifically localize on recycling endosomes in mouse embryonic fibroblasts (MEFs)...
2017: PloS One
https://www.readbyqxmd.com/read/28369839/high-dose-chemotherapy-with-thiotepa-busulfan-and-cyclophosphamide-and-autologous-stem-cell-transplantation-for-patients-with-primary-central-nervous-system-lymphoma-in-first-complete-remission
#14
Zachariah DeFilipp, Shuli Li, Areej El-Jawahri, Philippe Armand, Lakshmi Nayak, Nancy Wang, Tracy T Batchelor, Yi-Bin Chen
BACKGROUND: High-dose chemotherapy and autologous stem cell transplantation (HDC-ASCT) is a therapeutic option for patients with primary central nervous system lymphoma (PCNSL). To the authors' knowledge, data are limited regarding its use among patients in first complete remission (CR1) with the CNS-directed conditioning regimen of thiotepa, busulfan, and cyclophosphamide (TBC). METHODS: A retrospective analysis of patients with PCNSL in CR1 who underwent transplantation using a TBC-based conditioning regimen at 2 academic institutions was performed...
April 3, 2017: Cancer
https://www.readbyqxmd.com/read/28292732/alternating-hemiplegia-and-epilepsia-partialis-continua-a-new-phenotype-for-a-novel-compound-tbc1d24-mutation
#15
Francesca Ragona, Barbara Castellotti, Barbara Salis, Stefania Magri, Jacopo C DiFrancesco, Nardo Nardocci, Silvana Franceschetti, Cinzia Gellera, Tiziana Granata
Mutations in the TBC1D24 gene (MIM 613577) cause familial infantile myoclonic epilepsy (FIME; 605021) and early infantile epileptic encephalopathy-16 (EIEE16; 615338), both inherited with an autosomal recessive trait. The TBC1D24 gene encodes a member of the TBC family domain proteins, involved in cell signaling and oxidative stress resistance. We studied, by a Next Generation Sequencing (NGS) target re-sequencing gene approach, the DNA of a 5 year-old girl, affected by recurrent attacks of Alternating Hemiplegia (AH) and by recurrent episodes of Epilepsia Partialis Continua (EPC)...
April 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28274338/development-and-initial-validation-of-primary-care-provider-mental-illness-management-and-team-based-care-self-efficacy-scales
#16
Danielle F Loeb, Lori A Crane, Erin Leister, Elizabeth A Bayliss, Evette Ludman, Ingrid A Binswanger, Danielle M Kline, Meredith Smith, Frank V deGruy, Donald E Nease, L Miriam Dickinson
OBJECTIVE: Develop and validate self-efficacy scales for primary care provider (PCP) mental illness management and team-based care participation. STUDY DESIGN AND SETTING: We developed three self-efficacy scales: team-based care (TBC), mental illness management (MIM), and chronic medical illness (CMI). We developed the scales using Bandura's Social Cognitive Theory as a guide. The survey instrument included items from previously validated scales on team-based care and mental illness management...
March 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28183165/evaluation-of-microbiological-cellular-and-risk-factors-associated-with-subclinical-mastitis-in-female-buffaloes
#17
Emmanuella Oliveira Moura, Adriano Henrique do Nascimento Rangel, Maria Celeste Nunes de Melo, Luiz Henrique Fernandes Borba, Dorgival Morais de Lima Júnior, Luciano Patto Novaes, Stela Antas Urbano, Júlio César de Andrade Neto
Objective: This study aimed to evaluate the microbiological and cellular milk profile for the diagnosis of subclinical mastitis in female buffaloes and to assess risk factors for predisposition of the disease. Methods: Analyses were carried out by standard plate count (SPC), identification of species and antibiotic resistance, somatic cell count (SCC), electrical conductivity of milk (ECM), and Lactoferrin content in milk (Lfe). Teat cups were swabbed to evaluate risk factors, observing hyperkeratosis, milking vacuum pressure and cleanliness of the site...
February 1, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28176461/high-resolution-localization-of-rab5-eea1-and-nectin-3-to-tubulobulbar-complexes-in-the-rat-testis
#18
Arlo Adams, A Wayne Vogl
Tubulobulbar complexes are clathrin/actin-based structures that internalize intercellular junctions in the testis. They resemble coated pits with extremely long necks that are cuffed by dendritic actin networks. As the structures mature, a swollen region or bulb develops near the end of each complex. The bulbs lack actin cuffs and are closely associated with cisternae of endoplasmic reticulum. The bulbs expand and are internalized and enter endocytic compartments of the Sertoli cell. Previous immunofluorescence studies have demonstrated that markers for early endosomes (Rab5 and EEA1) are associated with tubulobulbar complexes and are localized at or near the ends of the structures...
February 8, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28168758/crystal-structure-of-tbc1d15-gtpase-activating-protein-gap-domain-and-its-activity-on-rab-gtpases
#19
Yan-Na Chen, Xin Gu, X Edward Zhou, Weidong Wang, Dandan Cheng, Yinghua Ge, Fei Ye, H Eric Xu, Zhengbing Lv
TBC1D15 belongs to the TBC (Tre-2/Bub2/Cdc16) domain family and functions as a GTPase-activating protein (GAP) for Rab GTPases. So far, the structure of TBC1D15 or the TBC1D15·Rab complex has not been determined, thus, its catalytic mechanism on Rab GTPases is still unclear. In this study, we solved the crystal structures of the Shark and Sus TBC1D15 GAP domains, to 2.8 Å and 2.5 Å resolution, respectively. Shark-TBC1D15 and Sus-TBC1D15 belong to the same subfamily of TBC domain-containing proteins, and their GAP-domain structures are highly similar...
April 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28163124/efficient-separation-of-mannan-protein-mixtures-by-ionic-liquid-aqueous-two-phase-system-comparison-with-lectin-affinity-purification
#20
COMPARATIVE STUDY
Alžbeta Čížová, Jana Korcová, Pavol Farkaš, Slavomír Bystrický
Analysis of carbohydrates from complex biological samples often requires their isolation from proteins and other contaminants to avoid interference. An effective separation of mannan-protein mixtures by 1-butyl-3-methylimidazolium bromide/K2HPO4 ionic liquid aqueous two-phase system (IL-APTS) is reported. Extraction efficiency of bovine serum albumin (BSA) ranged from 92% to 97% while extraction efficiency of mannan reached values from 95% to about 100% depending on phase and/or model sample composition. On the contrary, lower efficiency of BSA removal (73-84%) was recorded for lectin affinity purification with concanavalin A-triazine bead cellulose (Con A-TBC); the low mannan-binding capacity was limiting factor here...
May 2017: International Journal of Biological Macromolecules
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