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Ásthildur Árnadóttir, Mikkel Schoos, Jacob Lønborg, Kiril Ahtarovski, Henning Kelbæk, Steffen Helqvist, Dan Høfsten, Peter Clemmensen, Thomas Engstrøm, Lars Nepper-Christensen, Niels Vejlstrup, Lars Køber, Kasper Iversen
BACKGROUND: Primary percutaneous coronary intervention (pPCI) is recommended in patients presenting with ST-elevation myocardial infarction (STEMI) within <12 h of symptom onset. However, patients-reported symptom duration is not always reliable. Cardiac specific troponin T (cTnT) and the endogenous stress marker copeptin have different temporal release patterns for myocardial infarction MI. We hypothesized that copeptin/troponin-ratio is associated to the duration of coronary occlusion and therefore inversely proportional to myocardial salvage...
June 19, 2018: Clinical Biochemistry
Reidun Aarsetøy, Hildegunn Aarsetøy, Tor-Arne Hagve, Heidi Strand, Harry Staines, Dennis W T Nilsen
Aim: Sudden cardiac arrest (SCA) secondary to ventricular fibrillation (VF) may be due to different cardiac conditions. We investigated whether copeptin, hs-cTnT and NT-proBNP in addition to clinical assessment may help to identify the etiology of SCA and yield prognostic information. Methods and Results: EDTA-blood was collected prior to or at hospital admission from patients with SCA of assumed cardiac origin. Clinical data were obtained from hospital records...
2018: Frontiers in Cardiovascular Medicine
S D Braun, M Kuhn, S Bergmann, S Katzke, M Weise, N Alakel, F Stölzel, F Kroschinsky, G Ehninger, G Höffken, M Bornhäuser
To predict the need of intensive care unit admission with organ support during the transplantation hospital stay in 101 consecutives allogeneic hematopoietic cell transplantation (allo-HCT) recipients the added predictive utility of three times per week Copeptin, MR-proADM, MR-proANP, NT-proBNP, IL-6, Procalcitonin, D-dimer and three times per week bed-sided pulmonary function test was determined in comparison with an index model. The index model was calculated by multivariate regression analysis out of the patients' routine laboratory parameters...
June 21, 2018: Bone Marrow Transplantation
Ray El Boustany
BACKGROUND: Diabetic nephropathy has become the most common cause of chronic kidney disease (CKD). Despite the progress accomplished in therapy, the prevalence of renal disorders remains high. Some modifiable factors driving the increase in incidence of CKD, in diabetes and other settings, might have been overlooked. Consistent evidence supports a role for vasopressin, hydration state, and urine concentration in kidney health. SUMMARY: Plasma vasopressin is elevated in diabetes, even if metabolic control is good...
2018: Annals of Nutrition & Metabolism
Sofia Enhörning, Olle Melander
BACKGROUND: Type 2 diabetes, chronic kidney disease (CKD) and its cardiovascular complications are increasing as health problems worldwide. These diseases are interrelated with overlapping occurrence and once diabetes is established, the risk of cardiorenal disease is dramatically elevated. Thus, a search for unifying modifiable risk factors is key for effective prevention. SUMMARY: Elevated fasting plasma concentration of vasopressin, measured with the marker copeptin, predicts new onset type 2 diabetes as well as renal function decline...
2018: Annals of Nutrition & Metabolism
Jeffrey Netto, Boris Jansen-Winkeln, René Thieme, Jan Eckardt, Yoon Ju Bae, Anja Willenberg, Sabine Huppert, Orestes Lyros, Stefan Niebisch, Friederike Allecke, Nicole Kreuser, Jürgen Kratzsch, Thorsten Kaiser, Uta Ceglarek, Joachim Thiery, Ines Gockel
INTRODUCTION: Any surgical procedure develops a stress situation for the patient, which can modulate the individual outcome. At present, there is only limited information about stress response in colorectal resections by laparoscopic compared to conventional surgery. Therefore, our objectives were the feasibility and the investigation of stress biomarkers including copeptin and steroid hormones before, during and after colorectal surgery. METHODS: Eleven patients underwent minimally invasive and ten patients conventionally open colorectal surgery...
June 17, 2018: Acta Chirurgica Belgica
William F Clark, Jessica M Sontrop, Shih-Han Huang, Kerri Gallo, Louise Moist, Andrew A House, Meaghan S Cuerden, Matthew A Weir, Amit Bagga, Scott Brimble, Andrew Burke, Norman Muirhead, Sanjay Pandeya, Amit X Garg
Importance: In observational studies, increased water intake is associated with better kidney function. Objective: To determine the effect of coaching to increase water intake on kidney function in adults with chronic kidney disease. Design, Setting, and Participants: The CKD WIT (Chronic Kidney Disease Water Intake Trial) randomized clinical trial was conducted in 9 centers in Ontario, Canada, from 2013 until 2017 (last day of follow-up, May 25, 2017)...
May 8, 2018: JAMA: the Journal of the American Medical Association
Kyeongman Jeon, Jae-Uk Song, Chi Ryang Chung, Jeong Hoon Yang, Gee Young Suh
BACKGROUND: Vasopressin (AVP) is commonly added to norepinephrine (NE) to reverse shock in patients with sepsis. However, there are no data to support the appropriate strategy of vasopressor tapering in patients on concomitant NE and AVP who are recovering from septic shock. Therefore, the objective of this study was to evaluate the incidence of hypotension while tapering vasopressors in patients on concomitant NE and AVP recovering from septic shock. METHODS: Patients with septic shock receiving concomitant NE and AVP were randomly assigned to taper NE first (NE group) or AVP first (AVP group)...
May 21, 2018: Critical Care: the Official Journal of the Critical Care Forum
Piotr Skrzypczyk, Magdalena Okarska-Napierała, Elżbieta Górska, Anna Stelmaszczyk-Emmel, Małgorzata Pańczyk-Tomaszewska
Studies in adult patients suggest that copeptin (C-terminal fragment of antidiuretin propeptide) is related to kidney and cardiovascular diseases. AIM: The aim was to assess copeptin concentration in children with chronic kidney disease (CKD). MATERIALS AND METHODS: In a group of 38 children with CKD (age: from 4.70 to 18.00 mean 12.23±4.19 years) we evaluated: serum copeptin concentration [ng/mL], age, sex, etiology of CKD, presence of arterial hypertension (AH), medications, glomerular filtration rate (GFR), hemoglobin, calcium-phosphorus metabolism parameters, and lipids...
April 23, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Firmin Kamber, Eckhard Mauermann, Esther Seeberger, Lorenz Guerke, Christian Mueller, Daniel Bolliger, Giovanna A L Lurati Buse
BACKGROUND: Copeptin levels in conjunction with cardiac troponin may be used to rule out early myocardial infarction in patients presenting with chest pain. Raised pre-operative copeptin has been shown to be associated with postoperative cardiac events. However, very little is known about the peri-operative time course of copeptin or the feasibility of very early postoperative copeptin measurement to diagnose or rule-out myocardial injury. OBJECTIVES: In this preparatory analysis for a larger trial, we sought to examine the time course of peri-operative copeptin and identify the time at which concentrations returned to pre-operative levels...
May 9, 2018: European Journal of Anaesthesiology
Neil Beri, Lori B Daniels, Allan Jaffe, Christian Mueller, Inder Anand, W Frank Peacock, Judd E Hollander, Christopher DeFilippi, Donald Schreiber, James McCord, Alexander T Limkakeng, Alan H B Wu, Fred S Apple, Deborah B Diercks, John T Nagurney, Richard M Nowak, Chad M Cannon, Paul Clopton, Sean-Xavier Neath, Robert H Christenson, Christopher Hogan, Gary Vilke, Alan Maisel
BACKGROUND: Copeptin in combination with troponin has been shown to have incremental value for the early rule-out of myocardial infarction, but its performance in Black patients specifically has never been examined. In light of a potential for wider use, data on copeptin in different relevant cohorts are needed. This is the first study to determine whether copeptin is equally effective at ruling out myocardial infarction in Black and Caucasian races. METHODS: This analysis of the CHOPIN trial included 792 Black and 1075 Caucasian patients who presented to the emergency department with chest pain and had troponin-I and copeptin levels drawn...
May 1, 2018: European Heart Journal. Acute Cardiovascular Care
Sandra J Fernandez, Ibraham Barakat, James Ziogas, Tony Frugier, Stanley S Stylli, John D Laidlaw, Andrew H Kaye, Alexios A Adamides
OBJECTIVE Delayed ischemic neurological deficit (DIND) is a leading cause of mortality and morbidity after aneurysmal subarachnoid hemorrhage (aSAH). Arginine vasopressin (AVP) is a hormone released by the posterior pituitary. It is known to cause cerebral vasoconstriction and has been implicated in hyponatremia secondary to the syndrome of inappropriate antidiuretic hormone secretion. Direct measurement of AVP is limited by its short half-life. Copeptin, a cleavage product of the AVP precursor protein, was therefore used as a surrogate marker for AVP...
May 4, 2018: Journal of Neurosurgery
Z Huang, J Zhong, Y Ling, Y Zhang, W Lin, L Tang, J Liu, S Li
BACKGROUND: The present meta-analysis examined the diagnostic value of novel biomarkers for heart failure (HF), including copeptin, galectin-3, hs-cTnT, MR-proANP, MR-proADM, and ST2. METHODS: English (EMBASE, Cochrane, and PubMed) and Chinese (Wanfang data, CNKI, SinoMed) databases were searched to identify suitable studies that were published before 1 December 2016. Data were extracted using standard forms. Pooled diagnostic statistics were calculated using DerSimonian-Laird random-effects models...
April 26, 2018: Herz
Zhili Han, Jiangnan Shu, Qiaoshi Jiang, Hua Cui
In this work, the eletrochemiluminescence (ECL) behavior of Cu2+ /cysteine complexes and N-(aminobutyl)- N-(ethylisoluminol) (ABEI) functionalized gold nanoparticles combined with chitosan (Cu2+ -Cys-ABEI-GNPs-CS) were studied by cyclic voltammetry and a double-step potential, which exhibited excellent ECL properties without any coreactant. It was found that the ECL intensity of Cu2+ -Cys-ABEI-GNPs-CS could increase at least 1 order of magnitude compared with that of Cu2+ -Cys-ABEI-GNPs. Furthermore, a coreactant-free and label-free ECL immunosensor has been established for the determination of early acute myocardial infarction biomarker copeptin based on luminescent immuno-gold nanoassemblys consisting of Cu2+ -Cys-ABEI-GNPs-CS and immuno-gold nanoparticles prepared by connecting copeptin antibody with trisodium citrate stabilized gold nanoparticles...
May 15, 2018: Analytical Chemistry
Maria De La Luz Villela-Torres, Ana Edith Higareda-Mendoza, Anel Gómez-García, Alfonso Rafael Alvarez-Paredes, Elvia García-López, Peter Stenvikel, Harvest F Gu, Abbul Rashid-Qureshi, Bengt Lindholm, Cleto Alvarez-Aguilar
BACKGROUND: Chronic kidney disease (CKD) is a leading complication of type 2 diabetes mellitus (T2DM) and is considered as a public health problem. Copeptin is a surrogate marker of arginine vasopressin (AVP) system and is proposed as a biomarker of decline renal function. OBJECTIVE: Evaluate whether plasma copeptin levels may be used as a biomarker of decline renal function in patients with T2DM. RESEARCH DESIGN AND METHODS: A total of 480 patients with T2DM and different stages of CKD were included...
April 14, 2018: Archives of Medical Research
A Eckart, P Hausfater, D Amin, A Amin, S Haubitz, M Bernard, A Baumgartner, T Struja, A Kutz, M Christ-Crain, A Huber, B Mueller, P Schuetz
BACKGROUND: Hyponatremia is a common feature of acute illness and associated with increased mortality. This may be explained by a stress-mediated activation of the vasopressin system with an increase in free-water reabsorption. OBJECTIVES: To investigate whether the association between hyponatremia and mortality could be explained by activation of the vasopressin system. METHODS: We prospectively enrolled adult, medical patients seeking emergency care in three centres in Switzerland, France and the United States...
April 17, 2018: Journal of Internal Medicine
Luigi M Castello, Livia Salmi, Isabella Zanotti, Clara A Gardino, Marco Baldrighi, Fabio Settanni, Gian C Avanzi
AIM: To investigate the copeptin prognostic role in mild head trauma. METHODS: We enrolled 105 adult patients who entered the emergency room because of recent mild head trauma; we evaluated: clinical picture, imaging and laboratory data (including copeptin). RESULTS: Copeptin resulted higher in mild head trauma patients compared with controls: 29.89 pmol/l versus 7.05 pmol/l; (p = 0.0008). Copeptin failed in identifying patients with or without brain lesions detected by CT scan, and patients with or without adverse events during the 30 days follow-up...
April 5, 2018: Biomarkers in Medicine
Beata Morawiec, Damian Kawecki, Brygida Przywara-Chowaniec, Mariusz Opara, Piotr Muzyk, Lam Ho, Lui Chun Tat, Artur Gabrysiak, Olivier Muller, Ewa Nowalany-Kozielska
Background: In patients admitted with chest pain and suspected acute coronary syndrome (ACS), it is crucial to early identify those who are at higher risk of adverse events. The study aim was to assess the predictive value of copeptin in patients admitted to the emergency department with chest pain and nonconclusive ECG. Methods: Consecutive patients suspected for an ACS were enrolled prospectively. Copeptin and high-sensitive troponin T (hs-TnT) were measured at admission...
2018: Disease Markers
Kristian Hellenkamp, Piotr Pruszczyk, David Jiménez, Anna Wyzgał, Deisy Barrios, Michał Ciurzyński, Raquel Morillo, Lukas Hobohm, Karsten Keller, Katarzyna Kurnicka, Maciej Kostrubiec, Rolf Wachter, Gerd Hasenfuß, Stavros Konstantinides, Mareike Lankeit
To externally validate the prognostic impact of copeptin, either alone or integrated in risk stratification models, in pulmonary embolism (PE), we performed a post hoc analysis of 843 normotensive PE patients prospectively included in three European cohorts.Within the first 30 days, 21 patients (2.5%, 95% CI 1.5-3.8) had an adverse outcome and 12 (1.4%, 95% CI 0.7-2.5) died due to PE. Patients with copeptin ≥24 pmol·L-1 had a 6.3-fold increased risk for an adverse outcome (95% CI 2.6-15.5, p<0.001) and a 7...
April 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Stanisław Niemczyk, Longin Niemczyk, Wawrzyniec Żmudzki, Marek Saracyn, Katarzyna Czarzasta, Katarzyna Szamotulska, Agnieszka Cudnoch-Jędrzejewska
Plasma content of copeptin increases with the advancement of chronic kidney disease (CKD). The purpose of this study was to evaluate copeptin content as a potential marker of CKD, as a single pathology or with coexisting heart failure. Seventy-six patients were divided into the following groups: Group 1 (control), without CKD and heart failure; Group 2, CKD stage 3a; Group 3, CKD stage 3b; Group 4, CKD stage 4; Group 5, CKD stage 5; and Group 6, CKD stage 3b and heart failure. For all patients, plasma concentrations of copeptin, creatinine, urea, cystatin C, sodium, C-reactive protein (CRP), N-terminal prohormone of brain natriuretic peptide (NT-proBNP), and blood pH were assessed...
March 24, 2018: Advances in Experimental Medicine and Biology
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