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https://www.readbyqxmd.com/read/28503166/inhibition-of-ectopic-arginine-vasopressin-production-by-phenytoin-in-the-small-cell-lung-cancer-cell-line-lu-165
#1
Takahiro Ohta, Mitsuo Mita, Shigeru Hishinuma, Reiko Ishii-Nozawa, Kazuhisa Takahashi, Masaru Shoji
Phenytoin, a voltage-gated sodium channel (NaV channel) antagonist, reportedly inhibits arginine vasopressin (AVP) release from an isolated rat neurohypophysis. So far, it is uncertain whether phenytoin has a direct action on ectopic AVP-producing neuroendocrine tumors. We studied the effect of phenytoin on the release of copeptin, the C-terminal fragment of pro-AVP, and expression of AVP gene in the human small cell lung cancer cell line Lu-165. Cells were maintained in RPMI1640 medium with 10% fetal bovine serum and were used within the fifth passage...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28491088/novel-biomarkers-for-cardiovascular-risk-prediction
#2
REVIEW
Juan Wang, Guo-Juan Tan, Li-Na Han, Yong-Yi Bai, Miao He, Hong-Bin Liu
Cardiovascular disease (CVD) is the leading cause of death and disability worldwide. The primary prevention of CVD is dependent upon the ability to identify high-risk individuals long before the development of overt events. This highlights the need for accurate risk stratification. An increasing number of novel biomarkers have been identified to predict cardiovascular events. Biomarkers play a critical role in the definition, prognostication, and decision-making regarding the management of cardiovascular events...
February 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/28486916/are-markers-of-cardiac-dysfunction-useful-in-the-assessment-of-cardiovascular-risk-in-dialysis-patients
#3
Beata Franczyk, Anna Gluba-Brzózka, Piotr Bartnicki, Maciej Banach, Jacek Rysz
Cardiovascular morbidity and mortality of dialysis patients is a major problem in this group. The purpose of this study was also to evaluate whether any of studied markers are better than troponin in early detection of the occurrence of ventricular arrhythmias and prolongation of QT interval. This study included 45 patients undergoing haemodialysis. ECG Holter and echocardiographic examination were performed before and after dialysis. The concentration of markers: copeptin, GDF-15, HFABP and troponin were measured with the use of ELISA tests...
May 8, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28457803/evaluation-of-urinary-aquaporin-2-and-plasma-copeptin-as-biomarkers-of-effectiveness-of-desmopressin-acetate-for-the-treatment-of-monosymptomatic-nocturnal-enuresis
#4
Taichi Hara, Yoshiyuki Ohtomo, Amane Endo, Shinichi Niijima, Masato Yasui, Toshiaki Shimizu
PURPOSE: Desmopressin is a synthetic V2-specific analog of antidiuretic hormone (arginine vasopressin), widely used as a first-line treatment for monosymptomatic nocturnal enuresis. However, no biomarkers to predict desmopressin effectiveness have yet been established. Because arginine vasopressin is unstable, we prospectively measured the major urine concentration factors aquaporin-2 and copeptin (as a surrogate marker for vasopressin) in patients with monosymptomatic nocturnal enuresis, and evaluated whether they are useful for predicting desmopressin treatment outcome...
April 27, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28457001/plasma-copeptin-and-metabolic-dysfunction-in-individuals-with-bipolar-disorder
#5
Rodrigo B Mansur, Lucas B Rizzo, Camila M Santos, Elson Asevedo, Graccielle R Cunha, Mariane N Noto, Mariana Pedrini, Maiara Zeni-Graiff, Quirino Cordeiro, Roger S McIntyre, Elisa Brietzke
AIM: This study aimed to compare plasma copeptin levels, the c-terminal of provasopressin, between individuals with bipolar disorder (BD) and healthy controls and to assess the relationship between copeptin and metabolic parameters. METHODS: We measured plasma levels of copeptin in individuals with BD (N = 55) and healthy controls (N = 21). Information related to psychiatric/medical history, as well as to metabolic comorbidities and laboratorial parameters was also captured...
April 29, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28447918/no-relation-between-biomarkers-at-age-47-49-and-aortic-diameter-after-14-19-years-of-follow-up-a-population-based-study
#6
Soumia Taimour, Moncef Zarrouk, Jan Holst, Olle Melander, Gunar Engström, J Gustav Smith, Anders Gottsäter
BACKGROUND: Biomarkers reflecting diverse pathophysiological pathways may play an important role in the pathogenesis of abdominal aortic aneurysm (aortic diameter ≥30 mm, AAA), levels of many biomarkers are elevated and correlated to aortic diameter among 65-year-old men undergoing ultrasound (US) screening for AAA. PROBANDS AND METHODS: To evaluate potential relationships between biomarkers and aortic dilatation after long-term follow-up, levels of C-reactive protein (CRP), proneurotensin (PNT), copeptin (CPT), lipoprotein-associated phospholipase 2 (Lp-PLA2), cystatin C (Cyst C), midregional proatrial natriuretic peptide (MR-proANP), and midregional proadrenomedullin (MR-proADM) were measured in 117 subjects (114 [97 %] men) aged 47-49 in a prospective population-based cohort study, and related to aortic diameter at US examination of the aorta after 14-19 years of follow-up...
April 27, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28432473/vasopressin-and-vasopressin-antagonists-in-heart-failure
#7
Julie K Vishram-Nielsen, Finn Gustafsson
Despite the introduction of multiple new pharmacological agents over the past three decades in the field of heart failure (HF), overall prognosis remains poor. Hyponatremia is prevalent in HF patients and has been suggested as a contributor to poor response to standard therapy. Elevated levels of arginine vasopressin (AVP), a peptide hormone produced in the hypothalamus, play a role in development of hyponatremia, and AVP and its surrogate, copeptin, are related to changes in osmolality, hemodynamics, neuro-hormones as well as in overall outcome in HF patients...
April 22, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28431872/plasma-copeptin-levels-in-the-patients-with-gastrointestinal-bleeding
#8
Ömer Salt, Polat Durukan, S Ozkan, R Saraymen, A Sen, M A Yurci
INTRODUCTION: Gastrointestinal bleeding is a significant cause of morbidity and mortality worldwide. In addition, it constitutes an important part of health expenditures. In this study, we aimed to determine whether there is a relationship between plasma copeptin levels and the etiology, location and severity of gastrointestinal bleeding. MATERIALS AND METHODS: This study was performed prospectively in 104 consecutive patients who were admitted to an emergency department with complaints of bloody vomiting or bloody or black stool...
April 14, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28429348/diagnostic-value-of-copeptin-in-acute-myocardial-infarction
#9
M O Ay, A K Erenler, T Dogan, M Yetim
OBJECTIVE: The aim of this study was to investigate the effectiveness of copeptin in the early diagnosis of acute myocardial infarction (AMI), and to compare the diagnostic efficacy of copeptin with other cardiac markers. PATIENTS AND METHODS: A total of 160 cases were enrolled in the study. All were over 18 years of age, and consisted of 54 non-ST elevation MI (NSTEMI), 54 ST segment elevation MI (STEMI), and 52 healthy subjects (controls). Serum troponin-I, CK-MB mass, copeptin and CRP levels were measured in each of the cases, and were compared between the three groups for statistical differences...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28425262/copeptin-levels-in-carbon-monoxide-poisoning
#10
Güler Irem, Yunsur Çevik, Ahmet Turgut Keskin, Emine Emektar, Osman Lütfi Demirci, Tuba Şafak, Gülşah Çikrikçi Işik, Kadir Okhan Akin
BACKGROUND/AIM: The aim of this study is to identify the copeptin levels in patients presenting with carbon monoxide (CO) poisoning to the emergency department and to investigate its correlation with the neurological effects. MATERIALS AND METHODS: The study group consisted of patients presenting with CO poisoning and carboxyhemoglobin levels >10%. Blood samples for copeptin levels were obtained twice, first at presentation then at the fourth hour of observation...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28424274/copeptin-and-nt-probnp-for-prediction-of-all-cause-and-cardiovascular-death-in-ischemic-stroke
#11
Wen-Jun Tu, Guo-Zhao Ma, Ying Ni, Xia-Sheng Hu, Ding-Zhen Luo, Xian-Wei Zeng, Qiang Liu, Tingting Xu, Lie Yu, Boshui Wu
OBJECTIVE: To evaluate long-term mortality in patients with acute ischemic stroke (AIS) by exploring the correlation between death and plasma concentrations of copeptin and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in a cohort study. METHODS: In a prospective, multicenter observational study of 4,215 patients with AIS, copeptin and NT-proBNP levels were measured with a standardized method when patients were admitted to hospital. The primary endpoint was all-cause mortality or cardiovascular disease (CVD) mortality within 1 year...
April 19, 2017: Neurology
https://www.readbyqxmd.com/read/28414691/mr-proadm-elevation-upon-icu-admission-predicts-the-outcome-of-septic-patients-and-is-correlated-with-upcoming-fluid-overload
#12
Pierre-Emmanuel Charles, Edwige Péju, Allyriane Dantec, Rémi Bruyère, Nicolas Meunier-Beillard, Auguste Dargent, Sébastien Prin, Darius Wilson, Jean-Pierre Quenot
BACKGROUND: Among septic patients admitted to the intensive care unit (ICU), early recognition of those with the highest risk of death is of paramount importance. We evaluated the prognostic value of Procalcitonin (PCT), mid regional-proadrenomedullin (MR-proADM), copeptine and CT-proendothelin 1 (CT-ProET 1) concentrations. METHODS: This was a prospective cohort study, which included 173 septic patient admitted to one ICU. Blood samples for biomarker measurements were obtained upon admission and on day 5...
April 26, 2017: Shock
https://www.readbyqxmd.com/read/28413508/comparative-evaluation-of-copeptin-and-nt-probnp-in-patients-with-severe-acute-decompensated-heart-failure-and-prediction-of-adverse-events-in-a-90-day-follow-up-period-a-prospective-clinical-observation-trial
#13
Jun Jia, Guang-Lei Chang, Shu Qin, Jia Chen, Wen-Yan He, Kai Lu, Yong Li, Dong-Ying Zhang
The present study compared the prognostic value of a marker, the C-terminal section of the arginine vasopressin prohormone (copeptin), with N-terminal B-type natriuretic peptide (NT-proBNP) in patients with severe acute decompensated heart failure. A prospective, observational cohort study was conducted in a tertiary care hospital and enrolled 129 patients with severe acute decompensated heart failure. Clinicians were blinded to investigational markers except NT-proBNP, and the study participants were followed up for 90 days...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28408815/mid-regional-pro-adrenomedullin-and-copeptin-to-predict-short-term-prognosis-of-copd-exacerbations-a-multicenter-prospective-blinded-study
#14
Martin Dres, Pierre Hausfater, Frantz Foissac, Maguy Bernard, Luc-Marie Joly, Mustapha Sebbane, Anne-Laure Philippon, Cédric Gil-Jardiné, Jeannot Schmidt, Maxime Maignan, Jean-Marc Treluyer, Nicolas Roche
BACKGROUND: Exacerbations of COPD (ECOPD) are a frequent cause of emergency room (ER) visits. Predictors of early outcome could help clinicians in orientation decisions. In the current study, we investigated whether mid-regional pro-adrenomedullin (MR-proADM) and copeptin, in addition to clinical evaluation, could predict short-term outcomes. PATIENTS AND METHODS: This prospective blinded observational study was conducted in 20 French centers. Patients admitted to the ER for an ECOPD were considered for inclusion...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28403013/vasopressin-and-diabetic-nephropathy
#15
Ronan Roussel, Gilberto Velho, Lise Bankir
PURPOSE OF REVIEW: The prevalence of diabetic kidney disease (DKD) is increasing worldwide. Despite major therapeutic advances in the last decades in DKD, the current standard of care let many people progress to severe stages. Vasopressin secretion is increased in diabetes, and its potential role in the onset and progression of DKD is being re-investigated. RECENT FINDINGS: Recently, observational studies evidenced an association between surrogates of vasopressin secretion (daily fluid intake or urine volume, and plasma copeptin concentration) and chronic kidney disease in the community, but also specifically in type 1 and in type 2 diabetes...
April 11, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/28381454/erythropoiesis-with-endurance-training-dynamics-and-mechanisms
#16
David Montero, Andreas Breenfeldt-Andersen, Laura Oberholzer, Thomas Haider, Jens Peter Goetze, Anne-Kristine Meinild-Lundby, Carsten Lundby
The purpose of the present study was to characterize the progression of red blood cell volume (RBCV) expansion and potential volumetric and endocrine regulators of erythropoiesis during endurance training (ET). Nine healthy untrained volunteers (age=27±4 years) underwent supervised ET consisting of 3-4 × 60 min cycle ergometry sessions per week for 8 weeks. Plasma volume (PV), RBCV and overnight fasting hematological markers were determined prior to and at weeks 2, 4 and 8 of ET. In addition, plasma erythropoietin (EPO), cortisol, copeptin and pro-atrial natriuretic peptide concentrations were measured during a 3-hour morning period at baseline and post-exercise at weeks 1 and 8...
April 5, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28351056/comparison-of-umbilical-serum-copeptin-relative-to-erythropoietin-and-s100b-as-asphyxia-biomarkers-at-birth
#17
Milla Summanen, Laura Seikku, Petri Rahkonen, Vedran Stefanovic, Kari Teramo, Sture Andersson, Kai Kaila, Leena Rahkonen
BACKGROUND: Birth asphyxia, estimated to account for a million neonatal deaths annually, can cause a wide variety of neurodevelopmental impairments. There is a need to develop new, swift methods to identify those neonates who would benefit from neuroprotective treatments such as hypothermia. OBJECTIVES: To examine the utility of cord serum copeptin, a stable byproduct of arginine vasopressin release, as a biomarker of birth asphyxia based on a comparison with 2 biomarkers of hypoxia and brain trauma: erythropoietin and S100B...
March 29, 2017: Neonatology
https://www.readbyqxmd.com/read/28321399/renocardiovascular-biomarkers-from-the-perspective-of-managing-chronic-kidney-disease-and-cardiovascular-disease
#18
REVIEW
Shinichiro Niizuma, Yoshitaka Iwanaga, Takaharu Yahata, Shunichi Miyazaki
Mortality among the patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) remains high because of the very high incidence of cardiovascular disease (CVD) such as coronary artery disease, cardiac hypertrophy, and heart failure. Identifying CVD in patients with CKD/ESRD remains a significant hurdle and the early diagnosis and therapy for CVD is crucial in these patients. Therefore, it is necessary for the better management to identify and utilize cardiovascular (CV) biomarkers in profiling CVD risk and enabling stratification of early mortality...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28319005/prediction-of-treatment-response-in-patients-with-newly-diagnosed-type-2-diabetes-the-skaraborg-diabetes-register
#19
Miriam Pikkemaat, Olle Melander, Per Hjerpe, Kristina Bengtsson Boström
AIMS: Type 2 diabetes is associated with cardiovascular complications. It is largely unknown which patients have poor treatment response and high complication risk; biomarkers are studied for this purpose. The aim of the study was to investigate the association between clinical factors such as HbA1c, level of biomarkers (C-peptide, copeptin) at diagnosis and changes in HbA1c, blood pressure or body mass index (BMI) after five years. METHODS: Clinical data and blood samples from 460 newly diagnosed type 2 diabetes patients from the Skaraborg diabetes register (SDR) at diagnosis and after 5years and were analyzed with linear and logistic regressions...
May 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28303751/vasoactive-peptides-associate-with-treatment-outcome-ofbevacizumab-containing-therapy-in-metastatic-colorectal-cancer
#20
Helga Hagman, Pär-Ola Bendahl, Olle Melander, Jan Sundberg, Anders Johnsson, Mattias Belting
BACKGROUND: Hypertension is a common early adverse event of anti-angiogenic treatment of cancer and may associate with treatment response. However, blood pressure measurement as a surrogate response biomarker has methodological limitations, and predictive biomarkers of angiogenesis inhibitors are lacking. In disease associated with hypertension, vasoactive peptides have been linked to cardiovascular pressure load. Here, we have explored potential associations between circulating levels of vasoactive peptides and tumor response during bevacizumab-containing treatment of colorectal cancer...
March 17, 2017: Acta Oncologica
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