Mahmood Rasool, Arif Malik, Shamaila Saleem, Muhammad Abdul Basit Ashraf, Altaf Qadir Khan, Sulayman Waquar, Ayesha Zahid, Sumaira Shaheen, Muhammad Abu-Elmagd, Kalamegam Gauthaman, Peter Natesan Pushparaj
Background: Schizophrenia is associated with a deficiency of dietary antioxidants like vitamin B6, B9, and B12 resulting in defective methylation leading to hyperhomocysteinemia. Hyperhomocysteinemia causes mitochondrial DNA damage, oxidative stress, vascular damage, and lipid peroxidation. Oxidative stress and increase in reactive oxygen species result in 8-oxodG production which induces apoptosis of both astrocytes and thyrocytes thus predisposing them to thyroid dysfunction and neurodegeneration. Furthermore, the presence of excessive free radicals increases thyroid thermogenesis causing hyperthyroidism or its excess may cause hypothyroidism by inhibiting iodide uptake...
2021: Frontiers in Pharmacology