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gammadelta t cell

S Segawa, D Goto, A Iizuka, S Kaneko, M Yokosawa, Y Kondo, I Matsumoto, T Sumida
Interstitial pneumonia (IP) is a chronic progressive interstitial lung disease associated with poor prognosis and high mortality. However, the pathogenesis of IP remains to be elucidated. The aim of this study was to clarify the role of pulmonary γδT cells in IP. In wild-type (WT) mice exposed to bleomycin, pulmonary γδT cells were expanded and produced large amounts of interferon (IFN)-γ and interleukin (IL)-17A. Histological and biochemical analyses showed that bleomycin-induced IP was more severe in T cell receptor (TCR-δ-deficient (TCRδ(-/-) ) mice than WT mice...
September 2016: Clinical and Experimental Immunology
Yoshiyuki Yamaguchi, Yousuke Katata, Makoto Okawaki, Masahiro Yamamura, Akira Sawaki
Molecular cloning of interleukin-2(IL-2)has enabled adoptive cell therapy(ACT)to be established by using autologous activated lymphocytes. The low of regenerative medicine will promote the active development of ACT for public use, and ACTs that utilize tumor-infiltrating lymphocytes(TIL), in vitro tumor-sensitized lymphocytes, natural killer T cells, and gammadelta T cells are being evaluated as advanced medical treatments in Japan. In addition, chimeric antigen receptor genemodified T(CAR-T)cells and T cell receptor gene-modified T(TCR-T)cells are available for investigational clinical use...
September 2015: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Priyanka Gaur, Ramnath Misra, Amita Aggarwal
Enthesitis related arthritis (ERA) is associated with increased frequency of Th17 cells and synovial fluid (SF) IL-17 levels. Natural killer (NK) and gamma delta T cells have been recently shown to produce IL-17, thus we studied the NK and gamma delta-T cells in peripheral blood (PB) of 50 ERA, 16 other JIA patients and 19 healthy controls. We have analyzed the frequency of NK (total, CD56dim, CD56bright) and gamma delta-T cells, perforin and KIR3DL1/2 expression on NK cells and IL-17 and IFN-gamma production by them using flow cytometry...
December 2015: Clinical Immunology: the Official Journal of the Clinical Immunology Society
Huang Xuekun, Yang Qintai, Chen Yulian, Zhang Gehua
BACKGROUD: Gammadelta-T-cells play an important role in the mucosal immune system of the respiratory tract. Th17 cells plays an important role in promoting inflammation and autoimmune diseases. Th17 cells mainly secrete IL-17. However, little information is available on the relation between gammadelta-T-cells and Th17 cells in allergic rhinitis (AR). OBJECTIVE: To explore the correlation between the prevalence of gammadelta-T-cells, the prevalence of Th17 cells and the expression of IL-17 in the peripheral blood of patients with AR...
September 2014: Asian Pacific Journal of Allergy and Immunology
Hsin-Yuan Cheng, Runpei Wu, Catherine C Hedrick
OBJECTIVE: Gammadelta (γδ) T cells are a subset of pro-inflammatory innate-like T lymphocytes that serve as a bridge between innate and adaptive immunity. γδ T cells are highly enriched in cholesterol compared to αβ T cells. In this study, we aimed to identify the role of γδ T cells in atherosclerosis, a cholesterol and inflammation-driven disease. METHODS: We found that the percentages of γδ T cells are increased in ApoE(-/-) mice fed a Western diet. We generated TCRδ(-/-)ApoE(-/-) mice and fed them either rodent chow or a Western diet for ten weeks for the assessment of atherosclerosis...
June 2014: Atherosclerosis
Alessandro Poggi, Maria Raffaella Zocchi
The role of lymphocytes in eliminating lymphoma cells is based on the interaction between activating receptors on lymphocytes and target surface ligands on lymphoma cells. Stress-related immunity can be triggered both in Hodgkin's (HL) and non-Hodgkin lymphomas (NHL), through the activation of the NKG2D receptor on CD8+ T and gammadelta T lymphocytes, by NKG2D-ligands (NKG2D-L), as the MHC class-I related molecules MIC-A/B and the UL16-binding proteins 1-4 (ULBPs), expressed on lymphoma cells. Furthermore, NKG2D-L can be shed and interact with NKG2D on effector lymphocytes affecting the recognition of lymphoma cells...
2014: Frontiers in Bioscience (Landmark Edition)
Xue-Kun Huang, Qin-Tai Yang, Yu-Lian Chen, Fu-Cheng Zhang, Ge-Hua Zhang
OBJECTIVE: To investigate the expression of peripheral blood gammadelta T cells/CD4 CD25+ regulatory T cells(Treg) and cytokines interleukin 17 (IL-17) and transforming growth factor beta1 (TGF-beta1) in patients with allergic rhinitis. METHODS: From March 2012 to July 2012, 32 patients with allergic rhinitis (AR group) and 20 healthy control subjects (control group) were collected. The expression of peripheral blood gammadelta T cells/Treg cells were measured by flow cytometry and the levels of IL-17 and TGF-beta1 were evaluated by ELISA...
July 2013: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Hsin-Yuan Cheng, Runpei Wu, Abraham K Gebre, Richard N Hanna, Dan J Smith, John S Parks, Klaus Ley, Catherine C Hedrick
Gammadelta (γδ) T lymphocytes respond quickly upon antigen encounter to produce a cytokine response. In this study, we sought to understand how functions of γδ T cells are differentially regulated compared to αβ T cells. We found that cholesterol, an integral component of the plasma membrane and a regulator of TCR signaling, is increased in γδ T cells compared to αβ T cells, and modulates their function. Higher levels of activation markers, and increased lipid raft content in γδ cells suggest that γδ T cells are more activated...
2013: PloS One
Wen Xu, Xiao-Li Wu, Yang-Xin Xie, Jun-Lian Yang, Wei-Min Nie, Min Zhao, Wei-Wei Chen
OBJECTIVE: To find out the more efficient induction method through investigating the expansion efficiencies of HIV-infected patients' Vdelta2 T cells induced by zoledronic acid (Zol) or gammadelta TCR monoclonal antibody (mAb). METHODS: 38 healthy control subjects (HC group) and 65 HIV infected patients (HIV group) were enrolled in this research. Peripheral blood mononuclear cells (PBMCs) of individuals were stimulated by Zol or gammadelta TCR mAb respectively for 14 days at 2...
December 2012: Chinese Journal of Experimental and Clinical Virology
Leonardo M R Ferreira
T cells employ a cell surface heterodimeric molecule, the T cell receptor (TCR), to recognize specific antigens (Ags) presented by major histocompatibility complex (MHC) molecules and carry out adaptive immune responses. Most T cells possess a TCR with an α and a β chain. However, a TCR constituted by a γ and a δ chain has been described, defining a novel subset of T cells. γδ TCRs specific for a wide variety of ligands, including bacterial phosphoantigens, nonclassical MHC-I molecules and unprocessed proteins, have been found, greatly expanding the horizons of T cell immune recognition...
June 2013: International Reviews of Immunology
V A Liashenko, N K Akhmatova, I V Ambrosov, S K Matelo, É A Akhmatov, A S Sukhno, V G Khomenkov
AIM: Confirmation of immunostimulating effect of an original low molecular weight germanium organic compound (LMW-GOC) during immunization of mice with Vaxigrip vaccine. MATERIALS AND METHODS: The experiments were carried out in CBA mice divided into 4 groups: control, those that received Vaxigrip influenza vaccine intraperitoneally, those that received LMW-GOC intraperitoneally and those that received both preparations at once. Effect of the preparations administered was evaluated by flow cytofluorometry based on changes of CD3, CD4, CD5, CD8, CD19, CD25, Foxp3, NK1...
November 2012: Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii
F Abebe
Bacille Calmette-Guérin (BCG), developed a century ago, is the only licensed tuberculosis (TB) vaccine in use to date. The protective efficacy of BCG against TB varies with no apparent protection in some population, and mechanisms of its immune protection is poorly known, and yet BCG is the most widely used vaccine, with more than 4 billion BCG-vaccinated children globally. BCG is probably the only licensed vaccine currently in use believed to mediate immune protection through the production of interferon (IFN)-γ by CD4 T cells, which in turn activates macrophages to kill Mycobacterium tuberculosis (Mtb)...
September 2012: Clinical and Experimental Immunology
T Maślanka, J J Jaroszewski, W Markiewicz, H Ziółkowski, D Barski
WC1+ cells in cattle exhibit both regulatory and effector activities. However, it has not been elucidated whether they are so plastic that both activities co-exist in one cell or there are separate subpopulations of effector and regulatory cells. Since the production of IFN-gamma and IL-10 seems to be related to WC1+ cells' effector and regulatory function, respectively, the main aim of this study was to determine whether those cytokines are produced by separate subpopulations of WC1+, or are co-produced by the same cells...
2012: Polish Journal of Veterinary Sciences
Sangeeta Pednekar, Vinayak Morge, Shailesh Rawal, Deepa Korivi, Vishal Ramteke, Kiran Naik
We report a case of 18 year old male who presented with hepatosplenomegaly, anemia and thrombocytopenia. His complete hemogram, peripheral smear, bone marrow studies were inconclusive. On immunophenotyping he was diagnosed as "Hepatosplenic gamma delta (gammadelta) T cell lymphoma" which is a very rare variety of T cell lymphoma. Less than 100 cases have been described in the literature since the entity was first described in 1990.
October 2011: Journal of the Association of Physicians of India
Chun-Rong Tong, Hui Wang, Yue-Hui Lin, Jun-Fang Yang, Jie Zhao, Xian Zhang, Yu-Ming Yin, Xin-Hong Fei, Ping Wu, Tong Wang, Hong-Xing Liu, Peng Cai, Zhi-Jie Wei, Juan Xiao, De-Yan Liu, Min Xiong, Jing Zhong, Dao-Pei Lu
OBJECTIVE: To analyze the clinical and laboratory features of 9 cases of gammadeltaT cell lymphoma or leukemia. METHODS: From 2007 to 2011, 9 patients with gammadeltaT-cell lymphoma/leukemia were diagnosed in our hospital. The immunophenotype of the abnormal cells were detected by flow cytometry, clonal gene rearrangement of IgH, TCRgamma, TCRdelta by PCR, chromosome karyotype analysis by G banding, acute leukemia gene and the DNA of type 1 - 8 human herpes virus by multiple nested PCR, The gammadeltaT cells were determined by T cell with TCR gammadelta chain, the malignant gammadelta T cells by the abnormal expression of T cell antigens and the precursor malignant gammadelta T cells by the expression of CD34, TDT, CD99, CD1 a or acute leukemia genes...
July 2011: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
D Fenoglio, M R Zocchi, A Parodi, P Durando, G Gabutitp, R Gasparini, A Poggi
INTRODUCTION: We previously reported that in HIV-1 infected patients circulating Vdelta1 T lymphocytes (Vdelta1) increase and proliferate in vitro in response to Candida albicans (Ca). Herein, we analysed the effects of MF59 adjuvant on the Vdelta1 T cell responses to hemagglutinin (HA) and Ca in HIV-1 seropositive and seronegative adults after influenzal vaccine, to clarify th molecular mechanisms triggered in vivo by an adjuvanted vaccine against influenza virus. MATERIALS AND METHODS: 58 seropositive (HIV-1+) and 48 seronegative (HIV-1-) subjects received influenzal vaccines containing or not the MF59 adjuvant...
September 2011: Journal of Preventive Medicine and Hygiene
Stephanie Kadow, Bettina Jux, Sonja P Zahner, Britta Wingerath, Stefanie Chmill, Björn E Clausen, Jan Hengstler, Charlotte Esser
An immunoregulatory role of aryl hydrocarbon receptor (AhR) has been shown in conventional αβ and γδ T cells, but its function in skin γδ T cells (dendritic epidermal T cells [DETC]) is unknown. In this study, we demonstrate that DETC express AhR in wild-type mice, and are specifically absent in the epidermis of AhR-deficient mice (AhR-KO). We show that DETC precursors are generated in the thymus and home to the skin. Proliferation of DETC in the skin was impaired in AhR-KO mice, resulting in a >90% loss compared with wild type...
September 15, 2011: Journal of Immunology: Official Journal of the American Association of Immunologists
Allison R Kazen, Erin J Adams
γδ T cells are an immunological enigma in that both their function in the immune response and the molecular mechanisms behind their activation remain unclear. These cells predominate in the epithelia and can be rapidly activated to provide an array of responses. However, no homologous γδ T-cell populations have been identified between humans and mice, and our understanding of what these cells recognize as ligands is limited. Here we take an alternative approach to understanding human γδ T-cell ligand recognition by studying the evolutionary forces that have shaped the V, D, and J gene segments that are used during somatic rearrangement to generate the γδ T-cell receptor...
July 19, 2011: Proceedings of the National Academy of Sciences of the United States of America
Wenwei Tu, Jian Zheng, Yinping Liu, Sin Fun Sia, Ming Liu, Gang Qin, Iris H Y Ng, Zheng Xiang, Kwok-Tai Lam, J S Malik Peiris, Yu-Lung Lau
There are few antiviral drugs for treating influenza, and the emergence of antiviral resistance has further limited the available therapeutic options. Furthermore, antivirals are not invariably effective in severe influenza, such as that caused by H5N1 viruses. Thus, there is an urgent need to develop alternative therapeutic strategies. Here, we show that human Vγ9Vδ2 T cells expanded by the aminobisphosphonate pamidronate (PAM) kill influenza virus-infected cells and inhibit viral replication in vitro. In Rag2(-/-)γc(-/-) immunodeficient mice reconstituted with human peripheral mononuclear cells (huPBMCs), PAM reduces disease severity and mortality caused by human seasonal H1N1 and avian H5N1 influenza virus, and controls the lung inflammation and viral replication...
July 4, 2011: Journal of Experimental Medicine
A Sheikha, M Aljanadi, M Alshehri, S Raziuddin
Because of the recent evidence of involvement of cytokines in the inflammatory processes, cellular proliferation and host defence mechanism, we have measured the in vitro production of interferon-gamma (IFN-gamma), interleukin (IL)-4, IL-6 and tumor necrosis factor-alpha (TNFalpha) from the phenotypically and histologically characterized ten peripheral T cell lymphoma (PTCL) cases. The immunophenotypic study had identified three gammadelta PTCL cases (CD3-CD4+CD8+, one case and CD3+CD4-CD8, two cases). Mononuclear cells obtained from the lymph node cells of PTCL cases, irrespective of histologic type, were found to produce highly elevated levels of IFN-gamma and IL-6 both spontaneously and in response to concanavalin A stimulations...
January 1994: International Journal of Oncology
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