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https://www.readbyqxmd.com/read/29141316/-a-clinical-analysis-of-micafungin-treatment-of-pulmonary-invasive-fungal-infection-in-pediatric-patients-with-acute-leukemia-or-post-hematopoietic-stem-cells-transplantation
#1
K Huang, K Y Qiu, L L Deng, J P Fang, Y Li, H X Guo, D H Zhou
Objective: To investigate the efficacy and safety of micafungin (MCF) for pulmonary invasive fungal disease (PIFD) in pediatric patients with acute leukemia or post hematopoietic stem cells transplantation. Method: Twenty-five neutropenic PIFD children with acute leukemia or post hematopoietic stem cells transplantation in Sun Yat-sen Memorial Hospital of Sun Yat-sen University were selected from January 2012 to June 2015, including 12 males and 13 females, age range 2-15 (average 6.2±2.0) years. There were 12 cases of acute leukemia (AL) after chemotherapy, 4 cases of acute leukemia (AL) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and 9 cases of β-thalassemia major after allo-HSCT...
November 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29125713/outbreak-of-invasive-aspergillosis-in-heart-transplant-recipients-the-role-of-screening-computed-tomography-scans-in-asymptomatic-patients-and-universal-antifungal-prophylaxis
#2
Dima Kabbani, Livia Goldraich, Heather Ross, Coleman Rotstein, Shahid Husain
BACKGROUND: Delays in diagnosing invasive pulmonary aspergillosis (IA), a significant cause of morbidity and mortality among heart transplant recipients (HTRs), may impact on successful treatment. The appropriate screening strategy for IA in these patients remains undefined, particularly in the setting of nosocomial outbreaks. We describe our experience employing chest computed tomography (CT) scans as a screening method for IA. In addition, we comment on antimicrobial prophylaxis in HTRs in the setting of an outbreak...
November 10, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29125373/use-of-1-3-%C3%AE-d-glucan-in-invasive-fungal-diseases-in-hematology-patients
#3
Daniele Roberto Giacobbe, Valerio Del Bono, Claudio Viscoli, Malgorzata Mikulska
Invasive fungal diseases (IFD) remain a leading cause of morbidity and mortality in hematology patients. Within a diagnostic-driven approach, the use of the serum (1,3)-ß-D-glucan (BDG) test represents a valid tool for the early diagnosis and treatment of IFD. Areas covered: The available literature on the use of BDG in hematology patients was systematically retrieved. Then, it was reviewed and discussed, to identify key issues pertaining to a clinically-oriented narrative presentation of the topic. Expert commentary: The use of BDG in hematology patients at risk for invasive aspergillosis (IA) is secondary to the use of galactomannan...
November 10, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29121338/efficacy-of-%C3%AE-mannanase-on-broiler-growth-performance-and-energy-utilization-in-the-presence-of-increasing-dietary-galactomannan
#4
R E Latham, M P Williams, H G Walters, B Carter, J T Lee
An experiment was conducted to investigate the impact of β-mannanase inclusion on growth performance, viscosity, and energy utilization in broilers fed diets varying in galactomannan (GM) concentrations. Treatments were arranged as a 3 (GM concentration) × 3 (β-mannanase inclusion) factorial randomized complete block design with 12 replicates of 29 male broilers per replicate for a 42-d experiment. Efforts were made to reduce the amount of soybean meal, and thus GM, in the basal diet with guar gum included at 0, 0...
November 7, 2017: Poultry Science
https://www.readbyqxmd.com/read/29120386/high-quality-unigenes-and-microsatellite-markers-from-tissue-specific-transcriptome-and-development-of-a-database-in-clusterbean-cyamopsis-tetragonoloba-l-taub
#5
Hukam C Rawal, Shrawan Kumar, Amitha Mithra S V, Amolkumar U Solanke, Deepti Nigam, Swati Saxena, Anshika Tyagi, Sureshkumar V, Neelam R Yadav, Pritam Kalia, Narendra Pratap Singh, Nagendra Kumar Singh, Tilak Raj Sharma, Kishor Gaikwad
Clusterbean (Cyamopsis tetragonoloba L. Taub), is an important industrial, vegetable and forage crop. This crop owes its commercial importance to the presence of guar gum (galactomannans) in its endosperm which is used as a lubricant in a range of industries. Despite its relevance to agriculture and industry, genomic resources available in this crop are limited. Therefore, the present study was undertaken to generate RNA-Seq based transcriptome from leaf, shoot, and flower tissues. A total of 145 million high quality Illumina reads were assembled using Trinity into 127,706 transcripts and 48,007 non-redundant high quality (HQ) unigenes...
November 9, 2017: Genes
https://www.readbyqxmd.com/read/29114397/false-positive-galactomannan-assay-in-broncho-alveolar-lavage-after-enteral-nutrition-solution-inhalation-a-case-report
#6
Olivier Lheureux, Isabel Montesinos, Olivier Taton, Martine Antoine, Jean-Charles Preiser, Joelle Nortier, Jacques Creteur, Frederique Jacobs, David Grimaldi
Introduction. Diagnosis of invasive aspergillosis is challenging and the gold standard for definite diagnosis remains histopathological tissue examination. However, invasive procedures such as lung biopsy are often not feasible in critically ill patients. The detection of fungal cell wall components like Aspergillus galactomannan in broncho-alveolar lavage remains a key component of the diagnostic procedure. False-positive of the Aspergillus galactomannan assay is not frequent. Case presentation. We report a case of positive galactomannan in broncho-alveolar lavage fluid after enteral nutrition aspiration without signs of invasive aspergillosis...
September 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29108709/update-on-actinomucor-elegans-a-mucormycete-infrequently-detected-in-human-specimens-how-combined-microbiological-tools-contribute-efficiently-to-a-more-accurate-medical-care
#7
J Dorin, M D'Aveni, A Debourgogne, M Cuenin, M Guillaso, A Rivier, P Gallet, G Lecoanet, M Machouart
Actinomucor elegans is a fungus belonging to mucormycetes and is still probably underdiagnosed due to misidentification. Based on a recent first case of Actinomucor elegans sinusitis in Europe, in an immunocompromised patient under voriconazole treatment, this paper aims to summarize knowledge about A. elegans mucormycoses. Even if the diagnosis of mucormycosis was made using traditional mycology techniques, precise identification of the fungus could only be achieved using molecular tools. In this observation, the galactomannan dosage was positive until the introduction of treatment and surgical debridement...
October 26, 2017: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/29103525/extraction-purification-and-characterization-of-galactomannan-from-fenugreek-for-industrial-utilization
#8
Farhat Rashid, Sarfraz Hussain, Zaheer Ahmed
Galactomannan, a water-soluble heteropolysaccharide was isolated and purified from seed of fenugreek locally called as Kasuri Methi. Polysaccharide was chemically characterized and its functional attributes were studied in detail. FTIR analysis divulges representative peaks of polysaccharide in region of 3324, 2914 & 1653cm(-1). Galactomannan depicted lower water holding capacity compared to guar gum. Emulsifying activity and emulsion stability of biopolymer was on higher side as compare to reference material...
January 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29081774/immunobiological-activity-of-synthetically-prepared-immunodominant-galactomannosides-structurally-mimicking-aspergillus-galactomannan
#9
Ema Paulovičová, Lucia Paulovičová, Martin Hrubiško, Vadim B Krylov, Dmitry A Argunov, Nikolay E Nifantiev
The study is oriented at the in vitro evaluation of the immunobiological activity and efficacy of synthetically prepared isomeric pentasaccharides representing fragments of Aspergillus fumigatus cell-wall galactomannan and containing β-(1→5)-linked tetragalactofuranoside chain attached to O-6 (GM-1) or O-3 (GM-2) of a spacer-armed mannopyranoside residue. These compounds were studied as biotinylated conjugates which both demonstrated immunomodulatory activities on the RAW 264.7 cell line murine macrophages as in vitro innate immunity cell model...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29053819/changes-in-immune-and-metabolic-gut-response-in-broilers-fed-%C3%AE-mannanase-in-%C3%AE-mannan-containing-diets
#10
R J Arsenault, J T Lee, R Latham, B Carter, M H Kogut
β-galactomannans found in soy-based broiler feed are known to cause physiological effects that are hypothesized to be related to gut inflammation. Previous studies have shown that the incorporation of β-mannanase in the diet or as a supplement results in improvements to certain performance parameters related to gut health and feed conversion. Using kinome analysis, we characterized the mechanism of β-galactomannan activity and supplementation with β-mannanase on the gut of commercial broilers to understand the mode of action...
September 14, 2017: Poultry Science
https://www.readbyqxmd.com/read/29036605/survey-of-laboratory-practices-for-diagnosis-of-fungal-infection-in-seven-asian-countries-an-asia-fungal-working-group-afwg-initiative
#11
Ariya Chindamporn, Arunaloke Chakrabarti, Ruoyu Li, Pei-Lun Sun, Ban-Hock Tan, Mitzi Chua, Retno Wahyuningsih, Atul Patel, Zhengyin Liu, Yee-Chun Chen, Methee Chayakulkeeree
An online survey of mycology laboratories in seven Asian countries was conducted to assess the status, competence, and services available. Country representatives from the Asia Fungal Working Group (AFWG) contacted as many laboratories performing mycology diagnosis as possible in their respective countries, requesting that the laboratory heads complete the online survey. In total, 241 laboratories responded, including 71 in China, 104 in India, 11 in Indonesia, 26 in the Philippines, four in Singapore, 18 in Taiwan, and seven in Thailand...
September 20, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29028116/effect-of-%C3%AE-mannanase-domain-from-trichoderma-reesei-on-its-biochemical-characters-and-synergistic-hydrolysis-of-sugarcane-bagasse
#12
Lijuan Ma, Qing Ma, Rui Cai, Zhiyou Zong, Liping Du, Gaojie Guo, Yingying Zhang, Dongguang Xiao
BACKGROUND: β-mannanase is a key enzyme for hydrolyzing mannan, a major composition of hemicellulose which is the second most abundant polysaccharides in nature. Different structural domains greatly affect its biochemical characters and catalytic efficiency. But the effects of linker and CBM on β-mannanase from Trichoderma reesei (Man1) have not yet been fully described. This study aimed to elucidate the influence of different domains on expression efficiency, biochemical characteristics and hemicellulosic deconstruction of Man1...
October 13, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29020213/improvement-in-diagnosis-of-histoplasma-meningitis-by-combined-testing-for-histoplasma-antigen-and-igg-and-igm-anti-histoplasma-antibody-in-cerebrospinal-fluid
#13
Karen C Bloch, Thein Myint, Luke Raymond-Guillen, Chadi A Hage, Thomas E Davis, Patty W Wright, Felicia C Chow, Laila Woc-Colburn, Raed N Khairy, Alan C Street, Tomotaka Yamamoto, Amanda Albers, L Joseph Wheat
Background: Central nervous system (CNS) histoplasmosis is a life-threatening condition and represents a diagnostic and therapeutic challenge. Isolation of H. capsulatum from cerebrospinal fluid (CSF) or brain tissue is diagnostic; however, culture is insensitive and slow growth may result in significant treatment delay. We performed a retrospective multicenter study to evaluate the sensitivity and specificity of a new anti-Histoplasma antibody enzyme immunoassay (EIA) for the detection of IgG and IgM antibody in the CSF for diagnosis of CNS histoplasmosis, the primary objective of the study...
August 20, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28993009/fenugreek-galactomannan-and-citrus-pectin-improve-several-parameters-associated-with-glucose-metabolism-and-modulate-gut-microbiota-in-mice
#14
Miriam G Shtriker, Michal Hahn, Elise Taieb, Abraham Nyska, Uzi Moallem, Oren Tirosh, Zecharia Madar
OBJECTIVE: Galactomannans derived from fenugreek confer known health benefits; however, there is little information regarding health benefits of citrus pectin (CP) and its association with gut microbiome metabolites. The aim of this study was to examine links between galactomannan and CP consumption, microbiota development, and glucose metabolism. DESIGN: Male C57 BL/6 J mice ages 7 to 8 wk were fed ad libitum with a normal diet or one supplemented with 15% of either galactomannan or CP...
August 3, 2017: Nutrition
https://www.readbyqxmd.com/read/28986661/-aspergillus-in-airway-material-ignore-or-treat
#15
REVIEW
H J F Salzer, C Lange, M Hönigl
Fungi of the genus Aspergillus are ubiquitously present. Even though humans inhale Aspergillus spores daily under natural conditions, Aspergillus-associated pulmonary diseases only occur under special circumstances. Whether an Aspergillus-associated disease develops and which type of Aspergillus-associated disease develops depends on the constitution of the host. The spectrum of Aspergillus-associated pulmonary diseases ranges from allergic diseases, such as hypersensitivity pneumonitis to allergic infectious diseases, such as allergic bronchopulmonary aspergillosis (ABPA) and bronchocentric granulomatosis (BG) to infectious diseases, such as invasive (IA) or semi-invasive aspergillosis (SIA) and chronic pulmonary aspergillosis (CPA)...
November 2017: Der Internist
https://www.readbyqxmd.com/read/28973595/aspergillus-galactomannan-for-diagnosing-invasive-aspergillosis
#16
Marisa H Miceli, Carol A Kauffman
No abstract text is available yet for this article.
September 26, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28970160/aspergillus-galactomannan-detection-in-exhaled-breath-condensate-compared-to-bronchoalveolar-lavage-fluid-for-the-diagnosis-of-invasive-aspergillosis-in-immunocompromised-patients
#17
Alyajahan Bhimji, Archana Bhaskaran, Lianne G Singer, Deepali Kumar, Atul Humar, Rhea Pavan, Jeffrey Lipton, John Kuruvilla, Andre Schuh, Karen Yee, Mark D Minden, Aaron Schimmer, Coleman Rotstein, Shaf Keshavjee, Tony Mazzulli, Shahid Husain
OBJECTIVE: Exhaled breath condensate (EBC) is a noninvasive means of sampling the airways that has shown significant promise in the diagnosis of many disorders. There have been no reports of its utility for the detection of galactomannan (GM), a component of the cell wall of Aspergillus. The suitability of EBC for the detection of GM for the diagnosis of invasive aspergillosis (IA) using the Platelia(®)Aspergillus enzyme-linked immunosorbent assay (ELISA) was investigated. METHODS: Prospective, cross-sectional study of lung transplant recipient and hematological malignancy patients at a university center...
September 29, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28968675/pharmacodynamics-of-the-novel-antifungal-agent-f901318-for-acute-sinopulmonary-aspergillosis-caused-by-aspergillus-flavus
#18
Clara E Negri, Adam Johnson, Laura McEntee, Helen Box, Sarah Whalley, Julie A Schwartz, V Ramos-Martín, Joanne Livermore, Ruwanthi Kolamunnage-Dona, Arnaldo L Colombo, William W Hope
Background: Aspergillus flavus is one of the most common agents of invasive aspergillosis and is associated with high mortality. The orotomides are a new class of antifungal agents with a novel mechanism of action. An understanding of the pharmacodynamics of the lead compound F901318 is required to plan safe and effective regimens for clinical use. Methods: The pharmacokinetics (PK) and pharmacodynamics (PD) of F901318 were evaluated by developing new in vitro and in vivo models of invasive fungal sinusitis...
September 12, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28967216/temperature-dependency-of-the-interaction-between-xanthan-gum-and-sage-seed-gum-an-interpretation-of-dynamic-rheology-and-thixotropy-based-on-creep-test
#19
Seyed M A Razavi, Fataneh Behrouzian, Ali Alghooneh
The viscoelastic (transient and dynamic) and time-dependent rheological behaviors of XG (xanthan gum), SSG (sage seed gum) and their blends at various ratios (1-3, 1-1, and 3-1 SSG-XG) and temperatures (10, 30, and 50C) were investigated using creep and recovery analyses. The creep compliance was converted to stress relaxation data; then, the structural kinetic model satisfactorily fitted the time-dependent relaxation modulus. Furthermore, dynamic rheology of mixtures was investigated using creep analyses. The most important contribution of the Maxwell spring to deformation (53...
October 2017: Journal of Texture Studies
https://www.readbyqxmd.com/read/28966482/comparative-evaluation-of-galactomannan-test-with-bronchoalveolar-lavage-and-serum-for-the-diagnosis-of-invasive-aspergillosis-in-patients-with-hematological-malignancies
#20
Ankit Gupta, Malini R Capoor, Trupti Shende, Bhawna Sharma, Ritin Mohindra, Jagdish Chander Suri, Dipender Kumar Gupta
INTRODUCTION: Invasive pulmonary aspergillosis (IPA) is a major cause of morbidity and mortality in patients with hematological malignancies. In recent years, testing for values of galactomannan (GM) in serum and bronchoalveolar lavage (BAL) fluid has been investigated as a diagnostic test for IPA for such patients, but global experience and consensus on optical density (OD) cutoffs, especially for BAL galactomannan remains lacking. METHODS: We performed a prospective case-control study to determine an optimal BAL GM OD cutoff for IPA in at-risk patients...
October 2017: Journal of Laboratory Physicians
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