keyword
https://read.qxmd.com/read/38536006/downregulating-mirna-199a-5p-exacerbates-fluorouracil-induced-cardiotoxicity-by-activating-the-atf6-signaling-pathway
#1
JOURNAL ARTICLE
Wei Wang, Liang Dong, Hengxu Lv, Yonghui An, Changwang Zhang, Zheng Zheng, Ying Guo, Li He, Libin Wang, Jinmei Wang, Xinlei Shi, Na Li, Mingqi Zheng
BACKGROUND: Fluorouracil (5-FU) might produce serious cardiac toxic reactions. miRNA-199a-5p is a miRNA primarily expressed in myocardial cells and has a protective effect on vascular endothelium. Under hypoxia stress, the expression level of miRNA-199a-5p was significantly downregulated and is closely related to cardiovascular events such as coronary heart disease, heart failure, and hypertension. We explored whether 5-FU activates the endoplasmic reticulum stress ATF6 pathway by regulating the expression of miRNA-199a-5p in cardiac toxicity...
March 25, 2024: Aging
https://read.qxmd.com/read/38534758/autophagy-dependent-secretion-crosstalk-between-autophagy-and-exosome-biogenesis
#2
REVIEW
Ekaterina Zubkova, Alexander Kalinin, Anastasya Bolotskaya, Irina Beloglazova, Mikhail Menshikov
The cellular secretome is pivotal in mediating intercellular communication and coordinating responses to stressors. Exosomes, initially recognized for their role in waste disposal, have now emerged as key intercellular messengers with significant therapeutic and diagnostic potential. Similarly, autophagy has transcended its traditional role as a waste removal mechanism, emerging as a regulator of intracellular communication pathways and a contributor to a unique autophagy-dependent secretome. Secretory authophagy, initiated by various stress stimuli, prompts the selective release of proteins implicated in inflammation, including leaderless proteins that bypass the conventional endoplasmic reticulum-Golgi secretory pathway...
March 8, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534743/effects-of-letrozole-treatment-and-vitamin-c-supplementation-on-morphology-endoplasmic-reticulum-stress-programmed-cell-death-and-oxidative-stress-in-the-small-intestine-of-adult-male-rats
#3
JOURNAL ARTICLE
Anna Pilutin, Sylwia Rzeszotek, Aleksandra Wilk, Klaudia Klimaszewska, Julia Łukasiewicz, Rufaro Lynnette Mafuta, Thanushan Nagendran, Rupia Ndambara, Barbara Wiszniewska
Estrogens are hormones that play an important role in the digestive tract, including in men. Letrozole is an inhibitor of cytochrome P450 aromatase, an enzyme converting androgens to estrogens. The use of letrozole may cause oxidative stress and endoplasmic reticulum stress in the cells. Factors modulating cellular stress may include vitamin C. The purpose of this study was to examine whether letrozole and/or vitamin C supplementation can affect the morphology of the small intestine, the parameters of endoplasmic reticulum stress, programmed cell death markers, and oxidative damage...
March 1, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534732/induction-of-endoplasmic-reticulum-stress-by-prodigiosin-in-yeast-saccharomyces-cerevisiae
#4
JOURNAL ARTICLE
Sy Le Thanh Nguyen, Thi Hien Trang Nguyen, Thi Tuyen Do, Thi Thao Nguyen, Thanh Hoang Le, Thi Anh Tuyet Nguyen, Yukio Kimata
Prodigiosin, a red pigment produced by numerous bacterial species, exerts various antibiotic effects on prokaryotic and eukaryotic organisms. For instance, human carcinoma cell lines appear to suffer from endoplasmic reticulum (ER) stress in the presence of prodigiosin. Here, we demonstrated that prodigiosin also triggers the unfolded-protein response (UPR), which is a cytoprotective response against ER stress, in yeast Saccharomyces cerevisiae . An S. cerevisiae mutant carrying a UPR-deficient mutation was hypersensitive to prodigiosin...
February 26, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534475/enhancing-antibody-specific-productivity-unraveling-the-impact-of-xbp1s-overexpression-and-glutamine-availability-in-sp2-0-cells
#5
JOURNAL ARTICLE
Priscilla González-Pereira, Ryan Trinh, Alex Vasuthasawat, Angelo Bartsch-Jiménez, Constanza Nuñez-Soto, Claudia Altamirano
Augmentation of glycoprotein synthesis requirements induces endoplasmic reticulum (ER) stress, activating the unfolded protein response (UPR) and triggering unconventional XBP1 splicing. As a result, XBP1s orchestrates the expression of essential genes to reduce stress and restore homeostasis. When this mechanism fails, chronic stress may lead to apoptosis, which is thought to be associated with exceeding a threshold in XBP1s levels. Glycoprotein assembly is also affected by glutamine (Gln) availability, limiting nucleotide sugars (NS), and preventing compliance with the increased demands...
February 21, 2024: Bioengineering
https://read.qxmd.com/read/38534366/steroidogenesis-upregulation-through-mitochondria-associated-endoplasmic-reticulum-membranes-and-mitochondrial-dynamics-in-rat-testes-the-role-of-d-aspartate
#6
JOURNAL ARTICLE
Debora Latino, Massimo Venditti, Sara Falvo, Giulia Grillo, Alessandra Santillo, Imed Messaoudi, Mariem Ben Rhouma, Sergio Minucci, Gabriella Chieffi Baccari, Maria Maddalena Di Fiore
Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs) mediate the communication between the Endoplasmic Reticulum (ER) and the mitochondria, playing a fundamental role in steroidogenesis. This study aimed to understand how D-aspartate (D-Asp), a well-known stimulator of testosterone biosynthesis and spermatogenesis, affects the mechanism of steroidogenesis in rat testes. Our results suggested that D-Asp exerts this function through MAMs, affecting lipid trafficking, calcium signaling, ER stress, and mitochondrial dynamics...
March 16, 2024: Cells
https://read.qxmd.com/read/38533111/a-transcriptomic-dataset-for-investigating-the-arabidopsis-unfolded-protein-response-under-chronic-proteotoxic-endoplasmic-reticulum-stress
#7
JOURNAL ARTICLE
Amélie Ducloy, Marianne Azzopardi, Caroline Ivsic, Gwendal Cueff, Delphine Sourdeval, Delphine Charif, Jean-Luc Cacas
The Unfolded Protein Response (UPR) is a retrograde, ER-to-nucleus, signalling pathway which is conserved across kingdoms. In plants, it contributes to development, reproduction, immunity and tolerance to abiotic stress. This RNA sequencing (RNA-seq) dataset was produced from 14-day-old Arabidopsis thaliana seedlings challenged by tunicamycin (Tm), an antibiotic inhibiting Asn-linked glycosylation in the endoplasmic reticulum (ER), causing an ER stress and eventually activating the UPR. Wild-type (WT) and a double mutant deficient for two main actors of the UPR ( INOSITOL-REQUIRING ENZYME 1A and INOSITOL-REQUIRING ENZYME 1B ) were used as genetic backgrounds in our experimental setup, allowing to distinguish among differentially-expressed genes (DEGs) which ones are dependent on or independent on IRE1s...
April 2024: Data in Brief
https://read.qxmd.com/read/38531909/preso-enhances-mglur1-mediated-excitotoxicity-by-modulating-the-phosphorylation-of-mglur1-homer1-complex-and-facilitating-an-er-stress-after-traumatic-brain-injury
#8
JOURNAL ARTICLE
Zhuoyuan Zhang, Xiangyu Gao, Zhicheng Tian, Erwan Yang, Yutao Huang, Dan Liu, Shuhui Dai, Haofuzi Zhang, Mingdong Bao, Xiaofan Jiang, Xin Li, Peng Luo
Glutamate receptor (GluR)-mediated excitotoxicity is an important mechanism causing delayed neuronal injury after traumatic brain injury (TBI). Preso, as a core scaffolding protein of postsynaptic density (PSD), is considered an important regulator during excitotoxicity and TBI and combines with glutamate receptors to form functional units for excitatory glutamatergic neurotransmission, and elucidating the mechanisms of these functional units will provide new targets for the treatment of TBI. As a multidomain scaffolding protein, Preso directly interacts with metabotropic GluR (mGluR) and another scaffold protein, Homer...
March 26, 2024: Cell Death Discovery
https://read.qxmd.com/read/38531904/social-defeat-stress-induces-liver-injury-by-modulating-endoplasmic-reticulum-stress-in-c57bl-6j-mice
#9
JOURNAL ARTICLE
XiaoLei Gao, Tong Zhao, Ran Hao, ZhaoHui Zhang, Guang-Biao Huang
Social defeat stress is associated with endoplasmic reticulum (ER) stress, inflammation and apoptosis. ER stress is thought to contribute to many lifestyle diseases such as liver injury, cardiovascular dysfunction and depression. We investigated the expression of the ER stress markers RNA-dependent protein kinase-like ER kinase (PERK), eukaryotic translation initiation factor 2α (eIF2α) and C/EBP homologous protein (CHOP), as well as inflammatory and apoptotic factors, to assess how social defeat stress induces liver injury...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531832/molecular-mechanisms-involved-in-alcohol-craving-irf3-and-endoplasmic-reticulum-stress-a-multi-omics-study
#10
JOURNAL ARTICLE
Ming-Fen Ho, Cheng Zhang, Irene Moon, Mustafa Tuncturk, Brandon J Coombes, Joanna Biernacka, Michelle Skime, Tyler S Oesterle, Victor M Karpyak, Hu Li, Richard Weinshilboum
Alcohol use disorder (AUD) is the most prevalent substance use disorder worldwide. Acamprosate and naltrexone are anti-craving drugs used in AUD pharmacotherapy. However, molecular mechanisms underlying their anti-craving effect remain unclear. This study utilized a patient-derived induced pluripotent stem cell (iPSC)-based model system and anti-craving drugs that are used to treat AUD as "molecular probes" to identify possible mechanisms associated with alcohol craving. We examined the pathophysiology of craving and anti-craving drugs by performing functional genomics studies using iPSC-derived astrocytes and next-generation sequencing...
March 26, 2024: Translational Psychiatry
https://read.qxmd.com/read/38531818/inhibition-of-the-endoplasmic-reticulum-stress-associated-ire-1-pathway-alleviates-preterm-birth
#11
JOURNAL ARTICLE
Liyin Qiu, Hui Liu, Shali Chen, Yiting Wu, Jianying Yan
BACKGROUND: Premature birth (PTB) remains a major global health concern due to its association with neonatal morbidity and mortality. The unfolded protein response (UPR) within the endoplasmic reticulum (ER) is tightly regulated by Inositol-requiring enzyme type 1 (IRE-1), a pivotal cellular modulator. This study seeks to elucidate the role of the ER stress (ERS)-related IRE-1 pathway in PTB. METHODS: Human placental trophoblast cells HTR8/Svneo were exposed to the ER-stress inducer tunicamycin (TM)...
March 2024: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/38531791/melatonin-s-protective-effects-on-neurons-in-an-in-vitro-cell-injury-model
#12
JOURNAL ARTICLE
Wei Gu, Mimi Wu, Shihe Cui, Jinhua Bo, Hao Wu
BACKGROUND: Currently, the role of melatonin (MT) in neuronal damage remains unclear and this study aimed to explore the protective effects of MT on neurons in an in vitro cell injury model. METHODS: The Sprague Dawley (SD) rat traumatic brain injury (TBI) model was prepared, and brain tissue extract (BTE) from the injured area were generated. To establish a cell injury model in vitro , the BTE was added to the culture medium during the neuron culture process. MT was introduced into the culture medium of the cell injury model to observe its protective effects on neurons...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531484/inhibition-of-soluble-epoxide-hydrolase-as-a-therapeutic-approach-for-blood-brain-barrier-dysfunction
#13
JOURNAL ARTICLE
Shuo Li, Huijia Song, Yanping Sun, Yongjun Sun, Huimin Zhang, Zibin Gao
The blood-brain barrier (BBB) is a protective semi-permeable structure that regulates the exchange of biomolecules between the peripheral blood and the central nervous system (CNS). Due to its specialized tight junctions and low vesicle trafficking, the BBB strictly limits the paracellular passage and transcellular transport of molecules to maintain the physiological condition of brain tissues. BBB breakdown is associated with many CNS disorders. Soluble epoxide hydrolase (sEH) is a hydrolase enzyme that converts epoxy-fatty acids (EpFAs) to their corresponding diols and is involved in the onset and progression of multiple diseases...
March 24, 2024: Biochimie
https://read.qxmd.com/read/38531462/edaravone-counteracts-redox-and-metabolic-disruptions-in-an-emerging-zebrafish-model-of-sporadic-als
#14
JOURNAL ARTICLE
Nuno A S Oliveira, Brígida R Pinho, Joana Pinto, Paula Guedes de Pinho, Jorge M A Oliveira
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease in which the death of motor neurons leads to loss of muscle function. Additionally, cognitive and circadian disruptions are common in ALS patients, contributing to disease progression and burden. Most ALS cases are sporadic, and environmental exposures contribute to their aetiology. However, animal models of these sporadic ALS cases are scarce. The small vertebrate zebrafish is a leading organism to model neurodegenerative diseases; previous studies have proposed bisphenol A (BPA) or β-methylamino-l-alanine (BMAA) exposure to model sporadic ALS in zebrafish, damaging motor neurons and altering motor responses...
March 24, 2024: Free Radical Biology & Medicine
https://read.qxmd.com/read/38530053/sinapic-acid-protects-against-lead-acetate-induced-lung-toxicity-by-reducing-oxidative-stress-apoptosis-inflammation-and-endoplasmic-reticulum-stress-damage
#15
JOURNAL ARTICLE
Nurhan Akaras, Sefa Kucukler, Cihan Gur, Mustafa Ileriturk, Fatih Mehmet Kandemir
Lead acetate (PbAc) is a compound that produces toxicity in many tissues after exposure. Sinapic acid (SNP) possesses many biological and pharmacological properties. This study aimed to investigate the efficacy of SNP on the toxicity of PbAc in lung tissue. PbAc was administered orally at 30 mg/kg and SNP at 5 or 10 mg/kg for 7 days. Biochemical, genetic, and histological methods were used to investigate inflammatory, apoptotic, endoplasmic reticulum stress, and oxidative stress damage levels in lung tissue...
March 26, 2024: Environmental Toxicology
https://read.qxmd.com/read/38528189/identification-of-hdac9-and-arrdc4-as-potential-biomarkers-and-targets-for-treatment-of-type-2-diabetes
#16
JOURNAL ARTICLE
Jing Liu, Lingzhen Meng, Zhihong Liu, Ming Lu, Ruiying Wang
We aimed to identify the key potential insulin resistance (IR)-related genes and investigate their correlation with immune cell infiltration in type 2 diabetes (T2D). The GSE78721 dataset (68 diabetic patients and 62 controls) was downloaded from the Gene Expression Omnibus database and utilized for single-sample gene set enrichment analysis. IR-related genes were obtained from the Comparative Toxicology Genetics Database, and the final IR-differentially expressed genes (DEGs) were screened by intersecting with the DEGs obtained from the GSE78721 datasets...
March 25, 2024: Scientific Reports
https://read.qxmd.com/read/38527981/cyclophosphamide-stimulates-endoplasmic-reticulum-stress-and-induces-apoptotic-cell-death-in-human-glioblastoma-cell-lines
#17
JOURNAL ARTICLE
Mustafa Oztatlici, Hulya Oztatlici, Suna Karadeniz Saygili, Ismail Kaya, Ilker Deniz Cingoz
Cyclophosphamide (CP) is an alkylating chemotherapeutic agent commonly used in cancer treatments. In this study, we aimed to investigate the effects of 4-Hydroperoxy cyclophosphamide (4-HC), which is active form of CP, on glucose-regulated protein 78 (GRP78), activating transcription factor 6 (ATF6), phospho-protein kinase R (PKR)-like endoplasmic reticulum (ER) kinase (p-PERK), phospho-inositol-requiring enzyme 1 alpha (p-IRE1α), eukaryotic translation initiation factor 2 alpha (eIF2α), and caspase-3 messenger ribonucleic acids (mRNAs) and proteins that play roles in the ER stress pathway and apoptosis in U87 and T98 human glioblastoma cell lines...
2024: Romanian Journal of Morphology and Embryology
https://read.qxmd.com/read/38527963/reticulon-2-deficiency-results-in-an-autosomal-recessive-distal-motor-neuropathy-with-lower-limb-spasticity
#18
JOURNAL ARTICLE
Reza Maroofian, Payam Sarraf, Thomas J O'Brien, Mona Kamel, Arman Cakar, Nour Elkhateeb, Tracy Lau, Siddaramappa Jagdish Patil, Christopher J Record, Alejandro Horga, Miriam Essid, Laila Selim, Hanene Benrhouma, Thouraya Ben Younes, Giovanni Zifarelli, Alistair T Pagnamenta, Peter Bauer, Mukhran Khundadze, Andrea Mirecki, Sara Mahmoud Kamel, Mohamed A Elmonem, Ehsan Ghayoor Karimiani, Yalda Jamshidi, Amaka C Offiah, Alexander M Rossor, Ilhem Ben Youssef-Turki, Christian A Hübner, Pinki Munot, Mary M Reilly, André E X Brown, Sara Nagy, Henry Houlden
Heterozygous RTN2 variants have been previously identified in a limited cohort of families affected by autosomal dominant spastic paraplegia (SPG12-OMIM:604805) with a variable age of onset. Nevertheless, the definitive validity of SPG12 remains to be confidently confirmed due to scarcity of supporting evidence. In our study, we identified and validated seven novel or ultra-rare homozygous loss-of-function RTN2 variants in 14 individuals from seven consanguineous families with distal hereditary motor neuropathy (dHMN) using exome, genome and Sanger sequencing coupled with deep-phenotyping...
March 25, 2024: Brain
https://read.qxmd.com/read/38527899/molybdenum-and-cadmium-co-induce-necroptosis-through-th1-th2-imbalance-mediated-endoplasmic-reticulum-stress-in-duck-ovaries
#19
JOURNAL ARTICLE
Ting Cui, Xueyan Dai, Huiling Guo, Dianyun Wang, Bingyan Huang, Wenjing Pu, Xuesheng Chu, Caiying Zhang
Cadmium (Cd) and excess molybdenum (Mo) pose serious threats to animal health. Our previous study has determined that Cd and/or Mo exposure can cause ovarian damage of ducks, while the specific mechanism is still obscure. To further investigate the toxic mechanism of Cd and Mo co-exposure in the ovary, forty 8-day-old female ducks were randomly allocated into four groups for 16 weeks, and the doses of Cd and Mo in basic diet per kg were as follows: control group, Mo group (100 mg Mo), Cd group (4 mg Cd), and Mo + Cd group (100 mg Mo + 4 mg Cd)...
August 2024: Journal of Environmental Sciences (China)
https://read.qxmd.com/read/38527700/potential-targets-for-the-treatment-of-mi-grp75-mediated-ca-2-transfer-in-mam
#20
JOURNAL ARTICLE
Chenyan Zhang, Bowen Liu, Jiaxing Sheng, Jia Wang, Weijie Zhu, Chen Xie, Xuan Zhou, Yuxin Zhang, Qinghai Meng, Yu Li
After myocardial infarction (MI), there is a notable disruption in cellular calcium ion homeostasis and mitochondrial function, which is believed to be intricately linked to endoplasmic reticulum (ER) stress. This research endeavors to elucidate the involvement of glucose regulated protein 75 (GRP75) in post-MI calcium ion homeostasis and mitochondrial function. In MI rats, symptoms of myocardial injury were accompanied by an increase in the activation of ER stress. Moreover, in oxygen-glucose deprivation (OGD)-induced cardiomyocytes, it was confirmed that inhibiting ER stress exacerbated intracellular Ca2+ disruption and cell apoptosis...
March 23, 2024: European Journal of Pharmacology
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