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Developmental trauma disorder

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https://www.readbyqxmd.com/read/28193459/epileptiform-activity-and-behavioral-arrests-in-mice-overexpressing-the-calcium-channel-subunit-%C3%AE-2%C3%AE-1
#1
Leonardo C Faria, Feng Gu, Isabel Parada, Ben Barres, Z David Luo, David A Prince
: The alpha2delta-1 subunit (α2δ-1) of voltage-gated calcium channels is a receptor for astrocyte-secreted thrombospondins that promote developmental synaptogenesis.Alpha2delta-1 receptors are upregulated in models of injury-induced peripheral pain and epileptogenic neocortical trauma associated with an enhancement of excitatory synaptic connectivity. These results lead to the hypothesis that overexpression of α2δ-1 alone in neocortex of uninjured transgenic (TG) mice might result in increased excitatory connectivity and consequent cortical hyperexcitability and epileptiform activity...
February 10, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28170306/evaluating-diagnostic-and-statistical-manual-of-mental-disorders-fifth-edition-posttraumatic-stress-disorder-diagnostic-criteria-in-older-children-and-adolescents
#2
Amy J Mikolajewski, Michael S Scheeringa, Carl F Weems
OBJECTIVES: Few studies have assessed how the diagnostic criteria for posttraumatic stress disorder (PTSD) apply to older children and adolescents. With the introduction of a new, developmentally sensitive set of criteria for very young children (age 6 years and younger) in Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5), this raises new questions about the validity of the criteria for older children and adolescents. The current study investigated how diagnostic changes in DSM-5 impact diagnosis rates in 7-18-year olds...
February 7, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28141715/-when-the-prescription-pad-is-not-enough-attention-deficit-hyperactivity-disorder-management-2-0
#3
Jenny Radesky, Arathi Reddy, Naomi Steiner, Marilyn Augustyn
Jose is a 13-year-old boy who presents to his primary care provider after struggling in school for many years. When he was in the first grade, he was diagnosed at a tertiary center with attention-deficit hyperactivity disorder. Multiple medication trials have produced few benefits and many side effects including poor sleep, morbid thoughts, lack of motivation, and, according to his parents, "he seemed like a robot."He comes now for his annual physical in April, and the parents tell you that the school is threatening that he be retained in the seventh grade...
February 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28128430/-the-neural-networks-of-facial-expression
#4
REVIEW
F Gordillo, L Mestas, G Castillo, M A Perez, R M Lopez, J M Arana
INTRODUCTION: Face perception involves a broad network of connections between cortical and subcortical regions for the exchange and synchronization of information using white matter fibers. This precise communication system can be affected by the structures and the pathways that connect them. AIMS: To establish the neural substrate underlying the perception of facial expression and to analyze the different factors involved in modulating the integrity of this neural network, with the aim being to introduce improvements into rehabilitation programs...
February 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28042663/all-our-sons-the-developmental-neurobiology-and-neuroendocrinology-of-boys-at-risk
#5
Allan N Schore
Why are boys at risk? To address this question, I use the perspective of regulation theory to offer a model of the deeper psychoneurobiological mechanisms that underlie the vulnerability of the developing male. The central thesis of this work dictates that significant gender differences are seen between male and female social and emotional functions in the earliest stages of development, and that these result from not only differences in sex hormones and social experiences but also in rates of male and female brain maturation, specifically in the early developing right brain...
January 2017: Infant Mental Health Journal
https://www.readbyqxmd.com/read/28002080/on-the-etiology-of-listening-difficulties-in-noise-despite-clinically-normal-audiograms
#6
Martin Pienkowski
Many people with difficulties following conversations in noisy settings have "clinically normal" audiograms, that is, tone thresholds better than 20 dB HL from 0.1 to 8 kHz. This review summarizes the possible causes of such difficulties, and examines established as well as promising new psychoacoustic and electrophysiologic approaches to differentiate between them. Deficits at the level of the auditory periphery are possible even if thresholds remain around 0 dB HL, and become probable when they reach 10 to 20 dB HL...
December 19, 2016: Ear and Hearing
https://www.readbyqxmd.com/read/27907846/modelling-life-satisfaction-and-adjustment-to-trauma-in-children-exposed-to-ongoing-military-violence-an-exploratory-study-in-palestine
#7
Guido Veronese, Alessandro Pepe, Alaa Jaradah, Feda Al Muranak, Husam Hamdouna
Exposure to war and ongoing political violence increases mental health risks among children, especially in terms of posttraumatic stress disorder (PTSD), and depressive or somatic symptoms. However, an exclusive focus on negative functioning can lead to underestimating the coping abilities and natural potential for adjusting to trauma of war-affected children at different developmental phases. Using structural equation modelling, we tested the extent to which data gathered in a predominantly nonclinical sample of Palestinian children (N=1276) living in refugee camps supported a conceptual model in which the relationship between subjective wellbeing and the effects of trauma is mainly top-down in direction...
January 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/27895485/adhd-and-present-hedonism-time-perspective-as-a-potential-diagnostic-and-therapeutic-tool
#8
REVIEW
S Weissenberger, M Klicperova-Baker, P Zimbardo, K Schonova, D Akotia, J Kostal, M Goetz, J Raboch, R Ptacek
The article draws primarily from the behavioral findings (mainly psychiatric and psychological observations) and points out the important relationships between attention-deficit/hyperactivity disorder (ADHD) symptoms and time orientation. Specifically, the authors argue that there is a significant overlap between the symptoms of ADHD and Present Hedonism. Present Hedonism is defined by Zimbardo's time perspective theory and assessed by Zimbardo Time Perspective Inventory. Developmental data on Present Hedonism of males and females in the Czech population sample (N=2201) are also presented...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27863803/research-domain-criteria-and-the-study-of-trauma-in-children-implications-for-assessment-and-treatment-research
#9
REVIEW
Carla Smith Stover, Brooks Keeshin
By definition, the Diagnostic and Statistical Manual (DSM) diagnosis of posttraumatic stress disorder (PTSD) requires exposure to a traumatic event. Yet, the DSM diagnostic requirements for children and adolescents for PTSD may fail to capture traumatized youth with significant distress and functional impairment. Many important studies have utilized PTSD diagnosis as a mechanism for grouping individuals for comparative studies examining brain functioning, neuroendocrinology, genetics, attachment, and cognition; however, focusing only on those with the diagnosis of PTSD can miss the spectrum of symptoms and difficulties that impact children who experience trauma and subsequent impairment...
November 9, 2016: Clinical Psychology Review
https://www.readbyqxmd.com/read/27844058/western-high-fat-diet-consumption-during-adolescence-increases-susceptibility-to-traumatic-stress-while-selectively-disrupting-hippocampal-and-ventricular-volumes
#10
Priya Kalyan-Masih, Julio David Vega-Torres, Christina Miles, Elizabeth Haddad, Sabrina Rainsbury, Mohsen Baghchechi, Andre Obenaus, Johnny D Figueroa
Psychological trauma and obesity co-occur frequently and have been identified as major risk factors for psychiatric disorders. Surprisingly, preclinical studies examining how obesity disrupts the ability of the brain to cope with psychological trauma are lacking. The objective of this study was to determine whether an obesogenic Western-like high-fat diet (WD) predisposes rats to post-traumatic stress responsivity. Adolescent Lewis rats (postnatal day 28) were fed ad libitum for 8 weeks with either the experimental WD diet (41...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27830573/developmental-contributors-to-trauma-response-the-importance-of-sensitive-periods-early-environment-and-sex-differences
#11
Jennifer S Stevens, Sanne J H van Rooij, Tanja Jovanovic
This review considers early factors that interact with development to contribute to later trauma responses, including developmental sensitive periods, the effects of early environment, and the emergence of sex differences. We also describe development of neural substrates that have been associated with posttraumatic stress disorder and specifically focus on fear behavior and circuitry. Emerging evidence suggests that there may be developmental shifts around age 10 in these underlying circuits that may contribute to vulnerability...
November 10, 2016: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/27799420/public-health-implications-and-risks-for-children-and-families-resettled-after-exposure-to-armed-conflict-and-displacement
#12
Rachel Calam
Early adverse experiences can precede long-term negative effects on physical health. Children experiencing armed conflict, flight and displacement, and refugee life may be at enhanced risk. Recent psychobiological models integrating knowledge about perinatal and childhood stress with susceptibility to chronic illnesses in later life make clear the pressing need for protective provision for war-affected children, who experience multiple traumas and continuing stressors. There is increasing recognition of the mechanisms linking physical and mental health with adult diseases seen as developmental disorders with origins early in life...
October 30, 2016: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/27752989/femoral-morphology-in-the-dysplastic-hip-three-dimensional-characterizations-with-ct
#13
Joel Wells, Jeffrey J Nepple, Karla Crook, James R Ross, Asheesh Bedi, Perry Schoenecker, John C Clohisy
BACKGROUND: Hip dysplasia represents a spectrum of complex deformities on both sides of the joint. Although many studies have described the acetabular side of the deformity, to our knowledge, little is known about the three-dimensional (3-D) head and neck offset differences of the femora of dysplastic hips. A thorough knowledge of proximal femoral anatomy is important to prevent potential impingement and improve results after acetabular reorientation. QUESTIONS/PURPOSES: (1) Are there common proximal femoral characteristics in patients with symptomatic hip dysplasia undergoing periacetabular osteotomy (PAO)? (2) Where is the location of maximal femoral head and neck offset deformity in hip dysplasia? (3) Do certain subgroups of dysplastic hips more commonly have cam-type femoral morphology? (4) Is there a relationship between hip ROM as well as impingement testing and 3-D head and neck offset deformity? METHODS: Using our hip preservation database, 153 hips (148 patients) underwent PAO from October 2013 to July 2015...
October 17, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27750253/toward-a-theory-of-stuttering
#14
Anthony R Mawson, Nola T Radford, Binu Jacob
Stuttering affects about 1% of the general population and from 8 to 11% of children. The onset of persistent developmental stuttering (PDS) typically occurs between 2 and 4 years of age. The etiology of stuttering is unknown and a unifying hypothesis is lacking. Clues to the pathogenesis of stuttering include the following observations: PDS is associated with adverse perinatal outcomes and birth-associated trauma; stuttering can recur or develop in adulthood following traumatic events such as brain injury and stroke; PDS is associated with structural and functional abnormalities in the brain associated with speech and language; and stuttering resolves spontaneously in a high percentage of affected children...
2016: European Neurology
https://www.readbyqxmd.com/read/27744270/mental-health-problems-among-children-and-adolescents-experiencing-two-major-earthquakes-in-remote-mountainous-regions-a-longitudinal-study
#15
Wanjie Tang, Jingdong Zhao, Yi Lu, Tingting Yan, Lijuan Wang, Jun Zhang, Jiuping Xu
OBJECTIVE: Millions of children were exposed to major earthquake in China, with serious psychological and developmental consequences. To obtain accurate rate of post-disaster related disorder and identify predictors may help inform post-disaster rescue and rehabilitation efforts. The present longitudinal study explored correlations of demographic and socioeconomic characteristics of juvenile survivors of the Ya'an and Wenchuan earthquakes in China with their trajectories of post-disaster related disorder...
January 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27728852/is-developmental-timing-of-trauma-exposure-associated-with-depressive-and-post-traumatic-stress-disorder-symptoms-in-adulthood
#16
Erin C Dunn, Kristen Nishimi, Abigail Powers, Bekh Bradley
BACKGROUND: Trauma exposure is a known risk factor for psychopathology. However, the impact of the developmental timing of exposure remains unclear. This study examined the effect of age at first trauma exposure on levels of adult depressive and posttraumatic stress disorder (PTSD) symptoms. METHODS: Lifetime trauma exposure (including age at first exposure and frequency), current psychiatric symptoms, and sociodemographic information were collected during interviews with adults participating in a study at a public urban hospital in Atlanta, GA...
January 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27720483/the-calcium-channel-subunit-alpha2delta2-suppresses-axon-regeneration-in-the-adult-cns
#17
Andrea Tedeschi, Sebastian Dupraz, Claudia J Laskowski, Jia Xue, Thomas Ulas, Marc Beyer, Joachim L Schultze, Frank Bradke
Injuries to the adult CNS often result in permanent disabilities because neurons lose the ability to regenerate their axon during development. Here, whole transcriptome sequencing and bioinformatics analysis followed by gain- and loss-of-function experiments identified Cacna2d2, the gene encoding the Alpha2delta2 subunit of voltage-gated calcium channels (VGCCs), as a developmental switch that limits axon growth and regeneration. Cacna2d2 gene deletion or silencing promoted axon growth in vitro. In vivo, Alpha2delta2 pharmacological blockade through Pregabalin (PGB) administration enhanced axon regeneration in adult mice after spinal cord injury (SCI)...
October 19, 2016: Neuron
https://www.readbyqxmd.com/read/27623149/cortisol-heart-rate-and-blood-pressure-as-early-markers-of-ptsd-risk-a-systematic-review-and-meta-analysis
#18
REVIEW
Matthew C Morris, Natalie Hellman, James L Abelson, Uma Rao
Individuals with posttraumatic stress disorder (PTSD) typically exhibit altered hypothalamic-pituitary-adrenal (HPA) function and sympathetic nervous system (SNS) activity. The goals of this study were to determine whether HPA and SNS alterations in the immediate aftermath of trauma predict subsequent PTSD symptom development and whether inconsistencies observed between studies can be explained by key demographic and methodological factors. This work informs secondary prevention of PTSD by identifying subgroups of trauma survivors at risk for PTSD...
November 2016: Clinical Psychology Review
https://www.readbyqxmd.com/read/27615053/phenotype-of-7q11-23-duplication-a-family-clinical-series
#19
Beth A Earhart, Marian E Williams, Irina Zamora, Linda Marie Randolph, Jodie K Votava-Smith, Stephanie N Marcy
Duplication 7q11.23 syndrome is the reciprocal of Williams-Beuren deletion syndrome. Studies have reported a recognizable phenotype, including autism, intellectual disability, speech, and language delay, social anxiety, and behavioral difficulties in these individuals. Previous studies revealed a variety of craniofacial abnormalities, brain malformations, and cardiac abnormalities, including aortic dilation. This patient series evaluates five family members aged 2 months to 35 years, all with confirmed 7q11...
January 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/27604117/-early-life-stress-and-vulnerability-for-disease-in-later-life
#20
Sonja Entringer, Claudia Buss, Christine Heim
BACKGROUND: The rapidly growing research field of developmental programming of health and disease risk investigates the early life origins of individual vulnerability for common, complex disorders that confer a major burden of disease. OBJECTIVES: The present article introduces the concept of developmental programming of disease vulnerability and summarizes studies on the mental and physical health consequences of exposure to childhood trauma and prenatal stress...
October 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
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