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https://www.readbyqxmd.com/read/28214606/payload-release-by-liposome-burst-thermal-collapse-of-microgels-induces-satellite-destruction
#1
Alexander Yaroslavov, Irina Panova, Andrey Sybachin, Vasiliy Spiridonov, Alexander Zezin, Olga Mergel, Arjan Gelissen, Rahul Tiwari, Felix Plamper, Walter Richtering, Fredric Menger
No abstract text is available yet for this article.
February 15, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28213945/optimization-of-initial-propofol-bolus-dose-for-eeg-narcotrend-index-guided-transition-from-sevoflurane-induction-to-intravenous-anesthesia-in-children
#2
Nils Dennhardt, Dietmar Boethig, Christiane Beck, Sebastian Heiderich, Martin Boehne, Andreas Leffler, Barbara Schultz, Robert Sümpelmann
BACKGROUND: Sevoflurane induction followed by intravenous anesthesia is a widely used technique to combine the benefits of an easier and less traumatic venipuncture after sevoflurane inhalation with a recovery with less agitation, nausea, and vomiting after total intravenous anesthesia (TIVA). Combination of two different anesthetics may lead to unwanted burst suppression in the electroencephalogram (EEG) during the transition phase. OBJECTIVE: The objective of this prospective clinical observational study was to identify the optimal initial propofol bolus dose for a smooth transition from sevoflurane induction to TIVA using the EEG Narcotrend Index (NI)...
February 18, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28213155/high-frequency-stimulation-of-afferent-fibers-generates-asynchronous-firing-in-the-downstream-neurons-in-hippocampus-through-partial-block-of-axonal-conduction
#3
Zhouyan Feng, Zhaoxiang Wang, Zheshan Guo, Wenjie Zhou, Ziyan Cai, Dominique M Durand
Deep brain stimulation (DBS) is effective for treating neurological disorders in clinic. However, the therapeutic mechanisms of high-frequency stimulation (HFS) of DBS have not yet been elucidated. Previous studies have suggested that HFS-induced changes in axon conduction could have important contributions to the DBS effects and desiderate further studies. To investigate the effects of prolonged HFS of afferent axons on the firing of downstream neurons, HFS trains of 100 and 200 Hz were applied on the Schaffer collaterals of the hippocampal CA1 region in anaesthetized rats...
February 14, 2017: Brain Research
https://www.readbyqxmd.com/read/28213104/isolation-and-characterization-of-a-virulent-bacteriophage-infecting-acinetobacter-johnsonii-from-activated-sludge
#4
Niansi Fan, Rong Qi, Min Yang
A double-stranded DNA phage named AJO1, infecting Acinetobacter johnsonii, which plays an important role in wastewater treatment, was isolated from activated sludge in a full-scale municipal wastewater treatment plant. Based on morphological taxonomy, AJO1, with an icosahedral head 55 ± 2 nm in diameter and a non-contractile tail 8 ± 2 nm in length, was classified as a member of the Podoviridae family. Bacterial infection characteristics were as follows: no polyvalent infectivity, optimal multiplicity of infection of 10(-2); eclipse and burst size of 30 min and 51...
February 14, 2017: Research in Microbiology
https://www.readbyqxmd.com/read/28211917/concentration-dependent-oligomerization-of-an-alpha-helical-antifreeze-polypeptide-makes-it-hyperactive
#5
Sheikh Mahatabuddin, Yuichi Hanada, Yoshiyuki Nishimiya, Ai Miura, Hidemasa Kondo, Peter L Davies, Sakae Tsuda
A supersoluble 40-residue type I antifreeze protein (AFP) was discovered in a righteye flounder, the barfin plaice (bp). Unlike all other AFPs characterized to date, bpAFP transitions from moderately-active to hyperactive with increasing concentration. At sub-mM concentrations, bpAFP bound to pyramidal planes of ice to shape it into a bi-pyramidal hexagonal trapezohedron, similarly to the other moderately-active AFPs. At mM concentrations, bpAFP uniquely underwent further binding to the whole ice crystal surface including the basal planes...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28211817/post-stroke-acquired-amusia-a-comparison-between-right-and-left-brain-hemispheric-damages
#6
Zahra Jafari, Mahdiye Esmaili, Ahmad Delbari, Masoud Mehrpour, Majid H Mohajerani
BACKGROUND: Although extensive research has been published about the emotional consequences of stroke, most studies have focused on emotional words, speech prosody, voices, or facial expressions. The emotional processing of musical excerpts following stroke has been relatively unexplored. OBJECTIVE: The present study was conducted to investigate the effects of chronic stroke on the recognition of basic emotions in music. METHODS: Seventy persons, including 25 normal controls (NC), 25 persons with right brain damage (RBD) from stroke, and 20 persons with left brain damage (LBD) from stroke between the ages of 31-71 years were studied...
February 15, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28211679/site-directed-immobilization-of-bmp-2-two-approaches-for-the-production-of-innovative-osteoinductive-scaffolds
#7
Barbara Tabisz, Werner Schmitz, Michael Schmitz, Tessa Luehmann, Eva Heusler, Jens-Christoph Rybak, Lorenz Meinel, Juliane E Fiebig, Thomas D Mueller, Joachim Nickel
The regenerative potential of bone is strongly impaired in pathological conditions, such as nonunion fractures. To support bone regeneration various scaffolds have been developed in the past, which have been functionalized with osteogenic growth factors such as bone morphogenetic proteins (BMPs). However, most of them required supra-physiological levels of these proteins leading to burst releases, thereby causing severe side effects. Site-specific, covalent coupling of BMP2 to implant materials might be an optimal strategy in order to overcome these problems...
February 17, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28211120/the-effect-of-sevoflurane-on-electrocorticographic-spike-activity-in-pediatric-patients-with-epilepsy
#8
Shigekazu Tanaka, Yutaka Oda, Masayoshi Ryokai, Takehiro Uda, Noritsugu Kunihiro, Ichiro Kuki, Ryu Okutani
BACKGROUND: Electrocorticogram (ECoG) spike activity is enhanced under general anesthesia with 1.5 minimum alveolar concentration (MAC) sevoflurane compared with lower concentrations in adult patients with epilepsy. However, the effect of concentration of sevoflurane on ECoG in children with epilepsy is less known. AIMS: The primary endpoint was to investigate the effects of sevoflurane on ECoG spike activity in pediatric patients undergoing epilepsy surgery. The secondary endpoint was to examine its effects on baseline ECoG including burst suppression...
February 17, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28210968/study-on-critical-sized-ultra-high-molecular-weight-polyethylene-wear-particles-loaded-with-alendronate-sodium-in-vitro-release-and-cell-response
#9
Yumei Liu, Feng Shi, Kemeng Gong, Yang Liu, Wei Zhi, Jie Weng, Shuxin Qu
The aim of this study was to investigate the in vitro release and the effect of RAW 264.7 macrophages of critical-sized wear particles of ultra-high molecular weight polyethylene (UHMWPE) loaded with alendronate sodium (ALN), one of the most effective drugs to treat osteoporosis in clinic. The critical-sized UHMWPE-ALN 0.5 wt.% wear particles were prepared by vacuum gradient filtration combined with Pluronic F-68. In vitro release of ALN from critical-sized UHMWPE-ALN wear particles was investigated in phosphate buffered saline (PBS) at 37 °C with a shaker...
April 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28210967/core-shell-drug-carrier-from-folate-conjugated-chitosan-obtained-from-prawn-shell-for-targeted-doxorubicin-delivery
#10
Md Sazedul Islam, Papia Haque, Taslim U Rashid, M Nuruzzaman Khan, Abul K Mallik, M Nazrul I Khan, Mala Khan, Mohammed Mizanur Rahman
A multifunctional drug carrier with dual targeting (magnetic and folate-receptor) and pH sensitive core-shell hybrid nanomaterial has been developed to carry an anticancer drug doxorubicin.Superparamagnetic iron oxide nanoparticles (IONPs) were used as core of the carrier and cross-linked folate conjugated chitosan (FA-CS) was acted as shell in which doxorubicin was physically entrapped. Transmission electron microscopy (TEM) analysis confirmed the average particle size of IONPs and FA-CS coated IONPs 8.2 and 15...
April 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28210396/multivesicular-emulsion-ceramide-containing-moisturizers-an-evaluation-of-their-role-in-the-management-of-common-skin-disorders
#11
REVIEW
Joshua A Zeichner, James Q Del Rosso
Proper stratum corneum function plays a pivotal role in maintenance of skin health, and improper function leads to skin disease. The stratum corneum is comprised of corneocytes surrounded by intercelluar lipids including ceramides, free fatty acids, and cholesterol. Ceramide predominant moisturizers have become a mainstay of treatment of skin disease. New technologies for delivery of ceramides include multivesicular emulsions, which deposit ceramides in a timerelease manner for a continuous rather than burst effect...
December 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28209137/transcriptional-analysis-of-defense-mechanisms-in-upland-tetraploid-switchgrass-to-greenbugs
#12
Teresa Donze-Reiner, Nathan A Palmer, Erin D Scully, Travis J Prochaska, Kyle G Koch, Tiffany Heng-Moss, Jeffrey D Bradshaw, Paul Twigg, Keenan Amundsen, Scott E Sattler, Gautam Sarath
BACKGROUND: Aphid infestation of switchgrass (Panicum virgatum) has the potential to reduce yields and biomass quality. Although switchgrass-greenbug (Schizaphis graminum; GB) interactions have been studied at the whole plant level, little information is available on plant defense responses at the molecular level. RESULTS: The global transcriptomic response of switchgrass cv Summer to GB was monitored by RNA-Seq in infested and control (uninfested) plants harvested at 5, 10, and 15 days after infestation (DAI)...
February 16, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28209001/comparative-evaluation-of-fluoride-releasing-ability-of-various-restorative-materials-after-the-application-of-surface-coating-agents-an-in-vitro-study
#13
Gvs Kishore, A J Sai-Sankar, Mjs Pratap-Gowd, M Sridhar, Kakarla Pranitha, V S Sai-Krishna
INTRODUCTION: Fluoride plays a key role in prevention of dental caries and is also an essential element for oral health promotion both in children and adults. AIM: The aim of the present study was to evaluate the effect of surface coating (petroleum jelly, G-Coat Plus) on the fluoride releasing property of conventional Glass Ionomer Cement (GIC) and Zirconomer. MATERIALS AND METHODS: A total of 30 disk shaped brass mold specimens (6±0.1mm in diameter and 2±0...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208062/nano-suspension-coating-as-a-technique-to-modulate-the-drug-release-from-controlled-porosity-osmotic-pumps-for-a-soluble-agent
#14
Leila Azharshekoufeh Bahari, Yousef Javadzadeh, Mohammad Barzegar Jalali, Peyvand Johari, Ali Nokhodchi, Javad Shokri
In controlled porosity osmotic pumps (CPOP), usually finding a single solvent with a capability to dissolve both film former (hydrophobic) and pore former (hydrophilic) is extremely challenging. Therefore, the aim of the present investigation was to tackle the issue associated with controlled porosity osmotic pump (CPOP) system using nano-suspension coating method. In the present study 4-Amino pyridine was used as a highly water soluble drug. In this method, a hydrophilic pore former (sucrose or mannitol) in nano range was suspended in polymeric coating solution using ball-mill...
February 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28206999/early-eeg-power-predicts-mri-injury-in-infants-with-hypoxic-ischemic-encephalopathy
#15
S V Jain, J M Zempel, P Srinivasakumar, M Wallendorf, A Mathur
OBJECTIVE: Early identification of infants with hypoxic-ischemic encephalopathy who have adverse outcomes despite neuroprotection with therapeutic hypothermia (TH) is urgently needed. Recent studies have found limited value of amplitude integrated EEG (aEEG) for predicting short-term outcomes in this population. Other quantitative electroencephalography (EEG) variables reflecting EEG amplitude, such as EEG power, could provide early stratification of a high-risk cohort in this population...
February 16, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28206685/claustrum-of-the-short-tailed-fruit-bat-carollia-perspicillata-alignment-of-cellular-orientation-and-functional-connectivity
#16
Rena Orman, Richard Kollmar, Mark Stewart
The claustrum is a gray-matter structure that underlies neocortex and reciprocates connections with cortical and subcortical targets. In lower mammals, the claustrum is directly adjacent to neocortex, making the definition of claustral boundaries challenging. Latexin, an endogenous inhibitor of metallocarboxypeptidases, localizes to claustral cells, enabling a clear delineation of claustrum. Given its proportionately large claustrum, we hypothesized that the short-tailed fruit bat, Carollia perspicillata, can be a useful model for claustral structure-function relations...
April 15, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28205011/neural-control-of-blood-pressure-in-women-differences-according-to-age
#17
Ana B Peinado, Ronee E Harvey, Emma C Hart, Nisha Charkoudian, Timothy B Curry, Wayne T Nicholson, B Gunnar Wallin, Michael J Joyner, Jill N Barnes
PURPOSE: The blood pressure "error signal" represents the difference between an individual's mean diastolic blood pressure and the diastolic blood pressure at which 50% of cardiac cycles are associated with a muscle sympathetic nerve activity burst (the "T50"). In this study we evaluated whether T50 and the error signal related to the extent of change in blood pressure during autonomic blockade in young and older women, to study potential differences in sympathetic neural mechanisms regulating blood pressure before and after menopause...
February 16, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28203145/bidirectional-hebbian-plasticity-induced-by-low-frequency-stimulation-in-basal-dendrites-of-rat-barrel-cortex-layer-5-pyramidal-neurons
#18
Andrea Díez-García, Natali Barros-Zulaica, Ángel Núñez, Washington Buño, David Fernández de Sevilla
According to Hebb's original hypothesis (Hebb, 1949), synapses are reinforced when presynaptic activity triggers postsynaptic firing, resulting in long-term potentiation (LTP) of synaptic efficacy. Long-term depression (LTD) is a use-dependent decrease in synaptic strength that is thought to be due to synaptic input causing a weak postsynaptic effect. Although the mechanisms that mediate long-term synaptic plasticity have been investigated for at least three decades not all question have as yet been answered...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28202907/calpain-1-deletion-impairs-mglur-dependent-ltd-and-fear-memory-extinction
#19
Guoqi Zhu, Victor Briz, Jeff Seinfeld, Yan Liu, Xiaoning Bi, Michel Baudry
Recent studies indicate that calpain-1 is required for the induction of long-term potentiation (LTP) elicited by theta-burst stimulation in field CA1 of hippocampus. Here we determined the contribution of calpain-1 in another type of synaptic plasticity, the long-term depression (LTD) elicited by activation of type-I metabotropic glutamate receptors (mGluR-LTD). mGluR-LTD was associated with calpain-1 activation following T-type calcium channel opening, and resulted in the truncation of a regulatory subunit of PP2A, B56α...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28202586/waveform-sensitivity-of-electroreceptors-in-the-pulse-weakly-electric-fish-gymnotus-omarorum
#20
Alejo Rodríguez-Cattaneo, Pedro A Aguilera, Angel A Caputi
As in most sensory systems electrosensory images in weakly electric fish are encoded in two parallel pathways, fast and slow. From the work on wave type electric fish these pathways are thought to encode the time and amplitude of electrosensory signals respectively. This article focuses on the primary afferents giving origin to the slow path of the pulse type weakly electric fish Gymnotus omarorum We found that burst duration coders respond with a high-frequency train of spikes to each electric organ discharge...
February 15, 2017: Journal of Experimental Biology
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