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https://www.readbyqxmd.com/read/28431308/hyperexcitability-of-inferior-colliculus-and-acoustic-startle-reflex-with-age-related-hearing-loss
#1
Binbin Xiong, Ana'am Alkharabsheh, Senthilvelan Manohar, Guang-Di Chen, Ning Yu, Xiaoming Zhao, Richard Salvi, Wei Sun
Chronic tinnitus and hyperacusis often develop with age-related hearing loss presumably due to aberrant neural activity in the central auditory system (CAS) induced by cochlear pathologies. However, the full spectrum of physiological changes that occur in the CAS as a result age-related hearing loss are still poorly understood. To address this issue, neurophysiological measures were obtained from the cochlea and the inferior colliculus (IC) of 2, 6 and 12 month old C57BL/6J mice, a mouse model for early age-related hearing loss...
March 27, 2017: Hearing Research
https://www.readbyqxmd.com/read/28431136/c1-lateral-mass-displacement-and-transverse-atlantal-ligament-failure-in-jefferson-s-fracture-a-biomechanical-study-of-the-rule-of-spence
#2
Rafeek O Woods, Serkan Inceoglu, Yusuf T Akpolat, Wayne K Cheng, Brice Jabo, Olumide Danisa
BACKGROUND: Jefferson's fracture, first described in 1927, represents a bursting fracture of the C1 ring with lateral displacement of the lateral masses. It has been determined that if the total lateral mass displacement (LMD) exceeds 6.9 mm, there is high likelihood of transverse atlantal ligament (TAL) rupture, and if LMD is less than 5.7 mm TAL injury is unlikely. Several recent radiographic studies have questioned the accuracy and validity of the "rule of Spence" and it lacks biomechanical support...
April 20, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28428769/individualized-repetitive-transcranial-magnetic-stimulation-treatment-in-chronic-tinnitus
#3
Peter M Kreuzer, Timm B Poeppl, Rainer Rupprecht, Veronika Vielsmeier, Astrid Lehner, Berthold Langguth, Martin Schecklmann
BACKGROUND: Prefrontal and temporo-parietal repetitive transcranial magnetic stimulation (rTMS) in patients suffering from chronic tinnitus have shown significant but only moderate effectiveness with high interindividual variability in treatment response. This open-label pilot study was designed to examine the general feasibility of an individualized fronto-temporal rTMS protocol and to explore what criteria are needed for a more detailed evaluation in randomized clinical studies. METHODS: During the first session of a 2-week rTMS protocol, we applied different rTMS protocols to the left and right temporo-parietal and dorsolateral prefrontal cortex (DLPFC) in 25 tinnitus patients...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28428756/neck-circumference-is-associated-with-muscle-sympathetic-nerve-activity-in-overweight-and-obese-men-but-not-women
#4
Nora E Straznicky, Mariee T Grima, Carolina I Sari, Nina Eikelis, Paul J Nestel, John B Dixon, Gavin W Lambert, Markus P Schlaich, Sarah E Phillips, Elisabeth A Lambert
Background: Neck circumference (NC) is a predictor of cardiometabolic risk. The objective of this study was to explore the relationship of NC to muscle sympathetic nerve activity (MSNA) within an overweight and obese population. Methods: The study design was a retrospective cross-sectional analysis. Un-medicated persons (72 men, 53 postmenopausal women) aged 56 ± 1 years (mean ± SEM) with body mass index (BMI) 32.8 ± 0.4 kg/m(2), were studied. NC was measured together with traditional anthropometric measures, supine blood pressure, fasting blood lipids, insulin, and glucose...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28428563/a-sublethal-dose-of-a-neonicotinoid-insecticide-disrupts-visual-processing-and-collision-avoidance-behaviour-in-locusta-migratoria
#5
Rachel H Parkinson, Jacelyn M Little, John R Gray
Neonicotinoids are known to affect insect navigation and vision, however the mechanisms of these effects are not fully understood. A visual motion sensitive neuron in the locust, the Descending Contralateral Movement Detector (DCMD), integrates visual information and is involved in eliciting escape behaviours. The DCMD receives coded input from the compound eyes and monosynaptically excites motorneurons involved in flight and jumping. We show that imidacloprid (IMD) impairs neural responses to visual stimuli at sublethal concentrations, and these effects are sustained two and twenty-four hours after treatment...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28426849/effect-of-adalimumab-on-visual-functioning-in-patients-with-noninfectious-intermediate-uveitis-posterior-uveitis-and-panuveitis-in-the-visual-1-and-visual-2-trials
#6
John Sheppard, Avani Joshi, Keith A Betts, Stacie Hudgens, Samir Tari, Naijun Chen, Martha Skup, Andrew D Dick
Importance: Adalimumab was recently approved for the treatment of noninfectious intermediate uveitis, posterior uveitis, and panuveitis. Objective: To assess the effect of adalimumab on the visual functioning and quality of life in patients with corticosteroid-dependent noninfectious intermediate uveitis, posterior uveitis, and panuveitis. Design: A post hoc analysis of clinical trials of adults with active (VISUAL-1) and inactive (VISUAL-2) noninfectious intermediate uveitis, posterior uveitis, and panuveitis was conducted in the United States, Canada, Europe, Israel, Australia, Latin America, and Japan...
April 20, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28425869/development-of-a-chitosan-based-nanoparticle-formulation-for-ophthalmic-delivery-of-honokiol
#7
Feng Deng, Wenjing Hu, Huali Chen, Yalan Tang, Liangke Zhang
In this study, honokiol-loaded chitosan/sulfobutylether-β-cyclodextrin nanoparticles (HK-CS-NPs) were prepared for ophthalmic drug delivery systems. An inclusion complex of honokiol and sulfobutylether-β-cyclodextrin was used to generate large amounts of insoluble honokiol to be incorporated into chitosan nanoparticles, which were prepared through ionotropic gelation. HK-CS-NPs featured a spherical surface with a narrow size distribution of polydispersity index less than 0.250, a mean size range of 373-523 nm, a positive surface charge of +19...
April 19, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28424941/isolation-and-complete-genome-sequence-of-a-novel-pseudoalteromonas-phage-ph357-from-the-yangtze-river-estuary
#8
Zheng Gong, Min Wang, Qingwei Yang, Zhongshi Li, Jun Xia, Yu Gao, Yong Jiang, Xue Meng, Zhaoyang Liu, Ding Yang, Fangfei Zhang, Hongbing Shao, Duobing Wang
Phage PH357, a novel lytic Pseudoalteromonas lipolytica phage belonging to the Myoviridae family was isolated from the Yangtze River estuary. The microbiological characterization demonstrated that phage PH357 is stable from -20 to 60 °C and the optimal pH 7. The one-step growth curve showed a latent period of 20 min, a rise period of 20 min, and the average burst size was about 85 virions per cell. Complete genome of phage PH357 was determined. Genome of phage PH357 consisted of a linear, double-stranded 136,203 bp DNA molecule with 34...
April 20, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28424939/characterization-and-complete-genome-sequence-of-a-novel-siphoviridae-bacteriophage-bs5
#9
Xue Meng, Min Wang, Siyuan You, Duobing Wang, Yan Li, Zhaoyang Liu, Yu Gao, Lu Liu, Yaoyuan Zhang, Zhenghao Yan, Chunyan Liu, Yong Jiang, Hongbing Shao
A novel Siphoviridae family Phage BS5, which infects Pseudoalteromonas atlantica, was isolated from the surface waters of the Yellow Sea. Morphological study by transmission electron microscopy revealed that the novel phage belongs to Siphoviridae. The complete genome sequence of PBS5 contained a linear, double-strand 39949-bp DNA molecule with a G + C content of 40.6% and 65 putative open reading frames. Twelve conserved domains were detected by BLASTP in NCBI, and of these the functions of 5 were known...
April 20, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28424938/characterization-and-genome-sequence-of-marine-alteromonas-gracilis-phage-pb15-isolated-from-the-yellow-sea-china
#10
Yu Gao, Qian Liu, Min Wang, Guihua Zhao, Yong Jiang, Gill Malin, Zheng Gong, Xue Meng, Zhaoyang Liu, Tongtong Lin, Yutong Li, Hongbing Shao
A novel marine Alteromonas gracilis siphovirus, phage PB15, was isolated from the surface water of the Yellow Sea in August 2015. It has a head diameter of 58 ± 5 nm head and a contractile tail approximately 105 ± 10 nm in length, and overall, the morphology suggests that PB15 belongs to the family Siphoviridae. PB15 phage is stable at over the temperature range 0-60 °C. The best MOI of these phage was 0.1, and infectivity decreased above 60 °C. The results suggest that phage is stable at pH value ranging between 3...
April 20, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28424550/doxorubicin-loaded-poly-lactic-co-glycolic-acid-nanoparticles-coated-with-chitosan-alginate-by-layer-by-layer-technology-for-antitumor-applications
#11
Fujuan Chai, Linlin Sun, Xinyi He, Jieli Li, Yuanfen Liu, Fei Xiong, Liang Ge, Thomas J Webster, Chunli Zheng
Natural polyelectrolyte multilayers of chitosan (CHI) and alginate (ALG) were alternately deposited on doxorubicin (DOX)-loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) with layer by layer self-assembly to control drug release for antitumor activity. Numerous factors which influenced the multilayer growth on nano-colloidal particles were studied: polyelectrolyte concentration, NaCl concentration and temperature. Then the growth regime of the CHI/ALG multilayers was elucidated. The coated NPs were characterized by transmission electron microscopy, atomic force microscopy, X-ray diffraction and a zeta potential analyzer...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28424536/rifapentine-linezolid-loaded-plga-microspheres-for-interventional-therapy-of-cavitary-pulmonary-tuberculosis-preparation-and-in-vitro-characterization
#12
Jieyun Huang, Zhi Chen, Ying Li, Li Li, Guangyu Zhang
In this study, we aimed to design controlled-release microspheres for the treatment of cavitary pulmonary tuberculosis (TB) for solving the issues of poor drug delivery and short duration maintained at effective drug concentration during bronchoscopic interventional therapy. We fabricated rifapentine-linezolid-loaded poly(lactic acid-co-glycolic acid) microspheres (RLPMs) using the oil-in-water emulsion solvent evaporation method and assessed their in vitro release as well as the bronchial mucosal retention characteristics...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28423344/prolonged-dark-period-modulates-the-oxidative-burst-and-enzymatic-antioxidant-systems-in-the-leaves-of-salicylic-acid-treated-tomato
#13
Péter Poór, Zoltán Takács, Krisztina Bela, Zalán Czékus, Gabriella Szalai, Irma Tari
Salicylic acid (SA) is an important plant growth regulator playing a role in the hypersensitive reaction (HR) and the induction of systemic acquired resistance. Since the SA-mediated signalling pathways and the formation of reactive oxygen species (ROS) are light-dependent, the time- and concentration-specific induction of oxidative stress was investigated in leaves of tomato plants kept under light and dark conditions after treatments with 0.1mM and 1mM SA. The application of exogenous SA induced early superoxide- and H2O2 production in the leaves, which was different in the absence or presence of light and showed time- and concentration-dependent changes...
March 23, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28422989/the-lack-of-btk-does-not-impair-monocytes-and-polymorphonuclear-cells-functions-in-x-linked-agammaglobulinemia-under-treatment-with-intravenous-immunoglobulin-replacement
#14
Filomena Monica Cavaliere, Alessandro Prezzo, Caterina Bilotta, Metello Iacobini, Isabella Quinti
The lack of BTK in X-linked agammaglobulinemia (XLA) patients does not affect monocytes and polymorphonuclear cells (PMN) phenotype and functions. In this study, we show that XLA patients had an increased frequency of the intermediate monocytes subset and that BTK-deficient monocytes and PMN had a normal expression of receptors involved in the activation and cellular responses. We demonstrate that BTK is not required for migration, phagocytosis and the production of reactive oxygen species (ROS) following engagement of FC gamma receptors (FcγR)...
2017: PloS One
https://www.readbyqxmd.com/read/28421137/the-effect-of-temperature-on-development-and-behaviour-of-relict-leopard-frog-tadpoles
#15
Jeffrey A Goldstein, Karin von Seckendorr Hoff, Stanley D Hillyard
Relict leopard frog (Rana [Lithobates] onca) tadpoles were obtained shortly after hatching at Gosner stage 25 and raised in aquaria maintained at 15, 20, 25, 30 and 35°C. Development was arrested in the 15°C group, and survivorship declined to 64% after 191 days. However, 80% of the surviving larvae remained alive after the temperature was increased to 25°C. Of these, 96% reached metamorphosis. Survivorship of the 20, 25 and 30°C acclimation groups was 82, 94 and 66%, respectively, whereas none survived at 35°C...
2017: Conservation Physiology
https://www.readbyqxmd.com/read/28420761/in-situ-measurements-of-tensile-forces-in-the-tibialis-anterior-tendon-of-the-rat-in-concentric-isometric-and-resisted-co-contractions
#16
Martin Schmoll, Ewald Unger, Hazel Sutherland, Michael Haller, Manfred Bijak, Hermann Lanmüller, Jonathan C Jarvis
Tensile-force transmitted by the tibialis anterior (TA) tendon of 11 anesthetized adult male Wistar rats (body-mass: 360.6 ± 66.3 g) was measured in-situ within the intact biomechanical system of the hind-limb using a novel miniature in-line load-cell. The aim was to demonstrate the dependence of the loading-profile experienced by the muscle, on stimulation-frequency and the resistance to shortening in a group of control-animals. Data from these acute-experiments shows the type of loading achievable by means of implantable electrical stimulators activating agonists or agonist/antagonist groups of muscles during programmed resistance-training in freely moving healthy subjects...
April 2017: Physiological Reports
https://www.readbyqxmd.com/read/28420353/the-influence-of-fatigue-and-chronic-low-back-pain-on-muscle-recruitment-patterns-following-an-unexpected-external-perturbation
#17
Júlia Jubany, Lieven Danneels, Rosa Angulo-Barroso
BACKGROUND: Chronic low back pain (CLBP) has been associated with altered trunk muscle responses as well as increased muscle fatigability. CLBP patients and fatigued healthy subjects could experience similar neuromuscular strategies to attempt to protect the spine. The current study examined muscle activation differences between healthy and CLBP subjects following a perturbation. In addition, the possible role of muscle fatigue was evaluated by investigating the healthy control subjects in a non-fatigued and a fatigued condition...
April 19, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28420135/a-prosthetic-hand-body-area-controller-based-on-efficient-pattern-recognition-control-strategies
#18
Simone Benatti, Bojan Milosevic, Elisabetta Farella, Emanuele Gruppioni, Luca Benini
Poliarticulated prosthetic hands represent a powerful tool to restore functionality and improve quality of life for upper limb amputees. Such devices offer, on the same wearable node, sensing and actuation capabilities, which are not equally supported by natural interaction and control strategies. The control in state-of-the-art solutions is still performed mainly through complex encoding of gestures in bursts of contractions of the residual forearm muscles, resulting in a non-intuitive Human-Machine Interface (HMI)...
April 15, 2017: Sensors
https://www.readbyqxmd.com/read/28419981/thiazide-associated-hyponatremia-report-of-the-hyponatremia-registry-an-observational-multicenter-international-study
#19
Volker Burst, Franziska Grundmann, Torsten Kubacki, Arthur Greenberg, Ingrid Becker, Despina Rudolf, Joseph Verbalis
BACKGROUND: Hyponatremia is a frequent and potentially life-threatening adverse side effect of thiazide diuretics. This sub-analysis of the Hyponatremia Registry database focuses on current management practices of thiazide-associated hyponatremia (TAH) and compares differences between TAH and syndrome of inappropriate antidiuretic hormone secretion (SIADH). METHODS: We analyzed 477 patients from 225 US and EU sites with euvolemic hyponatremia ([Na+] ≤130 mEq/L) who were receiving a thiazide diuretic...
April 19, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28419063/the-effect-of-elevated-intracranial-pressure-on-frequency-tuning-of-air-conducted-ocular-vestibular-myogenic-potentials-in-m%C3%A3-ni%C3%A3-re-s-disease-patients
#20
Rebecca Maxwell, Claudia Jerin, Robert Gürkov
OBJECTIVE: To investigate the effect of increased intracranial pressure on ocular vestibular-evoked myogenic potential (oVEMP) amplitudes and frequency tuning in patients with Ménière's disease (MD) to elucidate whether oVEMPS recorded under such conditions could provide a simple and accurate diagnostic test for MD. SETTING: Tertiary referral center for otology and neurotology. PATIENTS: Ten patients with certain unilateral MD (mean age = 48...
April 17, 2017: Otology & Neurotology
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