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https://www.readbyqxmd.com/read/29351614/a-membrane-g-protein-coupled-estrogen-receptor-is-necessary-but-not-sufficient-for-sex-differences-in-zebra-finch-auditory-coding
#1
Amanda A Krentzel, Matheus Macedo-Lima, Maaya Z Ikeda, Luke Remage-Healey
Estradiol acts as a neuromodulator in brain regions important for cognition and sensory processing. Estradiol also shapes brain sex differences, but rarely have these concepts been considered simultaneously. In male and female songbirds, estradiol rapidly increases within the auditory forebrain during song exposure and enhances local auditory processing. We tested whether GPER1, a membrane bound estrogen receptor, is necessary and sufficient for neuroestrogen regulation of forebrain auditory processing in male and female zebra finches (Taeniopygia guttata)...
January 17, 2018: Endocrinology
https://www.readbyqxmd.com/read/29351552/in-situ-recording-of-ionic-currents-in-projection-neurons-and-kenyon-cells-in-the-olfactory-pathway-of-the-honeybee
#2
Jan Kropf, Wolfgang Rössler
The honeybee olfactory pathway comprises an intriguing pattern of convergence and divergence: ~60.000 olfactory sensory neurons (OSN) convey olfactory information on ~900 projection neurons (PN) in the antennal lobe (AL). To transmit this information reliably, PNs employ relatively high spiking frequencies with complex patterns. PNs project via a dual olfactory pathway to the mushroom bodies (MB). This pathway comprises the medial (m-ALT) and the lateral antennal lobe tract (l-ALT). PNs from both tracts transmit information from a wide range of similar odors, but with distinct differences in coding properties...
2018: PloS One
https://www.readbyqxmd.com/read/29351458/differences-in-l-type-calcium-channel-activity-partially-underlie-the-regional-dichotomy-in-pumping-behavior-by-murine-peripheral-and-visceral-lymphatic-vessels
#3
Scott D Zawieja, Jorge A Castorena-Gonzalez, Joshua Scallan, Michael J Davis
We identified a regional dichotomy in murine lymphatic contractile function with regard to vessel location within either the periphery or visceral cavity. All vessels isolated from peripheral regions; cervical, popliteal, inguinal, axillary, and inter-nodal inguinal axillary (Ing-Ax) developed robust contractions with maximal ejection fractions (EFs) of 50-80% in our ex vivo isobaric myograph experiments. Conversely, vessels isolated from the visceral cavity (mesenteric, TD, and iliac) demonstrated maximal EFs below 15%...
January 5, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29351362/analysis-of-the-effect-of-cyclophosphamide-and-methotrexate-on-chrysomya-megacephala-diptera-calliphoridae
#4
Ana Letícia Trivia, Carlos José de Carvalho Pinto
Forensic entomotoxicology investigates the effects of chemical substances in the development of scavenger insects and the reflection on estimating the minimum postmortem interval (PMI). To evaluate the impact of the chemotherapeutic drugs cyclophosphamide (CF) and methotrexate (MTX) on the postembryonic development of Chrysomya megacephala, controlled experiments were performed by rearing the larvae on spiked minced beef with different concentrations of these drugs. The results indicated that CF significantly decreased their developmental rate up to 28 h but had no significant effect on larval and adult sizes, survival rate, and sex ratio, whereas MTX decreased larval and adult sizes, survival rate, and there was a deviation in the expected sex ratio toward females in MTX-exposed larvae but had no significant impact on developmental rate...
January 19, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29351289/the-rumour-spectrum
#5
Nicolas Turenne
Rumour is an old social phenomenon used in politics and other public spaces. It has been studied for only hundred years by sociologists and psychologists by qualitative means. Social media platforms open new opportunities to improve quantitative analyses. We scanned all scientific literature to find relevant features. We made a quantitative screening of some specific rumours (in French and in English). Firstly, we identified some sources of information to find them. Secondly, we compiled different reference, rumouring and event datasets...
2018: PloS One
https://www.readbyqxmd.com/read/29351276/static-length-changes-of-cochlear-outer-hair-cells-can-tune-low-frequency-hearing
#6
Nikola Ciganović, Rebecca L Warren, Batu Keçeli, Stefan Jacob, Anders Fridberger, Tobias Reichenbach
The cochlea not only transduces sound-induced vibration into neural spikes, it also amplifies weak sound to boost its detection. Actuators of this active process are sensory outer hair cells in the organ of Corti, whereas the inner hair cells transduce the resulting motion into electric signals that propagate via the auditory nerve to the brain. However, how the outer hair cells modulate the stimulus to the inner hair cells remains unclear. Here, we combine theoretical modeling and experimental measurements near the cochlear apex to study the way in which length changes of the outer hair cells deform the organ of Corti...
January 19, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29351206/antibody-biomimetic-material-made-of-pyrrole-for-ca-15-3-and-its-application-as-sensing-material-in-ion-selective-electrodes-for-potentiometric-detection
#7
Alexandra R T Santos, Felismina T C Moreira, Luísa A Helguero, M Goreti F Sales
This work reports a very simple approach for creating a synthetic antibody against any protein of interest and its application in potentiometric transduction. The selected protein was Breast Cancer Antigen (CA 15-3), which is implicated in breast cancer disease and used to follow-up breast cancer patients during treatment. The new material with antibody-like properties was obtained by molecular-imprinting technology, prepared by electropolymerizing pyrrol (Py, 5.0 × 10-3 mol/L) around Breast Cancer Antigen (CA 15-3) (100 U/mL) on a fluorine doped tin oxide (FTO) conductive glass support...
January 19, 2018: Biosensors
https://www.readbyqxmd.com/read/29350529/a-colorimetric-dnazyme-biosensor-for-convenience-detection-of-enterotoxin-b-harbouring-staphylococcus-aureus-from-food-samples
#8
Bhairab Mondal, Bhavanashri N, Shylaja Ramlal, Joseph Kingston
In the present study, a colorimetric DNAzymes biosensor strategy was devised in combination with immunomagnetic separation for rapid and easy detection of enterotoxin B harbouring Staphylococcus aureus from food and clinical samples. The method employs immunocapture of S. aureus and amplification of seb gene by DNAzyme complementary sequence integrated forward primer and with specific reverse primer. The DNAzyme sequence integrated dsDNA PCR products when treated with hemin and TMB (3, 3', 5, 5'-tetramethylbenzidine) in the presence of H2O2 produce colorimetric signal...
January 19, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29350524/development-of-a-multiplexed-microsphere-pcr-for-rapid-culture-free-detection-and-gram-typing-of-bacteria-in-human-blood-samples
#9
Fang Liang, Daniel J Browne, Megan J Gray, Kate H Gartlan, David D Smith, Ross Barnard, Geoff R Hill, Simon Robert Corrie, Kate Markey
Blood stream infection is a significant clinical problem, particularly in vulnerable patient groups such as those undergoing chemotherapy and bone marrow transplantation. Clinical diagnostics for suspected blood stream infection remain centered around blood culture (highly variable timing, hours to days), and empiric use of broad-spectrum antibiotics is often employed for patients presenting with febrile neutropenia. Gram-typing provides the first opportunity to target therapy (e.g. combinations containing vancomycin or teicoplanin for Gram-positives; piperacillin-tazobactam or a carbapenem for Gram-negatives), however current approaches require blood culture...
January 19, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29350497/sensitive-and-rapid-determination-of-pyrethroids-in-human-blood-by-gas-chromatography-tandem-mass-spectrometry-with-ultrasound-assisted-dispersive-liquid-liquid-microextraction
#10
Xue Gao, Hao Guo, Junwei Wang, Qingbiao Zhao
In this study, a sensitive and fast procedure of ultrasonic-assisted dispersive liquid-liquid microextraction (UADLLME) coupled with gas chromatography tandem mass spectrometry (GC-MS/MS) for the determination of major pyrethroid pesticides (permethrin, tetramethrin, bifenthrin, fenvalerate, flucythrinate, fluvalinate, fenpropathrin, deltamethrin and cyhalothrin) in blood samples was developed. Response surface methodology (RSM) combined with Box-Behnken design (BBD) and ANOVA function were used to optimize key factors affecting the extraction efficiency of UADLLME procedure...
January 19, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29350471/variability-assessment-of-90-salivary-proteins-in-intra-day-and-inter-day-samples-from-healthy-donors-by-multiple-reaction-monitoring-mass-spectrometry
#11
Yung-Chin Hsiao, Lichieh Julie Chu, Yi-Ting Chen, Lang-Ming Chi, Kun-Yi Chien, Wei-Fan Chiang, Ya-Ting Chang, Szu-Fan Chen, Wei-Shun Wang, Yao-Ning Chuang, Shih-Yu Lin, Chih-Yen Chien, Kai-Ping Chang, Yu-Sun Chang, Jau-Song Yu
PURPOSE: Saliva is an attractive sample source for the biomarker-based testing of several diseases, especially oral cancer. Here, we sought to apply multiplexed LC-MRM-MS to precisely quantify 90 disease-related proteins and assess their intra- and inter-individual variability in saliva samples from healthy donors. EXPERIMENTAL DESIGN: We developed two multiplexed LC-MRM-MS assays for 122 surrogate peptides representing a set of disease-related proteins. Saliva samples were collected from 10 healthy volunteers at three different time points (Day 1 morning and afternoon, and Day 2 morning)...
January 19, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29349846/preparation-of-dummy-template-imprinted-polymers-for-the-rapid-extraction-of-non-steroidal-anti-inflammatory-drugs-residues-in-aquatic-environmental-samples
#12
Ping Guo, Jingjing Zhang, Xiaohui Chen, Longshan Zhao
A molecularly imprinted polymer was synthesized and applied as a sorbent in the solid-phase extraction device. The imprinted polymer was characterized by fourier-transform infrared spectroscopy and scanning electron microscope. The results revealed that imprinted polymer possess sensitive selectivity and reliable adsorption properties for five NSAIDs. The imprinted polymer was successfully applied to the pre-concentration for five NSAIDs in different water samples prior to UPLC-MS/MS. In the early studies, several factors were investigated, including pH adjustment, the kind of elution solvent and the volume of elution solvent...
January 19, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29349664/sparse-functional-identification-of-complex-cells-from-spike-times-and-the-decoding-of-visual-stimuli
#13
Aurel A Lazar, Nikul H Ukani, Yiyin Zhou
We investigate the sparse functional identification of complex cells and the decoding of spatio-temporal visual stimuli encoded by an ensemble of complex cells. The reconstruction algorithm is formulated as a rank minimization problem that significantly reduces the number of sampling measurements (spikes) required for decoding. We also establish the duality between sparse decoding and functional identification and provide algorithms for identification of low-rank dendritic stimulus processors. The duality enables us to efficiently evaluate our functional identification algorithms by reconstructing novel stimuli in the input space...
January 18, 2018: Journal of Mathematical Neuroscience
https://www.readbyqxmd.com/read/29349291/spontaneous-infraslow-fluctuations-modulate-hippocampal-epsp-ps-coupling
#14
Michael B Dash, Stephen Ajayi, Lynde Folsom, Paul E Gold, Donna L Korol
Extensive trial-to-trial variability is a hallmark of most behavioral, cognitive, and physiological processes. Spontaneous brain activity (SBA), a ubiquitous phenomenon that coordinates levels and patterns of neuronal activity throughout the brain, may contribute to this variability by dynamically altering neuronal excitability. In freely-behaving male rats, we observed extensive variability of the hippocampal evoked response across 28-min recording periods despite maintaining constant stimulation parameters of the medial perforant path...
January 2018: ENeuro
https://www.readbyqxmd.com/read/29348639/evidence-of-local-structural-influence-on-the-shape-driven-magnetic-anisotropy-in-electronically-excited-ni-nanoparticles-embedded-in-sio2-matrix
#15
Debalaya Sarker, Saswata Bhattacharya, H Kumar, Pankaj Srivastava, Santanu Ghosh
The reliance of modern electronic era on ultrafast data recording has made the search for novel tools to tune nano-scale magnetic-anisotropy (MA) never-ending. We demonstrate a strong correlation between the spin-spin interactions, local atomic structure and the MA of Ni nanoparticles (NPs) embedded inside SiO2 matrix under swift heavy ion (SHI) irradiation. In contrast to traditional understandings, MA in Ni NPs along with their aspect ratio, first increases upto 5 × 1013 ions/cm2 SHI fluence (5e13) and gets reduced at highest fluence...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348208/learning-to-make-external-sensory-stimulus-predictions-using-internal-correlations-in-populations-of-neurons
#16
Audrey J Sederberg, Jason N MacLean, Stephanie E Palmer
To compensate for sensory processing delays, the visual system must make predictions to ensure timely and appropriate behaviors. Recent work has found predictive information about the stimulus in neural populations early in vision processing, starting in the retina. However, to utilize this information, cells downstream must be able to read out the predictive information from the spiking activity of retinal ganglion cells. Here we investigate whether a downstream cell could learn efficient encoding of predictive information in its inputs from the correlations in the inputs themselves, in the absence of other instructive signals...
January 18, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29348191/multi-modal-encoding-of-novelty-reward-and-learning-in-the-primate-nucleus-basalis-of-meynert
#17
Clarissa Martinez-Rubio, Angelique C Paulk, Eric J McDonald, Alik S Widge, Emad N Eskandar
Associative learning is crucial for daily function, involving a complex network of brain regions. One region, the nucleus basalis of Meynert (NBM), is a highly interconnected, largely cholinergic structure implicated in multiple aspects of learning. We show that single neurons in the NBM of non-human primates (NHPs; N=2 males; Macaca mulatta) encode learning a new association through spike rate modulation. Yet, the power of low-frequency local field potential (LFP) oscillations decreases in response to novel, not-yet-learned stimuli but then increase as learning progresses...
January 18, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29347905/synthesize-of-silver-nanoparticles-by-plant-extract-and-its-application-for-preconcentration-of-cadmium-followed-by-flame-atomic-absorption-spectrometry
#18
Abdul-Hossein Almirtaha, Mohammad Eftekhari, Mahmoud Chamsaz, Mohammad Gheibi
In this paper, menthe pulegium leaves extract was used as a green reducing agent for synthesis of silver-nanoparticles from silver ion solution. The synthesized silver nanoparticles were characterized by ultraviolet-visible spectrophotometry, transmission electron microscopy, X-Ray spectroscopy and used as adsorbent in solid phase extraction for preconcentration of trace levels of cadmium (ІІ). After desorption of cadmium (ІІ) in 5 mol L-1 formic acid, the desorbent solution was aspirated into the flame atomic absorption spectrometry for determination of cadmium...
January 18, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29347806/synchrony-induced-modes-of-oscillation-of-a-neural-field-model
#19
Jose M Esnaola-Acebes, Alex Roxin, Daniele Avitabile, Ernest Montbrió
We investigate the modes of oscillation of heterogeneous ring networks of quadratic integrate-and-fire (QIF) neurons with nonlocal, space-dependent coupling. Perturbations of the equilibrium state with a particular wave number produce transient standing waves with a specific temporal frequency, analogously to those in a tense string. In the neuronal network, the equilibrium corresponds to a spatially homogeneous, asynchronous state. Perturbations of this state excite the network's oscillatory modes, which reflect the interplay of episodes of synchronous spiking with the excitatory-inhibitory spatial interactions...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347720/extreme-events-in-the-forced-li%C3%A3-nard-system
#20
S Leo Kingston, K Thamilmaran, Pinaki Pal, Ulrike Feudel, Syamal K Dana
We observe extremely large amplitude intermittent spikings in a dynamical variable of a periodically forced Liénard-type oscillator and characterize them as extreme events, which are rare, but recurrent and larger in amplitude than a threshold. The extreme events occur via two processes, an interior crisis and intermittency. The probability of occurrence of the events shows a long-tail distribution in both the cases. We provide evidence of the extreme events in an experiment using an electronic analog circuit of the Liénard oscillator that shows good agreement with our numerical results...
November 2017: Physical Review. E
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