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https://www.readbyqxmd.com/read/29353202/validation-of-a-traditional-preparation-against-multi-drug-resistant-salmonella-typhi-and-its-protective-efficacy-in-s-typhimurium-infected-mice
#1
Debprasad Chattopadhyay, Durbadal Ojha, Hemanta Mukherjee, Paromita Bag, Shatrughna Prasad Vaidya, Shanta Dutta
Shorea robusta Gaertn has been used for skin and intestinal ailments in Indian Traditional medicine; while two tribal communities used its tender leaves in 'Meyadi-bukhar' or long-term fever. This prompted us to validate the aqueous and methanol extracts of Shorea robusta tender leaves against wild- and multidrug-resistant clinical isolates of Salmonella enterica Serovar Typhi (S. Typhi), the causative agent of typhoid fever. The antibacterial activity, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and growth inhibition were determined using disc diffusion, agar-and-broth dilution, dose- and time-response assays, along with the safety and protective efficacy in Balb/C mice, infected with S...
January 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29352906/preparation-of-composite-hydroxybutyl-chitosan-sponge-and-its-role-in-promoting-wound-healing
#2
Shihao Hu, Shichao Bi, Dong Yan, Zhongzheng Zhou, Guohui Sun, Xiaojie Cheng, Xiguang Chen
In this work, a composite sponge was produced by physically mixing hydroxybutyl chitosan with chitosan to form a porous spongy material through vacuum freeze-drying. Hydrophilic and macroporous composite hydroxybutyl chitosan sponge was developed via the incorporation of chitosan into hydroxybutyl chitosan. The composite sponge showed higher porosity (about 85%), greater water absorption (about 25 times), better softness and lower blood-clotting index (BCI) than those of chitosan sponge and hydroxybutyl chitosan sponge...
March 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352748/use-of-e-learning-in-clinical-clerkships-effects-on-acquisition-of-dermatological-knowledge-and-learning-processes
#3
Frederike Fransen, Herm Martens, Ivo Nagtzaam, Sylvia Heeneman
Objectives: To obtain a deeper understanding of how the e-learning program, Education in Dermatology (ED), affects the acquisition of dermatological knowledge and the underlying learning processes of medical students in their clinical phase. Methods: The study used a mixed method design with a convergent parallel collection of data. Medical students (n=62) from Maastricht University (The Netherlands) were randomized to either a conventional teaching group (control group n=30) or conventional teaching plus the e-learning program (application on smartphone) group (e-learning group n=32)...
January 17, 2018: International Journal of Medical Education
https://www.readbyqxmd.com/read/29352496/microcystic-adnexal-carcinoma-with-sebaceous-differentiation-three-cases
#4
Angel Fernandez-Flores, Mar Llamas-Velasco, Carles Saus, Anisha Patel, Arno Rutten
Microcystic adnexal carcinoma (MAC) is a low-grade malignant tumor of the skin. Histologically, this tumor shows a biphasic pattern, with cords and nests of basaloid cells, as well as keratin horn cysts. This biphasic histological appearance has been interpreted by some authors as a sign of double eccrine and folliculosebaceous-apocrine differentiation, whereas some other authors defend an solely eccrine differentiation. In this context, sebaceous differentiation in MAC would support the first option. However, there are only three cases of MAC with sebaceous differentiation in the literature, and all of them are previous to adipophilin, which in the appropriate context (for example testing clear cells for sebaceous versus eccrine differentiation) is very useful...
January 20, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29352285/deep-neural-networks-show-an-equivalent-and-often-superior-performance-to-dermatologists-in-onychomycosis-diagnosis-automatic-construction-of-onychomycosis-datasets-by-region-based-convolutional-deep-neural-network
#5
Seung Seog Han, Gyeong Hun Park, Woohyung Lim, Myoung Shin Kim, Jung Im Na, Ilwoo Park, Sung Eun Chang
Although there have been reports of the successful diagnosis of skin disorders using deep learning, unrealistically large clinical image datasets are required for artificial intelligence (AI) training. We created datasets of standardized nail images using a region-based convolutional neural network (R-CNN) trained to distinguish the nail from the background. We used R-CNN to generate training datasets of 49,567 images, which we then used to fine-tune the ResNet-152 and VGG-19 models. The validation datasets comprised 100 and 194 images from Inje University (B1 and B2 datasets, respectively), 125 images from Hallym University (C dataset), and 939 images from Seoul National University (D dataset)...
2018: PloS One
https://www.readbyqxmd.com/read/29351933/vanadium-allergy-following-total-knee-arthroplasty
#6
Fidel Peat, Ross Coomber, Adnan Rana, Alastair Vince
Allergic reactions to metals following joint arthroplasty represent a rare and poorly understood phenomenon. Much is still unknown regarding the natural history of this complication, and how it can best be prevented and managed. We present a case of a 68-year-old woman who underwent a left total knee arthroplasty for treatment of osteoarthritis. After an initial uneventful postoperative course, she developed a troublesome erythematous rash both around the incision site and over her trunk. Blood testing revealed no evidence of infection and clinically her prosthesis was functioning well...
January 18, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29350880/temporal-and-spatial-quantification-of-pain-related-small-fiber-functionality-assessed-using-laser-speckle-contrast-analysis-lasca
#7
Isin Unal-Cevik
BACKGROUND: This study aimed to establish a practical method for assessing pain symptomatology and develop criteria for quantifying small fiber functions, using LASCA. METHODS: Axon flare responses, which reflect small fiber functions, were induced either by histamine or capsaicin applied to the volar surface of the skin of the left forearm. To inhibit small fiber function, local anesthetic cream was applied to the skin of right forearm. The effects on pain symptomatology (severity/timing) and axon flare responses (temporal/spatial characteristics) were measured using LASCA...
January 19, 2018: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29350788/reliability-and-validity-of-the-atopic-dermatitis-symptom-score
#8
Ji Young Lee, Minji Kim, Hea-Kyoung Yang, Hyun Mi Kim, Joongbum Cho, Young-Min Kim, In Seok Lim, Hae-Kwan Cheong, Hye Seung Kim, Insuk Sohn, Jihyun Kim, Kangmo Ahn
BACKGROUND: We have developed the Atopic Dermatitis Symptom Score (ADSS) by which patients or parents can easily assess and record AD symptoms on a daily basis in a smartphone application. The aim of the present study was to evaluate the reliability and validity of the ADSS. METHODS: We enrolled 307 children and adolescents with AD. Parents or caregivers were asked to record daily symptoms of the patients (itching, sleep disturbance, erythema, dryness, oozing, and oedema) using a scale of 0 to 4...
January 19, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29350376/an-unexpected-long-term-complication-of-genital-burn-in-a-child-secondary-cryptorchidism
#9
Mustafa Öksüz, Hasan Deliağa, Adem Topkara, Ömer Faruk Koçak
Genital and perineal burns are rare and challenging injuries with serious long-term complications. Involvement of the testes is a sign of severity. There is limited knowledge in the literature about the management of complications and testes involvement in genital and perineal burns. In this report, we present the case of an 8-year-old boy with secondary cryptorchidism due to burn contracture who was treated by increasing the scrotal volume by Z-plasties, skin graft, and orchidopexy.
January 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29350263/histological-findings-after-argon-plasma-coagulation-an-ex-vivo-study-revealing-a-possible-role-in-superficial-ablative-treatment-of-the-skin
#10
L Schmitz, S Hessam, L Scholl, S Reitenbach, M H Segert, T Gambichler, E Stockfleth, F G Bechara
Argon plasma coagulation (APC) is an electrosurgical technique which can be used to ablate skin lesions with limited invasion depth into dermal tissue. Hence, APC might be well suited for the removal of epithelial tumours. However, there are no data on the effects of APC on human skin tissue. Thus, the aim of this study was to determine the extent of epidermal and dermal damage after APC of human skin. We performed APC ex-vivo on 91 freshly resected human skin samples, which were obtained after reconstructive surgical closures in actinically damaged areas...
January 19, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29350017/skin-prick-test-analysis-reveals-cross-sensitization-to-tomato-profilin-and-grass-pollen-in-nasobronchialallergic-patients-with-history-of-tomato-food-allergy
#11
V L Hegde, P A Mahesh, Y P Venkatesh
The association between grass pollen sensitization and food allergy to tomato is of great interest. We report here, the first such study in Indian population. We investigated 246 allergic rhinitis / asthma patients by diagnostic case history and skin prick test (SPT); grass pollen mix, tomato extract and purified tomato profilin were used for SPT. Tomato profilin was purified by affinity chromatography, and analyzed by HPLC (95% purity) and SDS-PAGE (14 kDa). We observed that 38% of the patients had sensitization to both grass pollen and tomato fruit, of which 92% were sensitized to tomato profilin...
January 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29350016/biomarkers-of-treatment-efficacy-in-patients-with-chronic-spontaneous-urticaria
#12
M Sánchez-Borges, A Capriles-Hulett, F Caballero-Fonseca, L González-Aveledo
Background. Currently there are no biomarkers useful to predict the future evolution and the therapeutic response in patients with chronic spontaneous urticaria (CSU). Objective. To review the available information on biomarkers that might be applied for the follow up of the response to guideline recommended therapies for CSU. Methods. A review of the medical literature on CSU potential clinical and laboratory biomarkers in PubMed and MEDLINE including the terms urticaria, chronic urticaria, chronic idiopathic urticaria, chronic spontaneous urticaria, antihistamines (AHs), omalizumab (OMA), cyclosporine (CyA), and treatment...
January 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29349807/possible-role-of-plasmacytoid-dendritic-cells-in-pityriasis-lichenoides
#13
M Karouni, J Abou Rahal, M Kurban, A G Kibbi, O Abbas
BACKGROUND: Plasmacytoid dendritic cells (pDCs) and their product, type I interferons (IFNs), have been implicated in the pathogenesis of several skin disorders characterized by an interface dermatitis (ID) pattern, such as lichen planus (LP). A type I IFN signature has previously been documented in pityriasis lichenoides (PL). Although pDCs are known to be the main source and most potent producers of local type I IFNs, their role in PL has not been investigated. AIM: To investigate the role of pDCs in PL...
January 19, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29349713/patient-reported-outcomes-of-catheter-based-accelerated-partial-breast-brachytherapy-and-whole-breast-irradiation-a-single-institution-experience
#14
Krishan R Jethwa, Mohamed M Kahila, Kristin C Mara, William S Harmsen, David M Routman, Geralyn M Pumper, Kimberly S Corbin, Jeff A Sloan, Kathryn J Ruddy, Tina J Hieken, Sean S Park, Robert W Mutter
PURPOSE: Accelerated partial breast irradiation (APBI) and whole breast irradiation (WBI) are treatment options for early-stage breast cancer. The purpose of this study was to compare patient-reported-outcomes (PRO) between patients receiving multi-channel intra-cavitary brachytherapy APBI or WBI. METHODS: Between 2012 and 2015, 131 patients with ductal carcinoma in situ (DCIS) or early stage invasive breast cancer were treated with adjuvant APBI (64) or WBI (67) and participated in a PRO questionnaire...
January 18, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29348181/intensity-of-exposure-to-pulmonary-tuberculosis-determines-risk-of-tuberculosis-infection-and-disease
#15
Carlos Acuña-Villaorduña, Edward C Jones-López, Geisa Fregona, Patricia Marques-Rodrigues, Mary Gaeddert, Carolina Geadas, David Jamil Hadad, Laura F White, Lucilia Pereira Dutra Molina, Solange Vinhas, Rodrigo Ribeiro-Rodrigues, Padmini Salgame, Moises Palaci, David Alland, Jerrold J Ellner, Reynaldo Dietze
Household contacts of pulmonary tuberculosis (TB) patients are at increased risk of TB infection and disease. However, their risk in relation to the intensity of exposure remains unknown.We studied smear-positive TB cases and their household contacts in Vitória, Brazil. We collected clinical, demographic and radiographic information from TB cases, and obtained tuberculin skin test (TST) and QuantiFERON-TB Gold (QFT) results from household contacts. We measured intensity of exposure using a proximity score and sleep location in relation to the TB index case and defined infection by TST ≥10 mm or QFT ≥0...
January 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29348110/the-role-of-ethnicity-and-environment-in-the-regulation-of-response-to-sensory-stimulus-in-children-protocol-and-pilot-findings-of-a-neurophysiological-study
#16
Ivan Neil Gomez, Cynthia Yy Lai, Chetwyn Ch Chan, Hector Wh Tsang
BACKGROUND: The ability to regulate the response to sensory stimuli has been associated with successful behavioral patterns necessary for daily activities. However, it is not known whether a child's ethnicity and environment can influence autonomic regulatory mechanisms. OBJECTIVE: This study aims to explore the role of ethnicity and environment in the regulation of responses to sensory stimuli in children. METHODS: In this study, we intend to recruit 128 children from different ethnic groups or environment contexts as follows: (1) 32 typically developing Chinese children living in Hong Kong; (2) 32 typically developing Filipino children living in Hong Kong; (3) 32 typically developing Filipino children who are living in urban areas; and (4) 32 typically developing Filipino children who are living in rural areas in Philippines...
January 18, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29347950/the-microrna-15a-pai-2-axis-in-cholangiocarcinoma-associated-fibroblasts-promotes-migration-of-cancer-cells
#17
Penkhae Utaijaratrasmi, Kulthida Vaeteewoottacharn, Takaaki Tsunematsu, Pranisa Jamjantra, Sopit Wongkham, Chawalit Pairojkul, Narong Khuntikeo, Naozumi Ishimaru, Yongyut Sirivatanauksorn, Ananya Pongpaibul, Peti Thuwajit, Chanitra Thuwajit, Yasusei Kudo
BACKGROUND: Cholangiocarcinoma (CCA) has an abundance of tumor stroma which plays an important role in cancer progression via tumor-promoting signals. This study aims to explore the microRNA (miRNA) profile of CCA-associated fibroblasts (CCFs) and the roles of any identified miRNAs in CCA progression. METHODS: miRNA expression profiles of CCFs and normal skin fibroblasts were compared by microarray. Identified downregulated miRNAs and their target genes were confirmed by real-time PCR...
January 18, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29346384/histoplasmosis-in-africa-an-emerging-or-a-neglected-disease
#18
REVIEW
Rita O Oladele, Olusola O Ayanlowo, Malcolm D Richardson, David W Denning
Histoplasmosis in Africa has markedly increased since the advent of the HIV/AIDS epidemic but is under-recognised. Pulmonary histoplasmosis may be misdiagnosed as tuberculosis (TB). In the last six decades (1952-2017), 470 cases of histoplasmosis have been reported. HIV-infected patients accounted for 38% (178) of the cases. West Africa had the highest number of recorded cases with 179; the majority (162 cases) were caused by Histoplasma capsulatum var. dubuosii (Hcd). From the Southern African region, 150 cases have been reported, and the majority (119) were caused by H...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29345220/tissue-impression-smears-as-a-supplementary-diagnostic-method-for-histopathology-in-cutaneous-leishmaniasis-in-sri-lanka
#19
Nuwani H Manamperi, M Vipula C de Silva, Nishantha Pathirana, Wimal Abeyewickreme, Nadira D Karunaweera
Cutaneous leishmaniasis (CL) is diagnosed mainly by light microscopy of smears made using lesion material. Histopathology is usually done in atypical presentations or when lesion smears are negative. Tissue impression smears (TIS) made from skin biopsy specimens were compared with histopathology for the diagnosis of CL. Out of the 111 patients included, 83 (74.8%) were positive by either methods. The TIS was positive in 70.3% whereas histopathology was positive in 56.8% of patients. Tissue impression smears can be used as a supplementary diagnostic test that gives sensitive and rapid results when tissue biopsies are used as the source of lesion material for diagnosis of CL...
January 15, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29345081/screening-for-latent-tuberculosis-infection-among-patients-with-rheumatoid-arthritis-in-the-era-of-biologics-and-targeted-synthetic-disease-modifying-anti-rheumatic-drugs-in-india-a-high-burden-tb-country-the-importance-of-mantoux-and-quantiferon-tb-gold-tests
#20
Anand N Malaviya, Vishal K Aggarwal, Roopa Rawat, Sadhana Baghel, Ravita Thakran, Qamar Zaheer, Shriram Garg, Sanjiv Kapoor
AIM: To test the validity of an augmented tuberculosis skin test (a-TST) combined with Quantiferon TB-gold® (QFTG) test for the screening of latent tuberculosis infection (LTBI) in patients with rheumatoid arthritis (RA) being considered for treatment with biologic disease-modifying anti-rheumatic drugs or targeted synthetic disease-modifying anti-rheumatic drugs. METHOD: Standard TST using 1 tuberculin unit (TU) of purified protein derivative (PPD, RT23 strain) was carried out...
January 17, 2018: International Journal of Rheumatic Diseases
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