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https://www.readbyqxmd.com/read/28945013/pro-regenerative-hydrogel-restores-scarless-skin-during-cutaneous-wound-healing
#1
Guoming Sun
The transformation of fibrotic healing process to regenerative one has great potential to fully restore wounded skin. The M2 macrophage phenotype promotes constructive tissue remodeling and instructs tissue repair in a regenerative manner. It is hypothesized that hydrogels that can establish robustness of endogenous cells to regulate M2 phenotype will promote constructive dermal remodeling. Toward this end, a series of dextran-based bioabsorbable hydrogels are developed and self-crosslinkable dextran-isocyanatoethyl methacrylate-ethylamine (DexIEME) is identified as the potential scaffold...
September 25, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28944559/harnessing-photochemical-shrinkage-in-direct-laser-writing-for-shape-morphing-of-polymer-sheets
#2
Anton A Bauhofer, Sebastian Krödel, Jan Rys, Osama R Bilal, Andrei Constantinescu, Chiara Daraio
Structures that change their shape in response to external stimuli unfold possibilities for more efficient and versatile production of 3D objects. Direct laser writing (DLW) is a technique based on two-photon polymerization that allows the fabrication of microstructures with complex 3D geometries. Here, it is shown that polymerization shrinkage in DLW can be utilized to create structures with locally controllable residual stresses that enable programmable, self-bending behavior. To demonstrate this concept, planar and 3D-structured sheets are preprogrammed to evolve into bio-inspired shapes (lotus flowers and shark skins)...
September 25, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28944496/the-unidirectional-hypoxia-activated-prodrug-oct1002-inhibits-growth-and-vascular-development-in-castrate-resistant-prostate-tumors
#3
Heather Nesbitt, Jenny Worthington, Rachel J Errington, Laurence H Patterson, Paul J Smith, Stephanie R McKeown, Declan J McKenna
BACKGROUND: OCT1002 is a unidirectional hypoxia-activated prodrug (uHAP) OCT1002 that can target hypoxic tumor cells. Hypoxia is a common feature in prostate tumors and is known to drive disease progression and metastasis. It is, therefore, a rational therapeutic strategy to directly target hypoxic tumor cells in an attempt to improve treatment for this disease. Here we tested OCT1002 alone and in combination with standard-of-care agents in hypoxic models of castrate-resistant prostate cancer (CRPC)...
September 24, 2017: Prostate
https://www.readbyqxmd.com/read/28944437/no-effect-of-insect-repellents-on-the-behaviour-of-lymnaea-stagnalis-at-environmentally-relevant-concentrations
#4
Patrick Fink, Eric von Elert
Insect repellents are widely applied to various materials and to both human and animal skin to deter mosquitoes and ticks. The most common deterrent compounds applied are DEET, EBAAP and icaridin (picaridin, Bayrepel). Due to their extensive application, these repellents are frequently detected in surface waters in considerable concentrations. As these compounds are designed to alter invertebrates' behaviour rather than to intoxicate them, we hypothesised that insect repellents have the potential to modify the natural behaviour of non-target invertebrates in natural freshwater bodies...
September 24, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28944135/management-of-syndromic-diarrhea-tricho-hepato-enteric-syndrome-a-review-of-the-literature
#5
REVIEW
Alexandre Fabre, Patrice Bourgeois, Marie-Edith Coste, Céline Roman, Vincent Barlogis, Catherine Badens
Syndromic diarrhea/tricho-hepato-enteric syndrome (SD/THE) is a rare disease linked to the loss of function of either TTC37 or SKIV2L, two components of the SKI complex. It is characterized by a combination of 9 signs (intractable diarrhea, hair abnormalities, facial dysmorphism, immune abnormalities, IUGR/SGA, liver abnormalities, skin abnormalities, congenital heart defect and platelet abnormalities). We present a comprehensive review of the management of SD/THE and tested therapeutic regimens. A review of the literature was conducted in May 2017: 29 articles and 2 abstracts were included describing a total of 80 patients, of which 40 presented with mutations of TTC37, 14 of SKIV2L...
August 2017: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/28943917/mechanisms-of-cxcr7-induction-in-malignant-melanoma-development
#6
Xiao-Jing Li, Pai Liu, Wei-Wei Tian, Zhi-Feng Li, Bao-Guo Liu, Jian-Fang Sun
Malignant melanoma (MM) is a highly malignant skin tumor. The mechanism of MM pathogenesis and its signaling pathways are not well characterized. C-X-C chemokine receptor type 7 (CXCR7) has been reported to regulate cancer cell invasion. The present study sought to investigate the effects of CXCR7 on MM development. First, CXCR7 expression levels were assessed in the skin tumor tissue of patients with MM. Then, CXCR7 small hairpin RNA was used in M14 melanoma cells in a Transwell culture model and in a transplanted mouse model to test the effects of CXCR7...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943492/comparison-of-clinical-outcomes-of-multi-point-umbrella-suturing-and-single-purse-suturing-with-two-point-traction-after-procedure-for-prolapse-and-hemorrhoids-pph-surgery
#7
Huiyong Jiang, Xiuyan Hao, Ying Xin, Youzhen Pan
OBJECTIVES: To compare the clinical outcomes of multipoint umbrella suture and single-purse suture with two-point traction after procedure for prolapse and hemorrhoids surgery (PPH) for the treatment of mixed hemorrhoids. METHODS: Ninety patients were randomly divided into a PPH plus single-purse suture group (Group A) and a PPH plus multipoint umbrella suture (Group B). All operations were performed by an experienced surgeon. Operation time, width of the specimen, hemorrhoids retraction extent, postoperative pain, postoperative bleeding, and length of hospitalization were recorded and compared...
September 21, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28943471/childhood-chronic-prurigo-interest-of-patch-tests-and-delayed-reading-skin-prick-tests-to-environmental-allergens
#8
Claire Maridet, Martin Perromat, Juliette Miquel, Christine Chiaverini, Didier Bessis, Audrey Lasek, Maryam Piram, Anne-Claire Bursztejn, Claire Abasq, Alice Phan, Ludovic Martin, Bérénice Bréchat, Jin Ho Chong, Julien Seneschal, Alain Taïeb, Franck Boralevi
Childhood chronic prurigo is rarely studied in particular for allergic components. We propose a clinical classification according to seasonality of prurigo in three groups to help identifying causal agents and guide allergy testing with delayed readings tests.
September 21, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28943208/preparation-of-mixed-monoterpenes-edge-activated-pegylated-transfersomes-to-improve-the-in-vivo-transdermal-delivery-efficiency-of-sinomenine-hydrochloride
#9
Juan Wang, Yan Wei, Ya-Rong Fei, Li Fang, Hang-Sheng Zheng, Chao-Feng Mu, Fan-Zhu Li, Yong-Sheng Zhang
Surfactants generally have been used as edge activators of transfersomes. However, surfactants edge activated transfersomes frequently lead to cutaneous irritation, skin lipid loss and other side effects after dermal administration. In this study, mixed monoterpenes edge activated PEGylated transfersomes (MMPTs) were prepared by ethanol injection process with sinomenine hydrochloride as a model drug. The formulation of MMPTs was optimized by an orthogonal design. We investigated skin permeation/deposition characteristics and pharmacokinetics of sinomenine hydrochloride loaded in MMPTs by comparing with liposomes using in vitro skin tests and in vivo cutaneous microdialysis...
September 21, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28942756/association-between-schizophrenia-and-an-autoimmune-bullous-skin-disease-pemphigus-a-population-based-large-scale-study
#10
K Kridin, S Zelber-Sagi, D Comaneshter, A D Cohen
AIMS: Immunological hypotheses have become increasingly prominent suggesting that autoimmunity may be involved in the pathogenesis of schizophrenia. Schizophrenia was found to be associated with a wide range of autoimmune diseases. However, the association between pemphigus and schizophrenia has not been established yet. We aimed to estimate the association between pemphigus and schizophrenia using a large-scale real-life computerised database. METHODS: This study was conducted as a cross-sectional study utilising the database of Clalit Health Services...
September 25, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/28942361/extracellular-and-non-chaperone-function-of-heat-shock-protein-90alpha-hsp90%C3%AE-is-required-for-skin-wound-healing
#11
Ayesha Bhatia, Kathryn O'Brien, Jiacong Guo, Vadim Lincoln, Chiaki Kajiwara, Mei Chen, David T Woodley, Heiichiro Udono, Wei Li
Despite years of effort and investment, there are few topical or systemic medications for skin wounds. Identifying natural "drivers" of wound healing could facilitate the development of new and effective treatments. When skin is injured, there is a massive increase of heat shock protein 90alpha (Hsp90α) protein inside the wound bed. The precise role for these Hsp90α proteins, however, was unclear. The availability of a unique mouse model that lacked the intracellular ATPase-driven chaperoning, but spared the extracellular F-5-supported pro-motility, function of Hsp90α allowed us to test specifically the role of the non-chaperone function of Hsp90α in normal wound closure...
September 20, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28941934/effects-of-dietary-nitrate-supplementation-on-the-response-to-extremity-cooling-and-endothelial-function-in-individuals-with-cold-sensitivity-a-double-blind-placebo-controlled-crossover-randomised-control-trial
#12
Clare M Eglin, Joseph T Costello, Stephen J Bailey, Mark Gilchrist, Heather Massey, Anthony I Shepherd
Individuals with cold sensitivity have low peripheral skin blood flow and skin temperature possibly due to reduced nitric oxide (NO•) bioavailability. Beetroot has a high concentration of inorganic nitrate and may increase NO-mediated vasodilation. Using a placebo-controlled, double blind, randomised, crossover design, this study tested the hypotheses that acute beetroot supplementation would increase the rate of cutaneous rewarming following a local cold challenge and augment endothelium-dependent vasodilation in cold sensitive individuals...
September 20, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28941682/lc-ms-profiling-highlights-hazelnut-nocciola-di-giffoni-pgi-shells-as-a-byproduct-rich-in-antioxidant-phenolics
#13
Milena Masullo, Antonietta Cerulli, Angela Mari, Carla Clisiane de Souza Santos, Cosimo Pizza, Sonia Piacente
The Italian "Nocciola di Giffoni", also known as "Tonda di Giffoni", a labelled Protected Geographical Indication (PGI) product, represents an important economic resource for the Italian market. The methanol (MeOH) extract of "Tonda di Giffoni" shells has been investigated for the phenolic content, assayed by the Folin-Ciocalteu method, and for the antioxidant activity by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and Trolox Equivalent Antioxidant Capacity (TEAC) assays. In order to achieve deeper insight into the chemical composition of the shells of hazelnut "Nocciola di Giffoni" and to highlight the occurrence of biologically active compounds, a phytochemical investigation was carried out...
November 2017: Food Research International
https://www.readbyqxmd.com/read/28940850/sensitisation-to-fungi-in-atopic-dermatitis-patients-older-14-years-of-age-and-the-relation-to-the-occurrence-of-food-hypersensitivity-reactions
#14
J Čelakovská, J Bukač, K Ettler, J Vaneckova, I Krcmova, K Ettlerova
The aim of this study is the evaluation, if there is some relation between the sensitisation to fungi and the occurrence of food hypersensitivity reactions in atopic dermatitis patients aged 14 years and older. The complete dermatological and allergological examinations were perfomed in all included patients; the occurrence of food hypersensitivity reactions was recorded and the sensitisation to mixture of fungi was examined (skin prick test, specific IgE). The statistical evaluation of the relation between the sensitisation to fungi and the occurrence of food hypersensitivity reactions was performed; 331 patients were included in the study, 110 men and 221 women, the average age 26...
September 22, 2017: Mycoses
https://www.readbyqxmd.com/read/28940644/inducible-t-cell-costimulator-icos-and-cd28-polymorphisms-possibly-play-a-role-in-the-pathogenesis-of-chronic-autoreactive-urticaria
#15
Z Brzoza, W Grzeszczak, W Trautsolt, D Moczulski
BACKGROUND: Clinical experience emphasizes the coexistence of chronic spontaneous urticaria (CSU) and autoimmune disturbances. In chromosome 2q33-34, there is a cluster of homologous genes that are considered promising candidate genes for susceptibility to autoimmune diseases. AIM: To examine the possible role of polymorphisms in the genes for CD28 and inducible T-cell costimulator (ICOS) in the background of CSU. METHODS: In total, 149 patients with CSU with positive autologous serum skin test were enrolled in the study...
September 20, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28940586/comparative-instrumental-evaluation-of-efficacy-and-safety-between-a-binary-and-a-ternary-system-in-chemexfoliation
#16
Norma Cameli, Maria Mariano, Marco Ardigò, Cristina Corato, Gianfranco De Paoli, Enzo Berardesca
OBJECTIVE: To instrumentally evaluate the efficacy and the safety of a new ternary system chemo exfoliating formulation (water-dimethyl isosorbide-acid) vs traditional binary systems (water and acid) where the acid is maintained in both the systems at the same concentration. METHODS: Different peelings (binary system pyruvic acid and trichloroacetic acid-TCA, and ternary system pyruvic acid and TCA) were tested on the volar forearm of 20 volunteers of both sexes between 28 and 50 years old...
September 20, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28940252/tobacco-exposure-and-wound-healing-in-head-and-neck-surgical-wounds
#17
Amy Anne D Lassig, Joan E Bechtold, Bruce R Lindgren, Andrew Pisansky, Abayo Itabiyi, Bevan Yueh, Anne M Joseph
OBJECTIVE: Smoking impairs wound healing, yet the underlying pathophysiological mechanisms are unclear. We evaluated tobacco-altered healing in head and neck surgery by studying the association between biomarkers and tobacco exposure, as well as cutaneous perfusion by smoking status. STUDY DESIGN: Prospective cohort study, tertiary/academic care center, 2011 to present. METHODS: Patients who required head and neck surgery were enrolled prospectively...
September 20, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28940028/plasticity-of-skin-water-permeability-and-skin-thickness-in-the-amphibious-mangrove-rivulus-kryptolebias-marmoratus
#18
Quentin Heffell, Andy J Turko, Patricia A Wright
The skin of amphibious fishes is a multipurpose organ, important for gas and ion exchange and nitrogen excretion when fish are out of water (emersed). We tested the hypothesis that skin permeability is altered to maintain water balance through changes in water permeability and skin thickness during salinity acclimation and/or when fish emerse, using the euryhaline, amphibious fish Kryptolebias marmoratus as a model. We first recorded the behaviour of fish out of water to determine which part of the cutaneous surface was in contact with the substrate...
September 22, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28939607/multidrug-and-mupirocin-resistance-in-environmental-methicillin-resistant-staphylococcus-aureus-mrsa-collected-from-the-homes-of-people-diagnosed-with-a-community-onset-co-mrsa-infection
#19
J H Shahbazian, P D Hahn, S Ludwig, J Ferguson, P Baron, A Christ, K Spicer, P Tolomeo, A M Torrie, W B Bilker, V C Cluzet, B Hu, K Julian, I Nachamkin, S C Rankin, D O Morris, E Lautenbach, M F Davis
Patients with community-onset methicillin-resistant Staphylococcus aureus (CO-MRSA) infections contribute to MRSA contamination of the home environment, and may be re-exposed to MRSA strains from this reservoir. This study evaluates One Health risk factors that focus on the relationship between humans, animals and the environment for increased prevalence of multiple antimicrobial resistant MRSA in the home environment. During a trial of patients with CO-MRSA infection, MRSA was isolated from the household environment at baseline and three months later, following randomization of patients and household members to mupirocin-based decolonization therapy or education control...
September 22, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28939564/the-effects-of-ph-and-pi-on-tension-and-ca-2-sensitivity-of-ventricular-myofilaments-from-the-anoxia-tolerant-painted-turtle
#20
Cornelia E Fanter, Kenneth S Campbell, Daniel E Warren
We aimed to determine how increases in intracellular H(+) and inorganic phosphate (Pi) to levels observed during anoxic submergence affect contractility in ventricular muscle of the anoxia-tolerant Western painted turtle, Chrysemys picta bellii Skinned multicellular preparations were exposed to six treatments with physiologically relevant levels of pH (7.4, 7.0, 6.6), and Pi (3 mM and 8 mM). Each preparation was tested in a range of calcium concentrations (pCa 9.0-pCa 4.5) to determine the pCa-tension relationship for each treatment...
September 22, 2017: Journal of Experimental Biology
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