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https://www.readbyqxmd.com/read/29785902/milk-microrna-146a-as-a-potential-biomarker-in-bovine-tuberculosis
#1
Marco Iannaccone, Gianfranco Cosenza, Alfredo Pauciullo, Francesca Garofalo, Yolande T Proroga, Federico Capuano, Rosanna Capparelli
In this research communication we exploited the potential use of milk microRNAs (miRs) as biomarkers for bovine tuberculosis (bTB). bTB is a zoonotic disease caused by Mycobacterium bovis which affects animal health, influencing herd economic sustainability. Diagnosis is based on skin delayed-type hypersensitivity reaction and quantification of interferon gamma but both techniques are influenced by several confounding factors. Thus, new methods for early diagnosis are required. In this context, microRNAs have been used as promising biomarkers for both infectious and non-infectious diseases...
May 2018: Journal of Dairy Research
https://www.readbyqxmd.com/read/29785566/delineating-a-new-feature-of-constitutional-mismatch-repair-deficiency-cmmrd-syndrome-breast-cancer
#2
Lisa Bush, Melyssa Aronson, Uri Tabori, Brittany B Campbell, Raymond B Bedgood, Kory Jasperson
Constitutional mismatch repair deficiency (CMMRD) syndrome is a rare autosomal recessive hereditary cancer condition, characterized by an exceptionally high risk of cancer, a propensity for childhood malignancies, and cutaneous features reminiscent of neurofibromatosis type 1 (NF1). We report on two sisters originally suspected of having CMMRD syndrome due to their history of colonic polyps and NF1 associated skin findings, both were subsequently found to have biallelic MSH6 mutations. After years of CMMRD syndrome follow-up, the proband was diagnosed with breast cancer at age 29, while her sister was diagnosed with a glioblastoma at age 27...
May 21, 2018: Familial Cancer
https://www.readbyqxmd.com/read/29785324/-staphylococcus-aureus-is-the-most-common-bacterial-agent-of-the-skin-flora-of-patients-with-seborrheic-dermatitis
#3
Funda Tamer, Mehmet Eren Yuksel, Evren Sarifakioglu, Yavuz Karabag
Background: Seborrheic dermatitis is an inflammatory skin disease that affects 1-3% of the general population. The Malassezia species has been implicated as the main causative agent; however, the bacterial flora of the skin may also play role in the etiopathogenesis. Therefore, we investigated the most common bacterial agent of the skin flora of patients with seborrheic dermatitis. Materials and Methods: Fifty-one patients with seborrheic dermatitis and 50 healthy individuals are included in this study...
April 2018: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29784619/parental-touch-reduces-social-vigilance-in-children
#4
Eddie Brummelman, David Terburg, Miranda Smit, Susan M Bögels, Peter A Bos
The sense of touch develops in utero and enables parent-child communication from the earliest moments of life. Research shows that parental touch (e.g., licking and grooming in rats, skin-to-skin care in humans) has organizing effects on the offspring's stress system. Little is known, however, about the psychological effects of parental touch. Building on findings from ethology and psychology, we propose that parental touch-even as subtle as a touch on the shoulder-tells children that their environment is safe for exploration, thus reducing their social vigilance...
May 9, 2018: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29783722/the-occurrence-of-a-commercial-n-pro-and-e-rns-double-mutant-bvdv-1-live-vaccine-strain-in-newborn-calves
#5
Kerstin Wernike, Anna Michelitsch, Andrea Aebischer, Uwe Schaarschmidt, Andrea Konrath, Hermann Nieper, Julia Sehl, Jens P Teifke, Martin Beer
The major source for the spread of bovine viral diarrhea virus (BVDV) are in-utero infected, immunotolerant, persistently infected (PI) animals since they shed enormous amounts of viruses throughout their lives. During the sequence-based virus typing of diagnostic ear notch samples performed in the context of the obligatory German BVDV eradication program, the commercial Npro and Erns double mutant BVDV-1 live-vaccine strain KE-9 was detected in seven newborn calves; their mothers were immunized in the first trimester of gestation...
May 19, 2018: Viruses
https://www.readbyqxmd.com/read/29782954/comparison-between-disk-diffusion-and-agar-dilution-methods-to-determine-in-vitro-susceptibility-of-corynebacterium-spp-clinical-isolates-and-update-of-their-susceptibility
#6
Claudia Barberis, Eugenia Sandoval, Carlos Hernán Rodriguez, María Soledad Ramírez, Angela Famiglietti, Marisa Almuzara, Carlos Vay
INTRODUCTION: Although Corynebacterium species are part of the skin and mucous membranes microbiota, human infections caused by Corynebacterium spp. have been reported and the multidrug resistance pattern of the recovered isolates was emphasized. Due to the usefulness of disk diffusion in daily practice, the purpose of this work was to compare disk diffusion against agar dilution to determine disk diffusion breakpoints and to review the antimicrobial susceptibility of the most frequent Corynebacterium spp...
May 18, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29782522/molecular-detection-of-mycobacterium-ulcerans-in-the-environment-and-its-relationship-with-buruli-ulcer-occurrence-in-zio-and-yoto-districts-of-maritime-region-in-togo
#7
Issaka Maman, Tchadjobo Tchacondo, Abiba Banla Kere, Marcus Beissner, Kossi Badziklou, Ekanao Tedihou, Edith Nyaku, Komi Amekuse, Franz Xaver Wiedemann, Damintoti Simplice Karou, Gisela Bretzel
BACKGROUND: Buruli Ulcer (BU) is a neglected tropical skin infection caused by Mycobacterium ulcerans. Residence near aquatic areas has been identified as an important source of transmission of M. ulcerans with increased risk of contracting Buruli ulcer. However, the reservoir and the mode of transmission are not yet well known. The aim of this study was to identify the presence of M. ulcerans in the environment and its relationship with Buruli ulcer occurrence in Zio and Yoto districts of the maritime region in south Togo...
May 21, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29782497/exploration-of-alternative-test-methods-to-evaluate-phototoxicity-of-ophthalmic-agents-by-using-statens-seruminstitut-rabbit-cornea-cell-lines-and-3d-human-reconstituted-cornea-models
#8
Soyoung Kim, Ki Hwan Choi, Jaesuk Yun
Many chemicals have been reported to induce phototoxicity. The absorbance of light energy within the sunlight range is a common characteristic of phototoxicity. The 3T3 NRU phototoxicity test (PT) in 3T3 mouse skin fibroblasts has been used to identify the phototoxic potential induced by excited chemicals after exposure to ultra violet (UV). However, as phototoxicity may occur in ocular cells, it is necessary to develop a more suitable test for cornea-derived cells. In this study, we attempted to establish a new in vitro PT method in rabbit corneal cell lines (SIRC)...
2018: PloS One
https://www.readbyqxmd.com/read/29782495/molecular-immunological-and-neurophysiological-evaluations-for-early-diagnosis-of-neural-impairment-in-seropositive-leprosy-household-contacts
#9
Diogo Fernandes Dos Santos, Matheus Rocha Mendonça, Douglas Eulálio Antunes, Elaine Fávaro Pípi Sabino, Raquel Campos Pereira, Luiz Ricardo Goulart, Isabela Maria Bernardes Goulart
BACKGROUND: Household contacts constitute the highest risk group for leprosy development, and despite significant progress in the disease control, early diagnosis remains the primary goals for leprosy management programs. METHODS: We have recruited 175 seropositive and 35 seronegative household contacts from 2014 to 2016, who were subjected to an extensive protocol that included clinical, molecular (peripheral blood qPCR, slit-skin smear qPCR, skin biopsy qPCR) and electroneuromyographic evaluations...
May 21, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29782307/cutaneous-manifestations-of-tuberous-sclerosis
#10
Mirjana Bakić, Marina Ratković, Branka Gledović, Balsa Vujović, Danilo Radunović, Vera Babić, Vladimir Prelević
Dear Editor, Tuberous sclerosis (TS) is an autosomal dominant multisystem disease, which occurs due to genetically determined hyperplasia of ectodermal and mesodermal cells. Clinical manifestations present on the skin and in the nervous system, kidneys, heart, and other organs. Recent studies estimate the incidence of TS at 1/6000 to 1/10,000 live births, and a prevalence in the general population of approximately 1 in 20,000 (1). There are two different genetic loci responsible for TS: 9q34 (TSC1-hamartin) and 16p13...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29782306/urticarial-lesions-in-a-pregnant-woman
#11
Sergio Santos-Alarcón, Cesar Benavente-Villegas, Isabel García-Briz, Magdalena Moneva-Léniz, Celia Sanchis-Sánchez, Almudena Mateu-Puchades
Dear Editor, Gestational pemphigoid (GP) is a rare autoimmune bullous dermatosis in pregnancy. GP usually occurs during the second or third month of pregnancy. It clinically manifests as the development of either early-onset urticarial lesions or late-onset subepidermal blisters that may linger for weeks or even months. Herein we report the case of a 45-year-old woman with the distinctive clinical onset of GP. A forty-five-year-old woman, gravida I, para 0, at 27 weeks gestation, was referred for evaluation to our Department with an extensive pruritic eruption that had developed over the previous 7 days...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29782305/tatami-mats-a-source-of-pitted-keratolysis-in-a-martial-arts-athlete
#12
Anamaria Balić, Zrinka Bukvić Mokos, Branka Marinović, Daniela Ledić Drvar
Dear Editor, Pitted keratolysis (PK), also known as keratosis plantaris sulcatum, is a non-inflammatory, bacterial, superficial cutaneous infection, characterized by many discrete superficial crateriform ''pits'' and erosions in the thickly keratinized skin of the weight-bearing regions of the soles of the feet (1). The disease often goes unnoticed by the patient, but when it is noticed it is because of the unbearable malodor and hyperhidrosis of the feet, which are socially unacceptable and cause great anxiety to many of the patients...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29782303/clindamycin-induced-maculopapular-exanthema-with-preferential-involvement-of-striae-distensae-a-koebner-phenomenon
#13
Benigno Monteagudo, Miguel Cabanillas, Pilar Iriarte, Aquilina Ramírez-Santos, Elvira León-Muinos, Daniel González-Vilas, Óscar Suárez-Amor
Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Cutaneous adverse reactions are usually maculopapular exanthemas, although hypersensitivity syndrome, acute generalized exanthematous pustulosis, and Stevens-Johnson syndrome have also been reported (1). We report the case of a patient with a maculopapular rash triggered by clindamycin who developed cutaneous lesions on striae distensae (SD). A 47-year-old woman was referred to our clinic for pruritic cutaneous lesions which had started 6 days earlier...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29782302/reasons-for-not-using-condoms-among-heterosexual-men-in-belgrade-serbia
#14
Milan Bjekić, Sandra Sipetić-Grujičić, Hristina Vlajinac, Aleksandra Nikolić
Dear Editor, Proper and consistent use of male condoms can be a highly effective method of preventing the transmission of sexually transmitted infections (STIs) and HIV (1), but this method relies on men's willingness and ability to use condoms. In the United States of America, about 20% overall and less than 50% of adults with multiple partners used a condom at last intercourse (2). In Serbia in 2013 (3), 50.0% of women and 62.5% of men aged 15-49 who had more than one partner in the past year used a condom during their last intercourse...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29782298/orthopedic-and-cutaneous-reactions-to-nickel-after-total-hip-replacement
#15
Domagoj Delimar, Ivan Bohaček, Zrinjka Paštar, Jasna Lipozenčić
Implant degradation products have shown signs of a cutaneous allergic response after implantation of a metal orthopedic replacement, loosening and failure of the joints as well as skin rashes, general fatigue, pain, and impaired wounds and bone healing. The prevalence of contact skin sensitivity in patients with a joint replacement device is higher than that in the general population. This delayed hypersensitivity to metallic orthopedic implants is more clearly defined and is a contributing factor to implant failure...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29781672/immunological-response-to-brucella-abortus-strain-19-vaccination-of-cattle-in-a-communal-area-in-south-africa
#16
Gregory J G Simpson, Tanguy Marcotty, Elodie Rouille, Abel Chilundo, Jean-Jacques Letteson, Jacques Godfroid
Brucellosis is of worldwide economic and public health importance. Heifer vaccination with live attenuated Brucella abortus strain 19 (S19) is the cornerstone of control in low- and middle-income countries. Antibody persistence induced by S19 is directly correlated with the number of colony-forming units (CFU) per dose. There are two vaccination methods: a 'high' dose (5-8 × 1010 CFU) subcutaneously injected or one or two 'low' doses (5 × 109 CFU) through the conjunctival route. This study aimed to evaluate serological reactions to the 'high' dose and possible implications of the serological findings on disease control...
March 29, 2018: Journal of the South African Veterinary Association
https://www.readbyqxmd.com/read/29781547/altered-expression-of-matrix-remodeling-associated-7-mxra7-in-psoriatic-epidermis-evidence-for-a-protective-role-in-the-psoriasis-imiquimod-mouse-model
#17
Jinling Ning, Ying Shen, Ting Wang, Mengru Wang, Wei Liu, Yonghu Sun, Furen Zhang, Lingling Chen, Yiqiang Wang
Preliminary datamining performed with Gene Expression Omnibus datasets implied that psoriasis may involve the matrix remodeling associated 7 (MXRA7), a gene with little function information yet. To test that hypothesis, studies were performed in human samples and murine models. Immunohistochemistry in normal human skin showed that MXRA7 proteins were present across the full epidermal layer, with highest expression level detected in the basal layer. In psoriatic samples, MXRA7 proteins were absent in the basal stem cells layer while suprabasal keratinocytes stained at a higher level than in normal tissues...
May 21, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29781542/diversity-of-staphylococcus-pseudintermedius-in-carriage-sites-and-skin-lesions-of-dogs-with-superficial-bacterial-folliculitis-potential-implications-for-diagnostic-testing-and-therapy
#18
Rikke Friis Larsen, Lene Boysen, Lisbeth Rem Jessen, Luca Guardabassi, Peter Damborg
BACKGROUND: Staphylococcus pseudintermedius is genotypically diverse within the canine population and multiple strains may colonize individual dogs at any given time. If multiple strains with distinct antimicrobial resistance profiles are present in superficial bacterial folliculitis (SBF), sampling a single skin lesion for culture and antimicrobial susceptibility testing (AST) might be inadequate to select effective therapy. HYPOTHESIS/OBJECTIVES: To investigate S...
May 21, 2018: Veterinary Dermatology
https://www.readbyqxmd.com/read/29781249/prevalence-and-risk-factors-for-injection-site-skin-infections-among-people-who-inject-drugs-pwid-in-tehran
#19
Mehdi Noroozi, Bahram Armoon, Hesam Ghisvand, Alireza Noroozi, Mahmood Karimy, Mohammad Rafi Bazrafshan, Brandon D L Marshall, Bahman Dieji
BACKGROUND/OBJECTIVES: Injection drug use is one of the major public health problems in Iran. Injection drug use is associated with numerous negative health outcomes, such as blood-borne infections (HIV, HCV) and injection site skin infections (abscesses, cellulitis). The aim of this study was to determine prevalence of injection site skin infections and its associated risk factors among people who inject drugs (PWID) in Tehran, Iran. METHODS: The cross-sectional study was conducted from March to August 2016 in Tehran province...
May 20, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29780832/collagen-type-iii-metabolism-evaluation-in-patients-with-malignant-head-and-neck-cancer-treated-with-radiotherapy
#20
Klaudia Mazurek, Krzysztof Siemianowicz, Wirginia Likus, Ewa Pierzchała, Robert Kwiatkowski, Jarosław Markowski
Ionizing radiation affects the metabolism of key proteins of extracellular matrix including type III collagen, an important component of human skin. The aim of the work is an analysis of the impact of radical and palliative radiotherapy on collagen type III synthesis in patients with head and neck cancer. The test group consisted of 56 males with histopathologically confirmed head and neck cancer, for whom radiotherapy was applied as a form of radical or palliative treatment. The level of procollagen III aminoterminal propeptide (PIIINP), which is a marker of collagen type III synthesis, was determined in blood serum before radiotherapy, immediately following radiotherapy, and 3 months after it was finished...
2018: BioMed Research International
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