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https://www.readbyqxmd.com/read/28817649/point-of-care-wound-visioning-technology-reproducibility-and-accuracy-of-a-wound-measurement-app
#1
Sheila C Wang, John A E Anderson, Robyn Evans, Kevin Woo, Benjamin Beland, Denis Sasseville, Linda Moreau
BACKGROUND: Current wound assessment practices are lacking on several measures. For example, the most common method for measuring wound size is using a ruler, which has been demonstrated to be crude and inaccurate. An increase in periwound temperature is a classic sign of infection but skin temperature is not always measured during wound assessments. To address this, we have developed a smartphone application that enables non-contact wound surface area and temperature measurements. Here we evaluate the inter-rater reliability and accuracy of this novel point-of-care wound assessment tool...
2017: PloS One
https://www.readbyqxmd.com/read/28816740/the-value-of-direct-immunofluorescence-on-proteinase-digested-formalin-fixed-paraffin-embedded-skin-biopsies
#2
Aida Valencia-Guerrero, April Deng, Karen Dresser, Gail Bouliane, Kristine M Cornejo
Direct immunofluorescence (DIF) on frozen tissue (DIF-F) is the method of choice for the identification of immune deposits present in skin and other tissues. DIF can also be performed on formalin-fixed paraffin-embedded tissue (DIF-P) after antigen retrieval with proteases and has proven to be of value in renal pathology. However, its utility in skin biopsies has not been fully examined. In this study, we performed DIF-P on 60 skin biopsies that comprised of bullous pemphigoid (n = 18), pemphigoid gestationis (n = 1), pemphigus (n = 7), linear IgA disease (n = 7), vasculitis (n = 20), lupus erythematosus (n = 3), and dermatitis herpetiformis (n = 4) cases...
August 9, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28815599/the-reduction-of-intraepidermal-p2x3-nerve-fiber-density-correlates-with-behavioral-hyperalgesia-in-a-rat-model-of-nerve-injury-induced-pain
#3
Malik Bechakra, Barthold N Schüttenhelm, Tiziana Pederzani, Pieter A van Doorn, Chris I de Zeeuw, Joost L M Jongen
Skin biopsies from patients with neuropathic pain often show changes in epidermal innervation, although it remains to be elucidated to what extent such changes can be linked to a particular subgroup of nerve fibers and how these changes are correlated with pain intensity. Here, we investigated to what extent behavioral signs of hyperalgesia are correlated with immunohistochemical changes of peptidergic and non-peptidergic epidermal nerve fibers in a rat model of nerve injury-induced pain. Rats subjected to unilateral partial ligation of the sciatic nerve developed significant mechanical and thermal hyperalgesia as tested by the withdrawal responses of the ipsilateral footpad to von Frey hairs and hotplate stimulation...
August 17, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28815351/an-integrated-model-of-skin-cancer-risk-in-sexual-minority-males
#4
Aaron J Blashill, Benjamin M Rooney, Kristen J Wells
Sexual minority males are an at-risk group for developing skin cancer. Elevated rates of skin cancer among this population are thought to be driven by excess indoor tanning; however, motivations to indoor tan among this population are unknown. Theoretically, appearance-based and affect regulation motives may be proximal predictors of increased indoor tanning in this population. The current study tests an integrated biopsychosocial model of indoor tanning behaviors and future intentions among a sample of sexual minority males...
August 16, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28815269/enhanced-conscious-processing-and-blindsight-like-detection-of-fear-conditioned-stimuli-under-continuous-flash-suppression
#5
Joana B Vieira, Sophia Wen, Lindsay D Oliver, Derek G V Mitchell
Emotional information, and specifically fear-related stimuli, have been shown to be preferentially processed at a nonconscious level and gain privileged access to awareness. However, recent evidence has emerged suggesting these findings are explained by low-level visual features rather than emotional salience. In this study, we tested the hypothesis that emotional salience increases both blindsight (i.e., detection with reduced awareness) and awareness of visually suppressed stimuli. We used fear conditioning to manipulate the emotional significance of neutral expressions presented under Continuous Flash Suppression...
August 16, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28815010/development-and-characterisation-of-a-low-concentration-sodium-dodecyl-sulphate-decellularised-porcine-dermis
#6
Jack A Helliwell, Daniel S Thomas, Vaia Papathanasiou, Shervanthi Homer-Vanniasinkam, Amisha Desai, Louise M Jennings, Paul Rooney, John N Kearney, Eileen Ingham
The aim of this study was to adapt a proprietary decellularisation process for human dermis for use with porcine skin. Porcine skin was subject to: sodium chloride (1 M) to detach the epidermis, trypsin paste to remove hair follicles, peracetic acid (0.1% v/v) disinfection, washed in hypotonic buffer and 0.1% (w/v) sodium dodecyl sulphate in the presence of proteinase inhibitors followed by nuclease treatment. Cellular porcine skin, decellularised porcine and human dermis were compared using histology, immunohistochemistry, GSL-1 lectin (alpha-gal epitope) staining, biochemical assays, uniaxial tensile and in vitro cytotoxicity tests...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28814926/wuchereria-bancrofti-infection-at-four-primary-schools-and-surrounding-communities-with-no-previous-blood-surveys-in-northern-uganda-the-prevalence-after-mass-drug-administrations-and-a-report-on-suspected-non-filarial-endemic-elephantiasis
#7
Emmanuel Igwaro Odongo-Aginya, Alex Olia, Kilama Justin Luwa, Eiji Nagayasu, Anna Mary Auma, Geoffrey Egitat, Gerald Mwesigwa, Yoshitaka Ogino, Eisaku Kimura, Toshihiro Horii
BACKGROUND: A prevalence study of Wuchereria bancrofti infection was carried out in 2014 at 4 study sites in northern Uganda using antigen and microfilaria tests. Each study site consists of a primary school and surrounding communities. These sites are inside the filariasis endemic area and have been covered by mass drug administration under the national elimination programme. However, no prevalence study had been conducted there before the present study. Without information on past and present endemicity levels, our study was meant to be an independent third-party investigation to know the latest filariasis situation...
2017: Tropical Medicine and Health
https://www.readbyqxmd.com/read/28814768/risk-factors-for-radiation-induced-skin-ulceration-in-percutaneous-coronary-interventions-of-chronic-total-occluded-lesions-a-2-year-observational-study
#8
Chi-Cheng Lai, Kai-Che Wei, Wen-Yee Chen, Guang-Yuan Mar, Wen-Hwa Wang, Chieh-Shan Wu, Ching-Jiunn Tseng, Kuo-Chung Yang, Lee-Wei Chen, Chun-Peng Liu
Relationship between radiation-induced skin ulceration (RSU) and variables in percutaneous coronary interventions (PCI) was rarely reported. RSU is a severe complication in PCIs, especially for chronic total occlusion (CTO) lesions. We investigated the RSUs and their risk factors in patients receiving CTO PCIs over a 2-year period. Data were analyzed using chi-square tests, t-tests and receiver operating characteristic (ROC) curve. Of 238 patients, 11 patients (4.6%) had RSUs all at right upper back. RSUs were significantly associated with use of left anterior oblique (LAO) views (100% vs...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28814545/metabolic-differentiation-of-early-lyme-disease-from-southern-tick-associated-rash-illness-stari
#9
Claudia R Molins, Laura V Ashton, Gary P Wormser, Barbara G Andre, Ann M Hess, Mark J Delorey, Mark A Pilgard, Barbara J Johnson, Kristofor Webb, M Nurul Islam, Adoracion Pegalajar-Jurado, Irida Molla, Mollie W Jewett, John T Belisle
Lyme disease, the most commonly reported vector-borne disease in the United States, results from infection with Borrelia burgdorferi. Early clinical diagnosis of this disease is largely based on the presence of an erythematous skin lesion for individuals in high-risk regions. This, however, can be confused with other illnesses including southern tick-associated rash illness (STARI), an illness that lacks a defined etiological agent or laboratory diagnostic test, and is coprevalent with Lyme disease in portions of the eastern United States...
August 16, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28814360/skin-rash-in-a-2-week-old-infant
#10
Marjan Nassiri, Sami L Bahna
We presented a case of a male infant with annular patchy rash on his torso since 2 weeks of age. This was initially diagnosed as tinea corporis but did not respond to oral antifungal treatment. Because of the appearance of the rash and a history of a certain disease in a maternal aunt, we suspected the most probable cause of the rash and the diagnosis was confirmed by laboratory testing. Furthermore, laboratory screening of the mother, who was asymptomatic, revealed that she was seropositive for the disease and was counseled on the importance of follow-up...
September 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28814358/frequency-of-selective-immediate-responders-to-aminopenicillins-and-cephalosporins-in-turkish-children
#11
Emine Dibek Misirlioglu, Hakan Guvenir, Muge Toyran, Emine Vezir, Murat Capanoglu, Ersoy Civelek, Betul Buyuktiryaki, Tayfur Ginis, Can Naci Kocabas
BACKGROUND: Beta-lactam antibiotics (BLA) are the most commonly prescribed antibiotics and are responsible for the majority of immediate hypersensitivity reactions to drugs in children. Cross-reactivity is important in hypersensitivity to BLAs because these drugs all share a common beta-lactam structure and some share similar side chains. OBJECTIVE: The aim of this study was to evaluate the clinical characteristics of patients who are diagnosed with immediate-type BLA hypersensitivity and frequency of patients with side chain hypersensitivity, "selective responders...
September 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28814357/association-of-aeroallergen-sensitization-and-atopic-disease-in-the-sonoran-desert
#12
Ryan D Buckley, Tara F Carr
BACKGROUND: Numerous aeroallergens have been associated with the development of asthma, including Alternaria, house-dust mite, and pet dander. Tucson, Arizona, is located in the Sonoran Desert, which has the highest diversity of vegetation of any desert in the world. Given the unique pollen profile in this region, we sought to identify the most common aeroallergens associated with rhinitis and asthma diagnosis in the local adult population. OBJECTIVE: To identify the prevalence of aeroallergen sensitivity in the Tucson adult population and to identify which aeroallergens are associated with a diagnosis of asthma...
September 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28814355/der-p-1-and-der-p-2-specific-immunoglobulin-e-measurement-for-diagnosis-of-dermatophagoides-pteronyssinus-allergy-a-systematic-review-and-meta-analysis
#13
Man Tian, Ying Zhou, Wenxin Zhang, Yubao Cui
BACKGROUND: A clinical history of allergic symptoms and a skin-prick test with house-dust mite crude extracts are standard diagnostic procedures for Dermatophagoides pteronyssinus allergy. Specific immunoglobulin E (IgE) responses to Der p 1 and Der p 2 allergens have been used for the diagnosis of D. pteronyssinus allergy; however, evaluation of the diagnostic performance of Der p 1 and Der p 2 specific IgE (sIgE) produced inconsistent findings. We sought to evaluate the diagnostic accuracy of Der p 1 sIgE and Der p 2 sIgE measurement in the diagnosis of D...
September 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28814352/characteristics-of-drug-induced-anaphylaxis-in-children-and-adolescents
#14
Ozlem Cavkaytar, Betül Karaatmaca, Pınar Gur Cetinkaya, Saliha Esenboga, Ebru Arik Yilmaz, Umit M Sahiner, Bulent E Sekerel, Ozge Soyer
BACKGROUND: Although data on anaphylaxis in the general population exist for different allergens, there is still lack of detailed etiologic data on drug-induced anaphylaxis (DIA), particularly in children. OBJECTIVE: To define the etiology of DIA, to determine the accuracy of drug-related anaphylaxis histories, along with the severity and culprit drug associations among individuals <18 years old. METHODS: Patients with a history of drug hypersensitivity reaction (DHR) referred to our center between January 2012 and February 2016 were included...
September 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28813999/upper-limb-prosthetic-control-using-wearable-multichannel-mechanomyography
#15
Samuel Wilson, Ravi Vaidyanathan
In this paper we introduce a robust multi-channel wearable sensor system for capturing user intent to control robotic hands. The interface is based on a fusion of inertial measurement and mechanomyography (MMG), which measures the vibrations of muscle fibres during motion. MMG is immune to issues such as sweat, skin impedance, and the need for a reference signal that is common to electromyography (EMG). The main contributions of this work are: 1) the hardware design of a fused inertial and MMG measurement system that can be worn on the arm, 2) a unified algorithm for detection, segmentation, and classification of muscle movement corresponding to hand gestures, and 3) experiments demonstrating the real-time control of a commercial prosthetic hand (Bebionic Version 2)...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813842/using-wearable-physiological-sensors-to-predict-energy-expenditure
#16
Kimberly A Ingraham, Daniel P Ferris, C David Remy
Lower-limb assistive robotic devices are often evaluated by measuring a reduction in the user's energy cost. Using indirect calorimetry to estimate energy cost is poorly suited for real-time estimation and long-term collection. The goal of this study was to use data from wearable sensors to predict energy cost with better temporal resolution and less variability than breath measurements. We collected physiological data (heart rate, electrodermal activity, skin temperature) and mechanical data (EMG, accelerometry) from three healthy subjects walking on a treadmill at various speeds on level ground, inclined, and backwards...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28812936/investigation-of-goldmann-perimetry-in-evaluation-of-patients-for-upper-eyelid-blepharoplasty
#17
John D Pemberton, Michael Salter, Aaron Fay, Bradley Thuro, Horace Spencer, Omar Dajani
PURPOSE: To determine if preoperative Goldmann Visual Field (GVF) testing in patients with functional dermatochalasis accurately depicts the postoperative superior visual field (SVF) outcome. METHODS: A prospective cohort study was done to compare preoperative and postoperative GVF field tests in patients undergoing upper eyelid blepharoplasty for treatment of dermatochalasis. This study was conducted in accordance with the Declaration of Helsinki and approved by the University of Arkansas for Medical Sciences institutional review board...
August 16, 2017: Orbit
https://www.readbyqxmd.com/read/28812776/labelled-sunscreen-spfs-may-overestimate-protection-in-natural-sunlight
#18
Brian Diffey, Uli Osterwalder
Limited evidence exists to indicate that sunscreen protection factors determined in the laboratory are higher than those in natural sunlight. In this article we propose an explanation for this difference and estimate the expected SPFs of sunscreen products in natural sunlight and those expected from laboratory testing. Our results indicate that the labelled SPF, determined by in vivo assay using a UV solar simulator, overestimates the SPF that would be expected in natural sunlight to the extent that for products labelled SPF50+, it may not be possible to achieve a protection against sunlight of more than 25-fold...
August 16, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28812281/preclinical-development-of-an-automated-injection-device-for-intradermal-delivery-of-a-cell-based-therapy
#19
Giulia Leoni, Alex Lyness, Patrick Ginty, Rindi Schutte, Gopalan Pillai, Gayatri Sharma, Paul Kemp, Natalie Mount, Michaela Sharpe
Current methods for intradermal delivery of therapeutic products in clinical use include manual injection via the Mantoux technique and the use of injection devices, primarily developed for the delivery of vaccines and small molecules. A novel automated injection device is presented specifically designed for accurate delivery of multiple doses of product through a number of adjustable injection parameters, including injection depth, dose volume and needle insertion speed. The device was originally conceived for the delivery of a cell-based therapy to patients with skin wounds caused by epidermolysis bullosa...
August 15, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28811007/acceleration-of-skin-wound-healing-by-low-dose-indirect-ionizing-radiation-in-male-rats
#20
Nasrollah Jabbari, Gholam Hossein Farjah, Behnam Ghadimi, Hajar Zanjani, Behnam Heshmatian
A recent hypothesis has revealed that low-dose irradiation (LDI) with ionizing radiation might have a promoting effect on fracture healing. The aim of this study was to investigate the influence of direct (electron beam) and indirect (gamma-ray) low-dose ionizing irradiations on the wound healing process in male rats. In 72 male rats, a full-thickness wound was incised. The animals were randomly assigned to three groups, each with 24 rats. The first two groups were named IG-I and IG-II and respectively exposed to electron and gamma-radiations (75 cGy) immediately after the surgical procedure...
August 2017: Kaohsiung Journal of Medical Sciences
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