keyword
https://read.qxmd.com/read/38441327/immune-modulation-by-nutritional-intervention-in-malnourished-children-identifying-the-phenotypic-distribution-and-functional-responses-of-peripheral-blood-mononuclear-cells
#21
JOURNAL ARTICLE
Zannatun Noor, Md Mehedi Hasan, Md Amran Gazi, Farzana Hossaini, Nur Muhammad Shahedul Haque, Parag Palit, Shah Mohammad Fahim, Subhasish Das, Mustafa Mahfuz, Chelsea Marie, William A Petri, Rashidul Haque, Tahmeed Ahmed
Malnourished children are susceptible to an increased risk of mortality owing to impaired immune functions. However, the underlying mechanism of altered immune functions and its interaction with malnutrition is poorly understood. This study investigates the immune function and evaluates the effect of a particular nutritional intervention on the immune cells of undernourished children. Stunted (LAZ <-2) and at-risk of being stunted (length-for-age Z-scores, LAZ <-1 to -2) children aged between 12 and 18 months were enrolled and were provided with the daily nutritional intervention of one egg and 150 mL cow's milk for 90 days...
September 2023: Scandinavian Journal of Immunology
https://read.qxmd.com/read/38432554/safety-and-efficacy-not-guaranteed-separating-fact-from-fiction-regarding-extensively-heated-egg-and-milk-products
#22
EDITORIAL
Aikaterini Anagnostou, Matthew Greenhawt
No abstract text is available yet for this article.
February 17, 2024: Annals of Allergy, Asthma & Immunology
https://read.qxmd.com/read/38420126/food-specific-igg4-guided-diet-elimination-improves-allergy-symptoms-in-children
#23
JOURNAL ARTICLE
Boyun Yang, Hanxiao Yu, Wo Yao, Ran Diao, Bohui Li, Yongfang Wang, Ting Li, Liuya Ge, Yingying Hu, Huiying Wang
Allergic diseases in children are major public health concerns due to their widespread and rising prevalence. Food-specific immunoglobulin G4(FS-IgG4) has been detected in patients with allergic diseases, but its clinical significance is still debated. In the present study, 407 children with allergic diseases were recruited and categorized into three groups according to the different systems involved: the respiratory system group, the skin system group, and a multiple system group, with the collection of clinical symptoms and serum antibodies, including total immunoglobulin E (IgE), house dust mite (HDM) IgE, food-specific IgE (FS-IgE), and FS-IgG4...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38416390/the-natural-history-and-risk-factors-for-the-development-of-food-allergies-in-children-and-adults
#24
REVIEW
Eric C K Lee, Brit Trogen, Kathryn Brady, Lara S Ford, Julie Wang
PURPOSE OF REVIEW: This narrative review explores food allergy prevalence and natural history stratified by life stages, especially in context of evolving knowledge over the last few decades. RECENT FINDINGS: The prevalence of food allergy remains highest in early childhood with common food triggers being cow's milk, soy, hen's egg, wheat, peanut, tree nuts, sesame, fish, and shellfish. This correlates with certain risk factors especially pertinent in the postnatal period which appear to predispose an individual to developing a food allergy...
February 28, 2024: Current Allergy and Asthma Reports
https://read.qxmd.com/read/38415948/timing-of-initial-symptom-onset-during-milk-and-wheat-challenges-a-retrospective-study
#25
JOURNAL ARTICLE
Noriyuki Yanagida, Takanori Minoura, Sakura Sato, Kyohei Takahashi, Ken-Ichi Nagakura, Kiyotake Ogura, Takaaki Itonaga, Yoko Miura, Naoko Fusayasu, Motohiro Ebisawa
BACKGROUND: Allergic reactions to milk appear sooner than those to hen's eggs, irrespective of the total dose of the oral food challenges (OFCs) and type of matrices. The reported median times for the first symptom occurrence are 20-30 min with milk and 50-60 min with eggs. However, allergic reactions due to wheat have not yet been fully investigated. METHODS: This study retrospectively collected data from OFC for milk and wheat conducted at Sagamihara National Hospital and Sendai Medical Center from 2009 to 2023...
February 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38409718/development-and-evaluation-of-celecoxib-emulgel-by-using-natural-oil
#26
JOURNAL ARTICLE
Aarti Rajput, Rishabh Gaur, Mayank Kulshreshtha, Sumedha Singh Jadaun, Vibha Kumari
BACKGROUND: Emulgel combines the qualities of an emulsion with those of a gel. In order to create an emulgel w/o or o/w, emulsions have to be formulated, which are then combined with a gelling agent, resulting in a dual-control drug release. Celecoxib exhibits analgesic, antipyretic and anti-inflammatory activities and is used to treat osteoarthritis, severe pain, rheumatoid arthritis, and other medical conditions. METHODS: Celecoxib Emulgel was developed and evaluated by using natural oil and carbopol-940 as a gelling agent in different concentrations...
February 21, 2024: Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry
https://read.qxmd.com/read/38407394/omalizumab-for-the-treatment-of-multiple-food-allergies
#27
JOURNAL ARTICLE
Robert A Wood, Alkis Togias, Scott H Sicherer, Wayne G Shreffler, Edwin H Kim, Stacie M Jones, Donald Y M Leung, Brian P Vickery, J Andrew Bird, Jonathan M Spergel, Ahmar Iqbal, Julie Olsson, Monica Ligueros-Saylan, Alkaz Uddin, Agustin Calatroni, Charmaine Marquis Huckabee, Nicole H Rogers, Nancy Yovetich, Jennifer Dantzer, Kim Mudd, Julie Wang, Marion Groetch, David Pyle, Corinne A Keet, Michael Kulis, Sayantani B Sindher, Andrew Long, Amy M Scurlock, Bruce J Lanser, Tricia Lee, Christopher Parrish, Terri Brown-Whitehorn, Amanda K Rudman Spergel, Maria Veri, Sanaz Daneshfar Hamrah, Erica Brittain, Julian Poyser, Lisa M Wheatley, R Sharon Chinthrajah
BACKGROUND: Food allergies are common and are associated with substantial morbidity; the only approved treatment is oral immunotherapy for peanut allergy. METHODS: In this trial, we assessed whether omalizumab, a monoclonal anti-IgE antibody, would be effective and safe as monotherapy in patients with multiple food allergies. Persons 1 to 55 years of age who were allergic to peanuts and at least two other trial-specified foods (cashew, milk, egg, walnut, wheat, and hazelnut) were screened...
February 25, 2024: New England Journal of Medicine
https://read.qxmd.com/read/38390780/identification-of-duck-egg-vitellogenin-as-the-cause-of-selective-anaphylaxis-to-duck-egg
#28
JOURNAL ARTICLE
L Romero-Sánchez, T González-Fernández, B Bartolomé-Zavala, C Pastor-Vargas, V García-Paz, P Méndez-Brea
No abstract text is available yet for this article.
February 2024: Journal of Investigational Allergology & Clinical Immunology
https://read.qxmd.com/read/38374627/variation-in-the-allergenicity-of-scrambled-boiled-short-baked-and-long-baked-egg-white-proteins
#29
JOURNAL ARTICLE
Purevsan Gantulga, Jeongmin Lee, Kyunguk Jeong, Se-Ah Jeon, Sooyoung Lee
BACKGROUND: Hen's egg white (HEW) is the most common cause of food allergy in children which induces mild to fatal reactions. The consultation for a proper restriction is important in HEW allergy. We aimed to identify the changes in HEW allergenicity using diverse cooking methods commonly used in Korean dishes. METHODS: Crude extract of raw and 4 types of cooked HEW extracts were produced and used for sodium dodecyl-sulfate polyacrylamide gel electrophoresis (SDS-PAGE), enzyme-linked immunosorbent assay (ELISA), and ELISA inhibition assays using 45 serum samples from HEW allergic and tolerant children...
February 19, 2024: Journal of Korean Medical Science
https://read.qxmd.com/read/38349368/management-of-food-allergies-and-food-related-anaphylaxis
#30
JOURNAL ARTICLE
Edward G A Iglesia, Mildred Kwan, Yamini V Virkud, Onyinye I Iweala
IMPORTANCE: An estimated 7.6% of children and 10.8% of adults have IgE-mediated food-protein allergies in the US. IgE-mediated food allergies may cause anaphylaxis and death. A delayed, IgE-mediated allergic response to the food-carbohydrate galactose-α-1,3-galactose (alpha-gal) in mammalian meat affects an estimated 96 000 to 450 000 individuals in the US and is currently a leading cause of food-related anaphylaxis in adults. OBSERVATIONS: In the US, 9 foods account for more than 90% of IgE-mediated food allergies-crustacean shellfish, dairy, peanut, tree nuts, fin fish, egg, wheat, soy, and sesame...
February 13, 2024: JAMA
https://read.qxmd.com/read/38348623/why-is-pet-cat-dog-allergen-immunotherapy-ait-such-a-controversial-topic-current-perspectives-and-future-directions
#31
REVIEW
G Liccardi, M Martini, M B Bilò, L Cecchi, M Milanese, L Brussino, E Motta, P Rogliani
Dogs and cats are the most common pets worldwide. In Italy, the prevalence of allergic sensitization to cats and dogs is 16% and 9% respectively. The limited standardization of allergenic extracts, especially for dogs, emphasizes the importance of Component Resolved Diagnosis (CRD) for accurate diagnosis and subsequent prescription of allergen immunotherapy (AIT). However, this low standardization is the main factor contributing to the unsatisfactory clinical efficacy of traditional AIT, AIT with modified allergens, and intralymphatic allergen-specific immunotherapy (ILAIT)...
February 13, 2024: European Annals of Allergy and Clinical Immunology
https://read.qxmd.com/read/38338542/comprehensive-epitope-analysis-of-monoclonal-antibodies-binding-to-hen-egg-ovalbumin-using-a-peptide-array
#32
JOURNAL ARTICLE
Yuko Terada, Masanobu Akimoto, Hirofumi Sakoda, Shunsuke Yamamoto, Mayuka Kubota, Tomoharu Motoyama, Yo Imanaka, Shogo Nakano, Sohei Ito, Shigeki Kato, Keisuke Ito
Food allergies are a significant health issue worldwide. In many countries, labeling of primary allergens in food products has been made mandatory to ensure consumer safety. In food manufacturing settings, the lateral flow immunoassay (LFI)-based on antigen-antibody reactions-is a rapid and accurate method for allergen testing and is widely used. Peptide arrays are tools that enable the synthesis of peptides of any sequence on a substrate and high-throughput analysis of their interactions with chemicals. This study aimed to investigate a new application of peptide arrays in the field of food technology, particularly in the development of antibodies for food allergen testing...
January 26, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38336145/age-specific-metabolomic-profiles-in-children-with-food-allergy
#33
JOURNAL ARTICLE
E Crestani, M Benamar, W Phipatanakul, R Rachid, T A Chatila
BACKGROUND: Food allergy (FA) in young children is often associated with eczema, frequently directed to egg/cow milk allergens and has a higher chance of resolution, while FA that persists in older children has less chance of resolution and is less clearly associated with atopy. METHODS: Children with FA (n = 62) and healthy controls (n = 28) were categorized into "younger" (≤5 years) and "older" (>5 years). Mass spectrometry-based untargeted metabolomic profiling as wells as cytokine profiling were performed on plasma samples in FA children in each age group...
February 7, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38325554/antibiotic-residues-in-foods-of-animal-origin-in-cameroon-prevalence-consumers-risk-perceptions-and-attitudes
#34
JOURNAL ARTICLE
Mohamed Moctar Mouliom Mouiche, Ndode Herman Okah-Nnane, Frédéric Moffo, Ibrahima Djibo, Nabilah Pemi Mapiefou, Serge Eugene Mpouam, Youssouf Mouliom Mfopit, Jean-Pierre Kilekoung Mingoas, Stanly Fon Tebug, Julius Awah Ndukum
The use of antibiotics in food animals and the non-observance of the withdrawal period might result in the accumulation and persistence of residues in foods. The contamination of foods by antibiotic residues might induce health risks including allergy, gastrointestinal dysbiosis, antimicrobial resistance and cancer to consumers. Therefore, this study was initiated to investigate the presence of antibiotic residues in raw eggs, raw milk and beef collected at the wholesale and retail points in the three major cities of Cameroon and consumers perceptions of the risk of antibiotic residues in foods...
February 5, 2024: Journal of Food Protection
https://read.qxmd.com/read/38284922/serum-procalcitonin-levels-elevate-in-association-with-egg-yolk-associated-fpies-reaction
#35
JOURNAL ARTICLE
Yuka Okura, Masaki Shimomura, Yutaka Takahashi, Ichiro Kobayashi
No abstract text is available yet for this article.
January 2024: Pediatric Allergy and Immunology
https://read.qxmd.com/read/38284919/epigenomic-and-epigenetic-investigations-of-food-allergy
#36
REVIEW
Yoojin Chun, Jo Hsuan Lee, Supinda Bunyavanich
As a potential link between genetic predisposition, environmental exposures, and food allergy outcomes, epigenetics has been a molecular variable of interest in ongoing efforts to understand food allergy mechanisms and outcomes. Here we review population-based investigations of epigenetic loci associated with food allergy, focusing on established clinical food allergy. We first provide an overview of epigenetic mechanisms that have been studied in cohorts with food allergy, predominantly DNA methylation but also microRNA...
January 2024: Pediatric Allergy and Immunology
https://read.qxmd.com/read/38269609/parental-stress-and-food-allergy-phenotypes-in-young-children-a-national-birth-cohort-jecs
#37
JOURNAL ARTICLE
Kiwako Yamamoto-Hanada, Kyongsun Pak, Shintaro Iwamoto, Mizuho Konishi, Mayako Saito-Abe, Miori Sato, Yumiko Miyaji, Hidetoshi Mezawa, Minaho Nishizato, Limin Yang, Natsuhiko Kumasaka, Yukihiro Ohya
BACKGROUND: Food allergy children and their families tend to have emotional distress and anxiety. There have been few reports of differences in parenting stress and a child's food allergy phenotypes. METHODS: We examined the associations between food allergy phenotypes in children and parenting stress assessed by the Parenting Stress Index-Short Form (PSI-SF) from a national birth cohort (Japan Environment and Children's Study). RESULTS: We included 65,805 children for statistical analysis...
January 25, 2024: Allergy
https://read.qxmd.com/read/38263695/evaluation-of-clinical-outcomes-of-efficacy-in-food-allergen-immunotherapy-trials-cofaith-eaaci-task-force
#38
JOURNAL ARTICLE
Pablo Rodríguez Del Río, Montserrat Álvaro-Lozano, Stefania Arasi, Raphaëlle Bazire, Carmelo Escudero, Nandinee Patel, Monica Sandoval-Ruballos, Marta Vazquez-Ortiz, Anna Nowak-Wegrzyn, Katharina Blümchen, Audrey Dunn Galvin, Antoine Deschildre, Matthew Greenhawt, Sabine Schnadt, Carmen Riggioni, Benjamin C Remington, Paul Turner, Montserrat Fernandez Rivas
Food allergy is a global public health problem that until recent years lacked any aetiological treatment supported by academy, industry and regulators. Food immunotherapy (AIT) is an evolving treatment option, supported by clinical practice and industry trial data. Recent AIT meta-analyses have highlighted the difficulty in pooling safety and efficacy data from AIT trials, due to secondary heterogeneity in the study. An EAACI task force (CO-FAITH) initiated by the Paediatric Section was created to focus on AIT efficacy outcomes for milk, egg and peanut allergy rather than in trial results...
January 23, 2024: Allergy
https://read.qxmd.com/read/38262763/vaccination-and-egg-allergy-considerations-for-family-physicians
#39
JOURNAL ARTICLE
Elissa M Abrams, Joseline G Zafack, Christina Jensen, Julie A Bettinger, Karina A Top, Kyla J Hildebrand, Matthew C Tunis
No abstract text is available yet for this article.
January 2024: Canadian Family Physician Médecin de Famille Canadien
https://read.qxmd.com/read/38257190/probiotics-in-infancy-and-childhood-for-food-allergy-prevention-and-treatment
#40
REVIEW
Margherita Di Costanzo, Adriana Vella, Claudia Infantino, Riccardo Morini, Simone Bruni, Susanna Esposito, Giacomo Biasucci
Food allergy represents a failure of oral tolerance mechanisms to dietary antigens. Over the past few years, food allergies have become a growing public health problem worldwide. Gut microbiota is believed to have a significant impact on oral tolerance to food antigens and in initiation and maintenance of food allergies. Therefore, probiotics have also been proposed in this field as a possible strategy for modulating both the gut microbiota and the immune system. In recent years, results from preclinical and clinical studies suggest a promising role for probiotics in food allergy prevention and treatment...
January 18, 2024: Nutrients
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