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https://www.readbyqxmd.com/read/27896827/leaping-through-the-looking-glass-secondary-analysis-of-the-effect-of-skin-test-size-and-age-of-introduction-on-peanut-tolerance-after-early-peanut-introduction
#1
Matthew Greenhawt, David Fleischer, Edmond S Chan, Carina Venter, David Stukus, Ruchi Gupta, Jonathan Spergel
BACKGROUND: In the Learning Early About Peanut Allergy (LEAP) study, early peanut introduction in high-risk 4-11 month olds was associated with a significantly decreased risk of developing peanut allergy. However, the influences of key baseline high-risk factors on peanut tolerance are poorly understood. METHODS: Secondary analysis was conducted on the publically available LEAP dataset, exploring relationships between peanut tolerance, baseline peanut/egg sensitization, eczema severity/duration, age of introduction, gender, and race...
November 29, 2016: Allergy
https://www.readbyqxmd.com/read/27859574/reintroduction-failure-is-common-among-adolescents-after-double-blind-placebo-controlled-food-challenges
#2
Å Strinnholm, A Winberg, L Hedman, E Rönmark, V Lindh
AIM: There has been a lack of research on adolescents' who undergo double-blind placebo-controlled food challenges. The aim of this study was to investigate food allergic adolescents' experiences and consequences of double-blind placebo-controlled food challenges. METHODS: This qualitative, descriptive interview study included 17 adolescents aged 14-15 years with total elimination of cows' milk, hens' eggs or cod due to food allergies. The participants, who were initially identified from a large population-based cohort study, were interviewed 18 months after completing their challenges...
November 12, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27803880/the-ingestion-of-cow-s-milk-formula-in-the-first-3-months-of-life-prevents-the-development-of-cow-s-milk-allergy
#3
Tetsuhiro Sakihara, Shiro Sugiura, Komei Ito
BACKGROUND: IgE-mediated cow's milk allergy (CMA) is one of the most common food allergies in infants. It is still controversial whether the early introduction of cow's milk formula (CMF) prevents the development of CMA. OBJECTIVE: We aimed to evaluate the duration and frequency of CMF ingestion as compere with exclusive breast-fed for preventing CMA in high-risk infants. METHODS: We enrolled the patients diagnosed with hen's egg allergy by an oral food challenge...
October 2016: Asia Pacific Allergy
https://www.readbyqxmd.com/read/27799959/predictors-of-allergen-sensitization-in-singapore-children-from-birth-to-3%C3%A2-years
#4
Evelyn Xiu Ling Loo, Jordan Zheng Ting Sim, Anne Goh, Oon Hoe Teoh, Yiong Huak Chan, Seang Mei Saw, Kenneth Kwek, Peter D Gluckman, Keith M Godfrey, Hugo Van Bever, Yap Seng Chong, Bee Wah Lee, Michael S Kramer, Lynette Pei-Chi Shek
BACKGROUND: Immune responses in allergic diseases begin with allergen sensitization, which usually occurs in childhood. Allergen sensitization involves a complex interplay of genetic and environmental factors, and sensitization patterns may change with age. OBJECTIVE: To determine the predictors of allergen sensitization in the first 3 years of life in the growing up in Singapore towards healthy outcomes (GUSTO) prospective birth cohort study. METHODS: Interviewers collected information on demographics, family history of allergy, social and lifestyle factors, and the child's health...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27799957/prospective-evaluation-of-testing-with-baked-milk-to-predict-safe-ingestion-of-baked-milk-in-unheated-milk-allergic-children
#5
Allison Kwan, Maria Asper, Sasson Lavi, Elana Lavine, David Hummel, Julia E Upton
BACKGROUND: Cow's milk allergy is one of the most common food allergies affecting young children. A subset of milk-allergic individuals can eat baked milk without allergic symptoms which is beneficial in terms of prognostication and liberalization of the diet. A retrospective study suggested that skin prick testing (SPT) with a baked milk (muffin) slurry may provide a sensitive means of predicting the outcome of a medically supervised baked milk oral food challenge. We evaluated the predictive value of SPT with baked milk to identify unheated milk-allergic children who are able to safely eat baked milk...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27788149/transcriptional-profiling-of-egg-allergy-and-relationship-to-disease-phenotype
#6
Roman Kosoy, Charuta Agashe, Alexander Grishin, Donald Y Leung, Robert A Wood, Scott H Sicherer, Stacie M Jones, A Wesley Burks, Wendy F Davidson, Robert W Lindblad, Peter Dawson, Miriam Merad, Brian A Kidd, Joel T Dudley, Hugh A Sampson, M Cecilia Berin
BACKGROUND: Egg allergy is one of the most common food allergies of childhood. There is a lack of information on the immunologic basis of egg allergy beyond the role of IgE. OBJECTIVE: To use transcriptional profiling as a novel approach to uncover immunologic processes associated with different phenotypes of egg allergy. METHODS: Peripheral blood mononuclear cells (PBMCs) were obtained from egg-allergic children who were defined as reactive (BER) or tolerant (BET) to baked egg, and from food allergic controls (AC) who were egg non-allergic...
2016: PloS One
https://www.readbyqxmd.com/read/27777641/heated-egg-yolk-challenge-predicts-the-natural-course-of-hen-s-egg-allergy-a-retrospective-study
#7
Yu Okada, Noriyuki Yanagida, Sakura Sato, Motohiro Ebisawa
BACKGROUND: Children do not always outgrow hen's egg allergies in early childhood. Because egg yolks are less allergenic than egg whites, we performed an oral food challenge with heated egg yolk slightly contaminated with egg white (EYSEW OFC) in infants allergic to hen's egg. We hypothesized that the EYSEW OFC results would predict the egg allergy's natural course. METHODS: We retrospectively reviewed participants with hen's egg allergy who underwent their first EYSEW OFC at 12-23 months of age between 2004 and 2010...
2016: World Allergy Organization Journal
https://www.readbyqxmd.com/read/27770112/measles-mumps-rubella-vaccine-for-children-with-egg-allergy-is-admission-for-inpatient-vaccination-necessary
#8
M S Tan, E J Teoh, C P Hor, A A C Yeoh
INTRODUCTION: Children who develop any hypersensitivity reaction to eggs are routinely referred to hospital for Measles-Mumps-Rubella (MMR) vaccination as inpatients to prevent anaphylaxis. We aimed to study the association between hypersensitivity reactions after egg exposure and similar reactions after MMR immunisation; and examine the necessity of hospital admission for vaccination. METHODS: A prospective observational study was conducted in Paediatric Department in Bukit Mertajam Hospital, Penang, between March and December 2014...
August 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/27747886/high-intensity-ultrasound-enhances-the-igg-and-ige-binding-of-ovalbumin
#9
Wen-Hua Yang, Zong-Cai Tu, Hui Wang, Xue Li, Ming Tian
BACKGROUND: Hen's egg is widely used in food industry due to its excellent nutritional and processing properties, and Ovalbumin (OVA) is the major allergen of hen's egg white. Ultrasound has been widely used in food processing industry, but effect of high intensity ultrasound on the immunoglobulin G (IgG) binding, immunoglobulin E (IgE) binding and conformational structure of OVA remains unclear. RESULTS: Ultrasound treatment at 600 - 800 W dramatically increased the IgG and IgE binding of OVA with the highest values observed at 600 W...
October 16, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27742394/a-randomized-trial-of-egg-introduction-from-4%C3%A2-months-of-age-in-infants-at-risk-for-egg-allergy
#10
John Wei-Liang Tan, Carolina Valerio, Elizabeth H Barnes, Paul J Turner, Peter A Van Asperen, Alyson M Kakakios, Dianne E Campbell
BACKGROUND: Epidemiologic evidence suggests delayed introduction of egg might not protect against egg allergy in infants at risk of allergic disease. OBJECTIVE: We sought to assess whether dietary introduction of egg between 4 and 6 months in infants at risk of allergy would reduce sensitization to egg. METHODS: We conducted a randomized controlled trial in infants with at least 1 first-degree relative with allergic disease. Infants with a skin prick test (SPT) response to egg white (EW) of less than 2 mm were randomized at age 4 months to receive whole-egg powder or placebo (rice powder) until 8 months of age, with all other dietary egg excluded...
October 11, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27733903/impaired-health-related-quality-of-life-in-adolescents-with-allergy-to-staple-foods
#11
Jennifer Lisa Penner Protudjer, Sven-Arne Jansson, Roelinde Middelveld, Eva Östblom, Sven-Erik Dahlén, Marianne Heibert Arnlind, Ulf Bengtsson, Ingrid Kallström-Bengtsson, Birgitta Marklund, Georgios Rentzos, Ann-Charlotte Sundqvist, Johanna Åkerström, Staffan Ahlstedt
BACKGROUND: Cow's milk, hen's egg and wheat are staple foods in a typical western diet. Despite the ubiquity of these foods, the impact of staple food allergy on health-related quality of life (HRQL) amongst adolescents is incompletely understood. The aims of this study were to make use of the Swedish version of EuroPrevall's disease-specific food allergy quality of life questionnaire-teenager form (FAQLQ-TF) and to investigate the association between objectively-diagnosed staple food allergy and HRQL amongst adolescents...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27717723/assessment-of-ige-mediated-food-allergies-in-children-with-atopic-dermatitis
#12
A Mavroudi, A Karagiannidou, I Xinias, D Cassimos, N Karantaglis, E Farmaki, G Imvrios, M Fotoulaki, M Eboriadou, J Tsanakas
BACKGROUND: Atopic dermatitis (AD) is an inflammatory disease of the skin, which is characterised by a chronic relapsing course. AIM: The aim of the study was to assign the prevalence of clinically active food allergies among a group of children between 3 months and 7 years of age, with AD. METHODS: Eighty-eight children with AD were screened for specific IgE antibodies to food proteins. All patients with AD and specific IgE antibodies to food proteins were subjected to Oral Food Challenges (OFCs) with the relevant foods...
October 4, 2016: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/27697703/dynamics-of-cytokine-mrna-expression-and-fecal-biomarkers-in-school-children-undergoing-a-double-blind-placebo-controlled-food-challenge-series
#13
Anna Winberg, Olga Nagaeva, Ivan Nagaev, Catarina Lundell, Ignacio Arencibia, Lucia Mincheva-Nilsson, Eva Rönmark, Christina E West
BACKGROUND: There is need for prognostic markers for symptomatic food allergy since current diagnostic methods are insufficient and/or time and labor consuming. OBJECTIVE: To estimate the cytokine mRNA profiles in peripheral blood mononuclear cells (PBMC) before and after a double-blind placebo-controlled food challenge series in schoolchildren with suspected allergy to milk, egg or cod and in healthy controls. Analyses of fecal inflammatory biomarkers before and after the challenge were included...
December 2016: Cytokine
https://www.readbyqxmd.com/read/27648271/egg-provoked-food-protein-induced-enterocolitis-like-syndrome-in-an-adult
#14
Celia Zubrinich, Mark Hew, Robyn O'Hehir
Food protein-induced enterocolitis syndrome is a non-IgE-mediated food allergy usually diagnosed in infancy. We report a case of a similar syndrome in an adult, following ingestion of egg. We remind clinicians to consider this diagnosis which may present to emergency physicians and gastroenterologists long before an allergist is consulted.
September 2016: Clinical Case Reports
https://www.readbyqxmd.com/read/27628022/the-use-of-omalizumab-in-food-oral-immunotherapy
#15
Roxane Labrosse, François Graham, Anne Des Roches, Philippe Bégin
Food allergy is an important health issue that affects up to 8 % of the population. The management of allergic patients involves allergen avoidance and prompts the treatment of accidental reactions, as no curative treatment is available so far in routine practice. Oral immunotherapy (OIT) is a promising therapeutic alternative, but it is associated with frequent allergic reactions and cost-effectiveness issues. In hopes of reducing such reactions, a number of trials have used omalizumab, an anti-IgE monoclonal humanized antibody, as adjunctive therapy in OIT...
September 14, 2016: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/27613459/influence-of-health-literacy-and-trust-in-online-information-on-food-allergy-quality-of-life-and-self-efficacy
#16
Nicholas Ditzler, Matthew Greenhawt
BACKGROUND: Health literacy among caregivers of food allergic individuals (FAIs) is poorly described, as are the information sources sought regarding food allergy. OBJECTIVE: To assess the association among health literacy, trust in online sources of information, and food allergy quality of life (QoL) and self-efficacy. METHODS: An online survey was administered to caregivers of FAIs assessing health literacy (Newest Vital Sign [NVS] and the eHeals Internet health literacy index), trust in online information (Hargittai Internet credibility index and Annenberg National Health Communication Survey [ANHCS]), QoL (Food Allergy Quality of Life Parental Burden), and self-efficacy (Food Allergy Self-Efficacy Questionnaire [FASEQ])...
September 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27604174/allergen-specific-ige-measurement-intermethod-comparison-of-two-assay-systems-in-diagnosing-clinical-allergy
#17
Sandra Bulat Lokas, Davor Plavec, Josipa Rikić Pišković, Jelena Živković, Boro Nogalo, Mirjana Turkalj
BACKGROUND: Our aim was to examine the performance of IMMULITE 2000 assay for specific IgE (sIgE) by comparing it with ImmunoCAP technology in light of a clinical background. METHODS: Measurements of sIgE were done in a selected patient group (N = 569; varied sample size for each allergen) and in a random sample group (N = 100; 8 allergens). sIgE results were correlated with skin-prick test results (selected patients) and medical history (nonselected patients). RESULTS: We have detected fair to excellent correlation and agreement between the results of both assays, despite their methodological differences, both in selected and nonselected patient group (ρc = 0...
September 8, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27600320/recommendations-for-prevention-and-control-of-influenza-in-children-2016-2017
#18
(no author information available yet)
The purpose of this statement is to update recommendations for the routine use of seasonal influenza vaccine and antiviral medications for the prevention and treatment of influenza in children. The AAP recommends annual seasonal influenza immunization for everyone 6 months and older, including children and adolescents. Highlights for the upcoming 2016-2017 season include the following: 1. Annual universal influenza immunization is indicated with either a trivalent or quadrivalent (no preference) inactivated vaccine...
September 6, 2016: Pediatrics
https://www.readbyqxmd.com/read/27592278/food-allergy-in-catalonia-clinical-manifestations-and-its-association-with-airborne-allergens
#19
J Sánchez-López, V Gázquez, N Rubira, L Valdesoiro, M Guilarte, A Garcia-Moral, N Depreux, L Soto-Retes, M De Molina, O Luengo, R Lleonart, M Basagaña
BACKGROUND: Food allergy affects around 6% of the European population and its prevalence worldwide has been increasing in the last decades, but studies focused on investigating food allergy epidemiology in Europe are lacking. OBJECTIVE: The Cibus project was created to register the main culprit foods and their clinical manifestations in food allergic patients in Catalonia. METHODS: A specific online database was designed. Allergists from eight different Catalan hospitals registered the new diagnoses of food allergy...
August 31, 2016: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/27582405/a-multicenter-retrospective-case-study-of-anaphylaxis-triggers-by-age-in-korean-children
#20
So Yeon Lee, Kangmo Ahn, Jihyun Kim, Gwang Cheon Jang, Taek Ki Min, Hyeon Jong Yang, Bok Yang Pyun, Ji Won Kwon, Myung Hyun Sohn, Kyung Won Kim, Kyu Earn Kim, Jinho Yu, Soo Jong Hong, Jung Hyun Kwon, Sung Won Kim, Tae Won Song, Woo Kyung Kim, Hyung Young Kim, You Hoon Jeon, Yong Ju Lee, Hae Ran Lee, Hye Young Kim, Youngmin Ahn, Hye Yung Yum, Dong In Suh, Hyun Hee Kim, Jin Tack Kim, Jeong Hee Kim, Yong Mean Park, Sooyoung Lee
PURPOSE: Although anaphylaxis is recognized as an important, life-threatening condition, data are limited regarding its triggers in different age groups. We aimed to identify anaphylaxis triggers by age in Korean children. METHODS: We performed a retrospective review of medical records for children diagnosed with anaphylaxis between 2009 and 2013 in 23 secondary or tertiary hospitals in South Korea. RESULTS: A total of 991 cases (mean age=5...
November 2016: Allergy, Asthma & Immunology Research
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