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https://www.readbyqxmd.com/read/28230769/hypoallergenic-variant-of-the-major-egg-white-allergen-gal-d-1-produced-by-disruption-of-cysteine-bridges
#1
Pathum Dhanapala, Dulashi Withanage-Dona, Mimi L K Tang, Tim Doran, Cenk Suphioglu
Gal d 1 (ovomucoid) is the dominant allergen in the chicken egg white. Hypoallergenic variants of this allergen can be used in immunotherapy as an egg allergy treatment approach. We hypothesised that disruption of two of the nine cysteine-cysteine bridges by site-directed mutagenesis will allow the production of a hypoallergenic variant of the protein; Methods: Two cysteine residues at C192 and C210 in domain III of the protein were mutated to alanine using site-directed mutagenesis, to disrupt two separate cysteine-cysteine bridges...
February 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28226324/a-survey-of-self-reported-food-allergy-and-food-related-anaphylaxis-among-young-adult-students-at-kuwait-university-kuwait
#2
Fatima Ali
OBJECTIVES: To conduct a survey on self-reported food allergy to milk, egg, peanuts, tree nuts, fish, shellfish, wheat and sesame as well as reported food-related anaphylaxis and epinephrine prescription practices among Kuwaiti students attending Kuwait University. SUBJECTS AND METHODS: One thousand (1,000) questionnaires that included data on age, gender, presence of food allergies and associated details were distributed. All participants reporting an allergy were categorized as having a perceived food allergy...
February 22, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28226319/oral-and-sublingual-immunotherapy-potential-causes-for-eosinophilic-gastrointestinal-disorders
#3
Delara Babaie, Mehrnaz Mesdaghi, Makoto Nishino, Mahboubeh Mansouri, Motohiro Ebisawa
Food allergy is a common health problem worldwide, with increasing prevalence during recent decades. The only approved treatments for food allergy are food avoidance and administration of emergency medications in case of accidental exposure, which negatively affects patients' quality of life, so new treatments are highly desirable. Different food immunotherapy modalities have recently been used, with variable success rates in the induction of desensitization and tolerance, and different numbers and types of adverse reactions...
February 23, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28221935/egg-and-milk-proteins-as-hidden-allergens-in-food-5-year-2010-to-2014-results-of-food-allergen-monitoring-in-piedmont-italy
#4
Daniela Manila Bianchi, Daniela Adriano, Sara Astegiano, Silvia Gallina, Maria Caramelli, Lucia Decastelli
Cow's milk and egg allergies are two of the most common food allergies. Manufacturers of food products containing milk or eggs or their derivatives as an ingredient are required by European Union regulations to list their presence on the ingredient label. Under European Union legislation, member states are mandated to carry out food safety monitoring programs to verify compliance with food labeling requirements. Through the Regional Integrated Plan for Food Safety, the Piedmont (Italy) regional authority carries out an annual program to determine the presence of undeclared allergens in foods...
September 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28211344/validation-of-recipes-for-double-blind-placebo-controlled-challenges-with-milk-egg-white-and-hazelnut
#5
E González-Mancebo, M D Alonso Díaz de Durana, Y García Estringana, A Meléndez Baltanás, M Rodriguez-Alvarez, B de la Hoz Caballer, N Del Prado, M Fernández-Rivas
BACKGROUND: The double-blind, placebo-controlled food challenge (DBPCFC) is considered the definitive diagnostic test for food allergy. Nevertheless, validated recipes for masking the foods are scarce, have not been standardized, and differ between centers. Sensory evaluation techniques such as the triangle test are necessary to validate the recipes used for DBPCFC. METHODS: We developed 3 recipes for use in DBPCFC with milk, egg white, and hazelnut and used the triangle test to validate them in a 2-phase study in which 197 volunteers participated...
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28211100/safety-and-feasibility-of-heated-egg-yolk-challenge-for-children-with-egg-allergies
#6
Noriyuki Yanagida, Sakura Sato, Tomoyuki Asaumi, Kiyotake Ogura, Magnus P Borres, Motohiro Ebisawa
BACKGROUND: Hen's egg allergy is a frequent cause of childhood food allergy. Egg yolk is used in various commonly consumed foods; if children with allergy to hen's egg could eat heated egg yolk, their quality of life (QOL) would improve. No reports exist regarding oral food challenges (OFCs) for heated egg yolk. We aimed to clarify whether pediatric patients allergic to hen's egg could consume heated egg yolk. METHODS: Data from pediatric patients who had undergone OFCs for heated egg yolk were evaluated retrospectively...
February 16, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28201853/antigenic-cross-reactivity-between-schistosoma-mansoni-and-peanut-a-role-for-cross-reactive-carbohydrate-determinants-ccds-and-implications-for-the-hygiene-hypothesis
#7
Joseph E Igetei, Marwa El-Faham, Susan Liddell, Michael J Doenhoff
The antigenic reactivity of constituents of Schistosoma mansoni and peanut (Arachis hypogaea) was investigated to determine whether identical antigenic epitopes possessed by both organisms provided a possible explanation for the negative correlation between chronic schistosome infection and atopy to allergens. Aqueous extracts of peanuts were probed in Western immunoblots with rabbit IgG antibodies raised against the egg, cercarial and adult worm stages of S. mansoni. Several molecules in the peanut extract were antigenically reactive with antibodies from the various rabbit anti-schistosome sera...
February 15, 2017: Immunology
https://www.readbyqxmd.com/read/28194188/primum-non-nocere-first-do-no-harm-and-then-feed-peanut
#8
Kyla Jade Hildebrand, Elissa Michele Abrams, Timothy K Vander Leek, Julia Elizabeth Mainwaring Upton, Douglas P Mack, Linda Kirste, Christine McCusker, Sandeep Kapur
The Addendum Guidelines for the Prevention of Peanut Allergy in the United States-Report of the NIAID-Sponsored Expert Panel were developed to build on previous food allergy guidelines after several key studies demonstrated the benefit of early introduction of allergenic foods. These landmark studies including the Learning Early about Peanut (LEAP), LEAP-On and Enquiring about Tolerance trials created a paradigm shift in food allergy prevention. The "take home" messages of this guideline include that peanut should be introduced early in the first year of life, and for the majority of infants, peanut can be introduced at home...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/28173607/review-suggests-that-the-immunoregulatory-and-anti-inflammatory-properties-of-allergenic-foods-can-provoke-oral-tolerance-if-introduced-early-to-infants-diets
#9
REVIEW
Despina-Zoe T Mermiri, Theodora Lappa, Athina L Papadopoulou
: For years, the advice was to postpone introducing allergenic foods, in order to prevent food allergies. However, food allergies have escalated rather than declined and our review of the latest epidemiological, immunological and nutritional research suggests that early weaning practices may be beneficial. The most allergenic foods, such as fish, eggs and peanuts, have proved to be inherently rich in tolerogenic substances that can play a significant role in preventing allergies. CONCLUSION: We found evidence that the immunoregulatory and anti-inflammatory properties of allergenic foods can provoke oral tolerance if introduced early to both low-risk and high-risk infants...
February 7, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28165776/late-presentation-of-egg-white-and-milk-protein-allergy-as-rhinitis-and-otitis-media
#10
Matthew Haywood, Adebayo Alade, Ananth Vijendren, Pranay Singh
No abstract text is available yet for this article.
February 2, 2017: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/28159385/tolerance-development-in-food-protein-induced-allergic-proctocolitis-single-centre-experience
#11
S B Erdem, H T Nacaroglu, S Karaman, C B Erdur, C U Karkıner, D Can
BACKGROUND: Food protein-induced allergic proctocolitis (FPIAP) is characterised by inflammation of the distal colon in response to one or more food proteins. It is a benign condition of bloody stools in a well-appearing infant, with usual onset between one and four weeks of age. OBJECTIVE: Our objective was to examine the clinical properties of patients with FPIAP, tolerance development time as well as the risk factors that affect tolerance development. METHODS: The clinical symptoms, offending factors, laboratory findings, methods used in the diagnosis and tolerance development for 77 patients followed in the Paediatric Allergy and Gastroenterology Clinics with the diagnosis of FPIAP during January 2010-January 2015 were examined in our retrospective cross-sectional study...
February 1, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28120742/the-national-institutes-of-allergy-and-infectious-diseases-sponsored-guidelines-on-preventing-peanut-allergy-a-new-paradigm-in-food-allergy-prevention
#12
M Greenhawt
Peanut allergy is a significant public health problem without proven treatment or cure at present. In 2000, the AmericanAcademy of Pediatrics recommended that solid-food introduction be delayed in infants at high risk, including peanut introduction, until age 3 years. In 2008, the American Academy of Pediatrics revised these recommendations based on limited evidence of benefit and, instead, recommended solid-food introduction not be delayed past 4-6 months of life. In 2015, the Learning Early About Peanut Allergy study showed that early peanut introduction (between 4 and 11 months of life) was associated with a significant absolute and relative risk reduction in the development of peanut allergy compared with delayedintroduction...
January 24, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28120607/anaphylaxis-to-hidden-potato-allergens-in-a-peach-and-egg-allergic-boy
#13
M F Martín-Muñoz, A Diaz-Perales, J Cannabal, S Quirce
More than 170 foods have been identified as being potentially allergenic. However, a minority of these foods cause the majority of reactions. Sweets are frequently implicated in allergic reactions in children with cow's milk, egg, nuts or fruits allergy, and they are the most relevant foods investigated as responsible allergens. We report an anaphylactic reaction to candies in an egg and peach allergic boy. We performed a study to identify responsible allergens for the reaction. We investigated hidden egg and peach allergens in the candies, but they were not found...
January 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28120606/a-very-unusual-case-of-food-allergy-between-fpies-and-ige-mediated-food-allergy
#14
S Miceli Sopo, S Monaco, G Cerchiara, G Bersani
Food protein induced enterocolitis syndrome (FPIES) is a food-related gastrointestinal hypersensitivity disorder, probably non-IgE-mediated. Over the years, various diagnostic criteria have been proposed to identify FPIES. In the last few years, there was an increased interest from researchers about FPIES's syndrome, that frequently brought to discover new aspects of this disease. We describe an unusual case of FPIES to egg in a 21-months-old child, because of its clinical characteristics that reflect some aspects of IgE-mediated allergy and other of non IgE-mediated allergy...
January 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28049193/safety-and-efficacy-of-low-dose-oral-immunotherapy-for-hen-s-egg-allergy-in-children
#15
Noriyuki Yanagida, Sakura Sato, Tomoyuki Asaumi, Kenichi Nagakura, Kiyotake Ogura, Motohiro Ebisawa
BACKGROUND: The minimal dose for oral immunotherapy (OIT) tolerance is unknown. We investigated the efficacy and safety of low-dose OIT with 1/32 of the volume of a whole egg. METHODS: Thirty-three children (aged ≥5 years) with egg allergies confirmed by oral food challenge against 1/32 of a heated whole egg (194 mg of egg protein) were enrolled. The OIT group ingested a scrambled egg once a day. The volume was gradually increased up to a maximum of 1/32 of a heated whole egg...
2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28042676/vitamin-d-insufficiency-in-the-first-6-months-of-infancy-and-challenge-proven-ige-mediated-food-allergy-at-1-year-of-age-a-case-cohort-study
#16
John Molloy, Jennifer J Koplin, Katrina J Allen, Mimi L K Tang, Fiona Collier, John B Carlin, Richard Saffery, David Burgner, Sarath Ranganathan, Terence Dwyer, Alister C Ward, Margarita Moreno-Betancur, Michael Clarke, Anne Louise Ponsonby, Peter Vuillermin
BACKGROUND: Ecological evidence suggests vitamin D insufficiency (VDI) due to lower ambient ultraviolet radiation (UVR) exposure may be a risk factor for IgE-mediated food allergy. However there are no studies relating directly measured VDI during early infancy to subsequent challenge-proven food allergy. OBJECTIVE: To prospectively investigate the association between VDI during infancy and challenge-proven food allergy at 1 year. METHODS: In a birth cohort (n=1074), we used a case-cohort design to compare 25-hydroxy-vitamin-D3 (25(OH)D3 ) levels among infants with food allergy versus a random subcohort (n=274)...
January 2, 2017: Allergy
https://www.readbyqxmd.com/read/28042003/the-prevalence-of-eosinophilic-esophagitis-in-pediatric-patients-with-ige-mediated-food-allergy
#17
David A Hill, Jesse W Dudley, Jonathan M Spergel
BACKGROUND: Eosinophilic esophagitis (EoE) is an allergic inflammatory disease that is triggered by food allergens and characterized by progressive esophageal dysfunction. Recently, EoE has been identified in patients who underwent oral immunotherapy (OIT) for IgE-mediated food allergy, suggesting an association. OBJECTIVE: We sought to ascertain whether significant associations exist between IgE-mediated food allergies and EoE. METHODS: Using the analysis of electronic medical record data and manual chart review, we examined our subspecialty care network of 35,528 children and adolescents to identify and characterize patients with IgE-mediated and EoE food allergy...
December 30, 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28039897/early-introduction-of-food-reduces-food-allergy-pro
#18
Debra J Palmer, Susan L Prescott
Over the past two decades we have been debating the question of whether the age of commencement of complementary feeding affects the risk of developing food allergy. We ate up the notion that delayed introduction of more allergenic foods in early childhood, would help overcome the increasing rates of food allergy, then we promptly spat it out again despite limited evidence. Recently high-quality randomised controlled trial evidence has given us the confidence to swallow the concept that allergenic foods, like egg and peanut, should be given to infants...
December 31, 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28027215/complementary-feeding-a-position-paper-by-the-european-society-for-paediatric-gastroenterology-hepatology-and-nutrition-espghan-committee-on-nutrition
#19
Mary Fewtrell, Jiri Bronsky, Cristina Campoy, Magnus Domellöf, Nicholas Embleton, Nataša Fidler Mis, Iva Hojsak, Jessie M Hulst, Flavia Indrio, Alexandre Lapillonne, Christian Molgaard
: This position paper considers different aspects of complementary feeding (CF), focussing on healthy term infants in Europe. After reviewing current knowledge and practices, we have formulated these recommendations: Timing: Exclusive or full breast-feeding should be promoted for at least 4 months (17 weeks, beginning of the 5th month of life) and exclusive or predominant breast-feeding for approximately 6 months (26 weeks, beginning of the 7th month) is a desirable goal. Complementary foods (solids and liquids other than breast milk or infant formula) should not be introduced before 4 months but should not be delayed beyond 6 months...
January 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28007089/epidemiology-of-anaphylaxis-at-a-tertiary-care-center-a-report-of-730-cases
#20
Alexei Gonzalez-Estrada, Stacy K Silvers, Asaf Klein, Katrina Zell, Xiao-Feng Wang, David M Lang
BACKGROUND: Recent data reveal that the rate of anaphylaxis is increasing and suggest that idiopathic anaphylaxis may account for most of these cases. OBJECTIVE: To determine the pattern of anaphylaxis at a tertiary care referral center. METHODS: A retrospective electronic medical record review spanning 12 years (2002-2013) identified patients with anaphylaxis. RESULTS: Of the 4,777 records reviewed, 730 patients met our anaphylaxis definition...
January 2017: Annals of Allergy, Asthma & Immunology
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