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https://www.readbyqxmd.com/read/29161056/de-novo-food-allergy-in-pediatric-liver-transplantation-recipients
#1
Ratchaneewan Sinitkul, Wiparat Manuyakorn, Wasu Kamchaisatian, Soamarat Vilaiyuk, Suwat Benjaponpitak, Chatmanee Lertudompholwanit, Suporn Treepongkaruna
BACKGROUND: Food allergy (FA) prevalence is increasing in pediatric liver transplantation (LT). However, the clinical course is still limited. OBJECTIVE: This retrospective cohort study aimed to identify the prevalence, risk factors, and the natural history of de novo FA in children post LT. METHODS: Medical records of pediatric LT recipients from Jan 2001 - Dec 2014 were reviewed. De novo FA was diagnosed by symptoms after exposure to culprit food occurring after LT, and improvement after diet elimination...
November 22, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/29154959/early-life-innate-immune-signatures-of-persistent-food-allergy
#2
Melanie R Neeland, Jennifer J Koplin, Thanh D Dang, Shyamali C Dharmage, Mimi L Tang, Susan L Prescott, Richard Saffery, David J Martino, Katrina J Allen
BACKGROUND: Food allergy naturally resolves in a proportion of food allergic children without intervention, however the underlying mechanisms governing the persistence or resolution of food allergy in childhood are not understood. OBJECTIVES: This study aimed to define the innate immune profiles associated with egg allergy at one year of age, determine the phenotypic changes that occur with the development of natural tolerance in childhood and explore the relationship between early life innate immune function and serum vitamin D...
November 14, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29153880/food-allergy-is-an-important-risk-factor-for-childhood-asthma-irrespective-of-whether-it-resolves
#3
Evelien M Vermeulen, Jennifer J Koplin, Shyamali C Dharmage, Lyle C Gurrin, Rachel L Peters, Vicki McWilliam, Anne-Louise Ponsonby, Terence Dwyer, Adrian J Lowe, Mimi L K Tang, Katrina J Allen
BACKGROUND: The risk of developing asthma in those with early food allergy is unknown, particularly when early life food allergy has resolved. OBJECTIVE: To understand whether challenge-proven food allergy in infancy increases the risk of asthma at age 4 years, using data from a population-based cohort. METHODS: A total of 5,276 12-month-old infants were recruited using a population-based sampling frame. Infants underwent skin prick test to egg, peanut, and sesame and those with a detectable skin prick test result had oral food challenges...
November 15, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29151834/late-introduction-of-fish-and-eggs-is-associated-with-increased-risk-of-allergy-development-results-from-the-farmflora-birth-cohort
#4
K Jonsson, M Barman, H K Brekke, B Hesselmar, S Johansen, A-S Sandberg, A E Wold
The prevalence of allergy is markedly low in children growing up on farms. An increasing number of studies indicate that the timing of food introduction may affect allergy development. We aimed to investigate if protection against allergy in farm environments may be mediated through differences in food-introduction practices between farm and non-farm families, using an explorative approach. Twenty-eight farm and 37 non-farm children were included in the FARMFLORA birth cohort. Practices of breastfeeding and introduction of formulas and complementary foods were collected by questionnaires at 6, 12, and 18 months of age...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/29140656/an-analysis-of-%C3%A2-natural%C3%A2-food-litigation-to-build-a-sesame-allergy-consumer-class-action
#5
Dana Shaker
In a world where food allergy is still an incurable disease, law and regulation stand as necessary mechanisms to provide food-allergic consumers with the information they need to protect their health. The Food Allergen Labeling and Consumer Protection Act of 2004 provided specific labeling requirements for the “Top Eight” allergens in the U.S.: milk, soy, gluten, egg, tree nut, peanut, fish, and Crustacean shellfish. Since then, sesame has become more prevalent as an allergen and remains just as dangerous, inducing anaphylactic shock in some sesame-allergic individuals...
2017: Food and Drug Law Journal
https://www.readbyqxmd.com/read/29138881/a-harmonized-immunoassay-with-liquid-chromatography-mass-spectrometry-analysis-in-egg-allergen-determination
#6
Masaomi Nimata, Hideki Okada, Kei Kurihara, Tsukasa Sugimoto, Tsutomu Honjoh, Kazuhiko Kuroda, Takeo Yano, Hirofumi Tachibana, Masahiro Shoji
Food allergy is a serious health issue worldwide. Implementing allergen labeling regulations is extremely challenging for regulators, food manufacturers, and analytical kit manufacturers. Here we have developed an "amino acid sequence immunoassay" approach to ELISA. The new ELISA comprises of a monoclonal antibody generated via an analyte specific peptide antigen and sodium lauryl sulfate/sulfite solution. This combination enables the antibody to access the epitope site in unfolded analyte protein. The newly developed ELISA recovered 87...
November 14, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29132675/the-role-of-baked-egg-and-milk-in-the-diets-of-allergic-children
#7
REVIEW
Melissa L Robinson, Bruce J Lanser
Baked egg and baked milk are tolerated by most children who are allergic to hen's egg and cow's milk. Incorporating baked goods into the diets of allergic children may help them outgrow their primary allergy more quickly, with changes observed akin to immunotherapy. Benefits may also include increased quality of life and improved nutritional status. The search for a reliable biomarker to predict tolerance to baked goods is ongoing. Most children with a milk or egg allergy who are not previously tolerating egg or milk in baked goods should be offered an observed oral food challenge...
February 2018: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/29132669/epidemiology-of-food-allergy
#8
REVIEW
Joan H Dunlop, Corinne A Keet
Understanding the epidemiology of food allergy is complicated by the difficulty of identifying it on a large scale. The prevalence of food allergy is higher in younger age groups and decreases with age. Allergy to peanut and egg seems to be more common in Northern Europe, the United States, Canada and Australia compared with Southern Europe, Eastern Europe and Asia, whereas shellfish and fish allergies may be more common in Asia. The rate of transient unrecognized food allergy may be high and variable recognition of food allergy may explain some of the differences seen in food allergy prevalence...
February 2018: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/29130935/histamine-releasing-factor-enhances-food-allergy
#9
Tomoaki Ando, Jun-Ichi Kashiwakura, Naoka Itoh-Nagato, Hirotaka Yamashita, Minato Baba, Yu Kawakami, Shih Han Tsai, Naoki Inagaki, Kiyoshi Takeda, Tsutomu Iwata, Naoki Shimojo, Takao Fujisawa, Mizuho Nagao, Kenji Matsumoto, Yuko Kawakami, Toshiaki Kawakami
Food allergy occurs due to IgE- and mast cell-dependent intestinal inflammation. Previously, we showed that histamine-releasing factor (HRF), a multifunctional protein secreted during allergy, interacts with a subset of IgE molecules and that the HRF dimer activates mast cells in an HRF-reactive IgE-dependent manner. In this study, we investigated whether HRF plays any role in food allergy. Specifically, we determined that prophylactic and therapeutic administration of HRF inhibitors that block HRF-IgE interactions reduces the incidence of diarrhea and mastocytosis in a murine model of food allergy...
November 13, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29130933/histamine-releasing-factor-a-promising-therapeutic-target-for-food-allergy
#10
Marsha Wills-Karp
The prevalence of food allergies has been increasing at an alarming rate over the last few decades. Despite the dramatic increase in disease prevalence, the development of effective therapies has not kept pace. In this issue of the JCI, Ando et al. provide a causal link between histamine-releasing factor (HRF) interactions with IgE and food allergy in a murine model. Successful oral immunotherapy of both egg-allergic human patients and food-allergic mice was associated with sustained suppression of HRF-reactive IgE levels...
November 13, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29129889/-an-adult-case-of-egg-allergy-treated-with-rush-oral-immunotherapy
#11
Mayumi Yamazaki, Atsushi Isozaki, Aki Tanaka, Eriko Ando, Yoichi Nakamura, Kazuyuki Kurihara
A 26-year-old female patient exhibited symptoms associated with egg allergy, which had been present since early childhood. The patient requested the treatment of egg allergy and was admitted to our hospital for rush oral immunotherapy. The threshold was determined by an oral food challenge test, after positive results on a double-blind food challenge test. The patient ingested dry powder of raw egg-white 5 times per day starting with a tenth of the threshold dose (3.0mg), followed by a 1.2-times increase every time...
2017: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/29101472/a-kudoa-septempunctata-antigen-induces-production-of-ige-in-balb-c-mice
#12
Takahiro Ohnishi, Aya Kubo, Tomoya Yoshinari, Maiko Watanabe
Kudoa septempunctata, a myxosporean parasite, is the causative agent of a foodborne illness associated with consumption of raw Paralichthys olivaceus (olive flounder). Because the lag phase of this illness is short (from 1 to 12 h), it is possible that an allergic response is relevant to this illness. To test whether a K. septempunctata antigen is the possible allergen, we injected a myxospore extract into BALB/c mice and measured IgE levels in serum. When the mice were injected with the myxospore extract, the total serum IgE concentration increased significantly after the second immunization as compared to the negative control...
November 3, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29098994/correlation-of-cutaneous-sensitivity-and-cytokine-response-in-children-with-asthma
#13
Meenu Singh, Amit Agarwal, Bishnupada Chatterjee, Anil Chauhan, Rashmi Ranjan Das, Nandini Paul
BACKGROUND: Food allergy occurs in a significant portion of pediatric asthma. Various cells and their mediators/cytokines play a pivotal role in orchestrating the airway inflammatory response in asthma. OBJECTIVE: To study the cutaneous hypersensitivity, Th1, Th2, and Th17 response of pediatric population with asthma and genetic predisposition to atopy, by determining total immunoglobulin E (IgE) level in response to various food allergens. MATERIALS AND METHODS: Fifty asthmatic children with a history of worsening symptoms by various food allergens (study group) and twenty healthy children (control group) were included...
November 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29097103/the-allergen-specificity-of-early-peanut-consumption-and-the-impact-on-the-development-of-allergic-disease-in-the-leap-study-cohort
#14
George du Toit, Peter H Sayre, Graham Roberts, Kaitie Lawson, Michelle L Sever, Henry T Bahnson, Helen R Fisher, Mary Feeney, Suzana Radulovic, Monica Basting, Marshall Plaut, Gideon Lack
BACKGROUND: Early introduction of dietary peanut in high-risk infants with severe eczema and/or egg allergy prevented peanut allergy at 5 years of age in the LEAP Study; the protective effect persisted after 12 months of avoiding peanuts in the LEAP-On Study. It is unclear whether this benefit is allergen and allergic-disease specific. OBJECTIVE: To assess the impact of early introduction of peanut on the development of allergic disease, food sensitization and aeroallergen sensitization...
October 30, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29074386/unlike-th1-th17%C3%A2-cells-th2-th9-cells-selectively-migrate-to-the-limbus-conjunctiva-and-initiate-an-eosinophilic-infiltration-process
#15
Cuiyan Tan, Wambui S Wandu, Anthony St Leger, Jennifer Kielczewski, Eric F Wawrousek, Chi-Chao Chan, Igal Gery
In this study we compared polarized mouse T-helper (Th) lymphocytes of four populations, sensitized against an ocular antigen, for their patterns of migration and induction of inflammatory processes in recipient mouse eyes expressing the target antigen. Th1, Th2, Th9 and Th17 cells transgenically expressing T-cell receptor (TCR) specific against hen egg lysozyme (HEL) were adoptively transferred to recipient mice expressing HEL in their eyes. Recipient eyes collected 4 or 7 days post injection were analyzed for histopathological changes...
October 24, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/29070273/oral-immunotherapy-in-children-with-ige-mediated-hen-s-egg-allergy-follow-ups-at-2-5-and-7-years
#16
Paolo Meglio, Paolo Gianni Giampietro, Rossella Carello, Elena Galli
BACKGROUND: The present report was a follow-up investigation at 2.5- and 7-year intervals of a previous study of 20 children with moderate-to-severe immunoglobulin E (IgE) mediated hen's egg (HE) allergy who received oral immunotherapy (OIT) with raw HE. The study design of the previous study divided the 20 subjects into two groups of 10 each: (1) group 1, the OIT group (OIT-G), and, (2) group 2, an age-matched control group (C-G). In that study, 8 of 10 of the children in the OIT-G were successfully desensitized, one child was partially desensitized, and desensitization failed in one child...
October 1, 2017: Allergy & Rhinology
https://www.readbyqxmd.com/read/29068090/early-introduction-of-allergenic-foods-for-the-prevention-of-food-allergy-from-an-asian-perspective-an-apapari-consensus-statement
#17
REVIEW
E H Tham, L P Shek, H P Van Bever, P Vichyanond, M Ebisawa, G W K Wong, B W Lee
Emerging evidence for the early introduction of allergenic foods for the prevention of food allergies, such as peanut allergy in Western populations, has led to the recent publication of guidelines in the US and Europe recommending early peanut introduction for high-risk infants with severe eczema or egg allergy. Peanut allergy is, however, much less prevalent in Asia compared to the West. Varying patterns of food allergy are seen even within Asian countries - such as a predominance of wheat allergy in Japan and Thailand and shellfish allergy in Singapore and the Philippines...
October 25, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29047183/follow-up-of-patients-with-uncertain-symptoms-during-an-oral-food-challenge-is-useful-for-diagnosis
#18
Taro Miura, Noriyuki Yanagida, Sakura Sato, Kiyotake Ogura, Motohiro Ebisawa
BACKGROUND: Uncertain symptoms often emerge during an oral food challenge (OFC) and Open-OFCs with those uncertain mild symptoms are ordinarily regarded as positive. Double-blind placebo-controlled food challenges should be conducted in order to determine these associations. Nevertheless, studies regarding the diagnosis of uncertain food allergy symptoms are lacking. We examined the diagnostic decision for a food allergy based on uncertain symptoms during an Open-OFC. METHODS: We conducted an Open-OFC between August 2005 and April 2012 with 2271 cases who suspected as allergic to hen's eggs, cow's milk, or wheat...
October 19, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29025097/measuring-the-impact-of-differences-in-risk-factor-distributions-on-cross-population-differences-in-disease-occurrence-a-causal-approach
#19
Margarita Moreno-Betancur, Jennifer J Koplin, Anne-Louise Ponsonby, John Lynch, John B Carlin
Background: In cross-population comparisons of disease occurrence (prevalence, incidence), a common public health question is the extent to which variations in the distribution of risk factors for the disease explain observed differences. Limited work has been done on formalizing this problem, which is conceptually tantamount to quantifying the degree of confounding for the 'population effect' induced by different factors. A common approach is to compare 'unadjusted' and 'adjusted' regression-based estimates of that parameter, but the interpretation of the resulting 'contribution' measures may be hindered by other confounding sources and non-collapsibility issues...
September 18, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29017902/small-percentage-of-anaphylactic-reactions-treated-with-epinephrine-during-food-challenges-in-dutch-children
#20
Johanna P M van der Valk, Irene Berends, Roy Gerth van Wijk, Nicolette J T Arends, Maurits S van Maaren, Hans de Groot, Harry J Wichers, Joyce A M Emons, Anthony E J Dubois, Nicolette W de Jong
BACKGROUND: Severe allergic reactions, including anaphylaxis, occur during oral food challenges (OFCs) and the first-line treatment of anaphylaxis is epinephrine. OBJECTIVE: To evaluate the percentage of anaphylactic reactions treated with epinephrine during OFCs and to identify associated factors for the administration of epinephrine. METHODS: Children who underwent an OFC with peanut, hazelnut, cow's milk, hen's egg, or cashew nut from 2005 through 2015 in the Netherlands were evaluated...
October 7, 2017: Annals of Allergy, Asthma & Immunology
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