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"Collective impact"

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https://www.readbyqxmd.com/read/28086863/exercise-mediated-protection-of-diabetic-heart-through-modulation-of-microrna-mediated-molecular-pathways
#1
REVIEW
Jason Kar Sheng Lew, James T Pearson, Daryl O Schwenke, Rajesh Katare
Hyperglycaemia, hypertension, dyslipidemia and insulin resistance collectively impact on the myocardium of people with diabetes, triggering molecular, structural and myocardial abnormalities. These have been suggested to aggravate oxidative stress, systemic inflammation, myocardial lipotoxicity and impaired myocardial substrate utilization. As a consequence, this leads to the development of a spectrum of cardiovascular diseases, which may include but not limited to coronary endothelial dysfunction, and left ventricular remodelling and dysfunction...
January 13, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28050803/access-to-controlled-medicines-for-anesthesia-and-surgical-care-in-low-income-countries-a-narrative-review-of-international-drug-control-systems-and-policies
#2
Jason W Nickerson, Katherine Pettus, Kathleen E Wheeler, Christopher Hallam, David R Bewley-Taylor, Amir Attaran, Adrian W Gelb
PURPOSE: This article describes the functioning of the international drug control system, its integration into national legislation and policy, and the collective impact on access to medicines. SOURCE: We conducted a review of the three international drug control conventions, peer-reviewed articles, and grey literature known to the authors that describes national and international drug control systems and their impact on access to controlled medicines. This review was supplemented with literature derived from a structured search of MEDLINE(®) for articles relating to medical uses of ketamine in low- and middle-income countries conducted to strengthen an advocacy campaign...
January 3, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/27981189/untangling-the-gordian-knot-of-hiv-stress-and-cognitive-impairment
#3
REVIEW
Arielle N Valdez, Leah H Rubin, Gretchen N Neigh
As individuals live longer with HIV, this "graying of the HIV epidemic" has introduced a new set of challenges including a growing number of age and inflammation-related diseases such as cardiovascular disease, type II diabetes, cancer, and dementia. The biological underpinnings of these complex and co-morbid diseases are not fully understood and become very difficult to disentangle in the context of HIV and aging. In the current review we examine the contributions and interactions of HIV, stress, and cognitive impairment and query the extent to which inflammation is the linchpin in these dynamic interactions...
October 2016: Neurobiology of Stress
https://www.readbyqxmd.com/read/27977295/research-progress-in-tofu-processing-from-raw-materials-to-processing-conditions
#4
Qing Zhang, Chenzhi Wang, Bokang Li, Lin Li, Derong Lin, Hong Chen, Yaowen Liu, Suqing Li, Wen Qin, Jiang Liu, Weiguo Liu, Wenyu Yang
As a traditional soybean product with good quality and a healthy food with many functional components, tofu is increasingly consumed in people's daily life. Traditional tofu processing consists of numerous steps, including the soaking and grinding of soybean seeds, heating of the soybean slurry, filtering, and addition of coagulants, and others. The properties of soybean seeds, processing scale, soaking and heating conditions, type and concentration of coagulant and other factors collectively impact the processing steps and the final tofu quality...
December 15, 2016: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/27878353/does-mri-of-the-thoracolumbar-spine-change-management-in-blunt-trauma-patients-with-stable-thoracolumbar-spinal-injuries-without-neurologic-deficits
#5
Paul Deramo, Vaidehi Agrawal, Joseph Amos, Nimesh Patel, Henry Jefferson
BACKGROUND: In blunt trauma patients with computed tomography (CT) findings of stable thoracolumbar (TL) spinal injury without neurologic deficits, magnetic resonance imaging (MRI) studies are commonly obtained, though the impact on overall management remains unclear. The indication for MRI in patients with TL injury without neurologic deficits continues to remain unclear. Here, we evaluate the role of MRI on clinical management of patients presenting with this diagnosis. METHODS: After IRB approval, all registry patients from December 2005 to December 2015 with all blunt TL injuries without defects were extracted...
November 22, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27768558/developing-indicators-for-evaluation-of-age-friendly-communities-in-canada-process-and-results
#6
H Orpana, M Chawla, E Gallagher, E Escaravage
INTRODUCTION: In 2006, the World Health Organization launched the Global Age-Friendly Cities Project to support active aging. Canada has a large number of age-friendly initiatives; however, little is known about the effectiveness and outcomes of age-friendly community (AFC) initiatives. In addition, stakeholders report that they lack the capacity and tools to develop and conduct evaluations of their AFC initiatives. In order to address these gaps, the Public Health Agency of Canada developed indicators to support the evaluation of AFC initiatives relevant to a wide range of Canadian communities...
October 2016: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/27763428/developing-a-sustainable-model-of-oral-health-care-for-disadvantaged-aboriginal-people-living-in-rural-and-remote-communities-in-nsw-using-collective-impact-methodology
#7
Kylie Gwynne, Michelle J Irving, Debbie McCowen, Boe Rambaldini, John Skinner, Steve Naoum, Anthony Blinkhorn
A sustainable model of oral health care for disadvantaged Aboriginal people living in rural and remote communities in New South Wales was developed using collective impact methodology. Collective impact is a structured process which draws together organizations to develop a shared agenda and design solutions which are jointly resourced, measured and reported upon.
2016: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/27693004/collective-impact-of-conventional-cardiovascular-risk-factors-and-coronary-calcium-score-on-clinical-outcomes-with-or-without-statin-therapy-the-st-francis-heart-study
#8
Salman Waheed, Simcha Pollack, Marguerite Roth, Nathaniel Reichek, Alan Guerci, Jie J Cao
BACKGROUND AND AIMS: The efficacy of statin therapy remains unknown in patients eligible for statin therapy with and without elevated coronary calcium score (CAC). The study sought to evaluate how cardiovascular risk factors, expressed in terms of statin eligibility for primary prevention, and CAC modify clinical outcomes with and without statin therapy. METHODS: We conducted a post-hoc analysis of the St. Francis Heart Study treatment trial, a double-blind, placebo-controlled randomized controlled trial of atorvastatin (20 mg), vitamin C (1 g), and vitamin E (1000 U) daily, versus placebos in 990 asymptomatic individuals with CAC ≥ 80th percentile for age and gender...
December 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27554755/progressive-ms-alliance-industry-forum-maximizing-collective-impact-to-enable-drug-development
#9
P Zaratin, G Comi, T Coetzee, K Ramsey, K Smith, A Thompson, M Panzara
The Progressive MS Alliance Industry Forum describes a new approach to address barriers to developing treatments for progressive multiple sclerosis (MS). This innovative model promises to facilitate robust collaboration between industry, academia, and patient organizations and accelerate research towards the overarching goal of developing safe and effective treatments for progressive MS.
October 2016: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/27554017/inter-trabecular-angle-a-parameter-of-trabecular-bone-architecture-in-the-human-proximal-femur-that-reveals-underlying-topological-motifs
#10
Natalie Reznikov, Hila Chase, Yehonatan Ben Zvi, Victoria Tarle, Matthew Singer, Vlad Brumfeld, Ron Shahar, Steve Weiner
UNLABELLED: Trabecular bone is an intricate 3D network of struts and plates. Although the structure-function relations in trabecular bone have been studied since the time of Julius Wolff, controversy still exists regarding the architectural parameters responsible for its stability and resilience. We present a parameter that measures the angle between two connected trabeculae - the Inter-Trabecular Angle (ITA). We studied the ITA values derived from μCT scans of different regions of the proximal femora of 5 individuals of different age and sex...
October 15, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27417248/maternal-anxiety-and-children-s-laboratory-pain-the-mediating-role-of-solicitousness
#11
Subhadra Evans, Laura A Payne, Laura Seidman, Kirsten Lung, Lonnie Zeltzer, Jennie C I Tsao
There has been limited empirical examination of how parent variables such as anxiety and solicitousness collectively impact child pain response. We sought to examine the relationships among maternal anxiety, solicitous parenting, and children's laboratory anxiety and pain intensity in children with chronic pain. Participants included 80 children and adolescents (ages 8-18) with chronic pain and their mothers. Children completed questionnaires and lab pain tasks measuring their parents' solicitous parenting, pressure, cold and heat pain anticipatory anxiety and pain intensity...
2016: Children
https://www.readbyqxmd.com/read/27371726/molecular-profile-of-tumor-specific-cd8-t-cell-hypofunction-in-a-transplantable-murine-cancer-model
#12
Katherine A Waugh, Sonia M Leach, Brandon L Moore, Tullia C Bruno, Jonathan D Buhrman, Jill E Slansky
Mechanisms of self-tolerance often result in CD8(+) tumor-infiltrating lymphocytes (TIL) with a hypofunctional phenotype incapable of tumor clearance. Using a transplantable colon carcinoma model, we found that CD8(+) T cells became tolerized in <24 h in an established tumor environment. To define the collective impact of pathways suppressing TIL function, we compared genome-wide mRNA expression of tumor-specific CD8(+) T cells from the tumor and periphery. Notably, gene expression induced during TIL hypofunction more closely resembled self-tolerance than viral exhaustion...
August 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27216703/photo-induced-halide-redistribution-in-organic-inorganic-perovskite-films
#13
Dane W deQuilettes, Wei Zhang, Victor M Burlakov, Daniel J Graham, Tomas Leijtens, Anna Osherov, Vladimir Bulović, Henry J Snaith, David S Ginger, Samuel D Stranks
Organic-inorganic perovskites such as CH3NH3PbI3 are promising materials for a variety of optoelectronic applications, with certified power conversion efficiencies in solar cells already exceeding 21%. Nevertheless, state-of-the-art films still contain performance-limiting non-radiative recombination sites and exhibit a range of complex dynamic phenomena under illumination that remain poorly understood. Here we use a unique combination of confocal photoluminescence (PL) microscopy and chemical imaging to correlate the local changes in photophysics with composition in CH3NH3PbI3 films under illumination...
2016: Nature Communications
https://www.readbyqxmd.com/read/27135542/neighborhood-and-home-food-environment-and-children-s-diet-and-obesity-evidence-from-military-personnel-s-installation-assignment
#14
Victoria Shier, Nancy Nicosia, Ashlesha Datar
Research and policy initiatives are increasingly focused on the role of neighborhood food environment in children's diet and obesity. However, existing evidence relies on observational data that is limited by neighborhood selection bias. The Military Teenagers' Environments, Exercise, and Nutrition Study (M-TEENS) leverages the quasi-random variation in neighborhood environment generated by military personnel's assignment to installations to examine whether neighborhood food environments are associated with children's dietary behaviors and BMI...
June 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/27064064/national-g6pd-neonatal-screening-program-in-gaza-strip-of-palestine-rationale-challenges-and-recommendations
#15
REVIEW
M M Sirdah, M S Al-Kahlout, N S Reading
Congenital genetic disorders affecting neonates or young children can have serious clinical consequences if undiagnosed and left untreated. Early detection and an accurate diagnosis are, therefore, of major importance for preventing negative patient outcomes. Even though the occurrence of each specific metabolic disorder may be rare, their collective impact of preventable complications may be of considerable importance to the public health. Our previous studies showed that glucose-6-phosphate dehydrogenase (G6PD) deficiency is a problem of public health importance that has been shown to be a predominant cause of acute hemolytic anemia requiring hospitalization in Palestinian young children in Gaza Strip...
September 2016: Clinical Genetics
https://www.readbyqxmd.com/read/27053088/impact-of-infection-prevention-and-control-initiatives-on-acute-respiratory-infections-in-a-pediatric-long-term-care-facility
#16
Meghan T Murray, Olivia Jackson, Bevin Cohen, Gordon Hutcheon, Lisa Saiman, Elaine Larson, Natalie Neu
We evaluated the collective impact of several infection prevention and control initiatives aimed at reducing acute respiratory infections (ARIs) in a pediatric long-term care facility. ARIs did not decrease overall, though the proportion of infections associated with outbreaks and average number of cases per outbreak decreased. Influenza rates decreased significantly. Infect Control Hosp Epidemiol 2016;37:859-862.
July 2016: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/26980127/prevention-of-youth-violence-a-public-health-approach
#17
REVIEW
Aradhana Bela Sood, Steven J Berkowitz
The causes of youth violence are multifactorial and include biological, individual, familial, social, and economic factors. The influence of parents, family members, and important adults can shape the beliefs of the child toward violence in a significant manner. However, the influence of school and the neighborhood also have an important role in attitudes and behaviors of children toward violence. The complexity of factors related to violence requires a comprehensive public health approach. This article focuses on evidence-based models of intervention to reduce violence while emphasizing collective impact as a guiding principle...
April 2016: Child and Adolescent Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/26963183/building-an-evidence-based-multitiered-system-of-supports-for-high-risk-youth-and-communities
#18
Beverly E Kingston, Sharon F Mihalic, Eric J Sigel
The mental, emotional and behavioral health problems of high-risk youth and youth living in high-risk communities are not inevitable and can be prevented. A shift from the nation's focus on treating disease and illness after it occurs to a concentrated effort on preventing the root causes of these problems is needed. Prevention science suggests a comprehensive multitiered approach that provides evidence-based prevention supports for children and youth at each developmental stage and across multiple social contexts is likely to result in the greatest health impact and return on investment...
March 2016: American Journal of Orthopsychiatry
https://www.readbyqxmd.com/read/26959270/community-vision-and-interagency-alignment-a-community-planning-process-to-promote-active-transportation
#19
Sarah Timmins DeGregory, Nupur Chaudhury, Patrick Kennedy, Philip Noyes, Aletha Maybank
In 2010, the Brooklyn Active Transportation Community Planning Initiative launched in 2 New York City neighborhoods. Over a 2-year planning period, residents participated in surveys, school and community forums, neighborhood street assessments, and activation events-activities that highlighted the need for safer streets locally. Consensus among residents and key multisectoral stakeholders, including city agencies and community-based organizations, was garnered in support of a planned expansion of bicycling infrastructure...
April 2016: American Journal of Public Health
https://www.readbyqxmd.com/read/26853198/developing-a-sustainable-model-of-oral-health-care-for-disadvantaged-aboriginal-people-living-in-rural-and-remote-communities-in-nsw-using-collective-impact-methodology
#20
Kylie Gwynne, Michelle J Irving, Debbie McCowen, Boe Rambaldini, John Skinner, Steve Naoum, Anthony Blinkhorn
A sustainable model of oral health care for disadvantaged Aboriginal people living in rural and remote communities in New South Wales was developed using collective impact methodology. Collective impact is a structured process which draws together organizations to develop a shared agenda and design solutions which are jointly resourced, measured and reported upon.
2016: Journal of Health Care for the Poor and Underserved
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