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https://www.readbyqxmd.com/read/28440796/the-importance-of-international-collaboration-for-rare-diseases-research-a-european-perspective
#1
REVIEW
D Julkowska, C P Austin, C M Cutillo, D Gancberg, C Hager, J Halftermeyer, A H Jonker, L P L Lau, I Norstedt, A Rath, R Schuster, E Simelyte, S van Weely
Over the last two decades, important contributions were made at national, European and international levels to foster collaboration into rare diseases research. The European Union (EU) has put much effort into funding rare diseases research, encouraging national funding organizations to collaborate together in the E-Rare programme, setting up European Reference Networks for rare diseases and complex conditions, and initiating the International Rare Diseases Research Consortium (IRDiRC) together with the National Institutes of Health in the USA...
April 25, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28439181/perspective-hope-for-health-equity
#2
EDITORIAL
George Rust
Times like these test the soul. We are now working for health equity in a time of overt, aggressive opposition. Yet, hope in the face of overwhelming obstacles is the force that has driven most of the world's progress toward equity and justice. Operationalizing real-world hope requires an affirmative vision, an expectation of success, broad coalitions taking action cohesively, and frequent measures of collective impact to drive rapid-cycle improvement.
2017: Ethnicity & Disease
https://www.readbyqxmd.com/read/28357075/de-novo-systemic-deleterious-amino-acid-substitutions-are-common-in-large-cytoskeleton-related-protein-coding-regions
#3
Rebecca J Stoll, Grace R Thompson, Mohammad D Samy, George Blanck
Human mutagenesis is largely random, thus large coding regions, simply on the basis of probability, represent relatively large mutagenesis targets. Thus, we considered the possibility that large cytoskeletal-protein related coding regions (CPCRs), including extra-cellular matrix (ECM) coding regions, would have systemic nucleotide variants that are not present in common SNP databases. Presumably, such variants arose recently in development or in recent, preceding generations. Using matched breast cancer and blood-derived normal datasets from the cancer genome atlas, CPCR single nucleotide variants (SNVs) not present in the All SNPs(142) or 1000 Genomes databases were identified...
February 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28333598/achieving-health-equity-through-community-engagement-in-translating-evidence-to-policy-the-san-francisco-health-improvement-partnership-2010-2016
#4
Kevin Grumbach, Roberto A Vargas, Paula Fleisher, Tomás J Aragón, Lisa Chung, Colleen Chawla, Abbie Yant, Estela R Garcia, Amor Santiago, Perry L Lang, Paula Jones, Wylie Liu, Laura A Schmidt
BACKGROUND: The San Francisco Health Improvement Partnership (SFHIP) promotes health equity by using a novel collective impact model that blends community engagement with evidence-to-policy translational science. The model involves diverse stakeholders, including ethnic-based community health equity coalitions, the local public health department, hospitals and health systems, a health sciences university, a school district, the faith community, and others sectors. COMMUNITY CONTEXT: We report on 3 SFHIP prevention initiatives: reducing consumption of sugar sweetened beverages (SSBs), regulating retail alcohol sales, and eliminating disparities in children's oral health...
March 23, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28276913/postural-stability-clicker-reaction-time-and-bow-draw-force-predict-performance-in-elite-recurve-archery
#5
Wayne Spratford, Rhiannon Campbell
Recurve archery is an Olympic sport that requires extreme precision, upper body strength and endurance. The purpose of this research was to quantify how postural stability variables both pre- and post-arrow release, draw force, flight time, arrow length and clicker reaction time, collectively, impacted on the performance or scoring outcomes in elite recurve archery athletes. Thirty-nine elite-level recurve archers (23 male and 16 female; mean age = 24.7 ± 7.3 years) from four different countries volunteered to participate in this study prior to competing at a World Cup event...
February 14, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28209143/collaborative-leadership-and-the-implementation-of-community-based-fall-prevention-initiatives-a-multiple-case-study-of-public-health-practice-within-community-groups
#6
Maureen Markle-Reid, Cathy Dykeman, Jenny Ploeg, Caralyn Kelly Stradiotto, Angela Andrews, Susan Bonomo, Sarah Orr-Shaw, Niyati Salker
BACKGROUND: Falls among community-dwelling older adults are a serious public health concern. While evidence-based fall prevention strategies are available, their effective implementation requires broad cross-sector coordination that is beyond the capacity of any single institution or organization. Community groups comprised of diverse stakeholders that include public health, care providers from the public and private sectors and citizen volunteers are working to deliver locally-based fall prevention...
February 16, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28178900/influence-of-study-design-variables-on-clinical-pathology-data
#7
Adam Aulbach, Anne Provencher, Niraj Tripathi
A number of factors related to study design have the potential to impact clinical pathology test results during the conduct of nonclinical safety studies. A thorough understanding of these factors is paramount in drawing accurate conclusions from clinical pathology data generated during such studies, particularly when attempting to make the distinction between test article and nontest article-related effects. Study design and conduct variables with potential to impact clinical pathology data discussed in this overview include those related to species and test system, animal age, animal care and husbandry practices, fasting, acclimatization periods, effects of transportation and stressors, route of administration, effects of in-life and surgical procedures, influence of study length, timing of blood collections, impact of vehicle/formulation composition, and some general concepts related to drug class...
February 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/28086863/exercise-mediated-protection-of-diabetic-heart-through-modulation-of-microrna-mediated-molecular-pathways
#8
REVIEW
Jason Kar Sheng Lew, James T Pearson, Daryl O Schwenke, Rajesh Katare
Hyperglycaemia, hypertension, dyslipidemia and insulin resistance collectively impact on the myocardium of people with diabetes, triggering molecular, structural and myocardial abnormalities. These have been suggested to aggravate oxidative stress, systemic inflammation, myocardial lipotoxicity and impaired myocardial substrate utilization. As a consequence, this leads to the development of a spectrum of cardiovascular diseases, which may include but not limited to coronary endothelial dysfunction, and left ventricular remodelling and dysfunction...
January 13, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28050803/access-to-controlled-medicines-for-anesthesia-and-surgical-care-in-low-income-countries-a-narrative-review-of-international-drug-control-systems-and-policies
#9
Jason W Nickerson, Katherine Pettus, Kathleen E Wheeler, Christopher Hallam, David R Bewley-Taylor, Amir Attaran, Adrian W Gelb
PURPOSE: This article describes the functioning of the international drug control system, its integration into national legislation and policy, and the collective impact on access to medicines. SOURCE: We conducted a review of the three international drug control conventions, peer-reviewed articles, and grey literature known to the authors that describes national and international drug control systems and their impact on access to controlled medicines. This review was supplemented with literature derived from a structured search of MEDLINE(®) for articles relating to medical uses of ketamine in low- and middle-income countries conducted to strengthen an advocacy campaign...
March 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/27981189/untangling-the-gordian-knot-of-hiv-stress-and-cognitive-impairment
#10
REVIEW
Arielle N Valdez, Leah H Rubin, Gretchen N Neigh
As individuals live longer with HIV, this "graying of the HIV epidemic" has introduced a new set of challenges including a growing number of age and inflammation-related diseases such as cardiovascular disease, type II diabetes, cancer, and dementia. The biological underpinnings of these complex and co-morbid diseases are not fully understood and become very difficult to disentangle in the context of HIV and aging. In the current review we examine the contributions and interactions of HIV, stress, and cognitive impairment and query the extent to which inflammation is the linchpin in these dynamic interactions...
October 2016: Neurobiology of Stress
https://www.readbyqxmd.com/read/27977295/research-progress-in-tofu-processing-from-raw-materials-to-processing-conditions
#11
Qing Zhang, Chenzhi Wang, Bokang Li, Lin Li, Derong Lin, Hong Chen, Yaowen Liu, Suqing Li, Wen Qin, Jiang Liu, Weiguo Liu, Wenyu Yang
As a traditional soybean product with good quality and a healthy food with many functional components, tofu is increasingly consumed in people's daily life. Traditional tofu processing consists of numerous steps, including the soaking and grinding of soybean seeds, heating of the soybean slurry, filtering, and addition of coagulants, and others. The properties of soybean seeds, processing scale, soaking and heating conditions, type and concentration of coagulant and other factors collectively impact the processing steps and the final tofu quality...
December 15, 2016: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/27878353/does-mri-of-the-thoracolumbar-spine-change-management-in-blunt-trauma-patients-with-stable-thoracolumbar-spinal-injuries-without-neurologic-deficits
#12
Paul Deramo, Vaidehi Agrawal, Joseph Amos, Nimesh Patel, Henry Jefferson
BACKGROUND: In blunt trauma patients with computed tomography (CT) findings of stable thoracolumbar (TL) spinal injury without neurologic deficits, magnetic resonance imaging (MRI) studies are commonly obtained, though the impact on overall management remains unclear. The indication for MRI in patients with TL injury without neurologic deficits continues to remain unclear. Here, we evaluate the role of MRI on clinical management of patients presenting with this diagnosis. METHODS: After IRB approval, all registry patients from December 2005 to December 2015 with all blunt TL injuries without defects were extracted...
November 22, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27768558/developing-indicators-for-evaluation-of-age-friendly-communities-in-canada-process-and-results
#13
H Orpana, M Chawla, E Gallagher, E Escaravage
INTRODUCTION: In 2006, the World Health Organization launched the Global Age-Friendly Cities Project to support active aging. Canada has a large number of age-friendly initiatives; however, little is known about the effectiveness and outcomes of age-friendly community (AFC) initiatives. In addition, stakeholders report that they lack the capacity and tools to develop and conduct evaluations of their AFC initiatives. In order to address these gaps, the Public Health Agency of Canada developed indicators to support the evaluation of AFC initiatives relevant to a wide range of Canadian communities...
October 2016: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/27763428/developing-a-sustainable-model-of-oral-health-care-for-disadvantaged-aboriginal-people-living-in-rural-and-remote-communities-in-nsw-using-collective-impact-methodology
#14
Kylie Gwynne, Michelle J Irving, Debbie McCowen, Boe Rambaldini, John Skinner, Steve Naoum, Anthony Blinkhorn
A sustainable model of oral health care for disadvantaged Aboriginal people living in rural and remote communities in New South Wales was developed using collective impact methodology. Collective impact is a structured process which draws together organizations to develop a shared agenda and design solutions which are jointly resourced, measured and reported upon.
2016: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/27693004/collective-impact-of-conventional-cardiovascular-risk-factors-and-coronary-calcium-score-on-clinical-outcomes-with-or-without-statin-therapy-the-st-francis-heart-study
#15
Salman Waheed, Simcha Pollack, Marguerite Roth, Nathaniel Reichek, Alan Guerci, Jie J Cao
BACKGROUND AND AIMS: The efficacy of statin therapy remains unknown in patients eligible for statin therapy with and without elevated coronary calcium score (CAC). The study sought to evaluate how cardiovascular risk factors, expressed in terms of statin eligibility for primary prevention, and CAC modify clinical outcomes with and without statin therapy. METHODS: We conducted a post-hoc analysis of the St. Francis Heart Study treatment trial, a double-blind, placebo-controlled randomized controlled trial of atorvastatin (20 mg), vitamin C (1 g), and vitamin E (1000 U) daily, versus placebos in 990 asymptomatic individuals with CAC ≥ 80th percentile for age and gender...
December 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27554755/progressive-ms-alliance-industry-forum-maximizing-collective-impact-to-enable-drug-development
#16
P Zaratin, G Comi, T Coetzee, K Ramsey, K Smith, A Thompson, M Panzara
The Progressive MS Alliance Industry Forum describes a new approach to address barriers to developing treatments for progressive multiple sclerosis (MS). This innovative model promises to facilitate robust collaboration between industry, academia, and patient organizations and accelerate research towards the overarching goal of developing safe and effective treatments for progressive MS.
October 2016: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/27554017/inter-trabecular-angle-a-parameter-of-trabecular-bone-architecture-in-the-human-proximal-femur-that-reveals-underlying-topological-motifs
#17
Natalie Reznikov, Hila Chase, Yehonatan Ben Zvi, Victoria Tarle, Matthew Singer, Vlad Brumfeld, Ron Shahar, Steve Weiner
UNLABELLED: Trabecular bone is an intricate 3D network of struts and plates. Although the structure-function relations in trabecular bone have been studied since the time of Julius Wolff, controversy still exists regarding the architectural parameters responsible for its stability and resilience. We present a parameter that measures the angle between two connected trabeculae - the Inter-Trabecular Angle (ITA). We studied the ITA values derived from μCT scans of different regions of the proximal femora of 5 individuals of different age and sex...
October 15, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27417248/maternal-anxiety-and-children-s-laboratory-pain-the-mediating-role-of-solicitousness
#18
Subhadra Evans, Laura A Payne, Laura Seidman, Kirsten Lung, Lonnie Zeltzer, Jennie C I Tsao
There has been limited empirical examination of how parent variables such as anxiety and solicitousness collectively impact child pain response. We sought to examine the relationships among maternal anxiety, solicitous parenting, and children's laboratory anxiety and pain intensity in children with chronic pain. Participants included 80 children and adolescents (ages 8-18) with chronic pain and their mothers. Children completed questionnaires and lab pain tasks measuring their parents' solicitous parenting, pressure, cold and heat pain anticipatory anxiety and pain intensity...
2016: Children
https://www.readbyqxmd.com/read/27371726/molecular-profile-of-tumor-specific-cd8-t-cell-hypofunction-in-a-transplantable-murine-cancer-model
#19
Katherine A Waugh, Sonia M Leach, Brandon L Moore, Tullia C Bruno, Jonathan D Buhrman, Jill E Slansky
Mechanisms of self-tolerance often result in CD8(+) tumor-infiltrating lymphocytes (TIL) with a hypofunctional phenotype incapable of tumor clearance. Using a transplantable colon carcinoma model, we found that CD8(+) T cells became tolerized in <24 h in an established tumor environment. To define the collective impact of pathways suppressing TIL function, we compared genome-wide mRNA expression of tumor-specific CD8(+) T cells from the tumor and periphery. Notably, gene expression induced during TIL hypofunction more closely resembled self-tolerance than viral exhaustion...
August 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27216703/photo-induced-halide-redistribution-in-organic-inorganic-perovskite-films
#20
Dane W deQuilettes, Wei Zhang, Victor M Burlakov, Daniel J Graham, Tomas Leijtens, Anna Osherov, Vladimir Bulović, Henry J Snaith, David S Ginger, Samuel D Stranks
Organic-inorganic perovskites such as CH3NH3PbI3 are promising materials for a variety of optoelectronic applications, with certified power conversion efficiencies in solar cells already exceeding 21%. Nevertheless, state-of-the-art films still contain performance-limiting non-radiative recombination sites and exhibit a range of complex dynamic phenomena under illumination that remain poorly understood. Here we use a unique combination of confocal photoluminescence (PL) microscopy and chemical imaging to correlate the local changes in photophysics with composition in CH3NH3PbI3 films under illumination...
2016: Nature Communications
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