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https://www.readbyqxmd.com/read/29246113/comparison-of-weighting-approaches-for-genetic-risk-scores-in-gene-environment-interaction-studies
#1
Anke Hüls, Ursula Krämer, Christopher Carlsten, Tamara Schikowski, Katja Ickstadt, Holger Schwender
BACKGROUND: Weighted genetic risk scores (GRS), defined as weighted sums of risk alleles of single nucleotide polymorphisms (SNPs), are statistically powerful for detection gene-environment (GxE) interactions. To assign weights, the gold standard is to use external weights from an independent study. However, appropriate external weights are not always available. In such situations and in the presence of predominant marginal genetic effects, we have shown in a previous study that GRS with internal weights from marginal genetic effects ("GRS-marginal-internal") are a powerful and reliable alternative to single SNP approaches or the use of unweighted GRS...
December 16, 2017: BMC Genetics
https://www.readbyqxmd.com/read/29225195/strengthening-integration-of-clinical-and-public-health-systems-to-prevent-maternal-child-obesity-in-the-first-1-000days-a-collective-impact-approach
#2
Tiffany Blake-Lamb, Alexy Arauz Boudreau, Sarah Matathia, Etna Tiburcio, Meghan E Perkins, Brianna Roche, Milton Kotelchuck, Derri Shtasel, Sarah N Price, Elsie M Taveras
INTRODUCTION: Obesity interventions may be most effective if they begin in the earliest stages of life, support changes across family, clinical, and public health systems, and address socio-contextual factors. METHODS: The First 1000Days is a systematic program starting in early pregnancy lasting through the first 24months of infancy to prevent obesity among low-income mother-infant pairs in three community health centers in Massachusetts. The program uses a Collective Impact approach to create the infrastructure for sustained, system-wide changes for obesity prevention across early life clinical and public health services, including Obstetrics, Pediatrics, Adult Medicine, Behavioral Health, Nutrition, Community Health, the Women, Infants and Children (WIC) program, and the Maternal, Infant and Childhood Home Visiting program...
December 7, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29189500/innovative-methods-for-designing-actionable-program-evaluation
#3
Brandon Nesbit, Marci Hertz, Sally Thigpen, Ted Castellanos, Michelle Brown, Jamila Porter, Amber Williams
CONTEXT: For most programs, whether funded through governmental agencies or nongovernmental organizations, demonstrating the impact of implemented activities is vital to ensuring continued funding and support. OBJECTIVE: Program evaluation is a critical tool that serves the dual purpose of describing impact and identifying areas for program improvement. From a funder's perspective, describing the individual and collective impact of state-based programs can be challenging due to variations in strategies being implemented and types of data being collected...
January 2018: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/29177607/building-healthy-start-grantees-capacity-to-achieve-collective-impact-lessons-from-the-field
#4
Kimberly Bradley, Karuna S Chibber, Naima Cozier, Peggy Vander Meulen, Colleen Ayres-Griffin
Purpose While Healthy Start has emphasized the need for multi-sectorial community engagement and collaboration since its inception, in 2014 Healthy Start adopted Collective Impact (CI) as a framework for reducing infant mortality. This paper describes the development of a peer-focused capacity-building strategy that introduced key elements of CI and preliminary findings of Healthy Start grantees' progress with using CI as an approach to collaboration. Description The Collective Impact Peer Learning Networks (CI-PLNs) consisted of eight 90-min virtual monthly meetings and one face-to-face session that reviewed CI pre-conditions and conditions...
November 24, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29168161/a-multilevel-approach-to-breastfeeding-promotion-using-healthy-start-to-deliver-individual-support-and-drive-collective-impact
#5
Chelsey Leruth, Jacqueline Goodman, Brian Bragg, Dara Gray
Purpose Breastfeeding has been linked to a host of positive health effects for women and children. However, disparities in breastfeeding initiation and duration prevent many low-income and African-American women from realizing these benefits. Existing breastfeeding promotion efforts often do not reach women who need support the most. In response, the Westside Healthy Start program (WHS), located in Chicago, Illinois, developed an ongoing multilevel approach to breastfeeding promotion. Description Key elements of our WHS breastfeeding model include individual education and counseling from pregnancy to 6 months postpartum and partnership with a local safety-net hospital to implement the Baby-Friendly Hospital Initiative and provide lactation support to delivering patients...
November 22, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29159966/interrogating-marine-virus-host-interactions-and-elemental-transfer-with-boncat-and-nanosims-based-methods
#6
Alexis L Pasulka, Kimberlee Thamatrakoln, Sebastian H Kopf, Yunbin Guan, Bonnie Poulos, Annie Moradian, Michael J Sweredoski, Sonja Hess, Mathew B Sullivan, Kay D Bidle, Victoria J Orphan
While the collective impact of marine viruses has become more apparent over the last decade, a deeper understanding of virus-host dynamics and the role of viruses in nutrient cycling would benefit from direct observations at the single-virus level. We describe two new complementary approaches - stable isotope probing coupled with nanoscale secondary ion mass spectrometry (nanoSIMS) and fluorescence-based biorthogonal non-canonical amino acid tagging (BONCAT) - for studying the activity and biogeochemical influence of marine viruses...
November 21, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/29129805/rare-genetic-diseases-update-on-diagnosis-treatment-and-online-resources
#7
REVIEW
Robert E Pogue, Denise P Cavalcanti, Shreya Shanker, Rosangela V Andrade, Lana R Aguiar, Juliana L de Carvalho, Fabrício F Costa
Rare genetic diseases collectively impact a significant portion of the world's population. For many diseases there is limited information available, and clinicians can find difficulty in differentiating between clinically similar conditions. This leads to problems in genetic counseling and patient treatment. The biomedical market is affected because pharmaceutical and biotechnology industries do not see advantages in addressing rare disease treatments, or because the cost of the treatments is too high. By contrast, technological advances including DNA sequencing and analysis, together with computer-aided tools and online resources, are allowing a more thorough understanding of rare disorders...
November 10, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/29103638/collaborative-efforts-collective-impact
#8
Linda R Greene, Sara Cosgrove
No abstract text is available yet for this article.
October 24, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/29100497/the-macro-economic-determinants-of-health-and-health-inequalities-umbrella-review-protocol
#9
Yannish Naik, Peter Baker, Ian Walker, Taavi Tillmann, Kristin Bash, Darryl Quantz, Frances Hillier-Brown, Clare Bambra
BACKGROUND: The economic determinants of health have been widely recognised as crucial factors affecting health; however, to date, no comprehensive review has been undertaken to summarise these factors and the ways in which they can influence health. We conceptualise the economy as a complex system made up of underlying approaches, regulation from institutions, markets, finance, labour, the public-private balance as well as production and distributional effects, which collectively impact on health through the effect of moderators...
November 3, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29097731/temporal-consistency-between-gross-primary-production-and-solar-induced-chlorophyll-fluorescence-in-the-ten-most-populous-megacity-areas-over-years
#10
Yaoping Cui, Xiangming Xiao, Yao Zhang, Jinwei Dong, Yuanwei Qin, Russell B Doughty, Geli Zhang, Jie Wang, Xiaocui Wu, Yaochen Qin, Shenghui Zhou, Joanna Joiner, Berrien Moore
The gross primary production (GPP) of vegetation in urban areas plays an important role in the study of urban ecology. It is difficult however, to accurately estimate GPP in urban areas, mostly due to the complexity of impervious land surfaces, buildings, vegetation, and management. Recently, we used the Vegetation Photosynthesis Model (VPM), climate data, and satellite images to estimate the GPP of terrestrial ecosystems including urban areas. Here, we report VPM-based GPP (GPPvpm) estimates for the world's ten most populous megacities during 2000-2014...
November 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29070711/dietary-b-vitamin-intake-is-associated-with-lower-urinary-monomethyl-arsenic-and-oxidative-stress-marker-15-f2t-isoprostane-among-new-hampshire-adults
#11
Caitlin G Howe, Zhigang Li, Michael S Zens, Thomas Palys, Yu Chen, Jacqueline Y Channon, Margaret R Karagas, Shohreh F Farzan
Background: Arsenic exposure has been associated with an increased risk of cardiovascular disease (CVD). Growing evidence suggests that B vitamins facilitate arsenic metabolism and may protect against arsenic toxicity. However, to our knowledge, few studies have evaluated this in US populations.Objective: Our objective was to examine whether higher B vitamin intake is associated with enhanced arsenic metabolism and lower concentrations of preclinical markers of CVD among New Hampshire adults.Methods: We used weighted quantile sum (WQS) regression to evaluate the collective impact of 6 dietary B vitamins (thiamin, riboflavin, folate, niacin, and vitamins B-6 and B-12) on 1) the proportion of arsenic metabolites in urine and 2) 6 CVD-related markers [including urinary 15-F2t-isoprostane (15-F2t-IsoP)] among 418 participants (26-75 y of age) from the New Hampshire Health Study...
December 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28961647/four-states-four-projects-one-mission-collectively-enhancing-mental-and-behavioral-health-capacity-throughout-the-gulf-coast
#12
Jennifer Langhinrichsen-Rohling, Howard Osofsky, Joy Osofsky, Glenn Rohrer, Timothy Rehner
CONTEXT: The 2010 Deepwater Horizon oil spill triggered numerous concerns regarding the health and well-being of citizens within the already vulnerable Gulf Coast region. Four Mental and Behavioral Health Capacity Projects (MBHCPs) united to form the Quad-State MBHCP component of the Gulf Region Health Outreach Program (GRHOP). Their shared mission was to increase mental and behavioral health (MBH) capacity within coastal counties of Louisiana, Mississippi, Alabama, and the Florida Panhandle...
November 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28918649/characterizing-verified-head-impacts-in-high-school-girls-lacrosse
#13
Shane V Caswell, Andrew E Lincoln, Hannah Stone, Patricia Kelshaw, Margot Putukian, Lisa Hepburn, Michael Higgins, Nelson Cortes
BACKGROUND: Girls' high school lacrosse players have higher rates of head and facial injuries than boys. Research indicates that these injuries are caused by stick, player, and ball contacts. Yet, no studies have characterized head impacts in girls' high school lacrosse. PURPOSE: To characterize girls' high school lacrosse game-related impacts by frequency, magnitude, mechanism, player position, and game situation. STUDY DESIGN: Descriptive epidemiology study...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28853640/health-system-redesign-using-collective-impact-implementation-of-the-behavioural-supports-ontario-initiative-in-southwest-ontario
#14
Iris Gutmanis, Jennifer Speziale, Loretta M Hillier, Elisabeth van Bussel, Julie Girard, Kelly Simpson
This paper describes how the Collective Impact framework facilitated the design, implementation and development of a quality improvement initiative aimed at changing the way healthcare is provided to older adults living with mental health, addictions, neurocognitive and behavioral issues in southwestern Ontario. By promoting a common agenda, shared measurement systems, mutually reinforcing activities, continuous communication and with leadership from a backbone organization, system-wide change occurred. Outcomes, operational/strategic, clinical, capacity enhancement and community support structures as well as challenges are discussed...
August 30, 2017: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/28812843/collaboration-between-researchers-and-knowledge-users-in-health-technology-assessment-a-qualitative-exploratory-study
#15
Mylène Tantchou Dipankui
BACKGROUND: Collaboration between researchers and knowledge users is increasingly promoted because it could enhance more evidence-based decision-making and practice. These complex relationships differ in form, in the particular goals they are trying to achieve, and in whom they bring together. Although much is understood about why partnerships form, relatively little is known about how collaboration works: how the collaborative process is shaped through the partners' interactions, especially in the field of health technology assessment (HTA)? This study aims at addressing this gap in the literature in the specific context of HTA...
December 16, 2016: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28805502/the-fundamentals-of-cross-sector-collaboration-for-social-change-to-promote-population-health
#16
Joanne G de Montigny, Sylvie Desjardins, Louise Bouchard
Cross-sector collaboration is increasingly relied upon to tackle society's pressing and intractable problems. Chief among societal problems are unfavorable structural and social determinants of health. The ability to positively change these health determinants rests on the collaborative processes and structures of governance across diverse sectors in society. The purpose of this article is to present a conceptual framework that sheds light on the basic requirements of cross-sector collaboration for social change to promote the health of populations...
August 1, 2017: Global Health Promotion
https://www.readbyqxmd.com/read/28804051/development-and-validation-of-a-novel-scale-for-measuring-interpersonal-factors-underlying-injection-drug-using-behaviours-among-injecting-partnerships
#17
Meghan D Morris, Torsten B Neilands, Erin Andrew, Lisa Maher, Kimberly A Page, Judith A Hahn
BACKGROUND: People who inject drugs with sexual partners or close friends have high rates of syringe/ancillary equipment sharing and HIV and hepatitis C virus (HCV) infection. Although evidence suggests that interpersonal factors underlie these higher risk profiles, there is no quantitative measure of how interpersonal factors operate within injecting relationships. We aimed to develop and validate a quantitative scale to assess levels of injecting drug-related interpersonal factors associated with risky injecting behaviours within injecting partnerships...
October 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28724679/improving-health-outcomes-in-a-rural-community-roanoke-valley-community-health-initiative
#18
Audrey L Hardy, Melissa Haithcox-Dennis
For the past 7 years, The Roanoke Valley Community Health Initiative has made inroads in the fight against obesity in Halifax County. The group has leveraged valuable resources to maximize collective impact in the Roanoke Valley. The Health Initiative's work continues to be a catalyst for positive change across the region.
July 2017: North Carolina Medical Journal
https://www.readbyqxmd.com/read/28690564/effects-of-mobile-text-advertising-on-consumer-purchase-intention-a-moderated-mediation-analysis
#19
Lin Hongyan, Chen Zhankui
Mobile shopping is increasing in prevalence and has become a necessary part of many people's daily lives. However, one main channel for mobile shopping, mobile shopping applications (apps), has not been thoroughly investigated. This study focused on mobile text advertising delivered from mobile shopping apps using the intention to purchase as the dependent variable for testing its marketing effect. In the context of a promotion focus vs. a prevention focus, we used Higgins' regulatory focus theory combined with Ajzen's TPB and Herzog's U&G to analyze the mechanism by which consumers formulate an intention to purchase in a mobile advertising context...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28685866/examining-key-stakeholder-and-community-residents-understanding-of-environmental-influences-to-inform-place-based-interventions-to-reduce-obesity-in-rural-communities-kentucky-2015
#20
Alison Gustafson, Margaret McGladrey, Emily Liu, Nicole Peritore, Kelly Webber, Brooke Butterworth, Ann Vail
PURPOSE: Rural residents report high rates of obesity, physical inactivity, and poor eating habits. The objectives of this study were to (1) use the collective impact model to guide efforts to elicit community members' perceptions of county-specific factors influencing high obesity rates; (2) determine the association between utilization of food retail venues and concern about obesity and healthy eating; and (3) determine community members' utilization of physical activity infrastructure and concern about physical inactivity...
July 7, 2017: Journal of Rural Health
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