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Realist evaluation

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https://www.readbyqxmd.com/read/29341587/fucoidan-prolongs-the-circulation-time-of-dextran-coated-iron-oxide-nanoparticles
#1
Maha R A Abdollah, Thomas J Carter, Clare Jones, Tammy L Kalber, Vineeth Rajkumar, Berend Tolner, Cordula Gruettner, May Zaw-Thin, Julia Baguña Torres, Matthew Ellis, Mathew Robson, R Barbara Pedley, Paul Mulholland, Rafael T M de Rosales, Kerry Ann Chester
The magnetic properties and safety of dextran-coated superparamagnetic iron oxide nanoparticles (SPIONs) have facilitated their clinical use as MRI contrast agents and stimulated research on applications for SPIONs in particle imaging and magnetic hyperthermia. The wider clinical potential of SPIONs, however, has been limited by their rapid removal from circulation via the reticuloendothelial system (RES). We explored the possibility of extending SPION circulatory time using fucoidan, a seaweed-derived food supplement, to inhibit RES uptake...
January 17, 2018: ACS Nano
https://www.readbyqxmd.com/read/29340549/teaching-model-for-evaluation-of-the-ability-and-competence-progress-in-endosuture-in-surgical-skill-laboratory
#2
Luiz Gonzaga de Moura-Júnior, Almino Ramos, Josemberg Marins Campos, Álvaro Antônio Ferraz, Hermano Ângelo Lima Rocha, Grijalva Otávio Costa
BACKGROUND: Laparoscopic manual suturing is probably the most difficult skill to be acquired in minimally invasive surgery. However, laparoscopic exercise endo-sutures can be learned with a simulator and are of great practical importance and clinical applicability, absorbing concepts that are immediately transferred to the operating room. AIM: To assess the progression of skills competence in endo-sutures through realistic simulation model of systematized education...
October 2017: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/29337537/microplastic-effect-thresholds-for-freshwater-benthic-macroinvertebrates
#3
Paula E Redondo Hasselerharm, Dede Falahudin, Edwin Peeters, Albert A Koelmans
Now that microplastics have been detected in lakes, rivers and estuaries all over the globe, evaluating their effects on biota has become an urgent research priority. This is the first study that aims at determining the effect thresholds for a battery of six freshwater benthic macroinvertebrates with different species traits, using a wide range of microplastic concentrations. Standardized 28 d single species bioassays were performed under environmentally relevant exposure conditions using polystyrene microplastics (20 - 500 µm) mixed with sediment at concentrations ranging from 0 to 40% sediment dry weight (dw)...
January 16, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29337170/virtual-cerebral-aneurysm-clipping-with-real-time-haptic-force-feedback-in-neurosurgical-education
#4
Matthias Gmeiner, Johannes Dirnberger, Wolfgang Fenz, Maria Gollwitzer, Gabriele Wurm, Johannes Trenkler, Andreas Gruber
OBJECTIVE: Realistic, safe and efficient modalities for simulation-based training are highly warranted to enhance the quality of surgical education and should be incorporated in resident training. The aim of this study was to develop a patient-specific virtual cerebral aneurysm-clipping simulator with haptic force-feedback and real-time deformation of the aneurysm and vessels. METHODS: A prototype simulator was developed from 2012-2016. Evaluation of virtual clipping by blood flow simulation was integrated in this software and the prototype was evaluated by 18 neurosurgeons...
January 11, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29334963/evaluating-the-impact-of-a-falls-prevention-community-of-practice-in-a-residential-aged-care-setting-a-realist-approach
#5
Jacqueline Francis-Coad, Christopher Etherton-Beer, Caroline Bulsara, Nicole Blackburn, Paola Chivers, Anne-Marie Hill
BACKGROUND: Falls are a major socio-economic problem among residential aged care (RAC) populations resulting in high rates of injury including hip fracture. Guidelines recommend that multifactorial prevention strategies are implemented but these require translation into clinical practice. A community of practice (CoP) was selected as a suitable model to support translation of the best available evidence into practice, as it could bring together like-minded people with falls expertise and local clinical knowledge providing a social learning opportunity in the pursuit of a common goal; falls prevention...
January 15, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29334269/effects-of-a-transient-noise-reduction-algorithm-on-speech-intelligibility-in-noise-noise-tolerance-and-perceived-annoyance-in-cochlear-implant-users
#6
J Gertjan Dingemanse, Jantien L Vroegop, André Goedegebure
OBJECTIVE: To evaluate the validity and efficacy of a transient noise reduction algorithm (TNR) in cochlear implant processing and the interaction of TNR with a continuous noise reduction algorithm (CNR). DESIGN: We studied the effects of TNR and CNR on the perception of realistic sound samples with transients, using subjective ratings of annoyance, a speech-in-noise test and a noise tolerance test. STUDY SAMPLE: Participants were 16 experienced cochlear implant recipients wearing an Advanced Bionics Naida Q70 processor...
January 15, 2018: International Journal of Audiology
https://www.readbyqxmd.com/read/29331715/toxicokinetics-of-zn-and-cd-in-the-earthworm-eisenia-andrei-exposed-to-metal-contaminated-soils-under-different-combinations-of-air-temperature-and-soil-moisture-content
#7
M Nazaret González-Alcaraz, Susana Loureiro, Cornelis A M van Gestel
This study evaluated how different combinations of air temperature (20 °C and 25 °C) and soil moisture content (50% and 30% of the soil water holding capacity, WHC), reflecting realistic climate change scenarios, affect the bioaccumulation kinetics of Zn and Cd in the earthworm Eisenia andrei. Earthworms were exposed for 21 d to two metal-contaminated soils (uptake phase), followed by 21 d incubation in non-contaminated soil (elimination phase). Body Zn and Cd concentrations were checked in time and metal uptake (k1) and elimination (k2) rate constants determined; metal bioaccumulation factor (BAF) was calculated as k1/k2...
January 8, 2018: Chemosphere
https://www.readbyqxmd.com/read/29331449/quantifying-axonal-responses-in-patient-specific-models-of-subthalamic-deep-brain-stimulation
#8
Kabilar Gunalan, Bryan Howell, Cameron C McIntyre
Medical imaging has played a major role in defining the general anatomical targets for deep brain stimulation (DBS) therapies. However, specifics on the underlying brain circuitry that is directly modulated by DBS electric fields remain relatively undefined. Detailed biophysical modeling of DBS provides an approach to quantify the theoretical responses to stimulation at the cellular level, and has established a key role for axonal activation in the therapeutic mechanisms of DBS. Estimates of DBS-induced axonal activation can then be coupled with advances in defining the structural connectome of the human brain to provide insight into the modulated brain circuitry and possible correlations with clinical outcomes...
January 10, 2018: NeuroImage
https://www.readbyqxmd.com/read/29330747/recent-advances-in-screening-for-barrett-s-esophagus
#9
REVIEW
Sarmed S Sami, Prasad G Iyer
OPINION STATEMENT: PURPOSE OF REVIEW: There is a pressing need for effective strategies to halt the increase in both the incidence and mortality of esophageal adenocarcinoma (EAC). Screening for Barrett's esophagus, which is the only known precursor of EAC, remains a ripe area for research, particularly with regard to identifying the target population, screening tools, and management of screen-detected populations. This review aims to explore in depth the rationale for screening for Barrett's esophagus, recent biotechnological advances which may have the potential of making screening feasible, and also highlight the challenges which will have to be overcome in order make screening for BE a realistic prospect...
January 13, 2018: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/29324784/multiscale-modelling-of-blood-flow-in-cerebral-microcirculation-details-at-capillary-scale-control-accuracy-at-the-level-of-the-cortex
#10
Myriam Peyrounette, Yohan Davit, Michel Quintard, Sylvie Lorthois
Aging or cerebral diseases may induce architectural modifications in human brain microvascular networks, such as capillary rarefaction. Such modifications limit blood and oxygen supply to the cortex, possibly resulting in energy failure and neuronal death. Modelling is key in understanding how these architectural modifications affect blood flow and mass transfers in such complex networks. However, the huge number of vessels in the human brain-tens of billions-prevents any modelling approach with an explicit architectural representation down to the scale of the capillaries...
2018: PloS One
https://www.readbyqxmd.com/read/29324721/electromagnetic-acoustic-transducers-for-robotic-nondestructive-inspection-in-harsh-environments
#11
Sungho Choi, Hwanjeong Cho, Matthew S Lindsey, Cliff J Lissenden
Elevated temperature, gamma radiation, and geometric constraints inside dry storage casks for spent nuclear fuel represent a harsh environment for nondestructive inspection of the cask and require that the inspection be conducted with a robotic system. Electromagnetic acoustic transducers (EMATs) using non-contact ultrasonic transduction based on the Lorentz force to excite/receive ultrasonic waves are suited for use in the robotic inspection. Periodic permanent magnet EMATs that actuate/receive shear horizontal guided waves are developed for application to robotic nondestructive inspection of stress corrosion cracks in the heat affected zone of welds in stainless steel dry storage canisters...
January 11, 2018: Sensors
https://www.readbyqxmd.com/read/29324567/electronic-health-record-implementation-findings-at-a-large-suburban-health-and-human-services-department
#12
Kenyon Crowley, Anubhuti Mishra, Raul Cruz-Cano, Robert Gold, Dushanka Kleinman, Ritu Agarwal
OBJECTIVE: Evaluate an electronic health record (EHR) implementation across a large public health department to better understand and improve implementation effectiveness of EHRs in public health departments. DESIGN: A survey based on Consolidated Framework for Implementation Research constructs was administered to staff before and after implementation of an EHR. SETTING: Large suburban county department of health and human services that provides clinical, behavioral, social, and oral health services...
January 10, 2018: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/29322186/stuttering-in-preschool-children-direct-versus-indirect-treatment
#13
Marilyn A Nippold
Purpose: The purpose of this article is to discuss the controversial topic of stuttering in preschool children and how to evaluate the options for treatment, emphasizing the role of external research evidence. Method: A hypothetical but realistic case study of a 3-year-old boy who stutters is described. Two contrasting approaches to treatment are presented, the Lidcombe Program (LP) and the demands and capacities model (DCM). Studies published in peer-reviewed research journals that have examined the effectiveness of each approach are summarized and critiqued...
January 9, 2018: Language, Speech, and Hearing Services in Schools
https://www.readbyqxmd.com/read/29322152/computational-exploration-of-fe55-c240-catalyzed-fischer-tropsch-synthesis
#14
Geraldine Cilpa-Karhu, Kari Laasonen
Single-shell carbon-encapsulated iron nanoparticles (SCEINs), Fe@C, have been shown to be charge-transfer complexes that can act as effective catalysts in the hydrogen and oxygen evolution reactions. A new generation of Fe-based catalysts for Fischer-Tropsch synthesis (FTS) which resembles SCEINs, e.g. single carbide nanoparticles encapsulated in carbon shells, has demonstrated enhanced activity and stability for FTS as compared to other carbon-supported Fe-based FTS. Thus the catalytic ability of SCEINs for the water splitting reactions and the Fe-based FTS catalyst with SCEINs-like features stimulated our exploration of SCEINs-catalyzed FTS...
January 11, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29321294/model-recommendations-meet-management-reality-implementation-and-evaluation-of-a-network-informed-vaccination-effort-for-endangered-hawaiian-monk-seals
#15
Stacie J Robinson, Michelle M Barbieri, Samantha Murphy, Jason D Baker, Albert L Harting, Meggan E Craft, Charles L Littnan
Where disease threatens endangered wildlife populations, substantial resources are required for management actions such as vaccination. While network models provide a promising tool for identifying key spreaders and prioritizing efforts to maximize efficiency, population-scale vaccination remains rare, providing few opportunities to evaluate performance of model-informed strategies under realistic scenarios. Because the endangered Hawaiian monk seal could be heavily impacted by disease threats such as morbillivirus, we implemented a prophylactic vaccination programme...
January 10, 2018: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29318469/numerical-simulation-of-ion-transport-in-a-nano-electrospray-ion-source-at-atmospheric-pressure
#16
Wei Wang, Steve Bajic, Benzi John, David R Emerson
Understanding ion transport properties from the ion source to the mass spectrometer (MS) is essential for optimizing device performance. Numerical simulation helps in understanding of ion transport properties and, furthermore, facilitates instrument design. In contrast to previously reported numerical studies, ion transport simulations in a continuous injection mode whilst considering realistic space-charge effects have been carried out. The flow field was solved using Reynolds-averaged Navier-Stokes (RANS) equations, and a particle-in-cell (PIC) method was applied to solve a time-dependent electric field with local charge density...
January 9, 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29316720/on-the-performance-evaluation-of-a-mimo-wcdma-transmission-architecture-for-building-management-systems
#17
Eleftherios Tsampasis, Panagiotis K Gkonis, Panagiotis Trakadas, Theodοre Zahariadis
The goal of this study was to investigate the performance of a realistic wireless sensor nodes deployment in order to support modern building management systems (BMSs). A three-floor building orientation is taken into account, where each node is equipped with a multi-antenna system while a central base station (BS) collects and processes all received information. The BS is also equipped with multiple antennas; hence, a multiple input-multiple output (MIMO) system is formulated. Due to the multiple reflections during transmission in the inner of the building, a wideband code division multiple access (WCDMA) physical layer protocol has been considered, which has already been adopted for third-generation (3G) mobile networks...
January 8, 2018: Sensors
https://www.readbyqxmd.com/read/29315909/seeking-excellence-an-evaluation-of-235-international-laboratories-conducting-water-isotope-analyses-by-isotope-ratio-and-laser-absorption-spectrometer
#18
L I Wassenaar, S Terzer-Wassmuth, C Douence, L Araguas-Araguas, P K Aggarwal, T B Coplen
RATIONALE: Water stable isotope ratios (δ2 H and δ18 O values) are widely used tracers in environmental studies; hence, accurate and precise assays are required for providing sound scientific information. We tested the analytical performance of 235 international laboratories conducting water isotope analyses using dual-inlet and continuous-flow isotope ratio mass spectrometers and laser spectrometers through a water isotope inter-comparison test. METHODS: Eight test water samples were distributed by the IAEA to international stable isotope laboratories...
January 5, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29315370/optimal-healthcare-delivery-to-care-homes-in-the-uk-a-realist-evaluation-of-what-supports-effective-working-to-improve-healthcare-outcomes
#19
Adam L Gordon, Claire Goodman, Sue L Davies, Tom Dening, Heather Gage, Julienne Meyer, Justine Schneider, Brian Bell, Jake Jordan, Finbarr C Martin, Steve Iliffe, Clive Bowman, John R F Gladman, Christina Victor, Andrea Mayrhofer, Melanie Handley, Maria Zubair
Introduction: care home residents have high healthcare needs not fully met by prevailing healthcare models. This study explored how healthcare configuration influences resource use. Methods: a realist evaluation using qualitative and quantitative data from case studies of three UK health and social care economies selected for differing patterns of healthcare delivery to care homes. Four homes per area (12 in total) were recruited. A total of 239 residents were followed for 12 months to record resource-use...
January 5, 2018: Age and Ageing
https://www.readbyqxmd.com/read/29313860/do-environmental-dynamics-matter-in-fate-models-exploring-scenario-dynamics-for-a-terrestrial-and-an-aquatic-system
#20
Melissa Morselli, Elisa Terzaghi, Antonio Di Guardo
Nowadays, there is growing interest in inserting more ecological realism into risk assessment of chemicals. On the exposure evaluation side, this can be done by studying the complexity of exposure in the ecosystem, niche partitioning, e.g. variation of the exposure scenario. Current regulatory predictive approaches, to ensure simplicity and predictive ability, generally keep the scenario as static as possible. This could lead to under or overprediction of chemical exposure depending on the chemical and scenario simulated...
January 9, 2018: Environmental Science. Processes & Impacts
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