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https://www.readbyqxmd.com/read/27925228/a-mock-circulatory-system-incorporating-a-compliant-3d-printed-anatomical-model-to-investigate-pulmonary-hemodynamics
#1
Paul G M Knoops, Giovanni Biglino, Alun D Hughes, Kim H Parker, Linzhang Xu, Silvia Schievano, Ryo Torii
A realistic mock circulatory system (MCS) could be a valuable in vitro testbed to study human circulatory hemodynamics. The objective of this study was to design a MCS replicating the pulmonary arterial circulation, incorporating an anatomically representative arterial model suitable for testing clinically relevant scenarios. A second objective of the study was to ensure the system's compatibility with magnetic resonance imaging (MRI) for additional measurements. A latex pulmonary arterial model with two generations of bifurcations was manufactured starting from a 3D-printed mold reconstructed from patient data...
December 7, 2016: Artificial Organs
https://www.readbyqxmd.com/read/27925165/pugs-a-novel-scale-to-assess-perceptions-of-uncertainties-in-genome-sequencing
#2
Barbara B Biesecker, Samuel W Woolford, William Mp Klein, Kyle B Brothers, Kendall L Umstead, Katie L Lewis, Leslie G Biesecker, Paul Kj Han
Expectations of results from genome sequencing by end users are influenced by perceptions of uncertainty. This study aimed to assess uncertainties about sequencing by developing, evaluating, and implementing a novel scale. The Perceptions of Uncertainties in Genome Sequencing (PUGS) scale comprised ten items to assess uncertainties within three domains: clinical, affective, and evaluative. Participants (n=535) from the ClinSeq® NIH sequencing study completed a baseline survey that included the PUGS; responses (mean = 3...
December 7, 2016: Clinical Genetics
https://www.readbyqxmd.com/read/27919488/clinical-assessment-of-gait-in-individuals-with-multiple-sclerosis-using-wearable-inertial-sensors-comparison-with-patient-based-measure
#3
Massimiliano Pau, Silvia Caggiari, Alessandro Mura, Federica Corona, Bruno Leban, Giancarlo Coghe, Lorena Lorefice, Maria Giovanna Marrosu, Eleonora Cocco
BACKGROUND: This study aims to verify the feasibility of use of wearable accelerometers in an ambulatory environment to assess spatiotemporal parameters of gait in people with Multiple Sclerosis (pwMS), as well as the correlation of objective data with patient-reported outcomes. METHODS: One hundred and five pwMS (Expanded Disability Status Scale, EDSS in the range 0-6.5) classified in three sub-groups (EDSS 0-1.5, EDSS 2-4, EDSS 4.5-6.5) and 47 healthy controls (HC) participated in the study...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27915965/systematic-review-on-role-of-mammalian-target-of-rapamycin-inhibitors-as-an-alternative-to-calcineurin-inhibitors-in-renal-transplant-challenges-and-window-to-excel
#4
Jayant Kumar, Julie M Bridson, Ajay Sharma, Ahmed Halawa
OBJECTIVES: This review focuses on the current limited evidence of graft function and graft survival in various immunosuppressive regimens involving mammalian target of rapamycin inhibitors with or without calcineurin inhibitors. MATERIALS AND METHODS: We evaluated the current literature for describing the role of mammalian target of rapamycin inhibitors as an alternative to calcineurin inhibitors by searching the PubMed, EMBASE, Cochrane, Crossref, and Scopus databases using medical subject heading terms...
December 2, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27915148/antioxidant-response-of-the-hard-shelled-mussel-mytilus-coruscus-exposed-to-reduced-ph-and-oxygen-concentration
#5
Yanming Sui, Menghong Hu, Yueyong Shang, Fangli Wu, Xizhi Huang, Sam Dupont, Daniela Storch, Hans-Otto Pörtner, Jiale Li, Weiqun Lu, Youji Wang
Ocean acidification (OA) and hypoxic events are increasing worldwide problems, their interactive effects have not been well clarified, although their co-occurrence is prevalent. The East China Sea (the Yangtze River estuary area) suffers from not only coastal hypoxia but also pH fluctuation, representing an ideal study site to explore the combined effect of OA and hypoxia on marine bivalves. We experimentally evaluated the antioxidant response of the mussel Mytilus coruscus exposed to three pH levels (8.1, 7...
December 1, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27915026/effects-of-model-definitions-and-parameter-values-in-finite-element-modeling-of-human-middle-ear-mechanics
#6
Daniel De Greef, Felipe Pires, Joris J J Dirckx
BACKGROUND: Despite continuing advances in finite element software, the realistic simulation of middle ear response under acoustic stimulation continues to be challenging. One reason for this is the wide range of possible choices that can be made during the definition of a model. Therefore, an explorative study of the relative influences of some of these choices is potentially very helpful. METHOD: Three finite element models of the human middle ear were constructed, based on high-resolution micro-computed tomography scans from three different human temporal bones...
November 30, 2016: Hearing Research
https://www.readbyqxmd.com/read/27914413/differences-in-acoustic-impedance-of-fresh-and-embedded-human-trabecular-bone-samples-scanning-acoustic-microscopy-and-numerical-evaluation
#7
Xiaowei Ojanen, Juha Töyräs, Satu I Inkinen, Markus K H Malo, Hanna Isaksson, Jukka S Jurvelin
Trabecular bone samples are traditionally embedded and polished for scanning acoustic microscopy (SAM). The effect of sample processing, including dehydration, on the acoustic impedance of bone is unknown. In this study, acoustic impedance of human trabecular bone samples (n = 8) was experimentally assessed before (fresh) and after embedding using SAM and two-dimensional (2-D) finite-difference time domain simulations. Fresh samples were polished with sandpapers of different grit (P1000, P2500, and P4000)...
September 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27913617/evaluating-sequence-based-genomic-prediction-with-an-efficient-new-simulator
#8
Miguel Pérez-Enciso, Natalia Forneris, Gustavo de Los Campos, Andrés Legarra
The vast amount of sequence data to analyze complex traits is posing new challenges in terms of analysis and interpretation of the results. Although simulation is a fundamental tool to investigate the reliability of genomic analyses and to optimize experimental design, existing software cannot simulate complete genomes realistically. To remedy this, we have developed a new strategy (Sequence Based Virtual Breeding, SBVB) that consists of using real sequence data and simulating new offspring genomes and phenotypes in a very efficient and flexible manner...
December 2, 2016: Genetics
https://www.readbyqxmd.com/read/27911528/berry-curvature-in-magnon-phonon-hybrid-systems
#9
Ryuji Takahashi, Naoto Nagaosa
We study theoretically the Berry curvature of the magnon induced by the hybridization with the acoustic phonons via the spin-orbit and dipolar interactions. We first discuss the magnon-phonon hybridization via the dipolar interaction, and show that the dispersions have gapless points in momentum space, some of which form a loop. Next, when both spin-orbit and dipolar interactions are considered, we show anisotropic texture of the Berry curvature and its divergence with and without gap closing. Realistic evaluation of the consequent anomalous velocity is given for yttrium iron garnet...
November 18, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27911525/nonlinear-breit-wheeler-pair-production-in-a-tightly-focused-laser-beam
#10
A Di Piazza
The only available analytical framework for investigating QED processes in a strong laser field systematically relies on approximating the latter as a plane wave. However, realistic high-intensity laser beams feature much more complex space-time structures than plane waves. Here, we show the feasibility of an analytical framework for investigating strong-field QED processes in laser beams of arbitrary space-time structure by determining the energy spectrum of positrons produced via nonlinear Breit-Wheeler pair production as a function of the background field in the realistic assumption that the energy of the incoming photon is the largest dynamical energy in the problem...
November 18, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27909017/early-environmental-field-research-career-exploration-an-analysis-of-impacts-on-precollege-apprentices
#11
Susan K Flowers, Katherine M Beyer, Maria Pérez, Donna B Jeffe
Research apprenticeships offer opportunities for deep understanding of scientific practice, transparency about research careers, and possible transformational effects on precollege youth. We examined two consecutive field-based environmental biology apprenticeship programs designed to deliver realistic career exploration and connections to research scientists. The Shaw Institute for Field Training (SIFT) program combines introductory field-skills training with research assistance opportunities, and the subsequent Tyson Environmental Research Fellowships (TERF) program provides immersive internships on university field station-based research teams...
2016: CBE Life Sciences Education
https://www.readbyqxmd.com/read/27908182/prostate-deformation-from-inflatable-rectal-probe-cover-and-dosimetric-effects-in-prostate-seed-implant-brachytherapy
#12
Jun Lian, Yeqin Shao, Larry D Potter, Ronald C Chen, Jordan A Holmes, Eleanor A Pryser, Jie Shen, Dinggang Shen, Andrew Z Wang
PURPOSE: Prostate brachytherapy is an important treatment technique for patients with localized prostate cancer. An inflatable rectal ultrasound probe cover is frequently utilized during the procedure to adjust for unfavorable prostate position relative to the implant grid. However, the inflated cover causes prostate deformation, which is not accounted for during dosimetric planning. Most of the therapeutic dose is delivered after the procedure when the prostate and surrounding organs-at-risk are less deformed...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27908166/improved-targeting-accuracy-of-lung-tumor-biopsies-with-scanning-beam-digital-x-ray-tomosynthesis-image-guidance
#13
Geoff Nelson, Meng Wu, Cameron Hinkel, Ganesh Krishna, Tobias Funk, Jarrett Rosenberg, Rebecca Fahrig
PURPOSE: Electromagnetic navigation bronchoscopy (ENB) provides improved targeting accuracy during transbronchial biopsies of suspicious nodules. The greatest weakness of ENB-based guidance is the registration divergence that exists between the planning CT, acquired days or weeks before the intervention, and the patient on the table on the day of the intervention. Augmenting ENB guidance with real-time tomosynthesis imaging during the intervention could mitigate the divergence and further improve the yield of ENB-guided transbronchial biopsies...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27908156/development-of-a-four-axis-moving-phantom-for-patient-specific-qa-of-surrogate-signal-based-tracking-imrt
#14
Nobutaka Mukumoto, Mitsuhiro Nakamura, Masahiro Yamada, Kunio Takahashi, Mami Akimoto, Yuki Miyabe, Kenji Yokota, Shuji Kaneko, Akira Nakamura, Satoshi Itasaka, Yukinori Matsuo, Takashi Mizowaki, Masaki Kokubo, Masahiro Hiraoka
PURPOSE: The purposes of this study were two-fold: first, to develop a four-axis moving phantom for patient-specific quality assurance (QA) in surrogate signal-based dynamic tumor-tracking intensity-modulated radiotherapy (DTT-IMRT), and second, to evaluate the accuracy of the moving phantom and perform patient-specific dosimetric QA of the surrogate signal-based DTT-IMRT. METHODS: The four-axis moving phantom comprised three orthogonal linear actuators for target motion and a fourth one for surrogate motion...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27908130/exploring-connections-between-statistical-mechanics-and-green-s-functions-for-realistic-systems-temperature-dependent-electronic-entropy-and-internal-energy-from-a-self-consistent-second-order-green-s-function
#15
Alicia Rae Welden, Alexander A Rusakov, Dominika Zgid
Including finite-temperature effects from the electronic degrees of freedom in electronic structure calculations of semiconductors and metals is desired; however, in practice it remains exceedingly difficult when using zero-temperature methods, since these methods require an explicit evaluation of multiple excited states in order to account for any finite-temperature effects. Using a Matsubara Green's function formalism remains a viable alternative, since in this formalism it is easier to include thermal effects and to connect the dynamic quantities such as the self-energy with static thermodynamic quantities such as the Helmholtz energy, entropy, and internal energy...
November 28, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27907254/re-evaluation-of-individual-diameter-height-allometric-models-to-improve-biomass-estimation-of-tropical-trees
#16
Alicia Ledo, Thomas Cornulier, Janine B Illian, Yoshiko Iida, Abdul Rahman Kassim, David F R P Burslem
Accurate estimation of tree biomass is necessary to provide realistic values of the carbon stored in the terrestrial biosphere. A recognized source of errors in tree aboveground biomass (AGB) estimation is introduced when individual tree height values (H) are not directly measured but estimated from diameter at breast height (DBH) using allometric equations. In this paper, we evaluate the performance of 12 alternative DBH : H equations and compare their effects on AGB estimation for three tropical forests that occur in contrasting climatic and altitudinal zones...
December 2016: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/27907024/utility-evaluation-based-on-one-to-n-mapping-in-the-prisoner-s-dilemma-game-for-interdependent-networks
#17
Juan Wang, Wenwen Lu, Lina Liu, Li Li, Chengyi Xia
In the field of evolutionary game theory, network reciprocity has become an important means to promote the level of promotion within the population system. Recently, the interdependency provides a novel perspective to understand the widespread cooperation behavior in many real-world systems. In previous works, interdependency is often built from the direct or indirect connections between two networks through the one-to-one mapping mode. However, under many realistic scenarios, players may need much more information from many neighboring agents so as to make a more rational decision...
2016: PloS One
https://www.readbyqxmd.com/read/27905399/cellular-reactions-to-long-term-volatile-organic-compound-voc-exposures
#18
Johanna M Gostner, Johannes Zeisler, Mohammad Tauqeer Alam, Peter Gruber, Dietmar Fuchs, Kathrin Becker, Kerstin Neubert, Markus Kleinhappl, Stefan Martini, Florian Überall
Investigations of cellular processes initiated by volatile organic compounds (VOCs) are limited when modelling realistic long-term exposure scenarios at low concentrations. Exposure to indoor VOCs is associated with a range of adverse effects, but data on molecular changes at regulatory threshold limits are lacking. Activity analysis of VOC in vitro can be a valuable complement to inhalation toxicological evaluations. We developed an exposure platform that generates a stable VOC atmosphere and allows the exposure of cells for longer periods...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27896036/detecting-sedimentation-impacts-to-coral-reefs-resulting-from-dredging-the-port-of-miami-florida-usa
#19
Margaret W Miller, Jocelyn Karazsia, Carolyn E Groves, Sean Griffin, Tom Moore, Pace Wilber, Kurtis Gregg
The federal channel at Port of Miami, Florida, USA, was dredged between late 2013 and early 2015 to widen and deepen the channel. Due to the limited spatial extent of impact-assessment monitoring associated with the project, the extent of the dredging impacts on surrounding coral reefs has not been well quantified. Previously published remote sensing analyses, as well as agency and anecdotal reports suggest the most severe and largest area of sedimentation occurred on a coral reef feature referred to as the Inner Reef, particularly in the sector north of the channel...
2016: PeerJ
https://www.readbyqxmd.com/read/27894683/biomonitoring-of-humans-exposed-to-arsenic-chromium-nickel-vanadium-and-complex-mixtures-of-metals-by-using-the-micronucleus-test-in-lymphocytes
#20
REVIEW
Balasubramanyam Annangi, Stefano Bonassi, Ricard Marcos, Alba Hernández
Various metals have demonstrated genotoxic and carcinogenic potential via different mechanisms. Until now, biomonitoring and epidemiological studies have been carried out to assess the genotoxic risk to exposed human populations. In this sense, the use of the micronucleus assay in peripheral blood lymphocytes has proven to be a useful tool to determine increased levels of DNA damage, as a surrogate biomarker of cancer risk. Here we review those biomonitoring studies focused on people exposed to arsenic, chromium, nickel, vanadium and complex mixtures of metals...
October 2016: Mutation Research
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