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https://www.readbyqxmd.com/read/29350701/genetic-testing-how-genetics-and-genomics-can-affect-healthcare-disparities%C3%A2
#1
Deborah Allen
Advances in oncology care have transformed treatment approaches as genetics and genomics analyses promote implementation of personalized medicine. Genetics and genomics research in TP53 have demonstrated that some mutations are prevalent in minority populations. This has implications on personalized treatment approaches, particularly in early disease stages. The purpose of this article is to describe oncology nurses' role in applying these findings in practice to reduce disparities observed in cancer and survivorship care...
February 1, 2018: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/29348262/dawn-of-a-new-era-for-stroke-treatment-implications-of-the-dawn-study-for-acute-stroke-care-and-stroke-systems-of-care
#2
Mark J Alberts, Martin D Ollenschleger, Amre Nouh
Until recently, the selection of patients with large artery occlusion and ischemic stroke for reperfusion therapy was based on time criteria (typically within 6 hours) and basic imaging protocols (head CT, CT angiogram, ASPECTS score). The recently published DAWN (DWI or CTP Assessment with Clinical Mismatch in the Triage of Wake-Up and Late Presenting Strokes Undergoing Neurointervention with Trevo) study has changed this paradigm by using a tissue-based selection criteria and a greatly expanded treatment time window (up to 24 hours)...
January 18, 2018: Circulation
https://www.readbyqxmd.com/read/29346583/datamed-an-open-source-discovery-index-for-finding-biomedical-datasets
#3
Xiaoling Chen, Anupama E Gururaj, Burak Ozyurt, Ruiling Liu, Ergin Soysal, Trevor Cohen, Firat Tiryaki, Yueling Li, Nansu Zong, Min Jiang, Deevakar Rogith, Mandana Salimi, Hyeon-Eui Kim, Philippe Rocca-Serra, Alejandra Gonzalez-Beltran, Claudiu Farcas, Todd Johnson, Ron Margolis, George Alter, Susanna-Assunta Sansone, Ian M Fore, Lucila Ohno-Machado, Jeffrey S Grethe, Hua Xu
Objective: Finding relevant datasets is important for promoting data reuse in the biomedical domain, but it is challenging given the volume and complexity of biomedical data. Here we describe the development of an open source biomedical data discovery system called DataMed, with the goal of promoting the building of additional data indexes in the biomedical domain. Materials and Methods: DataMed, which can efficiently index and search diverse types of biomedical datasets across repositories, is developed through the National Institutes of Health-funded biomedical and healthCAre Data Discovery Index Ecosystem (bioCADDIE) consortium...
January 13, 2018: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29343253/an-integrated-primary-care-approach-for-frail-community-dwelling-older-persons-a-step-forward-in-improving-the-quality-of-care
#4
Lotte Vestjens, Jane M Cramm, Anna P Nieboer
BACKGROUND: High-quality care delivery for frail older persons, many of whom have multiple complex needs, is among the greatest challenges faced by healthcare systems today. The Chronic Care Model (CCM) may guide quality improvement efforts for primary care delivery to frail older populations. Objectives of this study were to assess the implementation of interventions in CCM dimensions, and to investigate the quality of primary care as perceived by healthcare professionals, in practices following the Finding and Follow-up of Frail older persons (FFF) integrated care approach and those providing usual care...
January 17, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29338459/an-interprofessional-collaborative-practice-approach-to-transform-heart-failure-care-an-overview
#5
Brenda K Zierler, Erin Abu-Rish Blakeney, Kevin D O'Brien, Ipcp Heart Failure Teams
Interprofessional collaborative practice (IPCP) approaches to health care are increasingly recognized as necessary to achieve the Triple Aim-improved health of the population, improved patient care experience, and improved affordability of care. This paper introduces and provides an overview of an interprofessional intervention to improve a healthcare team, healthcare system, and patient outcomes for hospitalized patients with heart failure. In this paper, we describe the overall project resulting from a workforce training grant and the proposed series of future papers resulting from the interprofessional intervention...
January 17, 2018: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/29334348/assessing-the-readiness-of-precision-medicine-interoperabilty-an-exploratory-study-of-the-national-institutes-of-health-genetic-testing-registry
#6
Jay G Ronquillo, Chunhua Weng, William T Lester
BACKGROUND:   Precision medicine involves three major innovations currently taking place in healthcare:  electronic health records, genomics, and big data.  A major challenge for healthcare providers, however, is understanding the readiness for practical application of initiatives like precision medicine. OBJECTIVE:   To better understand the current state and challenges of precision medicine interoperability using a national genetic testing registry as a starting point, placed in the context of established interoperability formats...
November 17, 2017: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/29322613/forward-view-advancing-health-library-and-knowledge-services-in-england
#7
Sue Lacey Bryant, Helen Bingham, Ruth Carlyle, Alison Day, Linda Ferguson, David Stewart
This article is the fourth in a series on New Directions. The National Health Service is under pressure, challenged to meet the needs of an ageing population, whilst striving to improve standards and ensure decision making is underpinned by evidence. Health Education England is steering a new course for NHS library and knowledge services in England to ensure access to knowledge and evidence for all decision makers. Knowledge for Healthcare calls for service transformation, role redesign, greater coordination and collaboration...
January 10, 2018: Health Information and Libraries Journal
https://www.readbyqxmd.com/read/29316861/cultures-of-caring-healthcare-scandals-inquiries-and-the-remaking-of-accountabilities
#8
Dawn Goodwin
In the UK, a series of high-profile healthcare 'scandals' and subsequent inquiries repeatedly point to the pivotal role culture plays in producing and sustaining healthcare failures. Inquiries are a sociotechnology of accountability that signal a shift in how personal accountabilities of healthcare professionals are being configured. In focusing on problematic organizational cultures, these inquiries acknowledge, make visible, and seek to distribute a collective responsibility for healthcare failures. In this article, I examine how the output of one particular inquiry - The Report of the Morecambe Bay Investigation - seeks to make culture visible and accountable...
January 1, 2018: Social Studies of Science
https://www.readbyqxmd.com/read/29313963/reverse-translation-the-art-of-cyclical-learning
#9
EDITORIAL
Sreeneeranj Kasichayanula, Karthik Venkatakrishnan
We live in an era of precision therapeutics, value-based healthcare, patient-participatory research, and enhanced clinical trial transparency, with explosive increases in our ability to access and analyze multiscale biological and clinical data from diverse ecosystems. To discover and develop truly transformative medicines with a patient-centric sense of urgency, we will need to exploit data that lie far beyond the confines of laboratory-based experimental models and controlled clinical trials, dynamically maximizing the value of information in real-world data from clinical practice settings and even social media...
February 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29313034/the-wyss-institute-a-new-model-for-medical-technology-innovation-and-translation-across-the-academic-industrial-interface
#10
REVIEW
Mary Tolikas, Ayis Antoniou, Donald E Ingber
The Wyss Institute for Biologically Inspired Engineering at Harvard University was formed based on the recognition that breakthrough discoveries cannot change the world if they never leave the laboratory. The Institute's mission is to discover the biological principles that Nature uses to build living things, and to harness these insights to create biologically inspired engineering innovations to advance human health and create a more sustainable world. Since its launch in 2009, the Institute has developed a new model for innovation, collaboration, and technology translation within academia, breaking "silos" to enable collaborations that cross institutional and disciplinary barriers...
September 2017: Bioengineering & Translational Medicine
https://www.readbyqxmd.com/read/29311233/characterization-and-protective-efficacy-of-type-three-secretion-proteins-as-a-broadly-protective-subunit-vaccine-against-salmonella-enterica-serovars
#11
Francisco J Martinez-Becerra, Prashant Kumar, Vikalp Vishwakarma, Jae Hyun Kim, Olivia Arizmendi, C Russell Middaugh, William D Picking, Wendy L Picking
Non-typhoidal Salmonella enterica serotypes (NTS) are the leading cause of hospitalization and death due to foodborne illnesses. NTS are the costliest of the foodborne pathogens and cause ∼$4 billion annually in healthcare costs. In Africa, new invasive NTS are the leading cause of bacteremia especially in HIV-positive children and adults. Current vaccines against S. enterica are not broadly protective and most are directed at the typhoid causing serotypes, not the NTS. All S. enterica require two type III secretion systems (T3SS) for virulence...
January 8, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29310442/idea4ps-the-development-of-a-research-oriented-learning-healthcare-system
#12
Susan Moffatt-Bruce, Timothy Huerta, Alice Gaughan, Ann Scheck McAlearney
Leveraging opportunities to learn and then improve the delivery of care using experiences throughout the health care system is essential in efforts to transform health care delivery. The authors present the approach of one academic medical center in becoming a research-oriented Learning Healthcare System (ro-LHS). By reframing the role of research in improving outcomes, the organization was able to move beyond its focus on quality improvement to foster a culture in which feedback informs practice and research drives improvement...
January 1, 2018: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
https://www.readbyqxmd.com/read/29305293/beyond-screening-for-chromosomal-abnormalities-advances-in-non-invasive-diagnosis-of-single-gene-disorders-and-fetal-exome-sequencing
#13
REVIEW
Jane Hayward, Lyn S Chitty
Emerging genomic technologies, largely based around next generation sequencing (NGS), are offering new promise for safer prenatal genetic diagnosis. These innovative approaches will improve screening for fetal aneuploidy, allow definitive non-invasive prenatal diagnosis (NIPD) of single gene disorders at an early gestational stage without the need for invasive testing, and improve our ability to detect monogenic disorders as the aetiology of fetal abnormalities. This presents clinicians and scientists with novel challenges as well as opportunities...
January 2, 2018: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29303815/integrating-high-reliability-principles-to-transform-access-and-throughput-by-creating-a-centralized-operations-center
#14
Paul B Davenport, Kimberly F Carter, Jeffrey M Echternach, Christopher R Tuck
High-reliability organizations (HROs) demonstrate unique and consistent characteristics, including operational sensitivity and control, situational awareness, hyperacute use of technology and data, and actionable process transformation. System complexity and reliance on information-based processes challenge healthcare organizations to replicate HRO processes. This article describes a healthcare organization's 3-year journey to achieve key HRO features to deliver high-quality, patient-centric care via an operations center powered by the principles of high-reliability data and software to impact patient throughput and flow...
January 5, 2018: Journal of Nursing Administration
https://www.readbyqxmd.com/read/29297770/the-influence-of-telepathology-on-coordination-practices
#15
Julien Meyer, Guy Paré
BACKGROUND: Coordination between physicians and allied professionals is essential to the effective delivery of care services and is associated with positive patient outcomes. As information technology can radically transform how professionals collaborate, both researchers and healthcare accreditation bodies are devoting a growing interest to the means of achieving better coordination. INTRODUCTION: The primary aim of this study is to explain the extent to which and how coordination practices between pathologists, technologists, and surgeons are transformed when telepathology is being implemented...
January 3, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/29282844/randomized-controlled-trial-evaluating-a-novel-community-eye-care-programme-for-elderly-with-visual-impairment
#16
Anna Cs Tan, Ryan Man, Chee Wai Wong, Shu Yen Lee, Ecosse L Lamoureux, Marcus Ang
IMPORTANCE: The novel intervention was effective at improving compliance to appropriate tertiary eye-care after community eye screening. BACKGROUND: Elderly individuals from low socioeconomic background with visual impairment (VI) often do not attend tertiary care, even if significant eye diseases are detected while in the community. We evaluate a novel incentive-care scheme (ICS) to improve compliance to appropriate follow-up after community eye screening. DESIGN: Randomised controlled trial in a population-based setting...
December 28, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29281894/adeno-associated-virus-2-aav2-mediated-reintroduction-of-microrna-19b-attenuates-hepatic-fibrosis
#17
Elizabeth Brandon-Warner, Jennifer H Benbow, Jacob H Swet, Nicole A Feilen, Catherine R Culberson, Iain H McKillop, Andrew S deLemos, Mark W Russo, Laura W Schrum
Fibrotic liver injury is a significant healthcare burden in the United States that represents a major cause of morbidity and mortality for which there are no effective FDA approved treatment strategies. Fibrosis is considered a disruption of normal wound healing responses mediated by fibroblastic cells which are triggered and sustained by pro-fibrotic cytokines such as transforming growth factor-beta1 (TGFβ1). TGFβ1-mediated transdifferentiation of hepatic stellate cells (HSCs) from quiescent to activated myofibroblast is a pivotal event in the development of fibrosis...
December 27, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/29276704/path-dependence-and-universal-health-coverage-the-case-of-egypt
#18
REVIEW
Ayman Fouda, Francesco Paolucci
Universal health coverage (UHC) is the big objective in health policy which several countries are seeking to achieve. Egypt is no different and its endeavors to attain UHC have been going on since the 1960s. This article discusses the status of UHC in Egypt using theories of political science and economics by analyzing the historical transformations in the Egyptian health system and its institutional settings. This article then specifically examines the path dependence theory against the sociopolitical background of Egypt and assesses any pattern between the theory and the current UHC status in Egypt...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/29275969/mobile-applications-in-children-with-cerebral-palsy
#19
M Rodríguez Mariblanca, R Cano de la Cuerda
INTRODUCTION: Cerebral palsy (CP) is one of the most common developmental disorders. Technological development has enabled a transformation of the healthcare sector, which can offer more individualised, participatory, and preventive services. Within this context of new technology applied to the healthcare sector, mobile applications, or apps, constitute a very promising tool for the management of children with CP. OBJECTIVE: The purpose of this article is to perform a systematic review of the information published about various mobile applications either directly related to CP or with potential to be useful in the context of the disease, and to describe, analyse, and classify these applications...
December 21, 2017: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/29272989/seeking-health-under-palm-trees-ayurveda-in-kerala
#20
Srinivasan Kannan, Margret Frenz
Movement for healthcare, mostly termed 'medical tourism', has been a sector of enormous potential in South Asia over the past years attracting many international clients. Kerala, a state in southern India, advertises 'Kerala Ayurveda' as one of its particular attractions. The objective of this paper is to study and understand the public health view on movements for healthcare and/or wellness across borders with a particular focus on the quality of treatments offered and on issues of ethics that concern patients from across different countries, but also the providers of Ayurveda treatments...
December 22, 2017: Global Public Health
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