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Adam B Weiner, Shilajit D Kundu
Given the high incidence of prostate cancer and the need for shared decision-making before screening, it is imperative that primary care providers understand treatment options and treatment adverse effects. In this review article, the treatment options for the localized and metastatic prostate cancer are discussed, including the different modalities and their indications, adverse effects, oncologic outcomes, posttreatment monitoring, and potential treatment options following cancer recurrence.
March 2018: Medical Clinics of North America
M Saiyad Musthafa, A Athaullah, S Anbumani, A Jawahar Ali, Mehrajuddin War, Bilal Ahmad Paray, Mohammad K Al-Sadoon, S S Muthiah, Palani Kembeeram, R Harikrishnan
Using Zebrafish (Danio rerio) as a model organism, we evaluated the radioprotective and antioxidant effects of the Indian traditional medicine Shilajit exposed to X-Ray. The Zebrafish were divided into three experimental groups and control group, each group containing ten fish. The three experimental fish groups, group I, group II and group III were fed with 3, 5 and 7ppm shilajit encapsulated Chironomous larvae and group IV served as a control fed with non- encapsulated larvae. After 60 days of feeding trial, fish were irradiated with X-Ray at a single acute dose of 1Gy...
October 2017: Applied Radiation and Isotopes
Brian J Jordan, Richard S Matulewicz, Brian Trihn, Shilajit Kundu
PURPOSE: To evaluate the rate of venous thromboembolism (VTE) after nephrectomy with specific focus on event timing and location (before or after hospital discharge) in order to identify modifiable risk factors and establish benchmarks for preventive interventions. METHODS: Using the ACS-NSQIP database, we identified patients undergoing nephrectomy from 2006 to 2012. Patients were analyzed in two cohorts: collectively and by surgical approach [open vs. lap/robotic (MIS)]...
November 2017: World Journal of Urology
Neeraj Gupta, Puneet Jain, Kuldeep Singh, Shilajit Bhattacharya
No abstract text is available yet for this article.
January 14, 2017: Journal of Tropical Pediatrics
Mehrab Dashtdar, Mohammad Reza Dashtdar, Babak Dashtdar, Gazala Afreen Khan, Karima Kardi
OBJECTIVES: The purpose of this study was to obtain a natural antibiotic from Phenol-rich compounds; for the dressing and the treatment of chronic wounds. METHODS: The Phenol-rich compound sweet gel was prepared by blending four natural herbal extracts, Acacia catechu (L.F.), Momia (Shilajit), Castanea sativa, and Ephedra sinica stapf, with combination of a sweet gel medium, including honey, maple saps, Phoenix dactylifera L. (date), pomegranate extract and Azadirachta indica gum as a stabilizer...
September 2016: Journal of Pharmacopuncture
Mohamed Saiyad Musthafa, Abdul Rahman Jawahar Ali, Abdul Rahuman Hyder Ali, Mohamed Jamal Mohamed, Mehrajuddin War, Mohamed Saquib Naveed, Mohammad K Al-Sadoon, Bilal Ahmad Paray, Kuppusamy Umaa Rani, Jesu Arockiaraj, Chellam Balasundaram, Ramasamy Harikrishnan
The effect of diet supplemented with Shilajit, a multi-component natural mineral substance on the antioxidant activity, immune response, and disease resistance in freshwater prawn, Macrobrachium rosenbergii (de Man) against Aeromonas hydrophila is reported. The total hemocyte count (THC) and phagocytic activity significantly increased with 2 g kg(-1) supplemented diet on first week and with other enriched diets on weeks 2 and 4. The respiratory burst (RB) activity and glutathione peroxidase (GPx) activity were significantly increased with 2 g kg(-1) supplemented diet on weeks 1 and 2 whereas 2 and 4 g kg(-1) diets on week 4...
October 2016: Fish & Shellfish Immunology
Michael J Nooromid, Mila H Ju, George E Havelka, James M Kozlowski, Shilajit D Kundu, Mark K Eskandari
BACKGROUND: For patients with renal cell carcinoma with venous tumor thrombus (VTT), the importance of the extent of the VTT on survival has inconsistent published results. The aim of the study was to evaluate the prognostic value of the VTT on morbidity and mortality of our patients with renal cell carcinoma. METHODS: This was a single institution review of all patients who underwent resection of renal cell carcinoma with VTT over a 15-year period. RESULTS: Thirty-seven patients (26 men, 11 women) with a mean age of 61 years were analyzed...
October 2016: Surgery
Amitava Das, Soma Datta, Brian Rhea, Mithun Sinha, Muruganandam Veeraragavan, Gayle Gordillo, Sashwati Roy
UNLABELLED: The objective of the present study ( NCT02026414) was to observe the effects of oral supplementation of a purified and standardized Shilajit extract on skeletal muscle adaptation in adult overweight/class I obese human subjects from the U.S. POPULATION: Shilajit is a mineral pitch that oozes out of Himalayan rocks. The study design consisted of a baseline visit, followed by 8 weeks of 250 mg of oral Shilajit supplementation b.i.d...
July 2016: Journal of Medicinal Food
Priya Bansal, Sugato Banerjee
BACKGROUND: Alcohol addiction is a social problem leading to both loss of health and economic prosperity among addicted individuals. Common properties of anti-addictive compounds include anti-anxiety, anticonvulsants, anti-depressant, and nootropic actions primarily through modulation of gamma-aminobutyric acid (GABA) and serotonergic systems. OBJECTIVE: Here, we screen ashwagandha and shilajit known ethnopharmacologically as nervine tonic and adaptogenic herbs for possible anti-addictive potential...
May 2016: Pharmacognosy Magazine
Richard S Matulewicz, John Oliver Lang DeLancey, Adarsh Manjunath, Jennifer Tse, Shilajit D Kundu, Joshua J Meeks
INTRODUCTION: Despite increased adoption of robotic-assisted radical cystectomy (RARC), no national data have validated its oncologic efficacy compared to the "standard" open radical cystectomy (ORC). Positive surgical margins (PSM) and lymph node (LN) yield during radical cystectomy (RC) have an established relationship with bladder cancer outcomes. Here, we propose these 2 as quality indicators for RC and assess their differences to compare the oncologic efficacy between RARC and ORC...
October 2016: Urologic Oncology
David E Victorson, Stephanie Schuette, Benjamin D Schalet, Shilajit D Kundu, Brian T Helfand, Kristian Novakovic, Nathaniel Sufrin, Michael McGuire, Charles Brendler
PURPOSE: Using patient-reported outcomes measures, we identified the most informative set of factors associated with quality of life (QOL) in a large sample of men treated for localized prostate cancer. MATERIALS AND METHODS: We examined the relationships between QOL (FACIT) and hypothesized variables using a sample of men diagnosed with localized prostate cancer who represented different time points since treatment (<12 months: n=70; 1-3 years n=344; 3-5 years n=291; >5 years n=97)...
May 31, 2016: Journal of Urology
Poonam Elhence, Meenakshi Rao, Amit Goyal, Amit Kumar, Pushpinder S Khera, Shilajit Bhattacharya
Extraosseous giant cell tumors have been described in organs like larynx, thyroid, pancreas, heart, skin, lung, colon, kidney, and soft tissues (Wu et al., Oncol Lett 2013;6:829-832). Osteoclast-like giant cell tumor of the parotid gland has been reported only rarely with the first description of primary giant cell tumour of the parotid gland (GCTPs) given in 1984 by Eusebi et al. (Am J Clin Pathol. 1984;81:666-675). However, FNAC of osteoclast-like giant cell tumor of the parotid gland has not been well described, and only one case has been reported till date (Torabinezad et al...
June 2016: Diagnostic Cytopathology
Daniel T Oberlin, David D Casalino, Frank H Miller, Richard S Matulewicz, Kent T Perry, Robert B Nadler, Shilajit Kundu, William J Catalona, Joshua J Meeks
OBJECTIVE: To better assess the increased utilization of multiparametric magnetic resonance imaging (mpMRI) and fusion biopsy of the prostate, we compared prostate cancer detection rates among (a) men undergoing MR-ultrasound (US) fusion biopsy, (b) mpMRI cognitive-registration biopsy, and (c) conventional transrectal US-guided biopsy for the detection of prostate cancer. MATERIALS AND METHODS: We present a retrospective review of consecutive patients undergoing mpMRI of the prostate with subsequent prostate biopsy from October 2013 to September 2015...
June 2016: Urology
Janardhan Prasad Bhattarai, Dong Hyu Cho, Seong Kyu Han
Shilajit, a mineral pitch, has been used in Ayurveda and Siddha system of medicine to treat many human ailments, and is reported to contain at least 85 minerals in ionic form. This study examined the possible mechanism of Shilajit action on preoptic hypothalamic neurons using juvenile mice. The hypothalamic neurons are the key regulator of many hormonal systems. In voltage clamp mode at a holding potential of -60 mV, and under a high chloride pipette solution, Shilajit induced dose-dependent inward current...
February 29, 2016: Chinese Journal of Physiology
Sharanbasappa Durg, Veeresh P Veerapur, B S Thippeswamy, Syed Mansoor Ahamed
BACKGROUND: Śilājatu (Shilajit; SJ) is claimed in traditional Indian medical practice to be useful in the treatment of nervous disorders, epilepsy and as antistress. AIM: To investigate whether SJ possesses antiepileptic and antipsychotic activities in rodents. MATERIALS AND METHODS: Isonicotinyl hydrazine (INH), pentylenetetrazole (PTZ), apomorphine, phenytoin, diazepam, haloperidol and other chemicals of analytical grade were procured from standard companies...
October 2015: Ancient Science of Life
Mete Kececi, Meryem Akpolat, Kanat Gulle, Ercan Gencer, Ahmet Sahbaz
PURPOSE: Canc er is the second leading cause of death in children in developed countries and most of childhood malignancies can be treated with chemo-radiotherapy. Although radiation therapy is a successful treatment modality in cancer patients, it has various adverse effects. Especially the gonads are very sensitive and prone to radiation-related damage. Radiation impairs the ovaries by triggering apoptosis of follicular cells and chromosomal damage and oxidative stress. Shilajit, a traditional medicinal agent in India, Russia, and other parts of the world, contains various antioxidant agents and has ovogenic effects...
June 2016: Archives of Gynecology and Obstetrics
Richard S Matulewicz, Jeffrey Brennan, Raj S Pruthi, Shilajit D Kundu, Chris M Gonzalez, Joshua J Meeks
OBJECTIVE: To present an evidence-based review of the perioperative management of the radical cystectomy (RC) patient in the context of a care redesign initiative. METHODS: A comprehensive review of the key factors associated with perioperative management of the RC patient was completed. PubMed, Medline, and the Cochrane databases were queried via a computerized search. Specific topics were reviewed within the scope of the three major phases of perioperative management: preoperative, intraoperative, and postoperative...
December 2015: Urology
Golnaz Malekzadeh, Mohammad Hossein Dashti-Rahmatabadi, Samira Zanbagh, Atefehsadat Akhavi Mirab-bashii
BACKGROUND: Mumijo (shilajit) has been well known in traditional medicine as a remedy for a number of diseases, such as bone fractures, wounds, inflammation, and headache. It is also widely used as an analgesic agent in folk medicine, but no scientific documentation exists concerning that effect. OBJECTIVE: The current study was conducted to evaluate the ability of mumijo to reduce sensitivity to painful stimuli when compared with morphine sulfate and sodium diclofenac...
March 2015: Alternative Therapies in Health and Medicine
Valeria Cagno, Manuela Donalisio, Andrea Civra, Cecilia Cagliero, Patrizia Rubiolo, David Lembo
ETHNOPHARMACOLOGICAL RELEVANCE: Shilajit, a herbomineral substance exuded from rocks in steep mountainous regions, has been used for thousands of years by the Indian Ayurvedic and Siddha systems of traditional medicine to relieve ailments and enhance quality of life. Although a large number of therapeutic properties have been ascribed to Shilajit, its therapeutic potential is still largely unexplored by modern research and many of its claimed bioactivities lack scientific validation. The present study was undertaken to investigate the antiviral activity of Shilajit against a panel of viruses including herpes simplex type 1 and 2 (HSV-1, HSV-2), human cytomegalovirus (HCMV), human respiratory syncytial virus (RSV), human rotavirus (HRV), and vesicular stomatitis virus (VSV)...
May 26, 2015: Journal of Ethnopharmacology
Stanley Y Kim, James M Dupree, Brian V Le, Dae Y Kim, Lee C Zhao, Shilajit D Kundu
OBJECTIVE: To determine a nationwide contemporary description of surgical Fournier gangrene (FG) and necrotizing fasciitis of the genitalia (NFG) outcomes because historically reported mortality rates for FG and NFG are based on small single-institution studies from the 1980s and the 1990s. METHODS: The National Surgical Quality Improvement Program is a risk-adjusted surgical database used by nearly 400 hospitals nationwide, which tracks preoperative, intraoperative, and 30-day postoperative clinical variables...
May 2015: Urology
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