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https://www.readbyqxmd.com/read/29224196/diagnostic-accuracy-of-posterior-cervical-angle-and-cervical-length-in-the-prediction-of-successful-induction-of-labor
#1
Akram M Al-Adwy, Sherin M Sobh, Doaa S Belal, Eman F Omran, Amr Hassan, Ahmed H Saad, Mai M Afifi, Adel M Nada
OBJECTIVE: To determine the accuracy of the posterior cervical angle (PCA) compared with the cervical length and the Bishop score in predicting the outcome of induction of labor (IOL). METHODS: The present prospective observational study included IOL candidates who had their PCA and cervical length assessed by transvaginal ultrasonography and the Bishop score at the Obstetrics and Gynecology Department, Kasr El-Aini Hospital, Cairo University, Cairo, Egypt, between April 1 and July 31, 2017...
December 10, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29223505/pakistan-genetic-mutation-database-pgmd-a-centralized-pakistani-mutome-data-source
#2
Iqbal Qasim, Bilal Ahmad, Muzammil Ahmad Khan, Niamatullah Khan, Noor Muhammad, Sulman Basit, Saadullah Khan
The development and advancement of next generation sequencing have not only sped up the process of identifying rare variants, but have also enabled scientists to explore all variants in a single individual. The Pakistani population has a high ratio of first degree consanguinity, which is why it is a rich source for various kinds of genetic disorders. Due to the heterogeneous composition of Pakistani population, the likelihood of genetic heterogeneity for each disorder is high. Therefore, the compilation and organization of such vast genetic data is necessary to facilitate access for analysis and interpretation to researchers and medical geneticists...
December 6, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29222825/outcome-of-sonography-based-minimally-invasive-surgery-for-deep-infiltrating-endometriosis-of-the-ureter-and-urinary-bladder-a-retrospective-cohort-study
#3
Gernot Hudelist, Ayman Tammaa, Kristine Aas-Eng, Lisa Kirchner, Nadja Fritzer, Zoltan Nemeth, Michael Lamche
INTRODUCTION: To evaluate the accuracy of transvaginal sonography for preoperative detection of bladder endometriosis and surgical outcomes regarding fertility and pain symptoms of women with urinary tract endometriosis. MATERIAL AND METHODS: Retrospective cohort study of consecutive patients with urinary tract endometriosis undergoing laparoscopic partial cystectomy and/or ureterolysis/decompression, ureteric resection and end-to-end anastomosis or ureteroneocystostomy for ureteral stenosis and hydronephrosis...
December 8, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29221446/a-systematic-review-of-test-accuracy-studies-evaluating-molecular-micro-satellite-instability-testing-for-the-detection-of-individuals-with-lynch-syndrome
#4
Helen Coelho, Tracey Jones-Hughes, Tristan Snowsill, Simon Briscoe, Nicola Huxley, Ian M Frayling, Chris Hyde
BACKGROUND: A systematic review was conducted to assess the diagnostic test accuracy of polymerase chain reaction (PCR)-based microsatellite instability (MSI) testing for identifying Lynch syndrome in patients with colorectal cancer (CRC). Unlike previous reviews, this was based on assessing MSI testing against best practice for the reference standard, and included CRC populations that were unselected, age-limited or high-risk for Lynch syndrome. METHODS: Single- and two-gate diagnostic test accuracy studies, or similar, were identified, assessed for inclusion, data extracted and quality appraised by two reviewers according to a pre-specified protocol...
December 8, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29221294/using-m-mode-ultrasonography-to-assess-diaphragm-dysfunction-and-predict-the-success-of-mechanical-ventilation-weaning-in-elderly-patients
#5
Daozheng Huang, Huan Ma, Wenzhao Zhong, Xiaoting Wang, Yan Wu, Tiehe Qin, Shouhong Wang, Ning Tan
Background: Ultrasonography (US) is a non-invasive and commonly available bedside diagnostic tool. The aim of this study was to assess the utility of M-mode US on ventilator weaning outcomes in elderly patients. Methods: This was a single center, prospective, observational study in patients aged 80 years or older who were in the medical intensive care unit, had undergone mechanical ventilation for >48 hours, and met the criteria for a spontaneous breathing trial (SBT)...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29220828/prediction-of-radiation-esophagitis-in-non-small-cell-lung-cancer-using-clinical-factors-dosimetric-parameters-and-pretreatment-cytokine-levels
#6
Peter G Hawkins, Philip S Boonstra, Stephen T Hobson, James A Hayman, Randall K Ten Haken, Martha M Matuszak, Paul Stanton, Gregory P Kalemkerian, Theodore S Lawrence, Matthew J Schipper, Feng-Ming Spring Kong, Shruti Jolly
Radiation esophagitis (RE) is a common adverse event associated with radiotherapy for non-small cell lung cancer (NSCLC). While plasma cytokine levels have been correlated with other forms of radiation-induced toxicity, their association with RE has been less well studied. We analyzed data from 126 patients treated on 4 prospective clinical trials. Logistic regression models based on combinations of dosimetric factors [maximum dose to 2 cubic cm (D2cc) and generalized equivalent uniform dose (gEUD)], clinical variables, and pretreatment plasma levels of 30 cytokines were developed...
December 5, 2017: Translational Oncology
https://www.readbyqxmd.com/read/29220511/unbiased-estimate-of-synonymous-and-non-synonymous-substitution-rates-with-non-stationary-base-composition
#7
Laurent Guéeguen, Laurent Duret
The measurement of synonymous and non-synonymous substitution rates (dS and dN) is useful for assessing selection operating on protein sequences or for investigating mutational processes affecting genomes. In particular, the ratio dNdS is expected to be a good proxy for ω, the ratio of fixation robabilities of non-synonymous mutations relative to that of neutral mutations. Standard methods for estimating dN, dS or ω rely on the assumption that the base composition of sequences is at the equilibrium of the evolutionary process...
December 6, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29220199/risk-factors-for-gaps-in-care-during-transfer-from-pediatric-to-adult-cystic-fibrosis-programs-in-the-united-states
#8
Gregory S Sawicki, Joshua Ostrenga, Kristofer Petren, Aliza K Fink, Emma D'Agostino, Camila Strassle, Michael S Schechter, Margaret Rosenfeld
RATIONALE: With improved survival into adulthood, the number of dedicated adult cystic fibrosis (CF) care programs has expanded in the US over the past decade. Transfer from pediatric to adult CF programs represents a potential time for lapses in recommended healthcare. OBJECTIVES: To describe variability in transfer between pediatric and adult CF care programs and to identify factors associated with prolonged gaps in care. METHODS: Using the US CF Foundation Patient Registry (CFFPR), we identified individuals with CF who transferred care from a pediatric to adult CF care program during 2007-2013...
December 8, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29218908/analyzing-metabolomics-data-for-association-with-genotypes-using-two-component-gaussian-mixture-distributions
#9
Jason Westra, Nicholas Hartman, Bethany Lake, Gregory Shearer, Nathan Tintle
Standard approaches to evaluate the impact of single nucleotide polymorphisms (SNP) on quantitative phenotypes use linear models. However, these normal-based approaches may not optimally model phenotypes which are better represented by Gaussian mixture distributions (e.g., some metabolomics data). We develop a likelihood ratio test on the mixing proportions of two-component Gaussian mixture distributions and consider more restrictive models to increase power in light of a priori biological knowledge. Data were simulated to validate the improved power of the likelihood ratio test and the restricted likelihood ratio test over a linear model and a log transformed linear model...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29218798/high-risk-clinical-features-for-acute-aortic-dissection-a-case-control-study
#10
Robert Ohle, Justin Um, Omar Anjum, Helena Bleeker, Lindy Luo, George Wells, Jeffrey J Perry
BACKGROUND: Acute aortic dissection (AAD) is a rare condition with a high mortality that is often missed. The objective of our study was to assess the diagnostic accuracy of clinical and laboratory findings for AAD, in confirmed cases of AAD and a low risk control group. METHODS: Historical matched case-control study: participants were adults >18 years old presenting to two tertiary care emergency departments (ED) or one regional cardiac referral center. CASES: new ED or in-hospital diagnosis of non-traumatic AAD confirmed by computed tomography or echocardiography...
December 8, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29218120/characteristics-and-correlates-of-woman-eligible-for-targeted-screening-mammography-in-oman
#11
Mahmood Masud Al Awfi, Obaid Said Al-Hubaishi
Objectives: We sought to determine the characteristics of women eligible for a high-yield screening mammography program in Oman. Methods: We conducted a retrospective review of women who underwent breast cancer screening at the Oman Cancer Association from 22 December 2009 to 6 February 2011. Women with a Breast Imaging Reporting and Data System (BI-RADS) score of 4-5 were compared with those with a score of 1-3 based on well-known breast cancer risk factors using the case-control approach analysis...
November 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29216939/-predictive-value-of-dynamic-serum-phosphorus-levels-in-the-prognosis-of-patients-with-sepsis
#12
Qiaoyun Yang, Yi Zhou, Jianfeng Yu, Dongrong Xu, Jianhong Jiang, Wenming Liu
OBJECTIVE: To explore the predictive value of dynamic serum phosphorus levels in the evaluation of prognosis in patients with sepsis. METHODS: A retrospective study was conducted. The septic patients admitted to intensive care unit (ICU) of the Second People's Hospital of Changzhou from January 2016 to June 2017 were enrolled, who were ≥18 years old and whose length of ICU stay > 72 hours. These patients were divided into survival group and death group according to 28-day outcome...
December 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29216937/-significance-of-peripheral-perfusion-index-in-early-diagnosis-and-goal-directed-therapy-of-septic-shock-patients-a-prospective-single-blind-randomized-controlled-trial
#13
Yuanfeng Shi, Ruihong Yin, Yanli Wang, Jiguang Li, Xiaobing Chen, Yongpeng Xie, Caihong Gu, Xiuzhen Zou, Kexi Liu
OBJECTIVE: To investigate the application of peripheral perfusion index (PPI) in early diagnosis and goal-directed therapy of septic shock, and to provide reference for the early clinical diagnosis and treatment of septic shock. METHODS: A prospective single-blind randomized controlled trial (RCT) was conducted. Adult patients with sepsis admitted to emergency medical department and intensive care unit (ICU) of the First People's Hospital of Lianyungang City in Jiangsu Province from January 2013 to December 2016 were enrolled...
December 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29216241/discussion-about-different-cut-off-values-of-conventional-hamstring-to-quadriceps-ratio-used-in-hamstring-injury-prediction-among-professional-male-football-players
#14
Monika Grygorowicz, Martyna Michałowska, Tomasz Walczak, Adam Owen, Jakub Krzysztof Grabski, Andrzej Pyda, Tomasz Piontek, Tomasz Kotwicki
OBJECTIVE: To measure the sensitivity and specificity of differences cut-off values for isokinetic Hcon/Qcon ratio in order to improve the capacity to evaluate (retrospectively) the injury of hamstring muscles in professional soccer screened with knee isokinetic tests. DESIGN: Retrospective study. METHODS: Medical and biomechanical data of professional football players playing for the same team for at least one season between 2010 and 2016 were analysed...
2017: PloS One
https://www.readbyqxmd.com/read/29215368/numeracy-and-interpretation-of-prognostic-estimates-in-intracerebral-hemorrhage-among-surrogate-decision-makers-in-the-neurologic-icu
#15
Nikita Leiter, Melissa Motta, Robert M Reed, Temitope Adeyeye, Debra L Wiegand, Nirav G Shah, Avelino C Verceles, Giora Netzer
OBJECTIVE: Clinicians caring for patients with intracerebral hemorrhage must often discuss prognosis and goals of care with their patients' surrogate decision makers, and may make numeric estimates of likelihood of survival and functional independence, informed by validated prediction models. Surrogates' prognostic estimates are often discordant with physicians', suggesting that physicians' numeric statements may not be accurately interpreted. We sought to assess the relationship between numeracy and interpretation of prognostic estimates in intracerebral hemorrhage among surrogate decision makers...
December 5, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29215083/association-detection-between-ordinal-trait-and-rare-variants-based-on-adaptive-combination-of-p-values
#16
Meida Wang, Weijun Ma, Ying Zhou
Next-generation sequencing technology not only presents a new method for the detection of human genomic structural variation, but also provides a large number of genetic data of rare variants for us. Currently, how to detect association between human complex diseases and rare variants using genetical data has attracted extensive attention. In the field of medicine, many people's health and disease conditions are measured by ordinal response variables, namely, the trait value reflects the development stage or severity of a certain condition...
November 7, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/29214875/genetic-polymorphisms-of-arylamine-n-acetyltransferases-1-and-2-and-the-likelihood-of-developing-pediatric-acute-lymphoblastic-leukemia
#17
Oswaldo Hernández-González, Juan José Ortiz-Zamudio, Cristian Jazmín Rodríguez-Pinal, Ildemar Alvarado-Morales, Verónica Del Carmen Martínez-Jiménez, Raúl Alejandro Salazar-González, Lourdes Cecilia Correa-González, Rocío Gómez, Diana Patricia Portales-Pérez, Rosa Del Carmen Milán-Segovia
Acute lymphoblastic leukemia (ALL) is one of the main causes of death in children and is associated with both genetic susceptibility and environmental factors. Genes encoding the arylamine N-acetyltransferases 1 and 2 (NAT1 and NAT2) isoenzymes are highly polymorphic among populations. Single-nucleotide polymorphism analysis was performed by real-time polymerase chain reaction from the genomic DNA of 225 healthy subjects and 57 children with ALL diagnoses. Significant associations were found between the development of ALL and the presence of the haplotypes NAT1*3 (Odds ratio [OR], 2...
December 7, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29214844/barriers-to-quitting-smoking-among-young-adults-the-role-of-socioeconomic-status
#18
Samantha Carlson, Rachel Widome, Lindsey Fabian, Xianghua Luo, Jean Forster
PURPOSE: The aims of this analysis were to explore how self-reported barriers to quitting vary by socioeconomic status (SES) among young-adult smokers and to assess their relationship to quitting. DESIGN: This analysis uses 2 waves of telephone-survey data from the Minnesota Adolescent Community Cohort study. SETTING: Midwestern United States. PARTICIPANTS: Participants (n = 419) were smokers aged 17 to 24 years. MEASURES: Socioeconomic status was estimated using the highest level of education completed by the participants' parents...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29214820/weight-management-behaviors-among-mexican-american-youth-cross-sectional-variation-by-timing-of-growth-and-maturation
#19
Jennifer L Gay, Eva V Monsma, Katie Darby Hein
PURPOSE: To assess the association between growth and maturation with weight management behaviors (WMBs) among Mexican American youth. DESIGN: A cross-sectional design was used to measure timing of growth and maturation as well as WMBs. SAMPLE: Students were recruited through physical education classes in south Texas schools. The sample included 623 participants (52.3% female; 49.8% with weight ≥85th percentile) in grades 4 through 12. Students in middle school were purposely oversampled to examine questions around timing of growth and maturation...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29214633/placenta-accreta-spectrum-disorder-trends-in-the-context-of-the-universal-two-child-policy-in-china-and-the-risk-of-hysterectomy
#20
Chanjuan Zeng, Mengyuan Yang, Yiling Ding, Siqi Duan, Yang Zhou
OBJECTIVE: To identify both the trends in placenta accreta spectrum (PAS) disorders in the context of the universal two-child policy in China and risk factors for hysterectomy. METHODS: The present retrospective analysis included confirmed PAS disorders during cesarean delivery at a tertiary hospital in Changsha, Hunan, China, from January 1, 2007, to December 31, 2016. Multivariable logistic regression was used to estimate the risk of hysterectomy. RESULTS: During the 10-year study period, the overall incidence of cesarean delivery was 51...
December 7, 2017: International Journal of Gynaecology and Obstetrics
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