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https://www.readbyqxmd.com/read/29457638/a-dialectical-behavior-therapy-skills-intervention-for-women-with-suicidal-behaviors-in-rural-nepal-a-single-case-experimental-design-series
#1
Megan K Ramaiya, Caitlin McLean, Upasana Regmi, Devika Fiorillo, Clive J Robins, Brandon A Kohrt
BACKGROUND: Suicide in low- and middle-income countries (LMICs) accounts for 75% of the world's burden of suicide mortality and is the leading single cause of death among Nepali reproductive age women. To advance treatment for suicidal behaviors in LMICs, a single-case experimental design (SCED) was conducted of a culturally adapted Dialectical Behavior Therapy skills intervention for Nepali populations (DBT-N). METHOD: Ten Nepali women with histories of suicidality participated in the 10-session intervention...
February 19, 2018: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29456439/parent-training-and-skill-acquisition-and-utilization-among-spanish-and-english-speaking-latino-families
#2
Giovanni Ramos, Angela M Blizzard, Nicole E Barroso, Daniel M Bagner
In the U.S., there is a growing Latino population, in which parents primarily speak Spanish to their children. Despite the evidence that language preference is associated with level of acculturation and influences parenting practices in these families, no study has compared how Spanish-and English-speaking Latino families acquire and utilize the skills taught during parent-training programs such as Parent-Child Interaction Therapy (PCIT). Twenty-seven mother-infant Latino dyads received a home-based adaptation of the Child-Directed Interaction (CDI) phase of PCIT as part of a larger randomized control trial...
January 2018: Journal of Child and Family Studies
https://www.readbyqxmd.com/read/29456140/visual-selective-attention-in-mice
#3
Lupeng Wang, Richard J Krauzlis
Visual selective attention is a fundamental cognitive ability that allows us to process relevant visual stimuli while ignoring irrelevant distracters and has been extensively studied in human and non-human primate subjects. Mice have emerged as a powerful animal model for studying aspects of the visual system but have not yet been shown to exhibit visual selective attention. Differences in the organization of the visual systems of primates and mice raise the possibility that selective visual attention might not be present in mice, at least not in the forms that are well established in primates...
February 8, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29455722/computer-assisted-motivational-interviewing-intervention-to-facilitate-teen-pregnancy-prevention-and-fitness-behavior-changes-a-randomized-trial-for-young-men
#4
David L Bell, Samantha Garbers, Marina Catallozzi, R Stanley Hum, Meredith Nechitilo, Ian W McKeague, Emilia H Koumans, L Duane House, Susan L Rosenthal, Melanie A Gold
PURPOSE: Despite recent declines, teen unintended pregnancy and sexually transmitted infections in the United States remain at levels higher than comparable nations. Initiatives to prevent teen pregnancy have focused primarily on female adolescents; how to effectively engage young men to reduce their risk of fathering a teen pregnancy has not been well studied. We proposed to adapt an innovative computer-assisted motivational interviewing (CAMI) intervention, originally designed and tested with young women, for use with young men, aged 15-24 years, to reduce their risk of fathering a teen pregnancy...
March 2018: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29455428/potential-of-feeding-beef-cattle-with-whole-corn-crop-silage-and-rice-straw-in-malaysia
#5
Muhamad Hazim Nazli, Ridzwan Abdul Halim, Amin Mahir Abdullah, Ghazali Hussin, Anjas Asmara Samsudin
The potential of using whole corn crop silage and rice straw as an alternative feed for the beef cattle based on the intake and growth performance were evaluated. Using randomised completely block design, nine adult Mafriwal cattle were blocked intro three groups and treated with three different forage diets supplemented with 20% pelleted palm kernel cake on dry matter basis. The treatments were 100% rice straw (RS), 100% corn silage (CS) and an equal mixture of rice straw and corn silage (MIX) fed ad libitum...
February 17, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29454854/erk1-2-inhibitors-new-weapons-to-inhibit-the-ras-regulated-raf-mek1-2-erk1-2-pathway
#6
REVIEW
Andrew M Kidger, James Sipthorp, Simon J Cook
The RAS-regulated RAF-MEK1/2-ERK1/2 signalling pathway is de-regulated in a variety of cancers due to mutations in receptor tyrosine kinases (RTKs), negative regulators of RAS (such as NF1) and core pathway components themselves (RAS, BRAF, CRAF, MEK1 or MEK2). This has driven the development of a variety of pharmaceutical agents to inhibit RAF-MEK1/2-ERK1/2 signalling in cancer and both RAF and MEK inhibitors are now approved and used in the clinic. There is now much interest in targeting at the level of ERK1/2 for a variety of reasons...
February 15, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29454351/disparate-compensation-policies-for-research-related-injury-in-an-era-of-multinational-trials-a-case-study-of-brazil-russia-india-china-and-south-africa
#7
George Rugare Chingarande, Keymanthri Moodley
BACKGROUND: Compensation for research related injuries is a subject that is increasingly gaining traction in developing countries which are burgeoning destinations of multi center research. However, the existence of disparate compensation rules violates the ethical principle of fairness. The current paper presents a comparison of the policies of Brazil, Russia, India, China and South Africa (BRICS). METHODS: A systematic search of good clinical practice guidelines was conducted employing search strategies modeled in line with the recommendations of ADPTE Collaboration (2007)...
February 17, 2018: BMC Medical Ethics
https://www.readbyqxmd.com/read/29454141/a-cluster-randomized-pilot-trial-of-a-tailored-worksite-smoking-cessation-intervention-targeting-hispanic-latino-construction-workers-intervention-development-and-research-design
#8
Taghrid Asfar, Alberto J Caban-Martinez, Laura A McClure, Estefania C Ruano-Herreria, Danielle Sierra, G Gilford Clark, Daniel Samano, Noella A Dietz, Kenneth D Ward, Kristopher L Arheart, David J Lee
Construction workers have the highest smoking rate among all occupations (39%). Hispanic/Latino workers constitute a large and increasing group in the US construction industry (over 2.6 million; 23% of all workers). These minority workers have lower cessation rates compared to other groups due to their limited access to cessation services, and lack of smoking cessation interventions adapted to their culture and work/life circumstances. Formative research was conducted to create an intervention targeting Hispanic/Latino construction workers...
February 14, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29453756/acute-effects-of-unilateral-static-stretching-on-handgrip-strength-of-the-stretched-and-non-stretched-limb
#9
Jacob D Jelmini, Andrew Cornwell, Nazareth Khodiguian, Jennifer Thayer, And John Araujo
PURPOSE: To determine the effects of an acute bout of unilateral static stretching on handgrip strength of both the stretched and non-stretched limb. It was reasoned that if the non-stretched limb experienced a decrease in force output, further evidence for a neural mechanism to explain a post-stretch force reduction would be obtained as no mechanical adaptation would have occurred. METHODS: Thirty participants performed maximum voluntary unilateral handgrip contractions of both limbs before and after stretching the finger flexors of the strength-dominant side only...
February 16, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29453496/influence-of-surface-treatment-on-the-performance-of-silorane-based-composite-resin-in-class-i-restorations-a-randomized-clinical-trial
#10
Isabella Pereira Marques, Fabíola Belkiss Santos de Oliveira, João Gabriel Silva Souza, Raquel Conceição Ferreira, Claudia Silami Magalhães, Fabiana Mantovani Gomes França, Daniela Araújo Veloso Popoff
OBJECTIVES: The aim of this study was to evaluate the clinical performance of silorane-based composite restorations applied after different surface treatments. MATERIALS AND METHODS: This controlled and randomized clinical trial included 26 patients with class I restoration indications. The teeth were randomly assigned to the following treatments: control 1/G1, silorane specific self-etching adhesive (P90 self-etch primer and bond) + silorane-based composite resin (Filtek™ P90 low shrink posterior restorative); G2, 37% phosphoric acid + silorane specific self-etching adhesive + silorane-based composite resin; G3, blasting with aluminum oxide + silorane specific self-etching adhesive + silorane-based composite resin; and control 2/G4, self-etching adhesive (Adper™ SE Plus self-etch adhesive) + dimethacrylate-based composite resin (Filtek™ P60 posterior restorative)...
February 16, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29453328/management-of-atrial-fibrillation-in-patients-with-rheumatic-mitral-stenosis
#11
REVIEW
Bernard Iung, Antoine Leenhardt, Fabrice Extramiana
Atrial fibrillation (AF) is frequent in patients with rheumatic mitral stenosis (MS). Pressure overload leads to marked structural and electrical remodelling of left atrium. The frequency of persistent AF increases with age and paroxysmal, asymptomatic, AF seems even more frequent. The occurrence of AF worsens the haemodynamic tolerance of MS and markedly increases the risk of thromboembolic events. AF has a negative impact on the natural history of MS and on its outcome after commissurotomy. The respective indications of rhythm and rate control should be adapted to patient characteristics, particularly the consequences of MS, and take into account the high risk of recurrence of AF...
February 16, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29453191/a-text-message-intervention-with-adaptive-goal-support-to-reduce-alcohol-consumption-among-non-treatment-seeking-young-adults-non-randomized-clinical-trial-with-voluntary-length-of-enrollment
#12
Brian Suffoletto, Tammy Chung, Frederick Muench, Peter Monti, Duncan B Clark
BACKGROUND: Stand-alone text message-based interventions can reduce binge drinking episodes (≥4 drinks for women and ≥5 drinks for men) among nontreatment-seeking young adults, but may not be optimized. Adaptive text message support could enhance effectiveness by assisting context-specific goal setting and striving, but it remains unknown how to best integrate it into text message interventions. OBJECTIVE: The objective of this study was to evaluate young adults' engagement with a text message intervention, Texting to Reduce Alcohol Consumption 2 (TRAC2), which focuses on reducing weekend alcohol consumption...
February 16, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29453101/can-higher-training-practice-dosage-with-treadmill-slip-perturbation-necessarily-reduce-risk-of-falls-following-overground-slip
#13
Anna Lee, Tanvi Bhatt, Xuan Liu, Yiru Wang, Yi-Chung Pai
BACKGROUND: Perturbation training is an emerging paradigm to reduce idiopathic falls (without clinical signs or symptoms) in older adults. While a higher threat dosage (intensity) in motor learning often directly relates to greater adaptation, retention, and generalization, little is known whether increasing the practice dosage (repetition) of slip-perturbation training would necessarily improve its outcomes. RESEARCH QUESTION: Can higher practice dosage of treadmill slip-perturbation training lead to greater generalization to an overground slip immediately after the training? METHODS: Forty-five community-dwelling older adults (73...
February 13, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29452985/effectiveness-of-two-home-ergonomic-programs-in-reducing-pain-and-enhancing-quality-of-life-in-informal-caregivers-of-post-stroke-patients-a-pilot-randomized-controlled-clinical-trial
#14
Karen Lucia de Araújo Freitas Moreira, Gracia María Ábalos-Medina, Carmen Villaverde-Gutiérrez, Neide María Gomes de Lucena, Anderson Belmont Correia de Oliveira, José Manuel Pérez-Mármol
BACKGROUND: Informal caregivers of post-stroke patients usually undergo high levels of pain and stress and have a reduced quality of life. OBJECTIVE: To evaluate the effectiveness of two home ergonomic interventions aimed at reducing pain intensity and perceived stress and enhancing the quality of life in informal caregivers of chronic post-stroke patients. METHODS: A randomized single-blind controlled clinical trial was conducted, with a sample of 33 informal caregivers of patients with stroke...
February 13, 2018: Disability and Health Journal
https://www.readbyqxmd.com/read/29452290/lean-body-weight-is-the-best-scale-for-venous-thromboprophylaxis-algorithm-in-severely-obese-patients-undergoing-bariatric-surgery
#15
Bénédicte Gaborit, Pierre-Antoine Moulin, Thierry Bege, Sandrine Boullu, Clara Vincentelli, Olivier Emungania, Pierre-Emmanuel Morange, Stéphane Berdah, Joe-Elie Salem, Anne Dutour, Corinne Frere
Severely obese patients undergoing bariatric surgery (BS) are at increased risk for venous thromboembolism (VTE). How standard low molecular weight heparin (LMWH) regimen should be adapted to provide both sufficient efficacy and safety in this setting is unclear. We aimed to compare the influence of four body size descriptors (BSD) on peak anti-Xa levels in BS obese patients receiving LMWH fixed doses to identify which one had the greatest impact. One hundred and thirteen BS obese patients [median body mass index (BMI), 43...
February 13, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29451922/identifying-classifier-input-signals-to-predict-a-cross-slope-during-transtibial-amputee-walking
#16
Courtney E Shell, Glenn K Klute, Richard R Neptune
Advanced prosthetic foot designs often incorporate mechanisms that adapt to terrain changes in real-time to improve mobility. Early identification of terrain (e.g., cross-slopes) is critical to appropriate adaptation. This study suggests that a simple classifier based on linear discriminant analysis can accurately predict a cross-slope encountered (0°, -15°, 15°) using measurements from the residual limb, primarily from the prosthesis itself. The classifier was trained and tested offline using motion capture and in-pylon sensor data collected during walking trials in mid-swing and early stance...
2018: PloS One
https://www.readbyqxmd.com/read/29451470/use-of-integrated-clinical-trial-protocols-a-survey-in-early-medicines-development
#17
Katharina Erb-Zohar, Hildegard Sourgens, Kerstin Breithaupt-Groegler
PURPOSE: To collect information on the use of integrated protocols in early clinical medicines development. MATERIALS AND METHODS: The questionnaire was mailed in fall 2014 to members of human pharmacology societies in Europe for anonymous responses via the online tool SurveyMonkey®. RESULTS: 97 respondents reported on 164 integrated protocols overall. In general, integrated protocols comprised 2 or 3 trial elements. One third of integrated protocols involved patients...
February 16, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29450789/control-by-association-transfer-of-implicitly-primed-attentional-states-across-linked-stimuli
#18
Christina Bejjani, Ziwei Zhang, Tobias Egner
Although cognitive control has traditionally been viewed in opposition to associative learning, recent studies show that people can learn to link particular stimuli with specific cognitive control states (e.g., high attentional selectivity). Here, we tested whether such learned stimulus-control associations can transfer across paired-associates. In the Stimulus-Stimulus (S-S) Association phase, specific face or house images repeatedly preceded the presentation of particular scene stimuli, creating paired face/house-scene associates in memory...
February 15, 2018: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/29450524/effect-of-a-quality-improvement-intervention-on-clinical-outcomes-in-patients-in-india-with-acute-myocardial-infarction-the-acs-quik-randomized-clinical-trial
#19
Mark D Huffman, Padinhare P Mohanan, Raji Devarajan, Abigail S Baldridge, Dimple Kondal, Lihui Zhao, Mumtaj Ali, Mangalath N Krishnan, Syam Natesan, Rajesh Gopinath, Sunitha Viswanathan, Joseph Stigi, Johny Joseph, Somanathan Chozhakkat, Donald M Lloyd-Jones, Dorairaj Prabhakaran
Importance: Wide heterogeneity exists in acute myocardial infarction treatment and outcomes in India. Objective: To evaluate the effect of a locally adapted quality improvement tool kit on clinical outcomes and process measures in Kerala, a southern Indian state. Design, Setting, and Participants: Cluster randomized, stepped-wedge clinical trial conducted between November 10, 2014, and November 9, 2016, in 63 hospitals in Kerala, India, with a last date of follow-up of December 31, 2016...
February 13, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29449861/application-of-electrical-capacitance-method-for-prediction-of-plant-root-mass-and-activity-in-field-grown-crops
#20
Imre Cseresnyés, Katalin Szitár, Kálmán Rajkai, Anna Füzy, Péter Mikó, Ramóna Kovács, Tünde Takács
The root electrical capacitance (C R ) method is suitable for assessing root growth and activity, but soil water content (SWC) strongly influences the measurement results. This study aimed to adapt the method for field monitoring by evaluating the effect of SWC on root capacitance to ensure the comparability of C R detected at different SWC. First a pot experiment was conducted with maize and soybean to establish C R -SWC functions for the field soil. Ontogenetic changes in root activity were monitored under field conditions by simultaneously measuring C R and SWC around the roots...
2018: Frontiers in Plant Science
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