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Adaptive design

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https://www.readbyqxmd.com/read/29782445/comparing-two-hearing-aid-fitting-algorithms-for-bimodal-cochlear-implant-users
#1
Jantien L Vroegop, Nienke C Homans, Marc P van der Schroeff, André Goedegebure
OBJECTIVES: To investigate the possible advantage of the use of a dedicated bimodal hearing aid fitting formula, the Adaptive Phonak Digital Bimodal (APDB), compared with a frequently used standard hearing aid fitting formula, the NAL-NL2. We evaluated the effects of bimodal hearing aid fitting on provided hearing aid gain and on bimodal auditory functioning in a group of experienced bimodal cochlear implant (CI) users. A second aim of our study was to determine the effect of broadband loudness balancing on the prescribed gain of those two fitting formulas...
May 16, 2018: Ear and Hearing
https://www.readbyqxmd.com/read/29782061/improving-self-management-for-persons-with-parkinson-s-disease-through-education-focusing-on-management-of-daily-life-patients-and-relatives-experience-of-the-swedish-national-parkinson-school
#2
Carina Hellqvist, Nil Dizdar, Peter Hagell, Carina Berterö, Märta Sund Levander
AIMS AND OBJECTIVE: The two folded aim of this study was firstly to identify and describe experiences valuable for managing daily life after participation in the NPS self-management intervention. The second part was to explore the applicability of the Self- and family management framework by Grey and colleagues for persons with Parkinson's Disease and their relatives. BACKGROUND: The impact of PD is evident on the lives of both patients and relatives. The National Parkinson School (NPS) is a Swedish self-management program designed for patients and relatives, aiming at teaching strategies helpful for the ability of self-management, in order to promote life satisfaction...
May 21, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29781818/lower-extremity-megaprostheses-in-orthopaedic-oncology
#3
Santiago A Lozano Calderón, Joseph Kuechle, Kevin A Raskin, Francis J Hornicek
The megaprosthesis is designed to reproduce the form and function of a removed or lost large segment of bone and accompanying soft tissues. Slow but substantial improvements in the design and surgical implementation of these devices have advanced the capacity to restore patients' functional abilities. The essential challenges include identifying the ideal materials, bonding these materials to bone and soft tissues, reproducing functional anatomy, and adapting to the growing skeleton. Failure of these devices can result from soft-tissue insufficiency, aseptic loosening, structural failures, infection, and tumor recurrence...
May 17, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29781743/a-treatment-comparison-study-of-a-photo-activity-schedule-and-social-stories-for-teaching-social-skills-to-children-with-autism-spectrum-disorder-brief-report
#4
Sabrina D Daneshvar, Marjorie H Charlop, Debra Berry Malmberg
PURPOSE: To compare the efficacy of two procedures, a photo activity schedule intervention and Social Stories, to teach social skills to four children diagnosed with Autism Spectrum Disorder (ASD). METHODS: An adapted alternating treatments design with an additional multiple baseline control was used, and two social skills were targeted for each of the four participants, one under each intervention condition. RESULTS: Results indicated that all four participants learned the target social behaviours with the photo activity schedule intervention, but did not learn target social behaviours with Social Stories...
May 21, 2018: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/29781646/emotional-clarity-development-and-psychosocial-outcomes-during-adolescence
#5
Liza M Haas, Brae Anne McArthur, Taylor A Burke, Thomas M Olino, Lyn Y Abramson, Lauren B Alloy
Past research on emotional clarity (EC), the ability to identify and label one's own emotions, has illustrated an association between EC deficits and poor psychosocial outcomes during the adolescent years. Although past research has connected EC to psychosocial outcomes during adolescence in cross-sectional and longitudinal designs, no studies have traced the trajectory of EC over time to determine the developmental course of the construct during adolescence. Thus, this study investigated how EC developed over five years during adolescence and what factors were associated with the developmental trajectory of emotional clarity...
May 21, 2018: Emotion
https://www.readbyqxmd.com/read/29781292/adaptation-of-the-contraceptive-behavior-scale-for-mexican-heterosexual-populations
#6
María Luisa Flores Arias, Jane Dimmitt Champion, Norma Elva Sáenz Soto, Vianet Nava Navarro, Lucia Caudillo Ortega
INTRODUCTION: The Contraceptive Behavior Scale requires adaptation for use by health professionals among Mexican heterosexual populations of reproductive age. METHODS: Cross-sectional, descriptive, correlational design assessed adaptation of the Contraceptive Behavior Scale. RESULTS: Six hundred Mexican men and women of reproductive age (18-35 years) were recruited from a second-level health care unit in a metropolitan area in Mexico. Exploratory factor analysis identified two factors with an explanatory variance of 69...
January 1, 2018: Hispanic Health Care International: the Official Journal of the National Association of Hispanic Nurses
https://www.readbyqxmd.com/read/29781253/developmental-plasticity-in-reptiles-insights-from-temperature-dependent-gene-expression-in-wall-lizard-embryos
#7
Nathalie Feiner, Alfredo Rago, Geoffrey M While, Tobias Uller
Many features of the development of reptiles are affected by temperature, but very little is known about how incubation temperature affects gene expression. Here, we provide a detailed case study of gene expression profiles in common wall lizard (Podarcis muralis) embryos developing at stressfully low (15°C) versus benign (24°C) temperature. For maximum comparability between the two temperature regimes, we selected a precise developmental stage early in embryogenesis defined by the number of somites. We used a split-clutch design and lizards from four different populations to evaluate the robustness of temperature-responsive gene expression profiles...
May 20, 2018: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
https://www.readbyqxmd.com/read/29780812/characteristics-of-mobile-phone-access-and-usage-in-rural-and-urban-guatemala-assessing-feasibility-of-text-message-reminders-to-increase-childhood-immunizations
#8
Gretchen J Domek, Ingrid L Contreras-Roldan, Edwin J Asturias, Michael Bronsert, Guillermo Antonio Bolaños Ventura, Sean T O'Leary, Allison Kempe, Sheana Bull
Background: Despite efforts to promote vaccination in low- and middle-income countries (LMICs), over 20 million infants remain under-immunized and at risk for unnecessary morbidity and mortality. Mobile health technologies, such as Short Message Service (SMS) texts, have tremendous and untapped potential for disease management. Patient reminder systems are an important mechanism for improving childhood vaccination coverage and can be easily adapted to SMS platforms. However, current research lacks an understanding of the barriers and facilitators to mHealth program design, implementation, and scale in LMICs...
2018: MHealth
https://www.readbyqxmd.com/read/29780712/advantages-of-wound-retractor-device-versus-rigid-trocar-at-camera-port-in-video-assisted-thoracic-surgery-a-single-institution-experience
#9
Federico Raveglia, Ugo Cioffi, Matilde De Simone, Alessandro Rizzi, Andrea Leporati, Carmine Tinelli, Marco Chiarelli, Alessandro Baisi
Background: rigid trocars are widely adopted in video-assisted thoracic surgery (VATS), despite some disadvantages: (I) cannula strong pressure on intercostal nerve stimulating postoperative pain; (II) limited movement of thoracoscopic devices on their fulcrum when extreme acute angles with the chest wall are needed. Wound retractor (WR) device, designed for laparoscopic surgery, it is also used in VATS, but to protect mini-thoracotomy. We compared the use of extra-small WR versus rigid trocar at camera port that is the most painful thoracostomy...
2018: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29780528/synthetic-glycan-based-tlr4-agonists-targeting-caspase-4-11-for-the-development-of-adjuvants-and-immunotherapeutics
#10
Florian Adanitsch, Jianjin Shi, Feng Shao, Rudi Beyaert, Holger Heine, Alla Zamyatina
Gram-negative bacterial lipopolysaccharide (LPS)-induced Toll-like receptor 4 (TLR4) mediated pro-inflammatory signaling plays a key role in immunoprotection against infectious challenges and boosts adaptive immunity, whereas the activation of the cytosolic LPS receptor caspase-4/11 leads to cell death by pyroptosis and is deeply implicated in the development of sepsis. Despite tremendous advances in the understanding of the LPS-TLR4 interaction, predictably regulated TLR4 activation has not yet been achieved...
April 28, 2018: Chemical Science
https://www.readbyqxmd.com/read/29779466/a-systematic-review-of-shock-attenuating-componentry-for-lower-limb-amputees
#11
Mitchell Farrar, Emma Thomas
BACKGROUND: Shock-attenuating pylons are commonly fitted to prostheses in order to compensate for the anatomical and biomechanical shock-absorbing features of the lower limb removed upon amputation. However, studies concerning their shock-attenuating capacity are highly variable and, to date, have not yet been reviewed, making them difficult to interpret and apply in clinical practice. OBJECTIVES: To synthesise and appraise the available literature examining the effectiveness of shock-attenuating pylons in attenuating shock upon limb loading compared to rigid pylons among lower limb amputees...
May 1, 2018: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/29778852/do-we-need-independent-data-monitoring-boards-and-adaptive-designs-for-diagnostic-outcome-trials
#12
EDITORIAL
Alan G Fraser, Abbas Zaidi
No abstract text is available yet for this article.
May 11, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29778791/evolutionary-transitions-in-controls-reconcile-adaptation-with-continuity-of-evolution
#13
REVIEW
Alexander V Badyaev
Evolution proceeds by accumulating functional solutions, necessarily forming an uninterrupted lineage from past solutions of ancestors to the current design of extant forms. At the population level, this process requires an organismal architecture in which the maintenance of local adaptation does not preclude the ability to innovate in the same traits and their continuous evolution. Representing complex traits as networks enables us to visualize a fundamental principle that resolves tension between adaptation and continuous evolution: phenotypic states encompassing adaptations traverse the continuous multi-layered landscape of past physical, developmental and functional associations among traits...
May 17, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29778738/risk-adapted-therapy-for-young-children-with-medulloblastoma-sjyc07-therapeutic-and-molecular-outcomes-from-a-multicentre-phase-2-trial
#14
Giles W Robinson, Vasilisa A Rudneva, Ivo Buchhalter, Catherine A Billups, Sebastian M Waszak, Kyle S Smith, Daniel C Bowers, Anne Bendel, Paul G Fisher, Sonia Partap, John R Crawford, Tim Hassall, Daniel J Indelicato, Frederick Boop, Paul Klimo, Noah D Sabin, Zoltan Patay, Thomas E Merchant, Clinton F Stewart, Brent A Orr, Jan O Korbel, David T W Jones, Tanvi Sharma, Peter Lichter, Marcel Kool, Andrey Korshunov, Stefan M Pfister, Richard J Gilbertson, Robert P Sanders, Arzu Onar-Thomas, David W Ellison, Amar Gajjar, Paul A Northcott
BACKGROUND: Young children with medulloblastoma have a poor overall survival compared with older children, due to use of radiation-sparing therapy in young children. Radiotherapy is omitted or reduced in these young patients to spare them from debilitating long-term side-effects. We aimed to estimate event-free survival and define the molecular characteristics associated with progression-free survival in young patients with medulloblastoma using a risk-stratified treatment strategy designed to defer, reduce, or delay radiation exposure...
May 16, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29778515/safety-and-immunogenicity-of-fractional-dose-intradermal-injection-of-two-quadrivalent-conjugated-meningococcal-vaccines
#15
Emile F F Jonker, Mariëtte B van Ravenhorst, Guy A M Berbers, Leo G Visser
BACKGROUND: Vaccination with conjugated meningococcal vaccines is the best way to prevent invasive meningococcal disease. Changes in serogroup epidemiology have led to the inclusion of quadrivalent vaccines in the national immunization programs of several countries, but vaccines are frequently in short supply. Intradermal administration has the potential to increase vaccine availability through dose reduction, without sacrificing efficacy. It has never before been investigated for glycoconjugate meningococcal vaccines...
May 16, 2018: Vaccine
https://www.readbyqxmd.com/read/29778483/effect-of-replacing-maize-silage-with-red-clover-silage-in-the-diet-on-milk-fatty-acid-composition-in-cows
#16
Franziska Schulz, Edwin Westreicher-Kristen, Joachim Molkentin, Karin Knappstein, Andreas Susenbeth
This study aimed to evaluate the effect of replacing maize silage plus soybean meal with red clover silage (RCS) plus wheat on the fatty acid (FA) profile in the milk fat of cows. Forty-four lactating German Holstein cows were used in a 4 × 4 Latin square design with 21-d periods composed of 13 d of adaptation to diets followed by an 8-d sampling phase. Experimental diets offered as total mixed ration consisted of a constant forage-to-concentrate ratio (75:25) with target proportions of RCS to maize silage of 15:60 (RCS15 ), 30:45 (RCS30 ), 45:30 (RCS45 ), and 60:15 (RCS60 ) on a dry matter basis...
May 16, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29777747/social-environment-as-a-factor-affecting-exploration-and-learning-in-pre-juvenile-rats
#17
Klaudia Modlinska, Rafał Stryjek, Anna Chrzanowska, Wojciech Pisula
Stress associated with social isolation in early life can lead to disturbances in the emotional regulation in adult rats. However, there are no reports on the impact of isolation from the mother while providing contact with peers. Under such conditions, young individuals have the opportunity to interact with others, are able to develop social behaviour, etc. Yet, there is no stimulation and care provided by the mother. We examined the relative impact of maternal contact and sibling contact in the rarely studied pre-juvenile (3rd and 4th week post birth) period on subsequent development...
May 16, 2018: Behavioural Processes
https://www.readbyqxmd.com/read/29777617/simulation-in-urology-to-train-non-technical-skills-in-ward-rounds
#18
K Somasundram, H Spence, A J Colquhoun, C Mcilhenny, C S Biyani, S Jain
OBJECTIVE: We have designed an exercise to train newly appointed Urology trainees in non-technical skills on ward rounds as a part of a simulation 'boot camp'. This paper reports our experience, including a qualitative analysis of participant feedback on the utility of this method of training. PATIENTS AND METHODS: The simulations took place in a high-fidelity simulated ward bay. Forty-eight doctors with formal Urology training ranging between 2-60 months (mean 19...
May 19, 2018: BJU International
https://www.readbyqxmd.com/read/29777595/a-ring-based-compensator-imrt-system-optimized-for-low-and-middle-income-countries-design-and-treatment-planning-study
#19
Jonathon Van Schelt, Daniel Smith, Nicholas Fong, Dolla Toomeh, Patricia A Sponseller, Derek W Brown, Meghan W Macomber, Nina A Mayr, Shilpen Patel, Adam Shulman, G V Subrahmanyam, K Govindarajan, Eric C Ford
PURPOSE: We propose a novel compensator-based IMRT system designed to provide a simple, reliable, and cost-effective adjunct technology, with the goal of expanding global access to advanced radiotherapy techniques. The system would employ easily-reusable tungsten bead compensators that operate independent of a gantry (e.g. mounted in a ring around the patient). Thereby the system can be retrofitted to existing linac and cobalt teletherapy units. This study explores the quality of treatment plans from the proposed system and the dependence on associated design parameters...
May 19, 2018: Medical Physics
https://www.readbyqxmd.com/read/29777590/boosting-mediated-electron-transfer-in-bioelectrochemical-systems-with-tailored-defined-microbial-co-cultures
#20
Simone Schmitz, Miriam A Rosenbaum
Bioelectrochemical systems (BES) hold great promise for sustainable energy generation via a microbial catalyst from organic matter, e.g., from wastewater. In order to improve current generation in BES, understanding the underlying microbiology of the electrode community is essential. Electron mediator producing microorganism like Pseudomonas aeruginosa play an essential role in efficient electricity generation in BES. These microbes enable even non-electroactive microorganism like Enterobacter aerogenes to contribute to current production...
May 19, 2018: Biotechnology and Bioengineering
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