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https://www.readbyqxmd.com/read/28607662/clinical-and-endoscopic-findings-of-children-hospitalized-in-qa-em-hospital-of-mashhad-due-to-caustic-ingestion-2011-2013
#1
Alireza Sabzevari, Gholamali Maamouri, Mohammad Ali Kiani, Masumeh Saeidi, Hamidreza Kianifar, Seyed Ali Jafari, Hamid Ahanchian, Lida Jarahi, Elham Roudi, Mohammad Sharafkhani
INTRODUCTION: One of the leading causes of damage to the gastrointestinal tract in children is caustic ingestion which is sometimes life-threatening. The most reliable way to study the severity and extent of damage is endoscopy, which can be harmless in terms of time and technique. The aim of this study was to investigate, evaluate and compare clinical findings and endoscopic results of caustic ingestion. METHODS: This retrospective cross-sectional study was conducted on the records of children diagnosed with caustic ingestion, and hospitalized in Qa'em Hospital of Mashhad from March 2011 to December 2013...
April 2017: Electronic Physician
https://www.readbyqxmd.com/read/28533917/management-of-esophageal-caustic-injury
#2
EDITORIAL
Mark Anthony A De Lusong, Aeden Bernice G Timbol, Danny Joseph S Tuazon
Ingestion of caustic substances and its long-term effect on the gastrointestinal system maintain its place as an important public health issue in spite of the multiple efforts to educate the public and contain its growing number. This is due to the ready availability of caustic agents and the loose regulatory control on its production. Substances with extremes of pH are very corrosive and can create severe injury in the upper gastrointestinal tract. The severity of injury depends on several aspects: Concentration of the substance, amount ingested, length of time of tissue contact, and pH of the agent...
May 6, 2017: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28502435/caustic-ingestions-and-foreign-bodies-ingestions-in-pediatric-patients
#3
REVIEW
Jacob A Kurowski, Marsha Kay
Children inevitably swallow foreign material accidentally or intentionally. Each type of ingestion carries their own set of risks and complications, short and long term, some requiring immediate attention while others close monitoring. Alkalotic household cleaning products and lithium button batteries are increasingly common and damage the esophagus quickly. While many toys with rare-earth metals are banned, they are already present in many households and can cause necrosis of bowel that is between the magnets...
June 2017: Pediatric Clinics of North America
https://www.readbyqxmd.com/read/28451845/reflux-esophagitis-and-its-role-in-the-pathogenesis-of-barrett-s-metaplasia
#4
REVIEW
Rhonda Frances Souza
Reflux esophagitis damages the squamous epithelium that normally lines the esophagus, and promotes replacement of the damaged squamous lining by the intestinal metaplasia of Barrett's esophagus, the precursor of esophageal adenocarcinoma. Therefore, to prevent the development of Barrett's metaplasia and esophageal adenocarcinoma, the pathogenesis of reflux esophagitis must be understood. We have reported that reflux esophagitis, both in a rat model and in humans, develops as a cytokine-mediated inflammatory injury (i...
April 27, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28343609/very-late-onset-dabigatran-induced-esophageal-injury
#5
Ko Fujikawa, Nobuhiro Takasugi, Tadao Goto, Shinya Minatoguchi
An 87-year-old man with persistent atrial fibrillation experienced heartburn and dysphagia at 2 years 9 months after initiation of dabigatran. An esophagogastroduodenoscopy demonstrated multiple longitudinal white plaques with ulcers in the narrowed midesophagus compressed between the left atrium and the tortuous aorta. We speculate that the esophageal stenosis contributed to stasis of dabigatran within the esophagus, resulting in prolonged mucosal contact with the caustic contents of the drug. Progressive enlargement of the left atrium may have led to the late onset of the potentially serious complication...
April 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28340493/conservative-treatment-with-octreotide-to-provide-early-recovery-of-children-with-esophageal-perforation
#6
Ramazan Karabulut, Zafer Turkyilmaz, Kaan Sonmez, Abdullah Can Basaklar
Background The effectiveness of nonoperative treatment of esophageal perforation (EP) in children with octreotide is highlighted. Methods Records of nine patients (seven boys and two girls with an average age of 5.83 ± 5.35 years) with EP were reviewed. Results EP developed in six patients during dilation of esophageal stenosis (five of six caused by caustic burns). In the other three patients, EP developed after nasogastric placement, after endotracheal intubation, and during endoscopy for foreign body...
March 24, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28216076/total-esophageal-substitution-for-combined-hypopharyngeal-and-esophageal-strictures-after-corrosive-injury-in-children
#7
Ana Cristina Aoun Tannuri, Uenis Tannuri
BACKGROUND/PURPOSE: The treatment of children with esophageal strictures and involvement of the hypopharynx caused by caustic substance ingestion continues to be challenging. The aims of the present study are to describe the peculiarities of the technique of complete esophageal substitution for the treatment of children with severe caustic strictures (pharyngocoloplasties) and to compare the results to those of classical esophagocoloplasty with thoracic and abdominal esophageal substitution in another group of children...
February 12, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27911065/-gastric-tube-esophagoplasty-using-the-retroesternal-route-in-children
#8
L García Martínez, J A Molino Gahete, S Redecillas Ferreiro, E Bordón Cabrera, J Bueno Recio, G Guillén Burrieza, C Giné Prades, A Lara Valtueña, J Lloret Roca
INTRODUCTION: Esophageal replacement is a surgical alternative once native esophagus can't be preserved. Different organs and routes for the replacement have been described, being the retroesternal route the least used. The aim is to present our results using gastric tube esophagoplasty with a retroesternal approach. PATIENTS AND METHODS: We performed a retrospective and descriptive study of 11 patients operated from 2000 to 2015. Median age at surgery was 2.2 years (5 months-9 years) and median weight was 11...
January 25, 2016: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/27859311/basic-mechanism-of-button-battery-ingestion-injuries-and-novel-mitigation-strategies-after-diagnosis-and-removal
#9
Kris R Jatana, Keith Rhoades, Scott Milkovich, Ian N Jacobs
OBJECTIVES/HYPOTHESIS: Button battery (BB) injuries continue to be a significant source of morbidity and mortality, and there is a need to confirm the mechanism of injury for development of additional mitigation strategies. STUDY DESIGN: Cadaveric piglet esophageal model. METHODS: Lithium, silver oxide, alkaline, and zinc-air BBs were placed in thawed sections of cadaveric piglet esophagus, bathed in normal saline. Severity of gross visual burn, pH, and temperature were recorded every 30 minutes for 6 hours...
June 2017: Laryngoscope
https://www.readbyqxmd.com/read/27738603/corrosive-esophagitis-with-benzalkonium-chloride-in-a-two-days-old-neonate
#10
Hasret Ayyildiz Civan, Didem Gulcu, Tulay Erkan
Benzalkonium chloride (BAC) is a caustic agent which is used in farms, homes and hospitals for cleaning skin and wounds as an antiseptic solution. It may lead to digestive system injuries in case of ingestion. We present a two-days-old newborn case which was carried to the emergency unit with complaints of poor breastfeeding, uneasiness and crying for 4-6 hours. Her mom confessed that she had given a spoon of 10% BAC solution for her cough. Initial laboratory tests were in normal ranges. A gastroscopy performed in the second hour of her admission revealed an hyperemic and edematous mucosa in the middle third of esophagus and a circumferential ulceration followed in the distal portion...
September 2016: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/27708180/mid-esophagus-columnar-metaplasia
#11
Inês Rolim, Rita Vale Rodrigues, António Bettencourt, Rita Barros, Vânia Camilo, António Dias Pereira, Raquel Almeida, Paula Chaves
We report a case of metaplastic columnar epithelium in the mid-esophagus in a patient with history of caustic ingestion. A cardiac-type gastric phenotype, with early signs of intestinalization, was confirmed by immunohistochemistry studies (MUC5AC, MUC6, SOX2, and CDX2). Nonmetaplastic mucosa had histologic evidence of gastroesophageal reflux. In this case, esophageal reepithelization seems to have been modulated by acidic gastroesophageal reflux, which might activate transcription factors leading to phenotypic reprogramming of the regenerative epithelium...
October 1, 2016: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27409090/-caustics-injuries-in-the-upper-gastrointestinal-tract-clinical-and-endoscopic-features
#12
Briny Omar Rodríguez Vargas, Eduardo Monge Salgado, Pedro Montes Teves, Sonia Salazar Ventura, Edson Guzmán Calderón
OBJECTIVE: To describe the clinical and endoscopic features of caustics injuries in the upper gastrointestinal tract in patients of the National Hospital Daniel Alcides Carrión. MATERIALS AND METHODS: A descriptive study was conducted; the study populations were patients diagnosed with caustic ingestion who were admitted into the Gastroenterology service of the HNDAC to perform an upper endoscopy during the period of January 2009 to December 2012. We documented the type of caustic substance ingested, cause of intake, amount ingested, intake mode, signs or symptoms present, endoscopic findings as classified by Zargar, presence of complications and treatment performed...
April 2016: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/27394396/esophageal-remnant-cancer-35-years-after-acidic-caustic-injury-a-case-report
#13
Ioannis Ntanasis-Stathopoulos, Stamatina Triantafyllou, Vasiliki Xiromeritou, Nikolaos Bliouras, Chriso Loizou, Dimitrios Theodorou
INTRODUCTION: Esophageal squamous cell carcinoma has been described as a long-term consequence following ingestion of corrosive substances. PRESENTATION OF CASE: We report a rare case of a 62-year-old female patient with a history of acidic caustic injury 35 years ago, for which she had undergone near total esophagogastrectomy with right colon interposition. Recently, she presented with worsening dysphagia, weight loss, neck swelling and chest pain. After the diagnostic workup, an invasive squamous cell carcinoma of the esophagus was confirmed...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27331918/from-reflux-esophagitis-to-esophageal-adenocarcinoma
#14
REVIEW
Rhonda F Souza
Reflux esophagitis causes Barrett's metaplasia, an abnormal esophageal mucosa predisposed to adenocarcinoma. Medical therapy for reflux esophagitis focuses on decreasing gastric acid production with proton pump inhibitors. We have reported that reflux esophagitis in a rat model develops from a cytokine-mediated inflammatory injury, not from a caustic chemical (acid) injury. In this model, refluxed acid and bile stimulate the release of inflammatory cytokines from esophageal squamous cells, recruiting lymphocytes first to the submucosa and later to the luminal surface...
2016: Digestive Diseases
https://www.readbyqxmd.com/read/27260570/swallowing-dynamics-status-post-caustic-ingestion-in-a-pediatric-patient-a-multidisciplinary-case-report
#15
Claire Kane Miller, Michael J Rutter, Daniel von Allmen, Marilyn Stoops, Philip Putnam, Luann Stevens, J Paul Willging
A case report of a 10 year old male illustrates the effect of damage to the tongue base, hypopharynx, cricopharyngeus, and esophagus on the sensory and motor components of the swallowing mechanism. The characteristics of the dysphagia were manifested clinically, radiographically, and endoscopically. A myectomy was required to restore functional swallowing as scar tissue formation in the cricopharyngeus severely interfered with the dynamic components of swallowing. A collaborative approach facilitated communication and effective treatment planning; the multidisciplinary components in the management of this case are discussed...
July 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27200129/-endoscopic-contribution-in-the-dilatation-of-caustic-esophagus-stenosis
#16
COMPARATIVE STUDY
Togo Seydou, Ouattara Moussa Abdoulaye, Li Xing, Sanogo Zimogo Zi, Koumaré Sekou, Yang Shang Wen, Sankare Ibrahim, Toure Cheik Ahmed Sekou, Maiga Ibrahim Boubacar, Jacque Saye, Dakouo Dodino Jerome, Toure Ousmane Dantoumé, Yena Sadio
INTRODUCTION: The aim of this work was to present the contribution of the endoscopy in the management of esophageal dilatation for caustic esophageal stenosis (CES). METHODS: This was a descriptive and prospective study in the thoracic surgery department at the Hospital of Mali. A total of 46 cases of CES is recorded and divided into 4 groups according to the topography of the esophageal lesions. For the different methods of dilatation the number of performed endoscopic support was determined to understand the contribution of endoscopic means in the success of dilatation for CES...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27197994/clinical-spectrum-and-management-of-caustic-ingestion-a-case-series-presenting-three-opposing-outcomes
#17
Antonios I Vezakis, Eirini V Pantiora, Elissaios A Kontis, Vasileios Sakellariou, Dimitrios Theodorou, Georgios Gkiokas, Andreas A Polydorou, Georgios P Fragulidis
BACKGROUND: Ingestion of caustic substances is a medical emergency in both the adult and pediatric population and is associated with high morbidity and mortality. The extent of injuries after ingestion of caustic substances depends on the nature, amount, and concentration of the agent and on the exposure time. Acutely, caustic substances may cause massive hemorrhage and gastrointestinal tract perforation; the most markedly affected cases require urgent surgical treatment. Patients surviving the initial event may present with aorto-enteric or gastrocolic fistulae, esophageal strictures, dysphagia, and increased risk of esophageal cancer as long term sequelae...
May 20, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/26989301/autopsy-results-of-a-case-of-ingestion-of-sodium-hydroxide-solution
#18
Yuko Emoto, Katsuhiko Yoshizawa, Nobuaki Shikata, Airo Tsubura, Yasushi Nagasaki
Sodium hydroxide is a strongly corrosive alkali. We describe herein a case of suicide by ingestion of sodium hydroxide. A man in his 80s was found dead with a mug and a bottle of caustic soda. Macroscopically, liquefaction and/or disappearance of esophagus, trachea and lung tissue and a grayish discoloration of the mucosa of the stomach were seen along with blackish brown coloration of the skin, mouth, and oral cavity. The contents of the gastrointestinal tract showed a pH level of 7-8 on pH indicator strips...
January 2016: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/26920407/the-damage-pattern-to-the-gastrointestinal-tract-depends-on-the-nature-of-the-ingested-caustic-agent
#19
Romain Ducoudray, Antoine Mariani, Helene Corte, Aurore Kraemer, Nicolas Munoz-Bongrand, Emile Sarfati, Pierre Cattan, Mircea Chirica
BACKGROUND: The mechanisms of damage to the gastrointestinal tract after caustic ingestion are conditioned by the nature of the ingested agent. Whether the nature of the ingested agent has a direct influence on patient outcomes is unknown. METHODS: From January 2013 to April 2015, 144 patients underwent emergency management for caustic injuries at the Saint Louis Hospital in Paris. There were 51 men (51 %) and the median age was 44 years [39, 48]. The ingested agents were soda-based strong alkali in 85 patients (59 %), strong acids in 36 patients (25 %), and bleach in 23 patients (16 %)...
July 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/26158162/long-term-results-of-esophageal-bypass-for-corrosive-strictures-without-esophageal-resection-using-a-modified-left-colon-esophagocoloplasty-a-report-of-105-consecutive-patients-from-a-single-unit-over-30-years
#20
Nilakantan Ananthakrishnan, Kasturi S V K Subbarao, Govindraj Parthasarathy, Vikram Kate, Raja Kalayarasan
BACKGROUND/AIMS: Esophageal stricture due to corrosive ingestion is a common cause of benign esophageal obstruction in developing countries. The immediate and long-term results of surgical bypass using a modification of the left colon conduit, will be reviewed. METHODOLOGY: From 1977 to 2008, 105 patients underwent esophageal bypass for corrosive esophageal strictures using this procedure which has several modifications, detailed in the text, from the conventional left colon conduit...
June 2014: Hepato-gastroenterology
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