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https://www.readbyqxmd.com/read/27697885/the-history-of-galaflex-p4hb-scaffold
#1
Simon F Williams, David P Martin, Arikha C Moses
The GalaFLEX Scaffold (Galatea Surgical, Inc., Lexington, MA) for plastic and reconstructive surgery belongs to a new generation of products for soft tissue reinforcement made from poly-4-hydroxybutyrate (P4HB). Other members of this new family of products include MonoMax Suture (Aesculap AG, Tuttlingen, Germany) for soft tissue approximation, BioFiber Scaffold (Tornier, Inc., Edina, MN) for tendon repair, and Phasix Mesh (C.R. Bard, Inc., Murray Hill, NJ) for hernia repair. Each of these fully resorbable products provides prolonged strength retention, typically 50% to 70% strength retention at 12 weeks, and facilitates remodeling in vivo to provide a strong, lasting repair...
October 3, 2016: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/27595188/reducing-postoperative-abdominal-bulge-following-deep-inferior-epigastric-perforator-flap-breast-reconstruction-with-onlay-monofilament-poly-4-hydroxybutyrate-biosynthetic-mesh
#2
Blair A Wormer, Nicholas W Clavin, Jean-Francois Lefaivre, Jason M Korn, Edward Teng, Anthony S Aukskalnis, J Michael Robinson
Background The purpose of this study was to evaluate the use of a biosynthetic mesh onlay on reducing postoperative abdominal bulge following deep inferior epigastric perforator (DIEP) flap breast reconstruction. Methods All patients undergoing DIEP reconstructions from January, 2010 to January, 2014 at a tertiary center were reviewed. Patients were divided into two groups for comparison based on whether a biosynthetic mesh onlay (Phasix [monofilament poly-4-hydroxybutyrate], Bard Inc., Warwick, RI) was used for reinforcement of the anterior rectus fascia...
September 5, 2016: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/27369286/evaluation-of-a-fully-absorbable-poly-4-hydroxybutyrate-absorbable-barrier-composite-mesh-in-a-porcine-model-of-ventral-hernia-repair
#3
Jeffrey R Scott, Corey R Deeken, Robert G Martindale, Michael J Rosen
BACKGROUND: The objective of this study was to evaluate the mechanical and histological properties of a fully absorbable poly-4-hydroxybutyrate/absorbable barrier composite mesh (Phasix™ ST) compared to partially absorbable (Ventralight™ ST), fully absorbable (Phasix™), and biologically derived (Strattice™) meshes in a porcine model of ventral hernia repair. METHODS: Bilateral abdominal surgical defects were created in twenty-four Yucatan pigs, repaired with intraperitoneal (Phasix™ ST, Ventralight™ ST) or retromuscular (Phasix™, Strattice™) mesh, and evaluated at 12 and 24 weeks (n = 6 mesh/group/time point)...
September 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/23781348/characterization-of-the-mechanical-strength-resorption-properties-and-histologic-characteristics-of-a-fully-absorbable-material-poly-4-hydroxybutyrate-phasix-mesh-in-a-porcine-model-of-hernia-repair
#4
Corey R Deeken, Brent D Matthews
Purpose. Poly-4-hydroxybutyrate (P4HB) is a naturally derived, absorbable polymer. P4HB has been manufactured into PHASIX Mesh and P4HB Plug designs for soft tissue repair. The objective of this study was to evaluate mechanical strength, resorption properties, and histologic characteristics in a porcine model. Methods. Bilateral defects were created in the abdominal wall of n = 20 Yucatan minipigs and repaired in a bridged fashion with PHASIX Mesh or P4HB Plug fixated with SorbaFix or permanent suture, respectively...
2013: ISRN Surgery
https://www.readbyqxmd.com/read/23582230/characterization-of-poly-4-hydroxybutyrate-mesh-for-hernia-repair-applications
#5
David P Martin, Amit Badhwar, Devang V Shah, Said Rizk, Stephen N Eldridge, Darcy H Gagne, Amit Ganatra, Roger E Darois, Simon F Williams, Hsin-Chien Tai, Jeffrey R Scott
BACKGROUND: Phasix mesh is a fully resorbable implant for soft tissue reconstruction made from knitted poly-4-hydroxybutyrate monofilament fibers. The objectives of this study were to characterize the in vitro and in vivo mechanical and resorption properties of Phasix mesh over time, and to assess the functional performance in a porcine model of abdominal hernia repair. MATERIALS AND METHODS: We evaluated accelerated in vitro degradation of Phasix mesh in 3 mol/L HCl through 120 h incubation...
October 2013: Journal of Surgical Research
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