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adverse reactions corticosteroid injections

Henri Traboulsi, Tamer El Natout, Ghassan Skaff, Abdul-Latif Hamdan
INTRODUCTION: Injection laryngoplasty using hyaluronic acid is a safe procedure commonly performed on patients with glottic insufficiency. STUDY DESIGN: This is a descriptive study of a case of adverse reaction to hyaluronic acid in a patient who underwent injection laryngoplasty for the treatment of unilateral vocal cord paralysis. DISCUSSION: The patient was treated with antibiotics and corticosteroids and had a full recovery. The authors recommend close observation following injection laryngoplasty using hyaluronic acid and diligent investigation of persistent postoperative laryngopharyngeal symptoms...
October 21, 2016: Journal of Voice: Official Journal of the Voice Foundation
Annick Barbaud, Julie Waton
Systemic hypersensitivity (HS) to corticosteroids (CS) is paradoxical but does exist. Some patients with a previous contact allergy to topical CS may develop a systemic contact dermatitis (SCD) while receiving CS orally or intravenously. However, a previous contact sensitization is not mandatory for developing a systemic HS to CS. Acute or delayed urticaria can occur in immediate HS. Immediate HS can be due to excipients, mainly carboxymethylcellulose or to CS themselves. Delayed reactions, mainly maculopapular rash and acute generalized exanthematous pustulosis can occur...
October 12, 2016: Current Pharmaceutical Design
S A S van der Bent, A Wolkerstorfer, T Rustemeyer
INTRODUCTION: Tattooing involves the introduction of exogenous pigment into the dermis. Worldwide, tattoos are one of the most popular forms of permanent body art. In the Netherlands, 8-10% of the population older than 12 years old has a tattoo. A wide variety of cutaneous adverse effects can occur in tattoos, these can cause serious symptoms. However, recognition and appropriate knowledge of diagnosis and treatment is still frequently insufficient in many medical practitioners. CASE DESCRIPTION: The first case concerns a 57-year-old female, who developed an itching swelling in the red part of a tattoo on the left arm...
2016: Nederlands Tijdschrift Voor Geneeskunde
Sally Wenzel, Mario Castro, Jonathan Corren, Jorge Maspero, Lin Wang, Bingzhi Zhang, Gianluca Pirozzi, E Rand Sutherland, Robert R Evans, Vijay N Joish, Laurent Eckert, Neil M H Graham, Neil Stahl, George D Yancopoulos, Mariana Louis-Tisserand, Ariel Teper
BACKGROUND: Dupilumab, a fully human anti-interleukin-4 receptor α monoclonal antibody, inhibits interleukin-4 and interleukin-13 signalling, key drivers of type-2-mediated inflammation. Adults with uncontrolled persistent asthma who are receiving medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist require additional treatment options as add-on therapy. We aimed to assess the efficacy and safety of dupilumab as add-on therapy in patients with uncontrolled persistent asthma on medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist, irrespective of baseline eosinophil count...
July 2, 2016: Lancet
Leonardo Osti, Matteo Buda, Angelo Del Buono, Raffaella Osti, Leo Massari
PURPOSE: the aim of this quantitative review is to document potential benefit and adverse effects of hyaluronic acid (HA) injection into the shoulder with rotator cuff tears. METHODS: a systematic literature search was performed in english PubMed, Medline, Ovid, Google Scholar and Embase databases using the combined key words "hyaluronic acid", "rotator cuff tear", "hyaluronate", "shoulder", "viscosupplementation", with no limit regarding the year of publication...
October 2015: Muscles, Ligaments and Tendons Journal
Minish M Jain, Smita U Gupte, Shekhar G Patil, Anand B Pathak, Chetan D Deshmukh, Niraj Bhatt, Chiramana Haritha, K Govind Babu, Shailesh A Bondarde, Raghunadharao Digumarti, Jyoti Bajpai, Ravi Kumar, Ashish V Bakshi, Gouri Sankar Bhattacharya, Poonam Patil, Sundaram Subramanian, Ashok K Vaid, Chirag J Desai, Ajay Khopade, Geetanjali Chimote, Poonamalle P Bapsy, Shravanti Bhowmik
Paclitaxel is widely used in the treatment of patients with metastatic breast cancer (MBC). Formulations of paclitaxel contain surfactants and solvents or albumin derived from human blood. The use of co-solvents such as polyoxyethylated castor oil is thought to contribute to toxicity profile and hypersensitivity reactions as well as leaching of plasticizers from polyvinyl chloride bags and infusion sets. Currently, nab-paclitaxel, an albumin-bound paclitaxel in nanometer range continues to be the preferred taxane formulation used in clinic...
February 2016: Breast Cancer Research and Treatment
Matthew Newman, Midhun Malla, Ivana Gojo
STUDY OBJECTIVE: To describe three cases of pericarditis probably related to azacitidine administration in a span of 3 years at our center. DESIGN: Case series. SETTING: Comprehensive cancer center within a large, academic medical center. PATIENTS: Three patients with high-grade myelodysplastic syndrome or acute myeloid leukemia who received azacitidine. INTERVENTION: None. MEASUREMENTS: None...
April 2016: Pharmacotherapy
Claus Bachert, Leda Mannent, Robert M Naclerio, Joaquim Mullol, Berrylin J Ferguson, Philippe Gevaert, Peter Hellings, Lixia Jiao, Lin Wang, Robert R Evans, Gianluca Pirozzi, Neil M Graham, Brian Swanson, Jennifer D Hamilton, Allen Radin, Namita A Gandhi, Neil Stahl, George D Yancopoulos, E Rand Sutherland
IMPORTANCE: Dupilumab has demonstrated efficacy in patients with asthma and atopic dermatitis, which are both type 2 helper T-cell-mediated diseases. OBJECTIVE: To assess inhibition of interleukins 4 and 13 with dupilumab in patients with chronic sinusitis and nasal polyposis. DESIGN, SETTING, AND PARTICIPANTS: A randomized, double-blind, placebo-controlled parallel-group study conducted at 13 sites in the United States and Europe between August 2013 and August 2014 in 60 adults with chronic sinusitis and nasal polyposis refractory to intranasal corticosteroids with 16 weeks of follow-up...
February 2, 2016: JAMA: the Journal of the American Medical Association
Katie Beleznay, Jean D A Carruthers, Alastair Carruthers, Mark E Mummert, Shannon Humphrey
BACKGROUND: The shift from 2- to 3-dimensional soft tissue augmentation has allowed the development of hyaluronic acid (HA) fillers, which are long lasting and also reversible. Delayed-onset inflammatory nodules have recently been reported with the use of HA fillers. OBJECTIVE: The authors document their experience with delayed-onset nodules after 3-dimensional facial injection of Juvéderm Voluma (HA-V) over 68 months. MATERIALS AND METHODS: The authors conducted a retrospective chart review of patients who were treated with HA-V between February 1, 2009, and September 30, 2014, to evaluate for delayed-onset nodules...
August 2015: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Christopher Plastaras, Zachary L McCormick, Cynthia Garvan, Donald Macron, Anand Joshi, Gary Chimes, Wesley Smeal, Joshua Rittenberg, David J Kennedy
BACKGROUND CONTEXT: Although the types and incidence of adverse events (AEs) associated with transforaminal epidural steroid injection (TFESI) have been described, no study has used a systematic standardized questionnaire to solicit AEs from patients to capture an accurate range and incidence of complications. PURPOSE: The aim was to systematically identify the types and incidence of AEs associated with TFESI. Additionally, this study evaluated demographic and clinical factors that may predict a higher risk of an AE...
October 1, 2015: Spine Journal: Official Journal of the North American Spine Society
Mariana Figueiroa Careta, Livia Delgado, Régia Patriota
UNLABELLED: Botulinum toxin is a widely used treatment with satisfactory results, and it is relatively safe in the doses used for cosmetic procedures. The authors report a case of allergic reaction to Chinese botulinum toxin serotype A (CBTX-A). Although this is a rare adverse event, it is nonetheless clinically relevant to healthcare professionals. A 44-year-old woman presented to the authors' hospital complaining of dynamic wrinkles. CBTX-A was used to treat her. Minutes after application, she developed urticarial plaques proximal to the injection site...
July 2015: Aesthetic Surgery Journal
Alexandre Matet, Alejandra Daruich, Talal Beydoun, Jacques Cosnes, Jean-Louis Bourges
BACKGROUND: Tumor necrosis factor-alpha inhibitors are widely used agents in the treatment of immune disorders such as rheumatoid arthritis and inflammatory bowel disease. Despite their anti-inflammatory action, paradoxical drug-induced inflammatory events have been occasionally associated with the use of infliximab, etanercept, and in a lesser extent adalimumab. However, eye involvement is uncommon and anterior uveitis is the only reported ocular adverse manifestation. It can be induced by etanercept, but has also been described during adalimumab therapy...
2015: BMC Ophthalmology
Kirk A Campbell, Bryan M Saltzman, Randy Mascarenhas, M Michael Khair, Nikhil N Verma, Bernard R Bach, Brian J Cole
PURPOSE: The aims of this study were (1) to perform a systematic review of meta-analyses evaluating platelet-rich plasma (PRP) injection in the treatment of knee joint cartilage degenerative pathology, (2) to provide a framework for analysis and interpretation of the best available evidence to provide recommendations for use (or lack thereof) of PRP in the setting of knee osteoarthritis (OA), and (3) to identify literature gaps where continued investigation would be suggested. METHODS: Literature searches were performed for meta-analyses examining use of PRP versus corticosteroids, hyaluronic acid, oral nonsteroidal anti-inflammatory drugs, or placebo...
November 2015: Arthroscopy: the Journal of Arthroscopic & related Surgery
Muhammad Akram, Muhammad Latif Shahzad, Faheem Mubashir Farooqi, Muhammad Irshad, Ranjeet Kumar Sah, Syed Muhammad Awais
BACKGROUND: De Quervain's tenosynovitis is defined as stenosing tenosynovitis of the synovial sheath of tendons of abductor polices longus and extensor pollicis brevis in the first compartment of wrist due to repetitive use. OBJECTIVE: To assess the results of injecting corticosteroids injections for De Quervain's tenosynovitis. METHODS: 80 patients with disease were included in this study. All had a mean of 5.87 weeks of treatment of the condition with NSAIDs and had shown no response...
December 2014: JPMA. the Journal of the Pakistan Medical Association
Aurelia Trisliana Perdanasari, Davide Lazzeri, Weijie Su, Wenjing Xi, Zhang Zheng, Li Ke, Peiru Min, Shaoqing Feng, Yi Xin Zhang, Paolo Persichetti
Keloid scars are often considered aesthetically unattractive and frustrating problems that occur following injuries. They cause functional and cosmetic deformities, displeasure, itching, pain, and psychological stress and possibly affect joint movement. The combination of these factors ultimately results in a compromised quality of life and diminished functional performance. Various methods have been implemented to improve keloid scars using both surgical and non-surgical approaches. However, it has proven to be a challenge to identify a universal treatment that can deliver optimal results for all types of scars...
November 2014: Archives of Plastic Surgery
Mario Castro, Sally E Wenzel, Eugene R Bleecker, Emilio Pizzichini, Piotr Kuna, William W Busse, David L Gossage, Christine K Ward, Yanping Wu, Bing Wang, Deepak B Khatry, René van der Merwe, Roland Kolbeck, Nestor A Molfino, Donald G Raible
BACKGROUND: Persistent eosinophilic airway inflammation in asthma increases the risk of exacerbations. In a phase 2b dose-ranging study, we aimed to assess the efficacy and safety of benralizumab, an anti-interleukin 5 receptor α monoclonal antibody that depletes blood and airway eosinophils, in adults with uncontrolled eosinophilic asthma. METHODS: We did a randomised, controlled, double-blind, dose-ranging phase 2b study. Eligible participants were adults aged 18-75 years with uncontrolled asthma using medium-dose or high-dose inhaled corticosteroids and longacting β agonists, with two to six exacerbations in the past year...
November 2014: Lancet Respiratory Medicine
Murat Tonbul, Mujdat Adas, Taner Bekmezci, Ahmet Duran Kara
Osteoarthritis is a chronic disorder characterized by joint cartilage degeneration with concomitant changes in the synovium and subchondral bone metabolism. Many conservative treatment modalities, one of which is intra-articular injections, have been described for the treatment of this disorder. Traditionally, hyaluranic acid and corticosteroids are the agents that have been used for this purpose. Recently, polyacrylamide hydrogels are being used widely. Biocompatibility, nonbioabsorbability, and anti-infectious effect obtained by silver addition made polyacrylamide hydrogels more popular...
2014: Case Reports in Orthopedics
Chris Plastaras, Zachary McCormick, Donald Macron, Cynthia Garvan, Anand Joshi, Gary Chimes, Wesley Smeal, Joshua Rittenberg
BACKGROUND: In spite of the widespread performance of intra-articular zygapophyseal joint (IAZJ) injections, we know of no systematic analysis to date that examines the risks and types of adverse events when IAZJ injections are performed. OBJECTIVE: To describe the type, incidence, and factors contributing to adverse events associated with fluoroscopically guided IAZJ injections. STUDY DESIGN: A retrospective, cohort study of English-speaking adults aged 18 - 90 years who underwent fluoroscopically guided IAZJ injections between March 8, 2004, and April 19, 2007...
July 2014: Pain Physician
Ernst A Chantelau, Ruth Prätor, Jörg Prätor
INTRODUCTION: Localized involutional lipoatrophy of subcutaneous adipose tissue may develop due to subcutaneous injection of pharmaceutical preparations. The pathogenesis of this adverse drug reaction is unknown. The progression of localized involutional lipoatrophy ceases and occasionally it resolves after withdrawing the inducing agent. In case of localized involutional lipoatrophy due to subcutaneous insulin therapy, low-dose systemic corticosteroids may be curative despite ongoing insulin administration...
2014: Journal of Medical Case Reports
Sheikh Javeed Sultan, Farah Sameem, Mohd Ashraf
BACKGROUND: Drug-induced hypersensitivity syndrome (DIHS) or drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare type of adverse drug reaction with complex clinical features involving multiple systems of the body. OBJECTIVES: This study was designed to evaluate the clinical features, course, response to treatment, and outcome of DRESS. METHODS: The study involved a retrospective analysis of data collected over a period of four years in 17 patients with DRESS...
2015: International Journal of Dermatology
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