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optogenetics, dopamine, neurotransmitter

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https://www.readbyqxmd.com/read/27548680/dopamine-dynamics-during-continuous-intracranial-self-stimulation-effect-of-waveform-on-fast-scan-cyclic-voltammetry-data
#1
Nathan T Rodeberg, Justin A Johnson, Elizabeth S Bucher, R Mark Wightman
The neurotransmitter dopamine is heavily implicated in intracranial self-stimulation (ICSS). Many drugs of abuse that affect ICSS behavior target the dopaminergic system, and optogenetic activation of dopamine neurons is sufficient to support self-stimulation. However, the patterns of phasic dopamine release during ICSS remain unclear. Early ICSS studies using fast-scan cyclic voltammetry (FSCV) rarely observed phasic dopamine release, which led to the surprising conclusion that it is dissociated from ICSS...
September 1, 2016: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/26973593/age-related-neurochemical-changes-in-the-vestibular-nuclei
#2
REVIEW
Paul F Smith
There is evidence that the normal aging process is associated with impaired vestibulo-ocular reflexes (VOR) and vestibulo-spinal reflexes, causing reduced visual acuity and postural instability. Nonetheless, the available evidence is not entirely consistent, especially with respect to the VOR. Some recent studies have reported that VOR gain can be intact even above 80 years of age. Similarly, although there is evidence for age-related hair cell loss and neuronal loss in Scarpa's ganglion and the vestibular nucleus complex (VNC), it is not entirely consistent...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/26286655/reward-processing-by-the-dorsal-raphe-nucleus-5-ht-and-beyond
#3
REVIEW
Minmin Luo, Jingfeng Zhou, Zhixiang Liu
The dorsal raphe nucleus (DRN) represents one of the most sensitive reward sites in the brain. However, the exact relationship between DRN neuronal activity and reward signaling has been elusive. In this review, we will summarize anatomical, pharmacological, optogenetics, and electrophysiological studies on the functions and circuit mechanisms of DRN neurons in reward processing. The DRN is commonly associated with serotonin (5-hydroxytryptamine; 5-HT), but this nucleus also contains neurons of the neurotransmitter phenotypes of glutamate, GABA and dopamine...
September 2015: Learning & Memory
https://www.readbyqxmd.com/read/26235617/depression-of-serotonin-synaptic-transmission-by-the-dopamine-precursor-l-dopa
#4
Stephanie C Gantz, Erica S Levitt, Nerea Llamosas, Kim A Neve, John T Williams
Imbalance between the dopamine and serotonin (5-HT) neurotransmitter systems has been implicated in the comorbidity of Parkinson's disease (PD) and psychiatric disorders. L-DOPA, the leading treatment of PD, facilitates the production and release of dopamine. This study assessed the action of L-DOPA on monoamine synaptic transmission in mouse brain slices. Application of L-DOPA augmented the D2-receptor-mediated inhibitory postsynaptic current (IPSC) in dopamine neurons of the substantia nigra. This augmentation was largely due to dopamine release from 5-HT terminals...
August 11, 2015: Cell Reports
https://www.readbyqxmd.com/read/26171413/modulating-dopamine-release-by-optogenetics-in-transgenic-mice-reveals-terminal-dopaminergic-dynamics
#5
Yao Lu, Nicolette Driscoll, Ilker Ozden, Zeyang Yu, Arto V Nurmikko
Dopamine (DA) release and uptake dynamics in the nucleus accumbens (NAc) have important implications for neurological diseases and mammalian animal behaviors. We demonstrate here the use of cell-type-specific optogenetic targeting in conjunction with fast-scan cyclic voltammetry applied to brain slices prepared from specifically tailored transgenic mice, which conditionally express channelrhodopsin-2 (ChR2) through dopamine transporter (DAT)-Cre. Terminal dopaminergic dynamics and the direct manipulation of induced DA release level by controlling light intensity, pulse width, and the shape of stimulation waveforms were studied...
July 2015: Neurophotonics
https://www.readbyqxmd.com/read/25962754/cre-driven-optogenetics-in-the-heterogeneous-genetic-panorama-of-the-vta
#6
REVIEW
Stéfano Pupe, Åsa Wallén-Mackenzie
The selectivity of optogenetics commonly relies on genetic promoters to manipulate specific populations of neurons through the use of Cre-driver lines. All studies performed in the ventral tegmental area (VTA) so far have utilized promoters present in groups of cells that release dopamine (DA), GABA, or glutamate. However, neurons that co-release neurotransmitters and variabilities within groups of neurons that release the same neurotransmitter present challenges when evaluating the results. Further complexity is introduced by ectopic expression patterns often occurring in transgenic Cre-drivers...
June 2015: Trends in Neurosciences
https://www.readbyqxmd.com/read/25711512/carbon-nanopipette-electrodes-for-dopamine-detection-in-drosophila
#7
Hillary R Rees, Sean E Anderson, Eve Privman, Haim H Bau, B Jill Venton
Small, robust, sensitive electrodes are desired for in vivo neurotransmitter measurements. Carbon nanopipettes have been previously manufactured and used for single-cell drug delivery and electrophysiological measurements. Here, a modified fabrication procedure was developed to produce batches of solid carbon nanopipette electrodes (CNPEs) with ∼250 nm diameter tips, and controllable lengths of exposed carbon, ranging from 5 to 175 μm. The electrochemical properties of CNPEs were characterized with fast-scan cyclic voltammetry (FSCV) for the first time...
April 7, 2015: Analytical Chemistry
https://www.readbyqxmd.com/read/25447802/nicotinic-glutamatergic-and-dopaminergic-synaptic-transmission-and-plasticity-in-the-mesocorticolimbic-system-focus-on-nicotine-effects
#8
REVIEW
Francesco Pistillo, Francesco Clementi, Michele Zoli, Cecilia Gotti
Cigarette smoking is currently the leading cause of preventable deaths and disability throughout the world, being responsible for about five million premature deaths/year. Unfortunately, fewer than 10% of tobacco users who try to stop smoking actually manage to do so. The main addictive agent delivered by cigarette smoke is nicotine, which induces psychostimulation and reward, and reduces stress and anxiety. The use of new technologies (including optogenetics) and the development of mouse models characterised by cell-specific deletions of receptor subtype genes or the expression of gain-of-function nAChR subunits has greatly increased our understanding of the molecular mechanisms and neural substrates of nicotine addiction first revealed by classic electrophysiological, neurochemical and behavioural approaches...
January 2015: Progress in Neurobiology
https://www.readbyqxmd.com/read/25388237/a-glutamatergic-reward-input-from-the-dorsal-raphe-to-ventral-tegmental-area-dopamine-neurons
#9
Jia Qi, Shiliang Zhang, Hui-Ling Wang, Huikun Wang, Jose de Jesus Aceves Buendia, Alexander F Hoffman, Carl R Lupica, Rebecca P Seal, Marisela Morales
Electrical stimulation of the dorsal raphe (DR) and ventral tegmental area (VTA) activates the fibres of the same reward pathway but the phenotype of this pathway and the direction of the reward-relevant fibres have not been determined. Here we report rewarding effects following activation of a DR-originating pathway consisting of vesicular glutamate transporter 3 (VGluT3) containing neurons that form asymmetric synapses onto VTA dopamine neurons that project to nucleus accumbens. Optogenetic VTA activation of this projection elicits AMPA-mediated synaptic excitatory currents in VTA mesoaccumbens dopaminergic neurons and causes dopamine release in nucleus accumbens...
2014: Nature Communications
https://www.readbyqxmd.com/read/24949967/natural-neural-projection-dynamics-underlying-social-behavior
#10
Lisa A Gunaydin, Logan Grosenick, Joel C Finkelstein, Isaac V Kauvar, Lief E Fenno, Avishek Adhikari, Stephan Lammel, Julie J Mirzabekov, Raag D Airan, Kelly A Zalocusky, Kay M Tye, Polina Anikeeva, Robert C Malenka, Karl Deisseroth
Social interaction is a complex behavior essential for many species and is impaired in major neuropsychiatric disorders. Pharmacological studies have implicated certain neurotransmitter systems in social behavior, but circuit-level understanding of endogenous neural activity during social interaction is lacking. We therefore developed and applied a new methodology, termed fiber photometry, to optically record natural neural activity in genetically and connectivity-defined projections to elucidate the real-time role of specified pathways in mammalian behavior...
June 19, 2014: Cell
https://www.readbyqxmd.com/read/24849718/optogenetic-control-of-serotonin-and-dopamine-release-in-drosophila-larvae
#11
Ning Xiao, Eve Privman, B Jill Venton
Optogenetic control of neurotransmitter release is an elegant method to investigate neurobiological mechanisms with millisecond precision and cell type-specific resolution. Channelrhodopsin-2 (ChR2) can be expressed in specific neurons, and blue light used to activate those neurons. Previously, in Drosophila, neurotransmitter release and uptake have been studied after continuous optical illumination. In this study, we investigated the effects of pulsed optical stimulation trains on serotonin or dopamine release in larval ventral nerve cords...
August 20, 2014: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/24835117/mechanisms-to-medicines-elucidating-neural-and-molecular-substrates-of-fear-extinction-to-identify-novel-treatments-for-anxiety-disorders
#12
REVIEW
Olena Bukalo, Courtney R Pinard, Andrew Holmes
The burden of anxiety disorders is growing, but the efficacy of available anxiolytic treatments remains inadequate. Cognitive behavioural therapy for anxiety disorders focuses on identifying and modifying maladaptive patterns of thinking and behaving, and has a testable analogue in rodents in the form of fear extinction. A large preclinical literature has amassed in recent years describing the neural and molecular basis of fear extinction in rodents. In this review, we discuss how this work is being harnessed to foster translational research on anxiety disorders and facilitate the search for new anxiolytic treatments...
October 2014: British Journal of Pharmacology
https://www.readbyqxmd.com/read/24656254/dorsal-raphe-neurons-signal-reward-through-5-ht-and-glutamate
#13
Zhixiang Liu, Jingfeng Zhou, Yi Li, Fei Hu, Yao Lu, Ming Ma, Qiru Feng, Ju-En Zhang, Daqing Wang, Jiawei Zeng, Junhong Bao, Ji-Young Kim, Zhou-Feng Chen, Salah El Mestikawy, Minmin Luo
The dorsal raphe nucleus (DRN) in the midbrain is a key center for serotonin (5-hydroxytryptamine; 5-HT)-expressing neurons. Serotonergic neurons in the DRN have been theorized to encode punishment by opposing the reward signaling of dopamine neurons. Here, we show that DRN neurons encode reward, but not punishment, through 5-HT and glutamate. Optogenetic stimulation of DRN Pet-1 neurons reinforces mice to explore the stimulation-coupled spatial region, shifts sucrose preference, drives optical self-stimulation, and directs sensory discrimination learning...
March 19, 2014: Neuron
https://www.readbyqxmd.com/read/24613418/striatal-cholinergic-interneurons-drive-gaba-release-from-dopamine-terminals
#14
Alexandra B Nelson, Nora Hammack, Cindy F Yang, Nirao M Shah, Rebecca P Seal, Anatol C Kreitzer
Striatal cholinergic interneurons are implicated in motor control, associative plasticity, and reward-dependent learning. Synchronous activation of cholinergic interneurons triggers large inhibitory synaptic currents in dorsal striatal projection neurons, providing one potential substrate for control of striatal output, but the mechanism for these GABAergic currents is not fully understood. Using optogenetics and whole-cell recordings in brain slices, we find that a large component of these inhibitory responses derive from action-potential-independent disynaptic neurotransmission mediated by nicotinic receptors...
April 2, 2014: Neuron
https://www.readbyqxmd.com/read/24267654/a-unique-population-of-ventral-tegmental-area-neurons-inhibits-the-lateral-habenula-to-promote-reward
#15
Alice M Stamatakis, Joshua H Jennings, Randall L Ung, Grace A Blair, Richard J Weinberg, Rachael L Neve, Frederick Boyce, Joanna Mattis, Charu Ramakrishnan, Karl Deisseroth, Garret D Stuber
Lateral habenula (LHb) neurons convey aversive and negative reward conditions through potent indirect inhibition of ventral tegmental area (VTA) dopaminergic neurons. Although VTA dopaminergic neurons reciprocally project to the LHb, the electrophysiological properties and the behavioral consequences associated with selective manipulations of this circuit are unknown. Here, we identify an inhibitory input to the LHb arising from a unique population of VTA neurons expressing dopaminergic markers. Optogenetic activation of this circuit resulted in no detectable dopamine release in LHb brain slices...
November 20, 2013: Neuron
https://www.readbyqxmd.com/read/23407950/olfactory-bulb-short-axon-cell-release-of-gaba-and-dopamine-produces-a-temporally-biphasic-inhibition-excitation-response-in-external-tufted-cells
#16
Shaolin Liu, Celine Plachez, Zuoyi Shao, Adam Puche, Michael T Shipley
Evidence for coexpression of two or more classic neurotransmitters in neurons has increased, but less is known about cotransmission. Ventral tegmental area (VTA) neurons corelease dopamine (DA), the excitatory transmitter glutamate, and the inhibitory transmitter GABA onto target cells in the striatum. Olfactory bulb (OB) short axon cells (SACs) form interglomerular connections and coexpress markers for DA and GABA. Using an optogenetic approach, we provide evidence that mouse OB SACs release both GABA and DA onto external tufted cells (ETCs) in other glomeruli...
February 13, 2013: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/22840394/selective-activation-of-cholinergic-interneurons-enhances-accumbal-phasic-dopamine-release-setting-the-tone-for-reward-processing
#17
Roger Cachope, Yolanda Mateo, Brian N Mathur, James Irving, Hui-Ling Wang, Marisela Morales, David M Lovinger, Joseph F Cheer
Dopamine plays a critical role in motor control, addiction, and reward-seeking behaviors, and its release dynamics have traditionally been linked to changes in midbrain dopamine neuron activity. Here, we report that selective endogenous cholinergic activation achieved via in vitro optogenetic stimulation of nucleus accumbens, a terminal field of dopaminergic neurons, elicits real-time dopamine release. This mechanism occurs via direct actions on dopamine terminals, does not require changes in neuron firing within the midbrain, and is dependent on glutamatergic receptor activity...
July 26, 2012: Cell Reports
https://www.readbyqxmd.com/read/22593052/dopaminergic-modulation-of-mitral-cells-and-odor-responses-in-the-zebrafish-olfactory-bulb
#18
Sebastian T Bundschuh, Peixin Zhu, Yan-Ping Zhang Schärer, Rainer W Friedrich
In the olfactory bulb, the modulatory neurotransmitter dopamine (DA) is coexpressed with GABA by local interneurons, but its role in odor processing remains obscure. We examined functions of DA mediated by D₂-like receptors in the olfactory bulb of adult zebrafish by pharmacology, whole-cell recordings, calcium imaging, and optogenetics. Bath application of DA had no detectable effect on odorant-evoked sensory input. DA directly hyperpolarized mitral cells (MCs) via D₂-like receptors and slightly increased their response gain...
May 16, 2012: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/22069471/multiple-doublesex-related-genes-specify-critical-cell-fates-in-a-c-elegans-male-neural-circuit
#19
Meagan S Siehr, Pamela K Koo, Amrita L Sherlekar, Xuelin Bian, Meredith R Bunkers, Renee M Miller, Douglas S Portman, Robyn Lints
BACKGROUND: In most animal species, males and females exhibit differences in behavior and morphology that relate to their respective roles in reproduction. DM (Doublesex/MAB-3) domain transcription factors are phylogenetically conserved regulators of sexual development. They are thought to establish sexual traits by sex-specifically modifying the activity of general developmental programs. However, there are few examples where the details of these interactions are known, particularly in the nervous system...
2011: PloS One
https://www.readbyqxmd.com/read/20534006/optogenetic-control-of-striatal-dopamine-release-in-rats
#20
COMPARATIVE STUDY
Caroline E Bass, Valentina P Grinevich, Zachary B Vance, Ryan P Sullivan, Keith D Bonin, Evgeny A Budygin
Optogenetic control over neuronal firing has become an increasingly elegant method to dissect the microcircuitry of mammalian brains. To date, examination of these manipulations on neurotransmitter release has been minimal. Here we present the first in-depth analysis of optogenetic stimulation on dopamine neurotransmission in the dorsal striatum of urethane-anesthetized rats. By combining the tight spatial and temporal resolution of both optogenetics and fast-scan cyclic voltammetry we have determined the parameters necessary to control phasic dopamine release in the dorsal striatum of rats in vivo...
September 1, 2010: Journal of Neurochemistry
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