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mistletoe and cancer

Ruchi Mishra, Mrinal K Das, Savita Singh, Radhey Shyam Sharma, Sadhna Sharma, Vandana Mishra
Leukemia is among the most aggressive and prevalent human malignant carcinoma. Chemotherapy is the preferred therapeutic strategy; however, recurrence of cancer and non-selective cytotoxicity are the major concerns. Unlike synthetic chemotherapeutic agents, mistletoe ribosome-inactivating protein (RIP) displays anti-tumor function in various types of cancers. However, its effect on leukemia cells is little explored. In this study, we assessed the impact of Viscum articulatum RIP (Articulatin-D) on the survival of acute T-cell leukemia cells and the involved molecular and cellular mechanisms...
November 21, 2016: Molecular and Cellular Biochemistry
Nimmy Kumar, Subhankar Biswas, Asha Elizabeth Mathew, Subin Varghese, Jessy Elizabeth Mathew, K Nandakumar, Jesil Mathew Aranjani, Richard Lobo
BACKGROUND: Hepatocellular carcinoma (HCC), the most common type of liver cancer accounts for more than one million deaths worldwide. Current treatment modality for HCC is marginally effective. Plants belonging to Mistletoe family (Loranthaceae) have been used in chemotherapy for many years. The present study was aimed at exploring the anti-proliferative, pro-oxidant and pro-apoptotic potential of stem of Elytranthe parasitica (L.) Danser (EP), a parasitic shrub belonging to Loranthaceae...
October 26, 2016: BMC Complementary and Alternative Medicine
Agustina Tri Endharti, Adisti Wulandari, Anik Listyana, Eviana Norahmawati, Sofy Permana
BACKGROUND: Indonesian mistletoe grows on various trees. Mango Mistletoes (Dendrophthoe pentandra) is one type of mistletoe that grown on mango tree (.benalu mangga in bahasa Indonesia). Our study used mistletoe as a parasitic plant that has been used for traditional medicine. It has been known that Dendrophtoe pentandra extract (DPE) anti-inflammatory and anticancer. Furthermore, it is necessary to follow-up study in vivo to evaluate the response to treatment of new cancer therapeutic agents...
September 26, 2016: BMC Complementary and Alternative Medicine
Monika Twardziok, Susann Kleinsimon, Jana Rolff, Sebastian Jäger, Angelika Eggert, Georg Seifert, Catharina I Delebinski
Ewing sarcoma is the second most common bone cancer in children and adolescents, with poor prognosis and outcome in ~70% of initial diagnoses and 10-15% of relapses. Hydrophobic triterpene acids and hydrophilic lectins and viscotoxins from European mistletoe (Viscum album L.) demonstrate anticancer properties, but have not yet been investigated for Ewing sarcoma. Commercial Viscum album L. extracts are aqueous, excluding the insoluble triterpenes. We recreated a total mistletoe effect by combining an aqueous extract (viscum) and a triterpene extract (TT) solubilized with cyclodextrins...
2016: PloS One
Ya Chee Lim, Rajan Rajabalaya, Shirley Huan Fang Lee, Kushan U Tennakoon, Quang-Vuong Le, Adi Idris, Ihsan N Zulkipli, Natasha Keasberry, Sheba R David
The mistletoes, stem hemiparasites of Asia and Europe, have been used as medicinal herbs for many years and possess sophisticated systems to obtain nutrients from their host plants. Although knowledge about ethnomedicinal uses of mistletoes is prevalent in Asia, systematic scientific study of these plants is still lacking, unlike its European counterparts. This review aims to evaluate the literature on Scurrula and Viscum mistletoes. Both mistletoes were found to have anticancer, antimicrobial, antioxidant and antihypertensive properties...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
U Weissenstein, M Kunz, K Urech, U Regueiro, S Baumgartner
BACKGROUND: Besides conventional anticancer therapy many breast cancer patients use complementary and alternative medicine (CAM) like the medicinal herb mistletoe (Viscum album L.). To gain more knowledge about possible herb-drug interactions between CAM and conventional anticancer medications, in the present in vitro study we investigated the effect of a standardized mistletoe preparation on the action of Trastuzumab, a drug used for the treatment of Her-2 positive breast cancer. METHODS: The Her-2 positive human breast carcinoma cell line SK-BR-3 was treated with Trastuzumab...
2016: BMC Complementary and Alternative Medicine
Mohsen Marvibaigi, Neda Amini, Eko Supriyanto, Fadzilah Adibah Abdul Majid, Saravana Kumar Jaganathan, Shajarahtunnur Jamil, Javad Hamzehalipour Almaki, Rozita Nasiri
Scurrula ferruginea (Jack) Danser is one of the mistletoe species belonging to Loranthaceae family, which grows on the branches of many deciduous trees in tropical countries. This study evaluated the antioxidant activities of S. ferruginea extracts. The cytotoxic activity of the selected extracts, which showed potent antioxidant activities, and high phenolic and flavonoid contents, were investigated in human breast cancer cell line (MDA-MB-231) and non-cancer human skin fibroblast cells (HSF-1184). The activities and characteristics varied depending on the different parts of S...
2016: PloS One
Marc Schläppi, Christoph Ewald, Jürgen Johannes Kuehn, Tomas Weinert, Roman Huber
Purpose So-called spontaneous remissions in cancer often seem to occur after febrile events. Mistletoe preparations (MPs) are used off-label intravenously to induce fever within concepts of integrative oncology. We wanted to investigate the frequency of febrile reactions and safety related to intravenously applied MPs (IAMPs). Methods This was a retrospective analysis of data from consecutive cancer patients who were treated in 2 anthroposophic hospitals with IAMPs. The main outcome parameter was the rate of core temperature increase to ≥38...
July 7, 2016: Integrative Cancer Therapies
Gunver S Kienle, Milena Mussler, Dieter Fuchs, Helmut Kiene
Background. Mistletoe therapy (MT) is widely used in patient-centered integrative cancer care. The objective of this study was to explore the concepts, procedures, and observations of expert doctors, with a focus on intravenous MT. Method. A qualitative interview study was conducted with 35 highly experienced doctors specialized in integrative and anthroposophic medicine. Structured qualitative content analysis was applied. For triangulation, the results were compared with external evidence that was systematically collected, reviewed, and presented...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
Leanna J Standish, Fred Dowd, Erin Sweet, Linda Dale, Morgan Weaver, Barbara Osborne, M Robyn Andersen
BACKGROUND: Naturopathic oncology in conjunction with conventional treatment is commonly referred to as integrative oncology (IO). Clinics directed by oncology board certified NDs (Fellows of the American Board of Naturopathic Oncology or FABNOs) provide high-quality data for describing IO therapies, their costs and measuring clinical outcomes. PURPOSE: To describe the types of IO therapies prescribed to breast cancer patients by ND FABNO physicians. Study participants (n = 324)...
May 26, 2016: Integrative Cancer Therapies
Maurice Orange, Uwe Reuter, Uwe Hobohm
The following four observations point in the same direction, namely that there is an unleveraged potential for stimulating the innate immune system against cancer: (1) experimental treatments with bacterial extracts more than 100 years ago by Coley and contemporaries, (2) a positive correlation between spontaneous regressions and febrile infection, (3) epidemiological data suggesting an inverse correlation between a history of infection and the likelihood of developing cancer, and (4) our recent finding that a cocktail of pattern recognition receptor ligands (PRRLs) can eradicate solid tumors in cancer mice if applied metronomically...
May 20, 2016: Integrative Cancer Therapies
Gunver S Kienle, Milena Mussler, Dieter Fuchs, Helmut Kiene
Background Cancer patients widely seek integrative oncology which embraces a wide variety of treatments and system approaches. Objective To investigate the concepts, therapeutic goals, procedures, and working conditions of integrative oncology doctors in the field of anthroposophic medicine. Methods This qualitative study was based on in-depth interviews with 35 highly experienced doctors working in hospitals and office-based practices in Germany and other countries. Structured qualitative content analysis was applied to examine the data...
May 4, 2016: Integrative Cancer Therapies
Vida Elsyana, Maria Bintang, Bambang Pontjo Priosoeryanto
Clove mistletoe (Dendrophthoe pentandra (L.) Miq.) is a semiparasitic plant that belongs to Loranthaceae family. Clove mistletoe was traditionally used for cancer treatment in Indonesia. In the present study, we examined cytotoxicity of clove mistletoe leaves extracts against brine shrimps and conducted their antiproliferative activity on K562 (human chronic myelogenous leukemia) and MCM-B2 (canine benign mixed mammary) cancer cell lines in vitro. The tested samples were water extract, ethanol extract, ethanol fraction, ethyl acetate fraction, and n-hexane fraction...
2016: Advances in Pharmacological Sciences
Katharina Mulsow, Thomas Enzlein, Catharina Delebinski, Sebastian Jaeger, Georg Seifert, Matthias F Melzig
Complementary treatment possibilities for the therapy of cancer are increasing in demand due to the severe side effects of the standard cytostatics used in the first-line therapy. A common approach as a complementary treatment is the use of aqueous extracts of Viscum album L. (Santalaceace). The therapeutic activity of these extracts is attributed to Mistletoe lectins which are Ribosome-inactivating proteins type II. Besides these main constituents the extract of Viscum album L. comprises also a mixture of lipophilic ingredients like triterpene acids of the oleanane, lupane and ursane type...
2016: PloS One
Se-Yong Kim, Eun-Ju Yang, Youn Kyoung Son, Joo-Hong Yeo, Kyung-Sik Song
Viscum album var. coloratum (Korean mistletoe; KM) is an herbal medicine that is used worldwide for the treatment of various immunological disorders and cancers. KM extract showed enhanced anti-oxidative effects in 2,2-diphenyl-1-picrylhydrazyl, Trolox equivalent antioxidant capacity, and 5-(and-6)-chloromethyl-2',7'-dichlorodihydrofluorescein diacetate acetyl ester assays after being fermented with a crude enzyme extract from a soybean paste fungus, Aspergillus kawachii. High-performance liquid chromatography analysis showed four increased peaks in enzyme treated KM...
May 18, 2016: Food & Function
Suzana Borovic Sunjic, Ana Cipak Gasparovic, Tea Vukovic, Thomas Weiss, Elisabeth Sussman Weiss, Ivo Soldo, Nikola Djakovic, Tomislav Zarkovic, Neven Zarkovic
Within the integrative medicine one of the most frequently used adjuvant cancer biotherapies is based on aqueous mistletoe (Viscum album) extracts. Tumor growth inhibition, stimulation of host immune response and improvement of the quality of life are the positive effects of mistletoe therapy described in several preclinical and clinical studies. However, cumulative results of the evidence based medicine findings on such treatments are rarely given. Therefore, this paper evaluates the evidence based findings describing effects of the Viscum album extract Isorel in cancer therapy with respect to the type of therapy, stage and type of illness...
September 2015: Collegium Antropologicum
Tim Schütze, Alfred Längler, Tycho Jan Zuzak, Pia Schmidt, Boris Zernikow
PURPOSE: Although the popularity of complementary and alternative medicine (CAM) has risen in the last decade, information about its use by pediatric patients in palliative care is still scarce. The purpose of the study was to assess the frequency and types of CAM administered by parents with children suffering from cancer during the palliative phase. METHODS: All parents who lost their child due to cancer in the federal state North Rhine Westfalia/Germany were eligible for the study...
July 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Manuela Monti
This is the time of the precision medicine, as President Barak Obama addressed the Nation on January 20, 2015 in a State of the Union Address: Tonight, I'm launching a new Precision Medicine Initiative to bring us closer to curing diseases like cancer and diabetes - and to give all of us access to the personalized information we need to keep ourselves and our families healthier (Francis S. Collins and Harold Varmus, A New Initiative on Precision Medicine; N Engl J Med 2015;372:793-795). This new field already show several actors, not only the NIH but also private company like APPLE, MICROSOFT and others, investing a lot of many: all together already several billions, dollars or euro doesn't matter, a fact that testify how hot is becoming this new biomedical perspective...
2015: European Journal of Histochemistry: EJH
Tatjana Srdic-Rajic, Nevena Tisma-Miletic, Milena Cavic, Ksenija Kanjer, Katarina Savikin, Danijel Galun, Aleksandra Konic-Ristic, Tamara Zoranovic
Toxicity of conventional chemotherapeutics highlights the requirement for complementary or alternative medicines that would reduce side effects and improve their anticancer effectiveness. European mistletoe (Viscum album) has long been used as a complementary and alternative medicine supporting cancer therapy. The aim of this study was to investigate synergistic antitumor action of V. album extract and doxorubicin during co-treatment of chemoresistant chronic myelogenic leukemia K562 cells. Combined treatment of leukemia cells led to inhibitory synergism at sub-apoptotic doxorubicin concentrations and multifold reduction of cytotoxic effects in healthy control cells...
March 2016: Phytotherapy Research: PTR
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