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https://www.readbyqxmd.com/read/28724883/calcium-prepartions-do-not-inhibit-allergic-reactions-a-randomized-controlled-trial
#1
Klaudia Matysiak, Michał Matuszewski, Wojciech Feleszko
INTRODUCTION    Massive consumption of dietary supplements, including vitamins and minerals, has recently became a serious public issue in Europe. When ingested, they may negatively affect pharmacological activity of various medications, including anti-allergic drugs. Calcium preparations are well-known and commonly used in some European countries as a popular remedy for allergy-related skin reactions, such as itching, erythema and wheals, as well as insect bites. However, their action has not been reliably proven yet...
June 27, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28722633/characterization-of-sarcoptes-scabiei-tropomyosin-and-paramyosin-immunoreactive-allergens-in-scabies
#2
Shumaila Naz, Marion Desclozeaux, Kate E Mounsey, Farhana Riaz Chaudhry, Shelley Walton
Scabies is a human skin disease due to the burrowing ectoparasite Sarcoptes scabiei var. hominis resulting in intense itching and inflammation and manifesting as a skin allergy. Because of insufficient mite material and lack of in vitro propagation system for antigen preparation, scabies is a challenging disease to develop serological diagnostics. For allergen characterization, full-length S. scabiei tropomyosin (Sar s 10) was cloned, expressed in pET-15b, and assessed for reactivity with IgE antibodies from human sera...
July 10, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28719274/risk-factors-for-podoconiosis-kamwenge-district-western-uganda-september-2015
#3
Christine Kihembo, Ben Masiira, William Z Lali, Gabriel K Matwale, Joseph K B Matovu, Frank Kaharuza, Alex R Ario, Immaculate Nabukenya, Issa Makumbi, Monica Musenero, Bao-Ping Zhu, Miriam Nanyunja
AbstractPodoconiosis, a noninfectious elephantiasis, is a disabling neglected tropical disease. In August 2015, an elephantiasis case-cluster was reported in Kamwenge District, western Uganda. We investigated to identify the disease's nature and risk factors. We defined a suspected podoconiosis case as onset in a Kamwenge resident of bilateral asymmetrical lower limb swelling lasting ≥ 1 month, plus ≥ 1 of the following associated symptoms: skin itching, burning sensation, plantar edema, lymph ooze, prominent skin markings, rigid toes, or mossy papillomata...
June 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28712817/clinical-features-and-dynamic-ordinary-laboratory-tests-differentiating-dengue-fever-from-other-febrile-illnesses-in-children
#4
Chih-Ho Chen, Yi-Chuan Huang, Kuang-Che Kuo, Chung-Chen Li
BACKGROUND: Dengue fever is not easily to be diagnosed before presentation of the classic symptoms. The study aimed to investigate the clinical features and dynamic laboratory tests in pediatric patients to facilitate dengue diagnosis. METHODS: This retrospective study examined the medical records of all pediatric patients who were clinically suspected to have dengue from June to December 2014. Laboratory-positive dengue cases were confirmed by detecting non-structural protein NS1, reverse transcription-polymerase chain reaction of dengue virus, and dengue-specific IgM seroconversion...
June 30, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28710680/development-of-a-novel-tool-to-assess-the-impact-of-itching-in-pediatric-cholestasis
#5
Binita M Kamath, Linda Abetz-Webb, Ciara Kennedy, Bonnie Hepburn, Martha Gauthier, Nathan Johnson, Sharon Medendorp, Alejandro Dorenbaum, Lora Todorova, Benjamin L Shneider
OBJECTIVES: The aim was to develop a clinical outcome assessment (COA) for itching in children with cholestatic pruritus. METHODS: This prospective study aimed to enroll patients aged 4-30 years with Alagille syndrome (ALGS) or progressive familial intrahepatic cholestasis type 1 and caregivers of patients aged 5 months to 14 years. Eligible patients experienced itching during ≥3 of the 7 days before enrollment and had not undergone liver transplant or surgical interruption of the enterohepatic circulation...
July 14, 2017: Patient
https://www.readbyqxmd.com/read/28707186/natural-oils-for-skin-barrier-repair-ancient-compounds-now-backed-by-modern-science
#6
REVIEW
Alexandra R Vaughn, Ashley K Clark, Raja K Sivamani, Vivian Y Shi
Natural plant oils are commonly used as topical therapy worldwide. They are usually easily accessible and are relatively inexpensive options for skin care. Many natural oils possess specific compounds with antimicrobial, antioxidant, anti-inflammatory, and anti-itch properties, making them attractive alternative and complementary treatments for xerotic and inflammatory dermatoses associated with skin-barrier disruption. Unique characteristics of various oils are important when considering their use for topical skin care...
July 13, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28705181/the-impact-of-antiretroviral-therapy-on-symptom-burden-among-hiv-outpatients-with-low-cd4-count-in-rural-uganda-nested-longitudinal-cohort-study
#7
Katie Wakeham, Richard Harding, Jonathan Levin, Rosalind Parkes-Ratanshi, Anatoli Kamali, David G Lalloo
BACKGROUND: Individuals with HIV have a high prevalence of physical and psychological symptoms throughout their disease course. Despite the clinical and public health implications of unresolved pain and symptoms, little is known about the effect of anti-retroviral therapy (ART) on these outcomes. This study aimed to assess the impact on symptom burden for the year after ART initiation in individuals with a CD4 count <200 cells/uL in Uganda. METHODS: HIV-infected, ART-naıve adults referred from voluntary testing and counseling services in rural Uganda for enrollment into a randomized controlled trial to test fluconazole as primary prophylaxis against cryptococcal disease were invited to complete the Memorial Symptom Assessment Scale-Short Form (MSAS-SF) prior to commencing ART and at two subsequent follow up visits...
July 13, 2017: BMC Palliative Care
https://www.readbyqxmd.com/read/28701920/tlx3-function-in-the-dorsal-root-ganglion-is-pivotal-to-itch-and-pain-sensations
#8
Chengcheng Huang, Fumin Lu, Ping Li, Cheng Cao, Zijing Liu
Itch, a sensation eliciting a desire to scratch, is distinct from but not completely independent of pain. Inspiring achievements have been made in the characterization of itch-related receptors and neurotransmitters, but the molecular mechanisms controlling the development of pruriceptors remain poorly understood. Here, our RNAseq and in situ hybridization data show that the transcription factor Tlx3 is required for the expression of a majority of itch-related molecules in the dorsal root ganglion (DRG). As a result, Tlx3(F/F);Nav1...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28698763/wolf-s-panniculitis
#9
Anastasiya Atanasova Chokoeva, Georgi Tchernev
A 28-year-old male patient, presented with a one-week history of pain and itching on the skin of the left upper leg. Erythematous indurated, warm and painful on palpation, subcutaneous plaques and nodules were clinically observed, affecting the skin of the left upper leg, within a recent black-wolf tattoo. The diagnosis of traumatic panniculitis with superposed bacterial infection, provoked by a wolf tattoo was made. The patient underwent 7-days systemic antibiotic treatment regimen and topical application of iodine povidone unguent under occlusion for 7 days...
June 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28698528/inflammatory-and-noninflammatory-itch-implications-in-pathophysiology-directed-treatments
#10
REVIEW
Lai-San Wong, Tiffany Wu, Chih-Hung Lee
Itch is the main chief complaint in patients visiting dermatologic clinics and has the ability to deeply impair life quality. Itch results from activation of cutaneous nerve endings by noxious stimuli such as inflammatory mediators, neurotransmitters and neuropeptides, causing itch signal transduction from peripheral skin, through the spinal cord and thalamus, to the brain cortex. Primarily noninflammatory diseases, such as uremic pruritus, cause itch through certain pruritogens in the skin. In inflammatory skin diseases, atopic dermatitis (AD) is the prototypic disease causing intensive itch by aberrant skin inflammation and epidermal barrier disruption...
July 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28697218/a-1-colloidal-oatmeal-cream-alone-is-effective-in-reducing-symptoms-of-mild-to-moderate-atopic-dermatitis-results-from-two-clinical-studies
#11
Toni Anne Lisante, Chris Nunez, Paul Zhang, Barbara M Mathes
<p>BACKGROUND: The epidermal barrier in patients with atopic dermatitis (AD) is deficient in ceramides and cathelicidins. Such epidermal defects may be a trigger for AD, thereby encouraging research toward development of skin-barrier-targeted preventive strategies.</p> <p>METHODS: Two single-center, single-arm clinical trials were conducted (study 1, age greater than equal to 8 years and study 2, greater than equal to 10 years) in patients with mild to moderate AD to evaluate the effects of an over-the-counter 1% colloidal oatmeal cream administered for 14 days...
July 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28695173/identification-of-symptom-clusters-in-cancer-patients-at-palliative-care-clinic
#12
Gülçin Şenel Özalp, Neşe Uysal, Gonca Oğuz, Nesteren Koçak, Şerife Karaca, Nihan Kadıoğulları
OBJECTIVE: Cancer patients often experience a large number of symptoms together. The aim of this study is to determine the symptom clusters in cancer patients at palliative care clinic. METHODS: Hundred and seventy consecutive patients were enrolled in the study. Memorial Symptom Assessment Scale was used for symptom assessment of the patients. RESULTS: The most experienced symptoms by the patients during the past week before hospitalization in palliative care clinic were lack of energy (95...
July 2017: Asia-Pacific Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28686974/phytotherapeutic-potential-of-natural-herbal-medicines-for-the-treatment-of-mild-to-severe-atopic-dermatitis-a-review-of-human-clinical-studies
#13
REVIEW
Zahid Hussain, Hnin Ei Thu, Ahmad Nazrun Shuid, Prashant Kesharwani, Shahzeb Khan, Fahad Hussain
For many decades, natural herbal medicines, polyherbal formulations and/or decoctions of plant-derived materials have widely been accepted as alternative complementary therapies for the treatment, cure or prevention of a wide range of acute and chronic skin diseases including chronic herpes, prurigo, acute and chronic wounds, psoriasis and atopic dermatitis (AD). This review was aimed to summarize and critically discuss about the therapeutic viability and clinical applicability of natural herbal medicines for the treatment of AD in human...
July 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28685545/decreased-plasma-kallikrein-5-concentrations-in-patients-with-chronic-spontaneous-urticaria
#14
A Grzanka, A Damasiewicz-Bodzek, M Szumska, A Kasperska-Zajac
Little is known about the role of the kallikrein-kinin system in chronic spontaneous urticaria (CSU). Kallikrein 5 (KLK5), a trypsin-like enzyme, is the most abundant in the skin and plays a role in itching and inflammatory reaction. In this study, we determined plasma KLK5 concentration, and its associations with acute phase response in CSU patients. Concentrations of KLK5 in plasma and CRP in serum were measured in patients with CSU of varying severity and in the healthy subjects. Plasma KLK5 concentrations were significantly lower in CSU (all) and moderate-severe CSU patients, as compared with the controls...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28681640/disgusting-clusters-trypophobia-as-an-overgeneralised-disease-avoidance-response
#15
Tom R Kupfer, An T D Le
Individuals with trypophobia have an aversion towards clusters of roughly circular shapes, such as those on a sponge or the bubbles on a cup of coffee. It is unclear why the condition exists, given the harmless nature of typical eliciting stimuli. We suggest that aversion to clusters is an evolutionarily prepared response towards a class of stimuli that resemble cues to the presence of parasites and infectious disease. Trypophobia may be an exaggerated and overgeneralised version of this normally adaptive response...
July 6, 2017: Cognition & Emotion
https://www.readbyqxmd.com/read/28670717/emerging-role-of-interleukin-31-and-interleukin-31-receptor-in-pruritus-in-atopic-dermatitis
#16
REVIEW
Masutaka Furue, Kazuhiko Yamamura, Makiko Kido-Nakahara, Takeshi Nakahara, Yoshinori Fukui
Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder associated with skin barrier dysfunction. The lesional skin of AD exhibits T helper 2 (TH 2)-deviated immune reactions. Interleukin-31 (IL-31), preferentially produced from TH 2 cells, is a potent pruritogenic cytokine, and its systemic and local administration induces scratching behavior in rodents, dogs and monkeys. Recent clinical trials have revealed that administration of an anti-IL-31 receptor antibody significantly alleviates pruritus in patients with AD...
July 3, 2017: Allergy
https://www.readbyqxmd.com/read/28668109/seasonal-variation-and-monthly-patterns-of-skin-symptoms-in-korean-children-with-atopic-eczema-dermatitis-syndrome
#17
Minji Kim, Young-Min Kim, Ji Young Lee, Hea-Kyoung Yang, Hyunmi Kim, Joongbum Cho, Kangmo Ahn, Jihyun Kim
BACKGROUND: There have been controversies about the seasonality in aggravation of atopic eczema/dermatitis syndrome (AEDS) symptoms, although understanding the seasonal patterns of AEDS symptoms is an important step in preventing exacerbation through proactive management. OBJECTIVE: The aim of this study was to evaluate whether there are seasonal variations or monthly patterns of symptoms in children with AEDS. METHODS: A total of 590 children with AEDS (median age, 21 months) were enrolled and were followed up for at least 1 year between August 2012 and March 2015...
July 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28665811/small-fibre-neuropathy
#18
Daniele Cazzato, Giuseppe Lauria
PURPOSE OF REVIEW: To provide a review on the state-of-art of clinical features, diagnostics, genetics and treatments of small fibre neuropathy (SFN). RECENT FINDINGS: The spectrum of clinical features has been widened from the classical presentation of burning feet as length-dependent SFN to that of small fibre dysfunction and/or degeneration associated with focal, diffuse and episodic neuropathic pain syndromes. The involvement of small nerve fibres in neurodegenerative diseases has been further defined, challenging the relationship between neuropathic pain symptoms and small fibre loss...
June 29, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28662006/-turmeric-not-only-spice
#19
EDITORIAL
Zygmunt Zdrojewicz, Marta Szyca, Ewa Popowicz, Tomasz Michalik, Bartłomiej Śmieszniak
The purpose of this article is to introduce the role of turmeric in medicine and summarize the current state of research on its applications. Turmeric (Curcuma longa) has had a wide range of uses in middle eastern and orietnal traditional medicine. Currently, however, its use has been truncated to a common cooking spice, despite numerous studies pointing to its healing properties and possible use in the treatment of many diseases. The main focus is on curcumin, a polyphenol which serves as the biologically active component of turmeric...
June 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28653403/dermatitis-caused-by-arthropods-in-domestic-environment-an-italian-multicentre-study
#20
L Stingeni, L Bianchi, K Hansel, D Neve, C Foti, M Corazza, V Bini, I Moretta, M Principato
BACKGROUND: Skin diseases caused by mites and insects living in domestic environments have been rarely systematically studied. OBJECTIVES: To study patients with dermatitis induced by arthropods in domestic environment describing their clinical features, isolating culprit arthropods and relating the clinical features to the parasitological data. METHODS: The study was performed in 105 subjects with clinical and anamnestic data compatible with the differential diagnosis of ectoparasitoses in domestic environments...
June 27, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
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