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https://www.readbyqxmd.com/read/28078772/skin-cleansing-and-emolliating-for-older-people-a-quasi-experimental-pilot-study
#1
Jill Brooks, Fiona Cowdell, Steven J Ersser, Eric D Gardiner
AIMS: The aims of this study were to (i) assess the effect of low-cost hygiene and emollient regimens on the skin barrier function (SBF) of people aged >65 year with xerosis (dry skin) on their lower legs; (ii) to assess the utility of portable measures of skin barrier function in terms of stratum corneum hydration (SCH) and transepidermal water loss (TEWL) in community settings; and iii) to provide evidence for a randomised controlled trial on the treatment of adults in a resource-poor country with dry skin on their lower legs which causes and exacerbates the skin disease podoconiosis (non-filarial elephantiasis)...
January 12, 2017: International Journal of Older People Nursing
https://www.readbyqxmd.com/read/28073787/col6a5-variants-in-familial-neuropathic-chronic-itch
#2
Filippo Martinelli-Boneschi, Marina Colombi, Marco Castori, Grazia Devigili, Roberto Eleopra, Rayaz A Malik, Marco Ritelli, Nicoletta Zoppi, Chiara Dordoni, Melissa Sorosina, Paola Grammatico, Hassan Fadavi, Monique M Gerrits, Rowida Almomani, Catharina G Faber, Ingemar S J Merkies, Daniela Toniolo, Massimiliano Cocca, Claudio Doglioni, Stephen G Waxman, Sulayman D Dib-Hajj, Michela M Taiana, Jenny Sassone, Raffaella Lombardi, Daniele Cazzato, Andrea Zauli, Silvia Santoro, Margherita Marchi, Giuseppe Lauria
Itch is thought to represent the peculiar response to stimuli conveyed by somatosensory pathways shared with pain through the activation of specific neurons and receptors. It can occur in association with dermatological, systemic and neurological diseases, or be the side effect of certain drugs. However, some patients suffer from chronic idiopathic itch that is frequently ascribed to psychological distress and for which no biomarker is available to date. We investigated three multigenerational families, one of which diagnosed with joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type (JHS/EDS-HT), characterized by idiopathic chronic itch with predominantly proximal distribution...
January 9, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28069324/differences-in-therapeutic-effects-of-topically-applied-corticosteroid-and-tacrolimus-on-atopic-dermatitis-like-symptoms-in-nc-nga-mice
#3
Atsushi Noguchi, Mitsutoshi Tominaga, Nobuaki Takahashi, Hironori Matsuda, Yayoi Kamata, Yoshie Umehara, Kyi Chan Ko, Yasushi Suga, Hideoki Ogawa, Kenji Takamori
BACKGROUND: Topical corticosteroid and calcineurin inhibitor have similar therapeutic benefits in atopic dermatitis (AD), but the differences in therapeutic mechanisms of action of these agents against AD symptoms are not fully understood. OBJECTIVE: This study was performed to examine the different effects of topical betamethasone valerate (BMV), clobetasol propionate (CBP), and tacrolimus (TAC) on itch-related behavior and dermatitis in NC/Nga mice with AD-like symptoms...
December 24, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28069297/lesions-on-the-back-of-hands-and-female-gender-predispose-to-stigmatization-in-patients-with-psoriasis
#4
Marlena Hawro, Marcus Maurer, Karsten Weller, Romuald Maleszka, Anna Zalewska-Janowska, Andrzej Kaszuba, Zofia Gerlicz-Kowalczuk, Tomasz Hawro
BACKGROUND: Psoriasis vulgaris is characterized by disfiguring and stigmatizing skin lesions. The links among lesions distribution, severity, and stigmatization remain unclear. OBJECTIVE: We sought to investigate if the involvement of visible and sensitive areas is linked to stigmatization. METHODS: In all, 115 patients with psoriasis vulgaris were assessed for disease severity, skin lesions distribution, itch, and stigmatization using the Feelings of Stigmatization Questionnaire...
January 6, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28062820/epidemiology-diagnosis-and-treatment-of-scabies-in-a-dermatology-office
#5
Kathryn L Anderson, Lindsay C Strowd
BACKGROUND: Scabies is a neglected skin disease, and little is known about current incidence and treatment patterns in the United States. The purpose of this study was to examine demographic data, treatment types, success of treatment, and misdiagnosis rate of scabies in an outpatient dermatology clinic. METHODS: A retrospective chart review of patients diagnosed with scabies within the past 5 years was performed. RESULTS: A total of 459 charts were identified, with 428 meeting inclusion criteria...
January 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28057434/atopic-dermatitis-immune-deviation-barrier-dysfunction-ige-autoreactivity-and-new-therapies
#6
REVIEW
Masutaka Furue, Takahito Chiba, Gaku Tsuji, Dugarmaa Ulzii, Makiko Kido-Nakahara, Takeshi Nakahara, Takafumi Kadono
Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder mostly associated with IgE elevation and skin barrier dysfunction due to decreased filaggrin expression. The lesional skin of AD exhibits Th2- and Th22-deviated immune reactions that are progressive during disease chronicity. Th2 and Th22 cytokines further deteriorate the skin barrier by inhibiting filaggrin expression. Some IgEs are reactive to self-antigens. The IgE autoreactivity may precipitate the chronicity of AD...
January 2, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28057164/role-of-pregabalin-in-management-of-pruritus-a-literature-review
#7
Nazanin Foroutan, Naemeh Nikvarz
Pruritus can be one of the distressing symptoms of many dermatologic, systemic, neurologic or psychiatric disorders. In each case, the origin of itch is in the skin and/or the nervous system. Involvement of the nervous system causes neurogenic, psychogenic or neuropathic itch. Itch sensation is transferred to the central nervous system via unmyelinated C-type nerve fibers, and many mediators and receptors engage in the its induction and transmission. Also it has been demonstrated that there are similarities and interactions between neurotransmitters and pathways of pain and itch sensation...
October 2016: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28056209/fractional-co2-laser-from-skin-rejuvenation-to-vulvo-vaginal-reshaping
#8
Maurizio Filippini, Ester Del Duca, Francesca Negosanti, Diletta Bonciani, Luca Negosanti, Mario Sannino, Giovanni Cannarozzo, Steven Paul Nisticò
BACKGROUND: The CO2 laser has become the gold standard treatment in dermatologic surgery for the treatment of a large number of skin and mucosal lesions. The introduction of the fractional micro-ablative technology represented an integration to the ablative resurfacing technique, reducing the healing time and the side effects. OBJECTIVE: Vaginal rejuvenation performed with this technique is a minimally invasive procedure that stimulates internal tissues of the female lower genital tract to regenerate the mucosa, improving tissue trophism and restoring the correct functionality...
December 30, 2016: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28029781/aryl-hydrocarbon-receptor-activation-contributes-to-benzanthrone-induced-hyperpigmentation-via-modulation-of-melanogenic-signaling-pathways
#9
Sabiya Abbas, Shamshad Alam, Krishna P Singh, Mahadeo Kumar, Shailendra K Gupta, Kausar M Ansari
Benzanthrone (BA), an oxidized polycyclic aromatic hydrocarbon (PAH), has been found to be a potential health threat to occupational workers involved in dye manufacturing factories. It has been observed that occupational workers become exposed to BA either during manufacturing, pulverization, or storage and developed various kinds of skin diseases like contact dermatitis, itching, erythema, roughness, and foremost, hyperpigmentation. It has been shown that some environmental organic pollutants (POPs) like dioxins, furans, and polychlorinated biphenyls (PCBs) may act as ligands for the aryl hydrocarbon receptor (AhR) and regulate hyperpigmentation...
January 12, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28018862/delta-hemolysin-and-phenol-soluble-modulins-but-not-alpha-hemolysin-or-panton-valentine-leukocidin-induce-mast-cell-activation
#10
Elisabeth Hodille, Charlotte Cuerq, Cédric Badiou, Françoise Bienvenu, Jean-Paul Steghens, Régine Cartier, Michèle Bes, Anne Tristan, Adriana Plesa, Vien T M Le, Binh A Diep, Gérard Lina, Oana Dumitrescu
Mast cells are located at host interfaces, such as the skin, and contribute to the first-line defense against pathogens by releasing soluble mediators, including those that induce itching and scratching behavior. Here, we show that delta-hemolysin (Hld) and phenol soluble modulins (PSMs) PSMα1 and PSMα3, but not alpha-hemolysin (Hla) or Panton-Valentine leukocidin (PVL), induce dose-dependent tryptase, and lactate dehydrogenase (LDH) release by the HMC-1 human mast cell line. Using supernatants from isogenic strains, we verified that tryptase and LDH release was Hld- and PSMα-dependent...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28012781/the-molecular-and-cellular-mechanisms-of-itch-and-the-involvement-of%C3%A2-trp-channels-in-the-peripheral-sensory-nervous-system-and-skin
#11
REVIEW
Hiroki Kittaka, Makoto Tominaga
Itch is an unpleasant cutaneous sensation that can arise following insect bites, exposure to plant ingredients, and some diseases. Itch can also have idiopathic causes. Itch sensations are thought to protect against external insults and toxic substances. Although itch is not directly lethal, chronic and long lasting itch in certain diseases can worsen quality of life. Therefore, the mechanisms responsible for chronic itch require careful investigation. There is a significant amount of basic research concerning itch, and the effect of various itch mediators on primary sensory neurons have been studied...
December 21, 2016: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/27993143/marginal-zone-lymphoma-derived-interfollicular-diffuse-large-b-cell-lymphoma-harboring-20q12-chromosomal-deletion-and-missense-mutation-of-birc3-gene-a-case-report
#12
Joseph Hatem, April M Schrank-Hacker, Christopher D Watt, Jennifer J D Morrissette, Adam I Rubin, Ellen J Kim, Sunita D Nasta, Mariusz A Wasik, Agata M Bogusz
BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) typically leads to effacement of the nodal architecture by an infiltrate of malignant cells. Rarely (<1%), DLBCL can present with an interfollicular pattern (DLBCL-IF) preserving the lymphoid follicles. It has been postulated that DLBCL-IF is derived from marginal zone B cells and may represent a large-cell transformation of marginal zone lymphoma (MZL), however no direct evidence has been provided to date. Here we describe a rare case of a diagnostically challenging DLBCL-IF involving a lymph node in a patient with a prior history of lymphadenopathy for several years and MZL involving skin...
December 19, 2016: Diagnostic Pathology
https://www.readbyqxmd.com/read/27992712/usefulness-of-allerkin-house-dust-mite-extract-for-nasal-provocation-testing
#13
Kyu-Sung Kim, Tae Young Jang, Young Hyo Kim
Objectives: We evaluated the clinical usefulness of Allerkin (Lofarma) for nasal provocation testing (NPT) in patients with rhinitis symptoms, by examining changes in nasal symptoms and acoustic parameters after exposure to house dust mite (HDM) extract. Methods: Twenty patients (16 males and 4 females, mean age: 29.6±14.6 years) were enrolled. We performed skin prick test (SPT) before and 15 and 30 minutes after intranasal challenge with Allerkin HDM extract, and we evaluated symptom changes (nasal obstruction, rhinorrhea, sneezing, and itching) using a visual analogue scale...
December 20, 2016: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/27983625/trp-channels-in-skin-biology-and-pathophysiology
#14
REVIEW
Michael J Caterina, Zixuan Pang
Ion channels of the Transient Receptor Potential (TRP) family mediate the influx of monovalent and/or divalent cations into cells in response to a host of chemical or physical stimuli. In the skin, TRP channels are expressed in many cell types, including keratinocytes, sensory neurons, melanocytes, and immune/inflammatory cells. Within these diverse cell types, TRP channels participate in physiological processes ranging from sensation to skin homeostasis. In addition, there is a growing body of evidence implicating abnormal TRP channel function, as a product of excessive or deficient channel activity, in pathological skin conditions such as chronic pain and itch, dermatitis, vitiligo, alopecia, wound healing, skin carcinogenesis, and skin barrier compromise...
December 14, 2016: Pharmaceuticals
https://www.readbyqxmd.com/read/27981385/-preclinical-safety-evaluation-of-chloral-hydrate-after-topical-application%C3%A2-using-the-example-of-psoriatic-itch
#15
J Wohlrab, F Gilbrich, L Wolff, M Fischer, S Philipp
BACKGROUND: Psoriasis is known today as a T‑cell-mediated autoimmunological systemic disease. The chronic inflammatory processes involve neuroimmunological factors that are held responsible not only for various aspects of psychiatric-neurological comorbidities but also for neurosensory problems, primarily itching. Amongst other things, the significance of GABAA receptors are often discussed in this context. The topical use of chloral hydrate in semisolid preparations for antipruritic therapy goes back to Neisser and is currently experiencing a revival in individually manufactured formulations...
December 15, 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27974144/the-treatment-of-scabies
#16
Corinna Dressler, Stefanie Rosumeck, Cord Sunderkötter, Ricardo Niklas Werner, Alexander Nast
BACKGROUND: Scabies is a contagious infestation transmitted by skin-to-skin contact and sometimes by contact with contaminated material. The scabies mite burrows into the skin, producing a papular rash and severe itch at typical sites of predilection. METHODS: We systematically reviewed the literature to compare the efficacy of various anti-scabies agents, including a calculation of relative risks and confidence intervals. RESULTS: A literature search yielded 596 initial hits; after screening in accor-dance with the defined inclusion and exclusion criteria, 16 studies were selected for this review...
November 14, 2016: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/27958613/opioid-receptors-in-psoriatic-skin-relationship-with-itch
#17
Piotr Kupczyk, Adam Reich, Marcin Hołysz, Mariusz Gajda, Edyta Wysokińska, Anna Kobuszewska, Dmitry Nevozhay, Beata Nowakowska, Leon Strzadała, Paweł Jagodziński, Jacek C Szepietowski
Psoriasis is an inflammatory immunogenetic skin disease, often accompanied by itch. Opioid receptors are known regulators of itch sensation in the central nervous system. In the brain, μ-opioid receptors may potentiate itch, while activation of κ-opioid receptors may reduce or even alleviate itch; however, the role of opioid receptors in itch perception in the skin is poorly understood. To further elucidate the role of opioid receptors in the neurobiology of psoriatic itch, punch biopsies of non-lesional and lesional skin of patients with psoriasis and healthy controls were studied...
December 13, 2016: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/27941571/clinical-and-histopathological-features-of-post-burn-pruritus
#18
In Suk Kwak, Sook Young Park, Young Hee Choi, Soo Ick Cho, Yoon Seok Yang, Yong Se Cho, Min Gyu Choi, Cheong Hoon Seo, Chun Wook Park, Hye One Kim
The aim of the study was to evaluate the clinical and histopathological characteristics of patients with post burn pruritus. The authors took skin samples from 62 burn patients with or without pruritus. The measured skin condition includes thickness and paresthesia. Various clinical features were rated on patient assessment scale (PSAS) and observer scar assessment scale. The samples were stained with hematoxylin & eosin, Masson's trichrome, Verhoeff's elastic, and toluidine blue stain. The stained samples were analyzed in terms of epidermal thickness, mononuclear cell infiltration, collagen bundles, elastic fibers, and mast cell distribution...
November 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27939458/evidence-for-physiological-and-pathological-roles-for-sensory-nerves-in-the-microvasculature-and-skin
#19
X Kodji, A A Aubdool, S D Brain
This review highlights the progress from the initial finding of neurogenic inflammation up to the most recent development in the field of sensory nerves research, focusing on their roles in the microvasculature and the skin. Recent discovery of Transient Receptor Potential (TRP) channels highlight their important roles in detecting a range of environmental stimuli, including chemical and temperature. This provides us novel mechanisms for driving neurogenic inflammation upstream of neuropeptide release in addition to promising potential therapeutic targets in various diseases, including pain, itching and skin inflammation...
October 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27928524/review-of-medicinal-remedies-on-hand-eczema-based-on-iranian-traditional-medicine-a-narrative-review-article
#20
REVIEW
Parvin Mansouri, Aleme Khademi, Daryoush Pahlevan, Zahra Memariani, Jale Aliasl, Laila Shirbeigii
BACKGROUND: Hand Eczema (HE) is a dermatological disorder with frequent relapses and multiple causes such as atopic, allergic and irritant contact dermatitis. The management is complex because of the wide range of different pathogenesis. Efficacy of some of available treatments is not well established and it can affect patients' quality of life significantly. METHODS: Reports on HE such as diagnosis, pathophysiology, pharmacological and nonpharmacological therapy that described in medieval Iranian medicine, were gathered and analyzed from selected medical and pharmaceutical textbooks of Iranian Traditional Medicine (ITM)...
August 2016: Iranian Journal of Public Health
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