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https://www.readbyqxmd.com/read/29445852/-patient-education-for-adults-with-atopic-dermatitis-according-to-the-arne-concept
#1
REVIEW
A Heratizadeh, T Werfel, U Gieler, J Kupfer
Atopic dermatitis (AD) represents a chronic inflammatory skin disease showing a 1-year prevalence of 2-3% during adulthood. In a national randomized, controlled multicenter study initiated by the "Arbeitsgemeinschaft Neurodermitisschulung im Erwachsenenalter" (ARNE, Working Group on Educational Training for Adults with Atopic Dermatitis) a program for structured patient education conducted by a multiprofessional team was developed and evaluated. At 1‑year follow-up, coping behavior with respect to itch (assessed by the "Juckreiz-Kognitions-Fragebogen", p < 0...
February 14, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29434688/nalbuphine-for-analgesia-after-fracture-surgery-and-its-effect-on-circulating-inflammatory-factors
#2
Yong Gong, Yang Zhang, Shoujun Tao
The present study evaluated the use of nalbuphine for analgesia after fraction reduction surgery. Eighty lower limb fracture patients needing open reduction and internal fixation were selected in the First People's Hospital of Jingzhou from January 2015 to December 2015. Patients were randomly divided into observation and control groups (with 40 cases in each). After surgery, the patients in the observation group were treated with nalbuphine (2 mg/kg) for patient-controlled intravenous analgesia (PCIA), while sufentanil (2...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29432788/different-perception-levels-of-histamine-induced-itch-sensation-in-young-adult-mice
#3
Yeounjung Ji, Yongwoo Jang, Wook Joo Lee, Young Duk Yang, Won-Sik Shim
Itch is an unpleasant sensation that evokes behavioral responses such as scratching the skin. Interestingly, it is conceived that the perception of itch sensation is influenced by age. Indeed, accumulating evidence supports the idea that even children or younger adults show distinctive itch sensation depending on age. This evidence implies the presence of a mechanism that regulates the perception of itch sensation in an age-dependent fashion. Therefore, the purpose of the present study was to investigate a putative mechanism for the age-dependent perception of itch sensation by comparing histamine-induced scratching behaviors in 45-day old (D45) and 75-day old male "young adult" mice...
February 9, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29431207/role-of-mast-cells-and-basophils-in-pruritus
#4
REVIEW
Martin Steinhoff, Jörg Buddenkotte, Ethan A Lerner
To protect our body systems, there is a constant interactive conversation between the skin nervous and immune system. Important elements of this conversation in the skin include mast cells, basophils, and sensory nerve fibers. These cells employ a vast array of sensors that detect danger and react accordingly. This reaction, summarized as neurogenic inflammation, manifests at the conscious level as sensations including pain and itch. Here we provide a perspective on the blossoming knowledge that is illuminating connections between mast cells, basophils, and sensory nerve fibers in the mediation of itch...
March 2018: Immunological Reviews
https://www.readbyqxmd.com/read/29427643/new-mechanism-underlying-il-31-induced-atopic-dermatitis
#5
Jianghui Meng, Masaki Moriyama, Micha Feld, Joerg Buddenkotte, Timo Buhl, Attila Szöllösi, Jingming Zhang, Paul Miller, Andre Ghetti, Michael Fischer, Peter W Reeh, Chunxu Shan, Jiafu Wang, Martin Steinhoff
BACKGROUND: T helper type 2 cell-released interleukin 31 (IL-31) is a critical mediator in atopic dermatitis (AD), a prevalent and debilitating chronic skin disorder. Brain-derived natriuretic peptide (BNP) has been described as a central itch mediator. The importance of BNP in peripheral (skin-derived) itch and its functional link to IL-31 within the neuro-immune axis of the skin is unknown. OBJECTIVE: To investigate the function of BNP in the peripheral sensory system and skin in IL-31-induced itch and neuro-epidermal communication in AD...
February 7, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29427475/application-of-an-8-capsaicin-patch-normalizes-epidermal-trpv1-expression-but-not-the-decreased-intraepidermal-nerve-fibre-density-in-patients-with-brachioradial-pruritus
#6
M P Pereira, H Lüling, A Dieckhöfer, S Steinke, C Zeidler, K Agelopoulos, S Ständer
BACKGROUND: Topical capsaicin shows efficacy in the treatment of brachioradial pruritus, however its mechanisms of action remain unclear. OBJECTIVE: The effect of capsaicin on the epidermis (i.e. peripheral expression of non-neuronal sensory receptors on keratinocytes, morphological changes in innervation) is still unknown. We aimed to investigate the effect of topical capsaicin on keratinocyte expression of TRP channels and on the intraepidermal nerve fibre density (IENFD) in patients with brachioradial pruritus...
February 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29419907/granulomatous-tattoo-reaction-with-associated-uveitis-successfully-treated-with-methotrexate
#7
K I Maijer, S A S van der Bent, W Vercoutere, T Rustemeyer
Few reports describe tattoo granulomas with the simultaneous development of intraocular inflammation without any evidence of systemic sarcoidosis at the time of presentation. Here, we present a patient with no prior diagnosis of sarcoidosis who developed inflammation of tattooed skin and shortly after bilateral uveitis.A 52-year-old previously healthy woman presented with a 8 months history of swelling and itching located in all of her 11 black tattoos. Approximately 5 months later she developed complaints of blurred vision, diagnosed as recurrent uveitis anterior by an ophthalmologist...
February 8, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29406574/uvb-and-ngf-induced-cutaneous-sensitization-in-humans-selectively-augment-cowhage-and-histamine-induced-pain-and-mechanical-hyperknesis
#8
Hjalte H Andersen, Silvia Lo Vecchio, Jesper Elberling, Gil Yosipovitch, Lars Arendt-Nielsen
Exaggerated itch responses to pruritic chemical provocations and mechanical stimuli are evident in patients with chronic itch, e.g., in atopic dermatitis. Currently used human models of itch do not account for such itch sensitization features and the mechanisms underlying clinical itch sensitization are unknown. This study utilized two established human models of cutaneous nociceptive sensitization to explore how pre-established inflammatory hyperalgesia (ultraviolet-B-irradiation; 'UVB') and non-inflammatory neurotrophic pain sensitization (nerve growth factor; 'NGF') alter sensitivity to chemical and mechanically-evoked itch...
February 6, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29406482/randomized-double-blinded-sham-controlled-split-hand-trial-evaluating-the-safety-and-efficacy-of-triamcinolone-acetate-injection-after-calcium-hydroxylapatite-volume-restoration-of-the-dorsal-hand
#9
Douglas C Wu, Mitchel P Goldman
BACKGROUND: Calcium hydroxylapatite (CaHA) is currently the only FDA-approved soft-tissue filler indicated for augmentation of the dorsal hand. Although the treatment is generally safe and effective, adverse side effects such as swelling and edema postinjection are common and can sometimes be debilitating. OBJECTIVE: In this study, the authors explore the utility of triamcinolone acetate coinjection with CaHA to the dorsal hands to mitigate adverse effects and improve patient experience...
February 5, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29406291/why-do-wounds-itch
#10
Ethan Lerner
Everyone has experienced itch. It might simply be the nuisance of a mosquito bite or a transient itch on the scalp that is relieved by a simple scratch. For wounds such as venous ulcers, itch may be present but is usually mild. For some of the 40% of people with neuropathic itch or pain that can develop and persist following mastectomy, itch can be overwhelming, intractable, not widely appreciated by the medical community, and poorly responsive to current treatment regimens. Why are some wounds in some patients itchy whereas seemingly equivalent ones in the same or other patients not? Why is the sensation of itch present in the wound itself in some cases while in the surrounding skin in others? Why are burns so frequently associated with itch? How commonly do wounds itch? Detailed answers to these questions are lacking, but this area is beginning to be explored...
January 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29404508/sofosbuvir-induced-steven-johnson-syndrome-in-a-patient-with-hepatitis-c-virus-related-cirrhosis
#11
Nipun Verma, Shreya Singh, Gitesh Sawatkar, Virendra Singh
Sofosbuvir is an imperative drug used in treatment regimens for hepatitis C virus (HCV). It is considered relatively safe with fewer adverse effects than other treatments. Here, we report a rare and potentially serious, dermatologic, adverse effect following the use of sofosbuvir. A 35-year-old man with genotype 3-related HCV cirrhosis presented with decompensated ascites and jaundice following 7 weeks of therapy with peginterferon alpha-2a and oral ribavirin. After peginterferon withdrawal and stabilization, oral sofosbuvir and ribavirin were started; 10 days later, he developed itching over the trunk and legs, followed by multiple papules and vesicles over an erythematous base...
January 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29402411/epigallocatechin-3-gallate-attenuates-acute-and-chronic-psoriatic-itch-in-mice-involvement-of-antioxidant-anti-inflammatory-effects-and-suppression-of-erk-and-akt-signaling-pathways
#12
Ran Guo, Feng-Ming Zhou, Cun-Jin Su, Teng-Teng Liu, Yan Zhou, Li Fan, Zhi-Hong Wang, Xu Liu, Ya Huang, Tong Liu, Jianping Yang, Li-Hua Chen
Chronic itch is a distressing symptom of many skin diseases and negatively impacts quality of life. However, there is no medication for most forms of chronic itch, although antihistamines are often used for anti-itch treatment. Epigallocatechin-3-gallate (EGCG), a major green tea polyphenol, exhibits anti-oxidative and anti-inflammatory properties. Our previous studies highlighted a key role of oxidative stress and proinflammatory cytokines in acute and chronic itch. Here, we evaluated the effects of green tea polyphenon 60 and EGCG on acute and chronic itch in mouse models and explored its potential mechanisms...
February 1, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29396640/-neurophysiology-of-atopic-pruritus
#13
REVIEW
N H Meyer, B Gibbs, M Schmelz, B Homey, U Raap
Pruritus is one of the major symptoms of inflammatory skin diseases and strongly affects the quality of life in patients. Although the perception of pruritus and pain are closely intertwined, pruritus represents a distinct sensation, which is also significantly different to pain at a neurophysiological level. The pathophysiological basis of chronic and acute pruritus is not fully understood. Besides histamine, a plethora of different neuromediators of itch, including neurotrophins, neuropeptides and their corresponding receptors, have been identified...
February 2, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29394218/alternative-urinary-management-with-an-external-female-collection-device
#14
Terrie Beeson, Carmen Davis
BACKGROUND: Strategies to decrease use of female indwelling urinary catheters and catheter-associated urinary tract infections are challenging due to the limited availability of proper fitting external collection devices. Female urinary incontinence predisposes the skin to potential pain, itching, burning, infection, or pressure injuries. CASE STUDIES: This article discusses 3 patients' trajectory of care with use of an external female urinary collection device...
February 1, 2018: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/29390534/toe-keloid-after-nail-extraction-treated-with-surgical-excision-a-case-report
#15
Hao Liu, Kexin Song, Mingzi Zhang, Xinhang Dong, Shu Liu, Youbin Wang
RATIONALE: In this study, a case of toe keloid after nail extraction is presented, in which the keloids on both toes were resected by surgical excision. Keloids (from the Greek word meaning "crab's claw") are fibrous growths that extend beyond the original area of injury to involve the adjacent normal skin. In general, keloid tendencies appear to be regionally isolated to keloid-prone areas, such as the chest, ears, and deltoid regions, whereas the hands and feet are usually spared, which is why this case is meaningful...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29390311/systemic-contact-dermatitis-due-to-corrosion-of-titanium-coated-nickel-and-cobalt-bone-plate-fixation-a-case-report
#16
Oki Suwarsa, Rachel Marsella Rahardjo, Endang Sutedja, Hartati Purbo Dharmadji, Reti Hindritiani, Hendra Gunawan
RATIONALE: Corrosion refers to the degradation of a material that occurs following its interaction with other substances in the environment. Corrosion of metallic substances into tissues may lead to inflammatory responses such as systemic contact dermatitis (SCD), a skin condition where an individual who has previously been sensitized to a particular allergen via the cutaneous route will subsequently react to same allergen via the systemic route. This condition occurs following exposure to allergens such as metals, medications, and certain food substances...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29387518/effect-of-administrating-polysaccharide-from-black-currant-ribes-nigrum-l-on-atopic-dermatitis-in-nc-nga-mice
#17
Hiroshi Ashigai, Yuta Komano, Guanying Wang, Yasuji Kawachi, Kazuko Sunaga, Reiko Yamamoto, Ryoji Takata, Mika Miyake, Takaaki Yanai
Atopic dermatitis (AD) is a chronic inflammatory skin disease that causes dry skin and functional disruption of the skin barrier. AD is often accompanied by allergic inflammation. AD patient suffer from heavy itching, and their quality of life is severely affected. Some pharmaceuticals for AD have some side effects such as skin atrophy. So it is necessary to develop mild solutions such as food ingredients without side effects. There are various causes of AD. It is especially induced by immunological imbalances such as IFN-γ reduction...
2018: Bioscience of Microbiota, Food and Health
https://www.readbyqxmd.com/read/29386836/asymptomatic-hyperpigmentation-without-preceding-inflammation-as-a-clinical-feature-of-citrus-fruits-induced-phytophotodermatitis
#18
Ji Young Choi, Shinwon Hwang, Si-Hyung Lee, Sang Ho Oh
Phytophotodermatitis is a condition that occurs by contact with plants containing phototoxic agents such as furocoumarins and psoralens with subsequent ultraviolet exposure. Phytophotodermatitis typically presents as sharply defined erythematous patches with occasional blistering, sometimes accompanied with pain or itching sensation. In some cases, however, sudden appearance of asymptomatic hyperpigmentation can be the only clinical finding of phytophotodermatitis. Here, we present two patients with sudden development of asymptomatic pigmentation on their hand without preceding inflammation by the contact with citrus fruits containing photosensitizers and subsequent exposure to strong sunlight...
February 2018: Annals of Dermatology
https://www.readbyqxmd.com/read/29385792/efficacy-of-micronized-purified-flavonoid-fraction-daflon%C3%A2-on-improving-individual-symptoms-signs-and-quality-of-life-in-patients-with-chronic-venous-disease-a-systematic-review-and-meta-analysis-of-randomized-double-blind-placebo-controlled-trials
#19
Stavros Kakkos, Andrew Nicolaides
INTRODUCTION: The use of a venoactive drug is considered an important component of medical treatment of chronic venous disease (CVD), although the efficacy of certain VADs on one or more individual leg symptoms or signs may have not been extensively studied to justify a strong recommendation in guidelines on CVD. The aim of this systematic review and metaanalysis was to study the effectiveness of the micronized purified flavonoid fraction (MPFF, Daflon®) across the spectrum of defined venous symptoms, signs, quality of life (QoL) and treatment assessment by the physician...
January 31, 2018: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/29383259/monitoring-of-atopic-dermatitis-using-leaky-coaxial-cable
#20
Binbin Dong, Aifeng Ren, Syed Aziz Shah, Fangming Hu, Nan Zhao, Xiaodong Yang, Daniyal Haider, Zhiya Zhang, Wei Zhao, Qammer Hussain Abbasi
In our daily life, inadvertent scratching may increase the severity of skin diseases (such as atopic dermatitis etc.). However, people rarely pay attention to this matter, so the known measurement behaviour of the movement is also very little. Nevertheless, the behaviour and frequency of scratching represent the degree of itching, and the analysis of scratching frequency is helpful to the doctor's clinical dosage. In this Letter, a novel system is proposed to monitor the scratching motion of a sleeping human body at night...
December 2017: Healthcare Technology Letters
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