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Jong Hae Kim, Eugene Kim, Bong Il Kim
RATIONALE: A variety of therapeutic modalities are available for the treatment of interstitial cystitis. However, among them, the less invasive therapies are usually ineffective, whereas the invasive ones carry potential risks of serious side effects and complications. Pulsed radiofrequency (PRF) treatment of the superior hypogastric plexus may be an alternative to conventional treatments, as it provides nondestructive neuromodulation to the superior hypogastric plexus, which transmits the majority of pain signals from the pelvic viscera...
December 2016: Medicine (Baltimore)
Te-Lu Yap, Yong Chen, Shireen A Nah, Caroline Choo Phaik Ong, Anette Jacobsen, Yee Low
AIM: Our study aimed to compare the efficacy of two endoscopic techniques used for the correction of vesicoureteral reflux (VUR): subureteral transurethral injection (STING) and hydrodistension implantation technique (HIT). METHODS: A systematic review was conducted using MEDLINE, Google scholar, and Cochrane databases from 1984 to 2015. Meta-analysis of the selected studies was performed to compare the extent of reflux resolution following both techniques. RESULTS: Six observational studies met the inclusion criteria for content...
December 2016: Journal of Pediatric Surgery
Kazuyuki Numakura, Norihiko Tsuchiya, Hiroshi Tsuruta, Susumu Akihama, Mitsuru Saito, Takamitsu Inoue, Shintaro Narita, Mingguo Huang, Shigeru Satoh, Tomonori Habuchi
OBJECTIVE: Intravesical BCG therapy is widely used for the treatment of high-risk, non-muscle-invasive bladder cancer. Among various reported side-effects, decreased bladder capacity is a serious side-effect that significantly worsens patients' quality of life. This article reports the efficacy and safety of bladder hydrodistension (BHD) in six patients with seriously decreased bladder capacity caused by BCG treatment. METHODS: Six patients with low bladder capacity (<100 ml in voiding diaries) and complaint of grade 3 irritative symptoms were diagnosed with decreased bladder capacity and treated with BHD...
December 2016: Scandinavian Journal of Urology
L Lorenzo, M A Bonillo, S Arlandis, E Martínez-Cuenca, L Marzullo, E Broseta, F Boronat
INTRODUCTION: For bladder pain syndrome (BPS) refractory to conservative treatment, the European guidelines consider bladder hydrodistention (HD) under anaesthesia and the injection of Onabotulinumtoxin A (OnabotA) jointly. The objective of this study was to assess our experience in implementing this technique. MATERIAL AND METHODS: A prospective study of 25 patients with BPS who underwent HD plus a submucosal injection of 100 U of OnabotA in trigone. The Hunner lesions were treated endoscopically using resection or electrocoagulation...
June 2016: Actas Urologicas Españolas
Hikaru Tomoe
BACKGROUND: Dimethylsulfoxide (DMSO) is the most-used agent for intravesical instillation. We conducted this retrospective clinical study to determine in what type of the interstitial cystitis (IC)/bladder pain syndrome (BPS) DMSO was effective. METHODS: We combined DMSO with hydrodistension in 2003 and from 2004 we performed hydrodistension alone. Hydrodistension had been performed in 7 cases of IC/BPS with Hunner's lesions (H group) and 7 cases of IC/BPS without Hunner's lesions (non-H group), and they served as the control group (C group; n=14)...
December 2015: Translational Andrology and Urology
Yukio Yamada, Akira Nomiya, Aya Niimi, Yasuhiko Igawa, Takaaki Ito, Hikaru Tomoe, Mineo Takei, Tomohiro Ueda, Yukio Homma
BACKGROUND: To explore the real-life practice of clinical management of interstitial cystitis (IC) in Japan. METHODS: A questionnaire on the number of IC patients, cystoscopic findings, diagnostic methods, and the treatment modalities was sent via e-mail to 114 medical institutions belonging to the Society of Interstitial Cystitis of Japan (SICJ). RESULTS: Completed questionnaires were returned from 62 institutions (20 university hospitals, 26 general hospitals and 16 clinics), with a response rate of 54%...
October 2015: Translational Andrology and Urology
Daichi Maeda, Yoshiyuki Akiyama, Teppei Morikawa, Akiko Kunita, Yasunori Ota, Hiroto Katoh, Aya Niimi, Akira Nomiya, Shumpei Ishikawa, Akiteru Goto, Yasuhiko Igawa, Masashi Fukayama, Yukio Homma
Interstitial cystitis (IC) is a chronic bladder disease with urinary frequency, bladder discomfort or bladder pain of unknown etiology. Based on cystoscopic findings, patients with IC are classified as either Hunner-type/classic IC (HIC), presenting with a specific Hunner lesion, or non-Hunner-type IC (NHIC), presenting with no Hunner lesion, but post-hydrodistension mucosal bleeding. Inflammatory cell infiltration, composed predominantly of lymphocytes, plasma cells and epithelial denudation, has in the past been documented as a major pathological IC finding...
2015: PloS One
Aya Niimi, Akira Nomiya, Yukio Yamada, Motofumi Suzuki, Tetsuya Fujimura, Hiroshi Fukuhara, Haruki Kume, Yasuhiko Igawa, Yukio Homma
AIMS: Hydrodistension of the bladder, with optional fulguration of Hunner lesions, is one of the recommended therapies for interstitial cystitis (IC). The aims of this study are to evaluate long-term outcomes of hydrodistension and identify outcome predictors. METHODS: The study cohort was 191 newly diagnosed IC patients (155 women and 36 men) who underwent hydrodistension with fulguration of Hunner lesions if detected between 2007 and 2013 at our institution. The primary outcome was therapeutic failure, which was defined as repeat hydrodistension, bladder instillation therapy, or narcotic use for pain control...
November 2016: Neurourology and Urodynamics
Chi-hang Yee, Pui-tak Lai, Wai-man Lee, Yuk-him Tam, Chi-fai Ng
OBJECTIVE: To assess the outcome of a prospective cohort of patients with ketamine-associated uropathy after standardized treatment. METHODS: This is a prospective case series of patients with ketamine-related urologic problems. Management for the patients includes a 4-tier approach, namely anti-inflammatory or anti-cholinergic drugs, opioid analgesics or pregabalin, intravesical hyaluronic acid, and finally, surgical intervention including hydrodistension and augmentation cystoplasty...
August 2015: Urology
Yoshiyuki Akiyama, Akira Nomiya, Aya Niimi, Yukio Yamada, Tetsuya Fujimura, Tohru Nakagawa, Hiroshi Fukuhara, Haruki Kume, Yasuhiko Igawa, Yukio Homma
OBJECTIVES: To determine whether botulinum toxin type A can represent an alternative treatment option for patients with interstitial cystitis refractory to conventional therapies. METHODS: This is a single-center, prospective, open labeled, randomized comparative study. Patients with refractory interstitial cystitis were randomly divided into two groups: immediate injection (group A) or 1-month delayed injection (group B) of botulinum toxin type A after allocation...
September 2015: International Journal of Urology: Official Journal of the Japanese Urological Association
Yuan-Hong Jiang, Hann-Chorng Kuo
OBJECTIVES: To investigate the urothelial dysfunction and inflammation of urinary bladder in patients with upper urinary tract (UUT) urolithiasis through the results of cystoscopic hydrodistension and immunohistochemistry study. METHODS: Ninety-one patients with UUT urolithiasis underwent cystoscopic hydrodistension before the stone surgery. Immunofluorescence staining of E-cadherin, zonula occludens-1 (ZO-1), tryptase (mast cell activation), and TUNEL (urothelial apoptosis) were performed in 42 patients with glomerulations after hydrodistension, 10 without glomerulations, and 10 controls...
2014: PloS One
Yigit Akin, Hakan Gulmez, Erol Güntekin, Mehmet Baykara, Selcuk Yucel
OBJECTIVE: The aim of this study was to investigate endoscopic treatment in children with primary vesicoureteral reflux (VUR) and conduct a multivariate analysis of factors for failure. MATERIAL AND METHODS: Between August 2006 and January 2012, 216 children (32 boys and 184 girls) with primary VUR (grades I-IV) who underwent endoscopic treatment were analysed. Patients with grade V VUR were excluded. Hydrodistension tests and intraureteral injection techniques were performed, if applicable...
December 2014: Scandinavian Journal of Urology
Frank Van der Aa, Ian Beckley, Dirk de Ridder
AIMS: To investigate the role of urinary BK polyoma virus (BKPyV) in the pathophysiology and prognosis of patients with painful bladder syndrome/interstitial cystitis (PBS/IC). METHODS: Urine samples were collected from 15 patients with PBS/IC and 8 control patients (with urolithiasis, overactive bladder and benign prostatic hyperplasia). BKPyV titres were quantitatively determined using real time PCR. Fisher's exact test was used to compare virus titre levels between the two groups...
September 2014: Medical Hypotheses
Tina Mazaheri, Mona Vahidi Rad, Mehdi Fareghi, Abdol-Mohammad Kajbafzadeh
Complete urethral duplication is a rare congenital genitourinary anomaly with various symptoms. Since anatomical place of urethra greatly varies between cases, surgical management of the patients is personalized according to the type of the duplication and requires a careful workup before planning for any intervention. In this case report, a 4-year-old boy with finding of complete proximal hypospadiac urethral duplication is presented with double-stream voiding. He was passing a normal stream of urine through the hypospadiac tract, while a thin stream came out from the normal meatal site...
September 2014: International Urology and Nephrology
Helen Otteno, Erica Smith, R Keith Huffaker
An 82-year-old female presented with longstanding history of both painful bladder syndrome and atrial fibrillation. She underwent hydrodistension remarkable for hematuria without temporary discontinuation of Dabigatran. Subsequently, patient was admitted to the hospital secondary to anemia and hemorrhagic cystitis.
2014: Case Reports in Urology
Jane Manning, Peter Dwyer, Anna Rosamilia, Kim Colyvas, Christine Murray, Elizabeth Fitzgerald
INTRODUCTION AND HYPOTHESIS: To determine if abobotulinumtoxin A (AboBTXA) is an effective treatment for interstitial cystitis/bladder pain syndrome (IC/BPS). METHODS: We performed a double-blind study of 54 women with severe, refractory IC from three referral centres whom we randomly allocated to treatment with hydrodistension + injection of normal saline or to hydrodistension + injection with AboBTXA. The O'Leary-Sant questionnaire consists of problem (OLS-PI) and symptom (OLS-PI) index scores, and bladder diary data were compared between AboBTXA and control patients at baseline and at 3 months of follow-up...
May 2014: International Urogynecology Journal
Liang Huang, Dongjie Li, Zhengyan Tang, Guilin Wang, Jian Ding, Kuan Luo, Ke Huang, Jie Zhou, Yonglin Li
OBJECTIVE: To determine the diagnosis, treatment, and pathogenesis of ketamine-associated cystitis. METHODS: Clinical data from 3 patients with ketamine-associated cystitis were analyzed retrospectively and discussed in light of relevant literature. RESULTS: In the 3 cases, 2 presented severe lower urinary tract symptoms, including frequency, urgency, dysuria, urge incontinence, and painful haematuria. Urinalysis and urine culture were negative...
September 2013: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Yuichi Katayama, Kozue Nakahara, Takahiro Shitamura, Shoichiro Mukai, Hironobu Wakeda, Yasuhiro Yamashita, Katsumi Inoue, Kiyotaka Nose, Toshiyuki Kamoto
The efficacy of acupuncture and moxibustion treatment was examined on eight female patients with refractory interstitial cystitis (IC) who had been treated conservatively with hydrodistension, intravesical instillation of dimethyl sulfoxide, or oral medication. These patients had received hydrodistension on an average of 2.3±1.8 times. Moxa needles were applied to Ciliao in bladder meridian 32 and Xialiao in bladder meridian 34, and electroacupuncture was performed on Zhongliao in bladder meridian 33 at 3 Hz for 20 min once a week...
May 2013: Hinyokika Kiyo. Acta Urologica Japonica
D Jocham, G Froehlich, F Sandig, A Ziegler
BACKGROUND: Using a comprehensive questionnaire the care situation of 270 patients with interstitial cystitis (IC) and bladder pain syndrome in Germany was recorded. Despite comprehensive literature on IC (62,000 citations in PubMed) almost nothing is known of the everyday care and quality of patient care in Germany. RESULTS: In total 94% of the patients were women and 6% men, the average age of women was 53.5 years and that of men 67 years and 47.77% of the patients felt that they were well or very well informed about the disease whereby the internet was the source of information in many cases...
May 2013: Der Urologe. Ausg. A
Akira Nomiya, Takashi Naruse, Aya Niimi, Hiroaki Nishimatsu, Haruki Kume, Yasuhiko Igawa, Yukio Homma
OBJECTIVES: To examine outcomes of intravesical instillations of heparin and alkalized lidocaine in patients with interstitial cystitis. METHODS: Patients with interstitial cystitis refractory to conventional therapies were given a solution of 20 000 U heparin, 5 mL 4% lidocaine and 25 mL 7% sodium bicarbonate, intravesically, weekly for 12 weeks consecutively. The treatment was regarded as "effective", when patients rated "slightly improved" or "better" on a seven-graded scale of global response assessment...
November 2013: International Journal of Urology: Official Journal of the Japanese Urological Association
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