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https://www.readbyqxmd.com/read/28442372/long-term-release-and-stability-of-pharmaceutical-proteins-delivered-from-solid-lipid-implants
#1
Moritz Vollrath, Julia Engert, Gerhard Winter
Solid lipid implants (SLIs) prepared by twin-screw (tsc) extrusion represent a promising technology platform for the sustained release of pharmaceutical proteins. In this work, we report on two aspects, long-term release and stability of released protein. First, SLIs were produced by tsc-extrusion containing the low melting triglyceride H12 and the high melting triglyceride Dynasan D118. Two different proteins available in a freeze-dried matrix containing hydroxypropyl-β-cyclodextrine (HP-β-CD) were incorporated into the lipid matrix: a monoclonal antibody (mAb) from the IgG1 class and the fab-fragment Ranibizumab (Lucentis(®))...
April 22, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28406048/placement-of-central-venous-port-catheters-and-peripherally-inserted-central-catheters-in-the-routine-clinical-setting-of-a-radiology-department-analysis-of-costs-and-intervention-duration-learning-curve
#2
Roman Rotzinger, Bernhard Gebauer, Dirk Schnapauff, Florian Streitparth, Gero Wieners, Christian Grieser, Patrick Freyhardt, Bernd Hamm, Martin H Maurer
Background Placement of central venous port catheters (CVPS) and peripherally inserted central catheters (PICC) is an integral component of state-of-the-art patient care. In the era of increasing cost awareness, it is desirable to have more information to comprehensively assess both procedures. Purpose To perform a retrospective analysis of interventional radiologic implantation of CVPS and PICC lines in a large patient population including a cost analysis of both methods as well as an investigation the learning curve in terms of the interventions' durations...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28398014/brain-responsive-neurostimulation-in-patients-with-medically-intractable-mesial-temporal-lobe-epilepsy
#3
Eric B Geller, Tara L Skarpaas, Robert E Gross, Robert R Goodman, Gregory L Barkley, Carl W Bazil, Michael J Berg, Gregory K Bergey, Sydney S Cash, Andrew J Cole, Robert B Duckrow, Jonathan C Edwards, Stephan Eisenschenk, James Fessler, Nathan B Fountain, Alicia M Goldman, Ryder P Gwinn, Christianne Heck, Aamar Herekar, Lawrence J Hirsch, Barbara C Jobst, David King-Stephens, Douglas R Labar, James W Leiphart, W Richard Marsh, Kimford J Meador, Eli M Mizrahi, Anthony M Murro, Dileep R Nair, Katherine H Noe, Yong D Park, Paul A Rutecki, Vicenta Salanova, Raj D Sheth, Donald C Shields, Christopher Skidmore, Michael C Smith, David C Spencer, Shraddha Srinivasan, William Tatum, Paul C Van Ness, David G Vossler, Robert E Wharen, Gregory A Worrell, Daniel Yoshor, Richard S Zimmerman, Kathy Cicora, Felice T Sun, Martha J Morrell
OBJECTIVE: Evaluate the seizure-reduction response and safety of mesial temporal lobe (MTL) brain-responsive stimulation in adults with medically intractable partial-onset seizures of mesial temporal lobe origin. METHODS: Subjects with mesial temporal lobe epilepsy (MTLE) were identified from prospective clinical trials of a brain-responsive neurostimulator (RNS System, NeuroPace). The seizure reduction over years 2-6 postimplantation was calculated by assessing the seizure frequency compared to a preimplantation baseline...
April 11, 2017: Epilepsia
https://www.readbyqxmd.com/read/28377897/relationship-of-number-of-embryos-transferred-with-perinatal-outcome-of-singleton-pregnancy
#4
Shilpa Bhandari, Ishita Ganguly, Pallavi Agarwal, Niharika Munaganuru, Nitika Gupta, Aparna Singh
BACKGROUND: Singleton pregnancy with a live birth beyond 37 weeks of gestation is the ultimate goal of any assisted reproductive technology. However, singletons conceived after ART are found to have a poor perinatal outcome in comparison to naturally conceived singletons. It was hypothesized that the outcome of singleton conceived after transfer of two or more embryos may be dependent on the sharing of uterine space with other embryos. METHODS: Patients who had single gestational sac visualized at 6 weeks after transfer of 4, 3 or 2 embryos were considered for the study...
January 2017: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/28343651/reconstruction-of-large-cranial-defects-with-poly-methyl-methacrylate-pmma-using-a-rapid-prototyping-model-and-a-new-technique-for-intraoperative-implant-modeling
#5
Claudia Unterhofer, Christoph Wipplinger, Michael Verius, Wolfgang Recheis, Claudius Thomé, Martin Ortler
BACKGROUND: Reconstruction of large cranial defects after craniectomy can be accomplished by free-hand poly-methyl-methacrylate (PMMA) or industrially manufactured implants. The free-hand technique often does not achieve satisfactory cosmetic results but is inexpensive. In an attempt to combine the accuracy of specifically manufactured implants with low cost of PMMA. METHODS: Forty-six consecutive patients with large skull defects after trauma or infection were retrospectively analyzed...
March 10, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28185409/a-retrospective-study-on-1592-consecutively-performed-operations-in-one-private-referral-clinic-part-i-early-inflammation-and-early-implant-failures
#6
Hadi Antoun, Michel Karouni, Jérémy Abitbol, Ons Zouiten, Torsten Jemt
BACKGROUND: Few large-scale follow-up studies are reported on routine implant treatment. PURPOSE: To report retrospective data on early inflammatory and early implant failures in a large number of routine patients at one private referral clinic. MATERIALS AND METHODS: A total of 1017 patients were consecutively provided with 3082 implants with an anodized surface (Nobel Biocare AB) at 1592 implant operations between 2000 and 2011. All patients reported with mucosa inflammation and bone loss and/or implant failures to the first annual examination were identified...
February 10, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28093860/monolithic-implant-supported-lithium-disilicate-ls2-crowns-in-a-complete-digital-workflow-a-prospective-clinical-trial-with-a-2-year-follow-up
#7
Tim Joda, Marco Ferrari, Urs Brägger
BACKGROUND: The technical development of digital processing allows the production of anatomically full-contoured implant-supported restorations. PURPOSE: The aim of this prospective clinical trial was to analyze the treatment concept of monolithic lithium disilicate (LS2) single-unit restorations in a complete digital workflow. MATERIAL AND METHODS: Forty-four patients were restored with 50 screw-retained monolithic implant LS2 crowns bonded to pre-fabricated titanium abutments on soft tissue level implants (Institut Straumann AG, Basel, Switzerland) in premolar and molar sites...
January 16, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28063250/comparative-3d-micro-ct-and-2d-histomorphometry-analysis-of-dental-implant-osseointegration-in-the-maxilla-of-minipigs
#8
Oliver Bissinger, Florian Andreas Probst, Klaus-Dietrich Wolff, Anke Jeschke, Jochen Weitz, Herbert Deppe, Andreas Kolk
AIM: The bone implant contact (BIC) has traditionally been evaluated with histological methods. Thereupon, strong correlations of two-dimensional (2D) BIC have been detected between μCT and destructive histology. However, due to the high intra-sample variability in BIC values, one histological slice is not sufficient to represent 3D BIC. Therefore, our aim has been to correlate the averaged values of 3-4 histological sections to 3D μCT. MATERIAL AND METHODS: Fifty-four implants inserted into the maxilla of 14 minipigs were evaluated...
January 7, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28032908/adjunctive-efficacy-of-probiotics-in-the-treatment-of-experimental-peri-implant-mucositis-with-mechanical-and-photodynamic-therapy-a-randomized-cross-over-clinical-trial
#9
Claudio Mongardini, Andrea Pilloni, Roberto Farina, Gianluca Di Tanna, Blerina Zeza
AIM: To evaluate the adjunctive clinical efficacy of probiotics in the treatment of peri-implant mucositis (p-iM) with professionally administered plaque removal (PAPR) and photodynamic therapy (PDT). MATERIALS AND METHODS: Following p-iM induction, patients underwent PAPR + PDT and were randomly assigned to receive the professional and home-based administration of probiotics (Lactobacillus plantarum and Lactobacillus brevis) (test treatment) or placebo preparation (control treatment) according to a cross-over design...
December 29, 2016: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/27884358/application-of-3-dimensional-computed-tomographic-image-guidance-to-watchman-implantation-and-impact-on%C3%A2-early-operator-learning-curve-single-center-experience
#10
Dee Dee Wang, Marvin Eng, Daniel Kupsky, Eric Myers, Michael Forbes, Mehnaz Rahman, Mohammad Zaidan, Sachin Parikh, Janet Wyman, Milan Pantelic, Thomas Song, Jeff Nadig, Patrick Karabon, Adam Greenbaum, William O'Neill
OBJECTIVES: The aim of this study was to examine the impact of 3-dimensional (3D) computed tomographic (CT) guided procedural planning for left atrial appendage (LAA) occlusion on the early operator WATCHMAN learning curve. BACKGROUND: Traditional WATCHMAN implantation is dependent on 2-dimensional transesophageal echocardiographic (TEE) sizing and intraprocedural guidance. METHODS: LAA occlusion with the WATCHMAN device was performed in 53 patients...
November 28, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27639485/how-does-implant-distribution-affect-3d-correction-and-bone-screw-forces-in-thoracic-adolescent-idiopathic-scoliosis-spinal-instrumentation
#11
Franck Le Navéaux, A Noelle Larson, Hubert Labelle, Xiaoyu Wang, Carl-Éric Aubin
BACKGROUND: Optimal implant densities and configurations for thoracic spine instrumentation to treat adolescent idiopathic scoliosis remain unknown. The objective was to computationally assess the biomechanical effects of implant distribution on 3D curve correction and bone-implant forces. METHODS: 3D patient-specific biomechanical spine models based on a multibody dynamic approach were created for 9 Lenke 1 patients who underwent posterior instrumentation (main thoracic Cobb: 43°-70°)...
November 2016: Clinical Biomechanics
https://www.readbyqxmd.com/read/27553255/a-prospective-clinical-cohort-study-analyzing-single-unit-implant-crowns-after-three-years-of-loading-introduction-of-a-novel-functional-implant-prosthodontic-score-fips
#12
Tim Joda, Marco Ferrari, Urs Bragger
OBJECTIVES: The aim of this prospective clinical cohort study was to validate implant crowns with a novel Functional Implant Prosthodontic Score (FIPS). MATERIAL AND METHODS: Twenty patients were restored with cement-retained crowns on soft tissue level implants (Institut Straumann AG, Basel, Switzerland) in posterior sites and annually followed-up for 3 years. FIPS was applied for the objective outcome assessment including clinical and radiographic examinations...
August 23, 2016: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/27504130/clinical-applications-of-custom-made-vaginal-cylinders-constructed-using-three-dimensional-printing-technology
#13
Rajni Sethi, Adam Cunha, Katherine Mellis, Timmy Siauw, Chris Diederich, Jean Pouliot, I-Chow Hsu
PURPOSE: Three-dimensional (3D) printing technology allows physicians to rapidly create customized devices for patients. We report our initial clinical experience using this technology to create custom applicators for vaginal brachytherapy. MATERIAL AND METHODS: Three brachytherapy patients with unique clinical needs were identified as likely to benefit from a customized vaginal applicator. Patient 1 underwent intracavitary vaginal cuff brachytherapy after hysterectomy and chemotherapy for stage IA papillary serous endometrial cancer using a custom printed 2...
June 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/27499645/first-in-human-phase-1-trial-of-agarose-beads-containing-murine-renca-cells-in-advanced-solid-tumors
#14
Barry H Smith, Tapan Parikh, Zoe P Andrada, Thomas J Fahey, Nathaniel Berman, Madeline Wiles, Angelica Nazarian, Joanne Thomas, Anna Arreglado, Eugene Akahoho, David J Wolf, Daniel M Levine, Thomas S Parker, Lawrence S Gazda, Allyson J Ocean
PURPOSE: Agarose macrobeads containing mouse renal adenocarcinoma cells (RMBs) release factors, suppressing the growth of cancer cells and prolonging survival in spontaneous or induced tumor animals, mediated, in part, by increased levels of myocyte-enhancing factor (MEF2D) via EGFR-and AKT-signaling pathways. The primary objective of this study was to determine the safety of RMBs in advanced, treatment-resistant metastatic cancers, and then its efficacy (survival), which is the secondary objective...
2016: Cancer Growth and Metastasis
https://www.readbyqxmd.com/read/27250841/predisposing-factors-for-adverse-skin-reactions-with-percutaneous-bone-anchored-hearing-devices-implanted-with-skin-reduction-techniques
#15
Claudia Candreia, Ruth Birrer, Susanna Fistarol, Martin Kompis, Marco Caversaccio, Andreas Arnold, Christof Stieger
We present an analysis of adverse events after implantation of bone anchored hearing device in our patient population with focus on individual risk factors for peri-implant skin reactions. The investigation involved a chart review of adult Baha patients (n = 179) with 203 Bahas implanted with skin reduction techniques between 1993 and 2009, a questionnaire (n = 97) and a free clinical examination (n = 47). Skin reactions were graded by severity from 0 (no skin reaction) to 4 (implant loss resulting from infection) according to Holgers...
December 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27183085/bactericidal-effect-of-erbium-doped-yttrium-aluminum-garnet-laser-and-photodynamic-therapy-on-aggregatibacter-actinomycetemcomitans-biofilm-on-implant-surface
#16
Anna Saffarpour, Reza Fekrazad, Maryam Naghavi Heibati, Abbas Bahador, Aida Saffarpour, Amir R Rokn, Aysel Iranparvar, Mohammad J KharaziFard
PURPOSE: Peri-implantitis is a common complication of dental implants. The first step of treatment is elimination of bacterial biofilm and disinfection of the implant surface. This study sought to compare the effects of an erbium-doped yttrium aluminum garnet (Er:YAG) laser, photodynamic therapy using an indocyanin green-based photosensitizer (ICG-based PS) and diode laser, toluidine blue O (TBO) photosensitizer and light-emitting diode (LED) light source, and 2% chlorhexidine (CHX) on biofilm of Aggregatibacter actinomycetemcomitans to sandblasted, large-grit, acid-etched (SLA) implant surfaces...
May 2016: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/27176560/a-novel-nonviral-gene-delivery-tool-of-bmp-2-for-the-reconstitution-of-critical-size-bone-defects-in-rats
#17
Andreas Kolk, Thomas Tischer, Christian Koch, Stephan Vogt, Bernhard Haller, Ralf Smeets, Kilian Kreutzer, Christian Plank, Oliver Bissinger
The osseointegration of bone implants, implant failure, and the bridging of critical-size bone defects are frequent clinical challenges. Deficiencies in endogenous bone healing can be resolved through the local administration of suitable recombinant growth factors (GFs). In preclinical models, gene-therapy-supported bone healing has proven promising for overcoming certain limitations of GFs. We report the dose-dependent bridging of critical-size mandibular bone defects (CSDs) in a rat model using a non-viral BMP-2-encoding copolymer-protected gene vector (pBMP-2) embedded in poly(d, l-lactide) (PDLLA) coatings on titanium discs that were used to cover drill holes in the mandibles of 53 male Sprague Dawley rats...
October 2016: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27165612/salvage-high-dose-rate-brachytherapy-for-locally-recurrent-prostate-cancer-after-primary-radiotherapy-failure
#18
Piotr Wojcieszek, Marta Szlag, Grzegorz Głowacki, Agnieszka Cholewka, Marzena Gawkowska-Suwińska, Sylwia Kellas-Ślęczka, Brygida Białas, Marek Fijałkowski
BACKGROUND AND PURPOSE: To evaluate high-dose-rate brachytherapy (HDR BT) as a salvage modality for locally recurrent prostate cancer after primary radiotherapy failure. MATERIALS AND METHODS: Eighty-three prostate cancer patients, who locally relapsed after radiotherapy, were treated with salvage HDR BT. The schedule was three implantations, every two weeks, with 10Gy per implant, to a total dose of 30Gy. Acute and late toxicity rates were evaluated. Overall survival (OS) and biochemical control were calculated using Kaplan-Meier method...
June 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/26774671/the-biomechanical-effect-of-anteversion-and-modular-neck-offset-on-stress-shielding-for-short-stem-versus-conventional-long-stem-hip-implants
#19
COMPARATIVE STUDY
Peter Goshulak, Saeid Samiezadeh, Mina S R Aziz, Habiba Bougherara, Radovan Zdero, Emil H Schemitsch
Short-stem hip implants are increasingly common since they preserve host bone stock and presumably reduce stress shielding by improving load distribution in the proximal femur. Stress shielding may lead to decreased bone density, implant loosening, and fracture. However, few biomechanical studies have examined short-stem hip implants. The purpose of this study was to compare short-stem vs. standard length stemmed implants for stress shielding effects due to anteversion-retroversion, anterior-posterior position, and modular neck offset...
March 2016: Medical Engineering & Physics
https://www.readbyqxmd.com/read/26699289/practical-considerations-in-the-selection-of-seed-strength-for-prostate-implants
#20
Sarah L Elliott, Catherine L Beaufort, Jeremy L Millar
There are advantages in using lower numbers of higher activity seeds for prostate seed implants. This work investigated the use of higher strength seeds for our manually optimized prostate implants. Following a planning study using a range of seeds strengths between 0.4 U and 0.7 U, a series of patients were implanted using seeds of strength ~ 0.7 U. Twenty consecutive patients were selected for this study; ten patients were implanted with 0.4 U seeds and the next ten patients implanted with 0.7 U seeds. Postimplant dosimetry for the target volume, urethra, and rectal wall was compared between the two groups...
September 8, 2015: Journal of Applied Clinical Medical Physics
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