Read by QxMD icon Read


Franck Le Navéaux, A Noelle Larson, Hubert Labelle, Xiaoyu Wang, Carl-Éric Aubin
BACKGROUND: Optimal implant densities and configurations for thoracic spine instrumentation to treat adolescent idiopathic scoliosis remain unknown. The objective was to computationally assess the biomechanical effects of implant distribution on 3D curve correction and bone-implant forces. METHODS: 3D patient-specific biomechanical spine models based on a multibody dynamic approach were created for 9 Lenke 1 patients who underwent posterior instrumentation (main thoracic Cobb: 43°-70°)...
September 9, 2016: Clinical Biomechanics
Tim Joda, Marco Ferrari, Urs Bragger
OBJECTIVES: The aim of this prospective clinical cohort study was to validate implant crowns with a novel Functional Implant Prosthodontic Score (FIPS). MATERIAL AND METHODS: Twenty patients were restored with cement-retained crowns on soft tissue level implants (Institut Straumann AG, Basel, Switzerland) in posterior sites and annually followed-up for 3 years. FIPS was applied for the objective outcome assessment including clinical and radiographic examinations...
August 23, 2016: Clinical Oral Implants Research
Rajni Sethi, Adam Cunha, Katherine Mellis, Timmy Siauw, Chris Diederich, Jean Pouliot, I-Chow Hsu
PURPOSE: Three-dimensional (3D) printing technology allows physicians to rapidly create customized devices for patients. We report our initial clinical experience using this technology to create custom applicators for vaginal brachytherapy. MATERIAL AND METHODS: Three brachytherapy patients with unique clinical needs were identified as likely to benefit from a customized vaginal applicator. Patient 1 underwent intracavitary vaginal cuff brachytherapy after hysterectomy and chemotherapy for stage IA papillary serous endometrial cancer using a custom printed 2...
June 2016: Journal of Contemporary Brachytherapy
Barry H Smith, Tapan Parikh, Zoe P Andrada, Thomas J Fahey, Nathaniel Berman, Madeline Wiles, Angelica Nazarian, Joanne Thomas, Anna Arreglado, Eugene Akahoho, David J Wolf, Daniel M Levine, Thomas S Parker, Lawrence S Gazda, Allyson J Ocean
PURPOSE: Agarose macrobeads containing mouse renal adenocarcinoma cells (RMBs) release factors, suppressing the growth of cancer cells and prolonging survival in spontaneous or induced tumor animals, mediated, in part, by increased levels of myocyte-enhancing factor (MEF2D) via EGFR-and AKT-signaling pathways. The primary objective of this study was to determine the safety of RMBs in advanced, treatment-resistant metastatic cancers, and then its efficacy (survival), which is the secondary objective...
2016: Cancer Growth and Metastasis
Claudia Candreia, Ruth Birrer, Susanna Fistarol, Martin Kompis, Marco Caversaccio, Andreas Arnold, Christof Stieger
We present an analysis of adverse events after implantation of bone anchored hearing device in our patient population with focus on individual risk factors for peri-implant skin reactions. The investigation involved a chart review of adult Baha patients (n = 179) with 203 Bahas implanted with skin reduction techniques between 1993 and 2009, a questionnaire (n = 97) and a free clinical examination (n = 47). Skin reactions were graded by severity from 0 (no skin reaction) to 4 (implant loss resulting from infection) according to Holgers...
June 1, 2016: European Archives of Oto-rhino-laryngology
Anna Saffarpour, Reza Fekrazad, Maryam Naghavi Heibati, Abbas Bahador, Aida Saffarpour, Amir R Rokn, Aysel Iranparvar, Mohammad J KharaziFard
PURPOSE: Peri-implantitis is a common complication of dental implants. The first step of treatment is elimination of bacterial biofilm and disinfection of the implant surface. This study sought to compare the effects of an erbium-doped yttrium aluminum garnet (Er:YAG) laser, photodynamic therapy using an indocyanin green-based photosensitizer (ICG-based PS) and diode laser, toluidine blue O (TBO) photosensitizer and light-emitting diode (LED) light source, and 2% chlorhexidine (CHX) on biofilm of Aggregatibacter actinomycetemcomitans to sandblasted, large-grit, acid-etched (SLA) implant surfaces...
May 2016: International Journal of Oral & Maxillofacial Implants
Andreas Kolk, Thomas Tischer, Christian Koch, Stephan Vogt, Bernhard Haller, Ralf Smeets, Kilian Kreutzer, Christian Plank, Oliver Bissinger
The osseointegration of bone implants, implant failure, and the bridging of critical-size bone defects are frequent clinical challenges. Deficiencies in endogenous bone healing can be resolved through the local administration of suitable recombinant growth factors (GFs). In preclinical models, gene-therapy-supported bone healing has proven promising for overcoming certain limitations of GFs. We report the dose-dependent bridging of critical-size mandibular bone defects (CSDs) in a rat model using a non-viral BMP-2-encoding copolymer-protected gene vector (pBMP-2) embedded in poly(d, l-lactide) (PDLLA) coatings on titanium discs that were used to cover drill holes in the mandibles of 53 male Sprague Dawley rats...
October 2016: Journal of Biomedical Materials Research. Part A
Piotr Wojcieszek, Marta Szlag, Grzegorz Głowacki, Agnieszka Cholewka, Marzena Gawkowska-Suwińska, Sylwia Kellas-Ślęczka, Brygida Białas, Marek Fijałkowski
BACKGROUND AND PURPOSE: To evaluate high-dose-rate brachytherapy (HDR BT) as a salvage modality for locally recurrent prostate cancer after primary radiotherapy failure. MATERIALS AND METHODS: Eighty-three prostate cancer patients, who locally relapsed after radiotherapy, were treated with salvage HDR BT. The schedule was three implantations, every two weeks, with 10Gy per implant, to a total dose of 30Gy. Acute and late toxicity rates were evaluated. Overall survival (OS) and biochemical control were calculated using Kaplan-Meier method...
June 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Peter Goshulak, Saeid Samiezadeh, Mina S R Aziz, Habiba Bougherara, Radovan Zdero, Emil H Schemitsch
Short-stem hip implants are increasingly common since they preserve host bone stock and presumably reduce stress shielding by improving load distribution in the proximal femur. Stress shielding may lead to decreased bone density, implant loosening, and fracture. However, few biomechanical studies have examined short-stem hip implants. The purpose of this study was to compare short-stem vs. standard length stemmed implants for stress shielding effects due to anteversion-retroversion, anterior-posterior position, and modular neck offset...
March 2016: Medical Engineering & Physics
Sarah L Elliott, Catherine L Beaufort, Jeremy L Millar
There are advantages in using lower numbers of higher activity seeds for prostate seed implants. This work investigated the use of higher strength seeds for our manually optimized prostate implants. Following a planning study using a range of seeds strengths between 0.4 U and 0.7 U, a series of patients were implanted using seeds of strength ~ 0.7 U. Twenty consecutive patients were selected for this study; ten patients were implanted with 0.4 U seeds and the next ten patients implanted with 0.7 U seeds. Postimplant dosimetry for the target volume, urethra, and rectal wall was compared between the two groups...
2015: Journal of Applied Clinical Medical Physics
Michelle Abghari, Alejandro Marcano, Roy Davidovitch, Sanjit R Konda, Kenneth A Egol
Displaced tibial plateau fractures often require surgical treatment and plate and screw constructs are the most common method of fixation. There has been increased usage of locking plate technology for both complex and simple fracture patterns without any evidence demonstrating their advantage. The purpose of this study was to compare the clinical use of locked versus nonlocked plating for repair of displaced Schatzker type-II (OTA Type 41B) tibial plateau fractures. Seventy-seven consecutive patients treated operatively with one of two types of plate and screw constructs in a nonrandomized fashion for Schatzker type II tibial plateau fractures and they were prospectively followed over a 5-year period...
August 2016: Journal of Knee Surgery
M A Elsyad, F F Mahanna, M A Elshahat, A H Elshoukouki
This study aimed to evaluate peri-implant tissue health of immediate loaded two implants retaining a mandibular overdenture with either magnetic or locator attachment. Thirty two completely edentulous patients (20 males/12 females) were randomly assigned into two groups. Each patient received two implants in the canine area of the mandible using flapless surgical technique. Mandibular overdentures were immediately connected to the implants with either magnetic (group I, GI) or locator (group II, GII) attachments...
April 2016: Journal of Oral Rehabilitation
Christine A den Besten, Emilie Harterink, Ann-Louise McDermott, Myrthe K S Hol
OBJECTIVES: To evaluate clinical outcomes of the Cochlear™ BIA300 in the pediatric population. STUDY DESIGN: Historical cohort study. SETTING: Two tertiary referral centers. PATIENTS: All patients implanted with the BIA300 from November 2011 to January 2014 and 17 years or younger during surgery were included in this cohort study. MAIN OUTCOME MEASURES: Number of soft tissue reaction scores according to Holgers, local and systemic treatment of soft tissue reactions, revision surgeries and implant loss...
December 2015: International Journal of Pediatric Otorhinolaryngology
Takashi Kubo, Takashi Akasaka, Ken Kozuma, Kazuo Kimura, Masaki Kawamura, Tetsuya Sumiyoshi, Yasushi Ino, Yoshihiro Morino, Kengo Tanabe, Kazushige Kadota, Takeshi Kimura
AIMS: The aim of the present study was to compare vascular healing response between the first-generation sirolimus-eluting stent (SES) and the second-generation everolimus-eluting stent (EES) by using optical coherence tomography (OCT). METHODS AND RESULTS: The RESET was a prospective, multicentre, randomised, open-label trial comparing EES and SES. Of the 3,197 patients enrolled in the RESET, nine-month follow-up OCT after stent implantation was performed in 100 patients (48 EES-treated lesions in 44 patients and 62 SES-treated lesions in 56 patients), thus constituting the OCT substudy population...
September 2015: EuroIntervention
Young-Bong Ko, Manan Ramesh Gujarathi, Kwang-Jun Oh
The purpose of this systematic review is to collate results of studies comparing fixed and mobile bearing unicompartmental knee arthroplasty (UKA), focusing on complications and timing for reoperations. Out of 723 results derived from PubMed, EMBASE and Cochrane database search engines on bearings in arthroplasty, 10 studies comparing clinical results of fixed bearings to mobile bearings in UKA were found eligible for analysis. The reoperation rate was calculated using a novel method such as reoperations per hundred component years, and the causes of specific reoperations were investigated...
September 2015: Knee Surgery & related Research
Chinnakart Boonyasirikool, Sakkarin Tanakeatsakul, Sunyarn Niempoog
BACKGROUND: The optimal fixation of metacarpal fracture should provide sufficient stability to permit early functionfor all types of fracture. However; it must preserve surrounding soft tissue during application and not require secondary removal due to its prominence. The prototype of metacarpal locked intramedullary nail (MCLN) was designed by our institute aiming to achieve those allfeatures. OBJECTIVE: To biomechanically test our newly designed, locked metacarpal nail and compare with common current available fixation methods...
April 2015: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Hiroyoshi Kawamoto, Neil Ruparelia, Azeem Latib, Tadashi Miyazaki, Katsumasa Sato, Antonio Mangieri, Rachele Contri, Stefano Stella, Filippo Figini, Alaide Chieffo, Mauro Carlino, Matteo Montorfano, Antonio Colombo
OBJECTIVES: This study aimed to investigate the clinical outcomes of patients presenting with recurrent drug-eluting stent (DES) in-stent restenosis (ISR) treated with a second-generation DES or with a drug-coated balloon (DCB). BACKGROUND: To date, there are no reports of DCB treatment and limited data with regard to the efficacy of further DES implantation for recurrent ISR. METHODS: Between January 2008 and December 2013, 171 lesions were assessed for eligibility (82 lesions in the second-generation DES group and 89 lesions in the DCB group)...
October 2015: JACC. Cardiovascular Interventions
Wonmo Kang, Ye-Rang Yun, Dong-Sung Lee, Tae-Hyun Kim, Joong-Hyun Kim, Hae-Won Kim, Jun-Hyeog Jang
The sustained release of growth factors following their implantation in vivo is essential for successful outcomes in bone tissue engineering. In this study, we evaluated the release kinetics and delivery efficacies of vascular endothelial growth factor (VEGF), a potent angiogenic growth factor, incorporated into calcium phosphate bone grafts (BGs). We evaluated the release profile of VEGF from BGs using a novel fluorescence-based retention assay, which revealed that VEGF loaded on BGs can be released in a sustained manner without an initial burst (near zero-order cumulative release) with a controlled release rate of 13...
January 2016: Journal of Biomedical Materials Research. Part A
John H Kempen, Mark L Van Natta, Michael M Altaweel, James P Dunn, Douglas A Jabs, Susan L Lightman, Jennifer E Thorne, Janet T Holbrook
PURPOSE: To identify factors associated with best-corrected visual acuity (BCVA) presentation and 2-year outcome in 479 intermediate, posterior, and panuveitic eyes. DESIGN: Cohort study using randomized controlled trial data. METHODS: Multicenter Uveitis Steroid Treatment (MUST) Trial masked BCVA measurements at baseline and at 2 years follow-up used gold-standard methods. Twenty-three clinical centers documented characteristics per protocol, which were evaluated as potential predictive factors for baseline BCVA and 2-year change in BCVA...
December 2015: American Journal of Ophthalmology
Hugo De Bruyn, Stefanie Raes, Carine Matthys, Jan Cosyn
AIM: To provide an update on the use of Patient-Reported Outcome Measures (PROMs) in the field of implant dentistry (1); to compare PROMs for prostheses supported by one or more implants to alternative treatment options or a healthy dentition (2). MATERIALS AND METHODS: The dental literature was searched on PubMed until December 31, 2014, using a general search algorithm. An overall quantitative analysis was performed, and a qualitative appraisal was made on the output of the last 6 years...
September 2015: Clinical Oral Implants Research
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"