Qianqian Wu, Runjiao Yang, Wenxuan Fan, Li Wang, Jing Zhan, Tingting Cao, Qiming Liu, Xianshu Piao, Yinghui Zhong, Wenxian Zhao, Shuhan Zhang, Jiaao Yu, Song Liang, Thomas M Roberts, Bingdi Wang, Zhenning Liu
The inflammatory response is a key factor affecting tissue regeneration. Inspired by the immunomodulatory role of spermidine, an injectable double network hydrogel functionalized with spermidine (DN-SPD) is developed, where the first and second networks are formed by dynamic imine bonds and non-dynamic photo-crosslinked bonds respectively. The single network hydrogel before photo-crosslinking exhibits excellent injectability and thus can be printed and photo-crosslinked in situ to form double network hydrogels...
April 11, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)