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https://www.readbyqxmd.com/read/27914063/episweep-computationally-driven-reengineering-of-therapeutic-proteins-to-reduce-immunogenicity-while-maintaining-function
#1
Yoonjoo Choi, Deeptak Verma, Karl E Griswold, Chris Bailey-Kellogg
Therapeutic proteins are yielding ever more advanced and efficacious new drugs, but the biological origins of these highly effective therapeutics render them subject to immune surveillance within the patient's body. When recognized by the immune system as a foreign agent, protein drugs elicit a coordinated response that can manifest a range of clinical complications including rapid drug clearance, loss of functionality and efficacy, delayed infusion-like allergic reactions, more serious anaphylactic shock, and even induced auto-immunity...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27913710/lessons-learned-from-35-cases-of-laryngeal-foreign-bodies-undergoing-misdiagnosis-in-pediatric-population
#2
Qingguo Chen, Hanqi Chu, Yanling Tao, Hongyan Huang, Liyan Peng
OBJECTIVES: To present 35 cases of laryngeal foreign bodies (FBs) in pediatric population undergoing misdiagnosis so as to draw on our lessons to improve early diagnosis. METHODS: A retrospective analysis over 15 years was conducted of 35 cases of laryngeal FBs undergoing misdiagnosis in children. Meanwhile, a control group, including 42 cases of laryngeal FBs without misdiagnosis in children, was set. These patients' clinical data were collected and analyzed to identify the risk factors for misdiagnosis...
December 2, 2016: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/27913297/phospholipase-c%C3%AE-1-suppresses-foreign-body-giant-cell-formation-by-maintaining-runx1-expression-in-macrophages
#3
Ye Seon Kim, Chang Youp Ok, Joon Seong Park, Ha Young Lee, Yoe-Sik Bae
Foreign body giant cell (FBGC) formation is associated with the inflammatory response following material implantation. However, the intracellular signaling events that regulate the process remain unclear. Here, we investigated the potential role of phospholipase C (PLC)γ1, a crucial enzyme required for growth factor-induced signaling, on FBGC formation. Knock-down of PLCγ1 using shRNA induced FBGC formation accompanied by increased expression of cathepsin K, DC-STAMP and CD36. Re-addition of PLCγ1 decreased FBGC formation...
November 29, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27910171/results-of-computed-tomography-in-dogs-with-suspected-wooden-foreign-bodies
#4
Christopher R Lamb, Elizabeth H W Pope, Karla C L Lee
Detection of wooden foreign bodies in dogs can be challenging. A retrospective, cross-sectional study was done to describe computed tomographic (CT) signs associated with wooden foreign bodies, and to estimate the accuracy of CT for detection of wooden foreign bodies. Patient records and CT images were reviewed for 72 dogs that had a history of suspected stick injury and CT of the affected body part, or possible wooden foreign object reported on CT, and had surgical exploration during the same period of hospitalization...
December 1, 2016: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/27907820/preauricular-pilomatricoma-an-uncommon-entity-in-a-dental-pediatric-patient
#5
Poyzan Bozkurt, Mehmet Eray Kolsuz, Ömer Günhan, Erdal Erdem, Kaan Orhan
INTRODUCTION: Pilomatricomas are benign follicular skin appendage tumors, commonly occurring in children and young adults. Most patients admit to dermatologists to seek treatment and are well known by them; however, dental professionals, especially pediatric dentists are not familiar with these tumors. PRESENTATION OF CASE: This report presents a 16-year-old female with preauricular pilomatricoma, located beneath the overlying skin of the temporomandibular region...
November 15, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27906854/a-bullet-lying-next-to-the-common-carotid-artery-in-the-neck-of-a-young-boy
#6
Gülpembe Bozkurt, Meltem Esen Akpinar, Özlem Ünsal, Berna Uslu Coşkun
Penetrating neck trauma is most commonly caused by firearm discharge, and is potentially very dangerous, being associated with a high risk of mortality. A 12-year-old patient with a recent history of a gunshot wound to the neck was evaluated in detail; a bullet was located in close proximity to the left common carotid artery. Neck exploration was performed and the foreign body was removed without any complications. The management of the patient is discussed, as are contemporary approaches to the treatment of penetrating neck trauma...
November 30, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27904842/the-challenges-of-cardiothoracic-surgery-practice-in-nigeria-a-12-years-institutional-experience
#7
Bode Falase, Michael Sanusi, Adeola Animasahun, Ogadinma Mgbajah, Adetinuwe Majekodunmi, Onyekwelu Nzewi, Jonathan Nwiloh, David Oke
BACKGROUND: Although the specialty of cardiothoracic surgery has been practiced in Nigeria for many years, open heart surgery (OHS) has only in the last decade become relatively more frequent, mainly through visiting foreign cardiac surgical teams. At this early phase of development it is faced with multiple challenges, especially financing and local skilled manpower for which solutions have to be identified in order to ensure sustainability and future growth. This study is aimed at highlighting these obstacles to growth of cardiothoracic surgery based on our own institutional experience at Lagos State University Teaching Hospital (LASUTH) and the current status of OHS activity in other cardiothoracic centers in Nigeria...
October 2016: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/27904758/penetrating-thoracic-spinal-cord-injury-with-ice-pick-extending-into-the-aorta-a-technical-note-and-review-of-the-literature
#8
Rani Nasser, Jonathan Nakhla, Saadat Sharif, Merritt Kinon, Reza Yassari
BACKGROUND: Penetrating spinal cord injuries pose a great challenge to both patients and the treating physicians. Although the overall incidence of penetrating spinal cord injury is the highest in the military, the ubiquity of guns in our society continues to make penetrating spinal cord injury prevalent in the civilian population. These types of injuries are particularly complicated because, beyond the trauma to the neural elements and supporting structures, other organs can be affected and a team approach is required for successful treatment...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27903951/a-management-algorithm-for-retained-rectal-foreign-bodies
#9
Shamir O Cawich, Dexter A Thomas, Fawwaz Mohammed, Nahmorah J Bobb, Dorothy Williams, Vijay Naraynsingh
Few authors have proposed therapeutic protocols to manage retained rectal foreign bodies (RFBs). All patients with retained RFBs in hospitals across Trinidad and Tobago over 5 years were identified. Hospital records were retrieved and manually reviewed to extract the following data: demographics, history, foreign body retrieved, clinical signs at presentation, management strategy, duration of hospitalization, and morbidity and mortality. There were 10 patients with RFBs over the study period. The annual incidence of this phenomenon was 0...
November 29, 2016: American Journal of Men's Health
https://www.readbyqxmd.com/read/27900327/migrating-fish-bone-piercing-the-common-carotid-artery-thyroid-gland-and-causing-deep-neck-abscess
#10
Hafizah Husna Johari, Bee-Lian Khaw, Zulkifli Yusof, Irfan Mohamad
Foreign body (FB) ingestion is very common in Malaysian population. The most commonly ingested FB is fish bone. Common presenting symptoms include FB sensation, odynophagia and or sharp pricking pain during swallowing. A careful history and physical examination is very important. Despite negative laryngoscopy and rigid esophagoscopy, persistent symptoms warrants further radiographic imaging studies. The FB can migrate extraluminally and involve other important adjacent structures of the neck and along the digestive tract...
November 16, 2016: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/27900276/foreign-body-in-duodenum-mimicking-a-duplication-cyst-on-imaging
#11
Aditya Pratap Singh, Vinay Mathur, Ramesh Tanger, Arun Gupta, Ayush Kumar
Paediatric age group is most vulnerable for the accidental foreign body (FB) ingestion which may go unnoticed. These patients present with symptoms or complications as a result of FB and may mimic other conditions on various investigations. We describe a 9-month old infant who ingested crystal gel ball and presented with vomiting for a month. On radiological imaging it was interpreted as duplication cyst of the duodenum. At operation, crystal gel ball was retrieved. Our case vindicates importance of keeping various possibilities in mind as differential diagnoses during evaluation and management of surgical ailments such as the duplication cyst of duodenum...
November 2016: APSP Journal of Case Reports
https://www.readbyqxmd.com/read/27895878/evaluation-of-visibility-of-foreign-bodies-in-the-maxillofacial-region-comparison-of-computed-tomography-cone-beam-computed-tomography-ultrasound-and-magnetic-resonance-imaging
#12
Solmaz Valizadeh, Hamidreza Pouraliakbar, Leila Kiani, Yaser Safi, Leila Alibakhshi
BACKGROUND: Detection of foreign bodies (FBs) is challenging. Selection of a fast and affordable imaging modality to locate the FB with minimal patient radiation dose is imperative. OBJECTIVES: This study sought to compare four commonly used imaging modalities namely cone beam computed tomography (CBCT), magnetic resonance imaging (MRI), computed tomography (CT), and ultrasound (US) for detection of FBs in the head and neck region. MATERIALS AND METHODS: In this in vitro study, iron, glass, stone, wood, asphalt, and tooth samples measuring 0...
October 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27895378/intravesical-foreign-body-tertiary-care-center-experience-from-pakistan
#13
Hussam Uddin Soomro, Imran Jalbani, Nuzhat Faruqui
Foreign body in bladder is relatively uncommon condition with variable presentations. Literature is limited to case reports and small series from region. Therefore, we planned this study to review our experience regarding intravesical foreign body. This retrospective study was conducted at the Aga Khan University Hospital, Karachi, and comprised 14 patients having intravesical foreign bodies from March 1989 to March 2013. Demographics, presentation, mode of insertion, type of foreign body and management were noted...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27895201/intraorbital-wooden-foreign-body-detected-by-computed-tomography-and-magnetic-resonance-imaging
#14
Alfredo Di Gaeta, Francesco Giurazza, Eugenio Capobianco, Alvaro Diano, Mario Muto
To identify and localize an intraorbital wooden foreign body is often a challenging radiological issue; delayed diagnosis can lead to serious adverse complications. Preliminary radiographic interpretations are often integrated with computed tomography and magnetic resonance, which play a crucial role in reaching the correct definitive diagnosis. We report on a 40 years old male complaining of pain in the right orbit referred to our hospital for evaluation of eyeball pain and double vision with an unclear clinical history...
November 28, 2016: Neuroradiology Journal
https://www.readbyqxmd.com/read/27894434/pediatric-airway-and-esophageal-foreign-bodies
#15
REVIEW
Elizabeth A Berdan, Thomas T Sato
Foreign bodies aspirated into the airway or ingested with retention in the esophagus are common in infants and children. Both can cause life-threatening complications and must be approached with expeditious diagnosis and definitive treatment. Pediatric surgeons should be familiar with diagnosis, treatment, operative management, complications, and outcomes of aerodigestive tract foreign bodies.
February 2017: Surgical Clinics of North America
https://www.readbyqxmd.com/read/27894427/overview-of-wound-healing-and-management
#16
REVIEW
Dylan R Childs, Ananth S Murthy
Wound healing is a highly complex chain of events, and although it may never be possible to eliminate the risk of experiencing a wound, clinicians' armamentarium continues to expand with methods to manage it. The phases of wound healing are the inflammatory phase, the proliferative phase, and the maturation phase. The pathway of healing is determined by characteristics of the wound on initial presentation, and it is vital to select the appropriate method to treat the wound based on its ability to avoid hypoxia, infection, excessive edema, and foreign bodies...
February 2017: Surgical Clinics of North America
https://www.readbyqxmd.com/read/27891384/bioresorbable-scaffolds-current-evidences-in-the-treatment-of-coronary-artery-disease
#17
REVIEW
Bhargav Dave
Percutaneous coronary revascularization strategies have gradually progressed over a period of last few decades. The advent of newer generation drug-eluting stents has significantly improved the outcomes of Percutaneous Coronary Intervention (PCI) by substantially reducing in-stent restenosis and stent thrombosis. However, vascular inflammation, restenosis, thrombosis, and neoatherosclerosis due to the permanent presence of a metallic foreign body within the artery limit their usage in complex Coronary Artery Disease (CAD)...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27891009/a-forgotten-foreign-body-in-bronchus
#18
Sanjivani J Keny, Uday C Kakodkar
No abstract text is available yet for this article.
November 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27890998/foreign-body-in-the-lung-following-dental-procedure
#19
Rajiv Goyal, Pratibha Gogia, Vaibhav Chachra, Kedar Hibare
This is an interesting case report of a foreign body (FB) aspiration in an adult patient. The FB in question was a dental drill, which accidentally went into the airways during a dental procedure. The extraction was technically difficult due to the peripheral location and thin and sharp tip of the FB. The extraction of this FB required a unique innovation through the rigid bronchoscope.
November 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27890112/an-autopsy-case-of-prolonged-asphyxial-death-caused-by-the-impacted-denture-in-the-esophagus
#20
Kazuhisa Funayama, Junko Fujihara, Haruo Takeshita, Hisakazu Takatsuka
A foreign body impacted in the esophagus is not a rare incident among adults or children. In adults, a dental prosthesis is prone to become impacted in the esophagus. The diagnostic difficulty of this often causes a delay in its removal, which can lead to serious complications, including death. This report describes the autopsy case of a man who died of prolonged asphyxiation induced by the delayed removal of an impacted denture, which was misdiagnosed on his first visit notwithstanding that a part of the denture could be seen on X-rays...
November 2016: Legal Medicine
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