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Hepatic iron

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https://www.readbyqxmd.com/read/28332306/impact-of-iatrogenic-iron-overload-on-the-course-of-hepatitis-c-in-dialysis-population-a-plea-for-caution
#1
Guy Rostoker, Nosratola D Vaziri
About 2.5% of the world population, corresponding to about 177 million individuals, are infected by hepatitis C virus (HCV), a small, single-stranded RNA virus. The prevalence of HCV infection among dialysis patients in Japan, Europe, and North America during the 2012 to 2015 period was found to be 8.7% in the DOPPS study. Nosocomial HCV spread in hemodialysis facilities still occurs. Increased hepatic tissue iron has been shown to play a deleterious role in the course of hepatitis C, favor development of fibrosis and cirrhosis and possibly increase the risk of liver cancer in the general population...
March 23, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28317386/hepatoprotective-effect-of-blocking-n-methyl-d-aspartate-receptors-in-male-albino-rats-exposed-to-acute-and-repeated-restraint-stress
#2
Shaimaa Nasr Amin, Ahmed Amro El-Aidi, Maha Zickri, Laila Ahmed Rashed, Sherif Sabry Hassan
Stress affects multiple organs in the body in addition to the brain including the liver. We aimed to assess the effects of blocking N-methyl-D-aspartate (NMDA) glutamate receptors by memantine on the liver in acute and repeated restraint stress. Forty two male albino rats divided into seven groups; control, Acute restraint stress (ARS), ARS+memantine, repeated restraint stress, repeated restraint +memantine and positive control groups. We measured serum iron, zinc, alanine transferase and Aspartame transferase, hepatic malondialdehyde, tumor necrosis factor-alpha (TNF-α), glutathione peroxidase, Superoxide dismutase, metallothionein content, zinc transporter ZRT/IRT-like Protein 14 mRNA expression, hepcidin expression...
March 18, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28306527/investigation-of-the-role-of-%C3%AE-lipoic-acid-on-fatty-acids-profile-some-minerals-zinc-copper-iron-and-antioxidant-activity-against-aluminum-induced-oxidative-stress-in-the-liver-of-male-rats
#3
Zafer Sahin, Ahmet Ozkaya, Okkes Yilmaz, Abdurrauf Yuce, Mehmet Gunes
BACKGROUND: We have investigated the effects of α-lipoic acid (LA), a powerful antioxidant, on the fatty acid (FA) profiles, aluminum accumulation, antioxidant activity and some minerals such as zinc, copper and iron against aluminum chloride (AlCl3)-induced oxidative stress in rat liver. METHODS: Twenty-eight male Wistar rats were divided into four groups as control, LA, AlCl3 and LA+AlCl3. For 30 days, LA was intraperitoneally administrated (50 mg/kg) and AlCl3 was given via orogastric gavage (1600 ppm) every other day...
March 17, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28299304/effects-of-phlebotomy-on-liver-enzymes-and-histology-of-patients-with-nonalcoholic-fatty-liver-disease
#4
Mahsa Khodadoostan, Maryam Zamanidoost, Ahmad Shavakhi, Hosein Sanei, Masood Shahbazi, Mehdi Ahmadian
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD), defined as excessive liver fat deposition and one of end-stage liver disease causes. Increased ferritin levels are associated with insulin resistance and a higher hepatic iron and fat content. Hyperferritinemia has been associated with severity of liver damage in NAFLD. The study aimed to evaluate the effects of phlebotomy on liver enzymes and histology in such patients. MATERIALS AND METHODS: Thirty-two eligible patients who had NAFLD and after 6 months of lifestyle modification still had NAFLD, and whose ferritin serum was above 250 mg/dl, were enrolled in this clinical trial study...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28296163/long-term-safety-and-efficacy-of-deferasirox-in-young-pediatric-patients-with-transfusional-hemosiderosis-results-from-a-5-year-observational-study-entrust
#5
Elliott Vichinsky, Amal El-Beshlawy, Azzam Al Zoebie, Annie Kamdem, Suzanne Koussa, Thirachit Chotsampancharoen, Andreas Bruederle, Geralyn Gilotti, Jackie Han, Mohsen Elalfy
BACKGROUND: Children with red blood cell disorders may receive regular transfusions from an early age and consequently accumulate iron. Adequate iron chelation therapy can prevent organ damage and delayed growth/development. Deferasirox is indicated for treatment of pediatric patients with chronic iron overload due to transfusional hemosiderosis; however, fewer than 10% of patients in the registration studies were aged 2 to less than 6 years. PROCEDURE: Deferasirox, a once-daily oral iron chelator, was evaluated in young pediatric patients with transfusional hemosiderosis during the observational 5-year ENTRUST study...
March 10, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28292647/transfusion-transmitted-infections-in-frequently-transfused-thalassemic-children-living-in-fayoum-governorate-egypt-current-prevalence-and-risk-factors
#6
Zeze Th Atwa, Wafaa Y Abdel Wahed
Regular blood transfusion therapy remains the primary treatment in thalassemia major (TM). Transfusion-transmitted infections (TTIs) and iron overload are considered to be the major drawbacks of this therapy. This cross-sectional study aimed to update the prevalence of the hepatitis C virus (HCV) antibody, PCR-confirmed HCV, hepatitis B surface antigen (HBsAg), and human immunodeficiency virus (HIV) antibody among TM children. Clinical and epidemiological factors that can affect HCV infection prevalence rate were studied...
March 11, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28283693/genetically-engineered-escherichia-coli-nissle-1917-synbiotic-counters-fructose-induced-metabolic-syndrome-and-iron-deficiency
#7
Archana Somabhai Chaudhari, Ruma Raghuvanshi, G Naresh Kumar
Consumption of fructose leads to metabolic syndrome, but it is also known to increase iron absorption. Present study investigates the effect of genetically modified Escherichia coli Nissle 1917 (EcN) synbiotic along with fructose on non-heme iron absorption. Charles foster rats weighing 150-200 g were fed with iron-deficient diet for 2 months. Probiotic treatment of EcN (pqq) and EcN (pqq-glf-mtlK) was given once per week, 10(9) cells after 2 months with fructose in drinking water. Iron levels, blood, and liver parameters for oxidative stress, hyperglycemia, and dyslipidemia were estimated...
March 10, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28273797/partially%C3%A2-hydrolyzed%C3%A2-guar%C3%A2-gum%C3%A2-increases%C3%A2-ferroportin%C3%A2-expression%C3%A2-in%C3%A2-the%C3%A2-colon%C3%A2-of%C3%A2-anemic%C3%A2-growing%C3%A2-rats
#8
Luciana Carvalho, Débora Brait, Márcia Vaz, Pablo Lollo, Priscila Morato, Silvia Oesterreich, Jorge Raposo, Karine Freitas
Studies have reported a positive effect of prebiotics on the bioavailability of iron. This study evaluated the effect of partially hydrolyzed guar gum (PHGG) on iron absorption mechanisms in anemic rats. Male Wistar rats were fed 75g American Institute of Nutrition Rodent Diets for growth, pregnancy and lactation (AIN93-G) without iron for three weeks in order to induce iron deficiency anemia. Then they were fed a control diet (n = 12; without fiber) or a diet with 7.5% of PHGG (n = 12), both without iron. Food intake, body growth and the feed efficiency coefficient (FEC) were measured...
March 3, 2017: Nutrients
https://www.readbyqxmd.com/read/28273650/bioanalysis-of-pseudomonas-aeruginosa-alkyl-quinolone-signalling-molecules-in-infected-mouse-tissue-using-lc-ms-ms-and-its-application-to-a-pharmacodynamic-evaluation-of-mvfr-inhibition
#9
Paul Turnpenny, Anthony Padfield, Patrick Barton, Joanne Teague, Laurence G Rahme, Michael J Pucci, Robert Zahler, Aileen Rubio
Alkyl quinolone molecules 2-heptyl-4-quinolone (HHQ) and 2-heptyl-3-hydroxy-4(1H)-quinolone (PQS) are important quorum sensing signals, which play a mediatory role in the pathogenesis of acute and chronic Pseudomonas aeruginosa infection. A targeted approach inhibiting the bacterial 'multiple virulence factor regulon' (MvfR) protein complex, offers the possibility to block the synthesis of MvfR-dependant signal molecules. Here, a high throughput bioanalytical method was developed using LC-MS/MS detection for the selective determination of HHQ and PQS in mouse tissue homogenate, over a sensitive range of 1-5000 and 10-5000pg/mL, respectively...
February 28, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28267532/r2-relaxometry-of-the-pancreas-in-patients-with-human-hemochromatosis-protein-associated-hereditary-hemochromatosis
#10
B Henninger, S Rauch, H Zoller, M Plaikner, W Jaschke, C Kremser
PURPOSE: To evaluate pancreatic iron in patients with human hemochromatosis protein associated hereditary hemochromatosis (HHC) using R2* relaxometry. MATERIALS AND METHODS: 81 patients (58 male, 23 female; median age 49.5, range 10-81 years) with HHC were retrospectively studied. All underwent 1.5T magnetic resonance imaging (MRI) of the abdomen. A fat-saturated multi-gradient echo sequence with 12 echoes (TR=200ms; TE-initial 0.99ms; Delta-TE 1.41ms; 12 echoes; flip-angle: 20°) was used for the R2* quantification of the liver and the pancreas...
April 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28250659/antidiabetic-effects-of-aqueous-and-dichloromethane-methanol-stem-bark-extracts-of-pterocarpus-soyauxii-taub-papilionaceae-on-streptozotocin-induced-diabetic-rats
#11
Marie Claire Tchamadeu, Paul Désiré Djomeni Dzeufiet, Nelly Blaes, Jean-Pierre Girolami, Pierre Kamtchouing, Théophile Dimo
AIM OF THE STUDY: The aim is to evaluate the hypoglycemic and antidiabetic effects of aqueous and CH2Cl2/CH3OH stem bark extracts of Pterocarpus soyauxii Taub in normal and diabetic rats. MATERIALS AND METHODS: Streptozotocin (STZ)-induced diabetic and normal adult Wistar rats were orally administered with aqueous and CH2Cl2/CH3OH plant extracts of P. soyauxii at various doses (38-300 mg/kg) in a single administration. In addition, STZ-induced diabetic rats received prolonged daily administration for 14 days...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28246565/diphenhydramine-as-a-cause-of-drug-induced-liver-injury
#12
Yunseok Namn, Yecheskel Schneider, Isabelle H Cui, Arun Jesudian
Drug-induced liver injury (DILI) is the most common cause of acute liver failure in the Unites States and accounts for 10% of acute hepatitis cases. We report the only known case of diphenhydramine-induced acute liver injury in the absence of concomitant medications. A 28-year-old man with history of 13/14-chromosomal translocation presented with fevers, vomiting, and jaundice. Aspartate-aminotransferase and alanine-aminotransferase levels peaked above 20,000 IU/L and 5,000 IU/L, respectively. He developed coagulopathy but without altered mental status...
2017: Case Reports in Hepatology
https://www.readbyqxmd.com/read/28245425/intra-arterial-delivery-of-superparamagnetic-iron-oxide-nanoshell-and-polyvinyl-alcohol-based-chemoembolization-system-for-the-treatment-of-liver-tumor
#13
Qi Liang, Yi-Xiang Wang, Jin-Song Ding, Wei He, Ling-Ling Deng, Na Li, Yun-Jie Liao, Zhen Li, Bin Ye, Wei Wang
A superparamagnetic iron oxide (SPIO) nanoshell and polyvinyl alcohol (PVA) based chemoembolization system for anti-cancer drug doxorubicin (DOX) delivery has previously been presented. We have also previously confirmed the feasibility and safety of this multifunctional system for carrying both DOX and SPIO nanoparticles in vitro. However, the pharmacokinetic and the therapeutic efficacy of this novel drug-delivery system in vivo is not yet clear, and as such was the subject of this study. A rabbit liver tumor model was utilized, whereby the tumors were targeted by SPIO/DOX/PVA composite infused via a catheter into the hepatic arteries which supplying blood to the tumor...
January 2017: Discovery Medicine
https://www.readbyqxmd.com/read/28240317/non-invasive-mri-biomarkers-for-the-early-assessment-of-iron-overload-in-a-humanized-mouse-model-of-%C3%AE-thalassemia
#14
Laurence H Jackson, Evangelia Vlachodimitropoulou, Panicos Shangaris, Thomas A Roberts, Thomas M Ryan, Adrienne E Campbell-Washburn, Anna L David, John B Porter, Mark F Lythgoe, Daniel J Stuckey
β-thalassemia (βT) is a genetic blood disorder causing profound and life threatening anemia. Current clinical management of βT is a lifelong dependence on regular blood transfusions, a consequence of which is systemic iron overload leading to acute heart failure. Recent developments in gene and chelation therapy give hope of better prognosis for patients, but successful translation to clinical practice is hindered by the lack of thorough preclinical testing using representative animal models and clinically relevant quantitative biomarkers...
February 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28237298/assessment-of-liver-fibrosis-using-t1-mapping-on-gd-eob-dtpa-enhanced-magnetic-resonance
#15
Ruo Fan Sheng, He Qing Wang, Li Yang, Kai Pu Jin, Yan Hong Xie, Cai Xia Fu, Meng Su Zeng
BACKGROUND: Few studies have investigated the value of Gd-EOB-DTPA-enhanced T1 mapping in exact fibrosis staging, especially its correlation with hepatic molecular transporters. AIMS: To investigate the diagnostic value of Gd-EOB-DTPA-enhanced T1 mapping in staging liver fibrosis and its relationship with hepatic molecular transporters. METHODS: Thirty rats were divided into the carbon tetrachloride-induced fibrosis groups and a control group...
February 22, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28231420/serum-ferritin-concentration-predicts-hepatic-fibrosis-better-than-hepatic-iron-concentration-in-human-hfe-hemochromatosis
#16
Marnie J Wood, Darrell H G Crawford, Leesa F Wockner, Lawrie W Powell, Grant A Ramm
BACKGROUND & AIMS: Ferritin is purported to have proinflammatory and profibrogenic effects on hepatic stellate cells. Thus, rather than acting as a passive indicator of hepatic iron concentration (HIC) in hemochromatosis, ferritin may directly influence fibrosis. This study evaluated whether serum ferritin is a better predictor of hepatic fibrosis compared to variables previously associated with increased fibrosis risk in hemochromatosis. METHODS: We identified 291 C282Y HFE-homozygous patients who had undergone liver biopsy for histological fibrosis staging and measurement of HIC...
February 23, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28228829/hepatic-iron-storage-is-related-to-body-adiposity-and-hepatic-inflammation
#17
Chan Yoon Park, Jayong Chung, Kyung-Ok Koo, Min Soo Kim, Sung Nim Han
BACKGROUND: Obesity has been reported to be associated with iron deficiency. However, few studies have investigated iron status in low adiposity. To investigate whether body adiposity was associated with altered hepatic iron status, we compared liver iron levels and markers involved in inflammation and iron absorption in obese, control, and mildly calorie restricted mice. METHODS: Seven week old C57BL/6 mice were fed control (10% kcal fat, Control) or high fat (60% kcal fat, HFD) diets, or reduced amount of control diet to achieve 15% calorie restriction (CR) for 16 weeks...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28225576/3d-multiecho-dixon-for-the-evaluation-of-hepatic-iron-and-fat-in-a-clinical-setting
#18
Benjamin Henninger, Heinz Zoller, Stephan Kannengiesser, Xiaodong Zhong, Werner Jaschke, Christian Kremser
PURPOSE: To prospectively evaluate a new 3D-multiecho-Dixon (3D-ME-Dixon) sequence for the quantification of hepatic iron and fat in a clinical setting. MATERIALS AND METHODS: In all, 120 patients underwent 1.5T magnetic resonance imaging of the liver between December 2013 and June 2015 including the following three sequences: 3D-ME-Dixon with inline calculation of R2* and proton-density fat-fraction (PDFF) maps, single-voxel-spectroscopy (SVS), 2D multigradient-echo sequence (2D-ME-GRE)...
February 22, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28224171/assessment-of-liver-iron-overload-by-3%C3%A2-t-mri
#19
A Paisant, A Boulic, E Bardou-Jacquet, E Bannier, G d'Assignies, F Lainé, B Turlin, Y Gandon
PURPOSE: To evaluate the performance and limitations of the signal intensity ratio method for quantifying liver iron overload at 3 T. METHODS: Institutional review board approval and written informed consent from all participants were obtained. One hundred and five patients were included prospectively. All patients underwent a liver biopsy with biochemical assessment of hepatic iron concentration and a 3 T MRI scan with 5 breath-hold single-echo gradient-echo sequences...
February 21, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28219768/copper-therapy-reduces-intravascular-hemolysis-and-derepresses-ferroportin-in-mice-with-mosaic-mutation-atp7a-mo-ms-an-implication-for-copper-mediated-regulation-of-the-slc40a1-gene-expression
#20
Małgorzata Lenartowicz, Rafał R Starzyński, Aneta Jończy, Robert Staroń, Justyna Antoniuk, Wojciech Krzeptowski, Paweł Grzmil, Aleksandra Bednarz, Olga Pierzchała, Mateusz Ogórek, Zenon Rajfur, Zbigniew Baster, Paweł Lipiński
Mosaic mutant mice displaying functional dysfunction of Atp7a copper transporter (the Menkes ATPase) are an established animal model of Menkes disease and constitute a convenient tool for investigating connections between copper and iron metabolisms. This model allows to explore changes in iron metabolism in suckling mutant mice suffering from systemic copper deficiency as well as in young and adult ones undergone copper therapy, which reduces lethal effect of the Atp7a gene mutation. Our recent study demonstrated that 14-day-old mosaic mutant males display blood cell abnormalities associated with intravascular hemolysis, and show disturbances in the functioning of the hepcidin-ferroportin regulatory axis, which controls systemic iron homeostasis...
February 17, 2017: Biochimica et Biophysica Acta
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