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https://www.readbyqxmd.com/read/29677684/universal-influenza-virus-vaccines-and-therapeutics-where-do-we-stand-with-influenza-b-virus
#1
REVIEW
Jessica Tan, Guha Asthagiri Arunkumar, Florian Krammer
The development of a broadly protective or universal influenza virus vaccine is currently a public health priority worldwide. The vast majority of these efforts is exclusively focused on influenza A viruses. While influenza A viruses cause the majority of all influenza cases worldwide, influenza B viruses should not be ignored. Approximately 25% of all influenza cases are caused by influenza B viruses which circulate as two distinct B/Victoria/2/87-like and B/Yamagata/16/88-like lineages. In contrast to popular belief, influenza B cases frequently cause significant morbidity and mortality, especially in children...
April 17, 2018: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29677139/musculoskeletal-model-development-of-the-elbow-joint-with-an-experimental-evaluation
#2
Munsur Rahman, Mohsen Sharifi Renani, Akin Cil, Antonis P Stylianou
A dynamic musculoskeletal model of the elbow joint in which muscle, ligament, and articular surface contact forces are predicted concurrently would be an ideal tool for patient-specific preoperative planning, computer-aided surgery, and rehabilitation. Existing musculoskeletal elbow joint models have limited clinical applicability because of idealizing the elbow as a mechanical hinge joint or ignoring important soft tissue (e.g., cartilage) contributions. The purpose of this study was to develop a subject-specific anatomically correct musculoskeletal elbow joint model and evaluate it based on experimental kinematics and muscle electromyography measurements...
April 20, 2018: Bioengineering
https://www.readbyqxmd.com/read/29676877/assessment-and-management-of-urinary-incontinence-in-women
#3
Ellie Stewart
Urinary incontinence is a common and usually hidden issue that can affect women of all ages. It is often ignored by the patient because of their misconception that incontinence is an inevitable consequence of ageing and their low expectations of successful treatment. There are various types of incontinence, with symptoms that can significantly affect patients' quality of life. This article aims to enhance nurses' understanding of the types of urinary incontinence affecting women, associated risk factors and continence assessment, as well as the initial investigations and conservative treatments that can be instigated by general nurses...
April 20, 2018: Nursing Standard
https://www.readbyqxmd.com/read/29676567/biomolecular-corona-dictates-a%C3%AE-fibrillation-process
#4
Alireza Lotfabadi, Mohammad Javad Hajipour, Hossein Derakhshankhah, Afshin Peirovi, Samaneh Saffar, Elnaz Shams, Elnaz Fatemi, Ebrahim Barzegari, Sajad Sarvari, Faezeh Moakedi, Maryam Ferdousi, Fatemeh Atyabi, Ali Akbar Saboury, Rassoul Dinarvand
Amyloid beta (Aβ), which forms toxic oligomers and fibrils in brain tissues of patients with Alzheimer's disease, is broadly used as a model protein to probe the effect of nanoparticles (NPs) on oligomerization and fibrillation process. However, majority of the reports in the field, ignored the effect of biomolecular corona on the fibrillogenesis of the Aβ proteins. Biomolecular corona, which is a layer composed of various types of biomolecules that covers surface of NPs upon their interaction with biological fluids, determines the biological fates of NPs...
April 20, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29675726/role-of-rotifers-in-microzooplankton-community-in-a-large-monsoonal-estuary-cochin-backwaters-along-the-west-coast-of-india
#5
A Anjusha, R Jyothibabu, L Jagadeesan, N Arunpandi
The distribution ecology of microzooplankton in the Kochi (Cochin) backwaters has been presented. Emphasis has been given to the micro-rotifers present in the environment, considering they were a hitherto ignored component of the microzooplankton in the past studies. Three seasonal samplings were carried out at six locations along the salinity gradients in the Kochi backwaters during the Pre-Monsoon (March), Southwest Monsoon (August), and Northeast Monsoon (December). A total of 48 species of microzooplankton were recorded, of which 35 were ciliates, 10 were rotifers, and 3 were heterotrophic dinoflagellates...
April 19, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29675706/audiomotor-integration-of-angry-and-happy-prosodies
#6
Sélim Yahia Coll, Sascha Frühholz, Didier Grandjean
Different parts of our brain code the perceptual features and actions related to an object, causing a binding problem: how does the brain discriminate the information of a particular event from the features of other events? Hommel (1998) suggested the event file concept: an episodic memory trace binding perceptual and motor information pertaining to an object. By adapting Hommel's paradigm to emotional faces in a previous study (Coll & Grandjean, 2016), we demonstrated that emotion could take part in an event file with motor responses...
April 19, 2018: Psychological Research
https://www.readbyqxmd.com/read/29675314/first-principles-calculations-of-raman-vibrational-modes-in-the-fingerprint-region-for-connective-tissue
#7
E T Sato, H Martinho
Vibrational spectroscopy has been widely employed to unravel the physical-chemical properties of biological systems. Due to its high sensitivity to monitoring real time " in situ " changes, Raman spectroscopy has been successfully employed, e.g., in biomedicine, metabolomics, and biomedical engineering. The interpretation of Raman spectra in these cases is based on the isolated macromolecules constituent vibrational assignment. Due to this, probing the anharmonic or the mutual interactions among specific moieties/side chains is a challenge...
April 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29675218/the-self-disproportionation-of-enantiomers-sde-a-menace-or-an-opportunity
#8
REVIEW
Jianlin Han, Osamu Kitagawa, Alicja Wzorek, Karel D Klika, Vadim A Soloshonok
Herein we report on the well-documented, yet not widely known, phenomenon of the self-disproportionation of enantiomers (SDE): the spontaneous fractionation of scalemic material into enantioenriched and -depleted fractions when any physicochemical process is applied. The SDE has implications ranging from the origins of prebiotic homochirality to unconventional enantiopurification methods, though the risks of altering the enantiomeric excess (ee) unintentionally, regrettably, remain greatly unappreciated. While recrystallization is well known as an SDE process, occurrences of the SDE in other processes are much less recognized, e...
February 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/29675047/menstrual-hygiene-management-and-waste-disposal-practices-and-challenges-faced-by-girls-women-of-developing-countries
#9
REVIEW
Rajanbir Kaur, Kanwaljit Kaur, Rajinder Kaur
Menstruation and menstrual practices still face many social, cultural, and religious restrictions which are a big barrier in the path of menstrual hygiene management. In many parts of the country especially in rural areas girls are not prepared and aware about menstruation so they face many difficulties and challenges at home, schools, and work places. While reviewing literature, we found that little, inaccurate, or incomplete knowledge about menstruation is a great hindrance in the path of personal and menstrual hygiene management...
2018: Journal of Environmental and Public Health
https://www.readbyqxmd.com/read/29674311/-wish-you-were-here-examining-characteristics-outcomes-and-statistical-solutions-for-missing-cases-in-web-based-psychotherapeutic-trials
#10
Eyal Karin, Blake F Dear, Gillian Z Heller, Monique F Crane, Nickolai Titov
BACKGROUND: Missing cases following treatment are common in Web-based psychotherapy trials. Without the ability to directly measure and evaluate the outcomes for missing cases, the ability to measure and evaluate the effects of treatment is challenging. Although common, little is known about the characteristics of Web-based psychotherapy participants who present as missing cases, their likely clinical outcomes, or the suitability of different statistical assumptions that can characterize missing cases...
April 19, 2018: JMIR Mental Health
https://www.readbyqxmd.com/read/29673860/the-endogenous-circadian-clock-programs-animals-to-eat-at-certain-times-of-the-24-hour-day-what-if-we-ignore-the-clock
#11
Peng Jiang, Fred W Turek
The discovery of the molecular mechanisms underlying the circadian clock, which functions in virtually every cell throughout the body to coordinate biological processes to anticipate and better adapt to daily rhythmic changes in the environment, is one of the major biomedical breakthroughs in the 20th century. Twenty years after this breakthrough, the biomedical community is now at a new frontier to incorporate the circadian clock mechanisms into many areas of biomedical research, as studies continue to reveal an important role of the circadian clock in a wide range of biological functions and diseases...
April 16, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29673746/-paget-s-disease-of-ectopic-breast
#12
M-H Jegou, E Lorier-Roy
BACKGROUND: Paget's disease of the breast is rare, even more so when it occurs in a supernumerary breast since diagnosis is delayed due to lack of exploration and ignorance of the pathology of ectopic breast. Based on an original clinical case, we provide a clinical update concerning ectopic breast and ectopic carcinoma, including Paget's disease. PATIENTS AND METHODS: A 44-year-old woman had complained of pain in the area of her supernumerary breast for several months...
April 16, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29673154/accounting-for-space-quantification-of-cell-to-cell-transmission-kinetics-using-virus-dynamics-models
#13
Peter Kumberger, Karina Durso-Cain, Susan L Uprichard, Harel Dahari, Frederik Graw
Mathematical models based on ordinary differential equations (ODE) that describe the population dynamics of viruses and infected cells have been an essential tool to characterize and quantify viral infection dynamics. Although an important aspect of viral infection is the dynamics of viral spread, which includes transmission by cell-free virions and direct cell-to-cell transmission, models used so far ignored cell-to-cell transmission completely, or accounted for this process by simple mass-action kinetics between infected and uninfected cells...
April 17, 2018: Viruses
https://www.readbyqxmd.com/read/29673078/crispr-cas9-mediated-gfp-knock-in-at-the-map1lc3b-locus-in-293ft-cells-is-better-for-bona-fide-monitoring-cellular-autophagy
#14
Zhiqiang Wu, Jinlin Zhao, Minghan Qiu, Zeyun Mi, Maobin Meng, Yu Guo, Hui Wang, Zhiyong Yuan
Accurately identifying and quantifying cellular autophagy is very important as the significance of autophagy in physiological and pathological processes becomes increasingly evident. Ectopically expressed fluorescent-tagged microtubule-associated protein light chain 3B (MAP1LC3B, LC3) is the most widely used reporter for monitoring autophagy activity thus far. However, this approach ignored the influence of constitutively overexpressed LC3 on autophagy itself and autophagy-related processes and its accuracy in indicating autophagy is questionable...
April 19, 2018: Biotechnology Journal
https://www.readbyqxmd.com/read/29672448/a-dyadic-analysis-of-siblings-relationship-quality-behavioural-responses-and-pain-experiences-during-experimental-pain
#15
Meghan G Schinkel, Christine T Chambers, Penny Corkum, Sophie Jacques
Research on family factors in paediatric pain has primarily focused on parents; the role of siblings has been largely ignored. This study examined whether sibling relationship quality was related to siblings' behaviours during experimental pain, and whether the behaviours of an observing sibling were related to children's pain outcomes. Ninety-two sibling dyads between 8-12 years old completed both observational and questionnaire measures of sibling relationship quality. Children took turns completing the cold pressor task (CPT) in a counterbalanced order with their sibling present...
April 16, 2018: Pain
https://www.readbyqxmd.com/read/29672243/sovereignty-and-social-justice-how-the-concepts-affect-federal-american-indian-policy-and-american-indian-health
#16
Donalee Unal
The health disparities that are prevalent among American Indian and Alaska Native (AI/AN) communities are connected to the ideology of sovereignty and often ignored in social work and public health literature. Therefore, the purpose of this paper is to examine the health outcomes of American Indians from the time of contact with European settlers to the present through the ideology of sovereignty and federal government AI health policy. The foundation for the health outcomes of AIs and the governmental policies affecting them lie in the ideology of tribal sovereignty...
April 19, 2018: Social Work in Public Health
https://www.readbyqxmd.com/read/29672048/propagators-for-the-time-dependent-kohn-sham-equations-multistep-runge-kutta-exponential-runge-kutta-and-commutator-free-magnus-methods
#17
Adrián Gómez Pueyo, Miguel A L Marques, Angel Rubio, Alberto Castro
We examine various integration schemes for the time-dependent Kohn-Sham equations. Contrary to the time-dependent Schrödinger's equation, this set of equations is non-linear, due to the dependence of the Hamiltonian on the electronic density. We discuss some of their exact properties, and in particular their symplectic structure. Four different families of propagators are considered, specifically the linear multistep, Runge-Kutta, exponential Runge-Kutta, and the commutator-free Magnus schemes. These have been chosen because they have been largely ignored in the past for time-dependent electronic structure calculations...
April 19, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29671400/measuring-phenotype-phenotype-similarity-through-the-interactome
#18
Jiajie Peng, Weiwei Hui, Xuequn Shang
BACKGROUND: Recently, measuring phenotype similarity began to play an important role in disease diagnosis. Researchers have begun to pay attention to develop phenotype similarity measurement. However, existing methods ignore the interactions between phenotype-associated proteins, which may lead to inaccurate phenotype similarity. RESULTS: We proposed a network-based method PhenoNet to calculate the similarity between phenotypes. We localized phenotypes in the network and calculated the similarity between phenotype-associated modules by modeling both the inter- and intra-similarity...
April 11, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29671160/cardiac-metaplasia-follow-treat-or-ignore
#19
REVIEW
Stuart J Spechler
Over the past two decades, evidence has accumulated to challenge the traditional view that cardiac mucosa, which is comprised exclusively of mucus glands, is the normal lining of the most proximal portion of the stomach (the gastric cardia). There is now considerable evidence to suggest that cardiac mucosa develops as a GERD-induced, squamous-to-columnar esophageal metaplasia in some, if not all, cases. Although cardiac mucosa lacks the goblet cells commonly required for a histologic diagnosis of intestinal metaplasia, cardiac mucosa has many molecular features of an intestinal-type mucosa, and appears to be the precursor of intestinal metaplasia with goblet cells...
April 18, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29671153/novel-method-for-superposing-3d-digital-models-for-monitoring-orthodontic-tooth-movement
#20
Falko Schmidt, Fatih Kilic, Neltje Emma Piro, Martin Eberhard Geiger, Bernd Georg Lapatki
Quantitative three-dimensional analysis of orthodontic tooth movement (OTM) is possible by superposition of digital jaw models made at different times during treatment. Conventional methods rely on surface alignment at palatal soft-tissue areas, which is applicable to the maxilla only. We introduce two novel numerical methods applicable to both maxilla and mandible. The OTM from the initial phase of multi-bracket appliance treatment of ten pairs of maxillary models were evaluated and compared with four conventional methods...
April 18, 2018: Annals of Biomedical Engineering
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