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https://www.readbyqxmd.com/read/29458085/the-effect-of-surface-charge-and-ph-on-the-physiological-behaviour-of-cobalt-copper-manganese-antimony-zinc-and-titanium-oxide-nanoparticles-in-vitro
#1
Tiina Titma
The precise knowledge on various interactions of metal nanoparticles (NP) in a living organism is scarce. It is expected that metals can bind to nucleic acids, peptides and proteins (e.g. enzymes), and modify the functioning of vital cellular compartments after entering the organism. The predictive factors for quantitative nanostructure-activity relationship (QNAR) analysis could enhance efficient and harmless usage of nanoparticles (NPs) in the industry as well in the medicine. The studies value the composition of the NP corona determined by time, temperature and source of protein which has been found to implicate the physiological behaviour of NPs...
February 16, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29456905/a-comprehensive-review-of-the-sternal-foramina-and-its-clinical-significance
#2
REVIEW
Paul J Choi, Joe Iwanaga, R Shane Tubbs
A sternal foramen (SF), which arises from the incomplete fusion of the cartilaginous neonatal sternum, is a relatively common anatomical variation found in 2.5% to 13.8 % of all individuals. SFs are usually located at the lower third of the sternal body and their average diameter is 6.5 mm. An SF is subclinical; however, its close proximity to the thoracic organs, i.e., the heart and lungs, entails a risk of serious complications from blinded sternal interventions. Moreover, its presence can lead to misinterpretation of radiological and postmortem findings...
December 8, 2017: Curēus
https://www.readbyqxmd.com/read/29456622/does-the-oncology-community-have-a-rejection-bias-when-it-comes-to-repurposed-drugs
#3
EDITORIAL
Bishal Gyawali, Pan Pantziarka, Sergio Crispino, Gauthier Bouche
Among the various measures proposed to combat the challenge of financial toxicity in cancer care, an important strategy is the use of lower-priced drugs instead of expensive alternatives. However, the oncology community seems to either ignore or more readily reject cheaper drugs in cancer care compared to more expensive alternatives. In this commentary, we present three examples of lower-priced drugs rejected or ignored by the oncology community and contrast this with three expensive drugs where persistent optimism remained despite negative clinical trial results...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29456403/severe-abdominal-complaints-after-technical-successful-endovascular-treatment-of-chronic-splanchnic-ischemia
#4
Claire A J I Leenarts, Mark J F Haagmans, Lee H Bouwman, Cornelis J J M Sikkink
Reperfusion syndrome (RS) after revascularization of an arterial occlusion of the lower leg is a well-known complication. RS after splanchnic revascularization, however, is an infrequent and less-known phenomenon. We present a patient with persisting abdominal complaints after revascularization of the celiac trunk and superior mesenteric artery suggesting reocclusion. Although computed tomography angiography showed patent splanchnic arteries, an impressive hyperperfusion state of liver and spleen was visualized...
January 2018: Journal of Natural Science, Biology, and Medicine
https://www.readbyqxmd.com/read/29456256/clustering-the-orion-b-giant-molecular-cloud-based-on-its-molecular-emission
#5
Emeric Bron, Chloé Daudon, Jérôme Pety, François Levrier, Maryvonne Gerin, Pierre Gratier, Jan H Orkisz, Viviana Guzman, Sébastien Bardeau, Javier R Goicoechea, Harvey Liszt, Karin Öberg, Nicolas Peretto, Albrecht Sievers, Pascal Tremblin
Context: Previous attempts at segmenting molecular line maps of molecular clouds have focused on using position-position-velocity data cubes of a single molecular line to separate the spatial components of the cloud. In contrast, wide field spectral imaging over a large spectral bandwidth in the (sub)mm domain now allows one to combine multiple molecular tracers to understand the different physical and chemical phases that constitute giant molecular clouds (GMCs). Aims: We aim at using multiple tracers (sensitive to different physical processes and conditions) to segment a molecular cloud into physically/chemically similar regions (rather than spatially connected components), thus disentangling the different physical/chemical phases present in the cloud...
February 2018: Astronomy and Astrophysics
https://www.readbyqxmd.com/read/29456140/visual-selective-attention-in-mice
#6
Lupeng Wang, Richard J Krauzlis
Visual selective attention is a fundamental cognitive ability that allows us to process relevant visual stimuli while ignoring irrelevant distracters and has been extensively studied in human and non-human primate subjects. Mice have emerged as a powerful animal model for studying aspects of the visual system but have not yet been shown to exhibit visual selective attention. Differences in the organization of the visual systems of primates and mice raise the possibility that selective visual attention might not be present in mice, at least not in the forms that are well established in primates...
February 8, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29455752/imagining-class-a-study-into-material-social-class-position-subjective-identification-and-voting-behavior-across-europe
#7
Lorenzo D'Hooge, Peter Achterberg, Tim Reeskens
The traditional approach to class voting has largely ignored the question whether material class positions coincide with subjective class identification. Following Sosnaud et al. (2013), this study evaluates party preferences when Europeans' material and subjective social class do not coincide. Seminal studies on voting behavior have suggested that members of lower classes are more likely to vote for the economic left and cultural right and that higher classes demonstrate the opposite pattern. Yet, these studies have on the one hand overlooked the possibility that there is a mismatch between the material class people can be classified in and the class they think they are part of, and on the other hand the consequences of this discordant class identification on voting behavior...
February 2018: Social Science Research
https://www.readbyqxmd.com/read/29455751/varieties-of-political-support-in-emerging-democracies-a-cross-national-analysis
#8
Gabriel Katz, Ines Levin
Political support is a multidimensional construct encompassing evaluations of political leaders and institutions (specific support) as well as adherence to basic regime principles (diffuse support). Scholars have traditionally assumed that diffuse and specific support are driven by different forces and evolve largely independently. Prior empirical work, however, has struggled to untangle the two support dimensions and focused predominantly on cross-national differences, ignoring their dynamics. This paper develops an analytical and empirical approach to examine the levels and dynamic interplay of both support dimensions and estimate their determinants, applying it to South American democracies between 1996 and 2015...
February 2018: Social Science Research
https://www.readbyqxmd.com/read/29455739/general-population-estimates-of-the-association-between-college-experience-and-the-odds-of-forced-intercourse
#9
William George Axinn, Maura Elaine Bardos, Brady Thomas West
Sexual assault on college campuses is a pervasive problem, recently receiving increased scientific and policy attention. However, the high focus on college student experience ignores general population prevalence, trends, and differences between those with college experience and those without. We analyze measures from the National Survey of Family Growth (NSFG) to provide a general population view of experiences with forced intercourse. Forced intercourse is a common experience in the U.S. population, has remained stable in recent years, and varies greatly by gender, age and race...
February 2018: Social Science Research
https://www.readbyqxmd.com/read/29455628/ng%C3%A4-whak%C3%A4-whitinga-standing-at-the-crossroads-how-m%C3%A4-ori-understand-what-western-psychiatry-calls-schizophrenia
#10
Melissa Taitimu, John Read, Tracey McIntosh
This project explored how Māori understand experiences commonly labelled "schizophrenic" or "psychotic". Semi-structured interviews were conducted with 57 Māori participants who had either personal experiences labelled as "psychosis" or "schizophrenia", or who work with people with such experiences; including tangata whaiora (users of mental health services), tohunga (traditional healers), kaumatua/kuia (elders), Māori clinicians, cultural support workers and students...
January 1, 2018: Transcultural Psychiatry
https://www.readbyqxmd.com/read/29455092/internet-pseudoscience-testing-opioid-containing-formulations-with-tampering-potential
#11
Jennifer P Pascali, Paolo Fais, Fabio Vaiano, Nicola Pigaiani, Stefano D'Errico, Sandra Furlanetto, Diego Palumbo, Elisabetta Bertol
Drug tampering practices, with the aim to increase availability of drug delivery and/or enhance drug effects, are accessible on Internet and are practiced by some portion of recreational drug users. Not rarely, recreational misuse may result in toxic and even fatal results. The aim of the present study was to assess the tampering risk of medicaments containing different formulations of an opioid in combination with paracetamol or dexketoprofen, following the procedures reported in dedicated forums on the web...
February 10, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29454751/strain-dependent-variation-in-acute-ischemic-muscle-injury
#12
Cameron A Schmidt, Adam J Amorese, Terence E Ryan, Emma J Goldberg, Michael D Tarpey, Thomas D Green, Reema R Karnekar, Dean J Yamaguchi, Espen E Spangenburg, Joseph M McClung
Limited efficacy of clinical interventions for peripheral arterial disease (PAD) necessitates a better understanding of the environmental and genetic determinants of tissue pathology. Existing research has largely ignored the early skeletal muscle injury response during hindlimb ischemia (HLI). We compared the hindlimb muscle response, following six hours of ischemia, in two mouse strains that differ dramatically in their post-ischemic extended recovery: C57BL/6J and BALB/cJ. Perfusion, measured by laser Doppler and normalized to the control limb, differed only slightly between strains following HLI (<12% across all measures)...
February 15, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29453697/the-sacral-autonomic-outflow-is-parasympathetic-langley-got-it-right
#13
REVIEW
John P Horn
A recent developmental study of gene expression by Espinosa-Medina, Brunet and colleagues sparked controversy by asserting a revised nomenclature for divisions of the autonomic motor system. Should we re-classify the sacral autonomic outflow as sympathetic, as now suggested, or does it rightly belong to the parasympathetic system, as defined by Langley nearly 100 years ago? Arguments for rejecting Espinosa-Medina, Brunet et al.'s scheme subsequently appeared in e-letters and brief reviews. A more recent commentary in this journal by Brunet and colleagues responded to these criticisms by labeling Langley's scheme as a historical myth perpetuated by ignorance...
February 16, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/29452100/a-new-noninvasive-method-of-measuring-impaired-pulmonary-gas-exchange-in-lung-disease-an-outpatient-study
#14
John B West, Daniel R Crouch, Janelle M Fine, Dipen Makadia, Daniel L Wang, G Kim Prisk
BACKGROUND: It would be valuable to have a noninvasive method of measuring impaired pulmonary gas exchange in patients with lung disease and so reduce the need for repeated arterial punctures. Here we report the results of using a new test in a group of outpatients attending a pulmonary clinic. METHODS: Inspired and expired P O2 and P CO2 are continually measured by small, rapidly responding analyzers. The arterial P O2 is calculated from the oximeter Sp O2 and the oxygen dissociation curve...
February 13, 2018: Chest
https://www.readbyqxmd.com/read/29451713/glucose-effectiveness-is-a-critical-pathogenic-factor-leading-to-the-emergence-of-glucose-intolerance-and-type-2-diabetes-mellitus-an-ignored-hypothesis
#15
F P Alford, J E Henriksen, C Rantzau, H Beck-Nielsen
BACKGROUND: Although the ability of glucose to mediate its own in vivo metabolism is long documented, the quantitative measurement of whole body glucose-mediated glucose disposal at basal insulin levels, [glucose effectiveness (GE)], followed the introduction of the Minimal Model IVGTT technique. METHODS: A literature review, combined with our own studies, of the role of GE in glucose metabolism in normal and "at risk" individuals, was undertaken to determine GE's contribution to glucose homeostasis...
February 16, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29451494/single-cell-transcriptional-dynamics-of-flavivirus-infection
#16
Fabio Zanini, Szu-Yuan Pu, Elena Bekerman, Shirit Einav, Stephen R Quake
Dengue and Zika viral infections affect millions of people annually and can be complicated by hemorrhage or neurological manifestations, respectively. However, a thorough understanding of the host response to these viruses is lacking, partly because conventional approaches ignore heterogeneity in virus abundance across cells. We present viscRNA-Seq (virus-inclusive single cell RNA-Seq), an approach to probe the host transcriptome together with intracellular viral RNA at the single cell level. We applied viscRNA-Seq to monitor dengue and Zika virus infection in cultured cells and discovered extreme heterogeneity in virus abundance...
February 16, 2018: ELife
https://www.readbyqxmd.com/read/29451386/optically-switchable-photocatalysis-in-ultrathin-black-phosphorus-nanosheets
#17
Hui Wang, Shenlong Jiang, Wei Shao, Xiaodong Zhang, Shichuan Chen, Xianshun Sun, Qun Zhang, Yi Luo, Yi Xie
Recently low-dimensional materials hold great potential in the field of photocatalysis, whereas the concomitantly promoted many-body effects have long been ignored. Such Coulomb interaction-mediated effects would lead to some intriguing, nontrivial band structures, thus promising versatile photocatalytic performances and optimized strategies. Here, we demonstrate that ultrathin black phosphorus (BP) nanosheets exhibit an exotic, excitation-energy-dependent, optical switching effect in photocatalytic reactive oxygen species (ROS) generation...
February 16, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29451089/randomization-based-inference-for-bernoulli-trial-experiments-and-implications-for-observational-studies
#18
Zach Branson, Marie-Abèle Bind
We present a randomization-based inferential framework for experiments characterized by a strongly ignorable assignment mechanism where units have independent probabilities of receiving treatment. Previous works on randomization tests often assume these probabilities are equal within blocks of units. We consider the general case where they differ across units and show how to perform randomization tests and obtain point estimates and confidence intervals. Furthermore, we develop rejection-sampling and importance-sampling approaches for conducting randomization-based inference conditional on any statistic of interest, such as the number of treated units or forms of covariate balance...
January 1, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29451062/exploratory-rearing-a-context-and-stress-sensitive-behavior-recorded-in-the-open-field-test
#19
Oliver Sturman, Pierre-Luc Germain, Johannes Bohacek
Stressful experiences are linked to anxiety disorders in humans. Similar effects are observed in rodent models, where anxiety is often measured in classic conflict tests such as the open-field test. Spontaneous rearing behavior, in which rodents stand on their hind legs to explore, can also be observed in this test yet is often ignored. We define two forms of rearing, supported rearing (in which the animal rears against the walls of the arena) and unsupported rearing (in which the animal rears without contacting the walls of the arena)...
February 16, 2018: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/29450613/extracolonic-findings-and-radiation-at-ct-colonography-what-the-referring-provider-needs-to-know
#20
Judy Yee, Elizabeth McFarland
A better understanding of the risks and benefits of extracolonic findings and radiation dose will aid in the safe and proper implementation of CT colonography in clinical practice. The majority of extracolonic findings in screening patients are benign and can be ignored by referring physicians. Radiologists also need to be responsible in reporting extracolonic findings. Referring providers must be knowledgeable about the theoretic risks and controversies regarding the use of ionizing radiation. Screening CT colonography imparts a low-level of radiation to patients that is equivalent or less than annual background dose...
February 15, 2018: Abdominal Radiology
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