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https://www.readbyqxmd.com/read/28212920/neonatal-lupus-follow-up-in-infants-with-anti-ssa-ro-antibodies-and-review-of-the-literature
#1
REVIEW
Antonio Alberto Zuppa, Riccardo Riccardi, Simonetta Frezza, Francesca Gallini, Rita Maria Paola Luciano, Giovanni Alighieri, Costantino Romagnoli, Sara De Carolis
Neonatal Lupus Syndrome (NLS) is a distinct clinical entity caused by transplacental passage of maternal anti-SSA/Ro antibodies (Ab). Mothers may have systemic lupus erythematosus, Sjögren syndrome, or other connective tissue disease, or may be completely healthy at the time of giving birth. NLS includes several clinical manifestations: complete congenital heart block (CCHB) and cutaneous lupus are the most common, while hepatobiliary disease, hematological manifestations and central nervous system involvement may occur...
February 14, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28210491/film-morphology-evolution-during-solvent-vapor-annealing-of-highly-efficient-small-molecule-donor-acceptor-blends
#2
Sebastian Engmann, Hyun Wook Ro, Andrew Herzing, Chad R Snyder, Lee J Richter, Paul B Geraghty, David J Jones
Solution-processable small molecule photovoltaics based on the novel molecular donor, benzodithiophene terthiophene rhodanine (BTR), recently have shown maximum power conversion efficiencies above 8 % for active layer thicknesses up to 400 nm, using post process solvent vapor annealing (SVA) with tetrahydrofuran (THF). Here we report an in-situ study on the morphology evolution during SVA using the moderate solvent THF and the good solvent chloroform (CF). The combination of real-time grazing incidence X-ray diffraction (GIXD) and grazing incidence small angle X-ray scattering (GISAXS) allows us to draw a complete picture of the evolution of crystallinity and phase purity during post process annealing...
October 28, 2016: Journal of Materials Chemistry. A, Materials for Energy and Sustainability
https://www.readbyqxmd.com/read/28204917/-ecg-score-to-predict-icd-therapies-in-patients-with-nonischemic-cardiomyopathy-and-primary-prophylactic-crt-d
#3
Martin Grett, Martin Christ, Jan-Peter Röing Gen Nölke, Hans-Joachim Trappe
BACKGROUND AND PROBLEM: Recently published results of the DANISH study raise concerns, if primary prophylactic ICD implantations in patients with nonischemic cardiomyopathy (NICM) and severe reduced left ventricular ejection fraction (LVEF) should be performed without further risk stratification. There was no significant difference in the overall mortality of patients with or without ICD and CRT defibrillator (CRT-D) or CRT pacemaker (CRT-P), respectively. Clinical risk scores to identify patients with ischemic cardiomyopathy (ICM) who benefit most from an ICD have been recommended...
February 15, 2017: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/28204891/low-titer-isolated-anti-ro-ssa-60-kd-antibodies-is-correlated-with-positive-pregnancy-outcomes-in-women-at-risk-of-congenital-heart-block
#4
Marta Tonello, Ariela Hoxha, Elena Mattia, Alessandra Zambon, Silvia Visentin, Alessia Cerutti, Anna Ghirardello, Ornella Milanesi, Amelia Ruffatti
Congenital heart block (CHB) is an autoantibody mediated disorder presumably caused by placental transmission of maternal autoantibodies to Ro/SSA 52 kd, p200, Ro/SSA 60 kd, La/SSB ribonucleoproteins. This study investigated the clinical significance of isolated anti-Ro/SSA 52 kd, anti-p200, anti-Ro/SSA 60 kd, and anti-La/SSB antibodies in positive pregnant patients. One hundred sixty-three pregnant women positive to anti-Ro/SSA 52 kd and/or anti-Ro/SSA 60 kd and/or anti-La/SSB antibodies were prospectively enrolled in the study...
February 15, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28198918/artificial-diet-for-laboratory-rearing-of-condylorrhiza-vestigialis-guen%C3%A3-e-1854-lep-crambidae
#5
Lucas S Campos, Aloisio Coelho, José Roberto P Parra
The Brazilian Poplar Moth, Condylorrhiza vestigialis (Guenée), compromises the wood productivity of poplar trees (Populus sp.), mainly affecting the matchstick industry in southern Brazil. Considering the lack of information on rearing techniques for this insect, the objective of this study was to develop an artificial diet to rear C. vestigialis with biological characteristics similar to the wild insects. A properly diet will enable bio-ecological studies and biological control programs using the baculovirus Condylorrhiza vestigialis multiple nucleopolyhedrovirus (CvMNPV)...
February 9, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28196952/revalidation-and-quality-assurance-the-application-of-the-musiq-framework-in-independent-verification-visits-to-healthcare-organisations
#6
Ann Griffin, Alex McKeown, Rowena Viney, Antonia Rich, Trevor Welland, Irene Gafson, Katherine Woolf
OBJECTIVES: We present a national evaluation of the impact of independent verification visits (IVVs) performed by National Health Service (NHS) England as part of quality assuring medical revalidation. Organisational visits are central to NHS quality assurance. They are costly, yet little empirical research evidence exists concerning their impact, and what does exist is conflicting. SETTING: The focus was on healthcare providers in the NHS (in secondary care) and private sector across England, who were designated bodies (DBs)...
February 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/28196050/visualization-of-the-macula-in-gas-filled-eyes-spectral-domain-optical-coherence-tomography-versus-swept-source-optical-coherence-tomography
#7
Seong Joon Ahn, Seung Hoon Park, Byung Ro Lee
PURPOSE: To compare the visualization of the macula between spectral domain optical coherence tomography (SD-OCT) and swept-source OCT (SS-OCT) in gas-filled eyes. METHODS: Sixty-one patients with common indications of gas tamponade, including 27 with macular holes and 34 with rhegmatogenous retinal detachment, who were treated with vitrectomy and gas tamponade were imaged using both SD-OCT (3D-OCT 2000, Topcon, Tokyo, Japan) and SS-OCT (DRI-OCT, Topcon) at 1, 3, and 7 days after the surgery...
February 10, 2017: Retina
https://www.readbyqxmd.com/read/28194440/transient-antibody-targeting-of-cd45rc-induces-transplant-tolerance-and-potent-antigen-specific-regulatory-t-cells
#8
Elodie Picarda, Séverine Bézie, Laetitia Boucault, Elodie Autrusseau, Stéphanie Kilens, Dimitri Meistermann, Bernard Martinet, Véronique Daguin, Audrey Donnart, Eric Charpentier, Laurent David, Ignacio Anegon, Carole Guillonneau
Rat and human CD4(+) and CD8(+) Tregs expressing low levels of CD45RC have strong immunoregulatory properties. We describe here that human CD45 isoforms are nonredundant and identify distinct subsets of cells. We show that CD45RC is not expressed by CD4(+) and CD8(+) Foxp3(+) Tregs, while CD45RA/RB/RO are. Transient administration of a monoclonal antibody (mAb) targeting CD45RC in a rat cardiac allotransplantation model induced transplant tolerance associated with inhibition of allogeneic humoral responses but maintained primary and memory responses against cognate antigens...
February 9, 2017: JCI Insight
https://www.readbyqxmd.com/read/28193653/the-pa-endonuclease-inhibitor-ro-7-protects-mice-from-lethal-challenge-with-influenza-a-or-b-viruses
#9
Jeremy C Jones, Bindumadhav M Marathe, Peter Vogel, Rodolfo Gasser, Isabel Najera, Elena A Govorkova
Current influenza treatment relies on a single class of antiviral drugs, the neuraminidase inhibitors (NAIs), raising concern over the potential emergence of resistant variants and necessitating the development of novel drugs. In recent years, investigational inhibitors targeting the endonuclease activity of the influenza acidic polymerase (PA) protein have yielded encouraging results, although there are only limited data on their in vivo efficacy. Here, we examined the antiviral potential of the PA endonuclease inhibitor RO-7 in prophylactic and therapeutic regimens in BALB/c mice inoculated with influenza A/California/04/2009 (H1N1)pdm09 or B/Brisbane/60/2008 viruses, which represent currently circulating antigenic variants...
February 13, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28193134/non-coronary-vascular-calcification-bone-mineral-density-and-muscle-mass-in-institutionalized-frail-nonagenarians
#10
Fernando Idoate, Eduardo L Cadore, Alvaro Casas-Herrero, Fabricio Zambom-Ferraresi, Nicolas Martinez-Velilla, Leocadio Rodriguez-Mañas, Pedro M Azkarate, Martim Bottaro, Robison Ramírez-Vélez, Mikel Izquierdo
The purpose of this study was to compare the vascular calcification at thoracic (TAC) and ab-dominal (AAC) aorta, iliac (IAC) and femoral (FAC) arteries, and bone mineral density (BMD) of the lumbar vertebrae between frail and robust nonagenarians, as well as to verify the associations between vascular calcification with BMD, muscle tissue quality and quantity in both groups. Forty-two elderly subjects participated in this study: 29 institutionalized frail (92.0±3.2 years) and 13 ro-bust (89.0±4.0 years) elderly participants...
February 14, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28192364/membrane-technology-applied-to-acid-mine-drainage-from-copper-mining
#11
K Ambiado, C Bustos, A Schwarz, R Bórquez
The objective of this study is to evaluate the treatment of high-strength acid mine drainage (AMD) from copper mining by nanofiltration (NF) and reverse osmosis (RO) at pilot scale. The performances of two commercial spiral-wound membranes - NF99 and RO98pHt, both from Alfa Laval - were compared. The effects of pressure and feed flow on ion rejection and permeate flux were evaluated. The results showed high ion removal under optimum pressure conditions, which reached 92% for the NF99 membrane and 98% for the RO98pHt membrane...
February 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28191654/epidemiology-and-cardiovascular-comorbidities-in-patients-with-psoriasis-a-korean-nationwide-population-based-cohort-study
#12
Eui Hyun Oh, Young Suck Ro, Jeong Eun Kim
There is a lack of nationwide studies examining the epidemiology and comorbidities of psoriasis vulgaris (PsV) and psoriatic arthritis (PsA) in Asian populations. The purpose of this study is to determine the demographics of psoriasis in Korea along with the incidence of cerebro-cardiovascular (CV) comorbidities and to compare these risks between populations with PsA and with PsV. This cohort study identified 15 484 patients with psoriasis among 855 003 subjects in the Korean National Health Insurance Database from 2002 through 2010...
February 13, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28191013/quercetin-and-quercetin-rich-red-onion-extract-alter-pgc-1%C3%AE-promoter-methylation-and-splice-variant-expression
#13
Prasad P Devarshi, Aarin D Jones, Erin M Taylor, Barbara Stefanska, Tara M Henagan
Pgc-1α and its various isoforms may play a role in determining skeletal muscle mitochondrial adaptations in response to diet. 8 wks of dietary supplementation with the flavonoid quercetin (Q) or red onion extract (ROE) in a high fat diet (HFD) ameliorates HFD-induced obesity and insulin resistance in C57BL/J mice while upregulating Pgc-1α and increasing skeletal muscle mitochondrial number and function. Here, mice were fed a low fat (LF), high fat (HF), high fat plus quercetin (HF + Q), or high fat plus red onion extract (HF + RO) diet for 9 wks and skeletal muscle Pgc-1α isoform expression and DNA methylation were determined...
2017: PPAR Research
https://www.readbyqxmd.com/read/28190755/quantitative-prediction-of-histamine-h1-receptor-occupancy-by-the-sedative-and-non-sedative-antagonists-in-the-human-central-nervous-system-based-on-systemic-exposure-and-preclinical-data
#14
Kayoko Kanamitsu, Yoshitane Nozaki, Yoko Nagaya, Yuichi Sugiyama, Hiroyuki Kusuhara
Significant histamine H1 receptor occupation in the central nervous system (CNS) is associated with sedation. Here we examined the time profiles of the H1 receptor occupancy (RO) in the CNS using sedative (diphenhydramine and ketotifen) and non-sedative (bepotastine and olopatadine) antagonists at their therapeutic doses by integrating in vitro and animal data. A pharmacokinetic model was constructed to associate plasma concentrations and receptor binding in the brain. Dissociation and association rate constants with the H1 receptor and plasma and brain unbound fractions were determined in vitro...
November 18, 2016: Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/28188860/genetic-incorporation-of-n-%C3%AE%C2%B5-acetyllysine-reveals-a-novel-acetylation-sumoylation-switch-in-yeast
#15
Sang-Woo Kim, Kyung Jin Lee, Sinil Kim, Jihyo Kim, Kyukwang Cho, Hyeon-Su Ro, Hee-Sung Park
The lysine acetylation of proteins plays a key role in regulating protein functions, thereby controlling a wide range of cellular processes. Despite the prevalence and significance of lysine acetylation in eukaryotes, however, its systematic study has been challenged by the technical limitations of conventional approaches for selective lysine acetylation in vivo. Here, we report the in vivo study of lysine acetylation via the genetic incorporation of N(ε)-acetyllysine in yeast. We demonstrate that a newly discovered acetylation-sumoylation switch precisely controls the localization and cellular function of the yeast septin protein, Cdc11, during the cell cycle...
February 7, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28188782/lipid-and-carotenoid-cooperation-driven-adaptation-to-light-and-temperature-stress-in-synechocystis-sp-pcc6803
#16
Tomas Zakar, Eva Herman, Sindhujaa Vajravel, Laszlo Kovacs, Jana Knoppová, Josef Komenda, Ildiko Domonkos, Mihaly Kis, Zoltan Gombos, Hajnalka Laczko-Dobos
Polyunsaturated lipids are important components of photosynthetic membranes. Xanthophylls are the main photoprotective agents, can assist in protection against light stress, and are crucial in the recovery from photoinhibition. We generated the xanthophyll- and polyunsaturated lipid-deficient ROAD mutant of Synechocystis sp. PCC6803 (Synechocystis) in order to study the little-known cooperative effects of lipids and carotenoids (Cars). Electron microscopic investigations confirmed that in the absence of xanthophylls the S-layer of the cellular envelope is missing...
February 7, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28185656/subacute-cutaneous-lupus-erythematosus-clinical-characteristics-disease-associations-treatments-and-outcomes-in-a-series-of-90%C3%A2-patients-at-mayo-clinic-1996-2011
#17
Dema T Alniemi, Albert Gutierrez, Lisa A Drage, David A Wetter
OBJECTIVE: To characterize the clinical presentation, laboratory studies, disease associations, and treatments of subacute cutaneous lupus erythematosus (SCLE). PATIENTS AND METHODS: A retrospective review of 90 patients with SCLE at Mayo Clinic from January 1, 1996, through October 28, 2011, was performed. RESULTS: The mean patient age at diagnosis was 61 years; 64 patients (71%) were women, and 11 cases (12%) were drug induced (1996-2000, no drug-induced cases; 2001-2005, 2 cases; 2006-2011, 9 cases)...
February 6, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28184097/the-abundance-of-c2h4-in-the-circumstellar-envelope-of-irc-10216
#18
J P Fonfría, K H Hinkle, J Cernicharo, M J Richter, M Agúndez, L Wallace
High spectral resolution mid-IR observations of ethylene (C2H4) towards the AGB star IRC+10216 were obtained using the Texas Echelon Cross Echelle Spectrograph (TEXES) at the NASA Infrared Telescope Facility (IRTF). Eighty ro-vibrational lines from the 10.5 µm vibrational mode ν7 with J ≲ 30 were detected in absorption. The observed lines are divided into two groups with rotational temperatures of 105 and 400 K (warm and hot lines). The warm lines peak at ≃ -14 km s(-1) with respect to the systemic velocity, suggesting that they are mostly formed outwards from ≃ 20R⋆...
February 1, 2017: Astrophysical Journal
https://www.readbyqxmd.com/read/28183034/effects-of-chemical-cleaning-on-ro-membrane-inorganic-organic-and-microbial-foulant-removal-in-a-full-scale-plant-for-municipal-wastewater-reclamation
#19
Tong Yu, Lu Meng, Qing-Bo Zhao, Ye Shi, Hong-Ying Hu, Yun Lu
Of all of the strategies for controlling reverse osmosis (RO) membrane fouling, chemical cleaning is indispensable. To study the effects of chemical cleaning on membrane foulant removal, a comparative analysis of RO membranes before and after common alkaline and acid cleaning was conducted by dissecting lead and terminal RO membranes in a full-scale municipal wastewater reclamation plant. Most foulants on the membranes were removed by chemical cleaning processes. Calcium was the major inorganic component of the foulants because of its highest concentration in the feed water...
February 2, 2017: Water Research
https://www.readbyqxmd.com/read/28181950/clinicopathologic-and-molecular-pathology-of-collecting-duct-carcinoma-and-related-renal-cell-carcinomas
#20
An Na Seo, Ghilsuk Yoon, Jae Y Ro
Collecting duct carcinoma (CDC) and related tumors [ie, renal medullary carcinoma (RMC)] are rare types of highly aggressive renal cell carcinomas (RCC) with poor prognosis. Because of the rarity and diagnostic uncertainty of them, their molecular pathology and significance have not yet been fully elucidated. CDC, RMC, fumarate hydratase-deficient RCC (including hereditary leiomyomatosis and RCC-associated RCC HLRCC-RCC), and recently reported anaplastic lymphoma kinase (ALK)-rearrangement RCC have significant morphologic overlaps, but they are separately distinct entities having different molecular pathway and clinical settings...
March 2017: Advances in Anatomic Pathology
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