keyword
MENU ▼
Read by QxMD icon Read
search

Validity testing

keyword
https://www.readbyqxmd.com/read/28434127/intranasal-vitamin-a-is-beneficial-in-post-infectious-olfactory-loss
#1
Thomas Hummel, Katherine L Whitcroft, Gina Rueter, Antje Haehner
Vitamin A plays a decisive role in the regeneration of olfactory receptor neurons. In this retrospective study we investigated the effectiveness of topical vitamin A in patients with post-infectious and posttraumatic smell disorders. Retrospective cohort. A total of 170 patients (age range 18-70 years, mean age 52 years) participated. Forty-six patients were treated with smell training only. The remaining 124 patients received smell training and topical vitamin A. Olfactory function was assessed using the Sniffin' Sticks test kit, a validated technique to measure odor thresholds, discrimination and identification...
April 22, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28434075/associations-of-self-reported-smoking-cotinine-levels-and-epigenetic-smoking-indicators-with-oxidative-stress-among-older-adults-a-population-based-study
#2
Xu Gao, Xīn Gào, Yan Zhang, Lutz Philipp Breitling, Ben Schöttker, Hermann Brenner
Tobacco smoking and oxidative stress (OS) are both related to a wide spectrum of adverse age-related health outcomes, but their association is not yet well-established. We examined the associations of self-reported smoking indicators, serum cotinine levels and smoking-related DNA methylation biomarkers with two urinary proxy markers of OS, 8-isoprostane (8-iso) and 8-hydroxy-2'-deoxyguanosine (8-oxodG), in two independent subsets of older adults recruited in Germany (discovery set: n = 978, validation set: n = 531)...
April 22, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28433867/validity-and-repeatability-of-inertial-measurement-units-for-measuring-gait-parameters
#3
Edward P Washabaugh, Tarun Kalyanaraman, Peter G Adamczyk, Edward S Claflin, Chandramouli Krishnan
Inertial measurement units (IMUs) are small wearable sensors that have tremendous potential to be applied to clinical gait analysis. They allow objective evaluation of gait and movement disorders outside the clinic and research laboratory, and permit evaluation on large numbers of steps. However, repeatability and validity data of these systems are sparse for gait metrics. The purpose of this study was to determine the validity and between-day repeatability of spatiotemporal metrics (gait speed, stance percent, swing percent, gait cycle time, stride length, cadence, and step duration) as measured with the APDM Opal IMUs and Mobility Lab system...
April 12, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28433831/ultrasonography-of-the-transverse-movement-and-deformation-of-the-median-nerve-and-its-relationships-with-electrophysiological-severity-in-the-early-stages-of-carpal-tunnel-syndrome
#4
Donghwi Park
BACKGROUND: To date, there have been conflicting suggestions regarding theinitial pathogenesis of CTS.It has been characterized as either inflammation of the median nerve caused by compression ornon-inflammatory fibrosis of the subsynovial connective tissue (SSCT). OBJECTIVE: To investigate the initialpathogenesis of CTS, we compared the deformation and displacement of the median nerve in accordance with the electrophysiological severity between patients with CTS (via Bland`s scale) and healthy controls...
April 19, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28433792/a-pilot-study-examining-a-computer-based-intervention-to-improve-recognition-and-understanding-of-emotions-in-young-children-with-communication-and-social-deficits
#5
Neri L Romero
BACKGROUND: A common social impairment in individuals with ASD is difficulty interpreting and or predicting emotions of others. To date, several interventions targeting teaching emotion recognition and understanding have been utilized both by researchers and practitioners. The results suggest that teaching emotion recognition is possible, but that the results do not generalize to non-instructional contexts. This study sought to replicate earlier findings of a positive impact of teaching emotion recognition using a computer-based intervention and to extend it by testing for generalization on live models in the classroom setting...
April 20, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28433524/an-analysis-of-knowledge-based-planning-for-stereotactic-body-radiation-therapy-of-the-spine
#6
Joseph J Foy, Robin Marsh, Randall K Ten Haken, Kelly C Younge, Matthew Schipper, Yilun Sun, Dawn Owen, Martha M Matuszak
PURPOSE: Planning for spine stereotactic body radiation therapy (SBRT) is time consuming, and differences in planner experience and technique result in discrepancies in plan quality between facilities. Here, knowledge-based planning is analyzed to determine if it may be effective in improving the quality and efficiency of spine SBRT planning. MATERIALS AND METHODS: Thirty-eight spine SBRT cases were collected from the University of Michigan database and inverse planned to deliver 3 10-Gy fractions to the planning target volume (PTV)...
March 2, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28433390/a-computational-study-of-invariant-i5-in-a-nearly-incompressible-transversely-isotropic-model-for-white-matter
#7
Yuan Feng, Suhao Qiu, Xiaolong Xia, Songbai Ji, Chung-Hao Lee
The aligned axonal fiber bundles in white matter make it suitable to be modeled as a transversely isotropic material. Recent experimental studies have shown that a minimal form, nearly incompressible transversely isotropic (MITI) material model, is capable of describing mechanical anisotropy of white matter. Here, we used a finite element (FE) computational approach to demonstrate the significance of the fifth invariant (I5) when modeling the anisotropic behavior of white matter in the large-strain regime. We first implemented and validated the MITI model in an FE simulation framework for large deformations...
April 9, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28433078/haplotype-counting-for-sensitive-chimerism-testing-potential-for-early-leukemia-relapse-detection
#8
Marija Debeljak, Evelina Mocci, Max C Morrison, Aparna Pallavajjalla, Katie Beierl, Marie Amiel, Michaël Noë, Laura D Wood, Ming-Tseh Lin, Christopher D Gocke, Alison P Klein, Ephraim J Fuchs, Richard J Jones, James R Eshleman
Fields of forensics, transplantation, and paternity rely on human identity testing. Currently, this is accomplished through amplification of microsatellites followed by capillary electrophoresis. An alternative and theoretically better approach uses multiple single-nucleotide polymorphisms located within a small region of DNA, a method we initially developed using HLA-A and called haplotype counting. Herein, we validated seven additional polymorphic loci, sequenced a total of 45 individuals from three of the 1000 Genomes populations (15 from each), and determined the number of haplotypes, heterozygosity, and polymorphic information content for each locus...
May 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/28433077/development-and-clinical-utility-of-a-blood-based-test-service-for-the-rapid-identification-of-actionable-mutations-in-non-small-cell-lung-carcinoma
#9
Hestia Mellert, Trudi Foreman, Leisa Jackson, Dianna Maar, Scott Thurston, Kristina Koch, Amanda Weaver, Samantha Cooper, Nicholas Dupuis, Ubaradka G Sathyanarayana, Jakkie Greer, Westen Hahn, Dawne Shelton, Paula Stonemetz, Gary A Pestano
Nearly 80% of cancer patients do not have genetic mutation results available at initial oncology consultation; up to 25% of patients begin treatment before receiving their results. These factors hinder the ability to pursue optimal treatment strategies. This study validates a blood-based genome-testing service that provides accurate results within 72 hours. We focused on targetable variants in advanced non-small cell lung carcinoma-epidermal growth factor receptor gene (EGFR) variant L858R, exon 19 deletion (ΔE746-A750), and T790M; GTPase Kirsten ras gene (KRAS) variants G12C/D/V; and echinoderm microtubule associated protein like and 4 anaplastic lymphoma receptor tyrosine kinase fusion (EML4-ALK) transcripts 1/2/3...
May 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/28432983/improved-resolution-and-simplification-of-the-spin-diffusion-based-nmr-method-for-the-structural-analysis-of-mixed-linker-mofs
#10
Andraž Krajnc, Bart Bueken, Dirk De Vos, Gregor Mali
Nuclear magnetic resonance spectroscopy combined with modeling represents a powerful tool for the structural analysis of heterogeneous materials. In this contribution we describe an upgraded method, particularly suited for the structural analysis of mixed-linker metal-organic framework materials, which is based on the measurement and modeling of proton spin diffusion among constituents. We tested the method on a UiO-66-type metal-organic material, in which the organic building units were 1,4-benzenedicarboxylate and trans-1,4-cyclohexanedicarboxylate anions distributed within the framework in an unknown manner...
April 12, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28432935/accelerometry-based-assessment-and-detection-of-early-signs-of-balance-deficits
#11
Heidi Similä, Milla Immonen, Miikka Ermes
Falls are the cause for more than half of the injury-related hospitalizations among older people. Accurate assessment of individuals' fall risk could enable targeted interventions to reduce the risk. This paper presents a novel method for using wearable accelerometers to detect early signs of deficits in balance from gait. Gait acceleration data were analyzed from 35 healthy female participants (73.86±5.40 years). The data were collected with waist-mounted accelerometer and the participants performed three supervised balance tests: Berg Balance Scale (BBS), Timed-Up-and-Go (TUG) and 4m walk...
April 13, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28432841/comparison-of-pneumatic-tube-system-with-manual-transport-for-routine-chemistry-hematology-coagulation-and-blood-gas-tests
#12
Alex Pupek, Beverly Matthewson, Erin Whitman, Rachel Fullarton, Yu Chen
BACKGROUND: The pneumatic tube system (PTS) is commonly used in modern clinical laboratories to provide quick specimen delivery. However, its impact on sample integrity and laboratory testing results are still debatable. In addition, each PTS installation and configuration is unique to its institution. We sought to validate our Swisslog PTS by comparing routine chemistry, hematology, coagulation and blood gas test results and sample integrity indices between duplicate samples transported either manually or by PTS...
April 22, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28432780/single-subject-independent-component-analysis-based-intensity-normalization-in-non-quantitative-multi-modal-structural-mri
#13
Sebastian Papazoglou, Jens Würfel, Friedemann Paul, Alexander U Brandt, Michael Scheel
Non-quantitative MRI is prone to intersubject intensity variation rendering signal intensity level based analyses limited. Here, we propose a method that fuses non-quantitative routine T1-weighted (T1w), T2w, and T2w fluid-saturated inversion recovery sequences using independent component analysis and validate it on age and sex matched healthy controls. The proposed method leads to consistent and independent components with a significantly reduced coefficient-of-variation across subjects, suggesting potential to serve as automatic intensity normalization and thus to enhance the power of intensity based statistical analyses...
April 22, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28432659/current-role-of-blood-and-urine-biomarkers-in-the-clinical-care-of-adults-with-congenital-heart-disease
#14
REVIEW
Saurabh Rajpal, Laith Alshawabkeh, Alexander R Opotowsky
PURPOSE OF REVIEW: There is an increasing number of adult patients with congenital heart disease (CHD). While several biomarkers have been validated and integrated into general cardiology clinical practice, these tests are often applied to adults with CHD in the absence of disease-specific validation. Although these patients are often grouped into a single population, there is heterogeneous pathophysiology, variable disease chronicity, extensive multisystem involvement, and a low event rate relative to acquired heart disease...
June 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28432624/delivering-environmental-benefit-from-the-use-of-environmental-quality-standards-why-we-need-to-focus-on-implementation
#15
Graham Merrington, Adam Peters, Paul Whitehouse, Robin Clarke, Dan Merckel
The UK has adopted a broader approach to the introduction of Environmental Quality Standard (EQS) for the aquatic environment than many other jurisdictions around the world, with a greater focus on the implementation of scientifically derived standards. This follows the publication of a report by the Royal Commission on Environmental Pollution in 1998 which drew attention to the need to recognise that whilst an EQS is often just viewed as a numerical value, it also has other important characteristics that need to be recognised if it is to be a practical and effective regulatory tool...
April 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28432586/cdc20-with-malignant-progression-and-poor-prognosis-of-astrocytoma-revealed-by-analysis-on-gene-expression
#16
Yiming Ding, Shuqing Yu, Zhaoshi Bao, Yanwei Liu, Tingyu Liang
The malignant transformation of astrocytoma may result from the accumulation of multiple genetic alterations. Current research shows that diffuse astrocytoma (AIIs, WHO grade II) is inherently predisposed to recur locally, and to spontaneously progress to anaplastic astrocytoma (AAIIIs, WHO grade III) and eventually secondary glioblastoma (sGBMIVs, WHO grade IV). The aim of the study was to identify and validate the important gene(s) associated with malignant progression and poor prognosis of astrocytoma. Average expression levels of 82 samples (35 AIIs, 13 AAIIIs and 34 sGBMIVs) were compared to each other through no-paired student test...
April 21, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28432524/correlation-of-serum-mmp3-and-other-biomarkers-with-clinical-outcomes-in-patients-with-ankylosing-spondylitis-a-pilot-study
#17
Dongyi He, Qi Zhu, Quan Zhou, Qing Qi, Hongmei Sun, Liza M Zachariah, Grace Wang, John D Reveille, Yongtao Guan, Xiaodong Zhou
The studies aimed to assess a set of biomarkers for their correlations with disease activity/severity of patients with ankylosing spondylitis (AS). A total of 24 AS patients were treated with etanercept and prospectively followed for 12 weeks. Serum levels of TNF-α, IFN-γ, TGF-β, IL6, IL15, IL17, MMP3, and MICA were measured at baseline and after treatment. The change of these biomarkers was analyzed for correlations with MRI indices for joint inflammation, Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Functional Index, AS Disease Activity Score, serum CRP, and ESR...
April 22, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28432150/specialist-generalist-model-of-body-temperature-regulation-can-be-applied-on-the-intraspecific-level
#18
Anna S Przybylska, Jan S Boratyński, Michał S Wojciechowski, Małgorzata Jefimow
According to theoretical predictions endothermic homeotherms can be classified as either thermal specialists and thermal generalists. In high cost environments thermal specialists are supposed to be more prone to use facultative heterothermy than generalists. We tested this hypothesis on the intraspecific level using laboratory male mice (C57BL/cmdb) fasted under different thermal conditions (20 and 10°C), and for different time periods (12-48 h). We predicted that variability of body temperature (Tb) and time spent with Tb below normothermy increase with the increase of environmental demands (duration of fasting and cold)...
April 21, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28432057/imaging-and-modeling-of-acute-pressure-induced-changes-of-collagen-and-elastin-microarchitectures-in-pig-and-human-resistance-arteries
#19
Maria Bloksgaard, Thomas M Leurgans, Bart Spronck, Maarten Hg Heusinkveld, Bjarne Thorsted, Kristoffer Rosenstand, Inger Nissen, Ulla Melchior Hansen, Jonathan R Brewer, Luis A Bagatolli, Lars M Rasmussen, Akhmadjon Irmukhamedov, Koen D Reesink, Jo G R De Mey
The impact of disease related changes in the extracellular matrix (ECM) on the mechanical properties of human resistance arteries largely remains to be established. Resistance arteries from both pig and human parietal pericardium (PRA) display a different ECM microarchitecture compared to frequently used rodent mesenteric arteries. We hypothesized that the biaxial mechanics of PRA mirror pressure induced changes in the ECM microarchitecture. This was tested using isolated pig PRA as model system, integrating vital imaging, pressure myography and mathematical modeling...
April 21, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28432049/randomized-controlled-trial-of-different-aspirin-regimens-for-reduction-of-niacin-induced-flushing
#20
Sahil S Banka, Rosy Thachil, Alexander Levine, Hsin Lin, Haytham Kaafarani, Jarone Lee
PURPOSE: Results of a study to test the hypothesis that taking niacin simultaneously with different forms of aspirin would reduce the occurrence of niacin-induced flushing are reported. METHODS: Traditionally, taking enteral absorbed aspirin 30 minutes before a niacin dose has been shown to reduce flushing by 30-50% relative to nonuse of aspirin. The objective of the study was to evaluate the efficacy of enteral absorbed and orally dissolved aspirin, taken at the same time as niacin, in reducing the frequency of moderate-to-severe flushing...
April 21, 2017: American Journal of Health-system Pharmacy: AJHP
keyword
keyword
76610
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"